LSP-1α, Lsp1, LSP-1, DmeLSP1a, Larval serum protein 1 alpha
Gene model reviewed during 5.50
There is only one protein coding transcript and one polypeptide associated with this gene
The size of the protein was determined by in vitro translation.
Heterohexamer, composed of three subunits, alpha, beta and gamma.
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Lsp1α using the Feature Mapper tool.
GBrowse - Visual display of RNA-Seq signalsView Dmel\Lsp1α in GBrowse 2
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
copia is able to positively regulate expression from Lsp1α in transient DNA co-transfection assays.
Although X-linked Lsp1α is not dosage compensated (Roberts and Evans-Roberts, 1979b); however when relocated by transformation to an autosomal site or to an ectopic site on the X, the gene does show dosage compensation (Ghosh, Chatterje, Bunick, Manning and Lucchesi, 1989).
Lsp1 are three genes encoding three related polypeptides that combine in random hexamers to form LSP1, a heterogenous larval serum protein of 450,000 to 480,000 daltons (Wolfe, Akam and Roberts, 1977). LSP1 synthesized in fat body; appears early in third instar attaining peak levels at the white prepupal stage; level begins to decline at mid-pupal stage reaching base line about four days into adult life (Roberts, Wolfe and Akam, 1977). Highly homologous to one another and all three share amino-acid homology with LSP2. Antigenically related as well but antisera to LSP1 polypeptides do not crossreact with LSP2 (Brock and Roberts, 1980). Codes for the α polypeptide of LSP1; molecular weight 83,000 (Brock and Roberts, 1980).