A Database of Drosophila Genes & Genomes

FB2013_03, released May 7th, 2013
 

Gene Dmel\LanA

General Information
SymbolDmel\LanASpeciesD. melanogaster
NameLaminin AAnnotation symbolCG10236
Feature typeprotein_coding_geneFlyBase IDFBgn0002526
Gene Model StatusCurrent Stock availability 7 publicly available
Also Known AslamA, Lan, Lam
Genomic Location
Chromosome (arm)3LRecombination map
Cytogenetic map65A8-65A9Sequence location3L:6,196,931..6,211,122 [-]

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Automatically generated summary

See sections below for more information
The gene Laminin A is referred to in FlyBase by the symbol Dmel\LanA (CG10236, FBgn0002526). It is a protein_coding_gene from Drosophila melanogaster. An electronic pipeline based on InterPro domains suggests that it has the molecular function: receptor binding. There is experimental evidence for 12 unique biological process terms, many of which group under: single-organism developmental process; system development; post-embryonic organ morphogenesis; immune response; growth; locomotory behavior; cell cycle; cellular component organization or biogenesis; neuromuscular process; biological regulation. 30 alleles are reported. The phenotypes of these alleles are annotated with: organ system subdivision; organ system; peripheral nervous system; external compound sense organ; adult segment; non-connected developing system; adult; extracellular matrix; adult trachea; late extended germ band embryo. It has one annotated transcript and one annotated polypeptide. Protein features are: Concanavalin A-like lectin/glucanase, subgroup; Concanavalin A-like lectin/glucanases superfamily; EGF-like, conserved site; EGF-like, laminin; Laminin B type IV; Laminin B, subgroup; Laminin G domain; Laminin I; Laminin II; Laminin, N-terminal. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of low expression. Peak expression observed within 06-24 hour embryonic stages. Summary of FlyAtlas Anatomical Expression Data: Many larval and adult organs/tissues expressed at moderate or high levels. Expression at high levels in the following post-embryonic organs or tissues: larval hindgut, adult heart, larval fat body. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, larval/adult central nervous system, adult crop, larval/adult midgut, adult hindgut, larval Malpighian tubules, adult fat body, larval salivary gland, larval trachea, adult ovary, adult male accessory gland, larval/adult carcass. Comments on Affy2 ProbeSet: ProbeSet 1641324_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of LanA. Gene sequence location is 3L:6196931..6211122.

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Description
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FB2013_03
FB2013_02
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FlyBase Computed Cytological Location
Cytogenetic map
Evidence for location
65A8-65A9  
Limits computationally determined from genome sequence between P{PZ}l(3)0209402094 and P{lacW}l(3)L4060L4060  
Experimentally Determined Cytological Location
Cytogenetic map
Notes
References
65A-65A  
64C-65C  
(determined by in situ hybridisation)  
65A-65A  
(determined by in situ hybridisation)  
65A10-65A11  
(determined by in situ hybridisation)  
65A10-65A11  
(determined by in situ hybridisation)  
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
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Please see the GBrowse view of Dmel\LanA for information on other features GBrowse View Help
To submit a correction to a gene model please use the Contact FlyBase form
detailed view FBtr0077003 FBtr0077014 FBpp0076711 FBpp0076722 FBti0075471 FBti0052650 FBti0143056 FBti0150219 FBti0109705 FBti0005089 FBti0007823 FBti0107483 FBti0103858 FBti0141152 FBti0107481 FBti0102724 FBti0110705 FBti0109278 FBti0016527 FBti0106204 FBti0068879 FBti0106115 FBti0109776 FBti0011762 FBti0100096 FBti0028940 FBti0103533 FBti0029021 FBti0040044 FBti0110938 FBti0034575 FBti0033891 FBti0037186 FBti0076923 FBti0011416 FBti0056118 FBti0108027 FBti0036009 FBti0036592 FBti0105443 FBti0100818 FBti0110809 FBti0105602 FBti0054904 FBti0011559 FBti0035933 FBti0029987 FBti0110405 FBti0146074 FBti0104732 FBti0016517 FBti0107632 FBti0107909 FBti0037506 FBti0103923 FBti0057537 FBti0104865 FBti0036078 FBti0102780 FBti0069564 FBti0070049 FBti0105121 FBti0070698 FBti0027930 FBti0104177 FBti0070073 FBti0037176 FBti0034945 FBti0107933 FBti0016453 FBti0004443 FBti0007829 FBti0107130 FBti0107968 FBti0100792 FBti0024081 FBti0059195 FBti0105584 FBti0107055 FBti0105784 FBti0068393 FBti0070317
Comments on Gene Model
Gene model reviewed during 5.45
Low-frequency RNA-seq exon junction(s) not annotated.
hide Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Associated CDS (aa)
FBtr0077014
  11690
  3712
Additional Transcript Data & Comments
Reported size (kB)
11.5 (compiled cDNA)
11.0 (northern blot)
Comments
External Data
Crossreferences
hide Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank protein
FBpp0076722  
411.1  
3712  
4.85  
Additional Polypeptide Data & Comments
Reported size (kDa)
3712 (aa); 409 (kD)
400 (kD observed)
Comments
External Data
Linkouts
Crossreferences
InterPro domains - A database of protein families, domains, and functional sites
hide Sequences Consistent with the Gene Model
DDBJ /
EMBL /
GenBank
DNA sequence
Protein sequence
Name
 
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL
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Mapped Features have been reorganized, please see this article for details.
Additional mapped features and mutations can be found on GBrowse or related reports.
Type
Symbol & Location
Additional Notes
References
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Linkouts
Crossreferences
hide Expression Data
hideTranscript Expression
No Assay Recorded
Stage
Tissue/Position (including subcellular localization)
Reference
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
Comment:anlage in statu nascendi
Comment:anlage in statu nascendi
Comment:anlage in statu nascendi
radioisotope in situ
Stage
Tissue/Position (including subcellular localization)
Reference
Additional Descriptive Data
LanA transcripts are expressed through most of embryogenesis with a peak in 6-9hr embryos.
LanA transcripts are detected in 4-6hr embryos, peak at 10-12hr, and then decline. Later peaks occur in early larvae, and late pupae. Developmental increases in Laminin transcripts are associated with periods of morphogenesis and precede those of Cg25C transcripts. Laminin transcripts appear in newly formed mesoderm and are later expressed in fat body, in some glial cells and prominantly in hemocytes found distributed around many organs where basement membrane deposition occurs such as brain, nerve cord, sensory organs, and various internal organs. LanA transcripts are detected at a lower level than LanB1 and LanB2 transcripts.
LanA expression is first detected during germ band extension in the mesoderm and at lower levels in the ectoderm including the neurogenic region. At ~8hr, the level of LanA expression dramatically increases in both the somatic and visceral mesoderm and expression in these tissues continues through the rest of embryonic development. At 8hr, expression in the ectoderm also increases but mainly in the epidermis and not in ectodermal derivatives such as the salivary glands and the CNS. The only LanA expression in the CNS is found along the midline. The interface glia were also tentatively identified as a site of LanA expression. The patterns of expression of LanA, LanB1, and LanB2 are nearly identical.
Marker for
Subcellular Localization
CV Term
hide Polypeptide Expression
No Assay Recorded
Stage
Tissue/Position (including subcellular localization)
Reference
immunolocalization
Stage
Tissue/Position (including subcellular localization)
Reference
Comment:reference states 10-13 hr AEL
Comment:reference states 10-13 hr AEL
Comment:reference states 10-13 hr AEL
Comment:10-13 hr AEL
Comment:10-13 hr AEL
Comment:10-13 hr AEL
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
western blot
Stage
Tissue/Position (including subcellular localization)
Reference
 
Comment:in conditioned medium
Additional Descriptive Data
In dissected embryos between 10-13 hours of development, LanA is detected in basement membrane throughout the embryo. These include basement membranes covering the inside of the epidermis, developing muscles, gut, and internal glands and organs. LanA is also detected in the dorsal basement membrane overlying the developing CNS and in a prominent pair of mesodermal cells just dorsal to the nervous system. The most striking staining in the developing CNS is seen along the axon pathways, including the longitudinal pathways, the commissural pathways, and the peripheral nerve roots. The glia around the peripheral nerve roots also stain. Staining is also observed surrounding clusters of peripheral sensory organs and their support cells. All three Laminin subunits show similar patterns of staining.
LanA protein is detected in embryonic hemocytes and fat body. In later embryos, LanA protein is observed in basement membranes surrounding the nerve cord, brain, gut, spiracles, sensory bodies, and muscles.
Marker for
Subcellular Localization (GO Cellular Component)
CV term
References
inferred from direct assay
hide Expression Deduced from Reporters
hide High-Throughput Expression Data
Associated Tools
Reference
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
hide FlyAtlas Anatomy Microarray

FlyAtlas Anatomical Expression Data

(FlyAtlas-RNA.adult)

(FlyAtlas-RNA.larva)


   Styles
   Scales

Summary of FlyAtlas Anatomical Expression Data: Many larval and adult organs/tissues expressed at moderate or high levels. Expression at high levels in the following post-embryonic organs or tissues: larval hindgut, adult heart, larval fat body. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, larval/adult central nervous system, adult crop, larval/adult midgut, adult hindgut, larval Malpighian tubules, adult fat body, larval salivary gland, larval trachea, adult ovary, adult male accessory gland, larval/adult carcass.
[download data (TSV)]

Guide to FlyAtlas expression level colors
 
No expression (0 - 9.999)
 
Low expression (10 - 99.999)
 
Moderate expression (100 - 499.999)
 
High level expression (500 - 999.999)
 
Very high expression (>999.999)

Linear, scaled to maximum expression level
Tissue   Expression Level
Larval Central Nervous System
 
 306.25
Larval Midgut
 
 156.7
Larval Hindgut
 
 1476.4
Larval Malpighian Tubules
 
 376.8
Larval Fat Body
 
 1076.5
Larval Salivary Gland
 
 106.7
Larval Trachea
 
 434.4
Larval Carcass
 
 491.25
Adult Head
 
 132.8
Adult Eye
 
 29.475
Adult Brain
 
 79.2
Adult Thoracic-Abdominal Ganglion
 
 179.1
Adult Crop
 
 375.4
Adult Midgut
 
 118.3
Adult Hindgut
 
 187.7
Adult Malpighian Tubules
 
 98.6
Adult Fat Body
 
 108.7
Adult Salivary Gland
 
 18.8
Adult Heart
 
 656.475
Adult VirginFemale Spermatheca
 
 37.2
Adult InseminatedFemale Spermatheca
 
 59.8
Adult Ovary
 
 199.3
Adult Testis
 
 61.5
Adult Male Accessory Gland
 
 305.4
Adult Carcass
 
 172
Expression Level Scale
 None 
 Low 
 Moderate 
 High 
 Very high 
Linear, scaled to Moderate expression
Tissue   Expression Level
Larval Central Nervous System
 
 306.25
Larval Midgut
 
 156.7
Larval Hindgut
 (1476.4)
Larval Malpighian Tubules
 
 376.8
Larval Fat Body
 (1076.5)
Larval Salivary Gland
 
 106.7
Larval Trachea
 
 434.4
Larval Carcass
 
 491.25
Adult Head
 
 132.8
Adult Eye
 
 29.475
Adult Brain
 
 79.2
Adult Thoracic-Abdominal Ganglion
 
 179.1
Adult Crop
 
 375.4
Adult Midgut
 
 118.3
Adult Hindgut
 
 187.7
Adult Malpighian Tubules
 
 98.6
Adult Fat Body
 
 108.7
Adult Salivary Gland
 
 18.8
Adult Heart
 (656.475)
Adult VirginFemale Spermatheca
 
 37.2
Adult InseminatedFemale Spermatheca
 
 59.8
Adult Ovary
 
 199.3
Adult Testis
 
 61.5
Adult Male Accessory Gland
 
 305.4
Adult Carcass
 
 172
Expression Level Scale
 None 
 Low 
 Moderate 
 High 
Linear, scaled to High level expression
Tissue   Expression Level
Larval Central Nervous System
 
 306.25
Larval Midgut
 
 156.7
Larval Hindgut
 (1476.4)
Larval Malpighian Tubules
 
 376.8
Larval Fat Body
 1076.5
Larval Salivary Gland
 
 106.7
Larval Trachea
 
 434.4
Larval Carcass
 
 491.25
Adult Head
 
 132.8
Adult Eye
 
 29.475
Adult Brain
 
 79.2
Adult Thoracic-Abdominal Ganglion
 
 179.1
Adult Crop
 
 375.4
Adult Midgut
 
 118.3
Adult Hindgut
 
 187.7
Adult Malpighian Tubules
 
 98.6
Adult Fat Body
 
 108.7
Adult Salivary Gland
 
 18.8
Adult Heart
 
 656.475
Adult VirginFemale Spermatheca
 
 37.2
Adult InseminatedFemale Spermatheca
 
 59.8
Adult Ovary
 
 199.3
Adult Testis
 
 61.5
Adult Male Accessory Gland
 
 305.4
Adult Carcass
 
 172
Expression Level Scale
 None 
 Low 
 Moderate 
 High 
 Very high 
Linear, scaled to Very high expression
Tissue   Expression Level
Larval Central Nervous System
 
 306.25
Larval Midgut
 
 156.7
Larval Hindgut
 
 1476.4
Larval Malpighian Tubules
 
 376.8
Larval Fat Body
 
 1076.5
Larval Salivary Gland
 
 106.7
Larval Trachea
 
 434.4
Larval Carcass
 
 491.25
Adult Head
 
 132.8
Adult Eye
 
 29.475
Adult Brain
 
 79.2
Adult Thoracic-Abdominal Ganglion
 
 179.1
Adult Crop
 
 375.4
Adult Midgut
 
 118.3
Adult Hindgut
 
 187.7
Adult Malpighian Tubules
 
 98.6
Adult Fat Body
 
 108.7
Adult Salivary Gland
 
 18.8
Adult Heart
 
 656.475
Adult VirginFemale Spermatheca
 
 37.2
Adult InseminatedFemale Spermatheca
 
 59.8
Adult Ovary
 
 199.3
Adult Testis
 
 61.5
Adult Male Accessory Gland
 
 305.4
Adult Carcass
 
 172
Expression Level Scale
 Very high 
log, scaled to maximum expression level
Tissue   Expression Level
Larval Central Nervous System
 
 306.25
Larval Midgut
 
 156.7
Larval Hindgut
 
 1476.4
Larval Malpighian Tubules
 
 376.8
Larval Fat Body
 
 1076.5
Larval Salivary Gland
 
 106.7
Larval Trachea
 
 434.4
Larval Carcass
 
 491.25
Adult Head
 
 132.8
Adult Eye
 
 29.475
Adult Brain
 
 79.2
Adult Thoracic-Abdominal Ganglion
 
 179.1
Adult Crop
 
 375.4
Adult Midgut
 
 118.3
Adult Hindgut
 
 187.7
Adult Malpighian Tubules
 
 98.6
Adult Fat Body
 
 108.7
Adult Salivary Gland
 
 18.8
Adult Heart
 
 656.475
Adult VirginFemale Spermatheca
 
 37.2
Adult InseminatedFemale Spermatheca
 
 59.8
Adult Ovary
 
 199.3
Adult Testis
 
 61.5
Adult Male Accessory Gland
 
 305.4
Adult Carcass
 
 172
Expression Level Scale
 None 
 Low 
 Moderate 
 High 
 Very high 
log, scaled to Moderate expression
Tissue   Expression Level
Larval Central Nervous System
 
 306.25
Larval Midgut
 
 156.7
Larval Hindgut
 (1476.4)
Larval Malpighian Tubules
 
 376.8
Larval Fat Body
 (1076.5)
Larval Salivary Gland
 
 106.7
Larval Trachea
 
 434.4
Larval Carcass
 
 491.25
Adult Head
 
 132.8
Adult Eye
 
 29.475
Adult Brain
 
 79.2
Adult Thoracic-Abdominal Ganglion
 
 179.1
Adult Crop
 
 375.4
Adult Midgut
 
 118.3
Adult Hindgut
 
 187.7
Adult Malpighian Tubules
 
 98.6
Adult Fat Body
 
 108.7
Adult Salivary Gland
 
 18.8
Adult Heart
 656.475
Adult VirginFemale Spermatheca
 
 37.2
Adult InseminatedFemale Spermatheca
 
 59.8
Adult Ovary
 
 199.3
Adult Testis
 
 61.5
Adult Male Accessory Gland
 
 305.4
Adult Carcass
 
 172
Expression Level Scale
 None 
 Low 
 Moderate 
 High 
log, scaled to High level expression
Tissue   Expression Level
Larval Central Nervous System
 
 306.25
Larval Midgut
 
 156.7
Larval Hindgut
 1476.4
Larval Malpighian Tubules
 
 376.8
Larval Fat Body
 1076.5
Larval Salivary Gland
 
 106.7
Larval Trachea
 
 434.4
Larval Carcass
 
 491.25
Adult Head
 
 132.8
Adult Eye
 
 29.475
Adult Brain
 
 79.2
Adult Thoracic-Abdominal Ganglion
 
 179.1
Adult Crop
 
 375.4
Adult Midgut
 
 118.3
Adult Hindgut
 
 187.7
Adult Malpighian Tubules
 
 98.6
Adult Fat Body
 
 108.7
Adult Salivary Gland
 
 18.8
Adult Heart
 
 656.475
Adult VirginFemale Spermatheca
 
 37.2
Adult InseminatedFemale Spermatheca
 
 59.8
Adult Ovary
 
 199.3
Adult Testis
 
 61.5
Adult Male Accessory Gland
 
 305.4
Adult Carcass
 
 172
Expression Level Scale
 None 
 Low 
 Moderate 
 High 
 Very high 
log, scaled to Very high expression
Tissue   Expression Level
Larval Central Nervous System
 
 306.25
Larval Midgut
 
 156.7
Larval Hindgut
 
 1476.4
Larval Malpighian Tubules
 
 376.8
Larval Fat Body
 
 1076.5
Larval Salivary Gland
 
 106.7
Larval Trachea
 
 434.4
Larval Carcass
 
 491.25
Adult Head
 
 132.8
Adult Eye
 
 29.475
Adult Brain
 
 79.2
Adult Thoracic-Abdominal Ganglion
 
 179.1
Adult Crop
 
 375.4
Adult Midgut
 
 118.3
Adult Hindgut
 
 187.7
Adult Malpighian Tubules
 
 98.6
Adult Fat Body
 
 108.7
Adult Salivary Gland
 
 18.8
Adult Heart
 
 656.475
Adult VirginFemale Spermatheca
 
 37.2
Adult InseminatedFemale Spermatheca
 
 59.8
Adult Ovary
 
 199.3
Adult Testis
 
 61.5
Adult Male Accessory Gland
 
 305.4
Adult Carcass
 
 172
Expression Level Scale
 None 
 Low 
 Moderate 
 High 
 Very high 
Heatmap
Tissue   Expression Level
Larval Central Nervous System
 
 
Larval Midgut
 
 
Larval Hindgut
 
 
Larval Malpighian Tubules
 
 
Larval Fat Body
 
 
Larval Salivary Gland
 
 
Larval Trachea
 
 
Larval Carcass
 
 
Adult Head
 
 
Adult Eye
 
 
Adult Brain
 
 
Adult Thoracic-Abdominal Ganglion
 
 
Adult Crop
 
 
Adult Midgut
 
 
Adult Hindgut
 
 
Adult Malpighian Tubules
 
 
Adult Fat Body
 
 
Adult Salivary Gland
 
 
Adult Heart
 
 
Adult VirginFemale Spermatheca
 
 
Adult InseminatedFemale Spermatheca
 
 
Adult Ovary
 
 
Adult Testis
 
 
Adult Male Accessory Gland
 
 
Adult Carcass
 
 

FlyAtlas Organ/Tissue Expression, larval vs. adult
Larval Expression Level Tissue Adult Expression Level
 
NA 
Head
 
 132.8
 
NA 
Eye
 
 29.475
 
NA 
Brain
 
 79.2
 
306.25 
Central Nervous System
 
 NA
 
NA 
Thoracic-Abdominal Ganglion
 
 179.1
 
NA 
Crop
 
 375.4
 
156.7 
Midgut
 
 118.3
 
1476.4 
Hindgut
 
 187.7
 
376.8 
Malpighian Tubules
 
 98.6
 
1076.5 
Fat Body
 
 108.7
 
106.7 
Salivary Gland
 
 no informative data
 
NA 
Heart
 
 656.475
 
434.4 
Trachea
 
 NA
 
NA 
VirginFemale Spermatheca
 
 37.2
 
NA 
InseminatedFemale Spermatheca
 
 59.8
 
NA 
Ovary
 
 199.3
 
NA 
Testis
 
 61.5
 
NA 
Male Accessory Gland
 
 305.4
 
491.25 
Carcass
 
 172

FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
hide modENCODE Anatomy RNA-Seq

modENCODE Tissue Expression Data

(modENCODE_mRNA-Seq_tissues)


   Styles
   Scales


[download data (TSV)]

Guide to modENCODE expression level colors
 
No/Extremely low expression (0 - 0)
 
Very low expression (1 - 3)
 
Low expression (4 - 10)
 
Moderate expression (11 - 25)
 
Moderately high expression (26 - 50)
 
High expression (51 - 100)
 
Very high expression (101 - 1000)
 
Extremely high expression (>1000)

Linear, scaled to maximum expression level
Tissue   Expression Level
imaginal disc, larvae L3 wandering
 
 38
central nervous system, larvae L3
 
 16
central nervous system, pupae P8
 
 13
head, virgin 1-day female
 
 18
head, virgin 4-day female
 
 6
head, virgin 20-day female
 
 6
head, mated 1-day female
 
 11
head, mated 4-day female
 
 8
head, mated 20-day female
 
 6
head, mated 1-day male
 
 8
head, mated 4-day male
 
 8
head, mated 20-day male
 
 7
salivary gland, larvae L3 wandering
 
 1
salivary gland, white prepupae
 
 17
digestive system, larvae L3 wandering
 
 9
digestive system, 1-day adult
 
 4
digestive system, 4-day adult
 
 5
digestive system, 20-day adult
 
 3
fat body, larvae L3 wandering
 
 55
fat body, white prepupae
 
 62
fat body, pupae P8
 
 65
carcass, larvae L3 wandering
 
 41
carcass, 1-day adult
 
 10
carcass, 4-day adult
 
 6
carcass, 20-day adult
 
 4
ovary, virgin 4-day female
 
 8
ovary, mated 4-day female
 
 7
testis, mated 4-day male
 
 1
accessory gland, mated 4-day male
 
 3
Expression Level Scale
 Very low 
 Low 
 Moderate 
 Moderately high 
 High 
Linear, scaled to Moderate expression
Tissue   Expression Level
imaginal disc, larvae L3 wandering
 (38)
central nervous system, larvae L3
 
 16
central nervous system, pupae P8
 
 13
head, virgin 1-day female
 
 18
head, virgin 4-day female
 
 6
head, virgin 20-day female
 
 6
head, mated 1-day female
 
 11
head, mated 4-day female
 
 8
head, mated 20-day female
 
 6
head, mated 1-day male
 
 8
head, mated 4-day male
 
 8
head, mated 20-day male
 
 7
salivary gland, larvae L3 wandering
 
 1
salivary gland, white prepupae
 
 17
digestive system, larvae L3 wandering
 
 9
digestive system, 1-day adult
 
 4
digestive system, 4-day adult
 
 5
digestive system, 20-day adult
 
 3
fat body, larvae L3 wandering
 (55)
fat body, white prepupae
 (62)
fat body, pupae P8
 (65)
carcass, larvae L3 wandering
 (41)
carcass, 1-day adult
 
 10
carcass, 4-day adult
 
 6
carcass, 20-day adult
 
 4
ovary, virgin 4-day female
 
 8
ovary, mated 4-day female
 
 7
testis, mated 4-day male
 
 1
accessory gland, mated 4-day male
 
 3
Expression Level Scale
 Very low 
 Low 
 Moderate 
 Moderately high 
Linear, scaled to High expression
Tissue   Expression Level
imaginal disc, larvae L3 wandering
 
 38
central nervous system, larvae L3
 
 16
central nervous system, pupae P8
 
 13
head, virgin 1-day female
 
 18
head, virgin 4-day female
 
 6
head, virgin 20-day female
 
 6
head, mated 1-day female
 
 11
head, mated 4-day female
 
 8
head, mated 20-day female
 
 6
head, mated 1-day male
 
 8
head, mated 4-day male
 
 8
head, mated 20-day male
 
 7
salivary gland, larvae L3 wandering
 
 1
salivary gland, white prepupae
 
 17
digestive system, larvae L3 wandering
 
 9
digestive system, 1-day adult
 
 4
digestive system, 4-day adult
 
 5
digestive system, 20-day adult
 
 3
fat body, larvae L3 wandering
 
 55
fat body, white prepupae
 
 62
fat body, pupae P8
 
 65
carcass, larvae L3 wandering
 
 41
carcass, 1-day adult
 
 10
carcass, 4-day adult
 
 6
carcass, 20-day adult
 
 4
ovary, virgin 4-day female
 
 8
ovary, mated 4-day female
 
 7
testis, mated 4-day male
 
 1
accessory gland, mated 4-day male
 
 3
Expression Level Scale
 Very low 
 Low 
 Moderate 
 Moderately high 
 High 
 Very high 
Linear, scaled to Extremely high expression
Tissue   Expression Level
imaginal disc, larvae L3 wandering
 
 38
central nervous system, larvae L3
 
 16
central nervous system, pupae P8
 
 13
head, virgin 1-day female
 
 18
head, virgin 4-day female
 
 6
head, virgin 20-day female
 
 6
head, mated 1-day female
 
 11
head, mated 4-day female
 
 8
head, mated 20-day female
 
 6
head, mated 1-day male
 
 8
head, mated 4-day male
 
 8
head, mated 20-day male
 
 7
salivary gland, larvae L3 wandering
 
 1
salivary gland, white prepupae
 
 17
digestive system, larvae L3 wandering
 
 9
digestive system, 1-day adult
 
 4
digestive system, 4-day adult
 
 5
digestive system, 20-day adult
 
 3
fat body, larvae L3 wandering
 
 55
fat body, white prepupae
 
 62
fat body, pupae P8
 
 65
carcass, larvae L3 wandering
 
 41
carcass, 1-day adult
 
 10
carcass, 4-day adult
 
 6
carcass, 20-day adult
 
 4
ovary, virgin 4-day female
 
 8
ovary, mated 4-day female
 
 7
testis, mated 4-day male
 
 1
accessory gland, mated 4-day male
 
 3
Expression Level Scale
 Extremely high 
log, scaled to maximum expression level
Tissue   Expression Level
imaginal disc, larvae L3 wandering
 
 38
central nervous system, larvae L3
 
 16
central nervous system, pupae P8
 
 13
head, virgin 1-day female
 
 18
head, virgin 4-day female
 
 6
head, virgin 20-day female
 
 6
head, mated 1-day female
 
 11
head, mated 4-day female
 
 8
head, mated 20-day female
 
 6
head, mated 1-day male
 
 8
head, mated 4-day male
 
 8
head, mated 20-day male
 
 7
salivary gland, larvae L3 wandering
 
 1
salivary gland, white prepupae
 
 17
digestive system, larvae L3 wandering
 
 9
digestive system, 1-day adult
 
 4
digestive system, 4-day adult
 
 5
digestive system, 20-day adult
 
 3
fat body, larvae L3 wandering
 
 55
fat body, white prepupae
 
 62
fat body, pupae P8
 
 65
carcass, larvae L3 wandering
 
 41
carcass, 1-day adult
 
 10
carcass, 4-day adult
 
 6
carcass, 20-day adult
 
 4
ovary, virgin 4-day female
 
 8
ovary, mated 4-day female
 
 7
testis, mated 4-day male
 
 1
accessory gland, mated 4-day male
 
 3
Expression Level Scale
 Very low 
 Low 
 Moderate 
 Moderately high 
 High 
log, scaled to Moderate expression
Tissue   Expression Level
imaginal disc, larvae L3 wandering
 (38)
central nervous system, larvae L3
 
 16
central nervous system, pupae P8
 
 13
head, virgin 1-day female
 
 18
head, virgin 4-day female
 
 6
head, virgin 20-day female
 
 6
head, mated 1-day female
 
 11
head, mated 4-day female
 
 8
head, mated 20-day female
 
 6
head, mated 1-day male
 
 8
head, mated 4-day male
 
 8
head, mated 20-day male
 
 7
salivary gland, larvae L3 wandering
 
 1
salivary gland, white prepupae
 
 17
digestive system, larvae L3 wandering
 
 9
digestive system, 1-day adult
 
 4
digestive system, 4-day adult
 
 5
digestive system, 20-day adult
 
 3
fat body, larvae L3 wandering
 (55)
fat body, white prepupae
 (62)
fat body, pupae P8
 (65)
carcass, larvae L3 wandering
 (41)
carcass, 1-day adult
 
 10
carcass, 4-day adult
 
 6
carcass, 20-day adult
 
 4
ovary, virgin 4-day female
 
 8
ovary, mated 4-day female
 
 7
testis, mated 4-day male
 
 1
accessory gland, mated 4-day male
 
 3
Expression Level Scale
 Very low 
 Low 
 Moderate 
 Moderately high 
log, scaled to High expression
Tissue   Expression Level
imaginal disc, larvae L3 wandering
 
 38
central nervous system, larvae L3
 
 16
central nervous system, pupae P8
 
 13
head, virgin 1-day female
 
 18
head, virgin 4-day female
 
 6
head, virgin 20-day female
 
 6
head, mated 1-day female
 
 11
head, mated 4-day female
 
 8
head, mated 20-day female
 
 6
head, mated 1-day male
 
 8
head, mated 4-day male
 
 8
head, mated 20-day male
 
 7
salivary gland, larvae L3 wandering
 
 1
salivary gland, white prepupae
 
 17
digestive system, larvae L3 wandering
 
 9
digestive system, 1-day adult
 
 4
digestive system, 4-day adult
 
 5
digestive system, 20-day adult
 
 3
fat body, larvae L3 wandering
 
 55
fat body, white prepupae
 
 62
fat body, pupae P8
 
 65
carcass, larvae L3 wandering
 
 41
carcass, 1-day adult
 
 10
carcass, 4-day adult
 
 6
carcass, 20-day adult
 
 4
ovary, virgin 4-day female
 
 8
ovary, mated 4-day female
 
 7
testis, mated 4-day male
 
 1
accessory gland, mated 4-day male
 
 3
Expression Level Scale
 Very low 
 Low 
 Moderate 
 Moderately high 
 High 
 Very high 
log, scaled to Extremely high expression
Tissue   Expression Level
imaginal disc, larvae L3 wandering
 
 38
central nervous system, larvae L3
 
 16
central nervous system, pupae P8
 
 13
head, virgin 1-day female
 
 18
head, virgin 4-day female
 
 6
head, virgin 20-day female
 
 6
head, mated 1-day female
 
 11
head, mated 4-day female
 
 8
head, mated 20-day female
 
 6
head, mated 1-day male
 
 8
head, mated 4-day male
 
 8
head, mated 20-day male
 
 7
salivary gland, larvae L3 wandering
 
 1
salivary gland, white prepupae
 
 17
digestive system, larvae L3 wandering
 
 9
digestive system, 1-day adult
 
 4
digestive system, 4-day adult
 
 5
digestive system, 20-day adult
 
 3
fat body, larvae L3 wandering
 
 55
fat body, white prepupae
 
 62
fat body, pupae P8
 
 65
carcass, larvae L3 wandering
 
 41
carcass, 1-day adult
 
 10
carcass, 4-day adult
 
 6
carcass, 20-day adult
 
 4
ovary, virgin 4-day female
 
 8
ovary, mated 4-day female
 
 7
testis, mated 4-day male
 
 1
accessory gland, mated 4-day male
 
 3
Expression Level Scale
 Very low 
 Low 
 Moderate 
 Moderately high 
 High 
 Very high 
 Extremely high 
Heatmap
Tissue   Expression Level
imaginal disc, larvae L3 wandering
 
 
central nervous system, larvae L3
 
 
central nervous system, pupae P8
 
 
head, virgin 1-day female
 
 
head, virgin 4-day female
 
 
head, virgin 20-day female
 
 
head, mated 1-day female
 
 
head, mated 4-day female
 
 
head, mated 20-day female
 
 
head, mated 1-day male
 
 
head, mated 4-day male
 
 
head, mated 20-day male
 
 
salivary gland, larvae L3 wandering
 
 
salivary gland, white prepupae
 
 
digestive system, larvae L3 wandering
 
 
digestive system, 1-day adult
 
 
digestive system, 4-day adult
 
 
digestive system, 20-day adult
 
 
fat body, larvae L3 wandering
 
 
fat body, white prepupae
 
 
fat body, pupae P8
 
 
carcass, larvae L3 wandering
 
 
carcass, 1-day adult
 
 
carcass, 4-day adult
 
 
carcass, 20-day adult
 
 
ovary, virgin 4-day female
 
 
ovary, mated 4-day female
 
 
testis, mated 4-day male
 
 
accessory gland, mated 4-day male
 
 

hide modENCODE Development RNA-Seq

modENCODE Temporal Expression Data

(modENCODE_mRNA-Seq_U)


   Styles
   Scales

Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of low expression. Peak expression observed within 06-24 hour embryonic stages.
[download data (TSV)]

Guide to modENCODE expression level colors
 
No/Extremely low expression (0 - 0)
 
Very low expression (1 - 3)
 
Low expression (4 - 10)
 
Moderate expression (11 - 25)
 
Moderately high expression (26 - 50)
 
High expression (51 - 100)
 
Very high expression (101 - 1000)
 
Extremely high expression (>1000)

Linear, scaled to maximum expression level
Developmental Stage   Expression Level
embryo 00-02hr
 
 2
embryo 02-04hr
 
 15
embryo 04-06hr
 
 59
embryo 06-08hr
 
 182
embryo 08-10hr
 
 219
embryo 10-12hr
 
 147
embryo 12-14hr
 
 282
embryo 14-16hr
 
 314
embryo 16-18hr
 
 245
embryo 18-20hr
 
 146
embryo 20-22hr
 
 66
embryo 22-24hr
 
 77
larva L1
 
 105
larva L2
 
 110
larva L3 12hr old
 
 62
larva L3 puffstage 1-2
 
 30
larva L3 puffstage 3-6
 
 51
larva L3 puffstage 7-9
 
 54
white prepupae new
 
 61
white prepupae 12hr
 
 26
white prepupae 24hr
 
 42
pupae 2d postWPP
 
 39
pupae 3d postWPP
 
 60
pupae 4d postWPP
 
 20
adult male 01day
 
 10
adult male 05day
 
 6
adult male 30day
 
 4
adult female 01day
 
 24
adult female 05day
 
 15
adult female 30day
 
 13
Expression Level Scale
 Very low 
 Low 
 Moderate 
 Moderately high 
 High 
 Very high 
Linear, scaled to Moderate expression
Developmental Stage   Expression Level
embryo 00-02hr
 
 2
embryo 02-04hr
 
 15
embryo 04-06hr
 (59)
embryo 06-08hr
 (182)
embryo 08-10hr
 (219)
embryo 10-12hr
 (147)
embryo 12-14hr
 (282)
embryo 14-16hr
 (314)
embryo 16-18hr
 (245)
embryo 18-20hr
 (146)
embryo 20-22hr
 (66)
embryo 22-24hr
 (77)
larva L1
 (105)
larva L2
 (110)
larva L3 12hr old
 (62)
larva L3 puffstage 1-2
 (30)
larva L3 puffstage 3-6
 (51)
larva L3 puffstage 7-9
 (54)
white prepupae new
 (61)
white prepupae 12hr
 26
white prepupae 24hr
 (42)
pupae 2d postWPP
 (39)
pupae 3d postWPP
 (60)
pupae 4d postWPP
 
 20
adult male 01day
 
 10
adult male 05day
 
 6
adult male 30day
 
 4
adult female 01day
 
 24
adult female 05day
 
 15
adult female 30day
 
 13
Expression Level Scale
 Very low 
 Low 
 Moderate 
 Moderately high 
Linear, scaled to High expression
Developmental Stage   Expression Level
embryo 00-02hr
 
 2
embryo 02-04hr
 
 15
embryo 04-06hr
 
 59
embryo 06-08hr
 (182)
embryo 08-10hr
 (219)
embryo 10-12hr
 (147)
embryo 12-14hr
 (282)
embryo 14-16hr
 (314)
embryo 16-18hr
 (245)
embryo 18-20hr
 (146)
embryo 20-22hr
 
 66
embryo 22-24hr
 
 77
larva L1
 105
larva L2
 (110)
larva L3 12hr old
 
 62
larva L3 puffstage 1-2
 
 30
larva L3 puffstage 3-6
 
 51
larva L3 puffstage 7-9
 
 54
white prepupae new
 
 61
white prepupae 12hr
 
 26
white prepupae 24hr
 
 42
pupae 2d postWPP
 
 39
pupae 3d postWPP
 
 60
pupae 4d postWPP
 
 20
adult male 01day
 
 10
adult male 05day
 
 6
adult male 30day
 
 4
adult female 01day
 
 24
adult female 05day
 
 15
adult female 30day
 
 13
Expression Level Scale
 Very low 
 Low 
 Moderate 
 Moderately high 
 High 
 Very high 
Linear, scaled to Extremely high expression
Developmental Stage   Expression Level
embryo 00-02hr
 
 2
embryo 02-04hr
 
 15
embryo 04-06hr
 
 59
embryo 06-08hr
 
 182
embryo 08-10hr
 
 219
embryo 10-12hr
 
 147
embryo 12-14hr
 
 282
embryo 14-16hr
 
 314
embryo 16-18hr
 
 245
embryo 18-20hr
 
 146
embryo 20-22hr
 
 66
embryo 22-24hr
 
 77
larva L1
 
 105
larva L2
 
 110
larva L3 12hr old
 
 62
larva L3 puffstage 1-2
 
 30
larva L3 puffstage 3-6
 
 51
larva L3 puffstage 7-9
 
 54
white prepupae new
 
 61
white prepupae 12hr
 
 26
white prepupae 24hr
 
 42
pupae 2d postWPP
 
 39
pupae 3d postWPP
 
 60
pupae 4d postWPP
 
 20
adult male 01day
 
 10
adult male 05day
 
 6
adult male 30day
 
 4
adult female 01day
 
 24
adult female 05day
 
 15
adult female 30day
 
 13
Expression Level Scale
 Extremely high 
log, scaled to maximum expression level
Developmental Stage   Expression Level
embryo 00-02hr
 
 2
embryo 02-04hr
 
 15
embryo 04-06hr
 
 59
embryo 06-08hr
 
 182
embryo 08-10hr
 
 219
embryo 10-12hr
 
 147
embryo 12-14hr
 
 282
embryo 14-16hr
 
 314
embryo 16-18hr
 
 245
embryo 18-20hr
 
 146
embryo 20-22hr
 
 66
embryo 22-24hr
 
 77
larva L1
 
 105
larva L2
 
 110
larva L3 12hr old
 
 62
larva L3 puffstage 1-2
 
 30
larva L3 puffstage 3-6
 
 51
larva L3 puffstage 7-9
 
 54
white prepupae new
 
 61
white prepupae 12hr
 
 26
white prepupae 24hr
 
 42
pupae 2d postWPP
 
 39
pupae 3d postWPP
 
 60
pupae 4d postWPP
 
 20
adult male 01day
 
 10
adult male 05day
 
 6
adult male 30day
 
 4
adult female 01day
 
 24
adult female 05day
 
 15
adult female 30day
 
 13
Expression Level Scale
 Very low 
 Low 
 Moderate 
 Moderately high 
 High 
 Very high 
log, scaled to Moderate expression
Developmental Stage   Expression Level
embryo 00-02hr
 
 2
embryo 02-04hr
 
 15
embryo 04-06hr
 (59)
embryo 06-08hr
 (182)
embryo 08-10hr
 (219)
embryo 10-12hr
 (147)
embryo 12-14hr
 (282)
embryo 14-16hr
 (314)
embryo 16-18hr
 (245)
embryo 18-20hr
 (146)
embryo 20-22hr
 (66)
embryo 22-24hr
 (77)
larva L1
 (105)
larva L2
 (110)
larva L3 12hr old
 (62)
larva L3 puffstage 1-2
 30
larva L3 puffstage 3-6
 (51)
larva L3 puffstage 7-9
 (54)
white prepupae new
 (61)
white prepupae 12hr
 26
white prepupae 24hr
 (42)
pupae 2d postWPP
 (39)
pupae 3d postWPP
 (60)
pupae 4d postWPP
 
 20
adult male 01day
 
 10
adult male 05day
 
 6
adult male 30day
 
 4
adult female 01day
 
 24
adult female 05day
 
 15
adult female 30day
 
 13
Expression Level Scale
 Very low 
 Low 
 Moderate 
 Moderately high 
log, scaled to High expression
Developmental Stage   Expression Level
embryo 00-02hr
 
 2
embryo 02-04hr
 
 15
embryo 04-06hr
 
 59
embryo 06-08hr
 (182)
embryo 08-10hr
 (219)
embryo 10-12hr
 (147)
embryo 12-14hr
 (282)
embryo 14-16hr
 (314)
embryo 16-18hr
 (245)
embryo 18-20hr
 (146)
embryo 20-22hr
 
 66
embryo 22-24hr
 
 77
larva L1
 105
larva L2
 110
larva L3 12hr old
 
 62
larva L3 puffstage 1-2
 
 30
larva L3 puffstage 3-6
 
 51
larva L3 puffstage 7-9
 
 54
white prepupae new
 
 61
white prepupae 12hr
 
 26
white prepupae 24hr
 
 42
pupae 2d postWPP
 
 39
pupae 3d postWPP
 
 60
pupae 4d postWPP
 
 20
adult male 01day
 
 10
adult male 05day
 
 6
adult male 30day
 
 4
adult female 01day
 
 24
adult female 05day
 
 15
adult female 30day
 
 13
Expression Level Scale
 Very low 
 Low 
 Moderate 
 Moderately high 
 High 
 Very high 
log, scaled to Extremely high expression
Developmental Stage   Expression Level
embryo 00-02hr
 
 2
embryo 02-04hr
 
 15
embryo 04-06hr
 
 59
embryo 06-08hr
 
 182
embryo 08-10hr
 
 219
embryo 10-12hr
 
 147
embryo 12-14hr
 
 282
embryo 14-16hr
 
 314
embryo 16-18hr
 
 245
embryo 18-20hr
 
 146
embryo 20-22hr
 
 66
embryo 22-24hr
 
 77
larva L1
 
 105
larva L2
 
 110
larva L3 12hr old
 
 62
larva L3 puffstage 1-2
 
 30
larva L3 puffstage 3-6
 
 51
larva L3 puffstage 7-9
 
 54
white prepupae new
 
 61
white prepupae 12hr
 
 26
white prepupae 24hr
 
 42
pupae 2d postWPP
 
 39
pupae 3d postWPP
 
 60
pupae 4d postWPP
 
 20
adult male 01day
 
 10
adult male 05day
 
 6
adult male 30day
 
 4
adult female 01day
 
 24
adult female 05day
 
 15
adult female 30day
 
 13
Expression Level Scale
 Very low 
 Low 
 Moderate 
 Moderately high 
 High 
 Very high 
 Extremely high 
Heatmap
Developmental Stage   Expression Level
embryo 00-02hr
 
 
embryo 02-04hr
 
 
embryo 04-06hr
 
 
embryo 06-08hr
 
 
embryo 08-10hr
 
 
embryo 10-12hr
 
 
embryo 12-14hr
 
 
embryo 14-16hr
 
 
embryo 16-18hr
 
 
embryo 18-20hr
 
 
embryo 20-22hr
 
 
embryo 22-24hr
 
 
larva L1
 
 
larva L2
 
 
larva L3 12hr old
 
 
larva L3 puffstage 1-2
 
 
larva L3 puffstage 3-6
 
 
larva L3 puffstage 7-9
 
 
white prepupae new
 
 
white prepupae 12hr
 
 
white prepupae 24hr
 
 
pupae 2d postWPP
 
 
pupae 3d postWPP
 
 
pupae 4d postWPP
 
 
adult male 01day
 
 
adult male 05day
 
 
adult male 30day
 
 
adult female 01day
 
 
adult female 05day
 
 
adult female 30day
 
 

modENCODE Temporal Expression Data (Graveley et al., 2011)
hide modENCODE Cell Lines RNA-Seq

modENCODE Cell Line Expression Data

(modENCODE_mRNA-Seq_cell.A)

(modENCODE_mRNA-Seq_cell.B)


   Styles
   Scales


[download data (TSV)]

Guide to modENCODE expression level colors
 
No/Extremely low expression (0 - 0)
 
Very low expression (1 - 3)
 
Low expression (4 - 10)
 
Moderate expression (11 - 25)
 
Moderately high expression (26 - 50)
 
High expression (51 - 100)
 
Very high expression (101 - 1000)
 
Extremely high expression (>1000)

Linear, scaled to maximum expression level
Cell Line   Expression Level
Schneider line 2 S2R+
 
 400
Schneider line 2 Sg4
 
 233
embryonic 1182-4H
 
 812
embryonic GM2
 
 157
embryonic Kc167
 
 153
embryonic S1
 
 233
embryonic S3
 
 161
leg disc CME L1
 
 430
wing disc CME-W2
 
 453
wing disc ML-DmD8
 
 193
wing disc ML-DmD9
 
 375
wing disc ML-DmD16-c3
 
 432
wing disc ML-DmD21
 
 64
wing disc ML-DmD32
 
 364
haltere disc ML-DmD17-c3
 
 363
eye-antennal disc ML-DmD11
 
 329
antennal disc ML-DmD20-c5
 
 190
mixed discs ML-DmD4-c1
 
 160
CNS ML-DmBG1-c1
 
 175
CNS ML-DmBG2-c2
 
 164
tumorous blood cells mbn2
 
 263
ovary fGS/OSS
 
 153
ovary OSC
 
 132
ovary OSS
 
 58
Expression Level Scale
 Very low 
 Low 
 Moderate 
 Moderately high 
 High 
 Very high 
Linear, scaled to Moderate expression
Cell Line   Expression Level
Schneider line 2 S2R+
 (400)
Schneider line 2 Sg4
 (233)
embryonic 1182-4H
 (812)
embryonic GM2
 (157)
embryonic Kc167
 (153)
embryonic S1
 (233)
embryonic S3
 (161)
leg disc CME L1
 (430)
wing disc CME-W2
 (453)
wing disc ML-DmD8
 (193)
wing disc ML-DmD9
 (375)
wing disc ML-DmD16-c3
 (432)
wing disc ML-DmD21
 (64)
wing disc ML-DmD32
 (364)
haltere disc ML-DmD17-c3
 (363)
eye-antennal disc ML-DmD11
 (329)
antennal disc ML-DmD20-c5
 (190)
mixed discs ML-DmD4-c1
 (160)
CNS ML-DmBG1-c1
 (175)
CNS ML-DmBG2-c2
 (164)
tumorous blood cells mbn2
 (263)
ovary fGS/OSS
 (153)
ovary OSC
 (132)
ovary OSS
 (58)
Expression Level Scale
 Very low 
 Low 
 Moderate 
 Moderately high 
Linear, scaled to High expression
Cell Line   Expression Level
Schneider line 2 S2R+
 (400)
Schneider line 2 Sg4
 (233)
embryonic 1182-4H
 (812)
embryonic GM2
 (157)
embryonic Kc167
 (153)
embryonic S1
 (233)
embryonic S3
 (161)
leg disc CME L1
 (430)
wing disc CME-W2
 (453)
wing disc ML-DmD8
 (193)
wing disc ML-DmD9
 (375)
wing disc ML-DmD16-c3
 (432)
wing disc ML-DmD21
 
 64
wing disc ML-DmD32
 (364)
haltere disc ML-DmD17-c3
 (363)
eye-antennal disc ML-DmD11
 (329)
antennal disc ML-DmD20-c5
 (190)
mixed discs ML-DmD4-c1
 (160)
CNS ML-DmBG1-c1
 (175)
CNS ML-DmBG2-c2
 (164)
tumorous blood cells mbn2
 (263)
ovary fGS/OSS
 (153)
ovary OSC
 (132)
ovary OSS
 
 58
Expression Level Scale
 Very low 
 Low 
 Moderate 
 Moderately high 
 High 
 Very high 
Linear, scaled to Extremely high expression
Cell Line   Expression Level
Schneider line 2 S2R+
 
 400
Schneider line 2 Sg4
 
 233
embryonic 1182-4H
 
 812
embryonic GM2
 
 157
embryonic Kc167
 
 153
embryonic S1
 
 233
embryonic S3
 
 161
leg disc CME L1
 
 430
wing disc CME-W2
 
 453
wing disc ML-DmD8
 
 193
wing disc ML-DmD9
 
 375
wing disc ML-DmD16-c3
 
 432
wing disc ML-DmD21
 
 64
wing disc ML-DmD32
 
 364
haltere disc ML-DmD17-c3
 
 363
eye-antennal disc ML-DmD11
 
 329
antennal disc ML-DmD20-c5
 
 190
mixed discs ML-DmD4-c1
 
 160
CNS ML-DmBG1-c1
 
 175
CNS ML-DmBG2-c2
 
 164
tumorous blood cells mbn2
 
 263
ovary fGS/OSS
 
 153
ovary OSC
 
 132
ovary OSS
 
 58
Expression Level Scale
 Extremely high 
log, scaled to maximum expression level
Cell Line   Expression Level
Schneider line 2 S2R+
 
 400
Schneider line 2 Sg4
 
 233
embryonic 1182-4H
 
 812
embryonic GM2
 
 157
embryonic Kc167
 
 153
embryonic S1
 
 233
embryonic S3
 
 161
leg disc CME L1
 
 430
wing disc CME-W2
 
 453
wing disc ML-DmD8
 
 193
wing disc ML-DmD9
 
 375
wing disc ML-DmD16-c3
 
 432
wing disc ML-DmD21
 
 64
wing disc ML-DmD32
 
 364
haltere disc ML-DmD17-c3
 
 363
eye-antennal disc ML-DmD11
 
 329
antennal disc ML-DmD20-c5
 
 190
mixed discs ML-DmD4-c1
 
 160
CNS ML-DmBG1-c1
 
 175
CNS ML-DmBG2-c2
 
 164
tumorous blood cells mbn2
 
 263
ovary fGS/OSS
 
 153
ovary OSC
 
 132
ovary OSS
 
 58
Expression Level Scale
 Very low 
 Low 
 Moderate 
 Moderately high 
 High 
 Very high 
 Extremely high 
log, scaled to Moderate expression
Cell Line   Expression Level
Schneider line 2 S2R+
 (400)
Schneider line 2 Sg4
 (233)
embryonic 1182-4H
 (812)
embryonic GM2
 (157)
embryonic Kc167
 (153)
embryonic S1
 (233)
embryonic S3
 (161)
leg disc CME L1
 (430)
wing disc CME-W2
 (453)
wing disc ML-DmD8
 (193)
wing disc ML-DmD9
 (375)
wing disc ML-DmD16-c3
 (432)
wing disc ML-DmD21
 (64)
wing disc ML-DmD32
 (364)
haltere disc ML-DmD17-c3
 (363)
eye-antennal disc ML-DmD11
 (329)
antennal disc ML-DmD20-c5
 (190)
mixed discs ML-DmD4-c1
 (160)
CNS ML-DmBG1-c1
 (175)
CNS ML-DmBG2-c2
 (164)
tumorous blood cells mbn2
 (263)
ovary fGS/OSS
 (153)
ovary OSC
 (132)
ovary OSS
 (58)
Expression Level Scale
 Very low 
 Low 
 Moderate 
 Moderately high 
log, scaled to High expression
Cell Line   Expression Level
Schneider line 2 S2R+
 (400)
Schneider line 2 Sg4
 (233)
embryonic 1182-4H
 (812)
embryonic GM2
 (157)
embryonic Kc167
 (153)
embryonic S1
 (233)
embryonic S3
 (161)
leg disc CME L1
 (430)
wing disc CME-W2
 (453)
wing disc ML-DmD8
 (193)
wing disc ML-DmD9
 (375)
wing disc ML-DmD16-c3
 (432)
wing disc ML-DmD21
 
 64
wing disc ML-DmD32
 (364)
haltere disc ML-DmD17-c3
 (363)
eye-antennal disc ML-DmD11
 (329)
antennal disc ML-DmD20-c5
 (190)
mixed discs ML-DmD4-c1
 (160)
CNS ML-DmBG1-c1
 (175)
CNS ML-DmBG2-c2
 (164)
tumorous blood cells mbn2
 (263)
ovary fGS/OSS
 (153)
ovary OSC
 132
ovary OSS
 
 58
Expression Level Scale
 Very low 
 Low 
 Moderate 
 Moderately high 
 High 
 Very high 
log, scaled to Extremely high expression
Cell Line   Expression Level
Schneider line 2 S2R+
 
 400
Schneider line 2 Sg4
 
 233
embryonic 1182-4H
 
 812
embryonic GM2
 
 157
embryonic Kc167
 
 153
embryonic S1
 
 233
embryonic S3
 
 161
leg disc CME L1
 
 430
wing disc CME-W2
 
 453
wing disc ML-DmD8
 
 193
wing disc ML-DmD9
 
 375
wing disc ML-DmD16-c3
 
 432
wing disc ML-DmD21
 
 64
wing disc ML-DmD32
 
 364
haltere disc ML-DmD17-c3
 
 363
eye-antennal disc ML-DmD11
 
 329
antennal disc ML-DmD20-c5
 
 190
mixed discs ML-DmD4-c1
 
 160
CNS ML-DmBG1-c1
 
 175
CNS ML-DmBG2-c2
 
 164
tumorous blood cells mbn2
 
 263
ovary fGS/OSS
 
 153
ovary OSC
 
 132
ovary OSS
 
 58
Expression Level Scale
 Very low 
 Low 
 Moderate 
 Moderately high 
 High 
 Very high 
 Extremely high 
Heatmap
Cell Line   Expression Level
Schneider line 2 S2R+
 
 
Schneider line 2 Sg4
 
 
embryonic 1182-4H
 
 
embryonic GM2
 
 
embryonic Kc167
 
 
embryonic S1
 
 
embryonic S3
 
 
leg disc CME L1
 
 
wing disc CME-W2
 
 
wing disc ML-DmD8
 
 
wing disc ML-DmD9
 
 
wing disc ML-DmD16-c3
 
 
wing disc ML-DmD21
 
 
wing disc ML-DmD32
 
 
haltere disc ML-DmD17-c3
 
 
eye-antennal disc ML-DmD11
 
 
antennal disc ML-DmD20-c5
 
 
mixed discs ML-DmD4-c1
 
 
CNS ML-DmBG1-c1
 
 
CNS ML-DmBG2-c2
 
 
tumorous blood cells mbn2
 
 
ovary fGS/OSS
 
 
ovary OSC
 
 
ovary OSS
 
 

hide modENCODE Treatments RNA-Seq

modENCODE Treatment Expression Data

(modENCODE_mRNA-Seq_treatments)


   Styles
   Scales


[download data (TSV)]

Guide to modENCODE expression level colors
 
No/Extremely low expression (0 - 0)
 
Very low expression (1 - 3)
 
Low expression (4 - 10)
 
Moderate expression (11 - 25)
 
Moderately high expression (26 - 50)
 
High expression (51 - 100)
 
Very high expression (101 - 1000)
 
Extremely high expression (>1000)

Linear, scaled to maximum expression level
Treatment   Expression Level
extended cold, 4-day adult
 
 10
cold shock, 4-day adult
 
 9
heat shock, 4-day adult
 
 16
Cadmium 50 mM 6 hrs, larvae L3
 
 14
Cadmium 50 mM 12 hrs, larvae L3
 
 16
Cadmium 50 mM 48 hrs, 4-day adult
 
 24
Cadmium 100 mM 48 hrs, 4-day adult
 
 4
Copper 0.5 mM 12 hrs, larvae L3
 
 18
Copper 15 mM 48 hrs, 4-day adult
 
 5
Zinc 5 mM 12 hrs, larvae L3
 
 16
Zinc 4.5 mM 48 hrs, 4-day adult
 
 8
Ethanol 2.5% 3 hrs, larvae L3
 
 7
Ethanol 5% 3 hrs, larvae L3
 
 15
Ethanol 10% 3 hrs, larvae L3
 
 17
Caffeine 1.5 mg/ml 4 hrs, larvae L3
 
 17
Caffeine 2.5 mg/ml 48 hrs, 4-day adult
 
 5
Caffeine 25 mg/ml 48 hrs, 4-day adult
 
 8
Paraquat 5 mM 48 hrs, 4-day adult
 
 8
Paraquat 10 mM 48 hrs, 4-day adult
 
 14
Rotenone 2 μg 12 hrs, larvae L3
 
 14
Rotenone 8 μg 12 hrs, larvae L3
 
 15
Expression Level Scale
 Very low 
 Low 
 Moderate 
 Moderately high 
Linear, scaled to Moderate expression
Treatment   Expression Level
extended cold, 4-day adult
 
 10
cold shock, 4-day adult
 
 9
heat shock, 4-day adult
 
 16
Cadmium 50 mM 6 hrs, larvae L3
 
 14
Cadmium 50 mM 12 hrs, larvae L3
 
 16
Cadmium 50 mM 48 hrs, 4-day adult
 
 24
Cadmium 100 mM 48 hrs, 4-day adult
 
 4
Copper 0.5 mM 12 hrs, larvae L3
 
 18
Copper 15 mM 48 hrs, 4-day adult
 
 5
Zinc 5 mM 12 hrs, larvae L3
 
 16
Zinc 4.5 mM 48 hrs, 4-day adult
 
 8
Ethanol 2.5% 3 hrs, larvae L3
 
 7
Ethanol 5% 3 hrs, larvae L3
 
 15
Ethanol 10% 3 hrs, larvae L3
 
 17
Caffeine 1.5 mg/ml 4 hrs, larvae L3
 
 17
Caffeine 2.5 mg/ml 48 hrs, 4-day adult
 
 5
Caffeine 25 mg/ml 48 hrs, 4-day adult
 
 8
Paraquat 5 mM 48 hrs, 4-day adult
 
 8
Paraquat 10 mM 48 hrs, 4-day adult
 
 14
Rotenone 2 μg 12 hrs, larvae L3
 
 14
Rotenone 8 μg 12 hrs, larvae L3
 
 15
Expression Level Scale
 Very low 
 Low 
 Moderate 
 Moderately high 
Linear, scaled to High expression
Treatment   Expression Level
extended cold, 4-day adult
 
 10
cold shock, 4-day adult
 
 9
heat shock, 4-day adult
 
 16
Cadmium 50 mM 6 hrs, larvae L3
 
 14
Cadmium 50 mM 12 hrs, larvae L3
 
 16
Cadmium 50 mM 48 hrs, 4-day adult
 
 24
Cadmium 100 mM 48 hrs, 4-day adult
 
 4
Copper 0.5 mM 12 hrs, larvae L3
 
 18
Copper 15 mM 48 hrs, 4-day adult
 
 5
Zinc 5 mM 12 hrs, larvae L3
 
 16
Zinc 4.5 mM 48 hrs, 4-day adult
 
 8
Ethanol 2.5% 3 hrs, larvae L3
 
 7
Ethanol 5% 3 hrs, larvae L3
 
 15
Ethanol 10% 3 hrs, larvae L3
 
 17
Caffeine 1.5 mg/ml 4 hrs, larvae L3
 
 17
Caffeine 2.5 mg/ml 48 hrs, 4-day adult
 
 5
Caffeine 25 mg/ml 48 hrs, 4-day adult
 
 8
Paraquat 5 mM 48 hrs, 4-day adult
 
 8
Paraquat 10 mM 48 hrs, 4-day adult
 
 14
Rotenone 2 μg 12 hrs, larvae L3
 
 14
Rotenone 8 μg 12 hrs, larvae L3
 
 15
Expression Level Scale
 Very low 
 Low 
 Moderate 
 Moderately high 
 High 
 Very high 
Linear, scaled to Extremely high expression
Treatment   Expression Level
extended cold, 4-day adult
 
 10
cold shock, 4-day adult
 
 9
heat shock, 4-day adult
 
 16
Cadmium 50 mM 6 hrs, larvae L3
 
 14
Cadmium 50 mM 12 hrs, larvae L3
 
 16
Cadmium 50 mM 48 hrs, 4-day adult
 
 24
Cadmium 100 mM 48 hrs, 4-day adult
 
 4
Copper 0.5 mM 12 hrs, larvae L3
 
 18
Copper 15 mM 48 hrs, 4-day adult
 
 5
Zinc 5 mM 12 hrs, larvae L3
 
 16
Zinc 4.5 mM 48 hrs, 4-day adult
 
 8
Ethanol 2.5% 3 hrs, larvae L3
 
 7
Ethanol 5% 3 hrs, larvae L3
 
 15
Ethanol 10% 3 hrs, larvae L3
 
 17
Caffeine 1.5 mg/ml 4 hrs, larvae L3
 
 17
Caffeine 2.5 mg/ml 48 hrs, 4-day adult
 
 5
Caffeine 25 mg/ml 48 hrs, 4-day adult
 
 8
Paraquat 5 mM 48 hrs, 4-day adult
 
 8
Paraquat 10 mM 48 hrs, 4-day adult
 
 14
Rotenone 2 μg 12 hrs, larvae L3
 
 14
Rotenone 8 μg 12 hrs, larvae L3
 
 15
Expression Level Scale
 Extremely high 
log, scaled to maximum expression level
Treatment   Expression Level
extended cold, 4-day adult
 
 10
cold shock, 4-day adult
 
 9
heat shock, 4-day adult
 
 16
Cadmium 50 mM 6 hrs, larvae L3
 
 14
Cadmium 50 mM 12 hrs, larvae L3
 
 16
Cadmium 50 mM 48 hrs, 4-day adult
 
 24
Cadmium 100 mM 48 hrs, 4-day adult
 
 4
Copper 0.5 mM 12 hrs, larvae L3
 
 18
Copper 15 mM 48 hrs, 4-day adult
 
 5
Zinc 5 mM 12 hrs, larvae L3
 
 16
Zinc 4.5 mM 48 hrs, 4-day adult
 
 8
Ethanol 2.5% 3 hrs, larvae L3
 
 7
Ethanol 5% 3 hrs, larvae L3
 
 15
Ethanol 10% 3 hrs, larvae L3
 
 17
Caffeine 1.5 mg/ml 4 hrs, larvae L3
 
 17
Caffeine 2.5 mg/ml 48 hrs, 4-day adult
 
 5
Caffeine 25 mg/ml 48 hrs, 4-day adult
 
 8
Paraquat 5 mM 48 hrs, 4-day adult
 
 8
Paraquat 10 mM 48 hrs, 4-day adult
 
 14
Rotenone 2 μg 12 hrs, larvae L3
 
 14
Rotenone 8 μg 12 hrs, larvae L3
 
 15
Expression Level Scale
 Very low 
 Low 
 Moderate 
 Moderately high 
log, scaled to Moderate expression
Treatment   Expression Level
extended cold, 4-day adult
 
 10
cold shock, 4-day adult
 
 9
heat shock, 4-day adult
 
 16
Cadmium 50 mM 6 hrs, larvae L3
 
 14
Cadmium 50 mM 12 hrs, larvae L3
 
 16
Cadmium 50 mM 48 hrs, 4-day adult
 
 24
Cadmium 100 mM 48 hrs, 4-day adult
 
 4
Copper 0.5 mM 12 hrs, larvae L3
 
 18
Copper 15 mM 48 hrs, 4-day adult
 
 5
Zinc 5 mM 12 hrs, larvae L3
 
 16
Zinc 4.5 mM 48 hrs, 4-day adult
 
 8
Ethanol 2.5% 3 hrs, larvae L3
 
 7
Ethanol 5% 3 hrs, larvae L3
 
 15
Ethanol 10% 3 hrs, larvae L3
 
 17
Caffeine 1.5 mg/ml 4 hrs, larvae L3
 
 17
Caffeine 2.5 mg/ml 48 hrs, 4-day adult
 
 5
Caffeine 25 mg/ml 48 hrs, 4-day adult
 
 8
Paraquat 5 mM 48 hrs, 4-day adult
 
 8
Paraquat 10 mM 48 hrs, 4-day adult
 
 14
Rotenone 2 μg 12 hrs, larvae L3
 
 14
Rotenone 8 μg 12 hrs, larvae L3
 
 15
Expression Level Scale
 Very low 
 Low 
 Moderate 
 Moderately high 
log, scaled to High expression
Treatment   Expression Level
extended cold, 4-day adult
 
 10
cold shock, 4-day adult
 
 9
heat shock, 4-day adult
 
 16
Cadmium 50 mM 6 hrs, larvae L3
 
 14
Cadmium 50 mM 12 hrs, larvae L3
 
 16
Cadmium 50 mM 48 hrs, 4-day adult
 
 24
Cadmium 100 mM 48 hrs, 4-day adult
 
 4
Copper 0.5 mM 12 hrs, larvae L3
 
 18
Copper 15 mM 48 hrs, 4-day adult
 
 5
Zinc 5 mM 12 hrs, larvae L3
 
 16
Zinc 4.5 mM 48 hrs, 4-day adult
 
 8
Ethanol 2.5% 3 hrs, larvae L3
 
 7
Ethanol 5% 3 hrs, larvae L3
 
 15
Ethanol 10% 3 hrs, larvae L3
 
 17
Caffeine 1.5 mg/ml 4 hrs, larvae L3
 
 17
Caffeine 2.5 mg/ml 48 hrs, 4-day adult
 
 5
Caffeine 25 mg/ml 48 hrs, 4-day adult
 
 8
Paraquat 5 mM 48 hrs, 4-day adult
 
 8
Paraquat 10 mM 48 hrs, 4-day adult
 
 14
Rotenone 2 μg 12 hrs, larvae L3
 
 14
Rotenone 8 μg 12 hrs, larvae L3
 
 15
Expression Level Scale
 Very low 
 Low 
 Moderate 
 Moderately high 
 High 
 Very high 
log, scaled to Extremely high expression
Treatment   Expression Level
extended cold, 4-day adult
 
 10
cold shock, 4-day adult
 
 9
heat shock, 4-day adult
 
 16
Cadmium 50 mM 6 hrs, larvae L3
 
 14
Cadmium 50 mM 12 hrs, larvae L3
 
 16
Cadmium 50 mM 48 hrs, 4-day adult
 
 24
Cadmium 100 mM 48 hrs, 4-day adult
 
 4
Copper 0.5 mM 12 hrs, larvae L3
 
 18
Copper 15 mM 48 hrs, 4-day adult
 
 5
Zinc 5 mM 12 hrs, larvae L3
 
 16
Zinc 4.5 mM 48 hrs, 4-day adult
 
 8
Ethanol 2.5% 3 hrs, larvae L3
 
 7
Ethanol 5% 3 hrs, larvae L3
 
 15
Ethanol 10% 3 hrs, larvae L3
 
 17
Caffeine 1.5 mg/ml 4 hrs, larvae L3
 
 17
Caffeine 2.5 mg/ml 48 hrs, 4-day adult
 
 5
Caffeine 25 mg/ml 48 hrs, 4-day adult
 
 8
Paraquat 5 mM 48 hrs, 4-day adult
 
 8
Paraquat 10 mM 48 hrs, 4-day adult
 
 14
Rotenone 2 μg 12 hrs, larvae L3
 
 14
Rotenone 8 μg 12 hrs, larvae L3
 
 15
Expression Level Scale
 Very low 
 Low 
 Moderate 
 Moderately high 
 High 
 Very high 
 Extremely high 
Heatmap
Treatment   Expression Level
extended cold, 4-day adult
 
 
cold shock, 4-day adult
 
 
heat shock, 4-day adult
 
 
Cadmium 50 mM 6 hrs, larvae L3
 
 
Cadmium 50 mM 12 hrs, larvae L3
 
 
Cadmium 50 mM 48 hrs, 4-day adult
 
 
Cadmium 100 mM 48 hrs, 4-day adult
 
 
Copper 0.5 mM 12 hrs, larvae L3
 
 
Copper 15 mM 48 hrs, 4-day adult
 
 
Zinc 5 mM 12 hrs, larvae L3
 
 
Zinc 4.5 mM 48 hrs, 4-day adult
 
 
Ethanol 2.5% 3 hrs, larvae L3
 
 
Ethanol 5% 3 hrs, larvae L3
 
 
Ethanol 10% 3 hrs, larvae L3
 
 
Caffeine 1.5 mg/ml 4 hrs, larvae L3
 
 
Caffeine 2.5 mg/ml 48 hrs, 4-day adult
 
 
Caffeine 25 mg/ml 48 hrs, 4-day adult
 
 
Paraquat 5 mM 48 hrs, 4-day adult
 
 
Paraquat 10 mM 48 hrs, 4-day adult
 
 
Rotenone 2 μg 12 hrs, larvae L3
 
 
Rotenone 8 μg 12 hrs, larvae L3
 
 

hide Expression Clusters
A cluster of genes with similar mRNA expression dynamics across development.
hide External Data & Images
Linkouts
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
FlyExpress - Embryonic expression images (BDGP data)
hide Alleles & Phenotypes
hide Summary of Allele Phenotypes
Lethality
Allele
Other Phenotypes
Allele
Phenotype manifest in
Allele
anterior fascicle & synapse, with Scer\GAL4elav-C155
bouton & neuromuscular junction & embryo
embryonic/larval midgut & endoderm
eye photoreceptor cell & axon
muscle attachment site & basal lamina
hide Classical Alleles ( 25 )
For All Classical Alleles Show

Allele of LanAClassMutagenStocksKnown lesion
LanAf059271 --
LanAMB01129
1 --
LanAMI02491
1 --
LanAMI06740
1 --
LanAScim1 Yes
LanA9-32amorphic allele - genetic evidence, loss of function allele0 Yes
LanA160hypomorphic allele - genetic evidence0 --
LanA1
0 --
LanA216hypomorphic allele - genetic evidence0 --
LanA25hypomorphic allele - genetic evidence0 --
LanA3A1
0 --
LanA4A8
0 --
LanA6-26
0 --
LanA6-36loss of function allele0 Yes
LanA6A1
0 --
LanA6A52
0 --
LanA7-50 Yes
LanA81Lhypomorphic allele - genetic evidence0 --
LanAA6-36
0 --
LanABG011500 Yes
LanABG01662
0 --
LanAC01-190
0 Yes
LanAEP36780 Yes
LanAEP4400 --
LanAGS6075
0 --
hide Alleles Carried on Transgenic Constructs ( 5 )
For All Alleles Carried on Transgenic Constructs Show

Allele of LanAClassMutagenStocksKnown lesion
LanAGD60221 Yes
LanAJF029081 Yes
LanAdsRNA.cGa0 Yes
LanAL.hs0 Yes
LanAS.hs0 Yes
hide Aneuploid Aberrations
Disrupted in
hide Transgenic Constructs & Insertions
Transgenic Constructs
Type of construct
Name
Expression data
UAS construct
Insertions
Type of insertions
Name
Expression data
insertion of enhancer trap
insertion of enhancer trap binary system
hide Gene Ontology: Function, Process & Cellular Component ( 25 unique terms )
hide Terms Based on Experimental Evidence ( 15 terms )
Molecular Function ( 0 terms)
Biological Process
CV term
References
inferred from mutant phenotype
inferred from mutant phenotype
inferred from mutant phenotype
inferred from expression pattern
inferred from mutant phenotype
Cellular Component
CV term
References
inferred from direct assay
hide Terms Based on Predictions or Assertions ( 11 terms )
Molecular Function
CV term
References
inferred from electronic annotation with InterPro:IPR009254
Biological Process
CV term
References
Cellular Component
CV term
References
inferred from sequence or structural similarity
inferred from sequence or structural similarity with mouse Lama1
non-traceable author statement
hide Sequence Ontology: Class of Gene
hide Interactions & Pathways
hide Summary of Physical Interactions
protein-protein
Interacting group
Assay
References
experimental knowledge based
experimental knowledge based
experimental knowledge based
experimental knowledge based
hide Summary of Genetic Interactions
Interacts with
Please look at the allele data for full details of the genetic interactions
LanA allele
Gene
References
hide External Data
Linkouts
BioGRID - A database of protein and genetic interactions
DroID - A comprehensive database of gene and protein interactions.
InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets.
hide Orthologs
hide OrthoDB Orthologs (49) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
Drosophila inclusive ortholog search
Dipteran inclusive ortholog search
Insect inclusive ortholog search
Arthropod inclusive ortholog search
Metazoa inclusive ortholog search
hideOrthologs in Drosophila Species (EOG6FFDM3)
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila melanogaster
fruit fly 
 
 
Drosophila simulans
 
Y
 
Drosophila sechellia
 
Y
 
Drosophila erecta
 
Y
 
Drosophila yakuba
 
Y
 
Drosophila ananassae
 
Y
 
Drosophila pseudoobscura pseudoobscura
 
Y
 
Drosophila persimilis
 
Y
 
Drosophila willistoni
 
Y
 
Drosophila virilis
 
Y
 
Drosophila mojavensis
 
 
 
Drosophila grimshawi
 
Y
 
hideOrthologs in non-Drosophila Dipterans (EOG6QC1D8)
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Aedes aegypti
Yellow fever mosquito 
 
Anopheles gambiae
Malaria mosquito 
 
Culex quinquefasciatus
Southern house mosquito 
 
hideOrthologs in non-Dipteran Insects (EOG6PZH2D)
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Apis mellifera
Western honey bee 
Amel\GB41930
 
Apis mellifera
Western honey bee 
Amel\GB49929
 
Nasonia vitripennis
Parasitic wasp 
Nvit\Nasvi2EG014878
 
Nasonia vitripennis
Parasitic wasp 
Nvit\Nasvi2EG014880
 
Acromyrmex echinatior
Panamanian leafcutter ant 
Aech\AECH17527
 
Atta cephalotes
Leafcutter ant 
Acep\ACEP12946
 
Camponotus floridanus
Florida carpenter ant 
Cflo\CFLO12778
 
Harpegnathos saltator
Jerdons jumping ant 
Hsal\HSAL23376
 
Linepithema humile
Argentine ant 
Lhum\LH17687
 
Pogonomyrmex barbatus
Red harvester ant 
Pbar\PB18333
 
Solenopsis invicta
Red fire ant 
Sinv\SINV21821
 
Acyrthosiphon pisum
Pea aphid 
 
Bombyx mori
Silkmoth 
 
Pediculus humanus
Human body louse 
 
Pediculus humanus
Human body louse 
 
Tribolium castaneum
Red flour beetle 
 
Tribolium castaneum
Red flour beetle 
 
hideOrthologs in non-Insect Arthropods (EOG6TDZ10)
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Daphnia pulex
Water flea 
 
Ixodes scapularis
Deer tick 
 
Ixodes scapularis
Deer tick 
 
hideOrthologs in non-Arthropod Metazoa (EOG66TFT5)
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Caenorhabditis elegans
Nematode 
 
Strongylocentrotus purpuratus
Purple sea urchin 
 
Strongylocentrotus purpuratus
Purple sea urchin 
 
Strongylocentrotus purpuratus
Purple sea urchin 
 
Danio rerio
Zebrafish 
 
Xenopus tropicalis
Western clawed frog 
 
Xenopus tropicalis
Western clawed frog 
 
Gallus gallus
Domestic chicken 
 
Gallus gallus
Domestic chicken 
 
Mus musculus
House mouse 
 
Mus musculus
House mouse 
 
Rattus norvegicus
Norway rat 
 
Rattus norvegicus
Norway rat 
 
Homo sapiens
Human 
 
hide Human Orthologs (1)
Gene
OMIM
HGNC
hideAAA Orthologs (10) based on analysis using Dmel annotation version 4.3
Organism
Gene
Drosophila simulans
Drosophila sechellia
Drosophila erecta
Drosophila yakuba
Drosophila ananassae
Drosophila pseudoobscura pseudoobscura
Drosophila persimilis
Drosophila willistoni
Drosophila virilis
Drosophila grimshawi
hide Stocks & Reagents
hide Stocks Listed in FlyBase ( 7 )
Bloomington
Harvard
VDRC
hide Genomic Clones ( 1 )
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
hide cDNA Clones ( 113 )
Please Note
This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones
Other clones
hide RNAi & Array Information
Linkouts
DRSC - Results from RNAi screens.
GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents
hide Antibody Information
hide Other Information
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hide Etymology
hide Identification
hide Relationship to Other Genes
Source for database identity of
Source for identity of: LanA CG10236
Source for database merge of
Additional comments
hide Other Comments
dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology.
LanA is not required for heart morphogenesis, but does play a role in the maintenance of the heart's ultrastructure.
In a sample of 79 genes with multiple introns, 33 showed significant heterogeneity in G+C content among introns of the same gene and significant positive correspondence between the intron and the third codon position G+C content within genes. These results are consistent with selection adding against preferred codons at the start of genes.
Identified in a screen for modifiers of the Dfd13/Dfd3 mutant phenotype. Shows no interaction with the Pc mutant phenotype.
Chain-specific polyclonal antibodies reveal that LanB1 and LanB2 form a stable dimer before they are disulfide-bonded to each other. LanA associates with neither monomeric LanB1, monomeric LanB2 nor LanB1 LanB2 dimer without disulfide-bonding but only with disulfide-bonded LanB1 LanB2 dimer to form LanA LanB1 LanB2 trimers. Results demonstrate that the interchain disulfide-bonding between LanB1 and LanB2 is essential for LanA LanB1 LanB2 trimer formation.
LanA demonstrates evolutionary conservation of binding properties similar to mammalian laminin. LanA binds mammalian nidogen and perlecan, similar proteins may exist in Drosophila.
Extracellular matrix containing LanA gene product is required for ocellar axon pathfinding.
Cell attachment activities of LanA peptides suggest that active regions in the G domain play an important role in cell surface receptor interactions.
Examination of mutant embryos and the function of Msp-300 during embryonic muscle development suggests a functional link between LanA and Msp-300 in the development of the embryonic somatic musculature.
Mutations of LanA show striking abnormalities in growth cone guidance of ocellar pioneer (OP) axons.
Mutations of LanA interact with Dfd to reduce the viability of the Dfd3/Dfd13 combination.
LanA function is not required for the early phases of mesoderm patterning and morphogenesis in embryos at the extended germ band stage. Function is required for the proper morphogenesis of the heart, somatic mesoderm and gut during later stages of embryonic development. The endoderm fails to undergo the initial columnar polarisation in the absence of functional LanA. These results indicate that the primary function of LanA is to provide structural support for the various cell types, enabling their proper organisation into the various organs.
Lack of LanA causes derangement in the patterning of the somatic muscles.
Clonal analysis revealed that the gene product functions in a non-cell autonomous fashion.
The LanA gene product is required for diverse functions during morphogenesis.
LanA gene cloned and expression pattern studied: changes in expression precede those of Cg25C.
The three Laminin genes (LanA, LanB1 and LanB2) encode the three subunits of Drosophila laminin, which associate to form a cruciform molecule in which the carboxy-terminal ends are α helical and associate with one another and whose amino-terminal ends are free to form three short arms of the cross.
The three Laminin genes (LanA, LanB1 and LanB2) encode the three subunits of laminin, a substrate adhesion molecule shown to be a potent promoter of neurite outgrowth.
hide External Crossreferences & Linkouts
Sequence Crossreferences
RefSeq (Transcripts)
RefSeq (Proteins)
Entrez Gene - A searchable database of RefSeq genes.
Other Crossreferences
InterPro domains - A database of protein families, domains, and functional sites
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
Linkouts
BioGRID - A database of protein and genetic interactions
DroID - A comprehensive database of gene and protein interactions.
DRSC - Results from RNAi screens.
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans
GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents
Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets.
modMine - Data generated by the modENCODE project.
hide Synonyms & Secondary IDs ( 31 )
Reported As
Symbol Synonym
FBtr0077014
laminin α3/5
Name Synonym
Laminin α3,5
laminin α3,5
laminin α-chain
α3,5 laminin
Secondary FlyBase IDs
  • FBgn0015948
hide References ( 189 )
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hide Recent research papers ( 10 )
Han et al., 2012, Neuron 73(1): 64--78
Integrins Regulate Repulsion-Mediated Dendritic Patterning of Drosophila Sensory Neurons by Restricting Dendrites in a 2D Space. [FBrf0217239]
Howell et al., 2012, Immunogenetics 64(2): 155--161
A directed miniscreen for genes involved in the Drosophila anti-parasitoid immune response. [FBrf0217123]
Koper et al., 2012, PLoS ONE 7(4): e36339
Analysis of Adhesion Molecules and Basement Membrane Contributions to Synaptic Adhesion at the Drosophila Embryonic NMJ. [FBrf0218212]
Li et al., 2012, Cell Rep. 1(1): 69--82
Global analysis of RNA secondary structure in two metazoans. [FBrf0219052]
Tsai et al., 2012, Proc. Natl. Acad. Sci. U.S.A. 109(43): 17699--17704
Activity-dependent retrograde laminin A signaling regulates synapse growth at Drosophila neuromuscular junctions. [FBrf0219768]
Vanderploeg et al., 2012, BMC Dev. Biol. 12: 8
Integrins are required for cardioblast polarisation in Drosophila. [FBrf0217831]
Baycin-Hizal et al., 2011, J. Proteome Res. 10(6): 2777--2784
GlycoFly: A Database of Drosophila N-linked Glycoproteins Identified Using SPEG-MS Techniques. [FBrf0213834]
Carreira et al., 2011, BMC Dev. Biol. 11: 32
Genetic basis of wing morphogenesis in Drosophila: sexual dimorphism and non-allometric effects of shape variation. [FBrf0214273]
Urbano et al., 2011, PLoS ONE 6(9): e23893
PS Integrins and Laminins: Key Regulators of Cell Migration during Drosophila Embryogenesis. [FBrf0216260]
Zwarts et al., 2011, Proc. Natl. Acad. Sci. U.S.A. 108(41): 17070--17075
Complex genetic architecture of Drosophila aggressive behavior. [FBrf0216413]
hide Recent reviews ( 2 )
Kaushik et al., 2012, J. Cell. Mol. Med. 16(8): 1656--1662
Measuring passive myocardial stiffness in Drosophila melanogaster to investigate diastolic dysfunction. [FBrf0219008]
Broadie et al., 2011, Dev. Neurobiol. 71(11): 1102--1130
Extracellular matrix and its receptors in drosophila neural development. [FBrf0216377]