HomeGene Dmel\LanA
| General Information | |||
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| Symbol | Dmel\LanA | Species | D. melanogaster |
| Name | Laminin A | Annotation symbol | CG10236 |
| Feature type | protein_coding_gene | FlyBase ID | FBgn0002526 |
| Created / Updated | 2003-12-01/2003-12-01 | ||
| Genomic Location | |||
| Chromosome (arm) | 3L | Recombination map | |
| Cytogenetic map | 65A8-65A9 | Sequence location | 3L:6,196,931..6,211,084 [-] |
| Map ( GBrowse ) | 
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Summary Information
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Automatically generated summary
See sections below for more information | The gene Laminin A is referred to in FlyBase by the symbol LanA (CG10236, FBgn0002526). It has the cytological map location 65A8-65A9. Its sequence location is 3L:6196931..6211084. Its molecular function is described as receptor binding. It is involved in the biological processes described with 12 unique terms, many of which group under: anatomical structure development; organ development; system development; regulation of biological process; cell motility; cell cycle; regulation of developmental process; regulation of locomotion; embryonic development; embryonic morphogenesis; M phase of meiotic cell cycle; central nervous system development; organ morphogenesis; regulation of cell adhesion; regulation of embryonic development. 25 alleles are reported. The phenotypes of these alleles are annotated with 29 unique terms, many of which group under: organ system; nervous system; peripheral nervous system; adult; adult segment; anatomical structure; embryonic nervous system; larval head segment; thoracic segment; embryonic head; adult tracheal system; extracellular matrix; morphogenetic furrow; late extended germ band embryo. It has one annotated transcript and one annotated polypeptide. | ||
| External Summaries | |||
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Detailed Mapping Data
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| FlyBase Computed Cytological Location | |||
Cytogenetic map Evidence for location 65A8-65A9
Limits computationally determined from genome sequence between P{PZ}l(3)0209402094 and P{lacW}l(3)L4060L4060
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| Experimentally Determined Cytological Location | |||
Cytogenetic map Notes References 65A-65A 64C-65C (determined by in situ hybridisation)
65A-65A (determined by in situ hybridisation)
65A10-65A11 (determined by in situ hybridisation)
65A10-65A11 (determined by in situ hybridisation)
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| Experimentally Determined Recombination Data | |||
| Location | |||
| Left of (cM) | |||
| Right of (cM) | |||
| Notes | |||
| Molecular Map Data | |||
Gene Order (in direction of increasing cytology)
References Gene Order (overall orientation not stated) References | |||
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Gene Model & Products
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Please see the
GBrowse view of
Dmel\LanA
for information on other features
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| Comments on Gene Model | |||
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Transcript Data
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| Annotated Transcripts | |||
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) | |||
| Additional Transcript Data & Comments | |||
| Reported size (kB) | 11.5 (compiled cDNA) 11.0 (northern blot) | ||
| Comments | The complete LanA sequence was reconstructed from
overlapping cDNA clones. | ||
| External Data | |||
| Crossreferences | |||
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Polypeptide Data
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| Annotated Polypeptides | |||
Name FlyBase ID
Predicted MW (kD)
Length (aa)
Theoretical pI
RefSeq ID
GenBank protein
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| Additional Polypeptide Data & Comments | |||
| Reported size (kD) | 3712 (aa) 3712 (aa); 409 (kD) 400 (kD observed) | ||
| Comments | |||
| External Data | |||
| Linkouts | PANTHER
- Protein classification by function, families, and pathways
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| Crossreferences | InterPro
domains - A database of protein families, domains, and functional sites
• Laminin B (IPR000034)
Laminin G (IPR001791)
EGF-like, laminin (IPR002049)
Laminin, N-terminal (IPR008211)
Galactose-binding like (IPR008979)
Concanavalin A-like lectin/glucanase (IPR008985)
Laminin I (IPR009254)
Laminin II (IPR010307)
Laminin G, subdomain 2 (IPR012680)
EGF-like region, conserved site (IPR013032)
Concanavalin A-like lectin/glucanase, subgroup (IPR013320)
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Sequences Consistent with the Gene Model
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| DDBJ
/
EMBL / GenBank | DNA sequence Protein sequence Name | ||
| UniProtKB/Swiss-Prot | |||
| UniProtKB/TrEMBL | |||
| Maps to | |||
| Does NOT map to | |||
| Identified with | |||
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Mapped Features & Mutations
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Please see
GBrowse
or insertion reports for information on insertions of transgenic
constructs and features not listed here
Type Symbol & Location Additional Notes References sequence variant LanA[9-32] 3L:6,208,381..6,208,819 comment=left break of P excision mutation linked_to=PstI-SalI_rfrag linked_to=EcoRI-PvuI_rfrag comment=right break of P excision mutation comment=position of restriction fragment on reference sequence inferred by FlyBase curator | |||
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External Data
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| Linkouts | DEDB
- Drosophila exon database: splicing graphs
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| Crossreferences | |||
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Expression Data
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| FlyBase-Curated Data | |||
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Transcript and Protein data | Please see the FlyBase Gene Expression Report for details of gene expression from the literature. | ||
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Summary of Transcript Expression
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Stage Tissue/Position
Reference
embryonic stage
somatic mesoderm
embryonic stage
interface glial cell
embryonic stage | stage >12
glial cell | lateral
embryonic stage | late
basal lamina <of> embryonic brain
embryonic stage | stage >12
hemocyte
embryonic stage | stage 11-12
procephalic mesoderm
embryonic stage
visceral mesoderm
embryonic stage | stage >12
embryonic/larval fat body
embryonic stage | late
basal lamina <of> ventral nerve cord
embryonic stage | late
basal lamina <of> sense organ
embryonic stage | late
basal lamina <of> embryonic/larval midgut
embryonic stage
ectoderm
embryonic stage
ventral midline | |||
| Marker for | |||
| Subcellular Localization | |||
| CV Term | |||
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Summary of Polypeptide Expression
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Stage Tissue/Position
Reference
embryonic stage
basal lamina <of> ventral nerve cord
embryonic stage | 10-13 hr
neuropile associated CNS glial cell
embryonic stage | 10-13 hr
anterior fascicle
embryonic stage
basal lamina <of> embryonic/larval midgut
embryonic stage
basal lamina <of> embryonic brain
embryonic stage | 10-13 hr
epidermis
embryonic stage | 10-13 hr
embryonic/larval digestive system
embryonic stage | 10-13 hr
myoblast <of> larval muscle system
embryonic stage
basal lamina <of> embryonic/larval spiracle
embryonic stage | 10-13 hr
posterior fascicle
embryonic stage
hemocyte
embryonic stage
basal lamina <of> larval muscle system
embryonic stage
glial cell
embryonic stage
embryonic/larval fat body | |||
| Marker for | |||
| Subcellular Localization | |||
| CV Term | basement membrane | ||
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Microarray Data
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Developmental timecourse, Costello et al., 2008 (Original data from Arbeitman et al., 2002) 
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External Data & Images
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| Linkouts | FLIGHT
- Cell culture data for RNAi and other high-throughput technologies
FlyAtlas
- Adult expression by tissue, using Affymetrix Dros2 array
GEO (NCBI)
- Gene expression data: microarray and other high-throughput technologies
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Alleles & Phenotypes
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Summary of Allele Phenotypes
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Lethality Allele Other Phenotypes Allele Phenotype manifest in Allele embryonic/larval pericardial cell & embryo abdominal 1 ventral oblique muscle 4 & embryo abdominal 2 ventral oblique muscle 4 & embryo abdominal 3 ventral oblique muscle 4 & embryo abdominal 4 ventral oblique muscle 4 & embryo abdominal 5 ventral oblique muscle 4 & embryo abdominal 6 ventral oblique muscle 4 & embryo abdominal 7 ventral oblique muscle 4 & embryo abdominal 1 ventral oblique muscle 5 & embryo abdominal 2 ventral oblique muscle 5 & embryo abdominal 3 ventral oblique muscle 5 & embryo abdominal 4 ventral oblique muscle 5 & embryo abdominal 5 ventral oblique muscle 5 & embryo abdominal 6 ventral oblique muscle 5 & embryo abdominal 7 ventral oblique muscle 5 & embryo abdominal 2 ventral oblique muscle 6 & embryo abdominal 3 ventral oblique muscle 6 & embryo abdominal 4 ventral oblique muscle 6 & embryo abdominal 5 ventral oblique muscle 6 & embryo abdominal 6 ventral oblique muscle 6 & embryo abdominal 7 ventral oblique muscle 6 & embryo abdominal 1 ventral acute muscle 3 | |||
