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Gene Dmel\sti

General Information
Symbol	Dmel\sti	Species	D. melanogaster
Name	sticky	Annotation symbol	CG10522
Feature type	protein_coding_gene	FlyBase ID	FBgn0002466
Gene Model Status	Current	Stock availability	9 publicly available
Also Known As	dck, cit, l(3)7m62, l(3)7m-62
Genomic Location
Chromosome (arm)	3L	Recombination map	3-36.8
Cytogenetic map	69C4-69C4	Sequence location	3L:12,501,090..12,507,889 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene sticky is referred to in FlyBase by the symbol Dmel\sti (CG10522, FBgn0002466). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: diacylglycerol binding; protein serine/threonine kinase activity. There is experimental evidence that it is involved in the biological process: cytokinesis after mitosis; chromatin organization; cytokinesis; cytokinesis, completion of separation; cytokinesis, actomyosin contractile ring assembly; regulation of actin cytoskeleton organization. 23 alleles are reported. The phenotypes of these alleles are annotated with: organ system; organ system subdivision; external compound sense organ; organelle; somatic cell; compound cell cluster organ; nervous system; protein complex; presumptive embryonic/larval nervous system; spermatocyte; imaginal precursor; female germline cyst; nucleus. It has one annotated transcript and one annotated polypeptide. Protein features are: AGC-kinase, C-terminal; Citron-like; Protein kinase C-like, phorbol ester/diacylglycerol binding; Protein kinase, ATP binding site; Protein kinase, C-terminal; Protein kinase, catalytic domain; Protein kinase-like domain; Serine/threonine-protein kinase, active site; Serine/threonine-protein kinase, catalytic domain; Serine/threonine-protein kinase-like domain. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of very low expression. Peak expression observed within 00-06 hour embryonic stages. Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: larval central nervous system, adult ovary. Comments on Affy2 ProbeSet: ProbeSet 1637424_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of sti. Gene sequence location is 3L:12501090..12507889.
External Summaries
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2011_10	References Yin et al., 2008, BMC Bioinformatics 9: 264
FB2012_01	Alleles sti[CMV111] sti[D97] sti[IV61] References Bassi et al., 2011, J. Cell Biol. 195(4): 595--603 Sequence features BKN50916 BKN22215 BKN50944 HFA09740 HFA09739
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 69C4-69C4   Limits computationally determined from genome sequence between P{PZ}l(3)0508805088 and P{PZ}l(3)0692406924
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location	3-36.8 (Gatti and Baker, 1989, ) 3-36 (Sweeney et al., 2008)
Left of (cM)	th (Sweeney et al., 2008)
Right of (cM)	h (Sweeney et al., 2008)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\sti for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) sti-RA FBtr0075970  NM_140327   6054   1854
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein sti-PA   FBpp0075702   211.3   1854   6.71     NP_648584   AAF49907
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Protein kinase, catalytic domain (IPR000719) AGC-kinase, C-terminal (IPR000961) Citron-like (IPR001180) Protein kinase C-like, phorbol ester/diacylglycerol binding (IPR002219) Serine/threonine-protein kinase, catalytic domain (IPR002290) Serine/threonine-protein kinase, active site (IPR008271) Protein kinase-like domain (IPR011009) Protein kinase, ATP binding site (IPR017441) Serine/threonine-protein kinase-like domain (IPR017442) Protein kinase, C-terminal (IPR017892)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA201284   AA202099   AA264853   AA391654   AA539198   AA952295   AA979045   AE014296 AAF49907   AI260476   AI534232   AX094264   BH740764   BI228701   BI230217   BI613673   BI620601   BT010266 AAQ23584   BT081968   CO266221   CO284965   CO295879   CO316663   CO326170   CO330176   CO331804   CO341190   CO342145   CO342376   EC053060   EC054029   EC061527   EC062623   EC078933   EC212821   EC224724   EC239689   EC252237   EC253061   EC258251   EV592684   FE862901   GH861174
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q6NR17 Q9VTY8
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0002466    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0002466 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of very low expression. Peak expression observed within 00-06 hour embryonic stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0002466 expression level Developmental Stage   Expression Level embryo 00-02hr    4029 embryo 02-04hr    7637 embryo 04-06hr    10553 embryo 06-08hr    9537 embryo 08-10hr    6598 embryo 10-12hr    2948 embryo 12-14hr    2238 embryo 14-16hr    1611 embryo 16-18hr    1219 embryo 18-20hr    595 embryo 20-22hr    2302 embryo 22-24hr    1876 larva L1    72 larva L2    122 larva L3 12hr old    226 larva L3 puffstage 1-2    587 larva L3 puffstage 3-6    944 larva L3 puffstage 7-9    988 white prepupae new    874 white prepupae 12hr    1598 white prepupae 24hr    1247 pupae 2d postWPP    257 pupae 3d postWPP    127 pupae 4d postWPP    169 adult male 01day    135 adult male 05day    229 adult male 30day    199 adult female 01day    596 adult female 05day    1437 adult female 30day    1617 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (4029) embryo 02-04hr  (7637) embryo 04-06hr  (10553) embryo 06-08hr  (9537) embryo 08-10hr  (6598) embryo 10-12hr  (2948) embryo 12-14hr  (2238) embryo 14-16hr  (1611) embryo 16-18hr  (1219) embryo 18-20hr  (595) embryo 20-22hr  (2302) embryo 22-24hr  (1876) larva L1    72 larva L2  (122) larva L3 12hr old  (226) larva L3 puffstage 1-2  (587) larva L3 puffstage 3-6  (944) larva L3 puffstage 7-9  (988) white prepupae new  (874) white prepupae 12hr  (1598) white prepupae 24hr  (1247) pupae 2d postWPP  (257) pupae 3d postWPP  (127) pupae 4d postWPP  (169) adult male 01day  (135) adult male 05day  (229) adult male 30day  (199) adult female 01day  (596) adult female 05day  (1437) adult female 30day  (1617) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (4029) embryo 02-04hr  (7637) embryo 04-06hr  (10553) embryo 06-08hr  (9537) embryo 08-10hr  (6598) embryo 10-12hr  (2948) embryo 12-14hr  (2238) embryo 14-16hr  (1611) embryo 16-18hr    1219 embryo 18-20hr    595 embryo 20-22hr  (2302) embryo 22-24hr  (1876) larva L1    72 larva L2    122 larva L3 12hr old    226 larva L3 puffstage 1-2    587 larva L3 puffstage 3-6    944 larva L3 puffstage 7-9    988 white prepupae new    874 white prepupae 12hr  (1598) white prepupae 24hr    1247 pupae 2d postWPP    257 pupae 3d postWPP    127 pupae 4d postWPP    169 adult male 01day    135 adult male 05day    229 adult male 30day    199 adult female 01day    596 adult female 05day  1437 adult female 30day  (1617) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    4029 embryo 02-04hr    7637 embryo 04-06hr  10553 embryo 06-08hr    9537 embryo 08-10hr    6598 embryo 10-12hr    2948 embryo 12-14hr    2238 embryo 14-16hr    1611 embryo 16-18hr    1219 embryo 18-20hr    595 embryo 20-22hr    2302 embryo 22-24hr    1876 larva L1    72 larva L2    122 larva L3 12hr old    226 larva L3 puffstage 1-2    587 larva L3 puffstage 3-6    944 larva L3 puffstage 7-9    988 white prepupae new    874 white prepupae 12hr    1598 white prepupae 24hr    1247 pupae 2d postWPP    257 pupae 3d postWPP    127 pupae 4d postWPP    169 adult male 01day    135 adult male 05day    229 adult male 30day    199 adult female 01day    596 adult female 05day    1437 adult female 30day    1617 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    4029 embryo 02-04hr    7637 embryo 04-06hr    10553 embryo 06-08hr    9537 embryo 08-10hr    6598 embryo 10-12hr    2948 embryo 12-14hr    2238 embryo 14-16hr    1611 embryo 16-18hr    1219 embryo 18-20hr    595 embryo 20-22hr    2302 embryo 22-24hr    1876 larva L1    72 larva L2    122 larva L3 12hr old    226 larva L3 puffstage 1-2    587 larva L3 puffstage 3-6    944 larva L3 puffstage 7-9    988 white prepupae new    874 white prepupae 12hr    1598 white prepupae 24hr    1247 pupae 2d postWPP    257 pupae 3d postWPP    127 pupae 4d postWPP    169 adult male 01day    135 adult male 05day    229 adult male 30day    199 adult female 01day    596 adult female 05day    1437 adult female 30day    1617 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0002466 expression level Developmental Stage   Expression Level embryo 00-02hr    4029 embryo 02-04hr    7637 embryo 04-06hr    10553 embryo 06-08hr    9537 embryo 08-10hr    6598 embryo 10-12hr    2948 embryo 12-14hr    2238 embryo 14-16hr    1611 embryo 16-18hr    1219 embryo 18-20hr    595 embryo 20-22hr    2302 embryo 22-24hr    1876 larva L1    72 larva L2    122 larva L3 12hr old    226 larva L3 puffstage 1-2    587 larva L3 puffstage 3-6    944 larva L3 puffstage 7-9    988 white prepupae new    874 white prepupae 12hr    1598 white prepupae 24hr    1247 pupae 2d postWPP    257 pupae 3d postWPP    127 pupae 4d postWPP    169 adult male 01day    135 adult male 05day    229 adult male 30day    199 adult female 01day    596 adult female 05day    1437 adult female 30day    1617 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (4029) embryo 02-04hr  (7637) embryo 04-06hr  (10553) embryo 06-08hr  (9537) embryo 08-10hr  (6598) embryo 10-12hr  (2948) embryo 12-14hr  (2238) embryo 14-16hr  (1611) embryo 16-18hr  (1219) embryo 18-20hr  (595) embryo 20-22hr  (2302) embryo 22-24hr  (1876) larva L1    72 larva L2  122 larva L3 12hr old  (226) larva L3 puffstage 1-2  (587) larva L3 puffstage 3-6  (944) larva L3 puffstage 7-9  (988) white prepupae new  (874) white prepupae 12hr  (1598) white prepupae 24hr  (1247) pupae 2d postWPP  (257) pupae 3d postWPP  127 pupae 4d postWPP  (169) adult male 01day  135 adult male 05day  (229) adult male 30day  (199) adult female 01day  (596) adult female 05day  (1437) adult female 30day  (1617) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (4029) embryo 02-04hr  (7637) embryo 04-06hr  (10553) embryo 06-08hr  (9537) embryo 08-10hr  (6598) embryo 10-12hr  (2948) embryo 12-14hr  2238 embryo 14-16hr  1611 embryo 16-18hr    1219 embryo 18-20hr    595 embryo 20-22hr  2302 embryo 22-24hr  1876 larva L1    72 larva L2    122 larva L3 12hr old    226 larva L3 puffstage 1-2    587 larva L3 puffstage 3-6    944 larva L3 puffstage 7-9    988 white prepupae new    874 white prepupae 12hr  1598 white prepupae 24hr    1247 pupae 2d postWPP    257 pupae 3d postWPP    127 pupae 4d postWPP    169 adult male 01day    135 adult male 05day    229 adult male 30day    199 adult female 01day    596 adult female 05day  1437 adult female 30day  1617 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    4029 embryo 02-04hr    7637 embryo 04-06hr  10553 embryo 06-08hr    9537 embryo 08-10hr    6598 embryo 10-12hr    2948 embryo 12-14hr    2238 embryo 14-16hr    1611 embryo 16-18hr    1219 embryo 18-20hr    595 embryo 20-22hr    2302 embryo 22-24hr    1876 larva L1    72 larva L2    122 larva L3 12hr old    226 larva L3 puffstage 1-2    587 larva L3 puffstage 3-6    944 larva L3 puffstage 7-9    988 white prepupae new    874 white prepupae 12hr    1598 white prepupae 24hr    1247 pupae 2d postWPP    257 pupae 3d postWPP    127 pupae 4d postWPP    169 adult male 01day    135 adult male 05day    229 adult male 30day    199 adult female 01day    596 adult female 05day    1437 adult female 30day    1617 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    4029 embryo 02-04hr    7637 embryo 04-06hr    10553 embryo 06-08hr    9537 embryo 08-10hr    6598 embryo 10-12hr    2948 embryo 12-14hr    2238 embryo 14-16hr    1611 embryo 16-18hr    1219 embryo 18-20hr    595 embryo 20-22hr    2302 embryo 22-24hr    1876 larva L1    72 larva L2    122 larva L3 12hr old    226 larva L3 puffstage 1-2    587 larva L3 puffstage 3-6    944 larva L3 puffstage 7-9    988 white prepupae new    874 white prepupae 12hr    1598 white prepupae 24hr    1247 pupae 2d postWPP    257 pupae 3d postWPP    127 pupae 4d postWPP    169 adult male 01day    135 adult male 05day    229 adult male 30day    199 adult female 01day    596 adult female 05day    1437 adult female 30day    1617 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0002466    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0002466 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: larval central nervous system, adult ovary. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0002466 expression level Tissue   Expression Level Larval Central Nervous System    427.325 Larval Midgut no informative data Larval Hindgut    16.3 Larval Malpighian Tubules    3.7 Larval Fat Body no informative data Larval Salivary Gland no informative data Larval Trachea    58.525 Larval Carcass    38.075 Adult Head    4.7 Adult Eye    2.275 Adult Brain    1.1 Adult Thoracic-Abdominal Ganglion    6 Adult Crop    3.4 Adult Midgut    7.3 Adult Hindgut    1.9 Adult Malpighian Tubules    3.6 Adult Fat Body    6.2 Adult Salivary Gland    8.3 Adult Heart    3.775 Adult VirginFemale Spermatheca    3.1 Adult InseminatedFemale Spermatheca    4.4 Adult Ovary    252.5 Adult Testis    57 Adult Male Accessory Gland    1.6 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    427.325 Larval Midgut no informative data Larval Hindgut    16.3 Larval Malpighian Tubules    3.7 Larval Fat Body no informative data Larval Salivary Gland no informative data Larval Trachea    58.525 Larval Carcass    38.075 Adult Head    4.7 Adult Eye    2.275 Adult Brain    1.1 Adult Thoracic-Abdominal Ganglion    6 Adult Crop    3.4 Adult Midgut    7.3 Adult Hindgut    1.9 Adult Malpighian Tubules    3.6 Adult Fat Body    6.2 Adult Salivary Gland    8.3 Adult Heart    3.775 Adult VirginFemale Spermatheca    3.1 Adult InseminatedFemale Spermatheca    4.4 Adult Ovary    252.5 Adult Testis    57 Adult Male Accessory Gland    1.6 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    427.325 Larval Midgut no informative data Larval Hindgut    16.3 Larval Malpighian Tubules    3.7 Larval Fat Body no informative data Larval Salivary Gland no informative data Larval Trachea    58.525 Larval Carcass    38.075 Adult Head    4.7 Adult Eye    2.275 Adult Brain    1.1 Adult Thoracic-Abdominal Ganglion    6 Adult Crop    3.4 Adult Midgut    7.3 Adult Hindgut    1.9 Adult Malpighian Tubules    3.6 Adult Fat Body    6.2 Adult Salivary Gland    8.3 Adult Heart    3.775 Adult VirginFemale Spermatheca    3.1 Adult InseminatedFemale Spermatheca    4.4 Adult Ovary    252.5 Adult Testis    57 Adult Male Accessory Gland    1.6 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    427.325 Larval Midgut no informative data Larval Hindgut    16.3 Larval Malpighian Tubules    3.7 Larval Fat Body no informative data Larval Salivary Gland no informative data Larval Trachea    58.525 Larval Carcass    38.075 Adult Head    4.7 Adult Eye    2.275 Adult Brain    1.1 Adult Thoracic-Abdominal Ganglion    6 Adult Crop    3.4 Adult Midgut    7.3 Adult Hindgut    1.9 Adult Malpighian Tubules    3.6 Adult Fat Body    6.2 Adult Salivary Gland    8.3 Adult Heart    3.775 Adult VirginFemale Spermatheca    3.1 Adult InseminatedFemale Spermatheca    4.4 Adult Ovary    252.5 Adult Testis    57 Adult Male Accessory Gland    1.6 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0002466 expression level Tissue   Expression Level Larval Central Nervous System    427.325 Larval Midgut no informative data Larval Hindgut    16.3 Larval Malpighian Tubules    3.7 Larval Fat Body no informative data Larval Salivary Gland no informative data Larval Trachea    58.525 Larval Carcass    38.075 Adult Head    4.7 Adult Eye    2.275 Adult Brain    1.1 Adult Thoracic-Abdominal Ganglion    6 Adult Crop    3.4 Adult Midgut    7.3 Adult Hindgut    1.9 Adult Malpighian Tubules    3.6 Adult Fat Body    6.2 Adult Salivary Gland    8.3 Adult Heart    3.775 Adult VirginFemale Spermatheca    3.1 Adult InseminatedFemale Spermatheca    4.4 Adult Ovary    252.5 Adult Testis    57 Adult Male Accessory Gland    1.6 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    427.325 Larval Midgut no informative data Larval Hindgut    16.3 Larval Malpighian Tubules    3.7 Larval Fat Body no informative data Larval Salivary Gland no informative data Larval Trachea    58.525 Larval Carcass    38.075 Adult Head    4.7 Adult Eye    2.275 Adult Brain    1.1 Adult Thoracic-Abdominal Ganglion    6 Adult Crop    3.4 Adult Midgut    7.3 Adult Hindgut    1.9 Adult Malpighian Tubules    3.6 Adult Fat Body    6.2 Adult Salivary Gland    8.3 Adult Heart    3.775 Adult VirginFemale Spermatheca    3.1 Adult InseminatedFemale Spermatheca    4.4 Adult Ovary    252.5 Adult Testis    57 Adult Male Accessory Gland    1.6 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    427.325 Larval Midgut no informative data Larval Hindgut    16.3 Larval Malpighian Tubules    3.7 Larval Fat Body no informative data Larval Salivary Gland no informative data Larval Trachea    58.525 Larval Carcass    38.075 Adult Head    4.7 Adult Eye    2.275 Adult Brain    1.1 Adult Thoracic-Abdominal Ganglion    6 Adult Crop    3.4 Adult Midgut    7.3 Adult Hindgut    1.9 Adult Malpighian Tubules    3.6 Adult Fat Body    6.2 Adult Salivary Gland    8.3 Adult Heart    3.775 Adult VirginFemale Spermatheca    3.1 Adult InseminatedFemale Spermatheca    4.4 Adult Ovary    252.5 Adult Testis    57 Adult Male Accessory Gland    1.6 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    427.325 Larval Midgut no informative data Larval Hindgut    16.3 Larval Malpighian Tubules    3.7 Larval Fat Body no informative data Larval Salivary Gland no informative data Larval Trachea    58.525 Larval Carcass    38.075 Adult Head    4.7 Adult Eye    2.275 Adult Brain    1.1 Adult Thoracic-Abdominal Ganglion    6 Adult Crop    3.4 Adult Midgut    7.3 Adult Hindgut    1.9 Adult Malpighian Tubules    3.6 Adult Fat Body    6.2 Adult Salivary Gland    8.3 Adult Heart    3.775 Adult VirginFemale Spermatheca    3.1 Adult InseminatedFemale Spermatheca    4.4 Adult Ovary    252.5 Adult Testis    57 Adult Male Accessory Gland    1.6 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut no informative data Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body no informative data Larval Salivary Gland no informative data Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass no informative data FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    4.7   NA  Eye    2.275   NA  Brain    1.1   427.325  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    6   NA  Crop    3.4   no informative data  Midgut    7.3   16.3  Hindgut    1.9   3.7  Malpighian Tubules    3.6   no informative data  Fat Body    6.2   no informative data  Salivary Gland    8.3   NA  Heart    3.775   58.525  Trachea    NA   NA  VirginFemale Spermatheca    3.1   NA  InseminatedFemale Spermatheca    4.4   NA  Ovary    252.5   NA  Testis    57   NA  Male Accessory Gland    1.6   38.075  Carcass    no informative data modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_17
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0002466 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG10522-RA FlyExpress - Embryonic expression images (BDGP data) • Show all FlyExpress processed images for sti Stages(s) 1-3 Stages(s) 4-6 Stages(s) 9-10 Stages(s) 11-12 Stages(s) 13-16
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal | heat sensitive (with sti3) stiZ3-5829 lethal | heat sensitive (with stiZ3-5829) sti3 lethal | larval stage | recessive sti1 lethal | prepupal stage sti1 sti4 lethal | prepupal stage (with Df(3L)F10) sti1 sti2 sti4 lethal | prepupal stage (with sti1) sti2 sti3 sti4 lethal | prepupal stage (with sti2) sti1 sti3 sti4 lethal | prepupal stage (with sti3) sti1 sti2 sti4 lethal | prepupal stage (with sti4) sti1 sti2 sti3 lethal | P-stage | recessive stiCMV111 stiIV61 lethal | pupal stage stiGS9053 stiKG01697 lethal | pupal stage (with Df(3L)iro-2) stiGS9053 stiKG01697 lethal | pupal stage (with stiGS9053) stiKG01697 lethal | pupal stage (with stiKG01697) stiGS9053 lethal | recessive stiD97 lethal | recessive | heat sensitive stiZ3-5829 lethal | third instar larval stage (with Df(3L)F10) sti3 semi-lethal | adult stage sti5 semi-lethal | adult stage (with Df(3L)F10) sti5 semi-lethal | adult stage (with sti1) sti5 semi-lethal | adult stage (with sti2) sti5 semi-lethal | adult stage (with sti3) sti5 semi-lethal | adult stage (with sti4) sti5 semi-lethal | adult stage (with sti5) sti1 sti2 sti3 sti4 semi-lethal | larval stage stiGS9053 stiKG01697 semi-lethal | larval stage (with Df(3L)iro-2) stiGS9053 stiKG01697 semi-lethal | larval stage (with stiGS9053) stiKG01697 semi-lethal | larval stage (with stiKG01697) stiGS9053 semi-lethal | pharate adult stage (with Df(3L)F10) sti5 semi-lethal | pharate adult stage (with sti1) sti5 semi-lethal | pharate adult stage (with sti2) sti5 semi-lethal | pharate adult stage (with sti3) sti5 semi-lethal | pharate adult stage (with sti4) sti5 semi-lethal | pharate adult stage (with sti5) sti1 sti2 sti3 sti4 semi-lethal | prepupal stage (with Df(3L)F10) sti5 semi-lethal | pupal stage (with Df(3L)F10) sti5 semi-viable | adult stage sti5 viable stiZ3-5829 Sterility Allele female semi-sterile sti5 female sterile stiZ3-5829 male sterile sti5 Other Phenotypes Allele cytokinesis defective sti1 stidck2 stiKG01697 cytokinesis defective (with Df(3L)E44) stidck2 cytokinesis defective (with Df(3L)iro-2) stiGS9053 enhancer of variegation | recessive, with Dp(?;2)bwD/+: stiZ3-5829 mitotic cell cycle defective sti1 sti2 sti3 suppressor of variegation | dominant, with In(1)wm4h sti3 stiZ3-5829 suppressor of variegation | dominant, with P{lacW}50C.x6 sti3 stiZ3-5829 visible | heat sensitive (with sti3) stiZ3-5829 visible | heat sensitive (with stiZ3-5829) sti3 visible | recessive stiZ3-5829 Phenotype manifest in Allele actomyosin contractile ring | ectopic stidsRNA.cDa chromosome | ectopic stidsRNA.cDa embryonic/larval brain stiZ3-5829 embryonic/larval brain (with Df(3L)iro-2) stiGS9053 embryonic/larval brain | third instar larval stage stiCMV111 stiIV61 embryonic/larval neuroblast | third instar larval stage stiCMV111 stiIV61 embryonic peripheral nervous system & neuron (with Df(3L)iro-2) stiGS9053 eye stiZ3-5829 eye, with Scer\GAL4ey.PB stidsRNA.Sym.Scer\UAS eye, with Scer\GAL4ey.PB, sti3 stidsRNA.Sym.Scer\UAS eye, with Scer\GAL4ey.PB, stidsRNA.Sym.Scer\UAS sti3 eye & ommatidium sti3 eye | heat sensitive (with sti3) stiZ3-5829 eye | heat sensitive (with stiZ3-5829) sti3 filamentous actin stidsRNA.cDa follicle cell stiZ3-5829 imaginal disc sti1 sti2 sti4 imaginal disc (with Df(3L)F10) sti1 sti2 sti4 imaginal disc (with Df(3L)iro-2) stiGS9053 imaginal disc (with sti1) sti3 sti4 imaginal disc (with sti2) sti3 sti4 imaginal disc (with sti3) sti1 sti2 sti4 imaginal disc (with sti4) sti1 sti2 sti3 interommatidial bristle stiZ3-5829 interommatidial bristle | heat sensitive (with sti3) stiZ3-5829 interommatidial bristle | heat sensitive (with stiZ3-5829) sti3 neuroblast & chromosome sti1 neuroblast & chromosome (with Df(3L)F10) sti4 sti5 neuroblast & chromosome (with sti1) sti4 sti5 neuroblast & chromosome (with sti4) sti1 sti5 neuroblast & chromosome (with sti5) sti1 sti4 neuroblast & condensed chromosome sti1 neuroblast | third instar larval stage sti1 neuroblast | third instar larval stage (with Df(3L)F10) sti4 sti5 neuroblast | third instar larval stage (with sti1) sti4 sti5 neuroblast | third instar larval stage (with sti4) sti1 sti5 neuroblast | third instar larval stage (with sti5) sti1 sti4 nucleus stidsRNA.cDa nucleus, with Scer\GAL4ey.PB stidsRNA.Sym.Scer\UAS nucleus & follicle cell | conditional - heat sensitive stiZ3-5829 nucleus & follicle cell | conditional - heat sensitive (with sti3) stiZ3-5829 nucleus & follicle cell | conditional - heat sensitive (with stiZ3-5829) sti3 ommatidium, with Scer\GAL4ey.PB stidsRNA.Sym.Scer\UAS ommatidium, with Scer\GAL4ey.PB, sti3 stidsRNA.Sym.Scer\UAS ommatidium, with Scer\GAL4ey.PB, stidsRNA.Sym.Scer\UAS sti3 presumptive embryonic/larval peripheral nervous system (with Df(3L)iro-2) stiGS9053 stiKG01697 S2 cell-line stidsRNA.cSa spermatid & Nebenkern stidck2 spermatid & Nebenkern (with Df(3L)E44) stidck2 spermatid & nucleus | supernumerary stidck2 spermatid & nucleus | supernumerary (with Df(3L)E44) stidck2 spermatocyte sti1 spermatocyte ring canal (with Df(3L)E44) stidck2 testis sti1
Classical Alleles ( 16 )
For All Classical Alleles Show
Allele of sti Class Mutagen Stocks Known lesion sti1 hypomorphic allele - genetic evidence ethyl methanesulfonate 2 Yes sti3 hypomorphic allele - genetic evidence ethyl nitrosourea 2 Yes stiKG01697 P-element activity 2 -- stiCB-6193-3 1 -- stiGS9053 1 Yes sti2 hypomorphic allele - genetic evidence ethyl nitrosourea 0 Yes sti4 hypomorphic allele - genetic evidence P-element activity 0 Yes sti5 hypomorphic allele - genetic evidence P-element activity 0 Yes stiCMV111 ethyl methanesulfonate 0 -- stiD97 ethyl methanesulfonate 0 -- stidck2 ethyl methanesulfonate 0 Yes stiIV61 ethyl methanesulfonate 0 -- stiPL00724 piggyBac transposase 0 Yes stiS050110 0 -- stisex204 P-element activity 0 -- stiZ3-5829 hypomorphic allele - genetic evidence 0 Yes
Alleles Carried on Transgenic Constructs ( 7 )
For All Alleles Carried on Transgenic Constructs Show
Allele of sti Class Mutagen Stocks Known lesion stiGL00312 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes stidsRNA.cDa in vitro construct - RNAi 0 -- stidsRNA.cHa in vitro construct - RNAi 0 -- stidsRNA.cSa in vitro construct - RNAi 0 Yes stidsRNA.Sym.Scer\UAS in vitro construct - RNAi 0 Yes stiGD7002 in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes stiScer\UAS.T:Avic\GFP in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(3L)E44 (Naim et al., 2004) Df(3L)ED4483 (Sweeney et al., 2008) Df(3L)eygC1 (Sweeney et al., 2008) Df(3L)F10 (D'Avino et al., 2004, Naim et al., 2004, Sweeney et al., 2008) Df(3L)iro-2 (Shandala et al., 2004, Naim et al., 2004) In(3LR)bxd113LC190R (Carpenter, 1994)
Partially disrupted in	Df(3L)sex204 (Carre et al., 2005)
Not disrupted in	Df(3L)ED215 (Sweeney et al., 2008) Df(3L)ED4475 (Sweeney et al., 2008) Df(3L)Exel6116 (Sweeney et al., 2008) Df(3L)Exel6117 (Sweeney et al., 2008)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD7002} NA P{Sym-UAS-sti-dsRNA} NA P{TRiP.GL00312} NA P{UAS-sti.GFP} NA
Insertions
	Type of insertions Name Expression data miscellaneous insertions H{}sti4 NA H{}sti5 NA P{RS3}stiCB-6193-3 NA P{SUPor-P}stiKG01697 NA insertion of enhancer trap binary system PBac{GAL4D,EYFP}stiPL00724 No insertion of mobile activating element P{GSV6}stiGS9053 NA
Gene Ontology: Function, Process & Cellular Component ( 13 unique terms )
Terms Based on Experimental Evidence ( 7 terms )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
chromatin organization inferred from mutant phenotype (Sweeney et al., 2008) cytokinesis inferred from mutant phenotype (Kiger et al., 2003, Rogers et al., 2003, Echard et al., 2004, Eggert et al., 2004, Sweeney et al., 2008) cytokinesis, actomyosin contractile ring assembly inferred from mutant phenotype (D'Avino et al., 2004) cytokinesis, completion of separation inferred from mutant phenotype (Naim et al., 2004) cytokinesis after mitosis inferred from mutant phenotype (Shandala et al., 2004) regulation of actin cytoskeleton organization inferred from mutant phenotype (Kunda et al., 2008)
Cellular Component
CV term Evidence References
actomyosin contractile ring inferred from direct assay (Shandala et al., 2004)
Terms Based on Predictions or Assertions ( 6 terms )
Molecular Function
CV term Evidence References
ATP binding inferred from electronic annotation with InterPro:IPR000719, InterPro:IPR000961, InterPro:IPR002290, InterPro:IPR017441, InterPro:IPR017892 (FlyBase Curators et al., 2004-) diacylglycerol binding inferred from sequence or structural similarity with InterPro:IPR002219 (FlyBase, 1992-) protein serine/threonine kinase activity inferred from sequence or structural similarity with EMBL:AF086824 (FlyBase, 1992-) non-traceable author statement (Morrison et al., 2000) small GTPase regulator activity inferred from electronic annotation with InterPro:IPR001180 (FlyBase Curators et al., 2004-)
Biological Process
CV term Evidence References
intracellular signal transduction inferred from electronic annotation with InterPro:IPR002219 (FlyBase Curators et al., 2004-) protein phosphorylation inferred from electronic annotation with InterPro:IPR000719, InterPro:IPR000961, InterPro:IPR002290, InterPro:IPR008271, InterPro:IPR017892 (FlyBase Curators et al., 2004-) non-traceable author statement (Morrison et al., 2000)
Cellular Component ( 0 terms)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions sti allele Gene References stiGS9053 pbl (Shandala et al., 2004) stiKG01697 pbl (Shandala et al., 2004) unspecified pbl (Gregory et al., 2007)
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 64778 DroID - A comprehensive database of gene and protein interactions. • FBgn0002466 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 39429
Orthologs
Genome-wide drosophilid orthologs	Dana\GF24009 Dere\GG13818 Dgri\GH16845 Dmoj\GI13065 Dper\GL24946 Dpse\GA10369 Dsec\GM24647 Dsim\GD12711 Dvir\GJ13813 Dwil\GK12619 Dyak\GE20113
Curated drosophilid orthologs	Dmir\CG10522 (Thornton, 2005.12.20) Dpse\GA10369
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL011879-PA Aedes aegypti (mosquito) AGAP006932-PA Anopheles gambiae (mosquito) XP_001943480.1 Acyrthosiphon pisum (pea aphid) BGIBMGA012856-PA Bombyx mori (silk worm) ENSCAFP00000014882 Canis familiaris (dog) Chro.70160 Cryptosporidium hominis (obligate parasite) CPIJ016714 Culex pipens (mosquito) ENSCPOP00000014787 Cavia porcellus (guinea pig) 229061 Daphnia pulex (daphnia) ENSECAP00000008623 Equus caballus (horse) ENSGACP00000011409 Gymnopilus aculeatus (mushroom) ENSGALP00000011881 Gallus gallus (chicken) ENSP00000376306 Homo sapiens (human) ENSMODP00000019064 Monodelphis domestica (gray opossum) ENSMMUP00000026115 Macaca mulatta (rhesus monkey) ENSMUSP00000107645 Mus musculus (house mouse) XP_001605786.1 Nasonia vitripennis (wasp) ENSORLP00000011397 Oryzias latipes (japanese killifish) PFC0485w Plasmodium falciparum (protozoal parasite) PHUM001875-PA Pediculus humanus (human body louse) PP10547 Pristionchus pacificus (nematode) ENSPPYP00000005720 Pongo pygmaeus (orangutan) ENSPTRP00000057114 Pan troglodytes (chimpanzee) ENSRNOP00000001509 Rattus norvegicus (norway rat) ENSTRUP00000040174 Takifugu rubripes (pufferfish Takifugu) 3690.m00013 Tetrahymena thermophila (ciliate protozoa) ENSXETP00000026596 Xenopus tropicalis (frog) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • FBgn0237436 FBgn0214628 FBgn0201032 FBgn0184438 FBgn0179510 JGI_V11_229061 FBgn0070426 FBgn0162533 FBgn0135822 FBgn0124316 FBgn0106081 FBgn0101003 CPIJ018912 BGIBMGA012856 ACYPI003248 PHUM573900 GLEAN_14999
Stocks & Reagents
Stocks Listed in FlyBase ( 9 )
Bloomington	35392 y1 sc* v1; P{TRiP.GL00312}attP2 4366 In(3LR)C190LUbx42TR, Ubx-/sti1 4871 sti3 rnroe-1 pp/TM3, Sb1 Ser1 13471 y1; P{SUPor-P}stiKG01697 ry506/TM3, Sb1 Ser1
Kyoto	123969 w1118; P{RS3}stiCB-6193-3 107708 In(3LR)C190LUbx42TR, Ubx-/sti1 107921 sti3 rnroe-1 pp/TM3, Sb1 Ser1 201488 y1 w67c23; P{GSV6}stiGS9053/TM3, Sb1 Ser1 111548 yd2 w1118 P{ey-FLP.N}2 P{GMR-lacZ.C(38.1)}TPN1; P{SUPor-P}stiKG01697 P{neoFRT}80B/TM6B, P{Car20y}TPN1, Tb1
Genomic Clones ( 1 )
	BACR48G06 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 38 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	RE26327
Other clones	FI02033
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	GM15231 LD04032 LD04221 LD09587 LD10685 LD18858 LD29418 LD33293 LP04355 RH42880 RH51781
Other clones	35107 56245 77286 79880 192224 214257.47 214417.43 214439.56 274340 Dmel_neb_015692_0698_1548 EC053060 EC054029 EK145456 EK167739 EK211938 EK265609 EK294650 EK301735 EP03349 EP12020 EP13937 EP14803 RM06882 RP003377287 SD06861
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0002466 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 39429
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of	Source for merge of: cit anon-WO0118547.388 (FlyBase, 1996-) Source for merge of: cit CG10522 (Shandala et al., 2004) Source for merge of: sti cit (Naim et al., 2004)
Additional comments	Source for merge of cit anon-WO0118547.388 was sequence comparison (date:051113). (FlyBase, 1996-)
Other Comments
	When dsRNA constructs are made and transiently transfected into S2 cells in RNAi experiments, a decrease in the ratio of cells in prometaphase and metaphase versus the total number of mitotic cells and a whole range of mitotic abnormalities are seen. (Bettencourt-Dias et al., 2004) Analysis of sti5 and sti2, reveal that the region between residues 1125 and 1178 is important for sti activity. (D'Avino et al., 2004) sti is required for the terminal (post-furrowing) events of cytokinesis. (Echard et al., 2004) dsRNA directed against this gene causes defects in cytokinesis when tested in an RNAi screen in S2 cells. (Echard et al., 2004) RNAi screen using dsRNA made from templates generated with primers directed against this gene causes a binucleation phenotype when assayed in Kc167 cells. (Eggert et al., 2004) dsRNA made from templates generated with primers directed against this gene causes a phenotype in S2 cells. These cells display higher frequencies of telophases, abnormal membrane protrusions at the cleavage furrow and lack the "Fleming body", a proteinaceous matrix associated with the central spindle midzone. (Naim et al., 2004) RNAi screen using dsRNA made from templates generated with primers directed against this gene causes a phenotype when assayed in Kc167 and S2R+ cells: binucleate cells. (Kiger et al., 2003) dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology. (Kiger et al., 2003) dsRNA made from templates generated with primers directed against this gene is tested in an RNAi screen for effects on actin-based lamella formation. (Rogers et al., 2003) Area matching Drosophila EST AA539198. (Davies, 2001.3.15) All alleles have mitotic chromosomes (both sisters and heterologues) stuck together and show metaphase delay; "successful" anaphase fragments the chromosomes. (Carpenter, 1994)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_140327 RefSeq (Proteins) • NP_648584 DDBJ / EMBL / GenBank • AA539198 AAF49907 AAQ23584 AX094264 BH740764 BI228701 BT010266 Entrez Gene - A searchable database of RefSeq genes. • 39429 UniProtKB/TrEMBL • Q6NR17 Q9VTY8
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Protein kinase, catalytic domain (IPR000719) AGC-kinase, C-terminal (IPR000961) Citron-like (IPR001180) Protein kinase C-like, phorbol ester/diacylglycerol binding (IPR002219) Serine/threonine-protein kinase, catalytic domain (IPR002290) Serine/threonine-protein kinase, active site (IPR008271) Protein kinase-like domain (IPR011009) Protein kinase, ATP binding site (IPR017441) Serine/threonine-protein kinase-like domain (IPR017442) Protein kinase, C-terminal (IPR017892)
Linkouts
	BioGRID - A database of protein and genetic interactions • 64778 DroID - A comprehensive database of gene and protein interactions. • FBgn0002466 DRSC - Results from RNAi screens. • FBgn0002466 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0002466 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG10522-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0002466 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 39429 InParanoid A subset of ortholog calls from InParanoid. • AAEL011879-PA Aedes aegypti (mosquito) AGAP006932-PA Anopheles gambiae (mosquito) XP_001943480.1 Acyrthosiphon pisum (pea aphid) BGIBMGA012856-PA Bombyx mori (silk worm) ENSCAFP00000014882 Canis familiaris (dog) Chro.70160 Cryptosporidium hominis (obligate parasite) CPIJ016714 Culex pipens (mosquito) ENSCPOP00000014787 Cavia porcellus (guinea pig) 229061 Daphnia pulex (daphnia) ENSECAP00000008623 Equus caballus (horse) ENSGACP00000011409 Gymnopilus aculeatus (mushroom) ENSGALP00000011881 Gallus gallus (chicken) ENSP00000376306 Homo sapiens (human) ENSMODP00000019064 Monodelphis domestica (gray opossum) ENSMMUP00000026115 Macaca mulatta (rhesus monkey) ENSMUSP00000107645 Mus musculus (house mouse) XP_001605786.1 Nasonia vitripennis (wasp) ENSORLP00000011397 Oryzias latipes (japanese killifish) PFC0485w Plasmodium falciparum (protozoal parasite) PHUM001875-PA Pediculus humanus (human body louse) PP10547 Pristionchus pacificus (nematode) ENSPPYP00000005720 Pongo pygmaeus (orangutan) ENSPTRP00000057114 Pan troglodytes (chimpanzee) ENSRNOP00000001509 Rattus norvegicus (norway rat) ENSTRUP00000040174 Takifugu rubripes (pufferfish Takifugu) 3690.m00013 Tetrahymena thermophila (ciliate protozoa) ENSXETP00000026596 Xenopus tropicalis (frog) Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution • /sturtevant/citron1.htm InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 39429 modMine - Data generated by the modENCODE project. • FBgn0002466 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • FBgn0237436 FBgn0214628 FBgn0201032 FBgn0184438 FBgn0179510 JGI_V11_229061 FBgn0070426 FBgn0162533 FBgn0135822 FBgn0124316 FBgn0106081 FBgn0101003 CPIJ018912 BGIBMGA012856 ACYPI003248 PHUM573900 GLEAN_14999
Synonyms & Secondary IDs ( 21 )
Reported As
Symbol Synonym	anon-WO0118547.388   CG10522 (Bettencourt-Dias et al., 2004, Naim et al., 2004, Eggert et al., 2004, Shandala et al., 2004, Echard et al., 2004, Hacker et al., 2003, Egger et al., 2002, Brody et al., 2002, Asha et al., 2003, Kiger et al., 2003, Kiger et al., 2003, Dimova et al., 2003, Ross-Macdonald, 2001.4.3, Giot et al., 2003, Hickson et al., 2006, Rogers et al., 2003, Sweeney et al., 2008, Ni et al., 2011.7.19) cit (Shandala et al., 2004, Rogers et al., 2003, Hickson et al., 2006) CIT-K (D'Avino et al., 2005) Citron K (Piekny et al., 2005) dck (Naim et al., 2004, Wilhelm et al., 2005) DCK (D'Avino et al., 2005) l(3)7m62 (Bloomington Drosophila Stock Center, 1998.1.9, Fuller, 1993, Glover, 1990) l(3)7m-62 (Schweisguth et al., 1991, Gatti and Baker, 1989, Castellanos et al., 2008) l(3)SG21   sti (Sweeney et al., 2008, Carpenter and D'Avino, 2004.9.30, D'Avino et al., 2004, Somma et al., 2008, Slack et al., 2006) STI (D'Avino et al., 2005)
Name Synonym	Citron (O'Farrell et al., 2004, Settleman, 2001, Morrison et al., 2000, Gregory et al., 2007, Dean and Spudich, 2006, Kunda et al., 2008) CITRON (Morrison et al., 2000) citron (Shandala et al., 2004, Hickson et al., 2006, Gregory et al., 2007) citron kinase (Echard et al., 2004, Rogers et al., 2003, Gregory et al., 2007, Somma et al., 2008) Citron kinase (Rogers et al., 2003) Citron Kinase (Dean and Spudich, 2006) Drosophila citron kinase (Naim et al., 2004) sticky (Sweeney et al., 2008, Rocha et al., 2011, Slack et al., 2006) Sticky (D'Avino et al., 2005)
Secondary FlyBase IDs
	FBgn0036295 FBgn0062046
References ( 61 )
Generate a list of	All references relating to this gene ( 61 )
List References by type	Research paper  ( 30 ) Supplementary material  ( 6 ) Review  ( 6 ) Personal communication to FlyBase  ( 5 ) Abstract  ( 2 ) FlyBase analysis  ( 3 ) Patent  ( 1 ) Stock list  ( 1 ) DNA/RNA sequence record  ( 2 ) Computer file  ( 2 ) Automatic genome annotation  ( 1 ) Book  ( 1 ) Curated genome annotation  ( 1 )
Recent research papers ( 2 )
	Bassi et al., 2011, J. Cell Biol. 195(4): 595--603 Sticky/Citron kinase maintains proper RhoA localization at the cleavage site during cytokinesis. [FBrf0216679] Rocha et al., 2011, PLoS ONE 6(4): e19087 A Phagocytic Route for Uptake of Double-Stranded RNA in RNAi. [FBrf0213678] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2010 Show reviews ...