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Gene Dmel\lin

General Information
Symbol	Dmel\lin	Species	D. melanogaster
Name	lines	Annotation symbol	CG11770
Feature type	protein_coding_gene	FlyBase ID	FBgn0002552
Gene Model Status	Current	Stock availability	6 publicly available
Genomic Location
Chromosome (arm)	2R	Recombination map	2-59
Cytogenetic map	44F6-44F7	Sequence location	2R:4,802,029..4,805,739 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene lines is referred to in FlyBase by the symbol Dmel\lin (CG11770, FBgn0002552). It is a protein_coding_gene from Drosophila melanogaster. Its molecular function is unknown. There is experimental evidence for 12 unique biological process terms, many of which group under: single-organism developmental process; digestive tract development; system development; digestive system development; biological regulation; axis specification; digestive tract morphogenesis; multicellular organismal development; open tracheal system development; anterior/posterior axis specification. 27 alleles are reported. The phenotypes of these alleles are annotated with: organ system; organ system subdivision; adult segment; acellular anatomical structure; non-connected developing system; embryonic hindgut; embryonic foregut; appendage segment; portion of tissue; keyhole structure; larval head segment; heart primordium; ectoderm derivative; spiracle. It has one annotated transcript and one annotated polypeptide. Protein features are: Protein Lines. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed within 00-06 hour embryonic stages. Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: larval central nervous system, larval/adult salivary gland, adult ovary. Comments on Affy2 ProbeSet: ProbeSet 1623324_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of lin. Gene sequence location is 2R:4802029..4805739.
User Contributed Data
	Beta version, feedback welcome
External Summaries
Phenotypic Description from the Red Book (Lindsley & Zimm 1992)
Gene/Allele symbols may differ from current usage	lin: lines (C. Nusslein-Volhard) Embryonic lethal; small anterior portion of each segment deleted; A8, spiracles, and anal plates absent. Head abnormal.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 44F6-44F7   Limits computationally determined from genome sequence between P{lacW}Dmnk16109&P{lacW}Gγ1k08017 and P{lacW}babok16912
Experimentally Determined Cytological Location
Cytogenetic map Notes References 44F-44F     (Hatini, 2000.5.25)
Experimentally Determined Recombination Data
Location	2-59 (Tearle and Nusslein-Volhard, 1987, )
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\lin for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Low-frequency RNA-Seq exon junction(s) not annotated. Gene model reviewed during 5.49
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) lin-RA FBtr0088651  NM_080076   3654   858
Additional Transcript Data & Comments
Reported size (kB)	3.416 (longest cDNA) (Hatini et al., 2000)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein lin-PA   FBpp0087732   96.3   858   4.96     NP_524815   AAF59024
Additional Polypeptide Data & Comments
Reported size (kDa)	858 (aa) (Hatini et al., 2000)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Protein Lines (IPR024875)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AE013599 AAF59024   AF272358 AAF76228   AI238228   AI512046   AI516489   AW943673   BI212590   BI357006   BI361923   BI362113   BI606537   BI621811   BI622466   BT021378 AAX33526   CK660102   CO266391   CO276597   CO276660   CO277649   CO278370   CO279160   CO284255   CO342959   DQ138794 ABA86400   EC061129   EC071673   EC071688   EC080998   EC199060   EC210102   EC244469   EC255723   EC260545   ES688856   ES693637   ES694153   ES694161   GH744925   GH765925   GH768731
UniProtKB/Swiss-Prot	Q9V4Z9
UniProtKB/TrEMBL	Q2XY68
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
immunolocalization Stage Tissue/Position (including subcellular localization) Reference embryonic stage 10   embryonic hindgut   (Iwaki et al., 2001) embryonic/larval midgut primordium | posterior   (Iwaki et al., 2001) organism | ubiquitous   (Iwaki et al., 2001) in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage   embryonic epidermis   (Hatini et al., 2000) mesoderm   (Hatini et al., 2000) stomodeum   (Hatini et al., 2000) inclusive hindgut primordium   (Hatini et al., 2000)
Additional Descriptive Data
	lin transcript is expressed widely, at low levels in the embryonic epidermis at the time of epidermal patterning and at higher levels in the hindgut and foregut primordia and in the mesoderm. (Hatini et al., 2000)
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
	lin protein localization could not be determined with the anti-lin antibody, or with Myc-tagged lin, so localization was studied by overexpressing lin using the GAL4-UAS system. In 10 hr. embryos carrying "UAS-Lin" (linScer\UAS.cHa) and the "Ptc-GAL4" driver (Scer\GAL4ptc-559.1), lin protein localizes to the nucleus in cells anterior to the en domain, but localizes to the cytoplasm posterior to the en domain. (Hatini et al., 2000)
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
cytoplasm inferred from direct assay (Hatini et al., 2000) nucleus inferred from direct assay (Hatini et al., 2000)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: larval central nervous system, larval/adult salivary gland, adult ovary. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    117.5 Larval Midgut    47.1 Larval Hindgut    71.2 Larval Malpighian Tubules    54.9 Larval Fat Body    54.9 Larval Salivary Gland    147.9 Larval Trachea    59.675 Larval Carcass    85.625 Adult Head    49.1 Adult Eye    44.575 Adult Brain    47.5 Adult Thoracic-Abdominal Ganglion    46.3 Adult Crop    74.4 Adult Midgut    58.6 Adult Hindgut    77.1 Adult Malpighian Tubules    55 Adult Fat Body    54.8 Adult Salivary Gland    128.3 Adult Heart    42.65 Adult VirginFemale Spermatheca    46.3 Adult InseminatedFemale Spermatheca    49.1 Adult Ovary    314 Adult Testis    43.3 Adult Male Accessory Gland    86.4 Adult Carcass    54.5 Expression Level Scale  None   Low   Moderate  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    117.5 Larval Midgut    47.1 Larval Hindgut    71.2 Larval Malpighian Tubules    54.9 Larval Fat Body    54.9 Larval Salivary Gland    147.9 Larval Trachea    59.675 Larval Carcass    85.625 Adult Head    49.1 Adult Eye    44.575 Adult Brain    47.5 Adult Thoracic-Abdominal Ganglion    46.3 Adult Crop    74.4 Adult Midgut    58.6 Adult Hindgut    77.1 Adult Malpighian Tubules    55 Adult Fat Body    54.8 Adult Salivary Gland    128.3 Adult Heart    42.65 Adult VirginFemale Spermatheca    46.3 Adult InseminatedFemale Spermatheca    49.1 Adult Ovary    314 Adult Testis    43.3 Adult Male Accessory Gland    86.4 Adult Carcass    54.5 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    117.5 Larval Midgut    47.1 Larval Hindgut    71.2 Larval Malpighian Tubules    54.9 Larval Fat Body    54.9 Larval Salivary Gland    147.9 Larval Trachea    59.675 Larval Carcass    85.625 Adult Head    49.1 Adult Eye    44.575 Adult Brain    47.5 Adult Thoracic-Abdominal Ganglion    46.3 Adult Crop    74.4 Adult Midgut    58.6 Adult Hindgut    77.1 Adult Malpighian Tubules    55 Adult Fat Body    54.8 Adult Salivary Gland    128.3 Adult Heart    42.65 Adult VirginFemale Spermatheca    46.3 Adult InseminatedFemale Spermatheca    49.1 Adult Ovary    314 Adult Testis    43.3 Adult Male Accessory Gland    86.4 Adult Carcass    54.5 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    117.5 Larval Midgut    47.1 Larval Hindgut    71.2 Larval Malpighian Tubules    54.9 Larval Fat Body    54.9 Larval Salivary Gland    147.9 Larval Trachea    59.675 Larval Carcass    85.625 Adult Head    49.1 Adult Eye    44.575 Adult Brain    47.5 Adult Thoracic-Abdominal Ganglion    46.3 Adult Crop    74.4 Adult Midgut    58.6 Adult Hindgut    77.1 Adult Malpighian Tubules    55 Adult Fat Body    54.8 Adult Salivary Gland    128.3 Adult Heart    42.65 Adult VirginFemale Spermatheca    46.3 Adult InseminatedFemale Spermatheca    49.1 Adult Ovary    314 Adult Testis    43.3 Adult Male Accessory Gland    86.4 Adult Carcass    54.5 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    117.5 Larval Midgut    47.1 Larval Hindgut    71.2 Larval Malpighian Tubules    54.9 Larval Fat Body    54.9 Larval Salivary Gland    147.9 Larval Trachea    59.675 Larval Carcass    85.625 Adult Head    49.1 Adult Eye    44.575 Adult Brain    47.5 Adult Thoracic-Abdominal Ganglion    46.3 Adult Crop    74.4 Adult Midgut    58.6 Adult Hindgut    77.1 Adult Malpighian Tubules    55 Adult Fat Body    54.8 Adult Salivary Gland    128.3 Adult Heart    42.65 Adult VirginFemale Spermatheca    46.3 Adult InseminatedFemale Spermatheca    49.1 Adult Ovary    314 Adult Testis    43.3 Adult Male Accessory Gland    86.4 Adult Carcass    54.5 Expression Level Scale  None   Low   Moderate   High  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    117.5 Larval Midgut    47.1 Larval Hindgut    71.2 Larval Malpighian Tubules    54.9 Larval Fat Body    54.9 Larval Salivary Gland    147.9 Larval Trachea    59.675 Larval Carcass    85.625 Adult Head    49.1 Adult Eye    44.575 Adult Brain    47.5 Adult Thoracic-Abdominal Ganglion    46.3 Adult Crop    74.4 Adult Midgut    58.6 Adult Hindgut    77.1 Adult Malpighian Tubules    55 Adult Fat Body    54.8 Adult Salivary Gland    128.3 Adult Heart    42.65 Adult VirginFemale Spermatheca    46.3 Adult InseminatedFemale Spermatheca    49.1 Adult Ovary    314 Adult Testis    43.3 Adult Male Accessory Gland    86.4 Adult Carcass    54.5 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    117.5 Larval Midgut    47.1 Larval Hindgut    71.2 Larval Malpighian Tubules    54.9 Larval Fat Body    54.9 Larval Salivary Gland    147.9 Larval Trachea    59.675 Larval Carcass    85.625 Adult Head    49.1 Adult Eye    44.575 Adult Brain    47.5 Adult Thoracic-Abdominal Ganglion    46.3 Adult Crop    74.4 Adult Midgut    58.6 Adult Hindgut    77.1 Adult Malpighian Tubules    55 Adult Fat Body    54.8 Adult Salivary Gland    128.3 Adult Heart    42.65 Adult VirginFemale Spermatheca    46.3 Adult InseminatedFemale Spermatheca    49.1 Adult Ovary    314 Adult Testis    43.3 Adult Male Accessory Gland    86.4 Adult Carcass    54.5 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    117.5 Larval Midgut    47.1 Larval Hindgut    71.2 Larval Malpighian Tubules    54.9 Larval Fat Body    54.9 Larval Salivary Gland    147.9 Larval Trachea    59.675 Larval Carcass    85.625 Adult Head    49.1 Adult Eye    44.575 Adult Brain    47.5 Adult Thoracic-Abdominal Ganglion    46.3 Adult Crop    74.4 Adult Midgut    58.6 Adult Hindgut    77.1 Adult Malpighian Tubules    55 Adult Fat Body    54.8 Adult Salivary Gland    128.3 Adult Heart    42.65 Adult VirginFemale Spermatheca    46.3 Adult InseminatedFemale Spermatheca    49.1 Adult Ovary    314 Adult Testis    43.3 Adult Male Accessory Gland    86.4 Adult Carcass    54.5 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    49.1   NA  Eye    44.575   NA  Brain    47.5   117.5  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    46.3   NA  Crop    74.4   47.1  Midgut    58.6   71.2  Hindgut    77.1   54.9  Malpighian Tubules    55   54.9  Fat Body    54.8   147.9  Salivary Gland    128.3   NA  Heart    42.65   59.675  Trachea    NA   NA  VirginFemale Spermatheca    46.3   NA  InseminatedFemale Spermatheca    49.1   NA  Ovary    314   NA  Testis    43.3   NA  Male Accessory Gland    86.4   85.625  Carcass    54.5 FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    36 central nervous system, larvae L3    25 central nervous system, pupae P8    9 head, virgin 1-day female    7 head, virgin 4-day female    9 head, virgin 20-day female    7 head, mated 1-day female    8 head, mated 4-day female    8 head, mated 20-day female    7 head, mated 1-day male    10 head, mated 4-day male    11 head, mated 20-day male    15 salivary gland, larvae L3 wandering    2 salivary gland, white prepupae    7 digestive system, larvae L3 wandering    7 digestive system, 1-day adult    8 digestive system, 4-day adult    12 digestive system, 20-day adult    14 fat body, larvae L3 wandering    8 fat body, white prepupae    10 fat body, pupae P8    7 carcass, larvae L3 wandering    22 carcass, 1-day adult    8 carcass, 4-day adult    12 carcass, 20-day adult    9 ovary, virgin 4-day female    67 ovary, mated 4-day female    103 testis, mated 4-day male    12 accessory gland, mated 4-day male    9 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (36) central nervous system, larvae L3    25 central nervous system, pupae P8    9 head, virgin 1-day female    7 head, virgin 4-day female    9 head, virgin 20-day female    7 head, mated 1-day female    8 head, mated 4-day female    8 head, mated 20-day female    7 head, mated 1-day male    10 head, mated 4-day male    11 head, mated 20-day male    15 salivary gland, larvae L3 wandering    2 salivary gland, white prepupae    7 digestive system, larvae L3 wandering    7 digestive system, 1-day adult    8 digestive system, 4-day adult    12 digestive system, 20-day adult    14 fat body, larvae L3 wandering    8 fat body, white prepupae    10 fat body, pupae P8    7 carcass, larvae L3 wandering    22 carcass, 1-day adult    8 carcass, 4-day adult    12 carcass, 20-day adult    9 ovary, virgin 4-day female  (67) ovary, mated 4-day female  (103) testis, mated 4-day male    12 accessory gland, mated 4-day male    9 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    36 central nervous system, larvae L3    25 central nervous system, pupae P8    9 head, virgin 1-day female    7 head, virgin 4-day female    9 head, virgin 20-day female    7 head, mated 1-day female    8 head, mated 4-day female    8 head, mated 20-day female    7 head, mated 1-day male    10 head, mated 4-day male    11 head, mated 20-day male    15 salivary gland, larvae L3 wandering    2 salivary gland, white prepupae    7 digestive system, larvae L3 wandering    7 digestive system, 1-day adult    8 digestive system, 4-day adult    12 digestive system, 20-day adult    14 fat body, larvae L3 wandering    8 fat body, white prepupae    10 fat body, pupae P8    7 carcass, larvae L3 wandering    22 carcass, 1-day adult    8 carcass, 4-day adult    12 carcass, 20-day adult    9 ovary, virgin 4-day female    67 ovary, mated 4-day female  103 testis, mated 4-day male    12 accessory gland, mated 4-day male    9 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    36 central nervous system, larvae L3    25 central nervous system, pupae P8    9 head, virgin 1-day female    7 head, virgin 4-day female    9 head, virgin 20-day female    7 head, mated 1-day female    8 head, mated 4-day female    8 head, mated 20-day female    7 head, mated 1-day male    10 head, mated 4-day male    11 head, mated 20-day male    15 salivary gland, larvae L3 wandering    2 salivary gland, white prepupae    7 digestive system, larvae L3 wandering    7 digestive system, 1-day adult    8 digestive system, 4-day adult    12 digestive system, 20-day adult    14 fat body, larvae L3 wandering    8 fat body, white prepupae    10 fat body, pupae P8    7 carcass, larvae L3 wandering    22 carcass, 1-day adult    8 carcass, 4-day adult    12 carcass, 20-day adult    9 ovary, virgin 4-day female    67 ovary, mated 4-day female    103 testis, mated 4-day male    12 accessory gland, mated 4-day male    9 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    36 central nervous system, larvae L3    25 central nervous system, pupae P8    9 head, virgin 1-day female    7 head, virgin 4-day female    9 head, virgin 20-day female    7 head, mated 1-day female    8 head, mated 4-day female    8 head, mated 20-day female    7 head, mated 1-day male    10 head, mated 4-day male    11 head, mated 20-day male    15 salivary gland, larvae L3 wandering    2 salivary gland, white prepupae    7 digestive system, larvae L3 wandering    7 digestive system, 1-day adult    8 digestive system, 4-day adult    12 digestive system, 20-day adult    14 fat body, larvae L3 wandering    8 fat body, white prepupae    10 fat body, pupae P8    7 carcass, larvae L3 wandering    22 carcass, 1-day adult    8 carcass, 4-day adult    12 carcass, 20-day adult    9 ovary, virgin 4-day female    67 ovary, mated 4-day female    103 testis, mated 4-day male    12 accessory gland, mated 4-day male    9 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (36) central nervous system, larvae L3    25 central nervous system, pupae P8    9 head, virgin 1-day female    7 head, virgin 4-day female    9 head, virgin 20-day female    7 head, mated 1-day female    8 head, mated 4-day female    8 head, mated 20-day female    7 head, mated 1-day male    10 head, mated 4-day male    11 head, mated 20-day male    15 salivary gland, larvae L3 wandering    2 salivary gland, white prepupae    7 digestive system, larvae L3 wandering    7 digestive system, 1-day adult    8 digestive system, 4-day adult    12 digestive system, 20-day adult    14 fat body, larvae L3 wandering    8 fat body, white prepupae    10 fat body, pupae P8    7 carcass, larvae L3 wandering    22 carcass, 1-day adult    8 carcass, 4-day adult    12 carcass, 20-day adult    9 ovary, virgin 4-day female  (67) ovary, mated 4-day female  (103) testis, mated 4-day male    12 accessory gland, mated 4-day male    9 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    36 central nervous system, larvae L3    25 central nervous system, pupae P8    9 head, virgin 1-day female    7 head, virgin 4-day female    9 head, virgin 20-day female    7 head, mated 1-day female    8 head, mated 4-day female    8 head, mated 20-day female    7 head, mated 1-day male    10 head, mated 4-day male    11 head, mated 20-day male    15 salivary gland, larvae L3 wandering    2 salivary gland, white prepupae    7 digestive system, larvae L3 wandering    7 digestive system, 1-day adult    8 digestive system, 4-day adult    12 digestive system, 20-day adult    14 fat body, larvae L3 wandering    8 fat body, white prepupae    10 fat body, pupae P8    7 carcass, larvae L3 wandering    22 carcass, 1-day adult    8 carcass, 4-day adult    12 carcass, 20-day adult    9 ovary, virgin 4-day female    67 ovary, mated 4-day female  103 testis, mated 4-day male    12 accessory gland, mated 4-day male    9 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    36 central nervous system, larvae L3    25 central nervous system, pupae P8    9 head, virgin 1-day female    7 head, virgin 4-day female    9 head, virgin 20-day female    7 head, mated 1-day female    8 head, mated 4-day female    8 head, mated 20-day female    7 head, mated 1-day male    10 head, mated 4-day male    11 head, mated 20-day male    15 salivary gland, larvae L3 wandering    2 salivary gland, white prepupae    7 digestive system, larvae L3 wandering    7 digestive system, 1-day adult    8 digestive system, 4-day adult    12 digestive system, 20-day adult    14 fat body, larvae L3 wandering    8 fat body, white prepupae    10 fat body, pupae P8    7 carcass, larvae L3 wandering    22 carcass, 1-day adult    8 carcass, 4-day adult    12 carcass, 20-day adult    9 ovary, virgin 4-day female    67 ovary, mated 4-day female    103 testis, mated 4-day male    12 accessory gland, mated 4-day male    9 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed within 00-06 hour embryonic stages. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    94 embryo 02-04hr    43 embryo 04-06hr    45 embryo 06-08hr    44 embryo 08-10hr    35 embryo 10-12hr    30 embryo 12-14hr    19 embryo 14-16hr    24 embryo 16-18hr    16 embryo 18-20hr    15 embryo 20-22hr    10 embryo 22-24hr    9 larva L1    12 larva L2    9 larva L3 12hr old    7 larva L3 puffstage 1-2    7 larva L3 puffstage 3-6    12 larva L3 puffstage 7-9    12 white prepupae new    14 white prepupae 12hr    15 white prepupae 24hr    19 pupae 2d postWPP    12 pupae 3d postWPP    6 pupae 4d postWPP    9 adult male 01day    9 adult male 05day    11 adult male 30day    13 adult female 01day    30 adult female 05day    40 adult female 30day    45 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (94) embryo 02-04hr  (43) embryo 04-06hr  (45) embryo 06-08hr  (44) embryo 08-10hr  (35) embryo 10-12hr  (30) embryo 12-14hr    19 embryo 14-16hr    24 embryo 16-18hr    16 embryo 18-20hr    15 embryo 20-22hr    10 embryo 22-24hr    9 larva L1    12 larva L2    9 larva L3 12hr old    7 larva L3 puffstage 1-2    7 larva L3 puffstage 3-6    12 larva L3 puffstage 7-9    12 white prepupae new    14 white prepupae 12hr    15 white prepupae 24hr    19 pupae 2d postWPP    12 pupae 3d postWPP    6 pupae 4d postWPP    9 adult male 01day    9 adult male 05day    11 adult male 30day    13 adult female 01day  (30) adult female 05day  (40) adult female 30day  (45) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    94 embryo 02-04hr    43 embryo 04-06hr    45 embryo 06-08hr    44 embryo 08-10hr    35 embryo 10-12hr    30 embryo 12-14hr    19 embryo 14-16hr    24 embryo 16-18hr    16 embryo 18-20hr    15 embryo 20-22hr    10 embryo 22-24hr    9 larva L1    12 larva L2    9 larva L3 12hr old    7 larva L3 puffstage 1-2    7 larva L3 puffstage 3-6    12 larva L3 puffstage 7-9    12 white prepupae new    14 white prepupae 12hr    15 white prepupae 24hr    19 pupae 2d postWPP    12 pupae 3d postWPP    6 pupae 4d postWPP    9 adult male 01day    9 adult male 05day    11 adult male 30day    13 adult female 01day    30 adult female 05day    40 adult female 30day    45 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    94 embryo 02-04hr    43 embryo 04-06hr    45 embryo 06-08hr    44 embryo 08-10hr    35 embryo 10-12hr    30 embryo 12-14hr    19 embryo 14-16hr    24 embryo 16-18hr    16 embryo 18-20hr    15 embryo 20-22hr    10 embryo 22-24hr    9 larva L1    12 larva L2    9 larva L3 12hr old    7 larva L3 puffstage 1-2    7 larva L3 puffstage 3-6    12 larva L3 puffstage 7-9    12 white prepupae new    14 white prepupae 12hr    15 white prepupae 24hr    19 pupae 2d postWPP    12 pupae 3d postWPP    6 pupae 4d postWPP    9 adult male 01day    9 adult male 05day    11 adult male 30day    13 adult female 01day    30 adult female 05day    40 adult female 30day    45 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    94 embryo 02-04hr    43 embryo 04-06hr    45 embryo 06-08hr    44 embryo 08-10hr    35 embryo 10-12hr    30 embryo 12-14hr    19 embryo 14-16hr    24 embryo 16-18hr    16 embryo 18-20hr    15 embryo 20-22hr    10 embryo 22-24hr    9 larva L1    12 larva L2    9 larva L3 12hr old    7 larva L3 puffstage 1-2    7 larva L3 puffstage 3-6    12 larva L3 puffstage 7-9    12 white prepupae new    14 white prepupae 12hr    15 white prepupae 24hr    19 pupae 2d postWPP    12 pupae 3d postWPP    6 pupae 4d postWPP    9 adult male 01day    9 adult male 05day    11 adult male 30day    13 adult female 01day    30 adult female 05day    40 adult female 30day    45 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (94) embryo 02-04hr  (43) embryo 04-06hr  (45) embryo 06-08hr  (44) embryo 08-10hr  (35) embryo 10-12hr  30 embryo 12-14hr    19 embryo 14-16hr    24 embryo 16-18hr    16 embryo 18-20hr    15 embryo 20-22hr    10 embryo 22-24hr    9 larva L1    12 larva L2    9 larva L3 12hr old    7 larva L3 puffstage 1-2    7 larva L3 puffstage 3-6    12 larva L3 puffstage 7-9    12 white prepupae new    14 white prepupae 12hr    15 white prepupae 24hr    19 pupae 2d postWPP    12 pupae 3d postWPP    6 pupae 4d postWPP    9 adult male 01day    9 adult male 05day    11 adult male 30day    13 adult female 01day  30 adult female 05day  (40) adult female 30day  (45) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    94 embryo 02-04hr    43 embryo 04-06hr    45 embryo 06-08hr    44 embryo 08-10hr    35 embryo 10-12hr    30 embryo 12-14hr    19 embryo 14-16hr    24 embryo 16-18hr    16 embryo 18-20hr    15 embryo 20-22hr    10 embryo 22-24hr    9 larva L1    12 larva L2    9 larva L3 12hr old    7 larva L3 puffstage 1-2    7 larva L3 puffstage 3-6    12 larva L3 puffstage 7-9    12 white prepupae new    14 white prepupae 12hr    15 white prepupae 24hr    19 pupae 2d postWPP    12 pupae 3d postWPP    6 pupae 4d postWPP    9 adult male 01day    9 adult male 05day    11 adult male 30day    13 adult female 01day    30 adult female 05day    40 adult female 30day    45 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    94 embryo 02-04hr    43 embryo 04-06hr    45 embryo 06-08hr    44 embryo 08-10hr    35 embryo 10-12hr    30 embryo 12-14hr    19 embryo 14-16hr    24 embryo 16-18hr    16 embryo 18-20hr    15 embryo 20-22hr    10 embryo 22-24hr    9 larva L1    12 larva L2    9 larva L3 12hr old    7 larva L3 puffstage 1-2    7 larva L3 puffstage 3-6    12 larva L3 puffstage 7-9    12 white prepupae new    14 white prepupae 12hr    15 white prepupae 24hr    19 pupae 2d postWPP    12 pupae 3d postWPP    6 pupae 4d postWPP    9 adult male 01day    9 adult male 05day    11 adult male 30day    13 adult female 01day    30 adult female 05day    40 adult female 30day    45 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    28 Schneider line 2 Sg4    18 embryonic 1182-4H    33 embryonic GM2    25 embryonic Kc167    21 embryonic S1    72 embryonic S3    25 leg disc CME L1    27 wing disc CME-W2    13 wing disc ML-DmD8    19 wing disc ML-DmD9    34 wing disc ML-DmD16-c3    41 wing disc ML-DmD21    21 wing disc ML-DmD32    42 haltere disc ML-DmD17-c3    27 eye-antennal disc ML-DmD11    28 antennal disc ML-DmD20-c5    18 mixed discs ML-DmD4-c1    29 CNS ML-DmBG1-c1    45 CNS ML-DmBG2-c2    30 tumorous blood cells mbn2    18 ovary fGS/OSS    39 ovary OSC    24 ovary OSS    8 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (28) Schneider line 2 Sg4    18 embryonic 1182-4H  (33) embryonic GM2    25 embryonic Kc167    21 embryonic S1  (72) embryonic S3    25 leg disc CME L1  (27) wing disc CME-W2    13 wing disc ML-DmD8    19 wing disc ML-DmD9  (34) wing disc ML-DmD16-c3  (41) wing disc ML-DmD21    21 wing disc ML-DmD32  (42) haltere disc ML-DmD17-c3  (27) eye-antennal disc ML-DmD11  (28) antennal disc ML-DmD20-c5    18 mixed discs ML-DmD4-c1  (29) CNS ML-DmBG1-c1  (45) CNS ML-DmBG2-c2  (30) tumorous blood cells mbn2    18 ovary fGS/OSS  (39) ovary OSC    24 ovary OSS    8 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    28 Schneider line 2 Sg4    18 embryonic 1182-4H    33 embryonic GM2    25 embryonic Kc167    21 embryonic S1    72 embryonic S3    25 leg disc CME L1    27 wing disc CME-W2    13 wing disc ML-DmD8    19 wing disc ML-DmD9    34 wing disc ML-DmD16-c3    41 wing disc ML-DmD21    21 wing disc ML-DmD32    42 haltere disc ML-DmD17-c3    27 eye-antennal disc ML-DmD11    28 antennal disc ML-DmD20-c5    18 mixed discs ML-DmD4-c1    29 CNS ML-DmBG1-c1    45 CNS ML-DmBG2-c2    30 tumorous blood cells mbn2    18 ovary fGS/OSS    39 ovary OSC    24 ovary OSS    8 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    28 Schneider line 2 Sg4    18 embryonic 1182-4H    33 embryonic GM2    25 embryonic Kc167    21 embryonic S1    72 embryonic S3    25 leg disc CME L1    27 wing disc CME-W2    13 wing disc ML-DmD8    19 wing disc ML-DmD9    34 wing disc ML-DmD16-c3    41 wing disc ML-DmD21    21 wing disc ML-DmD32    42 haltere disc ML-DmD17-c3    27 eye-antennal disc ML-DmD11    28 antennal disc ML-DmD20-c5    18 mixed discs ML-DmD4-c1    29 CNS ML-DmBG1-c1    45 CNS ML-DmBG2-c2    30 tumorous blood cells mbn2    18 ovary fGS/OSS    39 ovary OSC    24 ovary OSS    8 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    28 Schneider line 2 Sg4    18 embryonic 1182-4H    33 embryonic GM2    25 embryonic Kc167    21 embryonic S1    72 embryonic S3    25 leg disc CME L1    27 wing disc CME-W2    13 wing disc ML-DmD8    19 wing disc ML-DmD9    34 wing disc ML-DmD16-c3    41 wing disc ML-DmD21    21 wing disc ML-DmD32    42 haltere disc ML-DmD17-c3    27 eye-antennal disc ML-DmD11    28 antennal disc ML-DmD20-c5    18 mixed discs ML-DmD4-c1    29 CNS ML-DmBG1-c1    45 CNS ML-DmBG2-c2    30 tumorous blood cells mbn2    18 ovary fGS/OSS    39 ovary OSC    24 ovary OSS    8 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  28 Schneider line 2 Sg4    18 embryonic 1182-4H  (33) embryonic GM2    25 embryonic Kc167    21 embryonic S1  (72) embryonic S3    25 leg disc CME L1  27 wing disc CME-W2    13 wing disc ML-DmD8    19 wing disc ML-DmD9  (34) wing disc ML-DmD16-c3  (41) wing disc ML-DmD21    21 wing disc ML-DmD32  (42) haltere disc ML-DmD17-c3  27 eye-antennal disc ML-DmD11  28 antennal disc ML-DmD20-c5    18 mixed discs ML-DmD4-c1  29 CNS ML-DmBG1-c1  (45) CNS ML-DmBG2-c2  30 tumorous blood cells mbn2    18 ovary fGS/OSS  (39) ovary OSC    24 ovary OSS    8 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    28 Schneider line 2 Sg4    18 embryonic 1182-4H    33 embryonic GM2    25 embryonic Kc167    21 embryonic S1    72 embryonic S3    25 leg disc CME L1    27 wing disc CME-W2    13 wing disc ML-DmD8    19 wing disc ML-DmD9    34 wing disc ML-DmD16-c3    41 wing disc ML-DmD21    21 wing disc ML-DmD32    42 haltere disc ML-DmD17-c3    27 eye-antennal disc ML-DmD11    28 antennal disc ML-DmD20-c5    18 mixed discs ML-DmD4-c1    29 CNS ML-DmBG1-c1    45 CNS ML-DmBG2-c2    30 tumorous blood cells mbn2    18 ovary fGS/OSS    39 ovary OSC    24 ovary OSS    8 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    28 Schneider line 2 Sg4    18 embryonic 1182-4H    33 embryonic GM2    25 embryonic Kc167    21 embryonic S1    72 embryonic S3    25 leg disc CME L1    27 wing disc CME-W2    13 wing disc ML-DmD8    19 wing disc ML-DmD9    34 wing disc ML-DmD16-c3    41 wing disc ML-DmD21    21 wing disc ML-DmD32    42 haltere disc ML-DmD17-c3    27 eye-antennal disc ML-DmD11    28 antennal disc ML-DmD20-c5    18 mixed discs ML-DmD4-c1    29 CNS ML-DmBG1-c1    45 CNS ML-DmBG2-c2    30 tumorous blood cells mbn2    18 ovary fGS/OSS    39 ovary OSC    24 ovary OSS    8 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    40 cold shock, 4-day adult    21 heat shock, 4-day adult    26 Cadmium 50 mM 6 hrs, larvae L3    6 Cadmium 50 mM 12 hrs, larvae L3    4 Cadmium 50 mM 48 hrs, 4-day adult    36 Cadmium 100 mM 48 hrs, 4-day adult    84 Copper 0.5 mM 12 hrs, larvae L3    10 Copper 15 mM 48 hrs, 4-day adult    30 Zinc 5 mM 12 hrs, larvae L3    11 Zinc 4.5 mM 48 hrs, 4-day adult    16 Ethanol 2.5% 3 hrs, larvae L3    62 Ethanol 5% 3 hrs, larvae L3    5 Ethanol 10% 3 hrs, larvae L3    7 Caffeine 1.5 mg/ml 4 hrs, larvae L3    5 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    75 Caffeine 25 mg/ml 48 hrs, 4-day adult    42 Paraquat 5 mM 48 hrs, 4-day adult    56 Paraquat 10 mM 48 hrs, 4-day adult    41 Rotenone 2 μg 12 hrs, larvae L3    4 Rotenone 8 μg 12 hrs, larvae L3    6 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult  (40) cold shock, 4-day adult    21 heat shock, 4-day adult  26 Cadmium 50 mM 6 hrs, larvae L3    6 Cadmium 50 mM 12 hrs, larvae L3    4 Cadmium 50 mM 48 hrs, 4-day adult  (36) Cadmium 100 mM 48 hrs, 4-day adult  (84) Copper 0.5 mM 12 hrs, larvae L3    10 Copper 15 mM 48 hrs, 4-day adult  (30) Zinc 5 mM 12 hrs, larvae L3    11 Zinc 4.5 mM 48 hrs, 4-day adult    16 Ethanol 2.5% 3 hrs, larvae L3  (62) Ethanol 5% 3 hrs, larvae L3    5 Ethanol 10% 3 hrs, larvae L3    7 Caffeine 1.5 mg/ml 4 hrs, larvae L3    5 Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (75) Caffeine 25 mg/ml 48 hrs, 4-day adult  (42) Paraquat 5 mM 48 hrs, 4-day adult  (56) Paraquat 10 mM 48 hrs, 4-day adult  (41) Rotenone 2 μg 12 hrs, larvae L3    4 Rotenone 8 μg 12 hrs, larvae L3    6 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    40 cold shock, 4-day adult    21 heat shock, 4-day adult    26 Cadmium 50 mM 6 hrs, larvae L3    6 Cadmium 50 mM 12 hrs, larvae L3    4 Cadmium 50 mM 48 hrs, 4-day adult    36 Cadmium 100 mM 48 hrs, 4-day adult    84 Copper 0.5 mM 12 hrs, larvae L3    10 Copper 15 mM 48 hrs, 4-day adult    30 Zinc 5 mM 12 hrs, larvae L3    11 Zinc 4.5 mM 48 hrs, 4-day adult    16 Ethanol 2.5% 3 hrs, larvae L3    62 Ethanol 5% 3 hrs, larvae L3    5 Ethanol 10% 3 hrs, larvae L3    7 Caffeine 1.5 mg/ml 4 hrs, larvae L3    5 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    75 Caffeine 25 mg/ml 48 hrs, 4-day adult    42 Paraquat 5 mM 48 hrs, 4-day adult    56 Paraquat 10 mM 48 hrs, 4-day adult    41 Rotenone 2 μg 12 hrs, larvae L3    4 Rotenone 8 μg 12 hrs, larvae L3    6 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    40 cold shock, 4-day adult    21 heat shock, 4-day adult    26 Cadmium 50 mM 6 hrs, larvae L3    6 Cadmium 50 mM 12 hrs, larvae L3    4 Cadmium 50 mM 48 hrs, 4-day adult    36 Cadmium 100 mM 48 hrs, 4-day adult    84 Copper 0.5 mM 12 hrs, larvae L3    10 Copper 15 mM 48 hrs, 4-day adult    30 Zinc 5 mM 12 hrs, larvae L3    11 Zinc 4.5 mM 48 hrs, 4-day adult    16 Ethanol 2.5% 3 hrs, larvae L3    62 Ethanol 5% 3 hrs, larvae L3    5 Ethanol 10% 3 hrs, larvae L3    7 Caffeine 1.5 mg/ml 4 hrs, larvae L3    5 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    75 Caffeine 25 mg/ml 48 hrs, 4-day adult    42 Paraquat 5 mM 48 hrs, 4-day adult    56 Paraquat 10 mM 48 hrs, 4-day adult    41 Rotenone 2 μg 12 hrs, larvae L3    4 Rotenone 8 μg 12 hrs, larvae L3    6 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    40 cold shock, 4-day adult    21 heat shock, 4-day adult    26 Cadmium 50 mM 6 hrs, larvae L3    6 Cadmium 50 mM 12 hrs, larvae L3    4 Cadmium 50 mM 48 hrs, 4-day adult    36 Cadmium 100 mM 48 hrs, 4-day adult    84 Copper 0.5 mM 12 hrs, larvae L3    10 Copper 15 mM 48 hrs, 4-day adult    30 Zinc 5 mM 12 hrs, larvae L3    11 Zinc 4.5 mM 48 hrs, 4-day adult    16 Ethanol 2.5% 3 hrs, larvae L3    62 Ethanol 5% 3 hrs, larvae L3    5 Ethanol 10% 3 hrs, larvae L3    7 Caffeine 1.5 mg/ml 4 hrs, larvae L3    5 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    75 Caffeine 25 mg/ml 48 hrs, 4-day adult    42 Paraquat 5 mM 48 hrs, 4-day adult    56 Paraquat 10 mM 48 hrs, 4-day adult    41 Rotenone 2 μg 12 hrs, larvae L3    4 Rotenone 8 μg 12 hrs, larvae L3    6 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult  (40) cold shock, 4-day adult    21 heat shock, 4-day adult  26 Cadmium 50 mM 6 hrs, larvae L3    6 Cadmium 50 mM 12 hrs, larvae L3    4 Cadmium 50 mM 48 hrs, 4-day adult  (36) Cadmium 100 mM 48 hrs, 4-day adult  (84) Copper 0.5 mM 12 hrs, larvae L3    10 Copper 15 mM 48 hrs, 4-day adult  30 Zinc 5 mM 12 hrs, larvae L3    11 Zinc 4.5 mM 48 hrs, 4-day adult    16 Ethanol 2.5% 3 hrs, larvae L3  (62) Ethanol 5% 3 hrs, larvae L3    5 Ethanol 10% 3 hrs, larvae L3    7 Caffeine 1.5 mg/ml 4 hrs, larvae L3    5 Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (75) Caffeine 25 mg/ml 48 hrs, 4-day adult  (42) Paraquat 5 mM 48 hrs, 4-day adult  (56) Paraquat 10 mM 48 hrs, 4-day adult  (41) Rotenone 2 μg 12 hrs, larvae L3    4 Rotenone 8 μg 12 hrs, larvae L3    6 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    40 cold shock, 4-day adult    21 heat shock, 4-day adult    26 Cadmium 50 mM 6 hrs, larvae L3    6 Cadmium 50 mM 12 hrs, larvae L3    4 Cadmium 50 mM 48 hrs, 4-day adult    36 Cadmium 100 mM 48 hrs, 4-day adult    84 Copper 0.5 mM 12 hrs, larvae L3    10 Copper 15 mM 48 hrs, 4-day adult    30 Zinc 5 mM 12 hrs, larvae L3    11 Zinc 4.5 mM 48 hrs, 4-day adult    16 Ethanol 2.5% 3 hrs, larvae L3    62 Ethanol 5% 3 hrs, larvae L3    5 Ethanol 10% 3 hrs, larvae L3    7 Caffeine 1.5 mg/ml 4 hrs, larvae L3    5 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    75 Caffeine 25 mg/ml 48 hrs, 4-day adult    42 Paraquat 5 mM 48 hrs, 4-day adult    56 Paraquat 10 mM 48 hrs, 4-day adult    41 Rotenone 2 μg 12 hrs, larvae L3    4 Rotenone 8 μg 12 hrs, larvae L3    6 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    40 cold shock, 4-day adult    21 heat shock, 4-day adult    26 Cadmium 50 mM 6 hrs, larvae L3    6 Cadmium 50 mM 12 hrs, larvae L3    4 Cadmium 50 mM 48 hrs, 4-day adult    36 Cadmium 100 mM 48 hrs, 4-day adult    84 Copper 0.5 mM 12 hrs, larvae L3    10 Copper 15 mM 48 hrs, 4-day adult    30 Zinc 5 mM 12 hrs, larvae L3    11 Zinc 4.5 mM 48 hrs, 4-day adult    16 Ethanol 2.5% 3 hrs, larvae L3    62 Ethanol 5% 3 hrs, larvae L3    5 Ethanol 10% 3 hrs, larvae L3    7 Caffeine 1.5 mg/ml 4 hrs, larvae L3    5 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    75 Caffeine 25 mg/ml 48 hrs, 4-day adult    42 Paraquat 5 mM 48 hrs, 4-day adult    56 Paraquat 10 mM 48 hrs, 4-day adult    41 Rotenone 2 μg 12 hrs, larvae L3    4 Rotenone 8 μg 12 hrs, larvae L3    6 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010, Graveley et al., 2011) mE2_34_mRNA_expression_cluster_13 mE1_20_mRNA_expression_cluster_04
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0002552 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG11770-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal, with Scer\GAL4byn-Gal4 linScer\UAS.cHa lethal | embryonic stage | recessive linunspecified lethal | larval stage lin4 lin5 lin6 lethal | recessive lin7 lin8 lin9 lin10 partially lethal - majority die | pupal stage, with Scer\GAL4pnr-MD237 linGD1479 Other Phenotypes Allele increased cell death, with Scer\GAL4Ubx-lac1-Gal4 linScer\UAS.cHa visible, with Scer\GAL4klu-G410 linScer\UAS.cHa visible, with Scer\GAL4pnr-MD237 linGD1479 visible, with Scer\GAL4Ubx-lac1-Gal4 linScer\UAS.cHa visible | pharate adult stage, with Scer\GAL4dpp.blk1 linScer\UAS.cHa visible | somatic clone linG2 visible | somatic clone, with Scer\GAL4Act5C.PU linScer\UAS.cHa wild-type lin+t24.KpnICu lin+t24 Phenotype manifest in Allele abdominal segment 8 lin2 adult thorax, with Scer\GAL4Ubx-lac1-Gal4 linScer\UAS.cHa adult thorax | somatic clone, with Scer\GAL4Act5C.PU linScer\UAS.cHa anal pad linG1 anal plate linunspecified antenna | ectopic, with Scer\GAL4dpp.blk1 linScer\UAS.cHa antenna | somatic clone linG2 antennal disc, with Scer\GAL4dpp.blk1 linScer\UAS.cHa arista, with Scer\GAL4bab1-Agal4-5 linGD1479 arista, with Scer\GAL4bab1-Pgal4-2 linGD1479 arista, with Scer\GAL4dac-p7d23 linGD1479 basal cylinder, with Scer\GAL4bab1-Agal4-5 linGD1479 basal cylinder, with Scer\GAL4bab1-Pgal4-2 linGD1479 basal cylinder, with Scer\GAL4dac-p7d23 linGD1479 basal cylinder, with Scer\GAL4rn-GAL4-DeltaS linGD1479 denticle | ectopic (with lin2) linG2 denticle | ectopic (with linG2) lin2 denticle belt linG1 denticle belt (with lin2) linG2 denticle belt (with linG2) lin2 denticle belt & abdominal segment 8 linG1 denticle row 1 (with lin2) linG2 denticle row 1 (with linG2) lin2 denticle row 2 (with lin2) linG2 denticle row 2 (with linG2) lin2 denticle row 2 | ectopic, with Scer\GAL4ptc-559.1, lin2, linG2 linScer\UAS.cHa denticle row 2 | ectopic, with Scer\GAL4ptc-559.1, lin2, linScer\UAS.cHa linG2 denticle row 2 | ectopic, with Scer\GAL4ptc-559.1, linG2, linScer\UAS.cHa lin2 denticle row 2 | ectopic, with Scer\GAL4ptc-559.1, linG2/lin2 linScer\UAS.cHa denticle row 2 | ectopic (with lin2), with Scer\GAL4ptc-559.1, linScer\UAS.cHa linG2 denticle row 2 | ectopic (with linG2), with Scer\GAL4ptc-559.1, linScer\UAS.cHa lin2 denticle row 3 (with lin2) linG2 denticle row 3 (with linG2) lin2 denticle row 3 | ectopic, with Scer\GAL4ptc-559.1, lin2, linG2 linScer\UAS.cHa denticle row 3 | ectopic, with Scer\GAL4ptc-559.1, lin2, linScer\UAS.cHa linG2 denticle row 3 | ectopic, with Scer\GAL4ptc-559.1, linG2, linScer\UAS.cHa lin2 denticle row 3 | ectopic, with Scer\GAL4ptc-559.1, linG2/lin2 linScer\UAS.cHa denticle row 3 | ectopic (with lin2), with Scer\GAL4ptc-559.1, linScer\UAS.cHa linG2 denticle row 3 | ectopic (with linG2), with Scer\GAL4ptc-559.1, linScer\UAS.cHa lin2 denticle row 4 (with lin2) linG2 denticle row 4 (with linG2) lin2 disc epithelium proper & dorsal mesothoracic disc | somatic clone linunspecified dorsal denticle, with Scer\GAL4ptc-559.1 linScer\UAS.cHa dorsal denticle | ectopic (with lin2) linG2 dorsal denticle | ectopic (with linG2) lin2 dorsal fine hair lin2 dorsal fine hair | ectopic, with Scer\GAL4ptc-559.1 linScer\UAS.cHa dorsal thick hair lin2 dorsal thick hair, with Scer\GAL4ptc-559.1 linScer\UAS.cHa embryonic/larval hindgut | embryonic stage lin2 embryonic/larval posterior spiracle lin2 linG1 embryonic/larval somatic muscle | dorsal lin2 embryonic abdominal segment 8 linunspecified embryonic dorsal epidermis linunspecified embryonic dorsal epidermis, with Scer\GAL4ptc-559.1 linScer\UAS.cHa embryonic epidermis | dorsal linunspecified embryonic epidermis | dorsal, with Scer\GAL4ptc-559.1 linScer\UAS.cHa embryonic foregut linunspecified embryonic head linunspecified embryonic hindgut lin2 linunspecified embryonic hindgut, with Scer\GAL4byn-Gal4 linScer\UAS.cHa embryonic large intestine linunspecified embryonic Malpighian tubule lin2 embryonic proventriculus linunspecified embryonic segment | anterior linunspecified eye | somatic clone lin13B eye disc | somatic clone, with Scer\GAL4Act5C.PP linScer\UAS.cHa head capsule, with Scer\GAL4dpp.blk1 linScer\UAS.cHa heart primordium lindsRNA.cKa lindsRNA.si.cKa hindgut proper primordium linG1 keyhole structure linunspecified mesothoracic tergum, with Scer\GAL4pnr-MD237 linGD1479 mouthpart linG1 peripodial epithelium & dorsal mesothoracic disc, with Scer\GAL4ptc-559.1 linScer\UAS.cHa peripodial epithelium & dorsal mesothoracic disc, with Scer\GAL4Ubx-lac1-Gal4 linScer\UAS.cHa peripodial epithelium & dorsal mesothoracic disc | somatic clone, with Scer\GAL4Act5C.PU linScer\UAS.cHa photoreceptor cell | somatic clone lin13B prescutum, with Scer\GAL4klu-G410 linScer\UAS.cHa primordium of embryonic/larval spiracle linunspecified prothoracic tarsal segment, with Scer\GAL4bab1-Agal4-5 linGD1479 prothoracic tarsal segment, with Scer\GAL4bab1-Pgal4-2 linGD1479 prothoracic tarsal segment, with Scer\GAL4dac-p7d23 linGD1479 prothoracic tarsal segment, with Scer\GAL4Dll-md23 linGD1479 prothoracic tarsal segment, with Scer\GAL4rn-GAL4-DeltaS linGD1479 prothoracic tarsal segment | cell autonomous | somatic clone linG2 sex comb, with Scer\GAL4bab1-Agal4-5 linGD1479 sex comb, with Scer\GAL4bab1-Pgal4-2 linGD1479 sex comb, with Scer\GAL4dac-p7d23 linGD1479 sex comb, with Scer\GAL4Dll-md23 linGD1479 sex comb, with Scer\GAL4rn-GAL4-DeltaS linGD1479 third segment of antenna, with Scer\GAL4dac-p7d23 linGD1479 third segment of antenna, with Scer\GAL4rn-GAL4-DeltaS linGD1479 wing hinge primordium | somatic clone linunspecified
Classical Alleles ( 19 )
For All Classical Alleles Show
Allele of lin Class Mutagen Stocks Known lesion lin2 ethyl methanesulfonate 2 Yes linG2 1 -- lin10 ethyl methanesulfonate 0 -- lin13B ethyl methanesulfonate 0 -- lin1 ethyl methanesulfonate 0 -- lin2u 0 -- lin3 ethyl methanesulfonate 0 -- lin44Fj-2 ethyl methanesulfonate 0 -- lin45Bc-3 ethyl methanesulfonate 0 -- lin4 ethyl methanesulfonate 0 -- lin5 ethyl methanesulfonate 0 -- lin6 ethyl methanesulfonate 0 -- lin7 ethyl methanesulfonate 0 -- lin8 ethyl methanesulfonate 0 -- lin9 ethyl methanesulfonate 0 -- linG10 0 -- linG1 0 -- linP14A ethyl methanesulfonate 0 -- linunspecified 0 --
Alleles Carried on Transgenic Constructs ( 8 )
For All Alleles Carried on Transgenic Constructs Show
Allele of lin Class Mutagen Stocks Known lesion linGD1479 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes linHMS02187 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes linScer\UAS.cHa in vitro construct - regulatory fusion 1 Yes lin+t24.KpnICu in vitro construct - genomic fragment 0 Yes lin+t24 in vitro construct - genomic fragment 0 Yes lindsRNA.cKa in vitro construct - RNAi 0 Yes lindsRNA.si.cKa in vitro construct - RNAi 0 Yes linScer\UAS.T:Hsap\MYC in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(2R)eve-1.18 (Tearle and Nusslein-Volhard, 1987) Df(2R)eve-2.28 (Tearle and Nusslein-Volhard, 1987) Df(2R)Exel8048 (Ryder, 2004.4.26) Df(2R)G75 (Castelli-Gair, 1998, Hatini et al., 2000, Mohr and Boswell, 2002, Zheng et al., 2003) Df(2R)H3E1 (Mohr and Boswell, 2002, Zheng et al., 2003) Df(2R)Np1 (Zheng et al., 2003) Df(2R)Np3 (Mohr and Boswell, 2002) Df(2R)P15 (Hatini et al., 2000)
Not disrupted in	Df(2R)44CE (Mohr and Boswell, 2002) Df(2R)Np4 (Zheng et al., 2003) Df(2R)Np5 (Mohr and Boswell, 2002) Df(2R)w45-30n (Mohr and Boswell, 2002) Df(2R)w73-2 (Mohr and Boswell, 2002)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD1479} NA P{TRiP.HMS02187} NA P{UAS-lin.H} NA P{UAS-lin.Myc} NA characterization construct P{lin+t24.KpnICu} NA P{lin+t24} NA
Insertions
	Type of insertions Name Expression data
Gene Ontology: Function, Process & Cellular Component ( 14 unique terms )
Terms Based on Experimental Evidence ( 14 terms )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
embryonic foregut morphogenesis inferred from mutant phenotype (assigned by UniProtKB) (Johansen et al., 2003) embryonic hindgut morphogenesis inferred from mutant phenotype (assigned by UniProtKB) (Johansen et al., 2003) embryonic pattern specification inferred from mutant phenotype (assigned by UniProtKB) (Bokor and DiNardo, 1996) epidermis development inferred from mutant phenotype (Hatini et al., 2000) foregut morphogenesis inferred from mutant phenotype (Green et al., 2002) hindgut morphogenesis inferred from mutant phenotype (Iwaki et al., 2001, Green et al., 2002) positive regulation of transcription from RNA polymerase II promoter inferred from mutant phenotype (assigned by UniProtKB) (Castelli-Gair, 1998) proximal/distal axis specification inferred from mutant phenotype (Greenberg and Hatini, 2009) spiracle morphogenesis, open tracheal system inferred from mutant phenotype (assigned by UniProtKB) (Castelli-Gair, 1998) terminal region determination inferred from genetic interaction with tor (Strecker et al., 1991) torso signaling pathway inferred from genetic interaction with tor (Strecker et al., 1991) wing disc development inferred from mutant phenotype (Nusinow et al., 2008)
Cellular Component
CV term Evidence References
cytoplasm inferred from direct assay (Hatini et al., 2000) nucleus inferred from direct assay (Hatini et al., 2000)
Terms Based on Predictions or Assertions ( 0 terms )
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
protein-protein
Interacting group Assay References
lin - bowl coimmunoprecipitation, anti tag western blot (Del Signore et al., 2012) lin - drm coimmunoprecipitation, anti tag western blot (Del Signore et al., 2012) lin - odd coimmunoprecipitation, anti tag western blot (Del Signore et al., 2012) lin - sob coimmunoprecipitation, anti tag western blot (Del Signore et al., 2012)
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions lin allele Gene References linG1 Abd-B (Castelli-Gair, 1998) unspecified hh (Bokor and DiNardo, 1996) pan (Hatini et al., 2000) tor (Strecker et al., 1992)
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 69592 DroID - A comprehensive database of gene and protein interactions. • FBgn0002552 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 45325
Orthologs
OrthoDB Orthologs (30) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG6JQ4H1 Dipteran inclusive ortholog search EOG62828Q Insect inclusive ortholog search EOG6F4R63 Arthropod inclusive ortholog search EOG6J3TZ0 Metazoa inclusive ortholog search No orthologs identified
Orthologs in Drosophila Species (EOG6JQ4H1)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\lin     Drosophila simulans   Dsim\GD10612 Y   Drosophila sechellia   Dsec\GM21076 Y   Drosophila erecta   Dere\GG23396 Y   Drosophila yakuba   Dyak\GE19237 Y   Drosophila ananassae   Dana\GF11922 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA11188 Y   Drosophila persimilis   Dper\GL11676 Y   Drosophila willistoni   Dwil\GK10632 Y   Drosophila virilis   Dvir\GJ21304 Y   Drosophila mojavensis   Dmoj\GI18932 Y   Drosophila grimshawi   Dgri\GH23109 Y
Orthologs in non-Drosophila Dipterans (EOG62828Q)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL010444   Anopheles gambiae Malaria mosquito  Agam\AGAP010757   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ002947
Orthologs in non-Dipteran Insects (EOG6F4R63)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\GB52421   Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG000882   Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH12666   Atta cephalotes Leafcutter ant  Acep\ACEP18561   Camponotus floridanus Florida carpenter ant  Cflo\CFLO13979   Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL13425   Linepithema humile Argentine ant  Lhum\LH14974   Pogonomyrmex barbatus Red harvester ant  Pbar\PB19250   Solenopsis invicta Red fire ant  Sinv\SINV18807   Acyrthosiphon pisum Pea aphid  Apim\ACYPI061342   Acyrthosiphon pisum Pea aphid  Apim\ACYPI009023   Bombyx mori Silkmoth  Bmor\BGIBMGA008201   Pediculus humanus Human body louse  Phum\PHUM584750   Tribolium castaneum Red flour beetle  Tcas\TC011514
Orthologs in non-Insect Arthropods (EOG6J3TZ0)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\Akr1c13
Orthologs in non-Arthropod Metazoa (None identified)
No non-Arthropod Metazoa orthologies identified
Human Orthologs (0)
Gene OMIM HGNC
AAA Orthologs (11) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD10612 Drosophila sechellia Dsec\GM21076 Drosophila erecta Dere\GG23396 Drosophila yakuba Dyak\GE19237 Drosophila ananassae Dana\GF11922 Drosophila pseudoobscura pseudoobscura Dpse\GA11188 Drosophila persimilis Dper\GL11676 Drosophila willistoni Dwil\GK10632 Drosophila virilis Dvir\GJ21304 Drosophila mojavensis Dmoj\GI18932 Drosophila grimshawi Dgri\GH23109
Stocks & Reagents
Stocks Listed in FlyBase ( 6 )
Bloomington	7074 w*; P{UAS-lin.H}8 7087 w*; linG2/CyO 40939 y1 v1; P{TRiP.HMS02187}attP40 3099 cn1 lin2 bw1 sp1/CyO
Kyoto	106840 cn1 lin2 bw1 sp1/CyO
VDRC	v16801 w1118; P{GD1479}v16801
Genomic Clones ( 1 )
	BACR02C23 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 30 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	LD43682
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	GH14241 LD42375 LP18368 RE17707 RE43343 RE46339 RE46587 RH53226 RH54339 RH73070
Other clones	861 1082 17677 19058 35606 214309.42 214571.45 CK01.67B.D8 EK121527 EK121761 EK125710 EK129910 EK133653 EK146230 EK165612 EP15825 RP001011040 RP001039418 RP001049078
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0002552 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 45325
Antibody Information
	polyclonal (Hatini et al., 2000)
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of	Source for merge of: lin CG11770 (FlyBase, 1996-)
Additional comments	Source for merge of lin CG11770 was sequence comparison (date:000622). (FlyBase, 1996-)
Other Comments
	lin and bowl act as a binary switch to specify disc proper and peripodial epithelium fates respectively during early development of the wing primordium. (Nusinow et al., 2008) lin is required for patterning of the hindgut. (Iwaki et al., 2001) lin is essential for wg-dependent patterning in the embryonic dorsal epidermis. (Hatini et al., 2000) Genetic evidence demonstrates that lin is required for the function of the Abd-B protein, but not for the function of other Hox genes. In mutant embryos Abd-B protein expression is normal but incapable of promoting its normal functions: formation of the posterior spiracle and specification of the eighth abdominal denticle belt. (Castelli-Gair, 1998) wg and hh signaling account for all cell types across the dorsal epidermis, where lin regulates the late expression of wg. lin function is antagonized by hh. (Bokor and DiNardo, 1996) lin is able to suppress some aspects of the late wg phenotype and later the identity of some hh-dependent cell types. (Bokor et al., 1995) The role of lin in the regulation of run mRNA expression in the early embryo has been investigated. (Klingler and Gergen, 1993) wg and en expression patterns are studied in all known segment polarity mutants to investigate the requirement of other segment polarity genes in mediating the maintenance of wg and en. (van den Heuvel et al., 1993) Zygotically active locus involved in the terminal developmental program in the embryo. (Strecker et al., 1991)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_080076 RefSeq (Proteins) • NP_524815 DDBJ / EMBL / GenBank • AAF59024 AAF76228 AAX33526 ABA86400 AF272358 AI512046 AW943673 BT021378 DQ138794 Entrez Gene - A searchable database of RefSeq genes. • 45325 UniProtKB/Swiss-Prot • Q9V4Z9 UniProtKB/TrEMBL • Q2XY68
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Protein Lines (IPR024875)
Linkouts
	BioGRID - A database of protein and genetic interactions • 69592 DroID - A comprehensive database of gene and protein interactions. • FBgn0002552 DRSC - Results from RNAi screens. • FBgn0002552 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0002552 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG11770-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0002552 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 45325 Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution • /segment/lines1.htm InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 45325 modMine - Data generated by the modENCODE project. • FBgn0002552
Synonyms & Secondary IDs ( 4 )
Reported As
Symbol Synonym	CG11770 (Kim et al., 2004, Ni et al., 2010.12.1) Lin (Johansen et al., 2001) lin (Tao et al., 2007, Junion et al., 2007, Benítez et al., 2009, Zhai et al., 2009, Mulinari and Häcker, 2009, Brás-Pereira and Casares, 2008, Zhai et al., 2010)
Name Synonym	lines (Waldrop et al., 2006, Hatini and Nusinow, 2007, Bras-Pereira et al., 2006, Tao et al., 2007, DiNardo et al., 2008, Nusinow et al., 2008, Benítez et al., 2009, Greenberg and Hatini, 2009, Zhai et al., 2009, Mulinari and Häcker, 2009, Brás-Pereira and Casares, 2008, Grusche et al., 2011, Zhai et al., 2010, Del Signore et al., 2012)
Secondary FlyBase IDs
	FBgn0033346
References ( 76 )
Generate a list of	All references relating to this gene ( 76 )
List References by type	Research paper  ( 36 ) Supplementary material  ( 4 ) Review  ( 8 ) Personal communication to FlyBase  ( 5 ) Abstract  ( 17 ) FlyBase analysis  ( 1 ) Stock list  ( 1 ) DNA/RNA sequence record  ( 4 )
Recent research papers ( 2 )
	Del Signore et al., 2012, Mech. Dev. 129(5-8): 147--161 odd-skipped genes and lines organize the notum anterior-posterior axis using autonomous and non-autonomous mechanisms. [FBrf0219018] Grusche et al., 2011, Dev. Biol. 350(2): 255--266 The Salvador/Warts/Hippo pathway controls regenerative tissue growth in Drosophila melanogaster. [FBrf0212888] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2011 Show reviews ...