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Gene Dmel\Lam

General Information
Symbol	Dmel\Lam	Species	D. melanogaster
Name	Lamin	Annotation symbol	CG6944
Feature type	protein_coding_gene	FlyBase ID	FBgn0002525
Gene Model Status	Current	Stock availability	15 publicly available
Also Known As	Dm0, lamin Dm0, Dm0, DmO, Dm1, lamDm0, Dm2, l(2)04643, Dmmit, jf27
Genomic Location
Chromosome (arm)	2L	Recombination map
Cytogenetic map	25E6-25E6	Sequence location	2L:5,542,544..5,546,642 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Lamin is referred to in FlyBase by the symbol Dmel\Lam (CG6944, FBgn0002525). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: protein binding. There is experimental evidence for 12 unique biological process terms, many of which group under: anatomical structure development; cellular component organization or biogenesis; organelle organization; multicellular organismal process; organ morphogenesis; membrane organization; cell-cell signaling; localization; biological regulation; regulation of cellular macromolecule biosynthetic process; sensory organ development; chitin-based cuticle development; open tracheal system development; cell cycle; central nervous system development; cell fate commitment; digestive tract development; cellular localization. 36 alleles are reported. The phenotypes of these alleles are annotated with: nuclear part; organ system; envelope; external compound sense organ; non-connected developing system; nucleus; organ system subdivision; late extended germ band embryo; sensillum; rhabdomere; dorsal branch primordium; eo support cell; ganglionic branch primordium; spermatozoon; female germline cyst. It has 3 annotated transcripts and 3 annotated polypeptides. Protein features are: Filament; Intermediate filament protein; Intermediate filament, C-terminal. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of moderate expression. Peak expression observed within 00-18 hour embryonic stages. Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: larval central nervous system, larval trachea. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, adult central nervous system, adult crop, larval hindgut, adult heart, larval salivary gland, adult female reproductive system, adult male reproductive system, larval carcass. Comments on Affy2 ProbeSet: ProbeSet 1636809_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of Lam. Gene sequence location is 2L:5542544..5546642.
External Summaries
Phenotypic Description from the Red Book (Lindsley & Zimm 1992)
Gene/Allele symbols may differ from current usage	Lam: Lamin The structural gene for nuclear lamin. Translated as a prolamin of apparent molecular mass of 76-kd, which is quickly processed to a 74-kd species, presumably by proteolysis. The processed polypeptide is assembled into the nuclear envelope, where it becomes phosphorylated and again attains a mass of 76 kd (Smith, Gruenbaum, Berrios, and Fisher, 1987, J. Cell Biol. 105: 771-90).
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2011_10	References Wang et al., 2011, PLoS Genet. 7(8): e1002227 Maruyama et al., 2011, PLoS ONE 6(6): e20901
FB2012_01	Controlled Vocabulary Terms mitotic spindle centrosome organization centrosome References Polychronidou et al., 2010, Mol. Biol. Cell 21(19): 3409--3420 Müller et al., 2010, EMBO J. 29(19): 3344--3357 Lancaster et al., 2010, PLoS Genet. 6(10): e1001179 Capalbo et al., 2011, Proc. Natl. Acad. Sci. U.S.A. 108(42): 17343--17348 Sequence features BKN22480 HFA03359
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 25E6-25E6   Limits computationally determined from genome sequence between P{lacW}Hel25Ek11511 and P{lacW}l(2)k06502k06502
Experimentally Determined Cytological Location
Cytogenetic map Notes References 25E5-25E6   (determined by in situ hybridisation)   (Spradling et al., 1999) 25E4-25E6   25F1--2   (BDGP Project Members, 1994-1999) 25F1-25F2   (determined by in situ hybridisation)   (Gruenbaum et al., 1988)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\Lam for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Lam-RA FBtr0079100  NM_057268   3127   622 Lam-RB FBtr0307058     3215   622 Lam-RC FBtr0307059     3624   622
Additional Transcript Data & Comments
Reported size (kB)	3.0, 2.8 (northern blot) (Gruenbaum et al., 1988)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Lam-PA   FBpp0078733   71.3   622   6.40     NP_476616   AAF52262 Lam-PB   FBpp0297901   71.3   622   6.40       Lam-PC   FBpp0297902   71.3   622   6.40
Additional Polypeptide Data & Comments
Reported size (kDa)	622 (aa); 76 (kD observed); 71 (kD predicted) (Gruenbaum et al., 1988)
Comments	The 76 kD Lam polypeptide is post-translationally modified to give a 74 kD form. (Gruenbaum et al., 1988)
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Intermediate filament, C-terminal (IPR001322) Intermediate filament protein (IPR001664) Filament (IPR016044)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA263866   AA264919   AA391522   AA392198   AA439869   AA536273   AA539938   AA539968   AA697025   AA942106   AA949067   AA949619   AE014134 AAF52262   AC009910   AI238090   AI258219   AI514678   AI518515   AI531713   AI532792   AI534248   AI541863   AI542657   AI543526   AI544028   AI544054   AI546621   AQ025968   AQ034028   AX664513 CAD80036   BE976992   BF486626   BG639187   BG639499   BI162086   BI170176   BI212173   BI227873   BI231720   BI237307   BI243854   BI353503   BI369860   BI370884   BI633014   BI640316   BP550516   BP550517   BT001506 AAN71261   CK657329   CL526005   CO178745   CO186701   CO190402   CO190907   CO262029   CO267646   CO271029   CO271133   CO272492   CO274242   CO274738   CO276659   CO277105   CO278530   CO282914   CO285134   CO289498   CO291814   CO292368   CO293357   CO298008   CO302097   CO305205   CO307389   CO309884   CO310872   CO311681   CO315512   CO317550   CO318950   CO319255   CO319257   CO323422   CO329410   CO329746   CO329819   CO330846   CO333638   CO335367   CS133217   EC060241   EC060356   EC062625   EC063136   EC066808   EC067367   EC071414   EC076486   EC077643   EC080867   EC081263   EC082687   EC087648   EC089708   EC194690   EC200386   EC201246   EC204341   EC204396   EC206333   EC208653   EC215190   EC215193   EC215463   EC216221   EC220545   EC222107   EC222967   EC223306   EC226452   EC227232   EC228341   EC229999   EC231466   EC232448   EC233636   EC234376   EC236647   EC236826   EC236831   EC237425   EC237788   EC238860   EC238987   EC242886   EC245511   EC246945   EC247875   EC267687   EV594157   G00464   GH747783   GH755025   GH760621   GH761110   GH770463   GH789104   GH803000   GH813399   GH819027   GH864535   GH871535   GH885335   GH887505   GH887789   GH896219   GH900439   GH904175   GH919742   GH922524   GH922869   GH927040   GH932494   X07278 CAA30259   X16275 CAA34351
UniProtKB/Swiss-Prot	P08928
UniProtKB/TrEMBL
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References insertion site P{lacW}Lam[k11511] 2L:5,542,255..5,542,262 evidence=experimental (BDGP Project Members, 1994-1999)
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
northern blot Stage Tissue/Position (including subcellular localization) Reference embryonic stage     (Riemer et al., 1995) embryonic stage -- adult stage     (Riemer et al., 1995, Gruenbaum et al., 1988)
Additional Descriptive Data
	The 3.0 kb Lam transcript is expressed at all stages, from embryo to adult. Although the 2.8 kb Lam transcript predominates in late oogenesis and early embryogenesis, the 3.0 kb transcript predominates starting at 2-3 hours of embryogenesis. Both transcripts encode the same polypeptide, and differ in their 3'-untranslated regions. (Gruenbaum et al., 1988)
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
immunolocalization Stage Tissue/Position (including subcellular localization) Reference embryonic stage | early     (Harel et al., 1989) embryonic stage -- adult stage     (Ashery-Padan et al., 1997) prepupal stage P4 -- pupal stage P5   salivary gland   • nucleus (Martin and Baehrecke, 2004) Comment:8-14 hr APF; full-length 76 kD Lamin pupal stage P5   salivary gland   • cytoplasm (Martin and Baehrecke, 2004) Comment:12-14 hr APF; cleaved 45 kD Lamin spermatogenesis & adult stage | male   spermatid cyst   • membrane | subset (Arama et al., 2003) oogenesis     (Ashery-Padan et al., 1997) mass spectroscopy Stage Tissue/Position (including subcellular localization) Reference day 7 of adulthood -- day 49 of adulthood   adult heart   (Cammarato et al., 2011) western blot Stage Tissue/Position (including subcellular localization) Reference embryonic stage     (Riemer et al., 1995) embryonic stage -- adult stage     (Riemer et al., 1995) larval stage     (Riemer et al., 1995) prepupal stage P4 -- pupal stage P5   salivary gland   (Martin and Baehrecke, 2004) Comment:8-14 hr APF; full-length 76 kD Lamin pupal stage P5   salivary gland   (Martin and Baehrecke, 2004) Comment:12-14 hr APF; cleaved 45 kD Lamin
Additional Descriptive Data
	Lam protein is a component of the individualization complex in late spermatogenesis. (Harel et al., 1989, Arama et al., 2003) Lam protein is nuclear. There is some, but not complete, overlap in subcellular Lam and LamC protein expression. (Martin and Baehrecke, 2004, Riemer et al., 1995) Lam protein localizes to the nucleus during early embryogenesis. (Ashery-Padan et al., 1997, Harel et al., 1989) Starting with 0-3 hr embryos, Lam protein is detected in all developmental stages. In embryo and larvae, expression is detected in all nuclei. (Riemer et al., 1995)
Marker for
Subcellular Localization
CV Term	nucleus nucleoplasm cytoplasm (Ashery-Padan et al., 1997) nucleus (Riemer et al., 1995) nuclear envelope (Harel et al., 1989)
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0002525    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0002525 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of moderate expression. Peak expression observed within 00-18 hour embryonic stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0002525 expression level Developmental Stage   Expression Level embryo 00-02hr    10643 embryo 02-04hr    19594 embryo 04-06hr    29163 embryo 06-08hr    35264 embryo 08-10hr    28514 embryo 10-12hr    30150 embryo 12-14hr    16827 embryo 14-16hr    13550 embryo 16-18hr    7720 embryo 18-20hr    4676 embryo 20-22hr    3045 embryo 22-24hr    3019 larva L1    5027 larva L2    3705 larva L3 12hr old    1970 larva L3 puffstage 1-2    2533 larva L3 puffstage 3-6    4820 larva L3 puffstage 7-9    5453 white prepupae new    5533 white prepupae 12hr    5856 white prepupae 24hr    9405 pupae 2d postWPP    4209 pupae 3d postWPP    2210 pupae 4d postWPP    1287 adult male 01day    1389 adult male 05day    2118 adult male 30day    1911 adult female 01day    3943 adult female 05day    5439 adult female 30day    5646 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (10643) embryo 02-04hr  (19594) embryo 04-06hr  (29163) embryo 06-08hr  (35264) embryo 08-10hr  (28514) embryo 10-12hr  (30150) embryo 12-14hr  (16827) embryo 14-16hr  (13550) embryo 16-18hr  (7720) embryo 18-20hr  (4676) embryo 20-22hr  (3045) embryo 22-24hr  (3019) larva L1  (5027) larva L2  (3705) larva L3 12hr old  (1970) larva L3 puffstage 1-2  (2533) larva L3 puffstage 3-6  (4820) larva L3 puffstage 7-9  (5453) white prepupae new  (5533) white prepupae 12hr  (5856) white prepupae 24hr  (9405) pupae 2d postWPP  (4209) pupae 3d postWPP  (2210) pupae 4d postWPP  (1287) adult male 01day  (1389) adult male 05day  (2118) adult male 30day  (1911) adult female 01day  (3943) adult female 05day  (5439) adult female 30day  (5646) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (10643) embryo 02-04hr  (19594) embryo 04-06hr  (29163) embryo 06-08hr  (35264) embryo 08-10hr  (28514) embryo 10-12hr  (30150) embryo 12-14hr  (16827) embryo 14-16hr  (13550) embryo 16-18hr  (7720) embryo 18-20hr  (4676) embryo 20-22hr  (3045) embryo 22-24hr  (3019) larva L1  (5027) larva L2  (3705) larva L3 12hr old  (1970) larva L3 puffstage 1-2  (2533) larva L3 puffstage 3-6  (4820) larva L3 puffstage 7-9  (5453) white prepupae new  (5533) white prepupae 12hr  (5856) white prepupae 24hr  (9405) pupae 2d postWPP  (4209) pupae 3d postWPP  (2210) pupae 4d postWPP    1287 adult male 01day    1389 adult male 05day  (2118) adult male 30day  (1911) adult female 01day  (3943) adult female 05day  (5439) adult female 30day  (5646) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr  10643 embryo 02-04hr  (19594) embryo 04-06hr  (29163) embryo 06-08hr  (35264) embryo 08-10hr  (28514) embryo 10-12hr  (30150) embryo 12-14hr  (16827) embryo 14-16hr  (13550) embryo 16-18hr    7720 embryo 18-20hr    4676 embryo 20-22hr    3045 embryo 22-24hr    3019 larva L1    5027 larva L2    3705 larva L3 12hr old    1970 larva L3 puffstage 1-2    2533 larva L3 puffstage 3-6    4820 larva L3 puffstage 7-9    5453 white prepupae new    5533 white prepupae 12hr    5856 white prepupae 24hr    9405 pupae 2d postWPP    4209 pupae 3d postWPP    2210 pupae 4d postWPP    1287 adult male 01day    1389 adult male 05day    2118 adult male 30day    1911 adult female 01day    3943 adult female 05day    5439 adult female 30day    5646 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    10643 embryo 02-04hr    19594 embryo 04-06hr    29163 embryo 06-08hr    35264 embryo 08-10hr    28514 embryo 10-12hr    30150 embryo 12-14hr    16827 embryo 14-16hr    13550 embryo 16-18hr    7720 embryo 18-20hr    4676 embryo 20-22hr    3045 embryo 22-24hr    3019 larva L1    5027 larva L2    3705 larva L3 12hr old    1970 larva L3 puffstage 1-2    2533 larva L3 puffstage 3-6    4820 larva L3 puffstage 7-9    5453 white prepupae new    5533 white prepupae 12hr    5856 white prepupae 24hr    9405 pupae 2d postWPP    4209 pupae 3d postWPP    2210 pupae 4d postWPP    1287 adult male 01day    1389 adult male 05day    2118 adult male 30day    1911 adult female 01day    3943 adult female 05day    5439 adult female 30day    5646 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0002525 expression level Developmental Stage   Expression Level embryo 00-02hr    10643 embryo 02-04hr    19594 embryo 04-06hr    29163 embryo 06-08hr    35264 embryo 08-10hr    28514 embryo 10-12hr    30150 embryo 12-14hr    16827 embryo 14-16hr    13550 embryo 16-18hr    7720 embryo 18-20hr    4676 embryo 20-22hr    3045 embryo 22-24hr    3019 larva L1    5027 larva L2    3705 larva L3 12hr old    1970 larva L3 puffstage 1-2    2533 larva L3 puffstage 3-6    4820 larva L3 puffstage 7-9    5453 white prepupae new    5533 white prepupae 12hr    5856 white prepupae 24hr    9405 pupae 2d postWPP    4209 pupae 3d postWPP    2210 pupae 4d postWPP    1287 adult male 01day    1389 adult male 05day    2118 adult male 30day    1911 adult female 01day    3943 adult female 05day    5439 adult female 30day    5646 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (10643) embryo 02-04hr  (19594) embryo 04-06hr  (29163) embryo 06-08hr  (35264) embryo 08-10hr  (28514) embryo 10-12hr  (30150) embryo 12-14hr  (16827) embryo 14-16hr  (13550) embryo 16-18hr  (7720) embryo 18-20hr  (4676) embryo 20-22hr  (3045) embryo 22-24hr  (3019) larva L1  (5027) larva L2  (3705) larva L3 12hr old  (1970) larva L3 puffstage 1-2  (2533) larva L3 puffstage 3-6  (4820) larva L3 puffstage 7-9  (5453) white prepupae new  (5533) white prepupae 12hr  (5856) white prepupae 24hr  (9405) pupae 2d postWPP  (4209) pupae 3d postWPP  (2210) pupae 4d postWPP  (1287) adult male 01day  (1389) adult male 05day  (2118) adult male 30day  (1911) adult female 01day  (3943) adult female 05day  (5439) adult female 30day  (5646) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (10643) embryo 02-04hr  (19594) embryo 04-06hr  (29163) embryo 06-08hr  (35264) embryo 08-10hr  (28514) embryo 10-12hr  (30150) embryo 12-14hr  (16827) embryo 14-16hr  (13550) embryo 16-18hr  (7720) embryo 18-20hr  (4676) embryo 20-22hr  (3045) embryo 22-24hr  (3019) larva L1  (5027) larva L2  (3705) larva L3 12hr old  1970 larva L3 puffstage 1-2  (2533) larva L3 puffstage 3-6  (4820) larva L3 puffstage 7-9  (5453) white prepupae new  (5533) white prepupae 12hr  (5856) white prepupae 24hr  (9405) pupae 2d postWPP  (4209) pupae 3d postWPP  2210 pupae 4d postWPP    1287 adult male 01day    1389 adult male 05day  2118 adult male 30day  1911 adult female 01day  (3943) adult female 05day  (5439) adult female 30day  (5646) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr  10643 embryo 02-04hr  19594 embryo 04-06hr  (29163) embryo 06-08hr  (35264) embryo 08-10hr  (28514) embryo 10-12hr  (30150) embryo 12-14hr  16827 embryo 14-16hr  13550 embryo 16-18hr    7720 embryo 18-20hr    4676 embryo 20-22hr    3045 embryo 22-24hr    3019 larva L1    5027 larva L2    3705 larva L3 12hr old    1970 larva L3 puffstage 1-2    2533 larva L3 puffstage 3-6    4820 larva L3 puffstage 7-9    5453 white prepupae new    5533 white prepupae 12hr    5856 white prepupae 24hr    9405 pupae 2d postWPP    4209 pupae 3d postWPP    2210 pupae 4d postWPP    1287 adult male 01day    1389 adult male 05day    2118 adult male 30day    1911 adult female 01day    3943 adult female 05day    5439 adult female 30day    5646 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    10643 embryo 02-04hr    19594 embryo 04-06hr    29163 embryo 06-08hr    35264 embryo 08-10hr    28514 embryo 10-12hr    30150 embryo 12-14hr    16827 embryo 14-16hr    13550 embryo 16-18hr    7720 embryo 18-20hr    4676 embryo 20-22hr    3045 embryo 22-24hr    3019 larva L1    5027 larva L2    3705 larva L3 12hr old    1970 larva L3 puffstage 1-2    2533 larva L3 puffstage 3-6    4820 larva L3 puffstage 7-9    5453 white prepupae new    5533 white prepupae 12hr    5856 white prepupae 24hr    9405 pupae 2d postWPP    4209 pupae 3d postWPP    2210 pupae 4d postWPP    1287 adult male 01day    1389 adult male 05day    2118 adult male 30day    1911 adult female 01day    3943 adult female 05day    5439 adult female 30day    5646 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0002525    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0002525 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: larval central nervous system, larval trachea. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, adult central nervous system, adult crop, larval hindgut, adult heart, larval salivary gland, adult female reproductive system, adult male reproductive system, larval carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0002525 expression level Tissue   Expression Level Larval Central Nervous System    1501.8 Larval Midgut    95.3 Larval Hindgut    110.8 Larval Malpighian Tubules    47.5 Larval Fat Body    70.6 Larval Salivary Gland    142.1 Larval Trachea    504.75 Larval Carcass    134 Adult Head    104 Adult Eye    203.375 Adult Brain    269.4 Adult Thoracic-Abdominal Ganglion    218.9 Adult Crop    124.9 Adult Midgut    51.9 Adult Hindgut    48.8 Adult Malpighian Tubules    63.2 Adult Fat Body    68.5 Adult Salivary Gland no informative data Adult Heart    140.125 Adult VirginFemale Spermatheca    85.6 Adult InseminatedFemale Spermatheca    118.8 Adult Ovary    228.5 Adult Testis    222.8 Adult Male Accessory Gland    262.7 Adult Carcass    67.7 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System  (1501.8) Larval Midgut    95.3 Larval Hindgut    110.8 Larval Malpighian Tubules    47.5 Larval Fat Body    70.6 Larval Salivary Gland    142.1 Larval Trachea  504.75 Larval Carcass    134 Adult Head    104 Adult Eye    203.375 Adult Brain    269.4 Adult Thoracic-Abdominal Ganglion    218.9 Adult Crop    124.9 Adult Midgut    51.9 Adult Hindgut    48.8 Adult Malpighian Tubules    63.2 Adult Fat Body    68.5 Adult Salivary Gland no informative data Adult Heart    140.125 Adult VirginFemale Spermatheca    85.6 Adult InseminatedFemale Spermatheca    118.8 Adult Ovary    228.5 Adult Testis    222.8 Adult Male Accessory Gland    262.7 Adult Carcass    67.7 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System  (1501.8) Larval Midgut    95.3 Larval Hindgut    110.8 Larval Malpighian Tubules    47.5 Larval Fat Body    70.6 Larval Salivary Gland    142.1 Larval Trachea    504.75 Larval Carcass    134 Adult Head    104 Adult Eye    203.375 Adult Brain    269.4 Adult Thoracic-Abdominal Ganglion    218.9 Adult Crop    124.9 Adult Midgut    51.9 Adult Hindgut    48.8 Adult Malpighian Tubules    63.2 Adult Fat Body    68.5 Adult Salivary Gland no informative data Adult Heart    140.125 Adult VirginFemale Spermatheca    85.6 Adult InseminatedFemale Spermatheca    118.8 Adult Ovary    228.5 Adult Testis    222.8 Adult Male Accessory Gland    262.7 Adult Carcass    67.7 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    1501.8 Larval Midgut    95.3 Larval Hindgut    110.8 Larval Malpighian Tubules    47.5 Larval Fat Body    70.6 Larval Salivary Gland    142.1 Larval Trachea    504.75 Larval Carcass    134 Adult Head    104 Adult Eye    203.375 Adult Brain    269.4 Adult Thoracic-Abdominal Ganglion    218.9 Adult Crop    124.9 Adult Midgut    51.9 Adult Hindgut    48.8 Adult Malpighian Tubules    63.2 Adult Fat Body    68.5 Adult Salivary Gland no informative data Adult Heart    140.125 Adult VirginFemale Spermatheca    85.6 Adult InseminatedFemale Spermatheca    118.8 Adult Ovary    228.5 Adult Testis    222.8 Adult Male Accessory Gland    262.7 Adult Carcass    67.7 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0002525 expression level Tissue   Expression Level Larval Central Nervous System    1501.8 Larval Midgut    95.3 Larval Hindgut    110.8 Larval Malpighian Tubules    47.5 Larval Fat Body    70.6 Larval Salivary Gland    142.1 Larval Trachea    504.75 Larval Carcass    134 Adult Head    104 Adult Eye    203.375 Adult Brain    269.4 Adult Thoracic-Abdominal Ganglion    218.9 Adult Crop    124.9 Adult Midgut    51.9 Adult Hindgut    48.8 Adult Malpighian Tubules    63.2 Adult Fat Body    68.5 Adult Salivary Gland no informative data Adult Heart    140.125 Adult VirginFemale Spermatheca    85.6 Adult InseminatedFemale Spermatheca    118.8 Adult Ovary    228.5 Adult Testis    222.8 Adult Male Accessory Gland    262.7 Adult Carcass    67.7 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System  (1501.8) Larval Midgut    95.3 Larval Hindgut    110.8 Larval Malpighian Tubules    47.5 Larval Fat Body    70.6 Larval Salivary Gland    142.1 Larval Trachea  504.75 Larval Carcass    134 Adult Head    104 Adult Eye    203.375 Adult Brain    269.4 Adult Thoracic-Abdominal Ganglion    218.9 Adult Crop    124.9 Adult Midgut    51.9 Adult Hindgut    48.8 Adult Malpighian Tubules    63.2 Adult Fat Body    68.5 Adult Salivary Gland no informative data Adult Heart    140.125 Adult VirginFemale Spermatheca    85.6 Adult InseminatedFemale Spermatheca    118.8 Adult Ovary    228.5 Adult Testis    222.8 Adult Male Accessory Gland    262.7 Adult Carcass    67.7 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System  1501.8 Larval Midgut    95.3 Larval Hindgut    110.8 Larval Malpighian Tubules    47.5 Larval Fat Body    70.6 Larval Salivary Gland    142.1 Larval Trachea    504.75 Larval Carcass    134 Adult Head    104 Adult Eye    203.375 Adult Brain    269.4 Adult Thoracic-Abdominal Ganglion    218.9 Adult Crop    124.9 Adult Midgut    51.9 Adult Hindgut    48.8 Adult Malpighian Tubules    63.2 Adult Fat Body    68.5 Adult Salivary Gland no informative data Adult Heart    140.125 Adult VirginFemale Spermatheca    85.6 Adult InseminatedFemale Spermatheca    118.8 Adult Ovary    228.5 Adult Testis    222.8 Adult Male Accessory Gland    262.7 Adult Carcass    67.7 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    1501.8 Larval Midgut    95.3 Larval Hindgut    110.8 Larval Malpighian Tubules    47.5 Larval Fat Body    70.6 Larval Salivary Gland    142.1 Larval Trachea    504.75 Larval Carcass    134 Adult Head    104 Adult Eye    203.375 Adult Brain    269.4 Adult Thoracic-Abdominal Ganglion    218.9 Adult Crop    124.9 Adult Midgut    51.9 Adult Hindgut    48.8 Adult Malpighian Tubules    63.2 Adult Fat Body    68.5 Adult Salivary Gland no informative data Adult Heart    140.125 Adult VirginFemale Spermatheca    85.6 Adult InseminatedFemale Spermatheca    118.8 Adult Ovary    228.5 Adult Testis    222.8 Adult Male Accessory Gland    262.7 Adult Carcass    67.7 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland no informative data Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    104   NA  Eye    203.375   NA  Brain    269.4   1501.8  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    218.9   NA  Crop    124.9   95.3  Midgut    51.9   110.8  Hindgut    48.8   47.5  Malpighian Tubules    63.2   70.6  Fat Body    68.5   142.1  Salivary Gland    no informative data   NA  Heart    140.125   504.75  Trachea    NA   NA  VirginFemale Spermatheca    85.6   NA  InseminatedFemale Spermatheca    118.8   NA  Ovary    228.5   NA  Testis    222.8   NA  Male Accessory Gland    262.7   134  Carcass    67.7 modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_30
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0002525 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG6944-RA FlyExpress - Embryonic expression images (BDGP data) • Show all FlyExpress processed images for Lam Stages(s) 4-6 Stages(s) 7-8 Stages(s) 11-12 Stages(s) 13-16
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal Lam04643 LamCB03749 lethal, with Scer\GAL4C23 LamScer\UAS.cMAa lethal, with Scer\GAL4da.G32 LamScer\UAS.cMAa lethal, with Scer\GAL4how-24B LamScer\UAS.cMAa lethal | larval stage LamP lethal | partially | recessive LamP lethal | pharate adult stage Lam9 Lam14 lethal | pharate adult stage (with Df(2L)GpdhA) Lam14 lethal | pupal stage Lam9 Lam14 lethal | pupal stage (with Df(2L)GpdhA) Lam14 lethal | recessive Lam2 Lam25A Lam02459 Lam04643 Lamex91 Lamex98 lethal | recessive | third instar larval stage Lam04643 lethal | temperature conditional, with Scer\GAL4arm.PS LamScer\UAS.cMAa semi-lethal LamP semi-lethal | larval stage Lam04643 LamD395 LamG262 semi-lethal | larval stage (with Df(2L)cl-h1) LamD395 semi-lethal | pupal stage Lam04643 LamD395 LamG262 LamP semi-lethal | pupal stage (with Df(2L)cl-h1) LamD395 semi-lethal | pupal stage (with Lam14) LamP semi-lethal | pupal stage (with LamP) Lam14 semi-viable (with Df(2L)cl-h4) Lam83 LamA25 LamAri3 LamAri7 LamK2 semi-viable | recessive Lam83 LamAri3 LamAri7 LamK2 viable LamA25 LamEY08333 viable, with Scer\GAL4He.PZ LamScer\UAS.cMAa viable, with Scer\GAL4nrv2.PS LamScer\UAS.cMAa viable, with Scer\GAL4pnr-MD237 LamGD1478 viable | temperature conditional, with Scer\GAL4arm.PS LamScer\UAS.cMAa Sterility Allele female sterile | recessive LamP fertile LamEY08333 male sterile | recessive LamP sterile LamP sterile (with Lam14) LamP sterile (with LamP) Lam14 sterile | female | germline clone | recessive Lamunspecified Other Phenotypes Allele cell growth defective Lam14 developmental rate defective Lam9 Lam14 developmental rate defective (with Df(2L)GpdhA) Lamsz18 flight defective LamP flightless | recessive LamP gravitaxis behavior defective | larval stage Lam04643 LamD395 LamG262 LamP locomotor behavior defective Lam14 LamP locomotor behavior defective (with Df(2L)GpdhA) Lam14 locomotor behavior defective (with Lam14) LamP locomotor behavior defective (with LamP) Lam14 locomotor behavior defective | larval stage Lam04643 LamD395 LamG262 LamP locomotor behavior defective | recessive LamP uncoordinated | recessive LamP visible, with Scer\GAL4pnr-MD237 LamGD1478 visible | adult stage LamA25 visible | adult stage (with Df(2L)cl-h4) LamA25 wild-type Lam+t4.2 Lam+tLa Phenotype manifest in Allele adult cuticle | pharate adult stage Lam14 adult midgut | pharate adult stage Lam14 Lam9 annulate lamellae LamP chaeta, with Scer\GAL4pnr-MD237 LamGD1478 cystocyte & nucleus & pharate adult Lam14 dorsal appendage | germline clone Lam02459 Lam04643 Lama7 dorsal appendage | germline clone | supernumerary Lam02459 Lam04643 Lama7 dorsal branch primordium Lam04643 egg | germline clone Lam02459 Lam04643 Lama7 Lamex98 Lamsz18 egg chamber | germline clone Lam04643 Lama7 Lamex98 Lamsz18 Lamunspecified egg chamber | pharate adult stage Lam14 eye Lam83 LamAri3 LamAri7 LamK2 eye (with Df(2L)cl-h4) LamA25 LamAri3 eye & nucleus & pharate adult Lam14 Lam9 eye disc & nucleus | ectopic LamAri3 eye disc & nucleus | ectopic (with Df(2L)cl-h4) LamA25 LamAri3 eye disc & nucleus | ectopic | somatic clone Lam04643 gamete | female | germline clone Lamunspecified ganglionic branch primordium Lam04643 Lamex91 gonad | male & pharate adult Lam14 longitudinal muscle | pharate adult stage Lam14 nuclear inner membrane LamdsRNA.cWa nuclear membrane LamP LamdsRNA.cWa nuclear membrane | pharate adult stage Lam14 Lam9 nuclear outer membrane LamdsRNA.cWa nuclear pore LamP LamdsRNA.cWa nucleus & eye photoreceptor cell & eye disc Lam04643 nurse cell | germline clone Lam04643 Lama7 ommatidium LamA25 oocyte LamP oocyte | germline clone Lam04643 Lama7 ovariole LamP ovary LamP ovary | pharate adult stage Lam14 pigment cell | pharate adult stage Lam14 presumptive embryonic/larval muscle system Lam04643 LamG262 presumptive embryonic/larval tracheal system Lam02459 Lam04643 Lama7 Lamex91 Lamex98 Lamsz18 Lamsz9 rhabdomere LamAri3 rhabdomere (with Df(2L)cl-h4) LamA25 LamAri3 spermatozoon LamP subesophageal ganglion | pharate adult stage Lam14 trichogen cell, with Scer\GAL4pnr-MD237 LamGD1478
Classical Alleles ( 22 )
For All Classical Alleles Show
Allele of Lam Class Mutagen Stocks Known lesion Lam04643 loss of function allele P-element activity 1 Yes LamA25 loss of function allele X ray 1 Yes LamEY08333 P-element activity 1 -- LamK2 loss of function allele X ray 1 Yes Lamsz18 ethyl methanesulfonate 1 -- Lam14 amorphic allele - genetic evidence P-element activity 0 Yes Lam9 amorphic allele - genetic evidence P-element activity 0 Yes Lam02459 P-element activity 0 Yes Lam25A ethyl methanesulfonate 0 -- Lam2 ethyl methanesulfonate 0 -- Lam83 loss of function allele X ray 0 Yes Lama7 ethyl methanesulfonate 0 -- LamAri3 loss of function allele ethyl methanesulfonate 0 Yes LamAri7 loss of function allele ethyl methanesulfonate 0 Yes LamCB03749 P-element activity 0 Yes LamD395 P-element activity 0 Yes Lamex91 P-element activity 0 Yes Lamex98 P-element activity 0 Yes LamG262 P-element activity 0 Yes LamP Delta2-3 0 Yes Lamsz9 ethyl methanesulfonate 0 -- Lamunspecified 0 --
Alleles Carried on Transgenic Constructs ( 14 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Lam Class Mutagen Stocks Known lesion LamScer\UAS.T:Avic\GFP in vitro construct - regulatory fusion in vitro construct - coding region fusion 4 Yes LamGD1478 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes LamScer\UAS.Scer\FRT.stop.Scer\FRT-m.71.T:Ivir\HA1,T:Avic\GFP-EGFP,T:Mmus\pm,T:Avic\GFP-mCitrine,T:Disc\RFP-mCherry,T:Avic\GFP-ECFP.Cer,T:SV5\V5 in vitro construct - regulatory fusion in vitro construct - coding region fusion 2 Yes LamJF01389 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes LamKK102399 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Lam+t4.2 in vitro construct - genomic fragment 0 Yes Lam+tLa in vitro construct - genomic fragment 0 Yes LamdsRNA.cBa in vitro construct - RNAi 0 -- LamdsRNA.cSa in vitro construct - RNAi 0 Yes LamdsRNA.cWa in vitro construct - RNAi 0 Yes Lamhs.PS in vitro construct - regulatory fusion 0 Yes Lamhs.T:Ecol\lacI in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes LamScer\UAS.cGa in vitro construct - regulatory fusion 0 Yes LamScer\UAS.cMAa in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(2L)BSC169 (Christensen and Cook, 2006.7.11) Df(2L)cl1 (Kotarski et al., 1983, Szidonya and Reuter, 1988, Szidonya and Reuter, 1988, BDGP Project Members, 1994-1999) Df(2L)cl2 (Kotarski et al., 1983, Szidonya and Reuter, 1988, Szidonya and Reuter, 1988) Df(2L)cl7 (Kotarski et al., 1983, Szidonya and Reuter, 1988, Szidonya and Reuter, 1988, BDGP Project Members, 1994-1999) Df(2L)cl-h1 (Szidonya and Reuter, 1988, Szidonya and Reuter, 1988, Eberl et al., 1997) Df(2L)cl-h2 (Szidonya and Reuter, 1988, Szidonya and Reuter, 1988, Eberl et al., 1997) Df(2L)cl-h3 (Guillemin et al., 2001, Szidonya and Reuter, 1988, Szidonya and Reuter, 1988) Df(2L)cl-h4 (Patterson et al., 2004, Szidonya and Reuter, 1988, Szidonya and Reuter, 1988, Eberl et al., 1997) Df(2L)Exel6012 (Ryder, 2004.4.26) Df(2L)Exel7023 (Ryder, 2004.4.26) Df(2L)GpdhA (Spradling et al., 1999, Guillemin et al., 2001, Osouda et al., 2005, Kotarski et al., 1983, BDGP Project Members, 1994-1999, Guillemin, 1997.6.19) Df(2L)PM101 (BDGP Project Members, 1994-1999) Df(2L)sc19-4 (Szidonya and Reuter, 1988, Szidonya and Reuter, 1988) Df(2L)sc19-12 (Szidonya and Reuter, 1988, Szidonya and Reuter, 1988) Ts(YSt;2Lt)B236+Ts(YSt;2Rt)H164 (Kotarski et al., 1983)
Not disrupted in	Df(2L)2802 (Kotarski et al., 1983) Df(2L)E110 (Spradling et al., 1999, BDGP Project Members, 1994-1999) Df(2L)Gpdh75 (Kotarski et al., 1983) Df(2L)Gpdh78 (Kotarski et al., 1983) Df(2L)sc19-1 (Szidonya and Reuter, 1988, Szidonya and Reuter, 1988) Df(2L)sc19-5 (Szidonya and Reuter, 1988, Szidonya and Reuter, 1988) Df(2L)sc19-6 (Szidonya and Reuter, 1988, Szidonya and Reuter, 1988) Df(2L)sc19-7 (Szidonya and Reuter, 1988, Szidonya and Reuter, 1988) Df(2L)sc19-8 (Szidonya and Reuter, 1988, Szidonya and Reuter, 1988) Df(2L)tkv2 (Spradling et al., 1999, Szidonya and Reuter, 1988, Szidonya and Reuter, 1988, BDGP Project Members, 1994-1999) Df(2L)tkv3 (Szidonya and Reuter, 1988, Szidonya and Reuter, 1988, BDGP Project Members, 1994-1999)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD1478} NA P{KK102399} NA P{TRiP.JF01389} NA P{UAS-Flybow.2.0} NA P{UAS-Lam.G} NA P{UAS-Lam.GFP} NA P{UAS-Lam.MA} NA heat-shock construct P{hs-LacI-Lam} NA P{hs-Lam.Sb} NA characterization construct P{Lam+4.2} NA P{Lam+.L} NA
Insertions
	Type of insertions Name Expression data insertion of enhancer trap P{lacW}Hel25Ek11511 No P{lacW}l(2)SH0454SH0454 No P{lacW}LamP No P{PZ}Lam02459 No P{PZ}Lam04643 No insertion of mobile activating element P{EPgy2}LamEY08333 NA miscellaneous insertions P{PTT-GB}LamCB03749 NA P{PTT-GB}LamG262 NA
Gene Ontology: Function, Process & Cellular Component ( 22 unique terms )
Terms Based on Experimental Evidence ( 20 terms )
Molecular Function
CV term Evidence References
protein binding inferred from physical interaction with Ote AND inferred from physical interaction with fs(1)Ya (Goldberg et al., 1998)
Biological Process
CV term Evidence References
central nervous system development inferred from mutant phenotype (Osouda et al., 2005) centrosome organization inferred from mutant phenotype (Müller et al., 2010) chitin-based cuticle development inferred from mutant phenotype (Osouda et al., 2005) chromatin silencing inferred from mutant phenotype (Shevelyov et al., 2009) compound eye morphogenesis inferred from mutant phenotype (Osouda et al., 2005) digestive tract morphogenesis inferred from mutant phenotype (Osouda et al., 2005) gonad morphogenesis inferred from mutant phenotype (Osouda et al., 2005) lateral inhibition inferred from mutant phenotype (Mummery-Widmer et al., 2009) mitotic nuclear envelope reassembly inferred from direct assay (Ulitzur et al., 1992) nuclear envelope organization inferred from mutant phenotype (Osouda et al., 2005) nuclear migration inferred from mutant phenotype (Patterson et al., 2004) terminal branching, open tracheal system inferred from mutant phenotype (Guillemin and Krasnow, 1995, Guillemin et al., 2001)
Cellular Component
CV term Evidence References
centrosome inferred from direct assay (Müller et al., 2010) lipid particle inferred from direct assay (Cermelli et al., 2006) microtubule associated complex inferred from direct assay (Hughes et al., 2008) mitotic spindle inferred from direct assay (Müller et al., 2010) nuclear envelope inferred from direct assay (Pilot et al., 2006, Schulze et al., 2009) nuclear lamina inferred from direct assay (Shevelyov et al., 2009, Riemer et al., 1995) nucleus inferred from direct assay (Furukawa et al., 2003)
Terms Based on Predictions or Assertions ( 3 terms )
Molecular Function
CV term Evidence References
structural molecule activity inferred from electronic annotation with InterPro:IPR001664 (FlyBase Curators et al., 2004-)
Biological Process
CV term Evidence References
mitotic nuclear envelope reassembly inferred from sequence or structural similarity with EMBL:D50080 (FlyBase, 1992-)
Cellular Component
CV term Evidence References
lamin filament inferred from sequence or structural similarity with EMBL:D50080 (FlyBase, 1992-) non-traceable author statement (Swiss-Prot Project Members, 1988.11.1) traceable author statement (Smith and Fisher, 1989)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Lam allele Gene References Lam83 klar (Patterson et al., 2004) LamA25 klar (Patterson et al., 2004) LamAri3 klar (Patterson et al., 2004) LamAri7 klar (Patterson et al., 2004) LamK2 klar (Patterson et al., 2004) unspecified EcR (Osouda et al., 2005)
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 59950 DroID - A comprehensive database of gene and protein interactions. • FBgn0002525 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 33782
Orthologs
Genome-wide drosophilid orthologs	Dana\GF15147 Dere\GG25079 Dgri\GH10295 Dmoj\GI17991 Dpse\Lam Dsec\GM18554 Dvir\GJ19583 Dwil\GK21105 Dyak\GE25472
Curated drosophilid orthologs	Dafs\Lam (Bartolome, 2005) Dmir\Lam (Bartolome, 2005) Dpse\Lam (Bartolome, 2005)
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL003415-PA Aedes aegypti (mosquito) AGAP011938-PA Anopheles gambiae (mosquito) XP_396670.2 Apis mellifera (honey bee) XP_001943032.1 Acyrthosiphon pisum (pea aphid) 121709 Branchiostoma floridae (lancelet) ENSBTAP00000018110 Bos taurus (bovine) ENSCAFP00000024801 Canis familiaris (dog) ENSCINP00000001638 Ciona intestinalis (sea squirt) JA18518 Caenorhabditis japonica (nematode) CPIJ010129 Culex pipens (mosquito) ENSCPOP00000008443 Cavia porcellus (guinea pig) ENSCSAVP00000012034 Ciona savignyi (sedentary tunicate) 309175 Daphnia pulex (daphnia) ENSDARP00000004139 Danio rerio (zebra fish) ENSECAP00000009322 Equus caballus (horse) ENSGACP00000017571 Gymnopilus aculeatus (mushroom) ENSGACP00000024278 Gymnopilus aculeatus (mushroom) ENSGALP00000034565 Gallus gallus (chicken) 113696 Hypsipyla robusta (cedar shoot borer) ENSP00000261366 Homo sapiens (human) ISCW000339-PA Ixodes scapularis (deer tick) 179001 Lottia gigantea (owl limpet) ENSMODP00000005942 Monodelphis domestica (gray opossum) ENSMMUP00000001116 Macaca mulatta (rhesus monkey) ENSMUSP00000025486 Mus musculus (house mouse) 170348 Nematostella vectensis (starlet anemone) XP_001605883.1 Nasonia vitripennis (wasp) ENSOANP00000015881 Ornithorynchus anatinus (platypus) ENSORLP00000011266 Oryzias latipes (japanese killifish) PHUM004764-PA Pediculus humanus (human body louse) PP03008 Pristionchus pacificus (nematode) PP27066 Pristionchus pacificus (nematode) ENSPPYP00000017590 Pongo pygmaeus (orangutan) 139762 Phytophthora sojae (root rot pathogen) ENSPTRP00000029399 Pan troglodytes (chimpanzee) ENSRNOP00000019351 Rattus norvegicus (norway rat) Smp_170930 Schistosoma mansoni (trematode parasite) NP_999665.1 Strongylocentrotus purpuratus (purple sea urchin) 63507 Trichoplax adhaerens (metazoa) XP_972795.1 Tribolium castaneum (red flour beetle) ENSTNIP00000007119 Tetraodon nigroviridis (green spotted pufferfish) 7600 Thalassiosira pseudonana (marine diatom) ENSTRUP00000019489 Takifugu rubripes (pufferfish Takifugu) ENSXETP00000003751 Xenopus tropicalis (frog) ENSXETP00000011292 Xenopus tropicalis (frog) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • NV11973 LH21895 ISCW000339 FBgn0242540 FBgn0068132 FBgn0223097 FBgn0217739 FBgn0208861 FBgn0206725 FBgn0196960 FBgn0175088 FBgn0173461 JGI_V11_309175 FBgn0243572 FBgn0070145 FBgn0163436 FBgn0148251 FBgn0141463 FBgn0140731 FBgn0010397 FBgn0128582 FBgn0117776 FBgn0117208 FBgn0114590 FBgn0092172 FBgn0088680 CPIJ010129 BGIBMGA003652 ACYPI33513 ACYPI007590 ACYPI001798 GB16792 AGAP011938 AAEL003415 PB21893 PHUM039180 GLEAN_15134
Stocks & Reagents
Stocks Listed in FlyBase ( 15 )
Bloomington	35540 w*; P{UAS-Flybow.2.0}VIE-49B 35539 w*; P{UAS-Flybow.2.0}VIE-260B 7375 P{UAS-Lam.GFP}1-9, y1 w* 7376 y1 w*; P{UAS-Lam.GFP}3-3 7378 y1 w*; P{UAS-Lam.GFP}2-1 25093 LamK2 pr1/CyO; st1 31605 y1 v1; P{TRiP.JF01389}attP2 7377 y1 w*; P{UAS-Lam.GFP}3-2/CyO 25092 LamA25 pr1/CyO; st1
VDRC	v107419 P{KK102399}VIE-260B v45636 w1118 P{GD1478}v45636 v45635 w1118; P{GD1478}v45635/TM3
	More stocks available...
Genomic Clones ( 2 )
	BACR35L07 BACR44J04 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 105 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	LD38055
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	AT21078 GH14078 GM08955 GM23954 LD07383 LD08567 LD10531 LD11568 LD14549 LD16784 LD19242 LD19279 LD26145 LD27820 LD29577 LD41164 LD46046 LD46077 LD46390 LP01355 LP23531 RE01506 RE11553 RE17206 RE23341 RE25255 RE33518 RE41650 RE56185 RE57656 SD01608 SD02953 SD04410 SD07013 SD07812 SD09087 SD09310 SD10317 SD23142 SD26958
Other clones	bs58f06 Dmel_neb_009444_0599_2343 EK022314 EK048044 EK050033 EK057455 EK071202 EK083819 EK101628 EK102049 EK107359 EK113622 EK115307 EK121759 EK122951 EK130309 EK151319 EK161751 EK168317 EK171113 EK183044 EK190432 EK198412 EK200003 EK202638 EK219658 EK222850 EK225838 EK247637 EK254464 EK261718 EK268461 EK275520 EK277459 EK277501 EK292802 EK293646 EK293933 EK296309 EK307522 EN10211 FGM207F02 RP003031425 RP003079167 RP003138844 RP003181675 RP003209896 RP003218607 RP003280335 RP003290628 RP003326627 RP003328521 RP003355277 RP003375932 RP003400673 RP003471611 RP003490951 RP003494643 RP003495646 RP003526194 RP003536865 RP003623141 RP003657351 RP003663022
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0002525 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 33782
Antibody Information
	monoclonal antibody (Arama et al., 2003) polyclonal (Wagner et al., 2004)
Other Information
Discoverer
Etymology
	The gene is named "misguided" because terminal branches of the tracheal system do not follow the normal patterns of projection during branch outgrowth in mutants. (Guillemin et al., 2001)
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: Lam CG6944 (Skupski, 1999.11)
Source for database merge of	Source for merge of: Lam l(2)04643 (Spradling et al., 1999) Source for merge of: Lam misguided l(2)25Ec (Guillemin et al., 2001) Source for merge of: misguided l(2)25Ec (Guillemin, 2001.11.15)
Additional comments
Other Comments
	DNA-protein interactions: genome-wide binding profile assayed for Lam protein in Kc167 cells; see Chromatin_types_NKI collection report. Individual protein-binding experiments listed under "Samples" at GEO_GSE22069 (http://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE22069). (Filion et al., 2010) RNAi generated by PCR using primers directed to this gene causes a cell growth and viability phenotype when assayed in Kc167 and S2R+ cells. (Boutros et al., 2004) Lam is required for nuclear attachment to the microtubule organizing centre and for localization of klar to the nuclear envelope. (Patterson et al., 2004) FlyBase curator comment: FBrf0161468 is an erratum for FBrf0151816, which has been retracted, see Struhl, 2004, Cell 116(3): 481. (Chan and Struhl, 2003) Mutations in Lam disrupt the directed outgrowth of the cytoplasmic extensions from terminal cells of the tracheal system. Female germline mutant clones disrupt the dorsal-ventral polarity of the oocyte. (Guillemin et al., 2001) Lam protein interacts with both Ote and fs(1)Ya in a yeast two-hybrid system. (Goldberg et al., 1998) Identification: Enhancer trap expression pattern survey for loci expressed in the ring gland. (Harvie et al., 1998) Biochemical techniques reveal that in living cells lamins are closely associated with both DNA and RNA. (Rzepecki et al., 1998) The Lam gene product is essential for the structural integrity of the nuclear envelope and for the correct integration of nuclear pore complexes into the nuclear membrane. (Lenz-Bohme et al., 1997) Recruitment of fs(1)Ya and Lam to the male pronucleus occurs prior to or during the early stages of pronuclear migration and this accompanies or requires reorganisation of the sperm nucleus. (Liu et al., 1997) Region of a DNA fragment, λ20p1.4, which is a moderately repetitive sequence of the genome present in about 120 copies per haploid genome, polymerises with purified Lam. (Bogachev et al., 1996) The alpha-helical rod domain of Lam is sufficient for the specific interaction with the M/SAR fragment of ftz. For this specific interaction to occur it is essential that Lam is organised above the level of the dimer. (Zhao et al., 1996) Identified as being specifically expressed in the terminal cells of the developing tracheal system and required for the formation and outgrowth of the terminal branches. (Guillemin and Krasnow, 1995) Monoclonal antibody ADL84 is specific for Lam Dm1 and does not bind Lam Dm2. The antibody demonstrates that isolated interphase Lams Dm1 and Dm2 occur as mixed dimers, indicating random interactions. Mapping of the epitope for ADL84 shows Lam Dm2-specific phosphorylation takes place in the amino terminal head domain, most likely at Ser25. (Stuurman et al., 1995) Nuclear assembly has been followed in a cell free system: the Lam gene product plays essential role in nuclear envelope assembly. (Ulitzur et al., 1992) Three isoforms of Lam protein have been purified and their activity in vitro has been studied. (Lin and Fisher, 1990) Lam has been cloned and sequenced. (Osman et al., 1990) Some Lam protein is apparently retained in an envelope-like structure throughout mitosis in early Drosophila embryos. (Harel et al., 1989) A soluble isoform of Lam protein has been identified in the extracts of cultured cells blocked in mitosis. This isoform is the only species detectable in late-stage egg chambers and early embryos. The conversion of nuclear isoforms of Lam protein to this soluble isoform is mediated by a specific rearrangement of phosphate groups rather than large net changes in the levels of Lam protein phosphorylation. The residues involved in the phosphorylation/dephosphorylation reactions have been tentatively mapped within the fragment containing amino acids 385-547. (Smith and Fisher, 1989) l(2)25Ec was included as part of a study of the 24D4--25F2 region. (Szidonya and Reuter, 1988) Gene identified by screening a lambda-gt11 cDNA expression library, constructed from early embryonic mRNA, with monoclonal antibodies against Drosophila lamin. The structural gene for nuclear lamin. Translated as a prolamin of apparent molecular mass of 76kD, which is quickly processed to a 74kD species, presumably by proteolysis. The processed polypeptide is assembled into the nuclear envelope, where it becomes phosphorylated and again attains a mass of 76kD (Smith, Gruenbaum, Berrios, and Fisher, 1987).
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_057268 RefSeq (Proteins) • NP_476616 DDBJ / EMBL / GenBank • AA391522 AA439869 AAF52262 AAN71261 AC009910 AI518515 AQ025968 AQ034028 AX664513 BT001506 CAA30259 CAA34351 CAD80036 CL526005 CS133217 G00464 X07278 X16275 Entrez Gene - A searchable database of RefSeq genes. • 33782 UniProtKB/Swiss-Prot • P08928
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Intermediate filament, C-terminal (IPR001322) Intermediate filament protein (IPR001664) Filament (IPR016044)
Linkouts
	BioGRID - A database of protein and genetic interactions • 59950 DroID - A comprehensive database of gene and protein interactions. • FBgn0002525 DRSC - Results from RNAi screens. • FBgn0002525 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0002525 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG6944-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0002525 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 33782 InParanoid A subset of ortholog calls from InParanoid. • AAEL003415-PA Aedes aegypti (mosquito) AGAP011938-PA Anopheles gambiae (mosquito) XP_396670.2 Apis mellifera (honey bee) XP_001943032.1 Acyrthosiphon pisum (pea aphid) 121709 Branchiostoma floridae (lancelet) ENSBTAP00000018110 Bos taurus (bovine) ENSCAFP00000024801 Canis familiaris (dog) ENSCINP00000001638 Ciona intestinalis (sea squirt) JA18518 Caenorhabditis japonica (nematode) CPIJ010129 Culex pipens (mosquito) ENSCPOP00000008443 Cavia porcellus (guinea pig) ENSCSAVP00000012034 Ciona savignyi (sedentary tunicate) 309175 Daphnia pulex (daphnia) ENSDARP00000004139 Danio rerio (zebra fish) ENSECAP00000009322 Equus caballus (horse) ENSGACP00000017571 Gymnopilus aculeatus (mushroom) ENSGACP00000024278 Gymnopilus aculeatus (mushroom) ENSGALP00000034565 Gallus gallus (chicken) 113696 Hypsipyla robusta (cedar shoot borer) ENSP00000261366 Homo sapiens (human) ISCW000339-PA Ixodes scapularis (deer tick) 179001 Lottia gigantea (owl limpet) ENSMODP00000005942 Monodelphis domestica (gray opossum) ENSMMUP00000001116 Macaca mulatta (rhesus monkey) ENSMUSP00000025486 Mus musculus (house mouse) 170348 Nematostella vectensis (starlet anemone) XP_001605883.1 Nasonia vitripennis (wasp) ENSOANP00000015881 Ornithorynchus anatinus (platypus) ENSORLP00000011266 Oryzias latipes (japanese killifish) PHUM004764-PA Pediculus humanus (human body louse) PP03008 Pristionchus pacificus (nematode) PP27066 Pristionchus pacificus (nematode) ENSPPYP00000017590 Pongo pygmaeus (orangutan) 139762 Phytophthora sojae (root rot pathogen) ENSPTRP00000029399 Pan troglodytes (chimpanzee) ENSRNOP00000019351 Rattus norvegicus (norway rat) Smp_170930 Schistosoma mansoni (trematode parasite) NP_999665.1 Strongylocentrotus purpuratus (purple sea urchin) 63507 Trichoplax adhaerens (metazoa) XP_972795.1 Tribolium castaneum (red flour beetle) ENSTNIP00000007119 Tetraodon nigroviridis (green spotted pufferfish) 7600 Thalassiosira pseudonana (marine diatom) ENSTRUP00000019489 Takifugu rubripes (pufferfish Takifugu) ENSXETP00000003751 Xenopus tropicalis (frog) ENSXETP00000011292 Xenopus tropicalis (frog) Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution • /polycomb/lamin1.htm InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 33782 modMine - Data generated by the modENCODE project. • FBgn0002525 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • NV11973 LH21895 ISCW000339 FBgn0242540 FBgn0068132 FBgn0223097 FBgn0217739 FBgn0208861 FBgn0206725 FBgn0196960 FBgn0175088 FBgn0173461 JGI_V11_309175 FBgn0243572 FBgn0070145 FBgn0163436 FBgn0148251 FBgn0141463 FBgn0140731 FBgn0010397 FBgn0128582 FBgn0117776 FBgn0117208 FBgn0114590 FBgn0092172 FBgn0088680 CPIJ010129 BGIBMGA003652 ACYPI33513 ACYPI007590 ACYPI001798 GB16792 AGAP011938 AAEL003415 PB21893 PHUM039180 GLEAN_15134
Synonyms & Secondary IDs ( 63 )
Reported As
Symbol Synonym	74/76 (Filson et al., 1985) 2459 (Harvie et al., 1998) CG6944 (Cermelli et al., 2006, Stuart et al., 2007, Quinones-Coello, 2007, Keleman et al., 2009.8.5, Hughes et al., 2008, Ni et al., 2008, Cammarato et al., 2011) D5 (Stuurman et al., 1999) Dm (Ulitzur et al., 1997) Dm0 (Goldstein and Gunawardena, 2000, de Saint Phalle et al., 1999, Stuurman, 1994.1.13, Berrios and Fisher, 1998, de Saint Phalle et al., 1999, Brandt et al., 2006, Pindyurin et al., 2007, Brandt, 2006, Pickersgill et al., 2006) Dm1 (Berrios and Fisher, 1998) Dm2 (Berrios and Fisher, 1998) Dm(0) (Marshall, 2003) Dm0 (Schulze et al., 2005, Wolfner and Wilson, 2001, Loppin et al., 2001, Royzman et al., 2002, Loppin et al., 2001, Rzepecki and Fisher, 2000, Stuurman et al., 1999, Goldberg et al., 1999, Stuurman et al., 1999, Krohne et al., 1998, Rzepecki et al., 1998, Sasse et al., 1997, Ashery-Padan et al., 1997, Lenz-Bohme et al., 1997, Stuurman, 1997) Dm1 (Rzepecki and Fisher, 2000, Rzepecki et al., 1998, Ulitzur et al., 1997, Lin and Fisher, 1990, Smith and Fisher, 1989) Dm2 (Rzepecki and Fisher, 2000, Ulitzur et al., 1997, Lin and Fisher, 1990, Smith and Fisher, 1989) Dmmit (Rzepecki and Fisher, 2000, Lin and Fisher, 1990, Smith and Fisher, 1989) DMO (Stuurman et al., 1996) Dmo (Georgatos et al., 1994) DmLamin (Shareef et al., 2001) DmO (Mills et al., 2006, Kumar and Doumanis, 2000, Fraser et al., 1997, Wagner et al., 2004, Polychronidou et al., 2010) Dmo (Klapper et al., 1997) jf27 (Eberl et al., 1997, Szidonya and Reuter, 1988, Szidonya and Reuter, 1988) l(2)25Ec   l(2)04643 (Gildea et al., 2000, Meister and Braun, 1995.10, BDGP Project Members, 1994-1999, ) l(2)gdh-7 (Kotarski et al., 1983, ) l(2)gdh7   l(2)jf27   lam (Wilk et al., 2004, Maroni, 1994, Munoz-Alarcon et al., 2006, Cermelli et al., 2006, Muñoz-Alarcón et al., 2007, Pavlovic et al., 2008) Lam (Christensen and Cook, 2006.7.11, Schneider et al., 2006, Kracklauer et al., 2007, Stuart et al., 2007, Buszczak et al., 2007, Quinones-Coello, 2007, Bao et al., 2005, Pindyurin et al., 2007, Shevelyov et al., 2009, Bao et al., 2007, Pickersgill et al., 2006, Mummery-Widmer et al., 2009, de Wit et al., 2008, Wagner et al., 2010, Müller et al., 2010) LAM (van Steensel et al., 2010, Filion et al., 2010, van Bemmel et al., 2010) Lam(Dm0) (Kracklauer et al., 2007) LamDm0 (Starr and Fischer, 2005) lamDm0 (Fischer et al., 2003) lamDm0 (Osouda et al., 2005, Muñoz-Alarcón et al., 2007) Lam Dm0 (Patterson et al., 2004) LamDm0 (Shevelyov et al., 2009, Furukawa et al., 2003) lamin (Doheny et al., 2008) Lamin (Lancaster et al., 2010) lamin Dm0 (Wagner et al., 2004) lamin Dm0 (Cohen et al., 2001, Arama et al., 2003, Deng and Lin, 2001, Jackson et al., 2002, de Saint Phalle et al., 2002, Barkett et al., 2002, Loppin et al., 2000, Guillemin et al., 1998, Stuurman et al., 1995, Riemer et al., 1995, ) Lamin Dm0 (Reim et al., 1999) misg (Anonymous, 2001, Guillemin et al., 2001) nlam (Eberl et al., 1997)
Name Synonym	B-type Lamin (Starr and Fischer, 2005) B-type lamin (Pindyurin et al., 2007) intermediate filament-like lamina (Heun et al., 2001) Lamin (Capelson and Corces, 2005, Pilot et al., 2006, Benchabane et al., 2011, Lancaster et al., 2007, Staudt et al., 2006, Kind and Akhtar, 2007, Peretz et al., 2007, Franklin-Dumont et al., 2007, Kurshakova et al., 2007, Cinnamon et al., 2008, Meignin and Davis, 2008, Minakhina et al., 2005, Rollins et al., 2004, Bao et al., 2007, Stern et al., 2009, Vilmos et al., 2009, Pickersgill et al., 2006, Gawlinski et al., 2007, Sabri et al., 2007, van Steensel et al., 2010, Siegrist et al., 2010, Manak et al., 2007, Taniue et al., 2010, Wang et al., 2010, Bulchand et al., 2010, Gerbasi et al., 2010, Chen et al., 2011, Chang et al., 2011, McPhee et al., 2010, Cammarato et al., 2011) lamin (Mills et al., 2006, Hutchison et al., 2001, Fisher et al., 2001, Lee et al., 2000, Saunders and Cohen, 1999, Gigliotti et al., 1998, Likhacheva et al., 1998, Goldberg et al., 1998, Rzepecki et al., 1998, Lenz et al., 1995, Harel et al., 1989, Smith and Fisher, 1989, Wilson, 2005, Cermelli et al., 2006, McHugh et al., 2004, Crevel et al., 2005, Peterson et al., 2007, Berry and Baehrecke, 2007, Yapici et al., 2008, Maruyama et al., 2011, Barry et al., 2011, Oliver, 2008, Kirchner et al., 2008, Daish et al., 2004, Muraro and Moffat, 2006, Xylourgidis et al., 2006, Häsemeyer et al., 2009, Desai et al., 2009, Gawlinski et al., 2007, Hadjieconomou et al., 2011, Lanson et al., 2011, Wagner et al., 2004) lamin A (Prokopenko et al., 1999) lamin B (Brandt et al., 2006, Pathak et al., 2007, Lince-Faria et al., 2009, Wang et al., 2011) Lamin B (Kalverda et al., 2010) Lamin-B (Civelekoglu-Scholey et al., 2010) Lamin D (Vrailas and Moses, 2006) lamin D0 (Karsten et al., 2006) lamin Dm0 (Graham et al., 2006) Lamin Do (Bosveld et al., 2008) LaminDm (Chang et al., 2011) lamin Dm0 (Prokopenko et al., 1999, Schulze et al., 2006, McHugh et al., 2004, Sharakhov et al., 2008, Prufert et al., 2004) Lamin Dm0 (Smith et al., 2004, Martin and Baehrecke, 2004, Pinto et al., 2006) LaminDm0 (Urwyler et al., 2007) lamin Dm[[0]] (Bao et al., 2006) Lamin Dm0 (. Tanner et al., 2007, Schulze et al., 2008, Paige Bass et al., 2007, Schulze et al., 2009, Dialynas et al., 2010) lamin Dm0 (Melcer and Gruenbaum, 2006, Mani et al., 2003, Bao et al., 2005, Mattout et al., 2007, Pinto et al., 2008, Furukawa et al., 2009) Lamin Dmo (Kessler and Müller, 2009, Zimek and Weber, 2011) Lamin DmO (Creagh et al., 2009) lethal(2)25Ec   misguided (Guillemin, 1995, Anonymous, 2001, Guillemin et al., 2001, ) misrouted (Guillemin and Krasnow, 1995, ) n-lamin (Petersen et al., 1997) nuclear lamin (Fischer et al., 2003, Baehrecke, 2003, Xu et al., 2004, Martin et al., 2007) α-Lamin (Uv et al., 2000)
Secondary FlyBase IDs
	FBgn0001930 FBgn0010582 FBgn0014344
References ( 295 )
Generate a list of	All references relating to this gene ( 295 )
List References by type	Research paper  ( 211 ) Supplementary material  ( 14 ) Review  ( 17 ) Erratum  ( 1 ) Personal communication to FlyBase  ( 12 ) Abstract  ( 27 ) FlyBase analysis  ( 2 ) DNA/RNA sequence record  ( 2 ) Computer file  ( 3 ) Curated genome annotation  ( 2 ) Patent  ( 1 ) Protein sequence record  ( 1 ) Automatic genome annotation  ( 1 ) Book  ( 1 )
Recent research papers ( 27 )
	Barry et al., 2011, Development 138(9): 1759--1769 The Drosophila STUbL protein Degringolade limits HES functions during embryogenesis. [FBrf0213458] Capalbo et al., 2011, Proc. Natl. Acad. Sci. U.S.A. 108(42): 17343--17348 Rab5 GTPase controls chromosome alignment through Lamin disassembly and relocation of the NuMA-like protein Mud to the poles during mitosis. [FBrf0216458] Chang et al., 2011, PLoS Genet. 7(2): e1001288 Pathogenic VCP/TER94 Alleles Are Dominant Actives and Contribute to Neurodegeneration by Altering Cellular ATP Level in a Drosophila IBMPFD Model. [FBrf0213008] Chen et al., 2011, PLoS ONE 6(1): e16127 Genetic interaction of centrosomin and bazooka in apical domain regulation in Drosophila photoreceptor. [FBrf0212822] Hadjieconomou et al., 2011, Nat. Methods 8(3): 260--266 Flybow: genetic multicolor cell labeling for neural circuit analysis in Drosophila melanogaster. [FBrf0213120] Lanson et al., 2011, Hum. Mol. Genet. 20(13): 2510--2523 A Drosophila model of FUS-related neurodegeneration reveals genetic interaction between FUS and TDP-43. [FBrf0213887] Maruyama et al., 2011, PLoS ONE 6(6): e20901 Genome-Wide Analysis Reveals a Major Role in Cell Fate Maintenance and an Unexpected Role in Endoreduplication for the Drosophila FoxA Gene Fork Head. [FBrf0214025] Wang et al., 2011, PLoS Genet. 7(8): e1002227 PP2A-Twins Is Antagonized by Greatwall and Collaborates with Polo for Cell Cycle Progression and Centrosome Attachment to Nuclei in Drosophila Embryos. [FBrf0214683] Zimek and Weber, 2011, Europ. J. Cell Biol. 90(4): 356--364 Flanking genes of an essential gene give information about the evolution of metazoa. [FBrf0213069] Bulchand et al., 2010, J. Cell Sci. 123(16): 2697--2707 Muscle wasted: a novel component of the Drosophila histone locus body required for muscle integrity. [FBrf0211459] Civelekoglu-Scholey et al., 2010, J. Cell Biol. 188(1): 49--68 Prometaphase spindle maintenance by an antagonistic motor-dependent force balance made robust by a disassembling lamin-B envelope. [FBrf0209681] Dialynas et al., 2010, Development 137(18): 3067--3077 The role of Drosophila Lamin C in muscle function and gene expression. [FBrf0211601] Filion et al., 2010, Cell 143(2): 212--224 Systematic protein location mapping reveals five principal chromatin types in Drosophila cells. [FBrf0212051] Gerbasi et al., 2010, Mol. Cell. Proteomics 9(9): 1866--1872 Proteomics Identification of Drosophila Small Interfering RNA-associated Factors. [FBrf0211707] Gettings et al., 2010, PLoS Biol. 8(6): e1000390 JNK Signalling Controls Remodelling of the Segment Boundary through Cell Reprogramming during Drosophila Morphogenesis. [FBrf0211014] Kalverda et al., 2010, Cell 140(3): 360--371 Nucleoporins Directly Stimulate Expression of Developmental and Cell-Cycle Genes Inside the Nucleoplasm. [FBrf0209913] Lancaster et al., 2010, PLoS Genet. 6(10): e1001179 The Meiotic Recombination Checkpoint Suppresses NHK-1 Kinase to Prevent Reorganisation of the Oocyte Nucleus in Drosophila. [FBrf0212208] McPhee et al., 2010, Nature 465(7301): 1093--1096 Activation of autophagy during cell death requires the engulfment receptor Draper. [FBrf0211145] Müller et al., 2010, EMBO J. 29(19): 3344--3357 Proteomic and functional analysis of the mitotic Drosophila centrosome. [FBrf0212030] Neely et al., 2010, Cell 143(4): 628--638 A Genome-wide Drosophila Screen for Heat Nociception Identifies α2δ3 as an Evolutionarily Conserved Pain Gene. [FBrf0212295] Polychronidou et al., 2010, Mol. Biol. Cell 21(19): 3409--3420 Farnesylated nuclear proteins Kugelkern and lamin Dm0 affect nuclear morphology by directly interacting with the nuclear membrane. [FBrf0214075] Siegrist et al., 2010, Curr. Biol. 20(7): 643--648 Inactivation of both foxo and reaper promotes long-term adult neurogenesis in Drosophila. [FBrf0210555] Taniue et al., 2010, Development 137(10): 1755--1764 Sunspot, a link between Wingless signaling and endoreplication in Drosophila. [FBrf0210642] van Steensel et al., 2010, Genome Res. 20(2): 190--200 Bayesian network analysis of targeting interactions in chromatin. [FBrf0209848] van Bemmel et al., 2010, PLoS ONE 5(11): e15013 The Insulator Protein SU(HW) Fine-Tunes Nuclear Lamina Interactions of the Drosophila Genome. [FBrf0212466] Wagner et al., 2010, Dev. Biol. 339(1): 1--13 The Drosophila LEM-domain protein MAN1 antagonizes BMP signaling at the neuromuscular junction and the wing crossveins. [FBrf0210050] Wang et al., 2010, Dev. Dyn. 239(11): 2813--2827 Drosophila variable nurse cells encodes arrest defective 1 (ARD1), the catalytic subunit of the major N-terminal acetyltransferase complex. [FBrf0212164] Show all research papers ...
Recent reviews ( 1 )
	Polychronidou and Großhans, 2011, Nucleus 2(1): 17--23 Determining nuclear shape: The role of farnesylated nuclear membrane proteins. [FBrf0213879] Show all reviews ...