FB2020_06, released Dec 22, 2020
Gene: Dmel\Lsp1β
FB2020_06, released Dec 22, 2020
Gene: Dmel\Lsp1β
Gene: Dmel\Lsp1β
Gene: Dmel\Lsp1β
LSP-1β, Lsp1, LSP-1, Larval serum protein 1 beta, Lsp1β
Please see the JBrowse view of Dmel\Lsp1β for information on other features
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Gene model reviewed during 5.45
Gene model reviewed during 5.56
2.7 (sequence analysis)
2.7 (unknown)
Heterohexamer, composed of three subunits, alpha, beta and gamma.
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Lsp1β using the Feature Mapper tool.
The expression of Lsp1α, Lsp1β, Lsp1γ, and Lsp2 proteins and transcripts were compared by in vitro translation of mRNAs isolated from third instar larval fat body, and by Northern analysis of cytoplasmic and nuclear RNAs of second and third instar larval fat body. Lsp1α, Lsp1β, Lsp1γ, and Lsp2 proteins appear at the same 4 hr, transcript levels are at maximum, and all 4 polypeptides are synthesized at about equal amounts. However, Lsp1α, Lsp1β, and Lsp1γ proteins decline and are not synthesized at 92 hr, although there is still Lsp1α, Lsp1β, and Lsp1γ mRNA available at 96 hr. Lsp1α, Lsp1β and Lsp1γ subunit synthesis ceases before that of Lsp2 synthesis; the latter is no longer detected4 hr, transcript levels are at maximum, and all 4 polypeptides are synthesized at about equal amounts. However, Lsp1α, Lsp1β, and Lsp1γ proteins decline and are not synthesized at 92 hr, although there is still Lsp1α, Lsp1β, and Lsp1γ mRNA available at 96 hr. Lsp1α, Lsp1β and Lsp1γ subunit synthesis ceases before that of Lsp2 synthesis; the latter is no longer detected
As deduced by in vitro translation of polyA RNA, Lsp1β is detected within an hour after the second larval molt and is present through third larval instar. It is almost undetectable by the prepupal stage. Levels of this transcript did not increase in response to ecdysone supplement.
GBrowse - Visual display of RNA-Seq signals
View Dmel\Lsp1β in GBrowse 22-1.5
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Source for identity of: Lsp1β CG4178
Area matching Drosophila larval serum protein 1 beta subunit gene (inverted), Acc. No. U63556.
Nucleotide sequence of Lsp1β and the amino acid sequence of protein is determined and analysed.
Ecdysteroid-regulated gene.
A D.melanogaster Lsp1β probe has been used to identify the site of the Lsp1β gene in a number of Drosophila species.
Dp(2;2;2;2;2)S probably carries five copies of the Lsp1β gene (Brock and Roberts, 1981).
Lsp1 are three genes encoding three related polypeptides that combine in random hexamers to form LSP1, a heterogenous larval serum protein of 450,000 to 480,000 daltons (Wolfe, Akam and Roberts, 1977). LSP1 synthesized in fat body; appears early in third instar attaining peak levels at the white prepupal stage; level begins to decline at mid-pupal stage reaching base line about four days into adult life (Roberts et al., 1977). Highly homologous to one another and all three share amino-acid homology with LSP2. Antigenically related as well but antisera to LSP1 polypeptides do not crossreact with LSP2 (Brock and Roberts, 1980). Codes for the polypeptide of LSP1β, a phosphorylated polypeptide of molecular weight 80,000 (Brock and Roberts, 1980).
