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Gene Dmel\Lsp1α

General Information
Symbol	Dmel\Lsp1α	Species	D. melanogaster
Name	Larval serum protein 1 α	Annotation symbol	CG2559
Feature type	protein_coding_gene	FlyBase ID	FBgn0002562
Gene Model Status	Current	Stock availability	3 publicly available
Also Known As	LSP-1α, Lsp1, Lsp1alpha, Lsp1-α, DmeLSP1a
Genomic Location
Chromosome (arm)	X	Recombination map
Cytogenetic map	11A12-11A12	Sequence location	X:12,384,324..12,387,015 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Larval serum protein 1 α is referred to in FlyBase by the symbol Dmel\Lsp1α (CG2559, FBgn0002562). It is a protein_coding_gene from Drosophila melanogaster. It is reported to have molecular function: nutrient reservoir activity. The biological processes in which it is involved are not known. 7 alleles are reported. The phenotype of these alleles is annotated with: egg. It has one annotated transcript and one annotated polypeptide. Protein features are: Hemocyanin, C-terminal; Hemocyanin, N-terminal; Hemocyanin/hexamerin; Hemocyanin/hexamerin middle domain; Immunoglobulin E-set; Uncharacterised domain, di-copper centre. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of extremely high expression to a trough of no expression detected. Peak expression observed during late larval stages. Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: larval hindgut, larval fat body, larval salivary gland, larval trachea, larval carcass. Expression at moderate levels in the following post-embryonic organs or tissues: larval Malpighian tubules. Comments on Affy2 ProbeSet: ProbeSet 1631803_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of Lsp1alpha. Gene sequence location is X:12384324..12387015.
User Contributed Data
	Beta version, feedback welcome
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 11A12-11A12   Limits computationally determined from genome sequence between P{EP}EP1451&P{EP}EP1629 and P{EP}CG11138EP1313
Experimentally Determined Cytological Location
Cytogenetic map Notes References 11B-11B   (determined by in situ hybridisation)   (Brock and Roberts, 1983) 11A-11A   (determined by in situ hybridisation)   (Lepesant et al., 1982) 11A7-11A9   (determined by in situ hybridisation)   (Smith et al., 1981)
Experimentally Determined Recombination Data
Location
Left of (cM)	g
Right of (cM)	v
Notes	27/47 of the distance from v to g.
Gene Model & Products
Please see the GBrowse view of Dmel\Lsp1α for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.50
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Lsp1α-RA FBtr0073651  NM_078583   2625   816
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Lsp1α-PA   FBpp0073484   98.9   816   6.08     NP_511138   AAF48168
Additional Polypeptide Data & Comments
Reported size (kDa)	83 (kD) (Lepesant et al., 1982)
Comments	The size of the protein was determined by in vitro translation. (Lepesant et al., 1982)
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Hemocyanin/hexamerin middle domain (IPR000896) Hemocyanin, C-terminal (IPR005203) Hemocyanin, N-terminal (IPR005204) Uncharacterised domain, di-copper centre (IPR008922) Hemocyanin/hexamerin (IPR013788) Immunoglobulin E-set (IPR014756)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AE014298 AAF48168   AY069163   BT024223   CO181094   CO181143   CO181268   CO181650   CO181700   CO182788   CO182913   CO183520   CO184043   CO184635   CO185010   CO185182   CO192043   CO195927   CO195975   ES695609   ES695627   ES695628   ES695629   ES695633   ES695635   ES695638   ES695639   ES695640   ES695642   ES695644   ES695647   ES695651   ES695662   ES695664   ES695666   ES695677   ES696306   EY198569   X03368 CAA27066   X03872 CAA27506
UniProtKB/Swiss-Prot	P11995
UniProtKB/TrEMBL
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences	EPD - Eukarytoic Promoter Database, an annotated collection of POL II promoters • 11049
Expression Data
Transcript Expression
microinjection Stage Tissue/Position (including subcellular localization) Reference third instar larval stage     (Lepesant et al., 1982) northern blot Stage Tissue/Position (including subcellular localization) Reference second instar larval stage -- third instar larval stage   embryonic/larval fat body   (Powell et al., 1984)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
mass spectroscopy Stage Tissue/Position (including subcellular localization) Reference day 7 of adulthood -- day 49 of adulthood   adult heart   (Cammarato et al., 2011)
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
larval serum protein complex inferred from direct assay (Wolfe et al., 1977) lipid particle inferred from direct assay (Beller et al., 2006, Beller et al., 2006)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: larval hindgut, larval fat body, larval salivary gland, larval trachea, larval carcass. Expression at moderate levels in the following post-embryonic organs or tissues: larval Malpighian tubules. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    17.275 Larval Midgut    25.3 Larval Hindgut    2303.5 Larval Malpighian Tubules    230.8 Larval Fat Body    11264.4 Larval Salivary Gland    3605.6 Larval Trachea    740.65 Larval Carcass    610.55 Adult Head    8.4 Adult Eye    5.2 Adult Brain    5 Adult Thoracic-Abdominal Ganglion    3.9 Adult Crop    1.4 Adult Midgut    4.8 Adult Hindgut    2.8 Adult Malpighian Tubules    2.2 Adult Fat Body    10 Adult Salivary Gland    12.3 Adult Heart    9.875 Adult VirginFemale Spermatheca    2.1 Adult InseminatedFemale Spermatheca    3.8 Adult Ovary    1.6 Adult Testis    1.6 Adult Male Accessory Gland    3.7 Adult Carcass    13.2 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    17.275 Larval Midgut    25.3 Larval Hindgut  (2303.5) Larval Malpighian Tubules    230.8 Larval Fat Body  (11264.4) Larval Salivary Gland  (3605.6) Larval Trachea  (740.65) Larval Carcass  (610.55) Adult Head    8.4 Adult Eye    5.2 Adult Brain    5 Adult Thoracic-Abdominal Ganglion    3.9 Adult Crop    1.4 Adult Midgut    4.8 Adult Hindgut    2.8 Adult Malpighian Tubules    2.2 Adult Fat Body    10 Adult Salivary Gland    12.3 Adult Heart    9.875 Adult VirginFemale Spermatheca    2.1 Adult InseminatedFemale Spermatheca    3.8 Adult Ovary    1.6 Adult Testis    1.6 Adult Male Accessory Gland    3.7 Adult Carcass    13.2 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    17.275 Larval Midgut    25.3 Larval Hindgut  (2303.5) Larval Malpighian Tubules    230.8 Larval Fat Body  (11264.4) Larval Salivary Gland  (3605.6) Larval Trachea    740.65 Larval Carcass    610.55 Adult Head    8.4 Adult Eye    5.2 Adult Brain    5 Adult Thoracic-Abdominal Ganglion    3.9 Adult Crop    1.4 Adult Midgut    4.8 Adult Hindgut    2.8 Adult Malpighian Tubules    2.2 Adult Fat Body    10 Adult Salivary Gland    12.3 Adult Heart    9.875 Adult VirginFemale Spermatheca    2.1 Adult InseminatedFemale Spermatheca    3.8 Adult Ovary    1.6 Adult Testis    1.6 Adult Male Accessory Gland    3.7 Adult Carcass    13.2 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    17.275 Larval Midgut    25.3 Larval Hindgut    2303.5 Larval Malpighian Tubules    230.8 Larval Fat Body    11264.4 Larval Salivary Gland    3605.6 Larval Trachea    740.65 Larval Carcass    610.55 Adult Head    8.4 Adult Eye    5.2 Adult Brain    5 Adult Thoracic-Abdominal Ganglion    3.9 Adult Crop    1.4 Adult Midgut    4.8 Adult Hindgut    2.8 Adult Malpighian Tubules    2.2 Adult Fat Body    10 Adult Salivary Gland    12.3 Adult Heart    9.875 Adult VirginFemale Spermatheca    2.1 Adult InseminatedFemale Spermatheca    3.8 Adult Ovary    1.6 Adult Testis    1.6 Adult Male Accessory Gland    3.7 Adult Carcass    13.2 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    17.275 Larval Midgut    25.3 Larval Hindgut    2303.5 Larval Malpighian Tubules    230.8 Larval Fat Body    11264.4 Larval Salivary Gland    3605.6 Larval Trachea    740.65 Larval Carcass    610.55 Adult Head    8.4 Adult Eye    5.2 Adult Brain    5 Adult Thoracic-Abdominal Ganglion    3.9 Adult Crop    1.4 Adult Midgut    4.8 Adult Hindgut    2.8 Adult Malpighian Tubules    2.2 Adult Fat Body    10 Adult Salivary Gland    12.3 Adult Heart    9.875 Adult VirginFemale Spermatheca    2.1 Adult InseminatedFemale Spermatheca    3.8 Adult Ovary    1.6 Adult Testis    1.6 Adult Male Accessory Gland    3.7 Adult Carcass    13.2 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    17.275 Larval Midgut    25.3 Larval Hindgut  (2303.5) Larval Malpighian Tubules    230.8 Larval Fat Body  (11264.4) Larval Salivary Gland  (3605.6) Larval Trachea  740.65 Larval Carcass  610.55 Adult Head    8.4 Adult Eye    5.2 Adult Brain    5 Adult Thoracic-Abdominal Ganglion    3.9 Adult Crop    1.4 Adult Midgut    4.8 Adult Hindgut    2.8 Adult Malpighian Tubules    2.2 Adult Fat Body    10 Adult Salivary Gland    12.3 Adult Heart    9.875 Adult VirginFemale Spermatheca    2.1 Adult InseminatedFemale Spermatheca    3.8 Adult Ovary    1.6 Adult Testis    1.6 Adult Male Accessory Gland    3.7 Adult Carcass    13.2 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    17.275 Larval Midgut    25.3 Larval Hindgut  (2303.5) Larval Malpighian Tubules    230.8 Larval Fat Body  (11264.4) Larval Salivary Gland  (3605.6) Larval Trachea    740.65 Larval Carcass    610.55 Adult Head    8.4 Adult Eye    5.2 Adult Brain    5 Adult Thoracic-Abdominal Ganglion    3.9 Adult Crop    1.4 Adult Midgut    4.8 Adult Hindgut    2.8 Adult Malpighian Tubules    2.2 Adult Fat Body    10 Adult Salivary Gland    12.3 Adult Heart    9.875 Adult VirginFemale Spermatheca    2.1 Adult InseminatedFemale Spermatheca    3.8 Adult Ovary    1.6 Adult Testis    1.6 Adult Male Accessory Gland    3.7 Adult Carcass    13.2 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    17.275 Larval Midgut    25.3 Larval Hindgut    2303.5 Larval Malpighian Tubules    230.8 Larval Fat Body    11264.4 Larval Salivary Gland    3605.6 Larval Trachea    740.65 Larval Carcass    610.55 Adult Head    8.4 Adult Eye    5.2 Adult Brain    5 Adult Thoracic-Abdominal Ganglion    3.9 Adult Crop    1.4 Adult Midgut    4.8 Adult Hindgut    2.8 Adult Malpighian Tubules    2.2 Adult Fat Body    10 Adult Salivary Gland    12.3 Adult Heart    9.875 Adult VirginFemale Spermatheca    2.1 Adult InseminatedFemale Spermatheca    3.8 Adult Ovary    1.6 Adult Testis    1.6 Adult Male Accessory Gland    3.7 Adult Carcass    13.2 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    8.4   NA  Eye    5.2   NA  Brain    5   17.275  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    3.9   NA  Crop    1.4   no informative data  Midgut    4.8   2303.5  Hindgut    2.8   230.8  Malpighian Tubules    2.2   11264.4  Fat Body    no informative data   3605.6  Salivary Gland    no informative data   NA  Heart    9.875   740.65  Trachea    NA   NA  VirginFemale Spermatheca    2.1   NA  InseminatedFemale Spermatheca    3.8   NA  Ovary    1.6   NA  Testis    1.6   NA  Male Accessory Gland    3.7   610.55  Carcass    no informative data FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    29 central nervous system, larvae L3    32 central nervous system, pupae P8    12 head, virgin 1-day female    0 head, virgin 4-day female    0 head, virgin 20-day female    3 head, mated 1-day female    0 head, mated 4-day female    0 head, mated 20-day female    49 head, mated 1-day male    0 head, mated 4-day male    1 head, mated 20-day male    2 salivary gland, larvae L3 wandering    185 salivary gland, white prepupae    68 digestive system, larvae L3 wandering    156 digestive system, 1-day adult    1 digestive system, 4-day adult    3 digestive system, 20-day adult    0 fat body, larvae L3 wandering    22121 fat body, white prepupae    188 fat body, pupae P8    19 carcass, larvae L3 wandering    152 carcass, 1-day adult    7 carcass, 4-day adult    4 carcass, 20-day adult    3 ovary, virgin 4-day female    2 ovary, mated 4-day female    0 testis, mated 4-day male    1 accessory gland, mated 4-day male    102 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (29) central nervous system, larvae L3  (32) central nervous system, pupae P8    12 head, virgin 1-day female    0 head, virgin 4-day female    0 head, virgin 20-day female    3 head, mated 1-day female    0 head, mated 4-day female    0 head, mated 20-day female  (49) head, mated 1-day male    0 head, mated 4-day male    1 head, mated 20-day male    2 salivary gland, larvae L3 wandering  (185) salivary gland, white prepupae  (68) digestive system, larvae L3 wandering  (156) digestive system, 1-day adult    1 digestive system, 4-day adult    3 digestive system, 20-day adult    0 fat body, larvae L3 wandering  (22121) fat body, white prepupae  (188) fat body, pupae P8    19 carcass, larvae L3 wandering  (152) carcass, 1-day adult    7 carcass, 4-day adult    4 carcass, 20-day adult    3 ovary, virgin 4-day female    2 ovary, mated 4-day female    0 testis, mated 4-day male    1 accessory gland, mated 4-day male  (102) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    29 central nervous system, larvae L3    32 central nervous system, pupae P8    12 head, virgin 1-day female    0 head, virgin 4-day female    0 head, virgin 20-day female    3 head, mated 1-day female    0 head, mated 4-day female    0 head, mated 20-day female    49 head, mated 1-day male    0 head, mated 4-day male    1 head, mated 20-day male    2 salivary gland, larvae L3 wandering  (185) salivary gland, white prepupae    68 digestive system, larvae L3 wandering  (156) digestive system, 1-day adult    1 digestive system, 4-day adult    3 digestive system, 20-day adult    0 fat body, larvae L3 wandering  (22121) fat body, white prepupae  (188) fat body, pupae P8    19 carcass, larvae L3 wandering  (152) carcass, 1-day adult    7 carcass, 4-day adult    4 carcass, 20-day adult    3 ovary, virgin 4-day female    2 ovary, mated 4-day female    0 testis, mated 4-day male    1 accessory gland, mated 4-day male  102 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    29 central nervous system, larvae L3    32 central nervous system, pupae P8    12 head, virgin 1-day female    0 head, virgin 4-day female    0 head, virgin 20-day female    3 head, mated 1-day female    0 head, mated 4-day female    0 head, mated 20-day female    49 head, mated 1-day male    0 head, mated 4-day male    1 head, mated 20-day male    2 salivary gland, larvae L3 wandering    185 salivary gland, white prepupae    68 digestive system, larvae L3 wandering    156 digestive system, 1-day adult    1 digestive system, 4-day adult    3 digestive system, 20-day adult    0 fat body, larvae L3 wandering    22121 fat body, white prepupae    188 fat body, pupae P8    19 carcass, larvae L3 wandering    152 carcass, 1-day adult    7 carcass, 4-day adult    4 carcass, 20-day adult    3 ovary, virgin 4-day female    2 ovary, mated 4-day female    0 testis, mated 4-day male    1 accessory gland, mated 4-day male    102 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    29 central nervous system, larvae L3    32 central nervous system, pupae P8    12 head, virgin 1-day female    0 head, virgin 4-day female    0 head, virgin 20-day female    3 head, mated 1-day female    0 head, mated 4-day female    0 head, mated 20-day female    49 head, mated 1-day male    0 head, mated 4-day male    1 head, mated 20-day male    2 salivary gland, larvae L3 wandering    185 salivary gland, white prepupae    68 digestive system, larvae L3 wandering    156 digestive system, 1-day adult    1 digestive system, 4-day adult    3 digestive system, 20-day adult    0 fat body, larvae L3 wandering    22121 fat body, white prepupae    188 fat body, pupae P8    19 carcass, larvae L3 wandering    152 carcass, 1-day adult    7 carcass, 4-day adult    4 carcass, 20-day adult    3 ovary, virgin 4-day female    2 ovary, mated 4-day female    0 testis, mated 4-day male    1 accessory gland, mated 4-day male    102 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  29 central nervous system, larvae L3  32 central nervous system, pupae P8    12 head, virgin 1-day female    0 head, virgin 4-day female    0 head, virgin 20-day female    3 head, mated 1-day female    0 head, mated 4-day female    0 head, mated 20-day female  (49) head, mated 1-day male    0 head, mated 4-day male    1 head, mated 20-day male    2 salivary gland, larvae L3 wandering  (185) salivary gland, white prepupae  (68) digestive system, larvae L3 wandering  (156) digestive system, 1-day adult    1 digestive system, 4-day adult    3 digestive system, 20-day adult    0 fat body, larvae L3 wandering  (22121) fat body, white prepupae  (188) fat body, pupae P8    19 carcass, larvae L3 wandering  (152) carcass, 1-day adult    7 carcass, 4-day adult    4 carcass, 20-day adult    3 ovary, virgin 4-day female    2 ovary, mated 4-day female    0 testis, mated 4-day male    1 accessory gland, mated 4-day male  (102) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    29 central nervous system, larvae L3    32 central nervous system, pupae P8    12 head, virgin 1-day female    0 head, virgin 4-day female    0 head, virgin 20-day female    3 head, mated 1-day female    0 head, mated 4-day female    0 head, mated 20-day female    49 head, mated 1-day male    0 head, mated 4-day male    1 head, mated 20-day male    2 salivary gland, larvae L3 wandering  (185) salivary gland, white prepupae    68 digestive system, larvae L3 wandering  (156) digestive system, 1-day adult    1 digestive system, 4-day adult    3 digestive system, 20-day adult    0 fat body, larvae L3 wandering  (22121) fat body, white prepupae  (188) fat body, pupae P8    19 carcass, larvae L3 wandering  (152) carcass, 1-day adult    7 carcass, 4-day adult    4 carcass, 20-day adult    3 ovary, virgin 4-day female    2 ovary, mated 4-day female    0 testis, mated 4-day male    1 accessory gland, mated 4-day male  102 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    29 central nervous system, larvae L3    32 central nervous system, pupae P8    12 head, virgin 1-day female    0 head, virgin 4-day female    0 head, virgin 20-day female    3 head, mated 1-day female    0 head, mated 4-day female    0 head, mated 20-day female    49 head, mated 1-day male    0 head, mated 4-day male    1 head, mated 20-day male    2 salivary gland, larvae L3 wandering    185 salivary gland, white prepupae    68 digestive system, larvae L3 wandering    156 digestive system, 1-day adult    1 digestive system, 4-day adult    3 digestive system, 20-day adult    0 fat body, larvae L3 wandering    22121 fat body, white prepupae    188 fat body, pupae P8    19 carcass, larvae L3 wandering    152 carcass, 1-day adult    7 carcass, 4-day adult    4 carcass, 20-day adult    3 ovary, virgin 4-day female    2 ovary, mated 4-day female    0 testis, mated 4-day male    1 accessory gland, mated 4-day male    102 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of extremely high expression to a trough of no expression detected. Peak expression observed during late larval stages. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    0 embryo 10-12hr    0 embryo 12-14hr    0 embryo 14-16hr    0 embryo 16-18hr    0 embryo 18-20hr    0 embryo 20-22hr    0 embryo 22-24hr    0 larva L1    0 larva L2    0 larva L3 12hr old    476 larva L3 puffstage 1-2    10086 larva L3 puffstage 3-6    3264 larva L3 puffstage 7-9    320 white prepupae new    137 white prepupae 12hr    103 white prepupae 24hr    122 pupae 2d postWPP    122 pupae 3d postWPP    55 pupae 4d postWPP    41 adult male 01day    2 adult male 05day    1 adult male 30day    0 adult female 01day    5 adult female 05day    1 adult female 30day    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    0 embryo 10-12hr    0 embryo 12-14hr    0 embryo 14-16hr    0 embryo 16-18hr    0 embryo 18-20hr    0 embryo 20-22hr    0 embryo 22-24hr    0 larva L1    0 larva L2    0 larva L3 12hr old  (476) larva L3 puffstage 1-2  (10086) larva L3 puffstage 3-6  (3264) larva L3 puffstage 7-9  (320) white prepupae new  (137) white prepupae 12hr  (103) white prepupae 24hr  (122) pupae 2d postWPP  (122) pupae 3d postWPP  (55) pupae 4d postWPP  (41) adult male 01day    2 adult male 05day    1 adult male 30day    0 adult female 01day    5 adult female 05day    1 adult female 30day    1 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    0 embryo 10-12hr    0 embryo 12-14hr    0 embryo 14-16hr    0 embryo 16-18hr    0 embryo 18-20hr    0 embryo 20-22hr    0 embryo 22-24hr    0 larva L1    0 larva L2    0 larva L3 12hr old  (476) larva L3 puffstage 1-2  (10086) larva L3 puffstage 3-6  (3264) larva L3 puffstage 7-9  (320) white prepupae new  (137) white prepupae 12hr  103 white prepupae 24hr  (122) pupae 2d postWPP  (122) pupae 3d postWPP    55 pupae 4d postWPP    41 adult male 01day    2 adult male 05day    1 adult male 30day    0 adult female 01day    5 adult female 05day    1 adult female 30day    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    0 embryo 10-12hr    0 embryo 12-14hr    0 embryo 14-16hr    0 embryo 16-18hr    0 embryo 18-20hr    0 embryo 20-22hr    0 embryo 22-24hr    0 larva L1    0 larva L2    0 larva L3 12hr old    476 larva L3 puffstage 1-2    10086 larva L3 puffstage 3-6    3264 larva L3 puffstage 7-9    320 white prepupae new    137 white prepupae 12hr    103 white prepupae 24hr    122 pupae 2d postWPP    122 pupae 3d postWPP    55 pupae 4d postWPP    41 adult male 01day    2 adult male 05day    1 adult male 30day    0 adult female 01day    5 adult female 05day    1 adult female 30day    1 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    0 embryo 10-12hr    0 embryo 12-14hr    0 embryo 14-16hr    0 embryo 16-18hr    0 embryo 18-20hr    0 embryo 20-22hr    0 embryo 22-24hr    0 larva L1    0 larva L2    0 larva L3 12hr old    476 larva L3 puffstage 1-2    10086 larva L3 puffstage 3-6    3264 larva L3 puffstage 7-9    320 white prepupae new    137 white prepupae 12hr    103 white prepupae 24hr    122 pupae 2d postWPP    122 pupae 3d postWPP    55 pupae 4d postWPP    41 adult male 01day    2 adult male 05day    1 adult male 30day    0 adult female 01day    5 adult female 05day    1 adult female 30day    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    0 embryo 10-12hr    0 embryo 12-14hr    0 embryo 14-16hr    0 embryo 16-18hr    0 embryo 18-20hr    0 embryo 20-22hr    0 embryo 22-24hr    0 larva L1    0 larva L2    0 larva L3 12hr old  (476) larva L3 puffstage 1-2  (10086) larva L3 puffstage 3-6  (3264) larva L3 puffstage 7-9  (320) white prepupae new  (137) white prepupae 12hr  (103) white prepupae 24hr  (122) pupae 2d postWPP  (122) pupae 3d postWPP  (55) pupae 4d postWPP  (41) adult male 01day    2 adult male 05day    1 adult male 30day    0 adult female 01day    5 adult female 05day    1 adult female 30day    1 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    0 embryo 10-12hr    0 embryo 12-14hr    0 embryo 14-16hr    0 embryo 16-18hr    0 embryo 18-20hr    0 embryo 20-22hr    0 embryo 22-24hr    0 larva L1    0 larva L2    0 larva L3 12hr old  (476) larva L3 puffstage 1-2  (10086) larva L3 puffstage 3-6  (3264) larva L3 puffstage 7-9  (320) white prepupae new  137 white prepupae 12hr  103 white prepupae 24hr  122 pupae 2d postWPP  122 pupae 3d postWPP    55 pupae 4d postWPP    41 adult male 01day    2 adult male 05day    1 adult male 30day    0 adult female 01day    5 adult female 05day    1 adult female 30day    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    0 embryo 10-12hr    0 embryo 12-14hr    0 embryo 14-16hr    0 embryo 16-18hr    0 embryo 18-20hr    0 embryo 20-22hr    0 embryo 22-24hr    0 larva L1    0 larva L2    0 larva L3 12hr old    476 larva L3 puffstage 1-2    10086 larva L3 puffstage 3-6    3264 larva L3 puffstage 7-9    320 white prepupae new    137 white prepupae 12hr    103 white prepupae 24hr    122 pupae 2d postWPP    122 pupae 3d postWPP    55 pupae 4d postWPP    41 adult male 01day    2 adult male 05day    1 adult male 30day    0 adult female 01day    5 adult female 05day    1 adult female 30day    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    49 cold shock, 4-day adult    55 heat shock, 4-day adult    3715 Cadmium 50 mM 6 hrs, larvae L3    6529 Cadmium 50 mM 12 hrs, larvae L3    6935 Cadmium 50 mM 48 hrs, 4-day adult    4246 Cadmium 100 mM 48 hrs, 4-day adult    0 Copper 0.5 mM 12 hrs, larvae L3    8871 Copper 15 mM 48 hrs, 4-day adult    182 Zinc 5 mM 12 hrs, larvae L3    6670 Zinc 4.5 mM 48 hrs, 4-day adult    537 Ethanol 2.5% 3 hrs, larvae L3    9 Ethanol 5% 3 hrs, larvae L3    6540 Ethanol 10% 3 hrs, larvae L3    7035 Caffeine 1.5 mg/ml 4 hrs, larvae L3    7147 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    0 Caffeine 25 mg/ml 48 hrs, 4-day adult    761 Paraquat 5 mM 48 hrs, 4-day adult    0 Paraquat 10 mM 48 hrs, 4-day adult    4 Rotenone 2 μg 12 hrs, larvae L3    5682 Rotenone 8 μg 12 hrs, larvae L3    3823 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult  (49) cold shock, 4-day adult  (55) heat shock, 4-day adult  (3715) Cadmium 50 mM 6 hrs, larvae L3  (6529) Cadmium 50 mM 12 hrs, larvae L3  (6935) Cadmium 50 mM 48 hrs, 4-day adult  (4246) Cadmium 100 mM 48 hrs, 4-day adult    0 Copper 0.5 mM 12 hrs, larvae L3  (8871) Copper 15 mM 48 hrs, 4-day adult  (182) Zinc 5 mM 12 hrs, larvae L3  (6670) Zinc 4.5 mM 48 hrs, 4-day adult  (537) Ethanol 2.5% 3 hrs, larvae L3    9 Ethanol 5% 3 hrs, larvae L3  (6540) Ethanol 10% 3 hrs, larvae L3  (7035) Caffeine 1.5 mg/ml 4 hrs, larvae L3  (7147) Caffeine 2.5 mg/ml 48 hrs, 4-day adult    0 Caffeine 25 mg/ml 48 hrs, 4-day adult  (761) Paraquat 5 mM 48 hrs, 4-day adult    0 Paraquat 10 mM 48 hrs, 4-day adult    4 Rotenone 2 μg 12 hrs, larvae L3  (5682) Rotenone 8 μg 12 hrs, larvae L3  (3823) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    49 cold shock, 4-day adult    55 heat shock, 4-day adult  (3715) Cadmium 50 mM 6 hrs, larvae L3  (6529) Cadmium 50 mM 12 hrs, larvae L3  (6935) Cadmium 50 mM 48 hrs, 4-day adult  (4246) Cadmium 100 mM 48 hrs, 4-day adult    0 Copper 0.5 mM 12 hrs, larvae L3  (8871) Copper 15 mM 48 hrs, 4-day adult  (182) Zinc 5 mM 12 hrs, larvae L3  (6670) Zinc 4.5 mM 48 hrs, 4-day adult  (537) Ethanol 2.5% 3 hrs, larvae L3    9 Ethanol 5% 3 hrs, larvae L3  (6540) Ethanol 10% 3 hrs, larvae L3  (7035) Caffeine 1.5 mg/ml 4 hrs, larvae L3  (7147) Caffeine 2.5 mg/ml 48 hrs, 4-day adult    0 Caffeine 25 mg/ml 48 hrs, 4-day adult  (761) Paraquat 5 mM 48 hrs, 4-day adult    0 Paraquat 10 mM 48 hrs, 4-day adult    4 Rotenone 2 μg 12 hrs, larvae L3  (5682) Rotenone 8 μg 12 hrs, larvae L3  (3823) Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    49 cold shock, 4-day adult    55 heat shock, 4-day adult    3715 Cadmium 50 mM 6 hrs, larvae L3    6529 Cadmium 50 mM 12 hrs, larvae L3    6935 Cadmium 50 mM 48 hrs, 4-day adult    4246 Cadmium 100 mM 48 hrs, 4-day adult    0 Copper 0.5 mM 12 hrs, larvae L3    8871 Copper 15 mM 48 hrs, 4-day adult    182 Zinc 5 mM 12 hrs, larvae L3    6670 Zinc 4.5 mM 48 hrs, 4-day adult    537 Ethanol 2.5% 3 hrs, larvae L3    9 Ethanol 5% 3 hrs, larvae L3    6540 Ethanol 10% 3 hrs, larvae L3    7035 Caffeine 1.5 mg/ml 4 hrs, larvae L3    7147 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    0 Caffeine 25 mg/ml 48 hrs, 4-day adult    761 Paraquat 5 mM 48 hrs, 4-day adult    0 Paraquat 10 mM 48 hrs, 4-day adult    4 Rotenone 2 μg 12 hrs, larvae L3    5682 Rotenone 8 μg 12 hrs, larvae L3    3823 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    49 cold shock, 4-day adult    55 heat shock, 4-day adult    3715 Cadmium 50 mM 6 hrs, larvae L3    6529 Cadmium 50 mM 12 hrs, larvae L3    6935 Cadmium 50 mM 48 hrs, 4-day adult    4246 Cadmium 100 mM 48 hrs, 4-day adult    0 Copper 0.5 mM 12 hrs, larvae L3    8871 Copper 15 mM 48 hrs, 4-day adult    182 Zinc 5 mM 12 hrs, larvae L3    6670 Zinc 4.5 mM 48 hrs, 4-day adult    537 Ethanol 2.5% 3 hrs, larvae L3    9 Ethanol 5% 3 hrs, larvae L3    6540 Ethanol 10% 3 hrs, larvae L3    7035 Caffeine 1.5 mg/ml 4 hrs, larvae L3    7147 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    0 Caffeine 25 mg/ml 48 hrs, 4-day adult    761 Paraquat 5 mM 48 hrs, 4-day adult    0 Paraquat 10 mM 48 hrs, 4-day adult    4 Rotenone 2 μg 12 hrs, larvae L3    5682 Rotenone 8 μg 12 hrs, larvae L3    3823 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult  (49) cold shock, 4-day adult  (55) heat shock, 4-day adult  (3715) Cadmium 50 mM 6 hrs, larvae L3  (6529) Cadmium 50 mM 12 hrs, larvae L3  (6935) Cadmium 50 mM 48 hrs, 4-day adult  (4246) Cadmium 100 mM 48 hrs, 4-day adult    0 Copper 0.5 mM 12 hrs, larvae L3  (8871) Copper 15 mM 48 hrs, 4-day adult  (182) Zinc 5 mM 12 hrs, larvae L3  (6670) Zinc 4.5 mM 48 hrs, 4-day adult  (537) Ethanol 2.5% 3 hrs, larvae L3    9 Ethanol 5% 3 hrs, larvae L3  (6540) Ethanol 10% 3 hrs, larvae L3  (7035) Caffeine 1.5 mg/ml 4 hrs, larvae L3  (7147) Caffeine 2.5 mg/ml 48 hrs, 4-day adult    0 Caffeine 25 mg/ml 48 hrs, 4-day adult  (761) Paraquat 5 mM 48 hrs, 4-day adult    0 Paraquat 10 mM 48 hrs, 4-day adult    4 Rotenone 2 μg 12 hrs, larvae L3  (5682) Rotenone 8 μg 12 hrs, larvae L3  (3823) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    49 cold shock, 4-day adult    55 heat shock, 4-day adult  (3715) Cadmium 50 mM 6 hrs, larvae L3  (6529) Cadmium 50 mM 12 hrs, larvae L3  (6935) Cadmium 50 mM 48 hrs, 4-day adult  (4246) Cadmium 100 mM 48 hrs, 4-day adult    0 Copper 0.5 mM 12 hrs, larvae L3  (8871) Copper 15 mM 48 hrs, 4-day adult  (182) Zinc 5 mM 12 hrs, larvae L3  (6670) Zinc 4.5 mM 48 hrs, 4-day adult  (537) Ethanol 2.5% 3 hrs, larvae L3    9 Ethanol 5% 3 hrs, larvae L3  (6540) Ethanol 10% 3 hrs, larvae L3  (7035) Caffeine 1.5 mg/ml 4 hrs, larvae L3  (7147) Caffeine 2.5 mg/ml 48 hrs, 4-day adult    0 Caffeine 25 mg/ml 48 hrs, 4-day adult  (761) Paraquat 5 mM 48 hrs, 4-day adult    0 Paraquat 10 mM 48 hrs, 4-day adult    4 Rotenone 2 μg 12 hrs, larvae L3  (5682) Rotenone 8 μg 12 hrs, larvae L3  (3823) Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    49 cold shock, 4-day adult    55 heat shock, 4-day adult    3715 Cadmium 50 mM 6 hrs, larvae L3    6529 Cadmium 50 mM 12 hrs, larvae L3    6935 Cadmium 50 mM 48 hrs, 4-day adult    4246 Cadmium 100 mM 48 hrs, 4-day adult    0 Copper 0.5 mM 12 hrs, larvae L3    8871 Copper 15 mM 48 hrs, 4-day adult    182 Zinc 5 mM 12 hrs, larvae L3    6670 Zinc 4.5 mM 48 hrs, 4-day adult    537 Ethanol 2.5% 3 hrs, larvae L3    9 Ethanol 5% 3 hrs, larvae L3    6540 Ethanol 10% 3 hrs, larvae L3    7035 Caffeine 1.5 mg/ml 4 hrs, larvae L3    7147 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    0 Caffeine 25 mg/ml 48 hrs, 4-day adult    761 Paraquat 5 mM 48 hrs, 4-day adult    0 Paraquat 10 mM 48 hrs, 4-day adult    4 Rotenone 2 μg 12 hrs, larvae L3    5682 Rotenone 8 μg 12 hrs, larvae L3    3823 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_04
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0002562 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG2559-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele viable Lsp1αo viable, with Scer\GAL4pnr-MD237 Lsp1αGD6490 Sterility Allele fertile Lsp1αo Other Phenotypes Allele electrophoretic variant Lsp1αF Lsp1αS1 Lsp1αS2 Phenotype manifest in Allele egg Lsp1αo
Classical Alleles ( 4 )
For All Classical Alleles Show
Allele of Lsp1α Class Mutagen Stocks Known lesion Lsp1αF natural population 0 -- Lsp1αo loss of function allele 0 Yes Lsp1αS1 natural population 0 -- Lsp1αS2 natural population 0 --
Alleles Carried on Transgenic Constructs ( 3 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Lsp1α Class Mutagen Stocks Known lesion Lsp1αGD17784 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Lsp1αGD6490 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Lsp1αKK106904 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes
Aneuploid Aberrations
Disrupted in	Df(1)Exel6244 (Ryder, 2004.4.26) Df(1)HF368 (Roberts and Evans-Roberts, 1979)
Not disrupted in	Df(1)v65b (Roberts and Evans-Roberts, 1979)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data reporter construct P{CAT.LSP1α} No P{αlacZ} No characterization construct P{LSPαHGST} NA P{αCYB2B1} NA
Insertions
	Type of insertions Name Expression data
Gene Ontology: Function, Process & Cellular Component ( 4 unique terms )
Terms Based on Experimental Evidence ( 2 terms )
Molecular Function ( 0 terms)
Biological Process ( 0 terms)
Cellular Component
CV term Evidence References
larval serum protein complex inferred from direct assay (Wolfe et al., 1977) lipid particle inferred from direct assay (Beller et al., 2006, Beller et al., 2006)
Terms Based on Predictions or Assertions ( 3 terms )
Molecular Function
CV term Evidence References
nutrient reservoir activity non-traceable author statement (Swiss-Prot Project Members, 1989.10.1)
Biological Process ( 0 terms)
Cellular Component
CV term Evidence References
extracellular region non-traceable author statement (Swiss-Prot Project Members, 1989.10.1) larval serum protein complex inferred from sequence or structural similarity with EMBL:M76480 (FlyBase, 1992-)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Lsp1α allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 58598 DroID - A comprehensive database of gene and protein interactions. • FBgn0002562 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 32199
Orthologs
OrthoDB Orthologs (4) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG60GD97 Dipteran inclusive ortholog search No orthologs identified Insect inclusive ortholog search No orthologs identified Arthropod inclusive ortholog search No orthologs identified Metazoa inclusive ortholog search No orthologs identified
Orthologs in Drosophila Species (EOG60GD97)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\Lsp1α     Drosophila simulans   Dsim\GD17082 Y   Drosophila erecta   Dere\GG17724 Y   Drosophila yakuba   Dyak\GE17014 Y
Orthologs in non-Drosophila Dipterans (None identified)
No non-Drosophilid orthologies identified
Orthologs in non-Dipteran Insects (None identified)
No non-Dipteran orthologies identified
Orthologs in non-Insect Arthropods (None identified)
No non-Insect Arthropod orthologies identified
Orthologs in non-Arthropod Metazoa (None identified)
No non-Arthropod Metazoa orthologies identified
Human Orthologs (0)
Gene OMIM HGNC
AAA Orthologs (6) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD17082 Drosophila erecta Dere\GG17724 Drosophila yakuba Dyak\GE17014 Drosophila ananassae Dana\GF16081 Drosophila pseudoobscura pseudoobscura Dpse\GA27203 Drosophila mojavensis Dmoj\GI23074
Stocks & Reagents
Stocks Listed in FlyBase ( 3 )
VDRC	v101101 P{KK106904}VIE-260B v14898 w1118; P{GD6490}v14898 v52353 w1118; P{GD17784}v52353/CyO
Genomic Clones ( 2 )
	BACR05L04 BACR48G08 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 36 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	GH19329 LP18812
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones
Other clones	DMG2-chrX.13.018.a EC13533 EC13621 EC13925 EC14786 EC14850 EC24028 EC24273 EC25901 EC26985 EC28352 EC29115 EC29862 EC32704 EC43562 EC43785 RC0-DP0003-150700-021-A05 RC0-DP0003-150700-021-B04 RC0-DP0003-150700-021-G01 RC0-DP0003-150700-021-G02 RC0-DP0003-150700-021-G06 RC0-DP0003-150700-021-H07 RC0-DP0003-150700-022-A01 RC0-DP0003-150700-022-A09 RC0-DP0003-150700-022-A11 RC0-DP0003-150700-022-A12 RC0-DP0003-150700-022-B09 RC0-DP0003-150700-022-C01 RC0-DP0003-150700-022-C09 RC0-DP0003-150700-022-D07 RC0-DP0003-150700-022-G08 RC0-DP0003-150700-022-G12 RC0-DP0003-150700-022-H03 RC0-DP0004-150700-011-D07
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0002562 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 32199
Antibody Information
Other Information
Discoverer
	Evans-Roberts, 1977.
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of
Additional comments
Other Comments
	Ecdysteroid-regulated gene. (Andres et al., 1993) copia is able to positively regulate expression from Lsp1α in transient DNA co-transfection assays. (Bryant et al., 1991) 5' flanking sequences of the Lsp1α, Lsp1β and Lsp1γ genes have been sequenced and compared. (Delaney et al., 1986) A D.melanogaster Lsp1α probe has been used to identify the site of the Lsp1α gene in a number of Drosophila species. (Brock and Roberts, 1983) Lsp1α, Lsp1β, Lsp1γ and Lsp2 mRNAs have been purified from the third larval instar fat body and translated in vitro. (Sato et al., 1982) Although X-linked Lsp1α is not dosage compensated (Roberts and Evans-Roberts, 1979b); however when relocated by transformation to an autosomal site or to an ectopic site on the X, the gene does show dosage compensation (Ghosh, Chatterje, Bunick, Manning and Lucchesi, 1989).   Lsp1 are three genes encoding three related polypeptides that combine in random hexamers to form LSP1, a heterogenous larval serum protein of 450,000 to 480,000 daltons (Wolfe, Akam and Roberts, 1977). LSP1 synthesized in fat body; appears early in third instar attaining peak levels at the white prepupal stage; level begins to decline at mid-pupal stage reaching base line about four days into adult life (Roberts, Wolfe and Akam, 1977). Highly homologous to one another and all three share amino-acid homology with LSP2. Antigenically related as well but antisera to LSP1 polypeptides do not crossreact with LSP2 (Brock and Roberts, 1980). Codes for the α polypeptide of LSP1; molecular weight 83,000 (Brock and Roberts, 1980).
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_078583 RefSeq (Proteins) • NP_511138 DDBJ / EMBL / GenBank • AAF48168 CAA27066 CAA27506 X03368 X03872 Entrez Gene - A searchable database of RefSeq genes. • 32199 UniProtKB/Swiss-Prot • P11995
Other Crossreferences
	EPD - Eukarytoic Promoter Database, an annotated collection of POL II promoters • 11049 InterPro domains - A database of protein families, domains, and functional sites • Hemocyanin/hexamerin middle domain (IPR000896) Hemocyanin, C-terminal (IPR005203) Hemocyanin, N-terminal (IPR005204) Uncharacterised domain, di-copper centre (IPR008922) Hemocyanin/hexamerin (IPR013788) Immunoglobulin E-set (IPR014756)
Linkouts
	BioGRID - A database of protein and genetic interactions • 58598 DroID - A comprehensive database of gene and protein interactions. • FBgn0002562 DRSC - Results from RNAi screens. • FBgn0002562 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0002562 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG2559-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0002562 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 32199 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 32199 modMine - Data generated by the modENCODE project. • FBgn0002562
Synonyms & Secondary IDs ( 17 )
Reported As
Symbol Synonym	CG2559 (Fulton et al., 2001, Beller et al., 2006, Herranz et al., 2012, Lebo et al., 2009, Keleman et al., 2009.8.5, Cammarato et al., 2011) DmeLSP1a (Burmester, 2001, Burmester et al., 1998) Lsp1 (Kern and Begun, 2005, Korochkina et al., 1997, Zraly et al., 2006) LSP-1 (Chiang and Kurnit, 2003) LSP 1 (Riddiford, 1993) LSP1 (Liu et al., 2007) Lsp1alpha (Gonzalez et al., 2002, Beller et al., 2006, Beller et al., 2006, Kalajdzic et al., 2012) Lsp1-α (Chiang and Kurnit, 2003) LSP-1α (Burmester et al., 1999, Roberts et al., 1998, Maschat et al., 1990, Deutsch et al., 1989, Sato et al., 1982) Lsp-1α (Andres et al., 1993, Roberts et al., 1991, Chawla and Sokol, 2012) LSP1α (Freeman and Glover, 1987, Davies et al., 1986) LSP1-α (Ghosh et al., 1992) LSP-1 α (Brock and Roberts, 1983) Lsp1α (Xun et al., 2009, Weake and Scott, 2007, Fernández-Ayala et al., 2010)
Name Synonym	Larval serum protein 1 alpha (Lebo et al., 2009, Cammarato et al., 2011) Larval serum protein 1 α (Xun et al., 2009) Larval serum protein one α (Weake and Scott, 2007)
Secondary FlyBase IDs
References ( 64 )
Generate a list of	All references relating to this gene ( 64 )
List References by type	Research paper  ( 46 ) Supplementary material  ( 4 ) Review  ( 3 ) Personal communication to FlyBase  ( 5 ) Abstract  ( 1 ) FlyBase analysis  ( 1 ) Protein sequence record  ( 1 ) Curated genome annotation  ( 2 ) Letter  ( 1 )
Recent research papers ( 4 )
	Chawla and Sokol, 2012, Development 139(10): 1788--1797 Hormonal activation of let-7-C microRNAs via EcR is required for adult Drosophila melanogaster morphology and function. [FBrf0218077] Fabian et al., 2012, Mol. Ecol. 21(19): 4748--4769 Genome-wide patterns of latitudinal differentiation among populations of Drosophila melanogaster from North America. [FBrf0219505] Herranz et al., 2012, BMC Genomics 13: 52 Microgravity simulation by diamagnetic levitation: effects of a strong gradient magnetic field on the transcriptional profile of Drosophila melanogaster. [FBrf0217750] Kalajdzic et al., 2012, PLoS ONE 7(6): e40296 Use of mutagenesis, genetic mapping and next generation transcriptomics to investigate insecticide resistance mechanisms. [FBrf0218826] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2011 Show reviews ...