FlyBase Gene Report: Dmel\lin

General Information

Symbol

Dmel\lin

Species

D. melanogaster

Name

lines

Annotation Symbol

CG11770

Feature Type

protein_coding_gene

FlyBase ID

FBgn0002552

Gene Model Status

Current

Stock Availability

7 publicly available

Gene Snapshot

lines (lin) encodes a nuclear protein involved in developmental patterning and cell fate specification. The Odd-skipped family protein encoded by bowl binds to and destabilizes the product of lin in the nucleus. Converserly the Odd family protein encoded by drm stabilizes the product of bowl in the nucleus by outcompeting the binding of the product of lin to the product of bowl and localizing the product of lin to the cytoplasm. [Date last reviewed: 2019-03-14]

Other Summaries

Alliance
Auto summary
UniProtKB
Red Book
Interactive Fly

Key Links

Genomic Location

Cytogenetic map

44F6-44F7

Sequence location

2R:8,914,524..8,918,234 [+]

Recombination map

2-59

Sequence

Get Decorated FASTA

Genomic Maps

GBrowse JBrowse

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Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

GO Summary Ribbons

[Detailed GO annotations]

Protein Family (UniProt)

Belongs to the protein lines family. (Q9V4Z9)

Protein Signatures (InterPro)

Molecular Function (GO)
[Detailed GO annotations]

Experimental Evidence

protein binding

Predictions / Assertions

Summaries

Protein Function (UniProtKB)

Has a dual role as a segment polarity protein and as a modulator of the Abd-B protein. Required for Abd-B to activate the transcription of genes (including ems, cut and sal) that are involved in posterior spiracle morphogenesis. Also required for Abd-B to form an eighth abdominal denticle belt. Acts in a hierarchy downstream of drm and upstream of bowl during foregut and hindgut patterning and morphogenesis. Involved in cell rearrangement during elongation of the embryonic hindgut. Required to regulate expression of embryonic hindgut patterning genes in order to establish the large intestine and at least some rectum, and to repress small intestine fate. Required for late wingless (wg)-dependent cell fate specification in the dorsal embryonic epidermis. Acts in concert with wg to regulate expression of wg itself and also to regulate wg-target genes. May have a role in ventral epidermal patterning, independent of wg signaling.

(UniProt, Q9V4Z9)

Phenotypic Description (Red Book; Lindsley and Zimm 1992)

lin: lines (C. Nusslein-Volhard)

Embryonic lethal; small anterior portion of each segment deleted; A8, spiracles, and anal plates absent. Head abnormal.

Summary (Interactive Fly)

novel segment polarity gene - Lines is crucial for completing Wg signal transduction, acting downstream or in parallel to Armadillo

Interactive Fly

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the GBrowse view of Dmel\lin or the JBrowse view of Dmel\lin for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Comments on Gene Model

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.49

Sequence Ontology: Class of Gene

nuclear_gene

protein_coding_gene

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

lin-RA

FBtr0088651

NM_080076

3654

858

Additional Transcript Data and Comments

Reported size (kB)

3.416 (longest cDNA)

(Hatini et al., 2000)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

RefSeq ID

GenBank

lin-PA

FBpp0087732

96.3

858

4.96

NP_524815

AAF59024

Polypeptides with Identical Sequences

There is only one protein coding transcript and one polypeptide associated with this gene

Additional Polypeptide Data and Comments

Reported size (kDa)

858 (aa)

(Hatini et al., 2000)

Comments

External Data

Subunit Structure (UniProtKB)

Interacts with drm.

(UniProt, Q9V4Z9)

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\lin using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

lin_1

Linkouts

Gene Ontology (13 terms)

Molecular Function (1 term)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

protein binding

inferred from physical interaction with UniProtKB:Q9VQS6

(assigned by UniProt )

(Green et al., 2002)

Terms Based on Predictions or Assertions (0 terms)

Biological Process (10 terms)

Terms Based on Experimental Evidence (10 terms)

CV Term

Evidence

References

embryonic foregut morphogenesis