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Gene Dmel\lds

General Information
Symbol	Dmel\lds	Species	D. melanogaster
Name	lodestar	Annotation symbol	CG2684
Feature type	protein_coding_gene	FlyBase ID	FBgn0002542
Gene Model Status	Current	Stock availability	13 publicly available
Also Known As	Horka
Genomic Location
Chromosome (arm)	3R	Recombination map	3-47.8
Cytogenetic map	84E5-84E5	Sequence location	3R:3,746,156..3,750,211 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene lodestar is referred to in FlyBase by the symbol Dmel\lds (CG2684, FBgn0002542). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: DNA-dependent ATPase activity. There is experimental evidence that it is involved in the biological process: female meiosis; transcription termination, DNA-dependent; microtubule anchoring at centrosome; spermatogenesis. 27 alleles are reported. The phenotypes of these alleles are annotated with: onion stage spermatid; trichogen cell; centrosome; individualization stage spermatid. It has one annotated transcript and one annotated polypeptide. Protein features are: DEAD-like helicase; Helicase, C-terminal; SNF2-related. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of low expression. Peak expression observed within 00-06 hour embryonic stages, in adult female stages. Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: larval central nervous system, adult ovary, adult testis. Comments on Affy2 ProbeSet: ProbeSet 1634695_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of lds. Gene sequence location is 3R:3746156..3750211.
Phenotypic Description from the Red Book (Lindsley & Zimm 1992)
Gene/Allele symbols may differ from current usage	lds: lodestar Maternal. In nuclear cycles 9-10, multiple complex anaphase spindles share several centrosomes. Multiple groups of chromosomes are often directed to same pole. Elongated polyploid nuclei develop. Mitotic abnormalities in larval brain cells (Gatti).
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2011_10
FB2012_01	Sequence features BKN45004 BKN22579 HFA16988
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 84E5-84E5   Limits computationally determined from genome sequence between P{EP}EP3060EP3060 and P{PZ}grn05930
Experimentally Determined Cytological Location
Cytogenetic map Notes References 87B-87B     (Szabad et al., 1995) 84D13-84D14   (determined by in situ hybridisation)   (Girdham and Glover, 1991)
Experimentally Determined Recombination Data
Location	3-47 (Tearle and Nusslein-Volhard, 1987) 3-47.8
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\lds for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) lds-RA FBtr0081758  NM_080111   3538   1061
Additional Transcript Data & Comments
Reported size (kB)	3.8, 3.5 (northern blot) (Girdham and Glover, 1991)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein lds-PA   FBpp0081255   118.4   1061   6.61     NP_524850   AAF54167
Additional Polypeptide Data & Comments
Reported size (kDa)	974 (aa); 155 (kD observed) (Girdham and Glover, 1991)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • SNF2-related (IPR000330) Helicase, C-terminal (IPR001650) DEAD-like helicase (IPR014001)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA440836   AA440837   AE014297 AAF54167   AY118417 AAM48446   BG639726   BI487133   BP555774   BQ103088   BT015973 AAV36858   CO180696   CO191295   CO268492   CO301597   CO311139   CO317790   CO326756   CO333398   CZ478726   EC064744   EC085463   EC242997   EC251862   EV598802   X62629 CAA44496
UniProtKB/Swiss-Prot	P34739
UniProtKB/TrEMBL	Q8MT27
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
northern blot Stage Tissue/Position (including subcellular localization) Reference embryonic stage -- adult stage     (Girdham and Glover, 1991) oogenesis & adult stage | female   ovary   (Girdham and Glover, 1991)
Additional Descriptive Data
	A major 3.5kb lds transcript is detected throughout development and is abundant in early embryos and adult females. A minor 3.8kb lds transcript is detected in early embryos and in females. In females, lds transcripts are ovary-specific. (Girdham and Glover, 1991)
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
Additional Descriptive Data
	The lds protein is cytoplasmic at interphase, rapidly enters the nucleus early in prophase, is restricted to the region enclosed by the spindle envelope in metaphase and anaphase, and by telophase is contained entirely in the reforming nucleus. (Girdham and Glover, 1991)
Marker for
Subcellular Localization
CV Term	nucleus cytoplasm (Girdham and Glover, 1991)
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0002542    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0002542 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of low expression. Peak expression observed within 00-06 hour embryonic stages, in adult female stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0002542 expression level Developmental Stage   Expression Level embryo 00-02hr    6039 embryo 02-04hr    1366 embryo 04-06hr    3857 embryo 06-08hr    3460 embryo 08-10hr    2072 embryo 10-12hr    926 embryo 12-14hr    512 embryo 14-16hr    244 embryo 16-18hr    178 embryo 18-20hr    153 embryo 20-22hr    112 embryo 22-24hr    133 larva L1    294 larva L2    317 larva L3 12hr old    273 larva L3 puffstage 1-2    504 larva L3 puffstage 3-6    914 larva L3 puffstage 7-9    1165 white prepupae new    1163 white prepupae 12hr    1339 white prepupae 24hr    1359 pupae 2d postWPP    794 pupae 3d postWPP    425 pupae 4d postWPP    359 adult male 01day    535 adult male 05day    860 adult male 30day    636 adult female 01day    1653 adult female 05day    4068 adult female 30day    3969 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (6039) embryo 02-04hr  (1366) embryo 04-06hr  (3857) embryo 06-08hr  (3460) embryo 08-10hr  (2072) embryo 10-12hr  (926) embryo 12-14hr  (512) embryo 14-16hr  (244) embryo 16-18hr  (178) embryo 18-20hr  (153) embryo 20-22hr  (112) embryo 22-24hr  (133) larva L1  (294) larva L2  (317) larva L3 12hr old  (273) larva L3 puffstage 1-2  (504) larva L3 puffstage 3-6  (914) larva L3 puffstage 7-9  (1165) white prepupae new  (1163) white prepupae 12hr  (1339) white prepupae 24hr  (1359) pupae 2d postWPP  (794) pupae 3d postWPP  (425) pupae 4d postWPP  (359) adult male 01day  (535) adult male 05day  (860) adult male 30day  (636) adult female 01day  (1653) adult female 05day  (4068) adult female 30day  (3969) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (6039) embryo 02-04hr    1366 embryo 04-06hr  (3857) embryo 06-08hr  (3460) embryo 08-10hr  (2072) embryo 10-12hr    926 embryo 12-14hr    512 embryo 14-16hr    244 embryo 16-18hr    178 embryo 18-20hr    153 embryo 20-22hr    112 embryo 22-24hr    133 larva L1    294 larva L2    317 larva L3 12hr old    273 larva L3 puffstage 1-2    504 larva L3 puffstage 3-6    914 larva L3 puffstage 7-9    1165 white prepupae new    1163 white prepupae 12hr    1339 white prepupae 24hr    1359 pupae 2d postWPP    794 pupae 3d postWPP    425 pupae 4d postWPP    359 adult male 01day    535 adult male 05day    860 adult male 30day    636 adult female 01day  (1653) adult female 05day  (4068) adult female 30day  (3969) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    6039 embryo 02-04hr    1366 embryo 04-06hr    3857 embryo 06-08hr    3460 embryo 08-10hr    2072 embryo 10-12hr    926 embryo 12-14hr    512 embryo 14-16hr    244 embryo 16-18hr    178 embryo 18-20hr    153 embryo 20-22hr    112 embryo 22-24hr    133 larva L1    294 larva L2    317 larva L3 12hr old    273 larva L3 puffstage 1-2    504 larva L3 puffstage 3-6    914 larva L3 puffstage 7-9    1165 white prepupae new    1163 white prepupae 12hr    1339 white prepupae 24hr    1359 pupae 2d postWPP    794 pupae 3d postWPP    425 pupae 4d postWPP    359 adult male 01day    535 adult male 05day    860 adult male 30day    636 adult female 01day    1653 adult female 05day    4068 adult female 30day    3969 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    6039 embryo 02-04hr    1366 embryo 04-06hr    3857 embryo 06-08hr    3460 embryo 08-10hr    2072 embryo 10-12hr    926 embryo 12-14hr    512 embryo 14-16hr    244 embryo 16-18hr    178 embryo 18-20hr    153 embryo 20-22hr    112 embryo 22-24hr    133 larva L1    294 larva L2    317 larva L3 12hr old    273 larva L3 puffstage 1-2    504 larva L3 puffstage 3-6    914 larva L3 puffstage 7-9    1165 white prepupae new    1163 white prepupae 12hr    1339 white prepupae 24hr    1359 pupae 2d postWPP    794 pupae 3d postWPP    425 pupae 4d postWPP    359 adult male 01day    535 adult male 05day    860 adult male 30day    636 adult female 01day    1653 adult female 05day    4068 adult female 30day    3969 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0002542 expression level Developmental Stage   Expression Level embryo 00-02hr    6039 embryo 02-04hr    1366 embryo 04-06hr    3857 embryo 06-08hr    3460 embryo 08-10hr    2072 embryo 10-12hr    926 embryo 12-14hr    512 embryo 14-16hr    244 embryo 16-18hr    178 embryo 18-20hr    153 embryo 20-22hr    112 embryo 22-24hr    133 larva L1    294 larva L2    317 larva L3 12hr old    273 larva L3 puffstage 1-2    504 larva L3 puffstage 3-6    914 larva L3 puffstage 7-9    1165 white prepupae new    1163 white prepupae 12hr    1339 white prepupae 24hr    1359 pupae 2d postWPP    794 pupae 3d postWPP    425 pupae 4d postWPP    359 adult male 01day    535 adult male 05day    860 adult male 30day    636 adult female 01day    1653 adult female 05day    4068 adult female 30day    3969 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (6039) embryo 02-04hr  (1366) embryo 04-06hr  (3857) embryo 06-08hr  (3460) embryo 08-10hr  (2072) embryo 10-12hr  (926) embryo 12-14hr  (512) embryo 14-16hr  (244) embryo 16-18hr  (178) embryo 18-20hr  (153) embryo 20-22hr  112 embryo 22-24hr  133 larva L1  (294) larva L2  (317) larva L3 12hr old  (273) larva L3 puffstage 1-2  (504) larva L3 puffstage 3-6  (914) larva L3 puffstage 7-9  (1165) white prepupae new  (1163) white prepupae 12hr  (1339) white prepupae 24hr  (1359) pupae 2d postWPP  (794) pupae 3d postWPP  (425) pupae 4d postWPP  (359) adult male 01day  (535) adult male 05day  (860) adult male 30day  (636) adult female 01day  (1653) adult female 05day  (4068) adult female 30day  (3969) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (6039) embryo 02-04hr    1366 embryo 04-06hr  (3857) embryo 06-08hr  (3460) embryo 08-10hr  2072 embryo 10-12hr    926 embryo 12-14hr    512 embryo 14-16hr    244 embryo 16-18hr    178 embryo 18-20hr    153 embryo 20-22hr    112 embryo 22-24hr    133 larva L1    294 larva L2    317 larva L3 12hr old    273 larva L3 puffstage 1-2    504 larva L3 puffstage 3-6    914 larva L3 puffstage 7-9    1165 white prepupae new    1163 white prepupae 12hr    1339 white prepupae 24hr    1359 pupae 2d postWPP    794 pupae 3d postWPP    425 pupae 4d postWPP    359 adult male 01day    535 adult male 05day    860 adult male 30day    636 adult female 01day  1653 adult female 05day  (4068) adult female 30day  (3969) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    6039 embryo 02-04hr    1366 embryo 04-06hr    3857 embryo 06-08hr    3460 embryo 08-10hr    2072 embryo 10-12hr    926 embryo 12-14hr    512 embryo 14-16hr    244 embryo 16-18hr    178 embryo 18-20hr    153 embryo 20-22hr    112 embryo 22-24hr    133 larva L1    294 larva L2    317 larva L3 12hr old    273 larva L3 puffstage 1-2    504 larva L3 puffstage 3-6    914 larva L3 puffstage 7-9    1165 white prepupae new    1163 white prepupae 12hr    1339 white prepupae 24hr    1359 pupae 2d postWPP    794 pupae 3d postWPP    425 pupae 4d postWPP    359 adult male 01day    535 adult male 05day    860 adult male 30day    636 adult female 01day    1653 adult female 05day    4068 adult female 30day    3969 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    6039 embryo 02-04hr    1366 embryo 04-06hr    3857 embryo 06-08hr    3460 embryo 08-10hr    2072 embryo 10-12hr    926 embryo 12-14hr    512 embryo 14-16hr    244 embryo 16-18hr    178 embryo 18-20hr    153 embryo 20-22hr    112 embryo 22-24hr    133 larva L1    294 larva L2    317 larva L3 12hr old    273 larva L3 puffstage 1-2    504 larva L3 puffstage 3-6    914 larva L3 puffstage 7-9    1165 white prepupae new    1163 white prepupae 12hr    1339 white prepupae 24hr    1359 pupae 2d postWPP    794 pupae 3d postWPP    425 pupae 4d postWPP    359 adult male 01day    535 adult male 05day    860 adult male 30day    636 adult female 01day    1653 adult female 05day    4068 adult female 30day    3969 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0002542    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0002542 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: larval central nervous system, adult ovary, adult testis. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0002542 expression level Tissue   Expression Level Larval Central Nervous System    183.5 Larval Midgut no informative data Larval Hindgut    34.9 Larval Malpighian Tubules    36.7 Larval Fat Body    54.2 Larval Salivary Gland    36.8 Larval Trachea    95.525 Larval Carcass    54.95 Adult Head no informative data Adult Eye    14.25 Adult Brain    9.1 Adult Thoracic-Abdominal Ganglion no informative data Adult Crop    9.5 Adult Midgut no informative data Adult Hindgut    15.2 Adult Malpighian Tubules no informative data Adult Fat Body no informative data Adult Salivary Gland no informative data Adult Heart    12.125 Adult VirginFemale Spermatheca    20.7 Adult InseminatedFemale Spermatheca    22.4 Adult Ovary    415.3 Adult Testis    176.2 Adult Male Accessory Gland    6.1 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    183.5 Larval Midgut no informative data Larval Hindgut    34.9 Larval Malpighian Tubules    36.7 Larval Fat Body    54.2 Larval Salivary Gland    36.8 Larval Trachea    95.525 Larval Carcass    54.95 Adult Head no informative data Adult Eye    14.25 Adult Brain    9.1 Adult Thoracic-Abdominal Ganglion no informative data Adult Crop    9.5 Adult Midgut no informative data Adult Hindgut    15.2 Adult Malpighian Tubules no informative data Adult Fat Body no informative data Adult Salivary Gland no informative data Adult Heart    12.125 Adult VirginFemale Spermatheca    20.7 Adult InseminatedFemale Spermatheca    22.4 Adult Ovary    415.3 Adult Testis    176.2 Adult Male Accessory Gland    6.1 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    183.5 Larval Midgut no informative data Larval Hindgut    34.9 Larval Malpighian Tubules    36.7 Larval Fat Body    54.2 Larval Salivary Gland    36.8 Larval Trachea    95.525 Larval Carcass    54.95 Adult Head no informative data Adult Eye    14.25 Adult Brain    9.1 Adult Thoracic-Abdominal Ganglion no informative data Adult Crop    9.5 Adult Midgut no informative data Adult Hindgut    15.2 Adult Malpighian Tubules no informative data Adult Fat Body no informative data Adult Salivary Gland no informative data Adult Heart    12.125 Adult VirginFemale Spermatheca    20.7 Adult InseminatedFemale Spermatheca    22.4 Adult Ovary    415.3 Adult Testis    176.2 Adult Male Accessory Gland    6.1 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    183.5 Larval Midgut no informative data Larval Hindgut    34.9 Larval Malpighian Tubules    36.7 Larval Fat Body    54.2 Larval Salivary Gland    36.8 Larval Trachea    95.525 Larval Carcass    54.95 Adult Head no informative data Adult Eye    14.25 Adult Brain    9.1 Adult Thoracic-Abdominal Ganglion no informative data Adult Crop    9.5 Adult Midgut no informative data Adult Hindgut    15.2 Adult Malpighian Tubules no informative data Adult Fat Body no informative data Adult Salivary Gland no informative data Adult Heart    12.125 Adult VirginFemale Spermatheca    20.7 Adult InseminatedFemale Spermatheca    22.4 Adult Ovary    415.3 Adult Testis    176.2 Adult Male Accessory Gland    6.1 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0002542 expression level Tissue   Expression Level Larval Central Nervous System    183.5 Larval Midgut no informative data Larval Hindgut    34.9 Larval Malpighian Tubules    36.7 Larval Fat Body    54.2 Larval Salivary Gland    36.8 Larval Trachea    95.525 Larval Carcass    54.95 Adult Head no informative data Adult Eye    14.25 Adult Brain    9.1 Adult Thoracic-Abdominal Ganglion no informative data Adult Crop    9.5 Adult Midgut no informative data Adult Hindgut    15.2 Adult Malpighian Tubules no informative data Adult Fat Body no informative data Adult Salivary Gland no informative data Adult Heart    12.125 Adult VirginFemale Spermatheca    20.7 Adult InseminatedFemale Spermatheca    22.4 Adult Ovary    415.3 Adult Testis    176.2 Adult Male Accessory Gland    6.1 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    183.5 Larval Midgut no informative data Larval Hindgut    34.9 Larval Malpighian Tubules    36.7 Larval Fat Body    54.2 Larval Salivary Gland    36.8 Larval Trachea    95.525 Larval Carcass    54.95 Adult Head no informative data Adult Eye    14.25 Adult Brain    9.1 Adult Thoracic-Abdominal Ganglion no informative data Adult Crop    9.5 Adult Midgut no informative data Adult Hindgut    15.2 Adult Malpighian Tubules no informative data Adult Fat Body no informative data Adult Salivary Gland no informative data Adult Heart    12.125 Adult VirginFemale Spermatheca    20.7 Adult InseminatedFemale Spermatheca    22.4 Adult Ovary    415.3 Adult Testis    176.2 Adult Male Accessory Gland    6.1 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    183.5 Larval Midgut no informative data Larval Hindgut    34.9 Larval Malpighian Tubules    36.7 Larval Fat Body    54.2 Larval Salivary Gland    36.8 Larval Trachea    95.525 Larval Carcass    54.95 Adult Head no informative data Adult Eye    14.25 Adult Brain    9.1 Adult Thoracic-Abdominal Ganglion no informative data Adult Crop    9.5 Adult Midgut no informative data Adult Hindgut    15.2 Adult Malpighian Tubules no informative data Adult Fat Body no informative data Adult Salivary Gland no informative data Adult Heart    12.125 Adult VirginFemale Spermatheca    20.7 Adult InseminatedFemale Spermatheca    22.4 Adult Ovary    415.3 Adult Testis    176.2 Adult Male Accessory Gland    6.1 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    183.5 Larval Midgut no informative data Larval Hindgut    34.9 Larval Malpighian Tubules    36.7 Larval Fat Body    54.2 Larval Salivary Gland    36.8 Larval Trachea    95.525 Larval Carcass    54.95 Adult Head no informative data Adult Eye    14.25 Adult Brain    9.1 Adult Thoracic-Abdominal Ganglion no informative data Adult Crop    9.5 Adult Midgut no informative data Adult Hindgut    15.2 Adult Malpighian Tubules no informative data Adult Fat Body no informative data Adult Salivary Gland no informative data Adult Heart    12.125 Adult VirginFemale Spermatheca    20.7 Adult InseminatedFemale Spermatheca    22.4 Adult Ovary    415.3 Adult Testis    176.2 Adult Male Accessory Gland    6.1 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut no informative data Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head no informative data Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion no informative data Adult Crop     Adult Midgut no informative data Adult Hindgut     Adult Malpighian Tubules no informative data Adult Fat Body no informative data Adult Salivary Gland no informative data Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass no informative data FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    no informative data   NA  Eye    14.25   NA  Brain    9.1   183.5  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    no informative data   NA  Crop    9.5   no informative data  Midgut    no informative data   34.9  Hindgut    15.2   36.7  Malpighian Tubules    no informative data   54.2  Fat Body    no informative data   36.8  Salivary Gland    no informative data   NA  Heart    12.125   95.525  Trachea    NA   NA  VirginFemale Spermatheca    20.7   NA  InseminatedFemale Spermatheca    22.4   NA  Ovary    415.3   NA  Testis    176.2   NA  Male Accessory Gland    6.1   54.95  Carcass    no informative data modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_06
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0002542 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG2684-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal | dominant | embryonic stage | maternal effect ldsHor-D lethal | embryonic stage | maternal effect ldsHD5.1 ldsHD5.5 ldsHor-D lethal | pupal stage, with Scer\GAL4pnr-MD237 ldsGD4508 semi-lethal | pupal stage, with Scer\GAL4pnr-MD237 ldsGD4508 Sterility Allele female sterile ldsHD5.1 ldsHD5.5 female sterile (with Df(3R)dsx15) ldsHor-D ldshor-rvP2 female sterile (with lds3) ldsHor-D ldshor-rvP2 female sterile (with lds4) ldshor-rvP2 female sterile (with ldsHor-D) lds3 female sterile (with ldshor-rvP2) lds3 lds4 female sterile | dominant ldsHor-D male sterile (with lds3) ldshor-rvP2 male sterile (with ldshor-rvP2) lds3 male sterile | partially (with Df(3R)dsx15) ldsHor-D ldshor-rvP2 Other Phenotypes Allele meiotic cell cycle defective ldsHor-D mitotic cell cycle defective | dominant | paternal effect ldsHor-D mitotic cell cycle defective | non-rescuable maternal effect | recessive lds1 lds3 lds4 lds352-16 visible, with Scer\GAL4pnr-MD237 ldsGD4508 wild-type lds+tA Phenotype manifest in Allele centrosome ldshor-rvP2 chromatin & mitotic anaphase lds079-2 female pronucleus | maternal effect ldsHor-D individualization stage spermatid ldshor-rvP2 male pronucleus | maternal effect ldsHor-D mitosis & nuclear chromosome & embryo ldsunspecified nucleus | embryonic stage ldsunspecified onion stage spermatid ldshor-rvP2 spindle | embryonic stage ldsunspecified trichogen cell, with Scer\GAL4pnr-MD237 ldsGD4508
Classical Alleles ( 21 )
For All Classical Alleles Show
Allele of lds Class Mutagen Stocks Known lesion ldsHor-D antimorphic allele - genetic evidence, gain of function allele ethyl methanesulfonate 5 Yes lds1 ethyl methanesulfonate 2 -- lds5-HA-1872 1 -- ldsA190 1 -- ldse00889 piggyBac transposase 1 -- lds079-2 0 -- lds2 0 -- lds352-16 ethyl methanesulfonate 0 -- lds3 ethyl methanesulfonate 0 -- lds4 ethyl methanesulfonate 0 -- ldshor-rvE1 ethyl methanesulfonate 0 -- ldshor-rvP1 PM hybrid dysgenesis 0 -- ldshor-rvP2 loss of function allele PM hybrid dysgenesis 0 Yes ldshor-rvP3 PM hybrid dysgenesis 0 Yes ldshor-rvP4 PM hybrid dysgenesis 0 -- ldshor-rvP5 PM hybrid dysgenesis 0 -- ldshor-rvP6 PM hybrid dysgenesis 0 -- ldshor-rvP7 PM hybrid dysgenesis 0 -- ldshor-rvP8 PM hybrid dysgenesis 0 -- ldshor-rvP9 PM hybrid dysgenesis 0 Yes ldsunspecified 0 --
Alleles Carried on Transgenic Constructs ( 6 )
For All Alleles Carried on Transgenic Constructs Show
Allele of lds Class Mutagen Stocks Known lesion ldsGD4508 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes ldsHMS01389 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes lds+tA in vitro construct - genomic fragment 0 -- ldsHD5.1 in vitro construct - amino acid replacement 0 Yes ldsHD5.5 in vitro construct - amino acid replacement 0 Yes ldst5.1 in vitro construct - genomic fragment 0 Yes
Aneuploid Aberrations
Duplicated in	Dp(3;3)Antp73b-rv8 (Szalontai et al., 2009)
Disrupted in	Df(3R)dsx2D (Szalontai et al., 2009) Df(3R)dsx5 (Szalontai et al., 2009) Df(3R)dsx15 (Szalontai et al., 2009)
Not disrupted in	Df(3R)Antp17 (Szalontai et al., 2009) Df(3R)CA1 (Szalontai et al., 2009) Df(3R)p-XT103 (Szalontai et al., 2009)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD4508} NA P{TRiP.HMS01389} NA characterization construct P{lds.+5.1} NA P{lds.HD5.1} NA P{lds.HD5.5} NA P{pW8A} NA
Insertions
	Type of insertions Name Expression data miscellaneous insertions P{}ldshor-rvP1 NA P{}ldshor-rvP2 NA P{}ldshor-rvP3 NA P{}ldshor-rvP4 NA P{}ldshor-rvP5 NA P{}ldshor-rvP6 NA P{}ldshor-rvP7 NA P{}ldshor-rvP8 NA P{}ldshor-rvP9 NA P{RS5}lds5-HA-1872 NA PBac{5HPw+}ldsA190 NA PBac{RB}ldse00889 NA
Gene Ontology: Function, Process & Cellular Component ( 10 unique terms )
Terms Based on Experimental Evidence ( 5 terms )
Molecular Function
CV term Evidence References
DNA-dependent ATPase activity inferred from direct assay (Xie and Price, 1998)
Biological Process
CV term Evidence References
female meiosis inferred from mutant phenotype (Szalontai et al., 2009) microtubule anchoring at centrosome inferred from mutant phenotype (Szalontai et al., 2009) spermatogenesis inferred from mutant phenotype (Szalontai et al., 2009) transcription termination, DNA-dependent inferred from direct assay (Xie and Price, 1996)
Cellular Component ( 0 terms)
Terms Based on Predictions or Assertions ( 6 terms )
Molecular Function
CV term Evidence References
ATP binding inferred from electronic annotation with InterPro:IPR000330, InterPro:IPR001650 (FlyBase Curators et al., 2004-) DNA binding inferred from electronic annotation with InterPro:IPR000330 (FlyBase Curators et al., 2004-) DNA-dependent ATPase activity inferred from sequence or structural similarity with NCBI_gi:4507717 (FlyBase, 1992-) helicase activity inferred from electronic annotation with InterPro:IPR001650 (FlyBase Curators et al., 2004-)
Biological Process
CV term Evidence References
termination of RNA polymerase II transcription inferred from sequence or structural similarity with NCBI_gi:4507717 (FlyBase, 1992-)
Cellular Component
CV term Evidence References
nucleus non-traceable author statement (Swiss-Prot Project Members, 1994.2.1)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions lds allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 69962 DroID - A comprehensive database of gene and protein interactions. • FBgn0002542 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 45894
Orthologs
Genome-wide drosophilid orthologs	Dana\GF18453 Dere\GG14296 Dgri\GH17632 Dmoj\GI22534 Dper\GL23967 Dpse\GA15429 Dsec\GM10986 Dsim\GD19959 Dvir\GJ10137 Dwil\GK12953 Dyak\GE24955
Curated drosophilid orthologs	Dbuz\lds   Dpse\GA15429
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL006331-PA Aedes aegypti (mosquito) AGAP011966-PA Anopheles gambiae (mosquito) XP_393754.2 Apis mellifera (honey bee) XP_001948361.1 Acyrthosiphon pisum (pea aphid) At1g11100.1 Arabidopsis thaliana (wall cress) XP_001897732.1 Brugia malayi (roundworm nematode) BGIBMGA004879-PA Bombyx mori (silk worm) ENSBTAP00000033620 Bos taurus (bovine) CAL0000717 Candida albicans (a form of yeast) CN12449 Caenorhabditis brenneri (small nematode) CBP30169 Caenorhabditis briggsae (nematode) CE41936 Caenorhabditis elegans (worm) ENSCAFP00000014474 Canis familiaris (dog) CAGL0G09493g Candida glabrata (haploid yeast) ENSCINP00000025373 Ciona intestinalis (sea squirt) JA10430 Caenorhabditis japonica (nematode) CMR259C Cyanidioschyzon merolae (red alga) cn02471 Cryptococcus neoformans (yeast-like fungus) ENSCPOP00000000533 Cavia porcellus (guinea pig) RP26662 Caenorhabditis remanei (nematode) ENSCSAVP00000004793 Ciona savignyi (sedentary tunicate) 34418 Capitella spl (polychaete worm) DDB0233429 Dictyostelium discoideum (amoeba) DEHA2G18722g Debaryomyces Hansenii (yeast) 260126 Daphnia pulex (daphnia) ENSDARP00000032185 Danio rerio (zebra fish) ENSECAP00000010511 Equus caballus (horse) ENSGACP00000001756 Gymnopilus aculeatus (mushroom) ENSGALP00000036135 Gallus gallus (chicken) 95427 Hypsipyla robusta (cedar shoot borer) ENSP00000358478 Homo sapiens (human) ISCW002351-PA Ixodes scapularis (deer tick) KLLA0F17479g Kluyveromyces lactis (yeast) 232224 Lottia gigantea (owl limpet) LmjF25.0740 Leishmania major (virus) 24613 Monocosta brevicollis (choanoflagellate) ENSMODP00000028991 Monodelphis domestica (gray opossum) ENSMMUP00000022223 Macaca mulatta (rhesus monkey) ENSMUSP00000049465 Mus musculus (house mouse) 10347 Nematostella vectensis (starlet anemone) XP_001603076.1 Nasonia vitripennis (wasp) ENSOANP00000000967 Ornithorynchus anatinus (platypus) ENSORLP00000016100 Oryzias latipes (japanese killifish) LOC_Os01g57110.1 Oryza sativa (asian rice) MAL13P1.216 Plasmodium falciparum (protozoal parasite) PHUM004122-PA Pediculus humanus (human body louse) PP28884 Pristionchus pacificus (nematode) 105578 Physcomitrella patens (moss) ENSPPYP00000001139 Pongo pygmaeus (orangutan) 79594 Phytophthora ramorum (sudden oak death pathogen) 124722 Phytophthora sojae (root rot pathogen) 764977 Populus trichocarpa (black cottonwood) ENSPTRP00000001988 Pan troglodytes (chimpanzee) PVX_083065 Plasmodium vivax (protozoal parasite) ENSRNOP00000052989 Rattus norvegicus (norway rat) 5053814 Sorghum bicolor (sorghum) YOR191W Saccharomyces cerevisiae (budding yeast) SPBC23E6.02 Schizosaccharomyces pombe (fission yeast) SPBC582.10c Schizosaccharomyces pombe (fission yeast) XP_787293.2 Strongylocentrotus purpuratus (purple sea urchin) XP_969437.2 Tribolium castaneum (red flour beetle) Tc00.1047053506925.140 Trypanosoma cruzi (parasitic trypanosome) ENSTNIP00000018754 Tetraodon nigroviridis (green spotted pufferfish) 268889 Thalassiosira pseudonana (marine diatom) ENSTRUP00000039857 Takifugu rubripes (pufferfish Takifugu) 3825.m02825 Tetrahymena thermophila (ciliate protozoa) YALI0E04136g Yarrowia lipolytica (nonconventional yeast) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB11893 NV16517 NV14737 LH22019 LH25090 ISCW002351 FBgn0242049 FBgn0214962 FBgn0197425 FBgn0191442 FBgn0165932 FBgn0165931 JGI_V11_274784 JGI_V11_54578 JGI_V11_6632 JGI_V11_249322 JGI_V11_35494 JGI_V11_308061 FBgn0075446 FBgn0161557 FBgn0145262 FBgn0125102 FBgn0106557 FBgn0095471 CPIJ019303 CPIJ005251 BGIBMGA004879 ACYPI006971 GB12547 AGAP011966 AAEL006331 PHUM561080 GLEAN_00110
Stocks & Reagents
Stocks Listed in FlyBase ( 13 )
Bloomington	34980 y1 sc* v1; P{TRiP.HMS01389}attP2 926 mwh1 ldsHor-D e1/T(1;3)OR60/TM3, Sb1 Ser1 16062 y1 w1118; PBac{5HPw+}ldsA190/TM3, Sb1 Ser1 3317 Dp(1;Y)BS; ru1 st1 lds1 e1 ca1/TM3, Sb1 30388 w*; Dp(1;3)DC271, PBac{DC271}VK00033/mwh1 ldsHor-D e1/TM3, Sb1 Ser1 30753 w*; Dp(1;3)DC312, PBac{DC312}VK00033/mwh1 ldsHor-D e1/TM3, Sb1 Ser1
Harvard	- PBac{RB}ldse00889
Kyoto	125446 w1118; P{RS5}lds5-HA-1872 106128 mwh1 ldsHor-D e1 / T(1;3)OR60 / TM3, Sb1 Ser1 106974 Dp(1;Y)BS; ru1 st1 lds1 e1 ca1/TM3, Sb1
VDRC	v13308 w1118 P{GD4508}v13308 v43950 w1118; P{GD4508}v43950
	More stocks available...
Genomic Clones ( 1 )
	BACR11D12 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 16 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	RE70645 RE74565
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	LD15750 LD15752 SD04967
Other clones	Dmel_neb_011655_0908_2096 EC03325 EC30646 EK091648 EK181627 EK223453 EK269105 EK306806 EP04551 FGM237A11 UUGC0485
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0002542 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 45305 45894
Antibody Information
	polyclonal (Girdham and Glover, 1991)
Other Information
Discoverer
Etymology
	Mutation is named "Horka" after a Hungarian clan that vanished by the beginning of the 14th century but their names survived in the names of settlements. (Erdelyi and Szabad, 1989)
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: lds CG2684 (Gong, 1999.11) Source for identity of: lds CG10445 (Gong, 1999.11)
Source for database merge of	Source for merge of: lds CG2684 (Bayraktaroglu, 2000.4.17) Source for merge of: lds Fs(3)Hor (Szalontai et al., 2005) Source for merge of: lds NTef2 (Liu et al., 1998)
Additional comments	scaRNA:mgU2-41 is encoded in an intron of lds. (Graveley et al., 2011) 'Note added in proof' in FBrf0080432 was in error; mus309, l(3)87Ae and lds are not, in fact, allelic.
Other Comments
	Only double stranded DNA (dsDNA) effectively activates the lds ATPase. Single stranded DNA (ssDNA) not only fails to activate the ATPase, but suppresses the dsDNA-dependent ATPase. Interaction of lds with dsDNA is important to couple the ATPase with the transcript release activity. Although properties of the product suggest that it might have helicase activity DNA unwinding activity associated with lds is undetectable. (Xie and Price, 1998) Transcript release activity of lds requires ATP or dATP and NTPs do not support the activity. (Xie and Price, 1997) A 154kD lds protein has been purified. This factor causes the release of transcripts by RNA polymerase II in an ATP-dependent manner. (Xie and Price, 1996) lds is essential for the production of DRB (5,6-dichloro-1-β-D-ribofuranosylbenzimidazole)-sensitive long transcripts in vitro, and consists of two subunits of 124 and 43kD. (Marshall and Price, 1995) Mutations in lds cause chromatin bridges at anaphase. (Girdham and Glover, 1991) Immunocytological approach is used to address the behaviour of essential mitotic gene products in embryonic cell cycles. (Glover et al., 1991) lds protein from Kc cell nuclear extracts suppresses the appearance of incomplete transcripts. (Price et al., 1987)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_080111 RefSeq (Proteins) • NP_524850 DDBJ / EMBL / GenBank • AAF54167 AAM48446 AAV36858 AY118417 BI487133 BT015973 CAA44496 CZ478726 X62629 Entrez Gene - A searchable database of RefSeq genes. • 45894 UniProtKB/Swiss-Prot • P34739 UniProtKB/TrEMBL • Q8MT27
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • SNF2-related (IPR000330) Helicase, C-terminal (IPR001650) DEAD-like helicase (IPR014001)
Linkouts
	BioGRID - A database of protein and genetic interactions • 69962 DroID - A comprehensive database of gene and protein interactions. • FBgn0002542 DRSC - Results from RNAi screens. • FBgn0002542 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0002542 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG2684-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0002542 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 45305 45894 InParanoid A subset of ortholog calls from InParanoid. • AAEL006331-PA Aedes aegypti (mosquito) AGAP011966-PA Anopheles gambiae (mosquito) XP_393754.2 Apis mellifera (honey bee) XP_001948361.1 Acyrthosiphon pisum (pea aphid) At1g11100.1 Arabidopsis thaliana (wall cress) XP_001897732.1 Brugia malayi (roundworm nematode) BGIBMGA004879-PA Bombyx mori (silk worm) ENSBTAP00000033620 Bos taurus (bovine) CAL0000717 Candida albicans (a form of yeast) CN12449 Caenorhabditis brenneri (small nematode) CBP30169 Caenorhabditis briggsae (nematode) CE41936 Caenorhabditis elegans (worm) ENSCAFP00000014474 Canis familiaris (dog) CAGL0G09493g Candida glabrata (haploid yeast) ENSCINP00000025373 Ciona intestinalis (sea squirt) JA10430 Caenorhabditis japonica (nematode) CMR259C Cyanidioschyzon merolae (red alga) cn02471 Cryptococcus neoformans (yeast-like fungus) ENSCPOP00000000533 Cavia porcellus (guinea pig) RP26662 Caenorhabditis remanei (nematode) ENSCSAVP00000004793 Ciona savignyi (sedentary tunicate) 34418 Capitella spl (polychaete worm) DDB0233429 Dictyostelium discoideum (amoeba) DEHA2G18722g Debaryomyces Hansenii (yeast) 260126 Daphnia pulex (daphnia) ENSDARP00000032185 Danio rerio (zebra fish) ENSECAP00000010511 Equus caballus (horse) ENSGACP00000001756 Gymnopilus aculeatus (mushroom) ENSGALP00000036135 Gallus gallus (chicken) 95427 Hypsipyla robusta (cedar shoot borer) ENSP00000358478 Homo sapiens (human) ISCW002351-PA Ixodes scapularis (deer tick) KLLA0F17479g Kluyveromyces lactis (yeast) 232224 Lottia gigantea (owl limpet) LmjF25.0740 Leishmania major (virus) 24613 Monocosta brevicollis (choanoflagellate) ENSMODP00000028991 Monodelphis domestica (gray opossum) ENSMMUP00000022223 Macaca mulatta (rhesus monkey) ENSMUSP00000049465 Mus musculus (house mouse) 10347 Nematostella vectensis (starlet anemone) XP_001603076.1 Nasonia vitripennis (wasp) ENSOANP00000000967 Ornithorynchus anatinus (platypus) ENSORLP00000016100 Oryzias latipes (japanese killifish) LOC_Os01g57110.1 Oryza sativa (asian rice) MAL13P1.216 Plasmodium falciparum (protozoal parasite) PHUM004122-PA Pediculus humanus (human body louse) PP28884 Pristionchus pacificus (nematode) 105578 Physcomitrella patens (moss) ENSPPYP00000001139 Pongo pygmaeus (orangutan) 79594 Phytophthora ramorum (sudden oak death pathogen) 124722 Phytophthora sojae (root rot pathogen) 764977 Populus trichocarpa (black cottonwood) ENSPTRP00000001988 Pan troglodytes (chimpanzee) PVX_083065 Plasmodium vivax (protozoal parasite) ENSRNOP00000052989 Rattus norvegicus (norway rat) 5053814 Sorghum bicolor (sorghum) YOR191W Saccharomyces cerevisiae (budding yeast) SPBC23E6.02 Schizosaccharomyces pombe (fission yeast) SPBC582.10c Schizosaccharomyces pombe (fission yeast) XP_787293.2 Strongylocentrotus purpuratus (purple sea urchin) XP_969437.2 Tribolium castaneum (red flour beetle) Tc00.1047053506925.140 Trypanosoma cruzi (parasitic trypanosome) ENSTNIP00000018754 Tetraodon nigroviridis (green spotted pufferfish) 268889 Thalassiosira pseudonana (marine diatom) ENSTRUP00000039857 Takifugu rubripes (pufferfish Takifugu) 3825.m02825 Tetrahymena thermophila (ciliate protozoa) YALI0E04136g Yarrowia lipolytica (nonconventional yeast) InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 45894 modMine - Data generated by the modENCODE project. • FBgn0002542 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB11893 NV16517 NV14737 LH22019 LH25090 ISCW002351 FBgn0242049 FBgn0214962 FBgn0197425 FBgn0191442 FBgn0165932 FBgn0165931 JGI_V11_274784 JGI_V11_54578 JGI_V11_6632 JGI_V11_249322 JGI_V11_35494 JGI_V11_308061 FBgn0075446 FBgn0161557 FBgn0145262 FBgn0125102 FBgn0106557 FBgn0095471 CPIJ019303 CPIJ005251 BGIBMGA004879 ACYPI006971 GB12547 AGAP011966 AAEL006331 PHUM561080 GLEAN_00110
Synonyms & Secondary IDs ( 19 )
Reported As
Symbol Synonym	CG2684 (Ni et al., 2011.7.19) DmF2 (Liu et al., 1998) early   Fs(3)Hor (Szabad et al., 1995, ) Fs(3)Horka (Erdelyi and Szabad, 1989) Fs(3)Sz11   Horka (Zallen and Wieschaus, 2004, Fitch et al., 1998, Szalontai et al., 2009) lds (Szalontai et al., 2009, Schneiderman et al., 2009, Cooper et al., 2010, Graveley et al., 2011) Lds (Anholt and Williams, 2010) lod (Foe et al., 1993) NTef2
Name Synonym	early-3   early-5   early-B   factor 2 (Peng et al., 1998, Xie and Price, 1996, Liu et al., 1998, Xie and Price, 1998, Xie and Price, 1997, Xie and Price, 1996, Marshall and Price, 1995, Price et al., 1987) Female sterile (3) Horka   lodestar (Stark et al., 2007, Szalontai et al., 2009) Negative transcription elongation factor 2 (Xie and Price, 1996, ) transcript A (Girdham and Glover, 1991)
Secondary FlyBase IDs
	FBgn0001050 FBgn0019956 FBgn0037532
References ( 55 )
Generate a list of	All references relating to this gene ( 55 )
List References by type	Research paper  ( 20 ) Supplementary material  ( 5 ) Review  ( 6 ) Personal communication to FlyBase  ( 7 ) Abstract  ( 4 ) FlyBase analysis  ( 2 ) Curated genome annotation  ( 2 ) Stock list  ( 1 ) Protein sequence record  ( 1 ) Computer file  ( 4 ) Automatic genome annotation  ( 1 ) Book  ( 1 )
Recent research papers ( 2 )
	Anholt and Williams, 2010, Chem. Senses 35(1): 21--30 The soluble proteome of the Drosophila antenna. [FBrf0209552] Cooper et al., 2010, Genetics 185(3): 811--822 Molecular Genetic Analysis of Chd3 and Polytene Chromosome Region 76B-D in Drosophila melanogaster. [FBrf0211329] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2010 Show reviews ...