Gene Dmel\ld

FlyGene Wiki Help Close All Open All

General Information

Symbol

Dmel\ld

Species

D. melanogaster

Name

loboid

Annotation symbol

Feature type

gene

FlyBase ID

FBgn0002541

Gene Model Status

Unannotated

Stock availability

4 publicly available

Genomic Location

Chromosome (arm)

Recombination map

3-102

Cytogenetic map

Sequence location

Summary Information

Automatically generated summary

See sections below for more information

The gene loboid is referred to in FlyBase by the symbol Dmel\ld (FBgn0002541). It is a gene from Drosophila melanogaster. Its molecular function is unknown. The biological processes in which it is involved are not known. 3 alleles are reported. The phenotypes of these alleles are annotated with: eye; ommatidium. It has no annotated transcripts. Gene has not been localized to the genome sequence.

User Contributed Data

Beta version, feedback welcome

Phenotypic Description from the Red Book (Lindsley & Zimm 1992)

Gene/Allele symbols may differ from current usage

ld: loboid

Eyes resemble L/+. Malformation of eyes ranges from slight dorsoventral seam across middle of eye to a more extreme effect in which growth of anterior part is completely inhibited in most-extreme cases. Antenna-like outgrowth frequent where growth of eyes is suppressed. Tends to overlap wild type. In the presence of a sex-linked modifier, opht [opht; ld designated ldoph by Kobel (1968, Genetica 39: 329-44)] ld flies show homeotic transformation of eye to wing tissue (Ouweneel, 1969, Wilhelm Roux's Arch. Entwicklungsmech. Org. 164: 1-114 and 14-36; 1970, 166: 76-88; 1970, Genetica 41: 1-20). RK3.

*ldeyr: loboid-eyes reduced

Eyes vary from normal to absence of ommatidia. Shows some degree of dominance; many heterozygotes have some eye abnormality, usually a nick in anterior region of one or both eyes; an abnormal growth of wing tissue may be associated with the nick. ldeyr; ey4 flies have very small heads, usually without ommatidia. Viability greatly reduced. RK2.

Recent Updates

Description

What does this section display?

This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms).

What does this section not display?

This section does not currently display links that were removed or gene model changes.

Update Feed

Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.

FB2013_03

FB2013_02

All updates

Click here to see a list of all updates to this record from FB2010_08 and on.

Detailed Mapping Data

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

Experimentally Determined Recombination Data

Location

3-100

(Curry, 1939, Edmondson, 1952)

3-102

Left of (cM)

(Lewis, 1956)

Right of (cM)

(Lewis, 1956)

Notes

Maps to the right of the right break of In(3R)P.

(Curry, 1939)

Gene Model & Products

Comments on Gene Model

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Associated CDS (aa)

Additional Transcript Data & Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

RefSeq ID

GenBank protein

Additional Polypeptide Data & Comments

Reported size (kDa)

Comments

External Data

Linkouts

Crossreferences

Sequences Consistent with the Gene Model

DDBJ /
EMBL /
GenBank

DNA sequence

Protein sequence

Name

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Mapped Features

Type

Symbol & Location

Additional Notes

References

External Data

Linkouts

Crossreferences

Expression Data

Transcript Expression

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

Additional Descriptive Data

Marker for

Subcellular Localization (GO Cellular Component)

CV term

Evidence

References

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

Reference

See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.

FlyAtlas Anatomy Microarray

modENCODE Anatomy RNA-Seq

modENCODE Development RNA-Seq

modENCODE Cell Lines RNA-Seq

modENCODE Treatments RNA-Seq

Expression Clusters

External Data & Images

Linkouts

Alleles & Phenotypes

Summary of Allele Phenotypes

Lethality

Allele

viable | reduced

ld^eyr

Other Phenotypes

Allele

visible

ld¹

visible | dominant | partially

ld^eyr

Phenotype manifest in

Allele

eye

ommatidium

ld^eyr

Classical Alleles ( 3 )

For All Classical Alleles Show

Allele of ld	Mutagen	Stocks	Known lesion
ld¹	spontaneous	4	--
ld^52a	spontaneous	0	--
ld^eyr	cupric sulfate	0	--

Alleles Carried on Transgenic Constructs ( 0 )

For All Alleles Carried on Transgenic Constructs Show

Allele of ld	Class	Mutagen	Stocks	Known lesion

Aneuploid Aberrations

Not disrupted in

In(3R)P

(Curry, 1939)

Transgenic Constructs & Insertions

Transgenic Constructs

Type of construct

Name

Expression data

Insertions

Type of insertions

Name

Expression data

Gene Ontology: Function, Process & Cellular Component ( 0 unique terms )

Terms Based on Experimental Evidence ( 0 terms )

Terms Based on Predictions or Assertions ( 0 terms )

Sequence Ontology: Class of Gene

gene

Interactions & Pathways

Summary of Physical Interactions

Summary of Genetic Interactions

Interacts with

Please look at the allele data for full details of the genetic interactions

ld allele

Gene

References

ld¹

opht

(Ouweneel, 1970)

unspecified

External Data

Linkouts

DroID - A comprehensive database of gene and protein interactions.

•

FBgn0002541

InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets.

•

45893

Orthologs

OrthoDB Orthologs (0) - based on analysis using Dmel annotation version 5.41

OrthoDB Ortholog Groups

OrthoDB orthology group searches

(Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288)

Drosophila inclusive ortholog search

No orthologs identified

Dipteran inclusive ortholog search

No orthologs identified

Insect inclusive ortholog search

No orthologs identified

Arthropod inclusive ortholog search

No orthologs identified

Metazoa inclusive ortholog search

No orthologs identified

Orthologs in Drosophila Species (None identified)

No orthologies identified

Orthologs in non-Drosophila Dipterans (None identified)

No non-Drosophilid orthologies identified

Orthologs in non-Dipteran Insects (None identified)

No non-Dipteran orthologies identified

Orthologs in non-Insect Arthropods (None identified)

No non-Insect Arthropod orthologies identified

Orthologs in non-Arthropod Metazoa (None identified)

No non-Arthropod Metazoa orthologies identified

Human Orthologs (0)

Gene

OMIM

HGNC

AAA Orthologs (0) based on analysis using Dmel annotation version 4.3

No orthologs identified

Stocks & Reagents

Stocks Listed in FlyBase ( 4 )

Bloomington

530

ld¹

475

e⁴ wo¹ ro¹ rsd¹ ca¹ ld¹ bv¹/In(3R)C, Sb¹ e¹ l(3)e¹

Kyoto

105965

ld¹

105931

e⁴ wo¹ ro¹ rsd¹ ca¹ ld¹ bv¹/In(3R)C, Sb¹ sprd¹ e¹ l(3)e¹

Genomic Clones ( 0 )

cDNA Clones ( 0 )

cDNA Clones, Fully Sequenced

BDGP DGC clones

Other clones

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi & Array Information

Linkouts

GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents

•

45893

Antibody Information

Other Information

Discoverer

Curry, Jan. 1939.

Etymology

Identification

Relationship to Other Genes

Source for database identity of

Source for database merge of

Additional comments

Other Comments

The abnormal ld phenotype is due to a developmental defect: late occurring defects. Adult eyes are slightly rough, eye disc appears normal.

(Renfranz and Benzer, 1989)

External Crossreferences & Linkouts

Sequence Crossreferences

Other Crossreferences

Linkouts

DroID - A comprehensive database of gene and protein interactions.

•

FBgn0002541

GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents

•

45893

InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets.

•

45893

Synonyms & Secondary IDs ( 2 )

Reported As

Symbol Synonym

Name Synonym

loboid

Secondary FlyBase IDs

References ( 16 )

Research paper

Komma et al., 1991, EMBO J. 10(12): 419--424: Separation of meiotic and mitotic effects of claret non-disjunctional on chromosome segregation in Drosophila. [FBrf0053896]
Lai et al., 1991, Mech. Dev. 34: 123--134: The embryonic expression patterns of zfh-1 and zfh-2, two Drosophila genes encoding novel zinc-finger homeodomain proteins. [FBrf0054608]
Renfranz and Benzer, 1989, Dev. Biol. 136(2): 411--429: Monoclonal antibody probes discriminate early and late mutant defects in development of the Drosophila retina. [FBrf0049495]
Postlethwait, 1974, Dev. Biol. 36: 212--217: Development of the temperature-sensitive homoeotic mutant ophthalmoptera of Drosophila melanogaster. [FBrf0026168]
Ouweneel, 1970, Genetica 41: 1--20: Genetic analysis of loboid-ophthalmoptera, a homoeotic strain in Drosophila melanogaster. [FBrf0021520]
Ouweneel, 1970, Roux Arch. EntwMech. Organ. 166: 76--88: Developmental capacities of young and mature, wild-type and opht eye imaginal discs in Drosophila melanogaster. [FBrf0021963]
Ouweneel, 1969, Roux Arch. EntwMech. Organ. 164: 1--14: Morphology and development of loboid-ophthalmoptera, a homoeotic strain in Drosophila melanogaster. [FBrf0020951]
Ouweneel, 1969, Roux Arch. EntwMech. Organ. 164: 15--36: Influence of environmental factors on the homoeotic effect of loboid-ophthalmoptera in Drosophila melanogaster. [FBrf0020952]
Kobel, 1968, Genetica 39: 329--344: Homoeotische flugelbildung durch das loboid-allel 'ophthalmoptera' (ldoph) bei Drosophila melanogaster. [FBrf0019528]
Edwards and Gardner, 1966, Genetics 53: 785--798: Genetics of the eyes-reduced mutant of Drosophila melanogaster, with special reference to homoeosis and eyelessness. [FBrf0017867]
Edwards and Gardner, 1963, D. I. S. 37: 47: [New mutants report.] [FBrf0063412]
Lewis, 1956, D. I. S. 30: 130: Addition and corrections to the list of mutants in the work of Bridges-Brehme (1944). [FBrf0010688]
Edmondson, 1952, D. I. S. 26: 60--62: [New mutants report.] [FBrf0063411]
Spassky and Dobzhansky, 1950, Heredity 4: 201--215: Comparative genetics of Drosophila willistoni. [FBrf0007861]
Curry, 1939, D. I. S. 12: 45--47: [New mutants report.] [FBrf0063388]

Book

Lindsley and Zimm, 1992, The Genome of Drosophila melanogaster.: The Genome of Drosophila melanogaster. [FBrf0066905]