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Gene Dmel\LanA

General Information
Symbol	Dmel\LanA	Species	D. melanogaster
Name	Laminin A	Annotation symbol	CG10236
Feature type	protein_coding_gene	FlyBase ID	FBgn0002526
Gene Model Status	Current	Stock availability	7 publicly available
Also Known As	lamA, Lan, Lam
Genomic Location
Chromosome (arm)	3L	Recombination map
Cytogenetic map	65A8-65A9	Sequence location	3L:6,196,931..6,211,122 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Laminin A is referred to in FlyBase by the symbol Dmel\LanA (CG10236, FBgn0002526). It is a protein_coding_gene from Drosophila melanogaster. An electronic pipeline based on InterPro domains suggests that it has the molecular function: receptor binding. There is experimental evidence for 12 unique biological process terms, many of which group under: single-organism developmental process; system development; post-embryonic organ morphogenesis; immune response; growth; locomotory behavior; cell cycle; cellular component organization or biogenesis; neuromuscular process; biological regulation. 30 alleles are reported. The phenotypes of these alleles are annotated with: organ system subdivision; organ system; peripheral nervous system; external compound sense organ; adult segment; non-connected developing system; adult; extracellular matrix; adult trachea; late extended germ band embryo. It has one annotated transcript and one annotated polypeptide. Protein features are: Concanavalin A-like lectin/glucanase, subgroup; Concanavalin A-like lectin/glucanases superfamily; EGF-like, conserved site; EGF-like, laminin; Laminin B type IV; Laminin B, subgroup; Laminin G domain; Laminin I; Laminin II; Laminin, N-terminal. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of low expression. Peak expression observed within 06-24 hour embryonic stages. Summary of FlyAtlas Anatomical Expression Data: Many larval and adult organs/tissues expressed at moderate or high levels. Expression at high levels in the following post-embryonic organs or tissues: larval hindgut, adult heart, larval fat body. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, larval/adult central nervous system, adult crop, larval/adult midgut, adult hindgut, larval Malpighian tubules, adult fat body, larval salivary gland, larval trachea, adult ovary, adult male accessory gland, larval/adult carcass. Comments on Affy2 ProbeSet: ProbeSet 1641324_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of LanA. Gene sequence location is 3L:6196931..6211122.
User Contributed Data
	Beta version, feedback welcome
External Summaries
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 65A8-65A9   Limits computationally determined from genome sequence between P{PZ}l(3)0209402094 and P{lacW}l(3)L4060L4060
Experimentally Determined Cytological Location
Cytogenetic map Notes References 65A-65A     (Gellon et al., 1997) 64C-65C   (determined by in situ hybridisation)   (Harding et al., 1995) 65A-65A   (determined by in situ hybridisation)   (Garrison and Fessler, 1990) 65A10-65A11   (determined by in situ hybridisation)   (Kusche-Gullberg et al., 1992) 65A10-65A11   (determined by in situ hybridisation)   (Montell and Goodman, 1988)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\LanA for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.45 Low-frequency RNA-seq exon junction(s) not annotated.
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) LanA-RA FBtr0077014  NM_057269   11690   3712
Additional Transcript Data & Comments
Reported size (kB)	11.5 (compiled cDNA) (Henchcliffe et al., 1993) 11.0 (northern blot) (Montell and Goodman, 1988)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein LanA-PA   FBpp0076722   411.1   3712   4.85     NP_476617   AAF50672
Additional Polypeptide Data & Comments
Reported size (kDa)	3712 (aa); 409 (kD) (Kusche-Gullberg et al., 1992) 3712 (aa) (Henchcliffe et al., 1993) 400 (kD observed) (Montell and Goodman, 1988)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Laminin B, subgroup (IPR018031) Laminin B type IV (IPR000034) Laminin G domain (IPR001791) EGF-like, laminin (IPR002049) Laminin, N-terminal (IPR008211) Concanavalin A-like lectin/glucanases superfamily (IPR008985) Laminin I (IPR009254) Laminin II (IPR010307) EGF-like, conserved site (IPR013032) Concanavalin A-like lectin/glucanase, subgroup (IPR013320)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA802263   AA820209   AA820583   AE014296 AAF50672   AC004357   AC004767   AI258183   AI296566   AI516890   AI530984   AI531192   AI533433   AI534172   AI534194   AI534266   AI534327   AI542715   AI542719   AI543656   AI544360   AQ025086   AQ073113   AW942703   BG636268   BG636458   BG638378   BG639259   BG639824   BG640932   BI355668   BI355669   BI564082   BI564644   BI583519   BI590868   BI628696   BI633230   BI634091   BI635603   BI635849   BI637352   BI638669   BI639155   BI639203   BI639331   BI639744   BI640145   BI640444   BI641125   BI641408   BI641647   BI641810   BI641962   BP549510   BP557603   BT032866   CK659173   CK661440   CO153058   CO153119   CO153225   CO153665   CO154785   CO183869   CO187124   CO187683   CO189693   CO194177   CO275265   CO280248   CO285292   CO290336   CO296092   CO302820   CO306811   CO307846   CO309867   CO310919   CO318092   CO318132   CO323621   CO327440   CO327816   CO329139   CO337074   CO338500   CZ488559   EC056987   EC057919   EC066736   EC080396   EC085528   EC087599   EC196433   EC199332   EC203663   EC205652   EC206583   EC211848   EC213326   EC216146   EC226293   EC229967   EC236193   EC238749   EC243300   EC249016   EC256867   EC258103   EC263679   EC265152   EC266234   EC267259   GH945894   GH945932   GH949797   GH950646   GH952308   GH954687   GH957617   GH961356   GH963349   GH965543   GH966917   L07288 AAC37178   M75882 AAA28661   M96388 AAA28662
UniProtKB/Swiss-Prot	Q00174
UniProtKB/TrEMBL
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
No Assay Recorded Stage Tissue/Position (including subcellular localization) Reference embryonic stage | late   sense organ   • basal lamina (Kusche-Gullberg et al., 1992) embryonic brain   • basal lamina (Kusche-Gullberg et al., 1992) embryonic stage 11 -- 12   head mesoderm   (Kusche-Gullberg et al., 1992) embryonic stage 13 -- 17   glial cell | lateral   (Kusche-Gullberg et al., 1992) in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage | late   embryonic/larval midgut   • basal lamina (Kusche-Gullberg et al., 1992) ventral nerve cord   • basal lamina (Kusche-Gullberg et al., 1992) embryonic stage 4 -- 6   anterior endoderm anlage   (Fisher et al., 2012) Comment:anlage in statu nascendi endoderm anlage   (Fisher et al., 2012) Comment:anlage in statu nascendi posterior ectoderm anlage   (Fisher et al., 2012) Comment:anlage in statu nascendi embryonic stage 7 -- 8   anterior endoderm anlage   (Fisher et al., 2012) posterior endoderm   (Fisher et al., 2012) embryonic stage 9 -- 10   amnioserosa primordium   (Fisher et al., 2012) anterior endoderm   (Fisher et al., 2012) head mesoderm   (Fisher et al., 2012) posterior endoderm   (Fisher et al., 2012) trunk mesoderm   (Fisher et al., 2012) embryonic stage 11 -- 12   amnioserosa   (Fisher et al., 2012) anterior midgut primordium   (Fisher et al., 2012) dorsal epidermis primordium   (Fisher et al., 2012) dorsal head epidermis primordium   (Fisher et al., 2012) Comment:reported as head epidermis primordium lateral head epidermis primordium   (Fisher et al., 2012) Comment:reported as head epidermis primordium ventral head epidermis primordium   (Fisher et al., 2012) Comment:reported as head epidermis primordium foregut primordium   (Fisher et al., 2012) head mesoderm   (Fisher et al., 2012) hindgut proper primordium   (Fisher et al., 2012) posterior midgut primordium   (Fisher et al., 2012) tracheal primordium   (Fisher et al., 2012) trunk mesoderm   (Fisher et al., 2012) ventral epidermis primordium   (Fisher et al., 2012) embryonic stage 13 -- 16   embryonic dorsal epidermis   (Fisher et al., 2012) embryonic foregut   (Fisher et al., 2012) embryonic head epidermis   (Fisher et al., 2012) embryonic hindgut   (Fisher et al., 2012) embryonic ventral epidermis   (Fisher et al., 2012) embryonic/larval midgut   (Fisher et al., 2012) plasmatocyte   (Fisher et al., 2012) embryonic stage 13 -- 17   embryonic/larval fat body   (Kusche-Gullberg et al., 1992) hemocyte   (Kusche-Gullberg et al., 1992) radioisotope in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage   visceral mesoderm   (Montell and Goodman, 1989) somatic mesoderm   (Montell and Goodman, 1989) ventral midline   (Montell and Goodman, 1989) ectoderm   (Montell and Goodman, 1989) interface glial cell   (Montell and Goodman, 1989)
Additional Descriptive Data
	LanA transcripts are expressed through most of embryogenesis with a peak in 6-9hr embryos. (Montell and Goodman, 1988) LanA transcripts are detected in 4-6hr embryos, peak at 10-12hr, and then decline. Later peaks occur in early larvae, and late pupae. Developmental increases in Laminin transcripts are associated with periods of morphogenesis and precede those of Cg25C transcripts. Laminin transcripts appear in newly formed mesoderm and are later expressed in fat body, in some glial cells and prominantly in hemocytes found distributed around many organs where basement membrane deposition occurs such as brain, nerve cord, sensory organs, and various internal organs. LanA transcripts are detected at a lower level than LanB1 and LanB2 transcripts. (Kusche-Gullberg et al., 1992) LanA expression is first detected during germ band extension in the mesoderm and at lower levels in the ectoderm including the neurogenic region. At ~8hr, the level of LanA expression dramatically increases in both the somatic and visceral mesoderm and expression in these tissues continues through the rest of embryonic development. At 8hr, expression in the ectoderm also increases but mainly in the epidermis and not in ectodermal derivatives such as the salivary glands and the CNS. The only LanA expression in the CNS is found along the midline. The interface glia were also tentatively identified as a site of LanA expression. The patterns of expression of LanA, LanB1, and LanB2 are nearly identical. (Montell and Goodman, 1989)
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
No Assay Recorded Stage Tissue/Position (including subcellular localization) Reference embryonic stage   embryonic brain   • basal lamina (Kusche-Gullberg et al., 1992) hemocyte   (Kusche-Gullberg et al., 1992) embryonic/larval muscle system   • basal lamina (Kusche-Gullberg et al., 1992) glial cell   (Kusche-Gullberg et al., 1992) immunolocalization Stage Tissue/Position (including subcellular localization) Reference embryonic stage   embryonic/larval midgut primordium   • basal lamina (Kusche-Gullberg et al., 1992) primordium of embryonic/larval spiracle   • basal lamina (Kusche-Gullberg et al., 1992) ventral nerve cord   • basal lamina (Kusche-Gullberg et al., 1992) embryonic/larval fat body   (Kusche-Gullberg et al., 1992) embryonic stage 13 -- 15   embryonic/larval digestive system   (Montell and Goodman, 1989) Comment:reference states 10-13 hr AEL epidermis   (Montell and Goodman, 1989) Comment:reference states 10-13 hr AEL myoblast of embryonic/larval muscle system   (Montell and Goodman, 1989) Comment:reference states 10-13 hr AEL segmental nerve   (Montell and Goodman, 1989) Comment:10-13 hr AEL intersegmental nerve   (Montell and Goodman, 1989) Comment:10-13 hr AEL neuropil associated CNS glial cell   (Montell and Goodman, 1989) Comment:10-13 hr AEL mass spectroscopy Stage Tissue/Position (including subcellular localization) Reference day 7 of adulthood -- day 49 of adulthood   adult heart   (Cammarato et al., 2011) western blot Stage Tissue/Position (including subcellular localization) Reference   Kc167 cell-line   (Kumagai et al., 2000) Comment:in conditioned medium
Additional Descriptive Data
	In dissected embryos between 10-13 hours of development, LanA is detected in basement membrane throughout the embryo. These include basement membranes covering the inside of the epidermis, developing muscles, gut, and internal glands and organs. LanA is also detected in the dorsal basement membrane overlying the developing CNS and in a prominent pair of mesodermal cells just dorsal to the nervous system. The most striking staining in the developing CNS is seen along the axon pathways, including the longitudinal pathways, the commissural pathways, and the peripheral nerve roots. The glia around the peripheral nerve roots also stain. Staining is also observed surrounding clusters of peripheral sensory organs and their support cells. All three Laminin subunits show similar patterns of staining. (Montell and Goodman, 1989) LanA protein is detected in embryonic hemocytes and fat body. In later embryos, LanA protein is observed in basement membranes surrounding the nerve cord, brain, gut, spiracles, sensory bodies, and muscles. (Kusche-Gullberg et al., 1992)
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
basal lamina inferred from direct assay (Fessler et al., 1994) basement membrane inferred from direct assay (Kusche-Gullberg et al., 1992) presynaptic periactive zone inferred from direct assay (Tsai et al., 2012)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Many larval and adult organs/tissues expressed at moderate or high levels. Expression at high levels in the following post-embryonic organs or tissues: larval hindgut, adult heart, larval fat body. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, larval/adult central nervous system, adult crop, larval/adult midgut, adult hindgut, larval Malpighian tubules, adult fat body, larval salivary gland, larval trachea, adult ovary, adult male accessory gland, larval/adult carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    306.25 Larval Midgut    156.7 Larval Hindgut    1476.4 Larval Malpighian Tubules    376.8 Larval Fat Body    1076.5 Larval Salivary Gland    106.7 Larval Trachea    434.4 Larval Carcass    491.25 Adult Head    132.8 Adult Eye    29.475 Adult Brain    79.2 Adult Thoracic-Abdominal Ganglion    179.1 Adult Crop    375.4 Adult Midgut    118.3 Adult Hindgut    187.7 Adult Malpighian Tubules    98.6 Adult Fat Body    108.7 Adult Salivary Gland    18.8 Adult Heart    656.475 Adult VirginFemale Spermatheca    37.2 Adult InseminatedFemale Spermatheca    59.8 Adult Ovary    199.3 Adult Testis    61.5 Adult Male Accessory Gland    305.4 Adult Carcass    172 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    306.25 Larval Midgut    156.7 Larval Hindgut  (1476.4) Larval Malpighian Tubules    376.8 Larval Fat Body  (1076.5) Larval Salivary Gland    106.7 Larval Trachea    434.4 Larval Carcass    491.25 Adult Head    132.8 Adult Eye    29.475 Adult Brain    79.2 Adult Thoracic-Abdominal Ganglion    179.1 Adult Crop    375.4 Adult Midgut    118.3 Adult Hindgut    187.7 Adult Malpighian Tubules    98.6 Adult Fat Body    108.7 Adult Salivary Gland    18.8 Adult Heart  (656.475) Adult VirginFemale Spermatheca    37.2 Adult InseminatedFemale Spermatheca    59.8 Adult Ovary    199.3 Adult Testis    61.5 Adult Male Accessory Gland    305.4 Adult Carcass    172 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    306.25 Larval Midgut    156.7 Larval Hindgut  (1476.4) Larval Malpighian Tubules    376.8 Larval Fat Body  1076.5 Larval Salivary Gland    106.7 Larval Trachea    434.4 Larval Carcass    491.25 Adult Head    132.8 Adult Eye    29.475 Adult Brain    79.2 Adult Thoracic-Abdominal Ganglion    179.1 Adult Crop    375.4 Adult Midgut    118.3 Adult Hindgut    187.7 Adult Malpighian Tubules    98.6 Adult Fat Body    108.7 Adult Salivary Gland    18.8 Adult Heart    656.475 Adult VirginFemale Spermatheca    37.2 Adult InseminatedFemale Spermatheca    59.8 Adult Ovary    199.3 Adult Testis    61.5 Adult Male Accessory Gland    305.4 Adult Carcass    172 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    306.25 Larval Midgut    156.7 Larval Hindgut    1476.4 Larval Malpighian Tubules    376.8 Larval Fat Body    1076.5 Larval Salivary Gland    106.7 Larval Trachea    434.4 Larval Carcass    491.25 Adult Head    132.8 Adult Eye    29.475 Adult Brain    79.2 Adult Thoracic-Abdominal Ganglion    179.1 Adult Crop    375.4 Adult Midgut    118.3 Adult Hindgut    187.7 Adult Malpighian Tubules    98.6 Adult Fat Body    108.7 Adult Salivary Gland    18.8 Adult Heart    656.475 Adult VirginFemale Spermatheca    37.2 Adult InseminatedFemale Spermatheca    59.8 Adult Ovary    199.3 Adult Testis    61.5 Adult Male Accessory Gland    305.4 Adult Carcass    172 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    306.25 Larval Midgut    156.7 Larval Hindgut    1476.4 Larval Malpighian Tubules    376.8 Larval Fat Body    1076.5 Larval Salivary Gland    106.7 Larval Trachea    434.4 Larval Carcass    491.25 Adult Head    132.8 Adult Eye    29.475 Adult Brain    79.2 Adult Thoracic-Abdominal Ganglion    179.1 Adult Crop    375.4 Adult Midgut    118.3 Adult Hindgut    187.7 Adult Malpighian Tubules    98.6 Adult Fat Body    108.7 Adult Salivary Gland    18.8 Adult Heart    656.475 Adult VirginFemale Spermatheca    37.2 Adult InseminatedFemale Spermatheca    59.8 Adult Ovary    199.3 Adult Testis    61.5 Adult Male Accessory Gland    305.4 Adult Carcass    172 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    306.25 Larval Midgut    156.7 Larval Hindgut  (1476.4) Larval Malpighian Tubules    376.8 Larval Fat Body  (1076.5) Larval Salivary Gland    106.7 Larval Trachea    434.4 Larval Carcass    491.25 Adult Head    132.8 Adult Eye    29.475 Adult Brain    79.2 Adult Thoracic-Abdominal Ganglion    179.1 Adult Crop    375.4 Adult Midgut    118.3 Adult Hindgut    187.7 Adult Malpighian Tubules    98.6 Adult Fat Body    108.7 Adult Salivary Gland    18.8 Adult Heart  656.475 Adult VirginFemale Spermatheca    37.2 Adult InseminatedFemale Spermatheca    59.8 Adult Ovary    199.3 Adult Testis    61.5 Adult Male Accessory Gland    305.4 Adult Carcass    172 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    306.25 Larval Midgut    156.7 Larval Hindgut  1476.4 Larval Malpighian Tubules    376.8 Larval Fat Body  1076.5 Larval Salivary Gland    106.7 Larval Trachea    434.4 Larval Carcass    491.25 Adult Head    132.8 Adult Eye    29.475 Adult Brain    79.2 Adult Thoracic-Abdominal Ganglion    179.1 Adult Crop    375.4 Adult Midgut    118.3 Adult Hindgut    187.7 Adult Malpighian Tubules    98.6 Adult Fat Body    108.7 Adult Salivary Gland    18.8 Adult Heart    656.475 Adult VirginFemale Spermatheca    37.2 Adult InseminatedFemale Spermatheca    59.8 Adult Ovary    199.3 Adult Testis    61.5 Adult Male Accessory Gland    305.4 Adult Carcass    172 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    306.25 Larval Midgut    156.7 Larval Hindgut    1476.4 Larval Malpighian Tubules    376.8 Larval Fat Body    1076.5 Larval Salivary Gland    106.7 Larval Trachea    434.4 Larval Carcass    491.25 Adult Head    132.8 Adult Eye    29.475 Adult Brain    79.2 Adult Thoracic-Abdominal Ganglion    179.1 Adult Crop    375.4 Adult Midgut    118.3 Adult Hindgut    187.7 Adult Malpighian Tubules    98.6 Adult Fat Body    108.7 Adult Salivary Gland    18.8 Adult Heart    656.475 Adult VirginFemale Spermatheca    37.2 Adult InseminatedFemale Spermatheca    59.8 Adult Ovary    199.3 Adult Testis    61.5 Adult Male Accessory Gland    305.4 Adult Carcass    172 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    132.8   NA  Eye    29.475   NA  Brain    79.2   306.25  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    179.1   NA  Crop    375.4   156.7  Midgut    118.3   1476.4  Hindgut    187.7   376.8  Malpighian Tubules    98.6   1076.5  Fat Body    108.7   106.7  Salivary Gland    no informative data   NA  Heart    656.475   434.4  Trachea    NA   NA  VirginFemale Spermatheca    37.2   NA  InseminatedFemale Spermatheca    59.8   NA  Ovary    199.3   NA  Testis    61.5   NA  Male Accessory Gland    305.4   491.25  Carcass    172 FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    38 central nervous system, larvae L3    16 central nervous system, pupae P8    13 head, virgin 1-day female    18 head, virgin 4-day female    6 head, virgin 20-day female    6 head, mated 1-day female    11 head, mated 4-day female    8 head, mated 20-day female    6 head, mated 1-day male    8 head, mated 4-day male    8 head, mated 20-day male    7 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    17 digestive system, larvae L3 wandering    9 digestive system, 1-day adult    4 digestive system, 4-day adult    5 digestive system, 20-day adult    3 fat body, larvae L3 wandering    55 fat body, white prepupae    62 fat body, pupae P8    65 carcass, larvae L3 wandering    41 carcass, 1-day adult    10 carcass, 4-day adult    6 carcass, 20-day adult    4 ovary, virgin 4-day female    8 ovary, mated 4-day female    7 testis, mated 4-day male    1 accessory gland, mated 4-day male    3 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (38) central nervous system, larvae L3    16 central nervous system, pupae P8    13 head, virgin 1-day female    18 head, virgin 4-day female    6 head, virgin 20-day female    6 head, mated 1-day female    11 head, mated 4-day female    8 head, mated 20-day female    6 head, mated 1-day male    8 head, mated 4-day male    8 head, mated 20-day male    7 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    17 digestive system, larvae L3 wandering    9 digestive system, 1-day adult    4 digestive system, 4-day adult    5 digestive system, 20-day adult    3 fat body, larvae L3 wandering  (55) fat body, white prepupae  (62) fat body, pupae P8  (65) carcass, larvae L3 wandering  (41) carcass, 1-day adult    10 carcass, 4-day adult    6 carcass, 20-day adult    4 ovary, virgin 4-day female    8 ovary, mated 4-day female    7 testis, mated 4-day male    1 accessory gland, mated 4-day male    3 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    38 central nervous system, larvae L3    16 central nervous system, pupae P8    13 head, virgin 1-day female    18 head, virgin 4-day female    6 head, virgin 20-day female    6 head, mated 1-day female    11 head, mated 4-day female    8 head, mated 20-day female    6 head, mated 1-day male    8 head, mated 4-day male    8 head, mated 20-day male    7 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    17 digestive system, larvae L3 wandering    9 digestive system, 1-day adult    4 digestive system, 4-day adult    5 digestive system, 20-day adult    3 fat body, larvae L3 wandering    55 fat body, white prepupae    62 fat body, pupae P8    65 carcass, larvae L3 wandering    41 carcass, 1-day adult    10 carcass, 4-day adult    6 carcass, 20-day adult    4 ovary, virgin 4-day female    8 ovary, mated 4-day female    7 testis, mated 4-day male    1 accessory gland, mated 4-day male    3 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    38 central nervous system, larvae L3    16 central nervous system, pupae P8    13 head, virgin 1-day female    18 head, virgin 4-day female    6 head, virgin 20-day female    6 head, mated 1-day female    11 head, mated 4-day female    8 head, mated 20-day female    6 head, mated 1-day male    8 head, mated 4-day male    8 head, mated 20-day male    7 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    17 digestive system, larvae L3 wandering    9 digestive system, 1-day adult    4 digestive system, 4-day adult    5 digestive system, 20-day adult    3 fat body, larvae L3 wandering    55 fat body, white prepupae    62 fat body, pupae P8    65 carcass, larvae L3 wandering    41 carcass, 1-day adult    10 carcass, 4-day adult    6 carcass, 20-day adult    4 ovary, virgin 4-day female    8 ovary, mated 4-day female    7 testis, mated 4-day male    1 accessory gland, mated 4-day male    3 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    38 central nervous system, larvae L3    16 central nervous system, pupae P8    13 head, virgin 1-day female    18 head, virgin 4-day female    6 head, virgin 20-day female    6 head, mated 1-day female    11 head, mated 4-day female    8 head, mated 20-day female    6 head, mated 1-day male    8 head, mated 4-day male    8 head, mated 20-day male    7 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    17 digestive system, larvae L3 wandering    9 digestive system, 1-day adult    4 digestive system, 4-day adult    5 digestive system, 20-day adult    3 fat body, larvae L3 wandering    55 fat body, white prepupae    62 fat body, pupae P8    65 carcass, larvae L3 wandering    41 carcass, 1-day adult    10 carcass, 4-day adult    6 carcass, 20-day adult    4 ovary, virgin 4-day female    8 ovary, mated 4-day female    7 testis, mated 4-day male    1 accessory gland, mated 4-day male    3 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (38) central nervous system, larvae L3    16 central nervous system, pupae P8    13 head, virgin 1-day female    18 head, virgin 4-day female    6 head, virgin 20-day female    6 head, mated 1-day female    11 head, mated 4-day female    8 head, mated 20-day female    6 head, mated 1-day male    8 head, mated 4-day male    8 head, mated 20-day male    7 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    17 digestive system, larvae L3 wandering    9 digestive system, 1-day adult    4 digestive system, 4-day adult    5 digestive system, 20-day adult    3 fat body, larvae L3 wandering  (55) fat body, white prepupae  (62) fat body, pupae P8  (65) carcass, larvae L3 wandering  (41) carcass, 1-day adult    10 carcass, 4-day adult    6 carcass, 20-day adult    4 ovary, virgin 4-day female    8 ovary, mated 4-day female    7 testis, mated 4-day male    1 accessory gland, mated 4-day male    3 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    38 central nervous system, larvae L3    16 central nervous system, pupae P8    13 head, virgin 1-day female    18 head, virgin 4-day female    6 head, virgin 20-day female    6 head, mated 1-day female    11 head, mated 4-day female    8 head, mated 20-day female    6 head, mated 1-day male    8 head, mated 4-day male    8 head, mated 20-day male    7 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    17 digestive system, larvae L3 wandering    9 digestive system, 1-day adult    4 digestive system, 4-day adult    5 digestive system, 20-day adult    3 fat body, larvae L3 wandering    55 fat body, white prepupae    62 fat body, pupae P8    65 carcass, larvae L3 wandering    41 carcass, 1-day adult    10 carcass, 4-day adult    6 carcass, 20-day adult    4 ovary, virgin 4-day female    8 ovary, mated 4-day female    7 testis, mated 4-day male    1 accessory gland, mated 4-day male    3 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    38 central nervous system, larvae L3    16 central nervous system, pupae P8    13 head, virgin 1-day female    18 head, virgin 4-day female    6 head, virgin 20-day female    6 head, mated 1-day female    11 head, mated 4-day female    8 head, mated 20-day female    6 head, mated 1-day male    8 head, mated 4-day male    8 head, mated 20-day male    7 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    17 digestive system, larvae L3 wandering    9 digestive system, 1-day adult    4 digestive system, 4-day adult    5 digestive system, 20-day adult    3 fat body, larvae L3 wandering    55 fat body, white prepupae    62 fat body, pupae P8    65 carcass, larvae L3 wandering    41 carcass, 1-day adult    10 carcass, 4-day adult    6 carcass, 20-day adult    4 ovary, virgin 4-day female    8 ovary, mated 4-day female    7 testis, mated 4-day male    1 accessory gland, mated 4-day male    3 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of low expression. Peak expression observed within 06-24 hour embryonic stages. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    2 embryo 02-04hr    15 embryo 04-06hr    59 embryo 06-08hr    182 embryo 08-10hr    219 embryo 10-12hr    147 embryo 12-14hr    282 embryo 14-16hr    314 embryo 16-18hr    245 embryo 18-20hr    146 embryo 20-22hr    66 embryo 22-24hr    77 larva L1    105 larva L2    110 larva L3 12hr old    62 larva L3 puffstage 1-2    30 larva L3 puffstage 3-6    51 larva L3 puffstage 7-9    54 white prepupae new    61 white prepupae 12hr    26 white prepupae 24hr    42 pupae 2d postWPP    39 pupae 3d postWPP    60 pupae 4d postWPP    20 adult male 01day    10 adult male 05day    6 adult male 30day    4 adult female 01day    24 adult female 05day    15 adult female 30day    13 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    2 embryo 02-04hr    15 embryo 04-06hr  (59) embryo 06-08hr  (182) embryo 08-10hr  (219) embryo 10-12hr  (147) embryo 12-14hr  (282) embryo 14-16hr  (314) embryo 16-18hr  (245) embryo 18-20hr  (146) embryo 20-22hr  (66) embryo 22-24hr  (77) larva L1  (105) larva L2  (110) larva L3 12hr old  (62) larva L3 puffstage 1-2  (30) larva L3 puffstage 3-6  (51) larva L3 puffstage 7-9  (54) white prepupae new  (61) white prepupae 12hr  26 white prepupae 24hr  (42) pupae 2d postWPP  (39) pupae 3d postWPP  (60) pupae 4d postWPP    20 adult male 01day    10 adult male 05day    6 adult male 30day    4 adult female 01day    24 adult female 05day    15 adult female 30day    13 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    2 embryo 02-04hr    15 embryo 04-06hr    59 embryo 06-08hr  (182) embryo 08-10hr  (219) embryo 10-12hr  (147) embryo 12-14hr  (282) embryo 14-16hr  (314) embryo 16-18hr  (245) embryo 18-20hr  (146) embryo 20-22hr    66 embryo 22-24hr    77 larva L1  105 larva L2  (110) larva L3 12hr old    62 larva L3 puffstage 1-2    30 larva L3 puffstage 3-6    51 larva L3 puffstage 7-9    54 white prepupae new    61 white prepupae 12hr    26 white prepupae 24hr    42 pupae 2d postWPP    39 pupae 3d postWPP    60 pupae 4d postWPP    20 adult male 01day    10 adult male 05day    6 adult male 30day    4 adult female 01day    24 adult female 05day    15 adult female 30day    13 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    2 embryo 02-04hr    15 embryo 04-06hr    59 embryo 06-08hr    182 embryo 08-10hr    219 embryo 10-12hr    147 embryo 12-14hr    282 embryo 14-16hr    314 embryo 16-18hr    245 embryo 18-20hr    146 embryo 20-22hr    66 embryo 22-24hr    77 larva L1    105 larva L2    110 larva L3 12hr old    62 larva L3 puffstage 1-2    30 larva L3 puffstage 3-6    51 larva L3 puffstage 7-9    54 white prepupae new    61 white prepupae 12hr    26 white prepupae 24hr    42 pupae 2d postWPP    39 pupae 3d postWPP    60 pupae 4d postWPP    20 adult male 01day    10 adult male 05day    6 adult male 30day    4 adult female 01day    24 adult female 05day    15 adult female 30day    13 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    2 embryo 02-04hr    15 embryo 04-06hr    59 embryo 06-08hr    182 embryo 08-10hr    219 embryo 10-12hr    147 embryo 12-14hr    282 embryo 14-16hr    314 embryo 16-18hr    245 embryo 18-20hr    146 embryo 20-22hr    66 embryo 22-24hr    77 larva L1    105 larva L2    110 larva L3 12hr old    62 larva L3 puffstage 1-2    30 larva L3 puffstage 3-6    51 larva L3 puffstage 7-9    54 white prepupae new    61 white prepupae 12hr    26 white prepupae 24hr    42 pupae 2d postWPP    39 pupae 3d postWPP    60 pupae 4d postWPP    20 adult male 01day    10 adult male 05day    6 adult male 30day    4 adult female 01day    24 adult female 05day    15 adult female 30day    13 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    2 embryo 02-04hr    15 embryo 04-06hr  (59) embryo 06-08hr  (182) embryo 08-10hr  (219) embryo 10-12hr  (147) embryo 12-14hr  (282) embryo 14-16hr  (314) embryo 16-18hr  (245) embryo 18-20hr  (146) embryo 20-22hr  (66) embryo 22-24hr  (77) larva L1  (105) larva L2  (110) larva L3 12hr old  (62) larva L3 puffstage 1-2  30 larva L3 puffstage 3-6  (51) larva L3 puffstage 7-9  (54) white prepupae new  (61) white prepupae 12hr  26 white prepupae 24hr  (42) pupae 2d postWPP  (39) pupae 3d postWPP  (60) pupae 4d postWPP    20 adult male 01day    10 adult male 05day    6 adult male 30day    4 adult female 01day    24 adult female 05day    15 adult female 30day    13 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    2 embryo 02-04hr    15 embryo 04-06hr    59 embryo 06-08hr  (182) embryo 08-10hr  (219) embryo 10-12hr  (147) embryo 12-14hr  (282) embryo 14-16hr  (314) embryo 16-18hr  (245) embryo 18-20hr  (146) embryo 20-22hr    66 embryo 22-24hr    77 larva L1  105 larva L2  110 larva L3 12hr old    62 larva L3 puffstage 1-2    30 larva L3 puffstage 3-6    51 larva L3 puffstage 7-9    54 white prepupae new    61 white prepupae 12hr    26 white prepupae 24hr    42 pupae 2d postWPP    39 pupae 3d postWPP    60 pupae 4d postWPP    20 adult male 01day    10 adult male 05day    6 adult male 30day    4 adult female 01day    24 adult female 05day    15 adult female 30day    13 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    2 embryo 02-04hr    15 embryo 04-06hr    59 embryo 06-08hr    182 embryo 08-10hr    219 embryo 10-12hr    147 embryo 12-14hr    282 embryo 14-16hr    314 embryo 16-18hr    245 embryo 18-20hr    146 embryo 20-22hr    66 embryo 22-24hr    77 larva L1    105 larva L2    110 larva L3 12hr old    62 larva L3 puffstage 1-2    30 larva L3 puffstage 3-6    51 larva L3 puffstage 7-9    54 white prepupae new    61 white prepupae 12hr    26 white prepupae 24hr    42 pupae 2d postWPP    39 pupae 3d postWPP    60 pupae 4d postWPP    20 adult male 01day    10 adult male 05day    6 adult male 30day    4 adult female 01day    24 adult female 05day    15 adult female 30day    13 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    400 Schneider line 2 Sg4    233 embryonic 1182-4H    812 embryonic GM2    157 embryonic Kc167    153 embryonic S1    233 embryonic S3    161 leg disc CME L1    430 wing disc CME-W2    453 wing disc ML-DmD8    193 wing disc ML-DmD9    375 wing disc ML-DmD16-c3    432 wing disc ML-DmD21    64 wing disc ML-DmD32    364 haltere disc ML-DmD17-c3    363 eye-antennal disc ML-DmD11    329 antennal disc ML-DmD20-c5    190 mixed discs ML-DmD4-c1    160 CNS ML-DmBG1-c1    175 CNS ML-DmBG2-c2    164 tumorous blood cells mbn2    263 ovary fGS/OSS    153 ovary OSC    132 ovary OSS    58 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (400) Schneider line 2 Sg4  (233) embryonic 1182-4H  (812) embryonic GM2  (157) embryonic Kc167  (153) embryonic S1  (233) embryonic S3  (161) leg disc CME L1  (430) wing disc CME-W2  (453) wing disc ML-DmD8  (193) wing disc ML-DmD9  (375) wing disc ML-DmD16-c3  (432) wing disc ML-DmD21  (64) wing disc ML-DmD32  (364) haltere disc ML-DmD17-c3  (363) eye-antennal disc ML-DmD11  (329) antennal disc ML-DmD20-c5  (190) mixed discs ML-DmD4-c1  (160) CNS ML-DmBG1-c1  (175) CNS ML-DmBG2-c2  (164) tumorous blood cells mbn2  (263) ovary fGS/OSS  (153) ovary OSC  (132) ovary OSS  (58) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+  (400) Schneider line 2 Sg4  (233) embryonic 1182-4H  (812) embryonic GM2  (157) embryonic Kc167  (153) embryonic S1  (233) embryonic S3  (161) leg disc CME L1  (430) wing disc CME-W2  (453) wing disc ML-DmD8  (193) wing disc ML-DmD9  (375) wing disc ML-DmD16-c3  (432) wing disc ML-DmD21    64 wing disc ML-DmD32  (364) haltere disc ML-DmD17-c3  (363) eye-antennal disc ML-DmD11  (329) antennal disc ML-DmD20-c5  (190) mixed discs ML-DmD4-c1  (160) CNS ML-DmBG1-c1  (175) CNS ML-DmBG2-c2  (164) tumorous blood cells mbn2  (263) ovary fGS/OSS  (153) ovary OSC  (132) ovary OSS    58 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    400 Schneider line 2 Sg4    233 embryonic 1182-4H    812 embryonic GM2    157 embryonic Kc167    153 embryonic S1    233 embryonic S3    161 leg disc CME L1    430 wing disc CME-W2    453 wing disc ML-DmD8    193 wing disc ML-DmD9    375 wing disc ML-DmD16-c3    432 wing disc ML-DmD21    64 wing disc ML-DmD32    364 haltere disc ML-DmD17-c3    363 eye-antennal disc ML-DmD11    329 antennal disc ML-DmD20-c5    190 mixed discs ML-DmD4-c1    160 CNS ML-DmBG1-c1    175 CNS ML-DmBG2-c2    164 tumorous blood cells mbn2    263 ovary fGS/OSS    153 ovary OSC    132 ovary OSS    58 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    400 Schneider line 2 Sg4    233 embryonic 1182-4H    812 embryonic GM2    157 embryonic Kc167    153 embryonic S1    233 embryonic S3    161 leg disc CME L1    430 wing disc CME-W2    453 wing disc ML-DmD8    193 wing disc ML-DmD9    375 wing disc ML-DmD16-c3    432 wing disc ML-DmD21    64 wing disc ML-DmD32    364 haltere disc ML-DmD17-c3    363 eye-antennal disc ML-DmD11    329 antennal disc ML-DmD20-c5    190 mixed discs ML-DmD4-c1    160 CNS ML-DmBG1-c1    175 CNS ML-DmBG2-c2    164 tumorous blood cells mbn2    263 ovary fGS/OSS    153 ovary OSC    132 ovary OSS    58 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (400) Schneider line 2 Sg4  (233) embryonic 1182-4H  (812) embryonic GM2  (157) embryonic Kc167  (153) embryonic S1  (233) embryonic S3  (161) leg disc CME L1  (430) wing disc CME-W2  (453) wing disc ML-DmD8  (193) wing disc ML-DmD9  (375) wing disc ML-DmD16-c3  (432) wing disc ML-DmD21  (64) wing disc ML-DmD32  (364) haltere disc ML-DmD17-c3  (363) eye-antennal disc ML-DmD11  (329) antennal disc ML-DmD20-c5  (190) mixed discs ML-DmD4-c1  (160) CNS ML-DmBG1-c1  (175) CNS ML-DmBG2-c2  (164) tumorous blood cells mbn2  (263) ovary fGS/OSS  (153) ovary OSC  (132) ovary OSS  (58) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+  (400) Schneider line 2 Sg4  (233) embryonic 1182-4H  (812) embryonic GM2  (157) embryonic Kc167  (153) embryonic S1  (233) embryonic S3  (161) leg disc CME L1  (430) wing disc CME-W2  (453) wing disc ML-DmD8  (193) wing disc ML-DmD9  (375) wing disc ML-DmD16-c3  (432) wing disc ML-DmD21    64 wing disc ML-DmD32  (364) haltere disc ML-DmD17-c3  (363) eye-antennal disc ML-DmD11  (329) antennal disc ML-DmD20-c5  (190) mixed discs ML-DmD4-c1  (160) CNS ML-DmBG1-c1  (175) CNS ML-DmBG2-c2  (164) tumorous blood cells mbn2  (263) ovary fGS/OSS  (153) ovary OSC  132 ovary OSS    58 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    400 Schneider line 2 Sg4    233 embryonic 1182-4H    812 embryonic GM2    157 embryonic Kc167    153 embryonic S1    233 embryonic S3    161 leg disc CME L1    430 wing disc CME-W2    453 wing disc ML-DmD8    193 wing disc ML-DmD9    375 wing disc ML-DmD16-c3    432 wing disc ML-DmD21    64 wing disc ML-DmD32    364 haltere disc ML-DmD17-c3    363 eye-antennal disc ML-DmD11    329 antennal disc ML-DmD20-c5    190 mixed discs ML-DmD4-c1    160 CNS ML-DmBG1-c1    175 CNS ML-DmBG2-c2    164 tumorous blood cells mbn2    263 ovary fGS/OSS    153 ovary OSC    132 ovary OSS    58 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    10 cold shock, 4-day adult    9 heat shock, 4-day adult    16 Cadmium 50 mM 6 hrs, larvae L3    14 Cadmium 50 mM 12 hrs, larvae L3    16 Cadmium 50 mM 48 hrs, 4-day adult    24 Cadmium 100 mM 48 hrs, 4-day adult    4 Copper 0.5 mM 12 hrs, larvae L3    18 Copper 15 mM 48 hrs, 4-day adult    5 Zinc 5 mM 12 hrs, larvae L3    16 Zinc 4.5 mM 48 hrs, 4-day adult    8 Ethanol 2.5% 3 hrs, larvae L3    7 Ethanol 5% 3 hrs, larvae L3    15 Ethanol 10% 3 hrs, larvae L3    17 Caffeine 1.5 mg/ml 4 hrs, larvae L3    17 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    5 Caffeine 25 mg/ml 48 hrs, 4-day adult    8 Paraquat 5 mM 48 hrs, 4-day adult    8 Paraquat 10 mM 48 hrs, 4-day adult    14 Rotenone 2 μg 12 hrs, larvae L3    14 Rotenone 8 μg 12 hrs, larvae L3    15 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    10 cold shock, 4-day adult    9 heat shock, 4-day adult    16 Cadmium 50 mM 6 hrs, larvae L3    14 Cadmium 50 mM 12 hrs, larvae L3    16 Cadmium 50 mM 48 hrs, 4-day adult    24 Cadmium 100 mM 48 hrs, 4-day adult    4 Copper 0.5 mM 12 hrs, larvae L3    18 Copper 15 mM 48 hrs, 4-day adult    5 Zinc 5 mM 12 hrs, larvae L3    16 Zinc 4.5 mM 48 hrs, 4-day adult    8 Ethanol 2.5% 3 hrs, larvae L3    7 Ethanol 5% 3 hrs, larvae L3    15 Ethanol 10% 3 hrs, larvae L3    17 Caffeine 1.5 mg/ml 4 hrs, larvae L3    17 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    5 Caffeine 25 mg/ml 48 hrs, 4-day adult    8 Paraquat 5 mM 48 hrs, 4-day adult    8 Paraquat 10 mM 48 hrs, 4-day adult    14 Rotenone 2 μg 12 hrs, larvae L3    14 Rotenone 8 μg 12 hrs, larvae L3    15 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    10 cold shock, 4-day adult    9 heat shock, 4-day adult    16 Cadmium 50 mM 6 hrs, larvae L3    14 Cadmium 50 mM 12 hrs, larvae L3    16 Cadmium 50 mM 48 hrs, 4-day adult    24 Cadmium 100 mM 48 hrs, 4-day adult    4 Copper 0.5 mM 12 hrs, larvae L3    18 Copper 15 mM 48 hrs, 4-day adult    5 Zinc 5 mM 12 hrs, larvae L3    16 Zinc 4.5 mM 48 hrs, 4-day adult    8 Ethanol 2.5% 3 hrs, larvae L3    7 Ethanol 5% 3 hrs, larvae L3    15 Ethanol 10% 3 hrs, larvae L3    17 Caffeine 1.5 mg/ml 4 hrs, larvae L3    17 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    5 Caffeine 25 mg/ml 48 hrs, 4-day adult    8 Paraquat 5 mM 48 hrs, 4-day adult    8 Paraquat 10 mM 48 hrs, 4-day adult    14 Rotenone 2 μg 12 hrs, larvae L3    14 Rotenone 8 μg 12 hrs, larvae L3    15 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    10 cold shock, 4-day adult    9 heat shock, 4-day adult    16 Cadmium 50 mM 6 hrs, larvae L3    14 Cadmium 50 mM 12 hrs, larvae L3    16 Cadmium 50 mM 48 hrs, 4-day adult    24 Cadmium 100 mM 48 hrs, 4-day adult    4 Copper 0.5 mM 12 hrs, larvae L3    18 Copper 15 mM 48 hrs, 4-day adult    5 Zinc 5 mM 12 hrs, larvae L3    16 Zinc 4.5 mM 48 hrs, 4-day adult    8 Ethanol 2.5% 3 hrs, larvae L3    7 Ethanol 5% 3 hrs, larvae L3    15 Ethanol 10% 3 hrs, larvae L3    17 Caffeine 1.5 mg/ml 4 hrs, larvae L3    17 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    5 Caffeine 25 mg/ml 48 hrs, 4-day adult    8 Paraquat 5 mM 48 hrs, 4-day adult    8 Paraquat 10 mM 48 hrs, 4-day adult    14 Rotenone 2 μg 12 hrs, larvae L3    14 Rotenone 8 μg 12 hrs, larvae L3    15 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    10 cold shock, 4-day adult    9 heat shock, 4-day adult    16 Cadmium 50 mM 6 hrs, larvae L3    14 Cadmium 50 mM 12 hrs, larvae L3    16 Cadmium 50 mM 48 hrs, 4-day adult    24 Cadmium 100 mM 48 hrs, 4-day adult    4 Copper 0.5 mM 12 hrs, larvae L3    18 Copper 15 mM 48 hrs, 4-day adult    5 Zinc 5 mM 12 hrs, larvae L3    16 Zinc 4.5 mM 48 hrs, 4-day adult    8 Ethanol 2.5% 3 hrs, larvae L3    7 Ethanol 5% 3 hrs, larvae L3    15 Ethanol 10% 3 hrs, larvae L3    17 Caffeine 1.5 mg/ml 4 hrs, larvae L3    17 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    5 Caffeine 25 mg/ml 48 hrs, 4-day adult    8 Paraquat 5 mM 48 hrs, 4-day adult    8 Paraquat 10 mM 48 hrs, 4-day adult    14 Rotenone 2 μg 12 hrs, larvae L3    14 Rotenone 8 μg 12 hrs, larvae L3    15 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    10 cold shock, 4-day adult    9 heat shock, 4-day adult    16 Cadmium 50 mM 6 hrs, larvae L3    14 Cadmium 50 mM 12 hrs, larvae L3    16 Cadmium 50 mM 48 hrs, 4-day adult    24 Cadmium 100 mM 48 hrs, 4-day adult    4 Copper 0.5 mM 12 hrs, larvae L3    18 Copper 15 mM 48 hrs, 4-day adult    5 Zinc 5 mM 12 hrs, larvae L3    16 Zinc 4.5 mM 48 hrs, 4-day adult    8 Ethanol 2.5% 3 hrs, larvae L3    7 Ethanol 5% 3 hrs, larvae L3    15 Ethanol 10% 3 hrs, larvae L3    17 Caffeine 1.5 mg/ml 4 hrs, larvae L3    17 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    5 Caffeine 25 mg/ml 48 hrs, 4-day adult    8 Paraquat 5 mM 48 hrs, 4-day adult    8 Paraquat 10 mM 48 hrs, 4-day adult    14 Rotenone 2 μg 12 hrs, larvae L3    14 Rotenone 8 μg 12 hrs, larvae L3    15 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    10 cold shock, 4-day adult    9 heat shock, 4-day adult    16 Cadmium 50 mM 6 hrs, larvae L3    14 Cadmium 50 mM 12 hrs, larvae L3    16 Cadmium 50 mM 48 hrs, 4-day adult    24 Cadmium 100 mM 48 hrs, 4-day adult    4 Copper 0.5 mM 12 hrs, larvae L3    18 Copper 15 mM 48 hrs, 4-day adult    5 Zinc 5 mM 12 hrs, larvae L3    16 Zinc 4.5 mM 48 hrs, 4-day adult    8 Ethanol 2.5% 3 hrs, larvae L3    7 Ethanol 5% 3 hrs, larvae L3    15 Ethanol 10% 3 hrs, larvae L3    17 Caffeine 1.5 mg/ml 4 hrs, larvae L3    17 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    5 Caffeine 25 mg/ml 48 hrs, 4-day adult    8 Paraquat 5 mM 48 hrs, 4-day adult    8 Paraquat 10 mM 48 hrs, 4-day adult    14 Rotenone 2 μg 12 hrs, larvae L3    14 Rotenone 8 μg 12 hrs, larvae L3    15 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    10 cold shock, 4-day adult    9 heat shock, 4-day adult    16 Cadmium 50 mM 6 hrs, larvae L3    14 Cadmium 50 mM 12 hrs, larvae L3    16 Cadmium 50 mM 48 hrs, 4-day adult    24 Cadmium 100 mM 48 hrs, 4-day adult    4 Copper 0.5 mM 12 hrs, larvae L3    18 Copper 15 mM 48 hrs, 4-day adult    5 Zinc 5 mM 12 hrs, larvae L3    16 Zinc 4.5 mM 48 hrs, 4-day adult    8 Ethanol 2.5% 3 hrs, larvae L3    7 Ethanol 5% 3 hrs, larvae L3    15 Ethanol 10% 3 hrs, larvae L3    17 Caffeine 1.5 mg/ml 4 hrs, larvae L3    17 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    5 Caffeine 25 mg/ml 48 hrs, 4-day adult    8 Paraquat 5 mM 48 hrs, 4-day adult    8 Paraquat 10 mM 48 hrs, 4-day adult    14 Rotenone 2 μg 12 hrs, larvae L3    14 Rotenone 8 μg 12 hrs, larvae L3    15 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_11
External Data & Images
Linkouts	BDGP expression data • PC00106 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0002526 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG10236-RA FlyExpress - Embryonic expression images (BDGP data) • Show all FlyExpress processed images for LanA Stages(s) 4-6 Stages(s) 7-8 Stages(s) 9-10 Stages(s) 11-12 Stages(s) 13-16
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal LanA1 lethal | embryonic stage | recessive LanA6-36 LanA7-5 LanA9-32 lethal | recessive LanA4A8 LanA25 LanA81L LanA160 LanA216 viable, with Scer\GAL4pnr-MD237 LanAGD6022 viable (with LanA9-32) LanAC01-190 viable (with LanAC01-190) LanA9-32 Other Phenotypes Allele behavior defective | recessive LanABG01662 immune response defective | larval stage LanAf05927 meiotic cell cycle defective | dominant LanAScim neuroanatomy defective LanA9-32 neuroanatomy defective | embryonic stage LanA9-32 neuroanatomy defective | larval stage, with Scer\GAL4elav-C155 LanAEP3678 neuroanatomy defective | third instar larval stage, with LanA9-32, Scer\GAL4C57 LanAGD6022 neuroanatomy defective | third instar larval stage, with LanAGD6022, Scer\GAL4C57 LanA9-32 neuroanatomy defective | third instar larval stage, with Scer\GAL4C57 LanAC01-190 Phenotype manifest in Allele abdominal 1 ventral acute muscle 3 | embryonic stage LanA9-32 abdominal 1 ventral oblique muscle 4 | embryonic stage LanA9-32 abdominal 1 ventral oblique muscle 5 | embryonic stage LanA9-32 abdominal 2 ventral acute muscle 3 | embryonic stage LanA9-32 abdominal 2 ventral oblique muscle 4 | embryonic stage LanA9-32 abdominal 2 ventral oblique muscle 5 | embryonic stage LanA9-32 abdominal 2 ventral oblique muscle 6 | embryonic stage LanA9-32 abdominal 3 ventral acute muscle 3 | embryonic stage LanA9-32 abdominal 3 ventral oblique muscle 4 | embryonic stage LanA9-32 abdominal 3 ventral oblique muscle 5 | embryonic stage LanA9-32 abdominal 3 ventral oblique muscle 6 | embryonic stage LanA9-32 abdominal 4 ventral acute muscle 3 | embryonic stage LanA9-32 abdominal 4 ventral oblique muscle 4 | embryonic stage LanA9-32 abdominal 4 ventral oblique muscle 5 | embryonic stage LanA9-32 abdominal 4 ventral oblique muscle 6 | embryonic stage LanA9-32 abdominal 5 ventral acute muscle 3 | embryonic stage LanA9-32 abdominal 5 ventral oblique muscle 4 | embryonic stage LanA9-32 abdominal 5 ventral oblique muscle 5 | embryonic stage LanA9-32 abdominal 5 ventral oblique muscle 6 | embryonic stage LanA9-32 abdominal 6 ventral acute muscle 3 | embryonic stage LanA9-32 abdominal 6 ventral oblique muscle 4 | embryonic stage LanA9-32 abdominal 6 ventral oblique muscle 5 | embryonic stage LanA9-32 abdominal 6 ventral oblique muscle 6 | embryonic stage LanA9-32 abdominal 7 ventral acute muscle 3 | embryonic stage LanA9-32 abdominal 7 ventral oblique muscle 4 | embryonic stage LanA9-32 abdominal 7 ventral oblique muscle 5 | embryonic stage LanA9-32 abdominal 7 ventral oblique muscle 6 | embryonic stage LanA9-32 amnioserosa LanA9-32 antenna LanA160 LanA216 LanA25 LanA81L anterior fascicle & synapse, with Scer\GAL4elav-C155 LanAEP3678 bouton & neuromuscular junction & embryo LanA9-32 cone cell LanA160 LanA216 LanA25 LanA81L dorsal superficial trachea LanA9-32 egg chamber | germline clone LanA9-32 embryo LanA9-32 embryonic/larval dorsal vessel LanAA6-36 embryonic/larval midgut & endoderm LanA9-32 embryonic/larval midgut | embryonic stage LanA3A1 LanA4A8 LanA6A1 LanA6A52 embryonic/larval optic stalk LanA160 LanA216 LanA25 LanA6-36 LanA81L embryonic/larval pericardial cell | embryonic stage LanA9-32 embryonic/larval proventriculus | embryonic stage LanA3A1 LanA4A8 LanA6A1 LanA6A52 embryonic/larval somatic muscle LanA9-32 embryonic head LanA3A1 LanA4A8 LanA6A1 LanA6A52 extracellular matrix LanA160 LanA216 LanA25 LanA6-36 LanA81L eye LanA160 LanA216 LanA25 LanA81L eye photoreceptor cell LanA160 LanA216 LanA25 LanA81L eye photoreceptor cell & axon LanA160 LanA216 LanA25 LanA6-36 LanA81L fascicle LanA9-32 germline cell LanA6-26 glial cell LanA160 LanA216 LanA25 LanA6-36 LanA81L intersegmental nerve, with Scer\GAL4elav-C155 LanAEP3678 leg LanA160 LanA216 LanA25 LanA81L macrochaeta LanABG01150 muscle attachment site & basal lamina LanA9-32 neuromuscular junction | third instar larval stage, with LanA9-32, Scer\GAL4C57 LanAGD6022 neuromuscular junction | third instar larval stage, with LanAGD6022, Scer\GAL4C57 LanA9-32 neuromuscular junction | third instar larval stage, with Scer\GAL4C57 LanAC01-190 ocellar bristle LanA160 LanA216 LanA25 LanA81L ocellar nerve LanA160 LanA216 LanA25 LanA6-36 LanA81L ocellar nerve & axon LanA160 LanA216 LanA25 LanA6-36 LanA81L ocellus LanA160 LanA216 LanA25 LanA81L ommatidial precursor cluster LanA160 LanA216 LanA25 LanA81L oocyte nucleus | cell non-autonomous | somatic clone LanA9-32 optic nerve LanA160 LanA216 LanA25 LanA6-36 LanA81L postvertical bristle LanA160 LanA216 LanA25 LanA81L presumptive embryonic/larval central nervous system LanA1 presumptive embryonic/larval peripheral nervous system LanA1 wing LanA160 LanA216 LanA25 LanA81L
Classical Alleles ( 25 )
For All Classical Alleles Show
Allele of LanA Class Mutagen Stocks Known lesion LanAf05927 piggyBac transposase 1 -- LanAMB01129 1 -- LanAMI02491 1 -- LanAMI06740 1 -- LanAScim Delta2-3 1 Yes LanA9-32 amorphic allele - genetic evidence, loss of function allele Delta2-3 0 Yes LanA160 hypomorphic allele - genetic evidence ethyl methanesulfonate 0 -- LanA1 0 -- LanA216 hypomorphic allele - genetic evidence ethyl methanesulfonate 0 -- LanA25 hypomorphic allele - genetic evidence ethyl methanesulfonate 0 -- LanA3A1 0 -- LanA4A8 0 -- LanA6-26 0 -- LanA6-36 loss of function allele Delta2-3 0 Yes LanA6A1 0 -- LanA6A52 0 -- LanA7-5 Delta2-3 0 Yes LanA81L hypomorphic allele - genetic evidence ethyl methanesulfonate 0 -- LanAA6-36 0 -- LanABG01150 P-element activity 0 Yes LanABG01662 0 -- LanAC01-190 0 Yes LanAEP3678 P-element activity 0 Yes LanAEP440 P-element activity 0 -- LanAGS6075 0 --
Alleles Carried on Transgenic Constructs ( 5 )
For All Alleles Carried on Transgenic Constructs Show
Allele of LanA Class Mutagen Stocks Known lesion LanAGD6022 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes LanAJF02908 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes LanAdsRNA.cGa in vitro construct - RNAi 0 Yes LanAL.hs in vitro construct - regulatory fusion 0 Yes LanAS.hs in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(3L)Exel8101 (Ryder, 2004.4.26) Df(3L)Vn-2 (Henchcliffe et al., 1993) Df(3L)ZN47 (Harding et al., 1995)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD6022} NA P{TRiP.JF02908} NA
Insertions
	Type of insertions Name Expression data insertion of mobile activating element P{EP}EP477 NA P{EP}EP664 NA P{EP}EP903 NA P{EP}EP943 NA P{EP}EP3244 NA P{EP}EP3414 NA P{EP}EP3453 NA P{EP}LanAC01-190 NA P{EP}LanAEP440 NA P{EP}LanAEP3678 NA P{GSV3}LanAGS6075 NA miscellaneous insertions Mi{MIC}LanAMI02491 NA Mi{MIC}LanAMI06740 NA P{GT1}LanABG01150 NA P{GT1}LanABG01662 NA P{PTT-GB}CB04172 NA P{SUPor-P}LanAScim NA P{UASp-YFP.Rab5.Q88L}01a NA P{UASp-YFP.Rab10}21 NA PBac{WH}LanAf05927 NA insertion of enhancer trap H{Lw2}SW8 No insertion of enhancer trap binary system Mi{ET1}LanAMB01129 No P{GAL4}toi1 No
Gene Ontology: Function, Process & Cellular Component ( 25 unique terms )
Terms Based on Experimental Evidence ( 15 terms )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
axon guidance inferred from mutant phenotype (Stevens and Jacobs, 2002) brain morphogenesis inferred from mutant phenotype (Yamamoto et al., 2008) dorsal trunk growth, open tracheal system inferred from mutant phenotype (Stark et al., 1997) female meiosis chromosome segregation inferred from mutant phenotype (Dobie et al., 2001) heart development inferred from mutant phenotype (Haag et al., 1999) imaginal disc-derived wing morphogenesis inferred from mutant phenotype (Carreira et al., 2011) inter-male aggressive behavior inferred from mutant phenotype (Edwards et al., 2009) locomotion involved in locomotory behavior inferred from mutant phenotype (Yamamoto et al., 2008) melanotic encapsulation of foreign target inferred from mutant phenotype (Howell et al., 2012) mesoderm development inferred from expression pattern (Furlong et al., 2001) negative regulation of synaptic growth at neuromuscular junction inferred from mutant phenotype (Tsai et al., 2012) startle response inferred from mutant phenotype (Yamamoto et al., 2008)
Cellular Component
CV term Evidence References
basal lamina inferred from direct assay (Fessler et al., 1994) basement membrane inferred from direct assay (Kusche-Gullberg et al., 1992) presynaptic periactive zone inferred from direct assay (Tsai et al., 2012)
Terms Based on Predictions or Assertions ( 11 terms )
Molecular Function
CV term Evidence References
receptor binding inferred from electronic annotation with InterPro:IPR009254 (FlyBase Curators et al., 2004-)
Biological Process
CV term Evidence References
central nervous system development non-traceable author statement (Goodman et al., 1989) embryonic morphogenesis non-traceable author statement (Swiss-Prot Project Members, 1997.2.1) organ morphogenesis non-traceable author statement (Swiss-Prot Project Members, 1997.2.1) peripheral nervous system development non-traceable author statement (Goodman et al., 1989) regulation of cell adhesion inferred from electronic annotation with InterPro:IPR009254 (FlyBase Curators et al., 2004-) regulation of cell migration inferred from electronic annotation with InterPro:IPR009254 (FlyBase Curators et al., 2004-) regulation of embryonic development inferred from electronic annotation with InterPro:IPR009254 (FlyBase Curators et al., 2004-) tissue development non-traceable author statement (Swiss-Prot Project Members, 1997.2.1)
Cellular Component
CV term Evidence References
basement membrane inferred from sequence or structural similarity (Hynes and Zhao, 2000) inferred from sequence or structural similarity with mouse Lama1 (FlyBase, 1992-) non-traceable author statement (Swiss-Prot Project Members, 1997.2.1) laminin-1 complex inferred from electronic annotation with InterPro:IPR009254 (FlyBase Curators et al., 2004-)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
protein-protein
Interacting group Assay References
LanA - Gp210 experimental knowledge based (Guruharsha et al., 2011) LanA - LRP1 experimental knowledge based (Guruharsha et al., 2011) LanA - LanB1 experimental knowledge based (Guruharsha et al., 2011) LanA - LanB2 experimental knowledge based (Guruharsha et al., 2011)
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions LanA allele Gene References LanA3A1 Dfd (Harding et al., 1995, Gellon et al., 1997) peb (Wilk et al., 2004) LanA4A8 Dfd (Harding et al., 1995, Gellon et al., 1997) peb (Wilk et al., 2004) LanA6-36 sog (Araujo et al., 2003) LanA6A1 Dfd (Harding et al., 1995, Gellon et al., 1997) LanA6A52 Dfd (Harding et al., 1995, Gellon et al., 1997) LanA9-32 if (Prokop et al., 1998) sog (Araujo et al., 2003) LanA25 sog (Araujo et al., 2003) LanA216 sog (Araujo et al., 2003) unspecified Cg25C (Gellon et al., 1997) Dfd   Nsf2 (Laviolette et al., 2005) sli (MacMullin and Jacobs, 2006) vkg (Gellon et al., 1997)
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 64176 DroID - A comprehensive database of gene and protein interactions. • FBgn0002526 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 38723
Orthologs
OrthoDB Orthologs (49) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG6FFDM3 Dipteran inclusive ortholog search EOG6QC1D8 Insect inclusive ortholog search EOG6PZH2D Arthropod inclusive ortholog search EOG6TDZ10 Metazoa inclusive ortholog search EOG66TFT5
Orthologs in Drosophila Species (EOG6FFDM3)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\LanA     Drosophila simulans   Dsim\GD13136 Y   Drosophila sechellia   Dsec\GM13851 Y   Drosophila erecta   Dere\GG14069 Y   Drosophila yakuba   Dyak\GE20494 Y   Drosophila ananassae   Dana\GF10909 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA10179 Y   Drosophila persimilis   Dper\GL22528 Y   Drosophila willistoni   Dwil\GK17256 Y   Drosophila virilis   Dvir\GJ12003 Y   Drosophila mojavensis   Dmoj\GI13231     Drosophila grimshawi   Dgri\GH16286 Y
Orthologs in non-Drosophila Dipterans (EOG6QC1D8)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL008773   Anopheles gambiae Malaria mosquito  Agam\AGAP004993   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ003989
Orthologs in non-Dipteran Insects (EOG6PZH2D)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\GB41930   Apis mellifera Western honey bee  Amel\GB49929   Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG014878   Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG014880   Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH17527   Atta cephalotes Leafcutter ant  Acep\ACEP12946   Camponotus floridanus Florida carpenter ant  Cflo\CFLO12778   Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL23376   Linepithema humile Argentine ant  Lhum\LH17687   Pogonomyrmex barbatus Red harvester ant  Pbar\PB18333   Solenopsis invicta Red fire ant  Sinv\SINV21821   Acyrthosiphon pisum Pea aphid  Apim\ACYPI010019   Bombyx mori Silkmoth  Bmor\BGIBMGA002018   Pediculus humanus Human body louse  Phum\PHUM624880   Pediculus humanus Human body louse  Phum\PHUM537140   Tribolium castaneum Red flour beetle  Tcas\LanA   Tribolium castaneum Red flour beetle  Tcas\TC003461
Orthologs in non-Insect Arthropods (EOG6TDZ10)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\CAL   Ixodes scapularis Deer tick  Isca\ISCW006727   Ixodes scapularis Deer tick  Isca\ISCW006728
Orthologs in non-Arthropod Metazoa (EOG66TFT5)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Caenorhabditis elegans Nematode  Cele\epi-1   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_020192gn   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_013481gn   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_027389gn   Danio rerio Zebrafish  Drer\lama5   Xenopus tropicalis Western clawed frog  Xtro\lama5   Xenopus tropicalis Western clawed frog  Xtro\lama3   Gallus gallus Domestic chicken  Ggal\LAMA5   Gallus gallus Domestic chicken  Ggal\LAMA3   Mus musculus House mouse  Mmus\Lama3   Mus musculus House mouse  Mmus\Lama5   Rattus norvegicus Norway rat  Rnor\ENSRNOG00000011300   Rattus norvegicus Norway rat  Rnor\Lama5   Homo sapiens Human  Hsap\LAMA3
Human Orthologs (1)
Gene OMIM HGNC Hsap\LAMA3
AAA Orthologs (10) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD13136 Drosophila sechellia Dsec\GM13851 Drosophila erecta Dere\GG14069 Drosophila yakuba Dyak\GE20494 Drosophila ananassae Dana\GF10909 Drosophila pseudoobscura pseudoobscura Dpse\GA10179 Drosophila persimilis Dper\GL22528 Drosophila willistoni Dwil\GK17256 Drosophila virilis Dvir\GJ12003 Drosophila grimshawi Dgri\GH16286
Stocks & Reagents
Stocks Listed in FlyBase ( 7 )
Bloomington	28071 y1 v1; P{TRiP.JF02908}attP2 14568 y1; P{SUPor-P}LanAScim ry506 23555 w1118; Mi{ET1}LanAMB01129/TM6C, Sb1 35991 y1 w*; Mi{MIC}LanAMI02491/TM3, Sb1 Ser1 42430 y1 w*; Mi{MIC}LanAMI06740/TM3, Sb1 Ser1
Harvard	- PBac{WH}LanAf05927
VDRC	v18873 w1118; P{GD6022}v18873
Genomic Clones ( 1 )
	BACR09G21 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 113 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones
Other clones	SD07123
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	GH27482 GM04106 GM31829 GM31830 LP10521 LP16745 LP20963 RH04553 RH22149 RH35767 RH37303 RH57211 RH61982 SD01803 SD02129 SD05238 SD06693 SD06756 SD07033 SD09159 SD09163 SD10526 SD10890 SD12117 SD13902 SD14178 SD16995 SD17367 SD19338 SD21020 SD21630 SD21721 SD21889 SD22410 SD22943 SD23302 SD24328 SD24721 SD25121 SD25441 SD25651 SD27267
Other clones	39990 55948 61726 80264 97105 100289 122090 146014 149740 165701 165872 189943 214469.17 214469.18 522185 522673 562135 572735 CK01.5C.E10 CK01.30A.A8 CK01.36D.A2 CK01.55B.E5 CK01.61A.D2 CK01.94C.H9 CK01.113B.D11 CK01.141A.C6 EC26563 EC37563 EK026436 EK031333 EK044919 EK073729 EK116943 EK153462 EK168707 EK184948 EK190955 EK212655 EK219632 EK222959 EK252444 EK255833 EK270283 EK270427 EK292112 EN01203 EN01321 EN01525 EN02536 EN04806 EN13762 EN16944 EP06962 EP08064 FGM101H06 FGM310C01 LD23706 LD24387 LP01316 RP004054522 RP004109985 RP004146783 RP004170937 RP004181076 RP004224426 RP004226704 RP004474431 RP004490696 RP004515483 RP004535849
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0002526 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 38723
Antibody Information
	monoclonal (Montell and Goodman, 1989, Kumagai et al., 2000) polyclonal (Tsai et al., 2012, Garrison et al., 1991, Kusche-Gullberg et al., 1992, Gullberg et al., 1994)
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: LanA CG10236 (Gabrielian, 1999.11)
Source for database merge of
Additional comments
Other Comments
	dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology. (Kiger et al., 2003) LanA is not required for heart morphogenesis, but does play a role in the maintenance of the heart's ultrastructure. (Haag et al., 1999) In a sample of 79 genes with multiple introns, 33 showed significant heterogeneity in G+C content among introns of the same gene and significant positive correspondence between the intron and the third codon position G+C content within genes. These results are consistent with selection adding against preferred codons at the start of genes. (Kliman and Eyre-Walker, 1998) Identified in a screen for modifiers of the Dfd13/Dfd3 mutant phenotype. Shows no interaction with the Pc mutant phenotype. (Gellon et al., 1997) Chain-specific polyclonal antibodies reveal that LanB1 and LanB2 form a stable dimer before they are disulfide-bonded to each other. LanA associates with neither monomeric LanB1, monomeric LanB2 nor LanB1 LanB2 dimer without disulfide-bonding but only with disulfide-bonded LanB1 LanB2 dimer to form LanA LanB1 LanB2 trimers. Results demonstrate that the interchain disulfide-bonding between LanB1 and LanB2 is essential for LanA LanB1 LanB2 trimer formation. (Kumagai et al., 1997) LanA demonstrates evolutionary conservation of binding properties similar to mammalian laminin. LanA binds mammalian nidogen and perlecan, similar proteins may exist in Drosophila. (Mayer et al., 1997) Extracellular matrix containing LanA gene product is required for ocellar axon pathfinding. (Garcia-Alonso et al., 1996) Cell attachment activities of LanA peptides suggest that active regions in the G domain play an important role in cell surface receptor interactions. (Nomizu et al., 1996) Examination of mutant embryos and the function of Msp-300 during embryonic muscle development suggests a functional link between LanA and Msp-300 in the development of the embryonic somatic musculature. (Rosenberg-Hasson et al., 1996) Mutations of LanA show striking abnormalities in growth cone guidance of ocellar pioneer (OP) axons. (Garcia-Alonso et al., 1995) Mutations of LanA interact with Dfd to reduce the viability of the Dfd3/Dfd13 combination. (Harding et al., 1995) LanA function is not required for the early phases of mesoderm patterning and morphogenesis in embryos at the extended germ band stage. Function is required for the proper morphogenesis of the heart, somatic mesoderm and gut during later stages of embryonic development. The endoderm fails to undergo the initial columnar polarisation in the absence of functional LanA. These results indicate that the primary function of LanA is to provide structural support for the various cell types, enabling their proper organisation into the various organs. (Yarnitzky and Volk, 1995) Lack of LanA causes derangement in the patterning of the somatic muscles. (Volk et al., 1994) Clonal analysis revealed that the gene product functions in a non-cell autonomous fashion. (Henchcliffe et al., 1993) The LanA gene product is required for diverse functions during morphogenesis. (Henchcliffe et al., 1993) LanA gene cloned and expression pattern studied: changes in expression precede those of Cg25C. (Kusche-Gullberg et al., 1992) The three Laminin genes (LanA, LanB1 and LanB2) encode the three subunits of Drosophila laminin, which associate to form a cruciform molecule in which the carboxy-terminal ends are α helical and associate with one another and whose amino-terminal ends are free to form three short arms of the cross. (Lindsley and Zimm, 1992) The three Laminin genes (LanA, LanB1 and LanB2) encode the three subunits of laminin, a substrate adhesion molecule shown to be a potent promoter of neurite outgrowth. (Goodman et al., 1989)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_057269 RefSeq (Proteins) • NP_476617 DDBJ / EMBL / GenBank • AA820583 AAA28661 AAA28662 AAC37178 AAF50672 AC004357 AC004767 AI534327 AQ025086 AQ073113 AW942703 BG639824 CZ488559 L07288 M75882 M96388 Entrez Gene - A searchable database of RefSeq genes. • 38723 UniProtKB/Swiss-Prot • Q00174
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Laminin B, subgroup (IPR018031) Laminin B type IV (IPR000034) Laminin G domain (IPR001791) EGF-like, laminin (IPR002049) Laminin, N-terminal (IPR008211) Concanavalin A-like lectin/glucanases superfamily (IPR008985) Laminin I (IPR009254) Laminin II (IPR010307) EGF-like, conserved site (IPR013032) Concanavalin A-like lectin/glucanase, subgroup (IPR013320) BDGP expression data - Patterns of gene expression in Drosophila embryogenesis • PC00106
Linkouts
	BioGRID - A database of protein and genetic interactions • 64176 DroID - A comprehensive database of gene and protein interactions. • FBgn0002526 DRSC - Results from RNAi screens. • FBgn0002526 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0002526 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG10236-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0002526 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 38723 Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution • /newgene/laminna1.htm InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 38723 modMine - Data generated by the modENCODE project. • FBgn0002526
Synonyms & Secondary IDs ( 31 )
Reported As
Symbol Synonym	CG10236 (Norga et al., 2003, Kraut et al., 2001, Kraut et al., 2001, Fakhouri et al., 2006, Laviolette et al., 2005, Hollien and Weissman, 2006, Perkins et al., 2009, Bronstein et al., 2010, Cammarato et al., 2011, Howell et al., 2012) CT28769 (Hynes and Zhao, 2000) FBgn0002526 (Lehmann et al., 2010) FBtr0077014 (Li et al., 2012) hdln (Harding et al., 1995, ) Lam (Denef et al., 2008, Schneider and Baumgartner, 2008) lamA (Araujo et al., 2003, Garcia-Alonso, 1999, Prokop, 1999, Martin et al., 1999, Haag et al., 1999, Prokop et al., 1998, Stark et al., 1997, Gullberg and Ekblom, 1995, Jaglarz and Howard, 1995, Yarnitzky and Volk, 1995, Gotwals et al., 1994, Garcia-Alonso et al., 1993, Henchcliffe et al., 1993) Lam-A (Henchcliffe, 1992, ) LamA (Mayer et al., 1997, Rosenberg-Hasson et al., 1996, Garcia-Alonso et al., 1996, Garcia-Alonso et al., 1995) Lam A (Froldi et al., 2010) laminin α3/5 (Narita et al., 2004) Lan (Poulton and Deng, 2006, Baena-Lopez et al., 2008) lanA (MacMullin and Jacobs, 2006, Anholt and Mackay, 2001, Deng et al., 2001, Brown, 2000, Deng and Ruohola-Baker, 2000, Deng and Ruohola-Baker, 2000, Schneider et al., 2006) LanA (Molnar and de Celis, 2006, Laviolette et al., 2005, Hollien and Weissman, 2006, Hollien and Weissman, 2006, Tsai et al., 2012, Vanderploeg et al., 2012, Buszczak et al., 2007, Hueber et al., 2007, Zhang et al., 2007, Zeitouni et al., 2007, Szafranski and Goode, 2007, Lee et al., 2008, Kallappagoudar et al., 2010, Tsai et al., 2008, O'Reilly et al., 2008, Inoue and Hayashi, 2007, Tanentzapf et al., 2007, Yamamoto et al., 2008, Carreira et al., 2009, De Luca et al., 2008, Morozova et al., 2007, Zhang et al., 2008, Bronstein et al., 2010, Howell et al., 2012, Han et al., 2012, Carreira et al., 2011, Yamamoto et al., 2009, Kaushik et al., 2012) LM-A/α1 (Hynes and Zhao, 2000) α3/5 (Friedrich et al., 2000) α3,5 (Urbano et al., 2009)
Name Synonym	headline (Harding et al., 1995, ) Laminin (Bogdanik et al., 2008, Deng et al., 2003, Poulton and Deng, 2006, Poulton and Deng, 2006, Wei et al., 2004, Szafranski and Goode, 2007, Denef et al., 2008, Schneider and Baumgartner, 2008) laminin (Mirth and Akam, 2002, Cohen et al., 2002, Kramerov and Fessler, 2000, Lo and Frasch, 2001, Ui-Tei and Miyata, 2000, Kramerov and Fessler, 2001, Taylor, 2000, Takagi et al., 2000, Stevens and Jacobs, 2000, Volk, 1999, Kumagai et al., 1999, Fessler et al., 1994, Volk et al., 1990, Araujo et al., 2003, Gullberg et al., 1994) laminin A (Lopez-Schier, 2003, Garrison, 1991, Haag et al., 1998, Fristrom et al., 1993, Gellon et al., 1997, Starr and Fischer, 2005, Neisch et al., 2010, O'Reilly et al., 2008, Sorrosal et al., 2010, Bunt et al., 2010, Park et al., 1997) LamininA (Brown et al., 2000, Murakami et al., 2007, Begun et al., 2007, Tanentzapf et al., 2007) Laminin A (Frydman et al., 2006, Ray et al., 2007, Fakhouri et al., 2006, Christoforou et al., 2008, Urbano et al., 2011, Yamamoto et al., 2008, Carreira et al., 2009, Edwards et al., 2009, Morozova et al., 2007, Froldi et al., 2010, Cammarato et al., 2011, Harbison and Sehgal, 2008, Yamamoto et al., 2009) lamininA (Vandenborre et al., 2010) Laminin A5 (Banyai and Patthy, 2004) laminin α (Goto et al., 2001, Takagi et al., 1996, Takagi et al., 2004, Kumagai et al., 2000) Laminin α3,5 (Brown et al., 2000) laminin α3,5 (Martin et al., 1999, Martinek et al., 2008) laminin α3,5 (Urbano et al., 2009) laminin α-chain (Yurchenco and O'Rear, 1994) α3,5 laminin (O'Reilly et al., 2008)
Secondary FlyBase IDs
	FBgn0015948
References ( 189 )
Generate a list of	All references relating to this gene ( 189 )
List References by type	Research paper  ( 117 ) Supplementary material  ( 13 ) Review  ( 17 ) Personal communication to FlyBase  ( 12 ) Abstract  ( 19 ) FlyBase analysis  ( 2 ) DNA/RNA sequence record  ( 3 ) Curated genome annotation  ( 3 ) Book  ( 1 ) Protein sequence record  ( 1 ) Website  ( 1 )
Recent research papers ( 10 )
	Han et al., 2012, Neuron 73(1): 64--78 Integrins Regulate Repulsion-Mediated Dendritic Patterning of Drosophila Sensory Neurons by Restricting Dendrites in a 2D Space. [FBrf0217239] Howell et al., 2012, Immunogenetics 64(2): 155--161 A directed miniscreen for genes involved in the Drosophila anti-parasitoid immune response. [FBrf0217123] Koper et al., 2012, PLoS ONE 7(4): e36339 Analysis of Adhesion Molecules and Basement Membrane Contributions to Synaptic Adhesion at the Drosophila Embryonic NMJ. [FBrf0218212] Li et al., 2012, Cell Rep. 1(1): 69--82 Global analysis of RNA secondary structure in two metazoans. [FBrf0219052] Tsai et al., 2012, Proc. Natl. Acad. Sci. U.S.A. 109(43): 17699--17704 Activity-dependent retrograde laminin A signaling regulates synapse growth at Drosophila neuromuscular junctions. [FBrf0219768] Vanderploeg et al., 2012, BMC Dev. Biol. 12: 8 Integrins are required for cardioblast polarisation in Drosophila. [FBrf0217831] Baycin-Hizal et al., 2011, J. Proteome Res. 10(6): 2777--2784 GlycoFly: A Database of Drosophila N-linked Glycoproteins Identified Using SPEG-MS Techniques. [FBrf0213834] Carreira et al., 2011, BMC Dev. Biol. 11: 32 Genetic basis of wing morphogenesis in Drosophila: sexual dimorphism and non-allometric effects of shape variation. [FBrf0214273] Urbano et al., 2011, PLoS ONE 6(9): e23893 PS Integrins and Laminins: Key Regulators of Cell Migration during Drosophila Embryogenesis. [FBrf0216260] Zwarts et al., 2011, Proc. Natl. Acad. Sci. U.S.A. 108(41): 17070--17075 Complex genetic architecture of Drosophila aggressive behavior. [FBrf0216413] Show all research papers ...
Recent reviews ( 2 )
	Kaushik et al., 2012, J. Cell. Mol. Med. 16(8): 1656--1662 Measuring passive myocardial stiffness in Drosophila melanogaster to investigate diastolic dysfunction. [FBrf0219008] Broadie et al., 2011, Dev. Neurobiol. 71(11): 1102--1130 Extracellular matrix and its receptors in drosophila neural development. [FBrf0216377] Show all reviews ...