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Gene Dmel\Mal-A1

General Information
Symbol	Dmel\Mal-A1	Species	D. melanogaster
Name	Maltase A1	Annotation symbol	CG8696
Feature type	protein_coding_gene	FlyBase ID	FBgn0002570
Gene Model Status	Current	Stock availability	4 publicly available
Also Known As	LvpH, H, mal_A1
Genomic Location
Chromosome (arm)	2R	Recombination map
Cytogenetic map	44D1-44D1	Sequence location	2R:4,337,166..4,339,404 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Maltase A1 is referred to in FlyBase by the symbol Dmel\Mal-A1 (CG8696, FBgn0002570). It is a protein_coding_gene from Drosophila melanogaster. It is reported to have molecular function: alpha-glucosidase activity. It is reported to be involved in the biological process: glucose metabolic process. 3 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. Protein features are: Alpha amylase; Glycoside hydrolase, subgroup, catalytic domain; Glycoside hydrolase, superfamily; Glycosyl hydrolase, family 13, all-beta; Glycosyl hydrolase, family 13, catalytic domain; Glycosyl hydrolase, family 13, subfamily, catalytic domain. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of very low expression. Peak expression observed within 18-24 hour embryonic stages, during early larval stages, in stages of adults of both sexes. Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: larval/adult midgut. Comments on Affy2 ProbeSet: ProbeSet 1639401_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of LvpH. Gene sequence location is 2R:4337166..4339404.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2011_10
FB2012_01	Sequence features HFA07461 BKN24408
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 44D1-44D1   Limits computationally determined from genome sequence between P{lacW}Rs1k09514&P{lacW}l(2)k03110k03110 and P{lacW}Vps25k08904&P{lacW}ptck02507
Experimentally Determined Cytological Location
Cytogenetic map Notes References 44D-44D   Inferred from proximity to Lcp gene cluster.   (Snyder et al., 1982)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\Mal-A1 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Mal-A1-RA FBtr0088759  NM_057279   1824   577
Additional Transcript Data & Comments
Reported size (kB)	1.7 (northern blot) (Snyder and Davidson, 1983)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Mal-A1-PA   FBpp0087838   66.4   577   4.52     NP_476627   AAF59089
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Glycosyl hydrolase, family 13, catalytic domain (IPR006047) Glycosyl hydrolase, family 13, subfamily, catalytic domain (IPR006589) Glycoside hydrolase, subgroup, catalytic domain (IPR013781) Glycoside hydrolase, superfamily (IPR017853) Alpha amylase (IPR015902) Glycosyl hydrolase, family 13, all-beta (IPR013780)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA697991   AE013599 AAF59089   AC005451   AI295803   AI386572   AI517021   AY070626   BI173333   BI228916   BI366411   BI372255   CO177254   CO194487   CO285537   CO293062   CO294532   CO340043   EC058190   EC201198   EC211450   EC224361   EC255791   EV582628   EV583038   EV584248   EV585465   EV586911   EV587592   EV589505   EV591897   EV593311   EV595043   EV598546   EV599304   EV599672   EV600284   GH759126   GH789937   GH806788   GH811910   GH843564   GH848782   GH861140   GH862753   GH865565   GH890871   GH909468   GH918391   GH934577   V00204 CAA23491
UniProtKB/Swiss-Prot	P07190
UniProtKB/TrEMBL
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences	EPD - Eukarytoic Promoter Database, an annotated collection of POL II promoters • 07033 07034
Expression Data
Transcript Expression
northern blot Stage Tissue/Position (including subcellular localization) Reference first instar larval stage     (Snyder and Davidson, 1983) second instar larval stage     (Snyder and Davidson, 1983) early third instar larval stage   organism   (Snyder and Davidson, 1983) adult stage     (Snyder and Davidson, 1983)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0002570    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0002570 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of very low expression. Peak expression observed within 18-24 hour embryonic stages, during early larval stages, in stages of adults of both sexes. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0002570 expression level Developmental Stage   Expression Level embryo 00-02hr    18 embryo 02-04hr    12 embryo 04-06hr    29 embryo 06-08hr    83 embryo 08-10hr    414 embryo 10-12hr    1003 embryo 12-14hr    643 embryo 14-16hr    231 embryo 16-18hr    187 embryo 18-20hr    2360 embryo 20-22hr    13997 embryo 22-24hr    17081 larva L1    20926 larva L2    27003 larva L3 12hr old    13834 larva L3 puffstage 1-2    4378 larva L3 puffstage 3-6    1938 larva L3 puffstage 7-9    570 white prepupae new    196 white prepupae 12hr    53 white prepupae 24hr    19 pupae 2d postWPP    17 pupae 3d postWPP    11 pupae 4d postWPP    6997 adult male 01day    37297 adult male 05day    32953 adult male 30day    44832 adult female 01day    27819 adult female 05day    7826 adult female 30day    5767 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr    18 embryo 02-04hr    12 embryo 04-06hr    29 embryo 06-08hr    83 embryo 08-10hr  (414) embryo 10-12hr  (1003) embryo 12-14hr  (643) embryo 14-16hr  (231) embryo 16-18hr  (187) embryo 18-20hr  (2360) embryo 20-22hr  (13997) embryo 22-24hr  (17081) larva L1  (20926) larva L2  (27003) larva L3 12hr old  (13834) larva L3 puffstage 1-2  (4378) larva L3 puffstage 3-6  (1938) larva L3 puffstage 7-9  (570) white prepupae new  (196) white prepupae 12hr    53 white prepupae 24hr    19 pupae 2d postWPP    17 pupae 3d postWPP    11 pupae 4d postWPP  (6997) adult male 01day  (37297) adult male 05day  (32953) adult male 30day  (44832) adult female 01day  (27819) adult female 05day  (7826) adult female 30day  (5767) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    18 embryo 02-04hr    12 embryo 04-06hr    29 embryo 06-08hr    83 embryo 08-10hr    414 embryo 10-12hr    1003 embryo 12-14hr    643 embryo 14-16hr    231 embryo 16-18hr    187 embryo 18-20hr  (2360) embryo 20-22hr  (13997) embryo 22-24hr  (17081) larva L1  (20926) larva L2  (27003) larva L3 12hr old  (13834) larva L3 puffstage 1-2  (4378) larva L3 puffstage 3-6  (1938) larva L3 puffstage 7-9    570 white prepupae new    196 white prepupae 12hr    53 white prepupae 24hr    19 pupae 2d postWPP    17 pupae 3d postWPP    11 pupae 4d postWPP  (6997) adult male 01day  (37297) adult male 05day  (32953) adult male 30day  (44832) adult female 01day  (27819) adult female 05day  (7826) adult female 30day  (5767) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    18 embryo 02-04hr    12 embryo 04-06hr    29 embryo 06-08hr    83 embryo 08-10hr    414 embryo 10-12hr    1003 embryo 12-14hr    643 embryo 14-16hr    231 embryo 16-18hr    187 embryo 18-20hr    2360 embryo 20-22hr  (13997) embryo 22-24hr  (17081) larva L1  (20926) larva L2  (27003) larva L3 12hr old  (13834) larva L3 puffstage 1-2    4378 larva L3 puffstage 3-6    1938 larva L3 puffstage 7-9    570 white prepupae new    196 white prepupae 12hr    53 white prepupae 24hr    19 pupae 2d postWPP    17 pupae 3d postWPP    11 pupae 4d postWPP    6997 adult male 01day  (37297) adult male 05day  (32953) adult male 30day  (44832) adult female 01day  (27819) adult female 05day    7826 adult female 30day    5767 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    18 embryo 02-04hr    12 embryo 04-06hr    29 embryo 06-08hr    83 embryo 08-10hr    414 embryo 10-12hr    1003 embryo 12-14hr    643 embryo 14-16hr    231 embryo 16-18hr    187 embryo 18-20hr    2360 embryo 20-22hr    13997 embryo 22-24hr    17081 larva L1    20926 larva L2    27003 larva L3 12hr old    13834 larva L3 puffstage 1-2    4378 larva L3 puffstage 3-6    1938 larva L3 puffstage 7-9    570 white prepupae new    196 white prepupae 12hr    53 white prepupae 24hr    19 pupae 2d postWPP    17 pupae 3d postWPP    11 pupae 4d postWPP    6997 adult male 01day    37297 adult male 05day    32953 adult male 30day    44832 adult female 01day    27819 adult female 05day    7826 adult female 30day    5767 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0002570 expression level Developmental Stage   Expression Level embryo 00-02hr    18 embryo 02-04hr    12 embryo 04-06hr    29 embryo 06-08hr    83 embryo 08-10hr    414 embryo 10-12hr    1003 embryo 12-14hr    643 embryo 14-16hr    231 embryo 16-18hr    187 embryo 18-20hr    2360 embryo 20-22hr    13997 embryo 22-24hr    17081 larva L1    20926 larva L2    27003 larva L3 12hr old    13834 larva L3 puffstage 1-2    4378 larva L3 puffstage 3-6    1938 larva L3 puffstage 7-9    570 white prepupae new    196 white prepupae 12hr    53 white prepupae 24hr    19 pupae 2d postWPP    17 pupae 3d postWPP    11 pupae 4d postWPP    6997 adult male 01day    37297 adult male 05day    32953 adult male 30day    44832 adult female 01day    27819 adult female 05day    7826 adult female 30day    5767 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr    18 embryo 02-04hr    12 embryo 04-06hr    29 embryo 06-08hr    83 embryo 08-10hr  (414) embryo 10-12hr  (1003) embryo 12-14hr  (643) embryo 14-16hr  (231) embryo 16-18hr  (187) embryo 18-20hr  (2360) embryo 20-22hr  (13997) embryo 22-24hr  (17081) larva L1  (20926) larva L2  (27003) larva L3 12hr old  (13834) larva L3 puffstage 1-2  (4378) larva L3 puffstage 3-6  (1938) larva L3 puffstage 7-9  (570) white prepupae new  (196) white prepupae 12hr    53 white prepupae 24hr    19 pupae 2d postWPP    17 pupae 3d postWPP    11 pupae 4d postWPP  (6997) adult male 01day  (37297) adult male 05day  (32953) adult male 30day  (44832) adult female 01day  (27819) adult female 05day  (7826) adult female 30day  (5767) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    18 embryo 02-04hr    12 embryo 04-06hr    29 embryo 06-08hr    83 embryo 08-10hr    414 embryo 10-12hr    1003 embryo 12-14hr    643 embryo 14-16hr    231 embryo 16-18hr    187 embryo 18-20hr  2360 embryo 20-22hr  (13997) embryo 22-24hr  (17081) larva L1  (20926) larva L2  (27003) larva L3 12hr old  (13834) larva L3 puffstage 1-2  (4378) larva L3 puffstage 3-6  1938 larva L3 puffstage 7-9    570 white prepupae new    196 white prepupae 12hr    53 white prepupae 24hr    19 pupae 2d postWPP    17 pupae 3d postWPP    11 pupae 4d postWPP  (6997) adult male 01day  (37297) adult male 05day  (32953) adult male 30day  (44832) adult female 01day  (27819) adult female 05day  (7826) adult female 30day  (5767) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    18 embryo 02-04hr    12 embryo 04-06hr    29 embryo 06-08hr    83 embryo 08-10hr    414 embryo 10-12hr    1003 embryo 12-14hr    643 embryo 14-16hr    231 embryo 16-18hr    187 embryo 18-20hr    2360 embryo 20-22hr  13997 embryo 22-24hr  17081 larva L1  (20926) larva L2  (27003) larva L3 12hr old  13834 larva L3 puffstage 1-2    4378 larva L3 puffstage 3-6    1938 larva L3 puffstage 7-9    570 white prepupae new    196 white prepupae 12hr    53 white prepupae 24hr    19 pupae 2d postWPP    17 pupae 3d postWPP    11 pupae 4d postWPP    6997 adult male 01day  (37297) adult male 05day  (32953) adult male 30day  (44832) adult female 01day  (27819) adult female 05day    7826 adult female 30day    5767 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    18 embryo 02-04hr    12 embryo 04-06hr    29 embryo 06-08hr    83 embryo 08-10hr    414 embryo 10-12hr    1003 embryo 12-14hr    643 embryo 14-16hr    231 embryo 16-18hr    187 embryo 18-20hr    2360 embryo 20-22hr    13997 embryo 22-24hr    17081 larva L1    20926 larva L2    27003 larva L3 12hr old    13834 larva L3 puffstage 1-2    4378 larva L3 puffstage 3-6    1938 larva L3 puffstage 7-9    570 white prepupae new    196 white prepupae 12hr    53 white prepupae 24hr    19 pupae 2d postWPP    17 pupae 3d postWPP    11 pupae 4d postWPP    6997 adult male 01day    37297 adult male 05day    32953 adult male 30day    44832 adult female 01day    27819 adult female 05day    7826 adult female 30day    5767 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0002570    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0002570 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: larval/adult midgut. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0002570 expression level Tissue   Expression Level Larval Central Nervous System    0.575 Larval Midgut    1611.9 Larval Hindgut    5.9 Larval Malpighian Tubules    4 Larval Fat Body    1.9 Larval Salivary Gland    0.7 Larval Trachea    1.55 Larval Carcass    0.95 Adult Head    35 Adult Eye no informative data Adult Brain    1.7 Adult Thoracic-Abdominal Ganglion    1.7 Adult Crop    6.4 Adult Midgut    6005.6 Adult Hindgut no informative data Adult Malpighian Tubules    5.1 Adult Fat Body    1.9 Adult Salivary Gland    2.5 Adult Heart    2.85 Adult VirginFemale Spermatheca    1 Adult InseminatedFemale Spermatheca    1.6 Adult Ovary    2 Adult Testis no informative data Adult Male Accessory Gland    2.8 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    0.575 Larval Midgut  (1611.9) Larval Hindgut    5.9 Larval Malpighian Tubules    4 Larval Fat Body    1.9 Larval Salivary Gland    0.7 Larval Trachea    1.55 Larval Carcass    0.95 Adult Head    35 Adult Eye no informative data Adult Brain    1.7 Adult Thoracic-Abdominal Ganglion    1.7 Adult Crop    6.4 Adult Midgut  (6005.6) Adult Hindgut no informative data Adult Malpighian Tubules    5.1 Adult Fat Body    1.9 Adult Salivary Gland    2.5 Adult Heart    2.85 Adult VirginFemale Spermatheca    1 Adult InseminatedFemale Spermatheca    1.6 Adult Ovary    2 Adult Testis no informative data Adult Male Accessory Gland    2.8 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    0.575 Larval Midgut  (1611.9) Larval Hindgut    5.9 Larval Malpighian Tubules    4 Larval Fat Body    1.9 Larval Salivary Gland    0.7 Larval Trachea    1.55 Larval Carcass    0.95 Adult Head    35 Adult Eye no informative data Adult Brain    1.7 Adult Thoracic-Abdominal Ganglion    1.7 Adult Crop    6.4 Adult Midgut  (6005.6) Adult Hindgut no informative data Adult Malpighian Tubules    5.1 Adult Fat Body    1.9 Adult Salivary Gland    2.5 Adult Heart    2.85 Adult VirginFemale Spermatheca    1 Adult InseminatedFemale Spermatheca    1.6 Adult Ovary    2 Adult Testis no informative data Adult Male Accessory Gland    2.8 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    0.575 Larval Midgut    1611.9 Larval Hindgut    5.9 Larval Malpighian Tubules    4 Larval Fat Body    1.9 Larval Salivary Gland    0.7 Larval Trachea    1.55 Larval Carcass    0.95 Adult Head    35 Adult Eye no informative data Adult Brain    1.7 Adult Thoracic-Abdominal Ganglion    1.7 Adult Crop    6.4 Adult Midgut    6005.6 Adult Hindgut no informative data Adult Malpighian Tubules    5.1 Adult Fat Body    1.9 Adult Salivary Gland    2.5 Adult Heart    2.85 Adult VirginFemale Spermatheca    1 Adult InseminatedFemale Spermatheca    1.6 Adult Ovary    2 Adult Testis no informative data Adult Male Accessory Gland    2.8 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0002570 expression level Tissue   Expression Level Larval Central Nervous System    0.575 Larval Midgut    1611.9 Larval Hindgut    5.9 Larval Malpighian Tubules    4 Larval Fat Body    1.9 Larval Salivary Gland    0.7 Larval Trachea    1.55 Larval Carcass    0.95 Adult Head    35 Adult Eye no informative data Adult Brain    1.7 Adult Thoracic-Abdominal Ganglion    1.7 Adult Crop    6.4 Adult Midgut    6005.6 Adult Hindgut no informative data Adult Malpighian Tubules    5.1 Adult Fat Body    1.9 Adult Salivary Gland    2.5 Adult Heart    2.85 Adult VirginFemale Spermatheca    1 Adult InseminatedFemale Spermatheca    1.6 Adult Ovary    2 Adult Testis no informative data Adult Male Accessory Gland    2.8 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    0.575 Larval Midgut  (1611.9) Larval Hindgut    5.9 Larval Malpighian Tubules    4 Larval Fat Body    1.9 Larval Salivary Gland    0.7 Larval Trachea    1.55 Larval Carcass    0.95 Adult Head    35 Adult Eye no informative data Adult Brain    1.7 Adult Thoracic-Abdominal Ganglion    1.7 Adult Crop    6.4 Adult Midgut  (6005.6) Adult Hindgut no informative data Adult Malpighian Tubules    5.1 Adult Fat Body    1.9 Adult Salivary Gland    2.5 Adult Heart    2.85 Adult VirginFemale Spermatheca    1 Adult InseminatedFemale Spermatheca    1.6 Adult Ovary    2 Adult Testis no informative data Adult Male Accessory Gland    2.8 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    0.575 Larval Midgut  1611.9 Larval Hindgut    5.9 Larval Malpighian Tubules    4 Larval Fat Body    1.9 Larval Salivary Gland    0.7 Larval Trachea    1.55 Larval Carcass    0.95 Adult Head    35 Adult Eye no informative data Adult Brain    1.7 Adult Thoracic-Abdominal Ganglion    1.7 Adult Crop    6.4 Adult Midgut  (6005.6) Adult Hindgut no informative data Adult Malpighian Tubules    5.1 Adult Fat Body    1.9 Adult Salivary Gland    2.5 Adult Heart    2.85 Adult VirginFemale Spermatheca    1 Adult InseminatedFemale Spermatheca    1.6 Adult Ovary    2 Adult Testis no informative data Adult Male Accessory Gland    2.8 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    0.575 Larval Midgut    1611.9 Larval Hindgut    5.9 Larval Malpighian Tubules    4 Larval Fat Body    1.9 Larval Salivary Gland    0.7 Larval Trachea    1.55 Larval Carcass    0.95 Adult Head    35 Adult Eye no informative data Adult Brain    1.7 Adult Thoracic-Abdominal Ganglion    1.7 Adult Crop    6.4 Adult Midgut    6005.6 Adult Hindgut no informative data Adult Malpighian Tubules    5.1 Adult Fat Body    1.9 Adult Salivary Gland    2.5 Adult Heart    2.85 Adult VirginFemale Spermatheca    1 Adult InseminatedFemale Spermatheca    1.6 Adult Ovary    2 Adult Testis no informative data Adult Male Accessory Gland    2.8 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye no informative data Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut no informative data Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis no informative data Adult Male Accessory Gland     Adult Carcass no informative data FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    35   NA  Eye    no informative data   NA  Brain    1.7   0.575  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    1.7   NA  Crop    6.4   1611.9  Midgut    6005.6   5.9  Hindgut    no informative data   4  Malpighian Tubules    5.1   1.9  Fat Body    1.9   0.7  Salivary Gland    2.5   NA  Heart    2.85   1.55  Trachea    NA   NA  VirginFemale Spermatheca    1   NA  InseminatedFemale Spermatheca    1.6   NA  Ovary    2   NA  Testis    no informative data   NA  Male Accessory Gland    2.8   0.95  Carcass    no informative data modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_20
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0002570 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG8696-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele viable, with Scer\GAL4pnr-MD237 Mal-A1GD5459 Phenotype manifest in Allele
Classical Alleles ( 1 )
For All Classical Alleles Show
Allele of Mal-A1 Class Mutagen Stocks Known lesion Mal-A1MB05107 1 --
Alleles Carried on Transgenic Constructs ( 2 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Mal-A1 Class Mutagen Stocks Known lesion Mal-A1GD5459 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes Mal-A1KK105272 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes
Aneuploid Aberrations
Disrupted in	Df(2R)Exel7096 (Ryder, 2004.4.26)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data
Insertions
	Type of insertions Name Expression data insertion of enhancer trap binary system Mi{ET1}Mal-A1MB05107 No
Gene Ontology: Function, Process & Cellular Component ( 5 unique terms )
Terms Based on Experimental Evidence ( 0 terms )
Terms Based on Predictions or Assertions ( 5 terms )
Molecular Function
CV term Evidence References
alpha-glucosidase activity non-traceable author statement (Swiss-Prot Project Members, 1988.4.1) catalytic activity inferred from electronic annotation with InterPro:IPR006047, InterPro:IPR006589, InterPro:IPR013780, InterPro:IPR013781 (FlyBase Curators et al., 2004-) cation binding inferred from electronic annotation with InterPro:IPR006047, InterPro:IPR006589, InterPro:IPR013780, InterPro:IPR013781 (FlyBase Curators et al., 2004-)
Biological Process
CV term Evidence References
carbohydrate metabolic process inferred from electronic annotation with InterPro:IPR006047, InterPro:IPR006589, InterPro:IPR013780, InterPro:IPR013781 (FlyBase Curators et al., 2004-) glucose metabolic process non-traceable author statement (Swiss-Prot Project Members, 1988.4.1)
Cellular Component ( 0 terms)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Mal-A1 allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 61676 DroID - A comprehensive database of gene and protein interactions. • FBgn0002570 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 35824
Orthologs
Genome-wide drosophilid orthologs	Dana\Mal-A1 Dere\Mal-A1 Dgri\Mal-A1 Dmoj\Mal-A1 Dper\Mal-A1 Dpse\Mal-A1 Dsec\Mal-A1 Dsim\Mal-A1 Dvir\Mal-A1 Dwil\Mal-A1 Dyak\Mal-A1
Curated drosophilid orthologs	Dpse\GA21265
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AGAP002102-PA Anopheles gambiae (mosquito) BGIBMGA003057-PA Bombyx mori (silk worm) ENSCAFP00000003699 Canis familiaris (dog) XP_001604662.1 Nasonia vitripennis (wasp) ENSOANP00000019461 Ornithorynchus anatinus (platypus) Smp_037540.2 Schistosoma mansoni (trematode parasite) Smp_052510 Schistosoma mansoni (trematode parasite) Smp_156550 Schistosoma mansoni (trematode parasite) 82181.m00192 Trichomonas vaginalis (parasitic flagellated protozoan) 84076.m00034 Trichomonas vaginalis (parasitic flagellated protozoan) 89334.m00072 Trichomonas vaginalis (parasitic flagellated protozoan) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB12189 NV12204 NV12203 NV11134 NV11133 LH24003 LH24002 LH19162 FBgn0240205 FBgn0235956 FBgn0223797 FBgn0217169 FBgn0207770 FBgn0022838 FBgn0195164 FBgn0181944 FBgn0181477 FBgn0175567 JGI_V11_314822 FBgn0245904 FBgn0073399 FBgn0152976 FBgn0148471 FBgn0147438 FBgn0143635 FBgn0032382 FBgn0128275 FBgn0121288 FBgn0115882 FBgn0102948 FBgn0098607 FBgn0089623 CPIJ013171 CPIJ013169 CPIJ013170 CPIJ005213 BGIBMGA003057 ACYPI000768 GB19017 GB12607 AGAP008965 AAEL010536 AAEL010532 PB24189 GLEAN_08359 GLEAN_08358 GLEAN_08357
Stocks & Reagents
Stocks Listed in FlyBase ( 4 )
Bloomington	24850 w1118; Mi{ET1}Mal-A1MB05107
VDRC	v106220 P{KK105272}VIE-260B v15789 w1118; P{GD5459}v15789 v15790 w1118; P{GD5459}v15790/TM3
Genomic Clones ( 1 )
	BACR34O23 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 47 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	RE72980
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	GH16695 GH27641 HL03582 LP09544 RE16233 RE26576 RE51942 RE59173
Other clones	56557 72801 74883 214379.34 CK01.65A.F7 Dmel_dig_004276_0711_1259 Dmel_dig_006811_0692_2245 Dmel_dig_014651_0644_0825 Dmel_dig_018916_0619_0840 Dmel_neb_005605_0908_3325 Dmel_neb_008778_0697_0930 Dmel_neb_011699_0899_3014 Dmel_neb_013279_0127_1564 Dmel_neb_014417_0861_2831 Dmel_neb_014797_0633_0586 Dmel_neb_014807_0827_1977 Dmel_neb_014886_0113_1996 Dmel_neb_015214_0680_2789 Dmel_neb_015952_0436_3568 EC38653 EK053024 EK169217 EK201616 EK207139 EP09928 RP003042166 RP003114216 RP003158277 RP003170416 RP003202507 RP003268200 RP003322640 RP003331233 RP003470916 RP003530895 RP003569007 RP003581723 RP003652710
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0002570 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 35824
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: Mal-A1 LvpH (Gabrisko and Janecek, 2011)
Source for database merge of
Additional comments
Other Comments
	Identified during a molecular analysis of the larval cuticle proteins Lcp1, Lcp2, Lcp3 and Lcp4 at 44D. (Snyder et al., 1982) One of three genes that are clustered in an 8 kb segment of DNA and lie 11 kb from the second-chromosome Lcp gene cluster (Snyder and Davidson, 1983). The order of the genes is LvpH--1.7kb--LvpD--1.1kb--LvpL, with LvpH being closest to the Lcp cluster. LvpH and LvpL are transcribed off the same strand as Lcp1 and Lcp2 and LcpD off the same strand as Lcp3 and Lcp4. Three genes are completely sequenced and are 50-60% homologous in DNA sequence; they encode polypeptides of approximately 500 amino acids, which contain apparent signal peptide sequences but lack hydrophobic regions indicating that they are secreted rather than being membrane proteins; each has a sequence of 12 amino acids similar to known calcium binding domains of other proteins. The genes are coordinately transcribed in abundance in young larvae and adults, but not in late larvae when Lcp genes are transcribed; whereas Lcp genes are transcribed in the larval cuticle, Lvp transcripts are found in the larval viscera. The time and place of Lvp transcription suggests a possible digestive function of the gene products.
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_057279 RefSeq (Proteins) • NP_476627 DDBJ / EMBL / GenBank • AAF59089 AC005451 CAA23491 V00204 Entrez Gene - A searchable database of RefSeq genes. • 35824 UniProtKB/Swiss-Prot • P07190
Other Crossreferences
	EPD - Eukarytoic Promoter Database, an annotated collection of POL II promoters • 07033 07034 InterPro domains - A database of protein families, domains, and functional sites • Glycosyl hydrolase, family 13, catalytic domain (IPR006047) Glycosyl hydrolase, family 13, subfamily, catalytic domain (IPR006589) Glycoside hydrolase, subgroup, catalytic domain (IPR013781) Glycoside hydrolase, superfamily (IPR017853) Alpha amylase (IPR015902) Glycosyl hydrolase, family 13, all-beta (IPR013780)
Linkouts
	BioGRID - A database of protein and genetic interactions • 61676 DroID - A comprehensive database of gene and protein interactions. • FBgn0002570 DRSC - Results from RNAi screens. • FBgn0002570 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0002570 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG8696-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0002570 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 35824 InParanoid A subset of ortholog calls from InParanoid. • AGAP002102-PA Anopheles gambiae (mosquito) BGIBMGA003057-PA Bombyx mori (silk worm) ENSCAFP00000003699 Canis familiaris (dog) XP_001604662.1 Nasonia vitripennis (wasp) ENSOANP00000019461 Ornithorynchus anatinus (platypus) Smp_037540.2 Schistosoma mansoni (trematode parasite) Smp_052510 Schistosoma mansoni (trematode parasite) Smp_156550 Schistosoma mansoni (trematode parasite) 82181.m00192 Trichomonas vaginalis (parasitic flagellated protozoan) 84076.m00034 Trichomonas vaginalis (parasitic flagellated protozoan) 89334.m00072 Trichomonas vaginalis (parasitic flagellated protozoan) InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 35824 modMine - Data generated by the modENCODE project. • FBgn0002570 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB12189 NV12204 NV12203 NV11134 NV11133 LH24003 LH24002 LH19162 FBgn0240205 FBgn0235956 FBgn0223797 FBgn0217169 FBgn0207770 FBgn0022838 FBgn0195164 FBgn0181944 FBgn0181477 FBgn0175567 JGI_V11_314822 FBgn0245904 FBgn0073399 FBgn0152976 FBgn0148471 FBgn0147438 FBgn0143635 FBgn0032382 FBgn0128275 FBgn0121288 FBgn0115882 FBgn0102948 FBgn0098607 FBgn0089623 CPIJ013171 CPIJ013169 CPIJ013170 CPIJ005213 BGIBMGA003057 ACYPI000768 GB19017 GB12607 AGAP008965 AAEL010536 AAEL010532 PB24189 GLEAN_08359 GLEAN_08358 GLEAN_08357
Synonyms & Secondary IDs ( 14 )
Reported As
Symbol Synonym	CG8696 (Fulton et al., 2001, Keleman et al., 2009.8.5) Drome_A1 (Gabriško and Janeček, 2011) H (Vieira et al., 1997, Henikoff and Wallace, 1988) LvpH (Gabrisko and Janecek, 2011, Geng and MacDonald, 2007) lvpH (Gabriško and Janeček, 2011) mal_A1 (Gabrisko and Janecek, 2011, Gabriško and Janeček, 2011) Mal-A1   V (Snyder et al., 1982)
Name Synonym	gene V (Snyder et al., 1982) hdl cuticle gene cluster (Snyder, 1993.3.25) Larval visceral protein H   maltase (Vieira et al., 1997) Maltase A1   maltase H precursor (Prager et al., 2007)
Secondary FlyBase IDs
References ( 30 )
Generate a list of	All references relating to this gene ( 30 )
List References by type	Research paper  ( 12 ) Supplementary material  ( 4 ) Personal communication to FlyBase  ( 5 ) FlyBase analysis  ( 2 ) DNA/RNA sequence record  ( 1 ) Protein sequence record  ( 1 ) Computer file  ( 2 ) Automatic genome annotation  ( 1 ) Book  ( 1 ) Curated genome annotation  ( 1 )
Recent research papers ( 2 )
	Baycin-Hizal et al., 2011, J. Proteome Res. 10(6): 2777--2784 GlycoFly: A Database of Drosophila N-linked Glycoproteins Identified Using SPEG-MS Techniques. [FBrf0213834] Gabriško and Janeček, 2011, J. Mol. Evol. 72(1): 104--118 Characterization of maltase clusters in the genus Drosophila. [FBrf0212941] Show all research papers ...