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Gene Dmel\Lcp6

General Information
Symbol	Dmel\Lcp6	Species	D. melanogaster
Name	Larval cuticle protein 6	Annotation symbol
Feature type	gene	FlyBase ID	FBgn0002537
Gene Model Status	Unannotated	Stock availability	None publicly available
Also Known As	LCP6
Genomic Location
Chromosome (arm)		Recombination map	3-11
Cytogenetic map	65A5-65A6	Sequence location
Summary Information
Automatically generated summary See sections below for more information	The gene Larval cuticle protein 6 is referred to in FlyBase by the symbol Dmel\Lcp6 (FBgn0002537). It is a gene from Drosophila melanogaster. It is reported to have molecular function: structural constituent of chitin-based larval cuticle. The biological processes in which it is involved are not known. 3 alleles are reported. No phenotypic data is available. It has no annotated transcripts. Protein features are: Insect cuticle protein. Gene has not been localized to the genome sequence.
User Contributed Data
	Beta version, feedback welcome
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 65A5-65A6   Left limit from sequence databank entry U84756 Right limit from sequence databank entry U84756
Experimentally Determined Cytological Location
Cytogenetic map Notes References 65A-65A     (Charles et al., 1996)
Experimentally Determined Recombination Data
Location	3-11 (Chihara and Kimbrell, 1986)
Left of (cM)
Right of (cM)
Notes	Not separated from Lcp65Ab1 in 487 progeny.   No recombinants with Lcp65Ab1. (Chihara and Kimbrell, 1986)
Gene Model & Products
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa)
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Insect cuticle protein (IPR000618)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name U84756   U84757 AAB48464
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	P92184
Mapped Features
Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
modENCODE Anatomy RNA-Seq
modENCODE Development RNA-Seq
modENCODE Cell Lines RNA-Seq
modENCODE Treatments RNA-Seq
Expression Clusters
External Data & Images
Linkouts
Alleles & Phenotypes
Summary of Allele Phenotypes
Other Phenotypes Allele electrophoretic variant Lcp6f Lcp6S Phenotype manifest in Allele
Classical Alleles ( 3 )
For All Classical Alleles Show
Allele of Lcp6 Class Mutagen Stocks Known lesion Lcp6f natural population 0 -- Lcp6n loss of function allele natural population 0 -- Lcp6S natural population 0 --
Alleles Carried on Transgenic Constructs ( 0 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Lcp6 Class Mutagen Stocks Known lesion
Aneuploid Aberrations
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data
Insertions
	Type of insertions Name Expression data
Gene Ontology: Function, Process & Cellular Component ( 2 unique terms )
Terms Based on Experimental Evidence ( 0 terms )
Terms Based on Predictions or Assertions ( 2 terms )
Molecular Function
CV term Evidence References
structural constituent of chitin-based larval cuticle non-traceable author statement (FlyBase, 1992-) structural constituent of cuticle inferred from electronic annotation with InterPro:IPR000618 (FlyBase Curators et al., 2004-)
Biological Process ( 0 terms)
Cellular Component ( 0 terms)
Sequence Ontology: Class of Gene
	gene
Interactions & Pathways
Summary of Physical Interactions
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Lcp6 allele Gene References
External Data
Linkouts
Orthologs
OrthoDB Orthologs (0) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search No orthologs identified Dipteran inclusive ortholog search No orthologs identified Insect inclusive ortholog search No orthologs identified Arthropod inclusive ortholog search No orthologs identified Metazoa inclusive ortholog search No orthologs identified
Orthologs in Drosophila Species (None identified)
No orthologies identified
Orthologs in non-Drosophila Dipterans (None identified)
No non-Drosophilid orthologies identified
Orthologs in non-Dipteran Insects (None identified)
No non-Dipteran orthologies identified
Orthologs in non-Insect Arthropods (None identified)
No non-Insect Arthropod orthologies identified
Orthologs in non-Arthropod Metazoa (None identified)
No non-Arthropod Metazoa orthologies identified
Human Orthologs (0)
Gene OMIM HGNC
AAA Orthologs (0) based on analysis using Dmel annotation version 4.3
No orthologs identified
Stocks & Reagents
Stocks Listed in FlyBase ( 0 )
Genomic Clones ( 0 )
cDNA Clones ( 0 )
cDNA Clones, Fully Sequenced
BDGP DGC clones
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones
Other clones
RNAi & Array Information
Linkouts
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of
Additional comments	The initial amino terminal residues of the "Lcp6" protein are identical to those of the LCP5 protein encoded by "Lcp65Ab1" and "Lcp65Ab2". The "Lcp6" protein may be encoded by an extra copy of the "Lcp-b" gene (Lcp65Ab3) present in the Canton S strain. (Charles et al., 1998)
Other Comments
	The larval cuticle protein genes Lcp65Ab1, Lcp6, Lcp65Ag1 and Lcp65Ab1 are located in a cluster within 0.3 map units if each other on the third chromosome. (Chihara and Kimbrell, 1986) One of a series of genes encoding electrophoretically separable proteins extractable from the cuticles of third instar larvae, but not other stages.
External Crossreferences & Linkouts
Sequence Crossreferences
	DDBJ / EMBL / GenBank • AAB48463 AAB48464 U84756 U84757 UniProtKB/TrEMBL • P92184
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Insect cuticle protein (IPR000618)
Linkouts
Synonyms & Secondary IDs ( 4 )
Reported As
Symbol Synonym	L3CP6 (Chihara and Kimbrell, 1986) LCP6 (Charles, 1997.1.6, Charles, 1997.1.6, Charles et al., 1998, Chihara et al., 1982, Karouzou et al., 2007) Lcp6
Name Synonym	Larval cuticle protein 6
Secondary FlyBase IDs
References ( 15 )
Research paper	Anholt and Mackay, 2001, Behav. Genet. 31(1): 17--27 The genetic architecture of odor-guided behavior in Drosophila melanogaster. [FBrf0138231] Charles et al., 1998, Insect Biochem. Mol. Biol. 28(3): 131--138 Identification of proteins and developmental expression of RNAs encoded by the 65A cuticle protein gene cluster in Drosophila melanogaster. [FBrf0102898] Chihara and Kimbrell, 1986, Genetics 114: 393--404 The cuticle proteins of Drosophila melanogaster: genetic localization of a second cluster of third-instar genes. [FBrf0044447] Silvert et al., 1984, Biochemistry 23(24): 5767--5774 Pupal and larval cuticle proteins of Drosophila melanogaster. [FBrf0040382] Chihara et al., 1982, Dev. Biol. 89(2): 379--388 The cuticle proteins of Drosophila melanogaster: stage specificity. [FBrf0037866] Fristrom et al., 1978, Biochemistry 17(19): 3917--3924 The procuticle of Drosophila: heterogeneity of urea-soluble proteins. [FBrf0031088]
Supplementary material	Karouzou et al., 2007, Insect Biochem. Mol. Biol. 37(8): Tables S2-S5. [FBrf0200186]
Personal communication to FlyBase	FlyBase Curators et al., 2004-, Gene Ontology annotation in FlyBase through association of InterPro records with GO terms. Gene Ontology annotation in FlyBase through association of InterPro records with GO terms. [FBrf0174215] Bayraktaroglu, 2000.4.7, Annotation identities: Category 1. Annotation identities: Category 1. [FBrf0126708]
Abstract	Charles et al., 1996, A. Dros. Res. Conf. 37: 287 New family of larval cuticle protein genes of Drosophila: structure and expression of six clustered genes. [FBrf0084849]
FlyBase analysis	FlyBase, 1992-, FlyBase curation. FlyBase curation. [FBrf0105495]
DNA/RNA sequence record	Charles, 1997.1.6, GenBank/EMBL/DDBJ: U84757 Drosophila melanogaster putative cuticle protein LCP6 (LCP6) mRNA, complete cds. [FBrf0113743] Charles, 1997.1.6, GenBank/EMBL/DDBJ: U84756 Drosophila melanogaster putative cuticle protein LCP6 (LCP6) mRNA, complete cds. [FBrf0113742]
Book	Lindsley and Zimm, 1992, The Genome of Drosophila melanogaster. The Genome of Drosophila melanogaster. [FBrf0066905]
Thesis	del Puerto, 1985, M.S. Thesis, University of San Francisco, CA: Drosophila species (Diptera, Drosophilidae) last larval instar cuticle protein patterns and their use as an electrophoretic key; and, Genetic variation in third larval instar cuticle proteins of Drosophila melanogaster. [FBrf0069221]