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Gene Dmel\sens

General Information
Symbol	Dmel\sens	Species	D. melanogaster
Name	senseless	Annotation symbol	CG32120
Feature type	protein_coding_gene	FlyBase ID	FBgn0002573
Gene Model Status	Current	Stock availability	46 publicly available
Also Known As	Ly, Sen, sense
Genomic Location
Chromosome (arm)	3L	Recombination map	3-40.5
Cytogenetic map	70A8-70A8	Sequence location	3L:13,389,328..13,394,225 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene senseless is referred to in FlyBase by the symbol Dmel\sens (CG32120, FBgn0002573). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: bHLH transcription factor binding; sequence-specific DNA binding; RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription; RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity. There is experimental evidence for 12 unique biological process terms, many of which group under: single-organism developmental process; sensory organ development; neuron differentiation; cellular component organization or biogenesis; system development; biological regulation; compound eye photoreceptor development; negative regulation of cellular biosynthetic process; regulation of apoptotic process; neuron projection development. 45 alleles are reported. The phenotypes of these alleles are annotated with: organ system subdivision; adult segment; organ system; external compound sense organ; peripheral nervous system; thoracic segment; non-connected developing system; eo support cell; late extended germ band embryo; extended germ band embryo. It has one annotated transcript and one annotated polypeptide. Protein features are: Zinc finger C2H2-type/integrase DNA-binding domain; Zinc finger, C2H2; Zinc finger, C2H2-like; Zinc finger, CCHC-type. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of very low expression. Peak expression observed within 06-12 hour embryonic stages. Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: larval/adult salivary gland. Comments on Affy2 ProbeSet: ProbeSet 1632294_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of sens. Gene sequence location is 3L:13389328..13394225.
User Contributed Data
	Beta version, feedback welcome
External Summaries
Phenotypic Description from the Red Book (Lindsley & Zimm 1992)
Gene/Allele symbols may differ from current usage	Ly: Lyra Ly: Lyra From Bridges and Brehme, 1944, Carnegie Inst. Washington Publ. No. 552: 118. Lateral margins of wings excised, giving narrowed shape; angle between veins L2 and L5 reduced. Bristles shortened and stubby; postscutellars frequently missing. Eyes somewhat deformed with tufted vibrissae. Abdomen dark and narrow with rear edge of tergites raised. Homozygous lethal. Ly/Df(3L)M69E is lethal. Modification of wings first visible as marginal scalloping of prepupal wing buds; wing fold narrower (Waddington, 1939, Proc. Nat. Acad. Sci. USA 25: 304; 1940, J. Genet. 41: 75-139). RK1A.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 70A8-70A8   Limits computationally determined from genome sequence between P{PZ}l(3)0422004220&P{lacW}l(3)j10B6j10B6 and P{PZ}stv00543
Experimentally Determined Cytological Location
Cytogenetic map Notes References 70A-70A     (Nolo, 1999.12.6)
Experimentally Determined Recombination Data
Location	3-41 (Nolo et al., 2000) 3-40.5   3- (Deak et al., 1997)
Left of (cM)
Right of (cM)
Notes	Maps by recombination either to 3-23 or 3-41.7. The precise mapping position could not be determined because of chromosomal rearrangements. (Salzberg et al., 1994) On 3L. (Deak et al., 1997)
Gene Model & Products
Please see the GBrowse view of Dmel\sens for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.46 Low-frequency RNA-Seq exon junction(s) not annotated.
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) sens-RA FBtr0075862  NM_080079   2451   541
Additional Transcript Data & Comments
Reported size (kB)	2.8 (northern blot) (Nolo et al., 2000)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein sens-PA   FBpp0075596   61.3   541   8.60     NP_524818   AAN11834
Additional Polypeptide Data & Comments
Reported size (kDa)	541 (aa) (Nolo et al., 2000)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Zinc finger C2H2-type/integrase DNA-binding domain (IPR013087) Zinc finger, C2H2-like (IPR015880) Zinc finger, C2H2 (IPR007087) Zinc finger, CCHC-type (IPR001878)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AE014296 AAN11834   AF212312 AAF32280   AF212313 AAF32281   BE662095   BT022164   BT023706   CO265205   CZ488832   EC221717
UniProtKB/Swiss-Prot	Q9N658
UniProtKB/TrEMBL
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References regulatory region FBsf0000435556 3L:13,395,416..13,396,396 evidence=Reporter construct (in vivo) (Rouault et al., 2010, Halfon, 2012.6.19)
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage 9 -- 10   antennal primordium   (Fisher et al., 2012) clypeo-labral primordium   (Fisher et al., 2012) dorsal ectoderm   (Fisher et al., 2012) embryonic stage 10   lateral ectoderm | restricted   (Nolo et al., 2000) embryonic stage 10 -- 12   presumptive embryonic/larval peripheral nervous system | restricted   (Nolo et al., 2000) sensory mother cell   (Nolo et al., 2000) embryonic stage 10 -- 17   external sensory organ precursor cell   (Tsuda et al., 2005) embryonic stage 11 -- 12   external sensory organ precursor cell IIa   (Nolo et al., 2000) external sensory organ precursor cell I   (Nolo et al., 2000) external sensory organ precursor cell IIb   (Nolo et al., 2000) antennal primordium   (Fisher et al., 2012) Bolwig organ primordium   (Fisher et al., 2012) Comment:reported as larval eye primordium dorsal sensory complex primordium   (Fisher et al., 2012) hypopharyngeal sense organ primordium   (Fisher et al., 2012) labial sensory complex primordium   (Fisher et al., 2012) labral sensory complex primordium   (Fisher et al., 2012) maxillary sensory complex primordium   (Fisher et al., 2012) salivary gland body primordium   (Fisher et al., 2012) Comment:reported as salivary gland primordium ventral sensory complex anlage   (Fisher et al., 2012) embryonic stage 11 -- 13   salivary gland   (Nolo et al., 2000) embryonic stage 11 -- 17   adult salivary gland primordium   (Chandrasekaran and Beckendorf, 2003) embryonic stage 13 -- 16   Bolwig organ   (Fisher et al., 2012) dorsal sensory complex proper primordium   (Fisher et al., 2012) Comment:reported as dorsal/lateral sensory complexes embryonic antennal sense organ   (Fisher et al., 2012) embryonic labial sensory complex   (Fisher et al., 2012) embryonic maxillary sensory complex   (Fisher et al., 2012) embryonic/larval salivary gland   (Fisher et al., 2012) hypopharyngeal sense organ   (Fisher et al., 2012) labral sensory complex   (Fisher et al., 2012) ventral sensory complex primordium   (Fisher et al., 2012)
Additional Descriptive Data
	sens transcript is expressed in sensory organ precursors. Expression is first detected in stage 10 embryos in 2-4 cell ectodermal clusters. Expression quickly refines to the ectodermal cells giving rise to a subset of SOP cells. During stage 11, expression accumulates in SOPI and SOPII cells, with high expression in SOPI cells and low expression in the progeny of SOPII cells. sens mRNA disappears during germ band retraction, and by stage 13, expression is only detected in the salivary glands. (Nolo et al., 2000)
Marker for
	external sensory organ precursor cell
Subcellular Localization
CV Term
Polypeptide Expression
distribution deduced from reporter Stage Tissue/Position (including subcellular localization) Reference third instar larval stage   eye disc | restricted   (Fu and Baker, 2003) immunolocalization Stage Tissue/Position (including subcellular localization) Reference embryonic stage 10 -- 14   presumptive embryonic/larval peripheral nervous system | restricted   (Nolo et al., 2000) sensory mother cell   (Nolo et al., 2000) embryonic stage 11   sensory organ cell   (Orgogozo et al., 2004) embryonic stage 11 -- 14   salivary gland   (Nolo et al., 2000) embryonic stage 11 -- 17   adult salivary gland primordium   (Chandrasekaran and Beckendorf, 2003) third instar larval stage   metathoracic femoral chordotonal organ   (Nolo et al., 2000) mesothoracic femoral chordotonal organ   (Nolo et al., 2000) eye-antennal disc | restricted   (Nolo et al., 2000) wing disc | restricted   (Nolo et al., 2000) Johnston organ   (Nolo et al., 2000) photoreceptor cell R8   (Nolo et al., 2000, Fu and Baker, 2003) sensory mother cell   (Nolo et al., 2000) prothoracic femoral chordotonal organ   (Nolo et al., 2000) photoreceptor cell R8   • nucleus (Tomasi et al., 2008) third instar larval stage -- adult stage   photoreceptor cell R7 | subset   (Domingos et al., 2004) adult stage   photoreceptor cell R8   (Wernet et al., 2003) Comment:not in dorsal margin photoreceptor R8
Additional Descriptive Data
	sens is a nuclear protein whose expression is limited to precursors and early differentiating cells of the PNS. sens protein and transcript expression patterns are similar. Expression is mainly detected in proneural fields of some SOPs, nuclei of SOPs, and differentiating cells of the PNS. sens protein is first detected at stage 10, peaks at stages 11 and 12, and starts disappearing by stage 13. Expression was also studied in imaginal discs. sens protein is expressed in eye-antennal discs in the R8 photoreceptors, two clusters of cells in the lateral portion of the disc, and the chordotonal organs of Johnston organs. In leg discs, expression is detected in the femoral chordotonal organ, and other external sensory SOPs. In wing discs, sens expression is dynamic, with expression first detected in ectodermal cells surrounding presumptive SOPs. The presumptive SOPs subsequently accumulate higher levels of sens protein. Comparison of sens and Dhyd\E(spl) protein expression in wild-type discs indicates that the expression of the two proteins do not overlap significantly. (Nolo et al., 2000)
Marker for
	sensory organ cell photoreceptor cell R7 photoreceptor cell R8
Subcellular Localization (GO Cellular Component)
CV term Evidence References
nucleus inferred from direct assay (Tomasi et al., 2008, Li-Kroeger et al., 2008)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: larval/adult salivary gland. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    2.525 Larval Midgut    3.8 Larval Hindgut    3.7 Larval Malpighian Tubules    2.5 Larval Fat Body    11.7 Larval Salivary Gland    1089.4 Larval Trachea    18.25 Larval Carcass    1.225 Adult Head    5.7 Adult Eye    25.05 Adult Brain    1.6 Adult Thoracic-Abdominal Ganglion    2.7 Adult Crop    16.6 Adult Midgut    3.4 Adult Hindgut    1.3 Adult Malpighian Tubules    1.9 Adult Fat Body    5.2 Adult Salivary Gland    1184.7 Adult Heart    1.1 Adult VirginFemale Spermatheca    3.7 Adult InseminatedFemale Spermatheca    2 Adult Ovary    1.6 Adult Testis    53.8 Adult Male Accessory Gland    5.7 Adult Carcass    4.4 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    2.525 Larval Midgut    3.8 Larval Hindgut    3.7 Larval Malpighian Tubules    2.5 Larval Fat Body    11.7 Larval Salivary Gland  (1089.4) Larval Trachea    18.25 Larval Carcass    1.225 Adult Head    5.7 Adult Eye    25.05 Adult Brain    1.6 Adult Thoracic-Abdominal Ganglion    2.7 Adult Crop    16.6 Adult Midgut    3.4 Adult Hindgut    1.3 Adult Malpighian Tubules    1.9 Adult Fat Body    5.2 Adult Salivary Gland  (1184.7) Adult Heart    1.1 Adult VirginFemale Spermatheca    3.7 Adult InseminatedFemale Spermatheca    2 Adult Ovary    1.6 Adult Testis    53.8 Adult Male Accessory Gland    5.7 Adult Carcass    4.4 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    2.525 Larval Midgut    3.8 Larval Hindgut    3.7 Larval Malpighian Tubules    2.5 Larval Fat Body    11.7 Larval Salivary Gland  (1089.4) Larval Trachea    18.25 Larval Carcass    1.225 Adult Head    5.7 Adult Eye    25.05 Adult Brain    1.6 Adult Thoracic-Abdominal Ganglion    2.7 Adult Crop    16.6 Adult Midgut    3.4 Adult Hindgut    1.3 Adult Malpighian Tubules    1.9 Adult Fat Body    5.2 Adult Salivary Gland  (1184.7) Adult Heart    1.1 Adult VirginFemale Spermatheca    3.7 Adult InseminatedFemale Spermatheca    2 Adult Ovary    1.6 Adult Testis    53.8 Adult Male Accessory Gland    5.7 Adult Carcass    4.4 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    2.525 Larval Midgut    3.8 Larval Hindgut    3.7 Larval Malpighian Tubules    2.5 Larval Fat Body    11.7 Larval Salivary Gland    1089.4 Larval Trachea    18.25 Larval Carcass    1.225 Adult Head    5.7 Adult Eye    25.05 Adult Brain    1.6 Adult Thoracic-Abdominal Ganglion    2.7 Adult Crop    16.6 Adult Midgut    3.4 Adult Hindgut    1.3 Adult Malpighian Tubules    1.9 Adult Fat Body    5.2 Adult Salivary Gland    1184.7 Adult Heart    1.1 Adult VirginFemale Spermatheca    3.7 Adult InseminatedFemale Spermatheca    2 Adult Ovary    1.6 Adult Testis    53.8 Adult Male Accessory Gland    5.7 Adult Carcass    4.4 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    2.525 Larval Midgut    3.8 Larval Hindgut    3.7 Larval Malpighian Tubules    2.5 Larval Fat Body    11.7 Larval Salivary Gland    1089.4 Larval Trachea    18.25 Larval Carcass    1.225 Adult Head    5.7 Adult Eye    25.05 Adult Brain    1.6 Adult Thoracic-Abdominal Ganglion    2.7 Adult Crop    16.6 Adult Midgut    3.4 Adult Hindgut    1.3 Adult Malpighian Tubules    1.9 Adult Fat Body    5.2 Adult Salivary Gland    1184.7 Adult Heart    1.1 Adult VirginFemale Spermatheca    3.7 Adult InseminatedFemale Spermatheca    2 Adult Ovary    1.6 Adult Testis    53.8 Adult Male Accessory Gland    5.7 Adult Carcass    4.4 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    2.525 Larval Midgut    3.8 Larval Hindgut    3.7 Larval Malpighian Tubules    2.5 Larval Fat Body    11.7 Larval Salivary Gland  (1089.4) Larval Trachea    18.25 Larval Carcass    1.225 Adult Head    5.7 Adult Eye    25.05 Adult Brain    1.6 Adult Thoracic-Abdominal Ganglion    2.7 Adult Crop    16.6 Adult Midgut    3.4 Adult Hindgut    1.3 Adult Malpighian Tubules    1.9 Adult Fat Body    5.2 Adult Salivary Gland  (1184.7) Adult Heart    1.1 Adult VirginFemale Spermatheca    3.7 Adult InseminatedFemale Spermatheca    2 Adult Ovary    1.6 Adult Testis    53.8 Adult Male Accessory Gland    5.7 Adult Carcass    4.4 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    2.525 Larval Midgut    3.8 Larval Hindgut    3.7 Larval Malpighian Tubules    2.5 Larval Fat Body    11.7 Larval Salivary Gland  1089.4 Larval Trachea    18.25 Larval Carcass    1.225 Adult Head    5.7 Adult Eye    25.05 Adult Brain    1.6 Adult Thoracic-Abdominal Ganglion    2.7 Adult Crop    16.6 Adult Midgut    3.4 Adult Hindgut    1.3 Adult Malpighian Tubules    1.9 Adult Fat Body    5.2 Adult Salivary Gland  1184.7 Adult Heart    1.1 Adult VirginFemale Spermatheca    3.7 Adult InseminatedFemale Spermatheca    2 Adult Ovary    1.6 Adult Testis    53.8 Adult Male Accessory Gland    5.7 Adult Carcass    4.4 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    2.525 Larval Midgut    3.8 Larval Hindgut    3.7 Larval Malpighian Tubules    2.5 Larval Fat Body    11.7 Larval Salivary Gland    1089.4 Larval Trachea    18.25 Larval Carcass    1.225 Adult Head    5.7 Adult Eye    25.05 Adult Brain    1.6 Adult Thoracic-Abdominal Ganglion    2.7 Adult Crop    16.6 Adult Midgut    3.4 Adult Hindgut    1.3 Adult Malpighian Tubules    1.9 Adult Fat Body    5.2 Adult Salivary Gland    1184.7 Adult Heart    1.1 Adult VirginFemale Spermatheca    3.7 Adult InseminatedFemale Spermatheca    2 Adult Ovary    1.6 Adult Testis    53.8 Adult Male Accessory Gland    5.7 Adult Carcass    4.4 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    5.7   NA  Eye    25.05   NA  Brain    1.6   2.525  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    2.7   NA  Crop    no informative data   3.8  Midgut    3.4   3.7  Hindgut    1.3   2.5  Malpighian Tubules    1.9   no informative data  Fat Body    5.2   1089.4  Salivary Gland    1184.7   NA  Heart    1.1   no informative data  Trachea    NA   NA  VirginFemale Spermatheca    3.7   NA  InseminatedFemale Spermatheca    2   NA  Ovary    1.6   NA  Testis    53.8   NA  Male Accessory Gland    5.7   1.225  Carcass    4.4 FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    6 central nervous system, larvae L3    1 central nervous system, pupae P8    0 head, virgin 1-day female    0 head, virgin 4-day female    0 head, virgin 20-day female    0 head, mated 1-day female    1 head, mated 4-day female    0 head, mated 20-day female    0 head, mated 1-day male    0 head, mated 4-day male    0 head, mated 20-day male    0 salivary gland, larvae L3 wandering    14 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    0 digestive system, 4-day adult    1 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    1 fat body, pupae P8    0 carcass, larvae L3 wandering    4 carcass, 1-day adult    1 carcass, 4-day adult    1 carcass, 20-day adult    1 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    2 accessory gland, mated 4-day male    0 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    6 central nervous system, larvae L3    1 central nervous system, pupae P8    0 head, virgin 1-day female    0 head, virgin 4-day female    0 head, virgin 20-day female    0 head, mated 1-day female    1 head, mated 4-day female    0 head, mated 20-day female    0 head, mated 1-day male    0 head, mated 4-day male    0 head, mated 20-day male    0 salivary gland, larvae L3 wandering    14 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    0 digestive system, 4-day adult    1 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    1 fat body, pupae P8    0 carcass, larvae L3 wandering    4 carcass, 1-day adult    1 carcass, 4-day adult    1 carcass, 20-day adult    1 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    2 accessory gland, mated 4-day male    0 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    6 central nervous system, larvae L3    1 central nervous system, pupae P8    0 head, virgin 1-day female    0 head, virgin 4-day female    0 head, virgin 20-day female    0 head, mated 1-day female    1 head, mated 4-day female    0 head, mated 20-day female    0 head, mated 1-day male    0 head, mated 4-day male    0 head, mated 20-day male    0 salivary gland, larvae L3 wandering    14 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    0 digestive system, 4-day adult    1 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    1 fat body, pupae P8    0 carcass, larvae L3 wandering    4 carcass, 1-day adult    1 carcass, 4-day adult    1 carcass, 20-day adult    1 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    2 accessory gland, mated 4-day male    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    6 central nervous system, larvae L3    1 central nervous system, pupae P8    0 head, virgin 1-day female    0 head, virgin 4-day female    0 head, virgin 20-day female    0 head, mated 1-day female    1 head, mated 4-day female    0 head, mated 20-day female    0 head, mated 1-day male    0 head, mated 4-day male    0 head, mated 20-day male    0 salivary gland, larvae L3 wandering    14 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    0 digestive system, 4-day adult    1 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    1 fat body, pupae P8    0 carcass, larvae L3 wandering    4 carcass, 1-day adult    1 carcass, 4-day adult    1 carcass, 20-day adult    1 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    2 accessory gland, mated 4-day male    0 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    6 central nervous system, larvae L3    1 central nervous system, pupae P8    0 head, virgin 1-day female    0 head, virgin 4-day female    0 head, virgin 20-day female    0 head, mated 1-day female    1 head, mated 4-day female    0 head, mated 20-day female    0 head, mated 1-day male    0 head, mated 4-day male    0 head, mated 20-day male    0 salivary gland, larvae L3 wandering    14 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    0 digestive system, 4-day adult    1 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    1 fat body, pupae P8    0 carcass, larvae L3 wandering    4 carcass, 1-day adult    1 carcass, 4-day adult    1 carcass, 20-day adult    1 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    2 accessory gland, mated 4-day male    0 Expression Level Scale  Very low   Low   Moderate  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    6 central nervous system, larvae L3    1 central nervous system, pupae P8    0 head, virgin 1-day female    0 head, virgin 4-day female    0 head, virgin 20-day female    0 head, mated 1-day female    1 head, mated 4-day female    0 head, mated 20-day female    0 head, mated 1-day male    0 head, mated 4-day male    0 head, mated 20-day male    0 salivary gland, larvae L3 wandering    14 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    0 digestive system, 4-day adult    1 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    1 fat body, pupae P8    0 carcass, larvae L3 wandering    4 carcass, 1-day adult    1 carcass, 4-day adult    1 carcass, 20-day adult    1 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    2 accessory gland, mated 4-day male    0 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    6 central nervous system, larvae L3    1 central nervous system, pupae P8    0 head, virgin 1-day female    0 head, virgin 4-day female    0 head, virgin 20-day female    0 head, mated 1-day female    1 head, mated 4-day female    0 head, mated 20-day female    0 head, mated 1-day male    0 head, mated 4-day male    0 head, mated 20-day male    0 salivary gland, larvae L3 wandering    14 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    0 digestive system, 4-day adult    1 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    1 fat body, pupae P8    0 carcass, larvae L3 wandering    4 carcass, 1-day adult    1 carcass, 4-day adult    1 carcass, 20-day adult    1 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    2 accessory gland, mated 4-day male    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    6 central nervous system, larvae L3    1 central nervous system, pupae P8    0 head, virgin 1-day female    0 head, virgin 4-day female    0 head, virgin 20-day female    0 head, mated 1-day female    1 head, mated 4-day female    0 head, mated 20-day female    0 head, mated 1-day male    0 head, mated 4-day male    0 head, mated 20-day male    0 salivary gland, larvae L3 wandering    14 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    0 digestive system, 4-day adult    1 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    1 fat body, pupae P8    0 carcass, larvae L3 wandering    4 carcass, 1-day adult    1 carcass, 4-day adult    1 carcass, 20-day adult    1 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    2 accessory gland, mated 4-day male    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of very low expression. Peak expression observed within 06-12 hour embryonic stages. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    2 embryo 04-06hr    9 embryo 06-08hr    36 embryo 08-10hr    24 embryo 10-12hr    6 embryo 12-14hr    4 embryo 14-16hr    1 embryo 16-18hr    1 embryo 18-20hr    1 embryo 20-22hr    0 embryo 22-24hr    0 larva L1    0 larva L2    1 larva L3 12hr old    0 larva L3 puffstage 1-2    2 larva L3 puffstage 3-6    3 larva L3 puffstage 7-9    2 white prepupae new    2 white prepupae 12hr    7 white prepupae 24hr    2 pupae 2d postWPP    1 pupae 3d postWPP    1 pupae 4d postWPP    1 adult male 01day    1 adult male 05day    1 adult male 30day    1 adult female 01day    0 adult female 05day    0 adult female 30day    0 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    2 embryo 04-06hr    9 embryo 06-08hr  (36) embryo 08-10hr    24 embryo 10-12hr    6 embryo 12-14hr    4 embryo 14-16hr    1 embryo 16-18hr    1 embryo 18-20hr    1 embryo 20-22hr    0 embryo 22-24hr    0 larva L1    0 larva L2    1 larva L3 12hr old    0 larva L3 puffstage 1-2    2 larva L3 puffstage 3-6    3 larva L3 puffstage 7-9    2 white prepupae new    2 white prepupae 12hr    7 white prepupae 24hr    2 pupae 2d postWPP    1 pupae 3d postWPP    1 pupae 4d postWPP    1 adult male 01day    1 adult male 05day    1 adult male 30day    1 adult female 01day    0 adult female 05day    0 adult female 30day    0 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    2 embryo 04-06hr    9 embryo 06-08hr    36 embryo 08-10hr    24 embryo 10-12hr    6 embryo 12-14hr    4 embryo 14-16hr    1 embryo 16-18hr    1 embryo 18-20hr    1 embryo 20-22hr    0 embryo 22-24hr    0 larva L1    0 larva L2    1 larva L3 12hr old    0 larva L3 puffstage 1-2    2 larva L3 puffstage 3-6    3 larva L3 puffstage 7-9    2 white prepupae new    2 white prepupae 12hr    7 white prepupae 24hr    2 pupae 2d postWPP    1 pupae 3d postWPP    1 pupae 4d postWPP    1 adult male 01day    1 adult male 05day    1 adult male 30day    1 adult female 01day    0 adult female 05day    0 adult female 30day    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    2 embryo 04-06hr    9 embryo 06-08hr    36 embryo 08-10hr    24 embryo 10-12hr    6 embryo 12-14hr    4 embryo 14-16hr    1 embryo 16-18hr    1 embryo 18-20hr    1 embryo 20-22hr    0 embryo 22-24hr    0 larva L1    0 larva L2    1 larva L3 12hr old    0 larva L3 puffstage 1-2    2 larva L3 puffstage 3-6    3 larva L3 puffstage 7-9    2 white prepupae new    2 white prepupae 12hr    7 white prepupae 24hr    2 pupae 2d postWPP    1 pupae 3d postWPP    1 pupae 4d postWPP    1 adult male 01day    1 adult male 05day    1 adult male 30day    1 adult female 01day    0 adult female 05day    0 adult female 30day    0 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    2 embryo 04-06hr    9 embryo 06-08hr    36 embryo 08-10hr    24 embryo 10-12hr    6 embryo 12-14hr    4 embryo 14-16hr    1 embryo 16-18hr    1 embryo 18-20hr    1 embryo 20-22hr    0 embryo 22-24hr    0 larva L1    0 larva L2    1 larva L3 12hr old    0 larva L3 puffstage 1-2    2 larva L3 puffstage 3-6    3 larva L3 puffstage 7-9    2 white prepupae new    2 white prepupae 12hr    7 white prepupae 24hr    2 pupae 2d postWPP    1 pupae 3d postWPP    1 pupae 4d postWPP    1 adult male 01day    1 adult male 05day    1 adult male 30day    1 adult female 01day    0 adult female 05day    0 adult female 30day    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    2 embryo 04-06hr    9 embryo 06-08hr  (36) embryo 08-10hr    24 embryo 10-12hr    6 embryo 12-14hr    4 embryo 14-16hr    1 embryo 16-18hr    1 embryo 18-20hr    1 embryo 20-22hr    0 embryo 22-24hr    0 larva L1    0 larva L2    1 larva L3 12hr old    0 larva L3 puffstage 1-2    2 larva L3 puffstage 3-6    3 larva L3 puffstage 7-9    2 white prepupae new    2 white prepupae 12hr    7 white prepupae 24hr    2 pupae 2d postWPP    1 pupae 3d postWPP    1 pupae 4d postWPP    1 adult male 01day    1 adult male 05day    1 adult male 30day    1 adult female 01day    0 adult female 05day    0 adult female 30day    0 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    2 embryo 04-06hr    9 embryo 06-08hr    36 embryo 08-10hr    24 embryo 10-12hr    6 embryo 12-14hr    4 embryo 14-16hr    1 embryo 16-18hr    1 embryo 18-20hr    1 embryo 20-22hr    0 embryo 22-24hr    0 larva L1    0 larva L2    1 larva L3 12hr old    0 larva L3 puffstage 1-2    2 larva L3 puffstage 3-6    3 larva L3 puffstage 7-9    2 white prepupae new    2 white prepupae 12hr    7 white prepupae 24hr    2 pupae 2d postWPP    1 pupae 3d postWPP    1 pupae 4d postWPP    1 adult male 01day    1 adult male 05day    1 adult male 30day    1 adult female 01day    0 adult female 05day    0 adult female 30day    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    2 embryo 04-06hr    9 embryo 06-08hr    36 embryo 08-10hr    24 embryo 10-12hr    6 embryo 12-14hr    4 embryo 14-16hr    1 embryo 16-18hr    1 embryo 18-20hr    1 embryo 20-22hr    0 embryo 22-24hr    0 larva L1    0 larva L2    1 larva L3 12hr old    0 larva L3 puffstage 1-2    2 larva L3 puffstage 3-6    3 larva L3 puffstage 7-9    2 white prepupae new    2 white prepupae 12hr    7 white prepupae 24hr    2 pupae 2d postWPP    1 pupae 3d postWPP    1 pupae 4d postWPP    1 adult male 01day    1 adult male 05day    1 adult male 30day    1 adult female 01day    0 adult female 05day    0 adult female 30day    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    1 cold shock, 4-day adult    1 heat shock, 4-day adult    4 Cadmium 50 mM 6 hrs, larvae L3    4 Cadmium 50 mM 12 hrs, larvae L3    4 Cadmium 50 mM 48 hrs, 4-day adult    3 Cadmium 100 mM 48 hrs, 4-day adult    0 Copper 0.5 mM 12 hrs, larvae L3    10 Copper 15 mM 48 hrs, 4-day adult    1 Zinc 5 mM 12 hrs, larvae L3    12 Zinc 4.5 mM 48 hrs, 4-day adult    2 Ethanol 2.5% 3 hrs, larvae L3    1 Ethanol 5% 3 hrs, larvae L3    4 Ethanol 10% 3 hrs, larvae L3    5 Caffeine 1.5 mg/ml 4 hrs, larvae L3    5 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    0 Caffeine 25 mg/ml 48 hrs, 4-day adult    1 Paraquat 5 mM 48 hrs, 4-day adult    1 Paraquat 10 mM 48 hrs, 4-day adult    1 Rotenone 2 μg 12 hrs, larvae L3    4 Rotenone 8 μg 12 hrs, larvae L3    3 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    1 cold shock, 4-day adult    1 heat shock, 4-day adult    4 Cadmium 50 mM 6 hrs, larvae L3    4 Cadmium 50 mM 12 hrs, larvae L3    4 Cadmium 50 mM 48 hrs, 4-day adult    3 Cadmium 100 mM 48 hrs, 4-day adult    0 Copper 0.5 mM 12 hrs, larvae L3    10 Copper 15 mM 48 hrs, 4-day adult    1 Zinc 5 mM 12 hrs, larvae L3    12 Zinc 4.5 mM 48 hrs, 4-day adult    2 Ethanol 2.5% 3 hrs, larvae L3    1 Ethanol 5% 3 hrs, larvae L3    4 Ethanol 10% 3 hrs, larvae L3    5 Caffeine 1.5 mg/ml 4 hrs, larvae L3    5 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    0 Caffeine 25 mg/ml 48 hrs, 4-day adult    1 Paraquat 5 mM 48 hrs, 4-day adult    1 Paraquat 10 mM 48 hrs, 4-day adult    1 Rotenone 2 μg 12 hrs, larvae L3    4 Rotenone 8 μg 12 hrs, larvae L3    3 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    1 cold shock, 4-day adult    1 heat shock, 4-day adult    4 Cadmium 50 mM 6 hrs, larvae L3    4 Cadmium 50 mM 12 hrs, larvae L3    4 Cadmium 50 mM 48 hrs, 4-day adult    3 Cadmium 100 mM 48 hrs, 4-day adult    0 Copper 0.5 mM 12 hrs, larvae L3    10 Copper 15 mM 48 hrs, 4-day adult    1 Zinc 5 mM 12 hrs, larvae L3    12 Zinc 4.5 mM 48 hrs, 4-day adult    2 Ethanol 2.5% 3 hrs, larvae L3    1 Ethanol 5% 3 hrs, larvae L3    4 Ethanol 10% 3 hrs, larvae L3    5 Caffeine 1.5 mg/ml 4 hrs, larvae L3    5 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    0 Caffeine 25 mg/ml 48 hrs, 4-day adult    1 Paraquat 5 mM 48 hrs, 4-day adult    1 Paraquat 10 mM 48 hrs, 4-day adult    1 Rotenone 2 μg 12 hrs, larvae L3    4 Rotenone 8 μg 12 hrs, larvae L3    3 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    1 cold shock, 4-day adult    1 heat shock, 4-day adult    4 Cadmium 50 mM 6 hrs, larvae L3    4 Cadmium 50 mM 12 hrs, larvae L3    4 Cadmium 50 mM 48 hrs, 4-day adult    3 Cadmium 100 mM 48 hrs, 4-day adult    0 Copper 0.5 mM 12 hrs, larvae L3    10 Copper 15 mM 48 hrs, 4-day adult    1 Zinc 5 mM 12 hrs, larvae L3    12 Zinc 4.5 mM 48 hrs, 4-day adult    2 Ethanol 2.5% 3 hrs, larvae L3    1 Ethanol 5% 3 hrs, larvae L3    4 Ethanol 10% 3 hrs, larvae L3    5 Caffeine 1.5 mg/ml 4 hrs, larvae L3    5 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    0 Caffeine 25 mg/ml 48 hrs, 4-day adult    1 Paraquat 5 mM 48 hrs, 4-day adult    1 Paraquat 10 mM 48 hrs, 4-day adult    1 Rotenone 2 μg 12 hrs, larvae L3    4 Rotenone 8 μg 12 hrs, larvae L3    3 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    1 cold shock, 4-day adult    1 heat shock, 4-day adult    4 Cadmium 50 mM 6 hrs, larvae L3    4 Cadmium 50 mM 12 hrs, larvae L3    4 Cadmium 50 mM 48 hrs, 4-day adult    3 Cadmium 100 mM 48 hrs, 4-day adult    0 Copper 0.5 mM 12 hrs, larvae L3    10 Copper 15 mM 48 hrs, 4-day adult    1 Zinc 5 mM 12 hrs, larvae L3    12 Zinc 4.5 mM 48 hrs, 4-day adult    2 Ethanol 2.5% 3 hrs, larvae L3    1 Ethanol 5% 3 hrs, larvae L3    4 Ethanol 10% 3 hrs, larvae L3    5 Caffeine 1.5 mg/ml 4 hrs, larvae L3    5 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    0 Caffeine 25 mg/ml 48 hrs, 4-day adult    1 Paraquat 5 mM 48 hrs, 4-day adult    1 Paraquat 10 mM 48 hrs, 4-day adult    1 Rotenone 2 μg 12 hrs, larvae L3    4 Rotenone 8 μg 12 hrs, larvae L3    3 Expression Level Scale  Very low   Low   Moderate  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    1 cold shock, 4-day adult    1 heat shock, 4-day adult    4 Cadmium 50 mM 6 hrs, larvae L3    4 Cadmium 50 mM 12 hrs, larvae L3    4 Cadmium 50 mM 48 hrs, 4-day adult    3 Cadmium 100 mM 48 hrs, 4-day adult    0 Copper 0.5 mM 12 hrs, larvae L3    10 Copper 15 mM 48 hrs, 4-day adult    1 Zinc 5 mM 12 hrs, larvae L3    12 Zinc 4.5 mM 48 hrs, 4-day adult    2 Ethanol 2.5% 3 hrs, larvae L3    1 Ethanol 5% 3 hrs, larvae L3    4 Ethanol 10% 3 hrs, larvae L3    5 Caffeine 1.5 mg/ml 4 hrs, larvae L3    5 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    0 Caffeine 25 mg/ml 48 hrs, 4-day adult    1 Paraquat 5 mM 48 hrs, 4-day adult    1 Paraquat 10 mM 48 hrs, 4-day adult    1 Rotenone 2 μg 12 hrs, larvae L3    4 Rotenone 8 μg 12 hrs, larvae L3    3 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    1 cold shock, 4-day adult    1 heat shock, 4-day adult    4 Cadmium 50 mM 6 hrs, larvae L3    4 Cadmium 50 mM 12 hrs, larvae L3    4 Cadmium 50 mM 48 hrs, 4-day adult    3 Cadmium 100 mM 48 hrs, 4-day adult    0 Copper 0.5 mM 12 hrs, larvae L3    10 Copper 15 mM 48 hrs, 4-day adult    1 Zinc 5 mM 12 hrs, larvae L3    12 Zinc 4.5 mM 48 hrs, 4-day adult    2 Ethanol 2.5% 3 hrs, larvae L3    1 Ethanol 5% 3 hrs, larvae L3    4 Ethanol 10% 3 hrs, larvae L3    5 Caffeine 1.5 mg/ml 4 hrs, larvae L3    5 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    0 Caffeine 25 mg/ml 48 hrs, 4-day adult    1 Paraquat 5 mM 48 hrs, 4-day adult    1 Paraquat 10 mM 48 hrs, 4-day adult    1 Rotenone 2 μg 12 hrs, larvae L3    4 Rotenone 8 μg 12 hrs, larvae L3    3 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    1 cold shock, 4-day adult    1 heat shock, 4-day adult    4 Cadmium 50 mM 6 hrs, larvae L3    4 Cadmium 50 mM 12 hrs, larvae L3    4 Cadmium 50 mM 48 hrs, 4-day adult    3 Cadmium 100 mM 48 hrs, 4-day adult    0 Copper 0.5 mM 12 hrs, larvae L3    10 Copper 15 mM 48 hrs, 4-day adult    1 Zinc 5 mM 12 hrs, larvae L3    12 Zinc 4.5 mM 48 hrs, 4-day adult    2 Ethanol 2.5% 3 hrs, larvae L3    1 Ethanol 5% 3 hrs, larvae L3    4 Ethanol 10% 3 hrs, larvae L3    5 Caffeine 1.5 mg/ml 4 hrs, larvae L3    5 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    0 Caffeine 25 mg/ml 48 hrs, 4-day adult    1 Paraquat 5 mM 48 hrs, 4-day adult    1 Paraquat 10 mM 48 hrs, 4-day adult    1 Rotenone 2 μg 12 hrs, larvae L3    4 Rotenone 8 μg 12 hrs, larvae L3    3 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010, Graveley et al., 2011) mE2_34_mRNA_expression_cluster_31 mE1_20_mRNA_expression_cluster_07
External Data & Images
Linkouts	BDGP expression data • IP01345 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0002573 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG32120-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal sensunspecified lethal | pupal stage, with Scer\GAL4pnr-MD237 sensGD4585 lethal | recessive sensE1 sensE2 sensE53 sensE54 sensE58 sensE64 sensE69 sensI235 sensM256 sensM608 sensSX67R12 Other Phenotypes Allele increased cell death sensE2 neuroanatomy defective sensE58 visible sensLy-2 visible, with Scer\GAL4bbg-C96 sensScer\UAS.cNa visible, with Scer\GAL4C1003 sensScer\UAS.cNa visible, with Scer\GAL4dpp.blk1 sensScer\UAS.cNa visible, with Scer\GAL4Eq1 sensScer\UAS.cNa visible, with Scer\GAL4lz-gal4 sensScer\UAS.cNa visible, with Scer\GAL4vg.PU sensScer\UAS.cNa visible (with sensLy-1) sensSX67 visible (with sensSX67) sensLy-1 visible | cell autonomous | recessive | somatic clone sensE2 visible | dominant sensLy-1 visible | somatic clone sensE2 wild-type sens+t11 sensLy-1rv3 sensLy-1rv11 Phenotype manifest in Allele abdominal dorsal multidendritic neuron ddaE & dendrite sensE58 anterior wing margin sensLy-1 axon & photoreceptor cell R7 | somatic clone, with Scer\GAL4tub.PU sensScer\UAS.cNa chaeta | cell autonomous | somatic clone sensE2 chaeta | ectopic, with Scer\GAL4Eq1 sensScer\UAS.cNa chaeta | ectopic, with Scer\GAL4vg.PU sensScer\UAS.cNa chaeta | somatic clone sensE2 chordotonal organ sensI235 sensM256 sensM608 dorsal multidendritic neuron ddaE & dendrite sensE58 dorsal row | somatic clone sensE2 embryonic/larval oenocyte precursor sensE2 embryonic/larval salivary gland sensE2 sensE58 sensI235 embryonic peripheral nervous system & neuron (with Df(3L)S122804) sensM256 eo neuron | somatic clone | supernumerary sensE2 external sensory organ sensI235 sensM256 sensM608 external sensory organ (with Df(3L)S122804) sensM256 external sensory organ precursor cell IIa | somatic clone sensE2 external sensory organ precursor cell IIb | somatic clone | supernumerary sensE2 eye sensLy-2 eye, with Scer\GAL4lz-gal4 sensScer\UAS.cNa interommatidial bristle | ectopic, with Scer\GAL4lz-gal4 sensScer\UAS.cNa leg & chaeta, with Scer\GAL4dpp.blk1 sensScer\UAS.cNa leg | distal, with Scer\GAL4dpp.blk1 sensScer\UAS.cNa leg sensillum, with Scer\GAL4dpp.blk1 sensScer\UAS.cNa macrochaeta | ectopic, with Scer\GAL4dpp.blk1 sensScer\UAS.cNa macrochaeta | ectopic, with Scer\GAL4sca-109-68 sensScer\UAS.cNa macrochaeta | ectopic, with Scer\GAL4sca-537.4 sensScer\UAS.cNa mechanosensory chaeta | somatic clone sensE2 mechanosensory sensory organ | supernumerary, with Scer\GAL4sca-537.4 sensScer\UAS.cNa medulla | somatic clone, with Scer\GAL4sca-109-68, sensE2 sensScer\UAS.cNa medulla | somatic clone, with Scer\GAL4sca-109-68, sensScer\UAS.cNa sensE2 mesothoracic bristle | ectopic, with Scer\GAL4dpp.blk1 sensScer\UAS.cNa mesothoracic bristle | ectopic, with Scer\GAL4Eq1 sensScer\UAS.cNa sens1CC.Scer\UAS sens4CC.Scer\UAS sensL2-T-E.Scer\UAS metathoracic bristle | ectopic, with Scer\GAL4Eq1 sensScer\UAS.cNa sens1CC.Scer\UAS sens4CC.Scer\UAS sensL2-T-E.Scer\UAS microchaeta & scutellum | ectopic, with Scer\GAL4C5 sensScer\UAS.cNa microchaeta | cell autonomous | somatic clone sensE2 microchaeta | ectopic, with Scer\GAL4sca-109-68 sensScer\UAS.cNa microchaeta | ectopic, with Scer\GAL4sca-537.4 sensScer\UAS.cNa multidendritic neuron sensI235 sensM256 sensM608 ommatidium, with Scer\GAL4lz-gal4 sensScer\UAS.cNa ommatidium | somatic clone, with Scer\GAL4elav-C155 sensScer\UAS.cNa ommatidium | somatic clone (with sensE1) sensE2 ommatidium | somatic clone (with sensE2) sensE1 photoreceptor cell R2 | somatic clone sensE2 photoreceptor cell R5 | somatic clone sensE2 photoreceptor cell R7 | somatic clone (with sensE1) sensE2 photoreceptor cell R7 | somatic clone (with sensE2) sensE1 photoreceptor cell R8 | cell non-autonomous | somatic clone (with sensE1) sensE2 photoreceptor cell R8 | cell non-autonomous | somatic clone (with sensE2) sensE1 photoreceptor cell R8 | somatic clone sensE2 photoreceptor cell R8 | somatic clone (with sensE1) sensE2 photoreceptor cell R8 | somatic clone (with sensE2) sensE1 PNS glial cell (with Df(3L)S122804) sensM256 posterior wing margin sensLy-1 postorbital bristle | somatic clone sensE2 presumptive embryonic/larval peripheral nervous system (with Df(3L)S122804) sensM256 prothoracic tarsal bristle | ectopic, with Scer\GAL4Eq1 sensScer\UAS.cNa sens1CC.Scer\UAS sens4CC.Scer\UAS sensL2-T-E.Scer\UAS scutum, with Scer\GAL4dpp.blk1 sensScer\UAS.cNa scutum & chaeta, with Scer\GAL4dpp.blk1 sensScer\UAS.cNa secondary pigment cell, with Scer\GAL4lz-gal4 sensScer\UAS.cNa sensillum campaniformium of dorsal radius, with Scer\GAL4dpp.blk1 sensScer\UAS.cNa sensillum campaniformium of dorsal radius | supernumerary, with Scer\GAL4sca-109-68 sensScer\UAS.cNa sternopleural bristle, with Scer\GAL4dpp.blk1 sensScer\UAS.cNa tertiary pigment cell, with Scer\GAL4lz-gal4 sensScer\UAS.cNa thecogen cell (with Df(3L)S122804) sensM256 thecogen cell | somatic clone sensE2 tormogen cell | cell autonomous | somatic clone sensE2 tormogen cell | somatic clone sensE2 trichogen cell | somatic clone sensE2 trichome of the posterior wing margin | somatic clone sensE2 ventral row | somatic clone sensE2 wing sensLy-1 wing, with Scer\GAL4dpp.blk1 sensScer\UAS.cNa wing & chaeta, with Scer\GAL4dpp.blk1 sensScer\UAS.cNa wing margin, with Scer\GAL4bbg-C96 sensScer\UAS.cNa wing margin, with Scer\GAL4C1003 sensScer\UAS.cNa wing margin, with Scer\GAL4dpp.blk1 sensScer\UAS.cNa wing margin (with sensLy-1) sensSX67 wing margin (with sensSX67) sensLy-1 wing sensillum, with Scer\GAL4dpp.blk1 sensScer\UAS.cNa wing sensillum | ectopic, with Scer\GAL4dpp.blk1 sensScer\UAS.cNa
Classical Alleles ( 22 )
For All Classical Alleles Show
Allele of sens Class Mutagen Stocks Known lesion sensLy-1 gain of function allele X ray 30 Yes sensE2 amorphic allele - genetic evidence, loss of function allele ethyl methanesulfonate 4 Yes sensE58 loss of function allele ethyl methanesulfonate 2 Yes sensf06181 piggyBac transposase 2 -- sensI235 loss of function allele ethyl methanesulfonate 1 -- sensMB02566 1 -- sensE1 loss of function allele ethyl methanesulfonate 0 -- sensE53 loss of function allele ethyl methanesulfonate 0 -- sensE54 loss of function allele ethyl methanesulfonate 0 -- sensE64 ethyl methanesulfonate 0 -- sensE69 loss of function allele ethyl methanesulfonate 0 -- sensE87 0 -- sensLy-1rv10 X ray 0 -- sensLy-1rv11 X ray 0 -- sensLy-1rv3 X ray 0 -- sensLy-1rv5 0 -- sensLy-2 spontaneous MR 0 -- sensM256 loss of function allele ethyl methanesulfonate 0 -- sensM608 ethyl methanesulfonate 0 -- sensSX67 gain of function allele X ray 0 -- sensSX67R12 X ray 0 -- sensunspecified 0 --
Alleles Carried on Transgenic Constructs ( 23 )
For All Alleles Carried on Transgenic Constructs Show
Allele of sens Class Mutagen Stocks Known lesion sensScer\UAS.cNa in vitro construct - regulatory fusion 2 Yes sensGD4585 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes sensJF02575 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes sensKK112921 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes sensT:Zzzz\FLAG,T:Zzzz\TEV.CS,T:Zzzz\StrepII,T:Avic\GFP-EGFP,T:Zzzz\TC in vitro construct - coding region fusion 1 Yes sens+t11 in vitro construct - genomic fragment 0 Yes sens+t12.1 in vitro construct - genomic fragment 0 Yes sens+t18.1 in vitro construct - genomic fragment 0 Yes sens1CC.Scer\UAS in vitro construct - regulatory fusion in vitro construct - site directed mutagenesis 0 Yes sens1CCg in vitro construct - genomic fragment in vitro construct - site directed mutagenesis 0 Yes sens2CC.Scer\UAS in vitro construct - regulatory fusion in vitro construct - site directed mutagenesis 0 Yes sens2CCg in vitro construct - genomic fragment in vitro construct - site directed mutagenesis 0 Yes sens3CC.Scer\UAS in vitro construct - regulatory fusion in vitro construct - site directed mutagenesis 0 Yes sens3CCg in vitro construct - genomic fragment in vitro construct - site directed mutagenesis 0 Yes sens4CC.Scer\UAS in vitro construct - regulatory fusion in vitro construct - site directed mutagenesis 0 Yes sens4CCg in vitro construct - genomic fragment in vitro construct - site directed mutagenesis 0 Yes sensAct5C.PJ in vitro construct - regulatory fusion 0 Yes sensdel.Act5C in vitro construct - regulatory fusion 0 Yes sensg.+t in vitro construct - genomic fragment 0 Yes sensGDBD.Act5C.Scer\GAL4 in vitro construct - coding region fusion in vitro construct - regulatory fusion 0 Yes sensL2-T-E.Scer\UAS in vitro construct - regulatory fusion in vitro construct - amino acid replacement 0 Yes sensNIG.32120R in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes senstCH322-01N16 in vitro construct - genomic fragment 0 Yes
Aneuploid Aberrations
Disrupted in	Df(3L)BSC614 (Christensen et al., 2008.9.29) Df(3L)Ly (Bloomington Drosophila Stock Center, 1999.7.3) Df(3L)M69E (Dunn and Mossige, 1937) Df(3L)S122804 (Nolo et al., 2000, Nolo et al., 2001) Df(3L)Δ130 (Nolo et al., 2001)
Not disrupted in	Df(3L)BSC15 (Deal and Cook, 2002.2.24) Df(3R)by10 (Salzberg et al., 1997) Df(3R)by62 (Szeged Stock Center, 1998-, Salzberg et al., 1997) Df(3R)GB104 (Salzberg et al., 1997)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD4585} NA P{KK112921} NA P{NIG.32120R} NA P{TRiP.JF02575} NA P{UAS-sens.1CC} NA P{UAS-sens.2CC} NA P{UAS-sens.3CC} NA P{UAS-sens.4CC} NA P{UAS-sens.L2-T-E} NA reporter construct P{sens.8-lacZ} No P{sens.9.1.mut-lacZ} No P{sens.9.1-lacZ} No GAL4 construct P{sens-GAL4.B} No characterization construct P{sens.1CCg} NA P{sens.2CCg} NA P{sens.3CCg} NA P{sens.4CCg} NA P{sens+} NA P{sens+t12.1} NA P{sens+t18.1} NA PBac{CH322-01N16} NA PBac{FTSF.GFP-sens} NA
Insertions
	Type of insertions Name Expression data miscellaneous insertions PBac{WH}sensf06181 NA insertion of enhancer trap binary system Mi{ET1}sensMB02566 No
Gene Ontology: Function, Process & Cellular Component ( 22 unique terms )
Terms Based on Experimental Evidence ( 17 terms )
Molecular Function
CV term Evidence References
bHLH transcription factor binding inferred from direct assay (Acar et al., 2006) contributes_to RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription inferred from direct assay (McDonald et al., 2010) RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity inferred from direct assay (Li-Kroeger et al., 2008) sequence-specific DNA binding inferred from direct assay (Li-Kroeger et al., 2008)
Biological Process
CV term Evidence References
axon guidance inferred from mutant phenotype (Morey et al., 2008) chaeta morphogenesis inferred from mutant phenotype (Wildonger and Mann, 2005) compound eye photoreceptor development inferred from mutant phenotype (Frankfort and Mardon, 2004) dendrite morphogenesis inferred from mutant phenotype (Parrish et al., 2006) negative regulation of apoptotic process inferred from mutant phenotype (Sprecher and Desplan, 2008) negative regulation of transcription from RNA polymerase II promoter inferred from direct assay (Li-Kroeger et al., 2008) neuron development inferred from mutant phenotype (Parrish et al., 2006) peripheral nervous system development inferred from mutant phenotype (Nolo et al., 2000) photoreceptor cell morphogenesis inferred from genetic interaction with ro AND inferred from mutant phenotype (Frankfort et al., 2001) R8 cell differentiation inferred from mutant phenotype (Frankfort and Mardon, 2003) sensory organ development inferred from genetic interaction with da (Jafar-Nejad et al., 2006) inferred from genetic interaction with sc (Jafar-Nejad et al., 2006) inferred from mutant phenotype (Jafar-Nejad et al., 2006, Acar et al., 2006) sensory organ precursor cell fate determination inferred from mutant phenotype (Jafar-Nejad et al., 2006)
Cellular Component
CV term Evidence References
nucleus inferred from direct assay (Tomasi et al., 2008, Li-Kroeger et al., 2008)
Terms Based on Predictions or Assertions ( 9 terms )
Molecular Function
CV term Evidence References
sequence-specific DNA binding transcription factor activity non-traceable author statement (Frankfort and Mardon, 2002) zinc ion binding inferred from electronic annotation with InterPro:IPR001878, InterPro:IPR007087, InterPro:IPR015880 (FlyBase Curators et al., 2004-)
Biological Process
CV term Evidence References
negative regulation of epidermal growth factor receptor signaling pathway non-traceable author statement (Frankfort and Mardon, 2003) peripheral nervous system development non-traceable author statement (Prokopenko et al., 2000) traceable author statement (Salzberg et al., 1994) R8 cell differentiation non-traceable author statement (Frankfort and Mardon, 2002) NOT R8 cell fate specification non-traceable author statement (Frankfort and Mardon, 2003) regulation of transcription, DNA-dependent non-traceable author statement (Nolo, 1999.12.6) sensory organ development traceable author statement (Treisman, 2004)
Cellular Component
CV term Evidence References
nucleus non-traceable author statement (Nolo, 1999.12.6)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
protein-protein
Interacting group Assay References
sens - CG4847 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23)
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions sens allele Gene References sensE1 ro (Frankfort et al., 2001) sensE2 rho (Frankfort and Mardon, 2004) ro (Frankfort et al., 2001) sc (Nolo et al., 2000) W (Chandrasekaran and Beckendorf, 2003) sensLy-1 sd (Srivastava and Bell, 2003) Snr1 (Marenda et al., 2004) sensScer\UAS.cNa ac (Jafar-Nejad et al., 2003) E(spl)m8-HLH (Nolo et al., 2000) sc (Nolo et al., 2000) sd (Srivastava and Bell, 2003) sensunspecified M(3)80 (Sinclair et al., 1984) unspecified ab (Parrish et al., 2006) Caf1 (Pepple et al., 2007) da (Jafar-Nejad et al., 2006) Dl (Pepple et al., 2007) E(ls)1 (Pepple et al., 2007) E(ls)3 (Pepple et al., 2007) fkh (Chandrasekaran and Beckendorf, 2003) MEP-1 (Parrish et al., 2006) mir-9a (Li et al., 2006) msk (Pepple et al., 2007) nvy (Wildonger and Mann, 2005) rho (Sturtevant and Bier, 1995) rpr (Chandrasekaran and Beckendorf, 2003) S(ls)1 (Pepple et al., 2007) S(ls)5 (Pepple et al., 2007) S(ls)6 (Pepple et al., 2007) S(ls)7 (Pepple et al., 2007) sc (Jafar-Nejad et al., 2006) Su(z)12 (Parrish et al., 2006) Tango10 (Parrish et al., 2006)
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 69594 DroID - A comprehensive database of gene and protein interactions. • FBgn0002573 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 45328 SignaLink - A protein-protein and protein-miRNA interaction database with multi-layered structure and multiple confidence scores. • Q9N658
Orthologs
OrthoDB Orthologs (54) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG6STSQG Dipteran inclusive ortholog search EOG63216P Insect inclusive ortholog search EOG6RXWWC Arthropod inclusive ortholog search EOG641NST Metazoa inclusive ortholog search EOG622PFH
Orthologs in Drosophila Species (EOG6STSQG)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\sens     Drosophila simulans   Dsim\GD12667 Y   Drosophila sechellia   Dsec\GM24598 Y   Drosophila erecta   Dere\GG13774 Y   Drosophila yakuba   Dyak\GE20069 Y   Drosophila ananassae   Dana\GF10411 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA16696 Y   Drosophila persimilis   Dper\GL15695 Y   Drosophila willistoni   Dwil\GK12454 Y   Drosophila mojavensis   Dmoj\GI13460 Y   Drosophila grimshawi   Dgri\GH16734 Y
Orthologs in non-Drosophila Dipterans (EOG63216P)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ002496   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ012536
Orthologs in non-Dipteran Insects (EOG6RXWWC)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\Ame.2444   Apis mellifera Western honey bee  Amel\GB45532   Apis mellifera Western honey bee  Amel\GB40142   Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG006344   Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG012936   Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG012937   Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH20811   Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH13418   Atta cephalotes Leafcutter ant  Acep\ACEP13748   Atta cephalotes Leafcutter ant  Acep\ACEP24771   Camponotus floridanus Florida carpenter ant  Cflo\CFLO18696   Camponotus floridanus Florida carpenter ant  Cflo\CFLO26201   Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL18074   Linepithema humile Argentine ant  Lhum\LH22063   Pogonomyrmex barbatus Red harvester ant  Pbar\PB14050   Pogonomyrmex barbatus Red harvester ant  Pbar\PB19039   Solenopsis invicta Red fire ant  Sinv\SINV20314   Acyrthosiphon pisum Pea aphid  Apim\ACYPI001809   Bombyx mori Silkmoth  Bmor\BGIBMGA006132   Bombyx mori Silkmoth  Bmor\BGIBMGA003190   Pediculus humanus Human body louse  Phum\PHUM248200   Pediculus humanus Human body louse  Phum\PHUM248190   Tribolium castaneum Red flour beetle  Tcas\sens   Tribolium castaneum Red flour beetle  Tcas\GFI1
Orthologs in non-Insect Arthropods (EOG641NST)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\JGI_V11_113215   Ixodes scapularis Deer tick  Isca\ISCW020916
Orthologs in non-Arthropod Metazoa (EOG622PFH)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Caenorhabditis elegans Nematode  Cele\pag-3   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_012645gn   Danio rerio Zebrafish  Drer\si:ch211-231o6.2   Danio rerio Zebrafish  Drer\gfi1.1   Danio rerio Zebrafish  Drer\gfi1.2   Xenopus tropicalis Western clawed frog  Xtro\gfi1   Xenopus tropicalis Western clawed frog  Xtro\gfi1b   Gallus gallus Domestic chicken  Ggal\GFI1   Gallus gallus Domestic chicken  Ggal\GFI1B   Mus musculus House mouse  Mmus\Gfi1b   Mus musculus House mouse  Mmus\Gfi1   Rattus norvegicus Norway rat  Rnor\Gfi1   Rattus norvegicus Norway rat  Rnor\Gfi1b   Homo sapiens Human  Hsap\GFI1B   Homo sapiens Human  Hsap\GFI1
Human Orthologs (2)
Gene OMIM HGNC Hsap\GFI1B     Hsap\GFI1
AAA Orthologs (11) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD12667 Drosophila sechellia Dsec\GM24598 Drosophila erecta Dere\GG13774 Drosophila yakuba Dyak\GE20069 Drosophila ananassae Dana\GF10411 Drosophila pseudoobscura pseudoobscura Dpse\GA16696 Drosophila persimilis Dper\GL15695 Drosophila willistoni Dwil\GK12454 Drosophila virilis Dvir\GJ11823 Drosophila mojavensis Dmoj\GI13460 Drosophila grimshawi Dgri\GH16734
Stocks & Reagents
Stocks Listed in FlyBase ( 46 )
Bloomington	39681 y1 w* P{UAS-sens.N}C1 42209 y1 w*; P{UAS-sens.N}C12 38666 w1118; PBac{FTSF.GFP-sens}VK00022 23576 w1118; Mi{ET1}sensMB02566 532 Df(3L)Ly, sensLy-1 Sb1/LVM 27287 y1 v1; P{TRiP.JF02575}attP2
Harvard	- PBac{WH}sensf06181
Kyoto	107314 sensLy-1/CxD 105967 sensLy-1 Sb1/LVM 107636 se1 sensLy-1 dn1/LVM
VDRC	v106028 P{KK112921}VIE-260B v11690 w1118; P{GD4585}v11690
	More stocks available...
Genomic Clones ( 1 )
	BACR17E13 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 5 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	IP01345 IP01347
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones
Other clones	32372 bs22d10 EK141859
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0002573 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 45328
Antibody Information
	polyclonal antibody (Domingos et al., 2004)
Other Information
Discoverer
	Dubinin, 1929.
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of	Source for merge of: Ly sens l(3)70Ad (Nolo et al., 2000) Source for merge of: sens CG10714 (Bayraktaroglu, 2000.8.7)
Additional comments	The dominant phenotype associated with sens[Ly-1] cannot be recombined onto a "sens" mutant chromosome, indicating that both mutations map at the same site. (Nolo et al., 2000)
Other Comments
	DNA-protein interactions: genome-wide binding profile assayed for sens protein in 0-12 hr embryos; see mE1_TFBS_sens collection report. (Negre et al., 2011) sens physically interacts with sc, ato, ac, and da. The Zn-finger domains of sens mediate the interaction between sens and sc. Zn-finger 2 and 3 are indispensable for sens function. (Acar et al., 2006) sens plays a role in the development of all bristles but its role is different in subtypes of these organs. It is required for pI progeny fate specification in thoracic microchaetae, for pI selection and specification in wing margin chemoreceptors, and for proneural survival in wing margin mechanoreceptors. (Jafar-Nejad et al., 2006) dsRNA has been made from templates generated with primers directed against this gene. RNAi of sens causes extensive mixing of dendritic arbors from the ddaD and ddaE neurons, in addition to dorsal overextension of primary dendrites and an overall reduction in the number of class I da neurons. RNAi also causes alterations in the number of MD neurons, defects in dendrite morphogenesis and reproducible defects in da dendrite development. (Parrish et al., 2006) Residues 100-154, part of the AXH domain of Atx-1 are necessary and sufficient to allow a physical interaction with sens. (Tsuda et al., 2005) sens promotes normal R8 photoreceptor differentiation by preventing the effects of autocrine stimulation by spi, through transcriptional repression of pnt. (Frankfort and Mardon, 2004) sens repression of ro is required for R8 phototreceptor differentiation in the developing eye. (Frankfort et al., 2001) Proneural genes activate sens expression. sens is then required to further activate and maintain proneural gene expression. (Nolo et al., 2000) sens is both necessary and sufficient for peripheral nervous system development. (Nolo et al., 2000) Mutation in sens causes a loss of neurons. (Salzberg et al., 1994) sens is required for PNS development in the embryo. (Salzberg et al., 1994) A wing margin mutation that interacts additively with ct. sens causes tissue loss from the anterior and posterior wing margins. In double mutants of sens and ct46l and ct53d no part of the margin is lost that isn't lost in either of the mutants alone. (Jack and DeLotto, 1992) The components for positional information within the wing have been determined. (Abbott and Sprey, 1990)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_080079 RefSeq (Proteins) • NP_524818 DDBJ / EMBL / GenBank • AAF32280 AAF32281 AAN11834 AF212312 AF212313 BE662095 CZ488832 Entrez Gene - A searchable database of RefSeq genes. • 45328 UniProtKB/Swiss-Prot • Q9N658
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Zinc finger C2H2-type/integrase DNA-binding domain (IPR013087) Zinc finger, C2H2-like (IPR015880) Zinc finger, C2H2 (IPR007087) Zinc finger, CCHC-type (IPR001878) BDGP expression data - Patterns of gene expression in Drosophila embryogenesis • IP01345
Linkouts
	BioGRID - A database of protein and genetic interactions • 69594 DroID - A comprehensive database of gene and protein interactions. • FBgn0002573 DRSC - Results from RNAi screens. • FBgn0002573 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0002573 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG32120-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0002573 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 45328 Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution • /hjmuller/lyra1.htm InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 45328 modMine - Data generated by the modENCODE project. • FBgn0002573 SignaLink - A protein-protein and protein-miRNA interaction database with multi-layered structure and multiple confidence scores. • Q9N658
Synonyms & Secondary IDs ( 19 )
Reported As
Symbol Synonym	1228/04 (Deak et al., 1997) CG10714 (Whitfield, 2000.11.22, ) CG32120 (Keleman et al., 2009.8.5, Aerts et al., 2010) l(3)70Ad   Ly (Marenda et al., 2004, Nolo et al., 2001, Nolo et al., 2000, Szeged Stock Center, 1998-, Sinclair et al., 1984, Abbott and Zidar, 1999, Deak et al., 1997, Abbott, 1996, Coyne, 1935, Sturtevant and Bier, 1995, Carpenter, 1994, Abbott, 1994, Lindsley and Zimm, 1992, Morgan et al., 1937, Waddle, 1977, Jack and DeLotto, 1992, Garcia-Bellido and de Celis, 1992, Abbott and Sprey, 1990, Zhimulev and Feldman, 1982, Waddington, 1940, Waddington, 1939, Dunn and Mossige, 1937, Laffafian et al., 2010, Wang et al., 2009, Sharp and Agrawal, 2008, Clark et al., 2012) Ly-1 (Bloomington Drosophila Stock Center, 1999.7.3) Sen (Baeg et al., 2004, Goodman et al., 2006) sen (Zhang et al., 2006, Zhang et al., 2009) sens (Al-Ramahi et al., 2007, Li et al., 2006, Venken, 2006, DasGupta et al., 2005, Kreuger et al., 2004, Pepple et al., 2007, Xie and Cook, 2006, Janody and Treisman, 2006, Kent et al., 2006, Bartscherer et al., 2006, Hoskins et al., 2005, Venken et al., 2006, Kuranaga et al., 2006, Frankfort et al., 2004, Ebacher et al., 2007, Lubensky et al., 2011, Ayyar et al., 2007, Herr and Basler, 2012, Baena-Lopez et al., 2009, Seto and Bellen, 2006, Li-Kroeger et al., 2008, Xie et al., 2008, Gebelein et al., 2008, Hayward et al., 2005, Christensen et al., 2008.9.29, Kinel-Tahan et al., 2007, Zhu, 2011, Pennington and Lubensky, 2010, Nègre et al., 2011, Wu et al., 2009, Barad et al., 2010, Anderson et al., 2011, Wu et al., 2010, Loncle et al., 2007, Belenkaya et al., 2008, Li-Kroeger et al., 2008, Cao et al., 2007, Tien et al., 2008, Tyler and Baker, 2007, de la Roche and Bienz, 2007, Xie et al., 2007, Pepple et al., 2008, Asmar et al., 2008, Zeng et al., 2008, Bhattacharya and Baker, 2009, Piddini and Vincent, 2009, Sprecher and Desplan, 2008, Morey et al., 2008, Biryukova et al., 2009, Aerts et al., 2009, Choi et al., 2009, Franch-Marro et al., 2008, zur Lage et al., 2004, Yan et al., 2009, Kennell et al., 2008, Mieszczanek et al., 2008, Zhai et al., 2009, Perkins et al., 2009.8.10, Li et al., 2007, Morey et al., 2008, Venken et al., 2009, Endo et al., 2007, Bejarano et al., 2010, Buffin and Gho, 2010, Hermle et al., 2010, Buechling et al., 2010, Witt et al., 2010, Spokony and White, 2012.5.22, Wang et al., 2010, Pappu et al., 2011, Aerts et al., 2010, Cachero et al., 2011, Fiedler et al., 2011, de Navascués and Modolell, 2010, The modENCODE Consortium, 2010, The modENCODE Consortium, 2010, Song et al., 2010, Zhai et al., 2010, Lee and Fischer, 2012, Powell et al., 2008, Zhang et al., 2011, You et al., 2011, Karim and Moore, 2011, Bhattacharya and Baker, 2011, Gasnereau et al., 2011, Yu et al., 2012, Plavicki et al., 2012, Mendoza-Topaz et al., 2011, Japanese National Institute of Genetics, 2012.5.21, Mavromatakis and Tomlinson, 2012, Powell et al., 2012) Sens (McNeill et al., 2008, Pappu, 2005, Pappu et al., 2005, Gomes and Schweisguth, 2005, Quan et al., 2004, Parker et al., 2002, Zhang et al., 2005, Zhang et al., 2006, Mikeladze-Dvali et al., 2005, Rives et al., 2006, Roignant et al., 2006, Klein et al., 2006, Rogers et al., 2005, Banziger et al., 2006, Parrish et al., 2006, Fang et al., 2006, Legent et al., 2012, Egger-Adam and Katanaev, 2010, Hufnagel et al., 2006, Bose et al., 2006, Holohan et al., 2006, Seto and Bellen, 2006, Wu et al., 2008, Giagtzoglou et al., 2012, Becam et al., 2011, Guan et al., 2007, Yogev et al., 2010, Esteve et al., 2011, Duan et al., 2011, You et al., 2011, Smith et al., 2007, Katanaev et al., 2008, Herranz et al., 2008, Jaekel and Klein, 2006, Escudero et al., 2007, Gallet et al., 2008, Perdigoto et al., 2008, Miller et al., 2008, Miura et al., 2008, Chang et al., 2008, Rusten et al., 2006, Nagaraj and Banerjee, 2009, Chang et al., 2008, Mao and Freeman, 2009, Gomes et al., 2009, Benítez et al., 2009, Mulligan et al., 2012, Hödl and Basler, 2009, Andrews et al., 2009, Buceta et al., 2007, Kahali et al., 2009, O'Keefe et al., 2009, Bhattacharya and Baker, 2009, Baker et al., 2009, Li et al., 2009, Duong et al., 2008, Kandachar et al., 2008, Steele et al., 2009, Weber et al., 2008, Deb et al., 2008, Tanaka-Matakatsu et al., 2007, Chanet et al., 2009, Kanwar and Fortini, 2008, Tomasi et al., 2008, Mao et al., 2008, Herranz et al., 2006, Yan et al., 2009, zur Lage and Jarman, 2010, Beam and Moberg, 2010, Quijano et al., 2010, Mukai et al., 2010, Hamel et al., 2010, Roignant and Treisman, 2010, Li-Kroeger et al., 2012, Kleinschmit et al., 2010, Gross et al., 2012, Sánchez-Hernández et al., 2012, Silver et al., 2007, McDonald et al., 2010, Gutzwiller et al., 2010, Eivers et al., 2011, Rebeiz et al., 2011, Wu et al., 2012, Avanesov et al., 2012, Olson et al., 2011, Buechling et al., 2011, Hödl and Basler, 2012, Jusiak et al., 2012, Valenta et al., 2011, Kametaka et al., 2012, Quijano et al., 2011, Yanfeng et al., 2011, Nfonsam et al., 2012, Dornier et al., 2012, Chang et al., 2008) SENS (Bury et al., 2008) sense (Bateman and McNeill, 2004, Baig-Lewis et al., 2007) Ss (Balakireva et al., 2006)
Name Synonym	Lyra   senseless (Al-Ramahi et al., 2007, Jafar-Nejad and Bellen, 2004, Kennell and Cadigan, 2007, Xie and Cook, 2006, Bartscherer et al., 2006, Cohen et al., 2006, Ebacher et al., 2007, Ayyar et al., 2007, Herr and Basler, 2012, Zhang et al., 2006, Baena-Lopez et al., 2009, Kennell and Cadigan, 2008, Wu et al., 2008, Hayward et al., 2005, Kinel-Tahan et al., 2007, Harterink et al., 2011, Song et al., 2009, Loncle et al., 2007, Belenkaya et al., 2008, Tyler and Baker, 2007, de la Roche and Bienz, 2007, Pepple et al., 2008, Baig-Lewis et al., 2007, Franch-Marro et al., 2008, Petrovic and Hummel, 2008, Aerts et al., 2009, Buceta et al., 2007, Zhang et al., 2009, Zhai et al., 2009, Li et al., 2007, Babaoglan et al., 2009, Eivers et al., 2009, Bejarano et al., 2010, Zimmerman et al., 2010, Buffin and Gho, 2010, Mohan et al., 2010, Li-Kroeger et al., 2008, Witt et al., 2010, Wang et al., 2010, Fiedler et al., 2011, Song et al., 2010, Zhai et al., 2010, Bhattacharya and Baker, 2011, Hartl et al., 2011, Plavicki et al., 2012, Mendoza-Topaz et al., 2011, Mavromatakis and Tomlinson, 2012) Senseless (Wang et al., 2002, Lin et al., 2002, Yang and Baker, 2001, Goodman et al., 2006, Krisel and Moberg, 2007, Vrailas et al., 2006, Rodrigues et al., 2005, Jafar-Nejad et al., 2006, Strutt et al., 2006, Wei et al., 2005, Acar et al., 2006, Rogers et al., 2005, Egger-Adam and Katanaev, 2010, Hufnagel et al., 2006, Holohan et al., 2006, Li-Kroeger et al., 2008, Xie et al., 2008, Gebelein et al., 2008, Vrailas and Moses, 2006, Giagtzoglou et al., 2012, Liu and Lehmann, 2008, Becam et al., 2011, David et al., 2005, Guan et al., 2007, Pennington and Lubensky, 2010, Nègre et al., 2011, Singh et al., 2010, Gontang et al., 2011, Herranz et al., 2008, Cao et al., 2007, Xie et al., 2007, Miura et al., 2008, Chang et al., 2008, Rusten et al., 2006, Asmar et al., 2008, Popova et al., 2011, Tseng et al., 2007, Mao and Freeman, 2009, Sprecher and Desplan, 2008, Morey et al., 2008, Gomes et al., 2009, Mirth et al., 2009, Stern et al., 2009, Hödl and Basler, 2009, O'Keefe et al., 2009, Bhattacharya and Baker, 2009, Li et al., 2009, Baker et al., 2009, Duong et al., 2008, Kandachar et al., 2008, Steele et al., 2009, Deb et al., 2008, Shinza-Kameda et al., 2006, Tanaka-Matakatsu et al., 2007, Kanwar and Fortini, 2008, Tomasi et al., 2008, Mao et al., 2008, Herranz et al., 2006, Bury et al., 2008, zur Lage and Jarman, 2010, Beam and Moberg, 2010, Mukai et al., 2010, Cohen et al., 2010, Roignant and Treisman, 2010, Kleinschmit et al., 2010, Pappu et al., 2011, Djiane et al., 2011, Aerts et al., 2010, de Navascués and Modolell, 2010, McDonald et al., 2010, Gutzwiller et al., 2010, Eivers et al., 2011, Rebeiz et al., 2011, Avanesov et al., 2012, Buechling et al., 2011, Mukherjee et al., 2012, Miller et al., 2008, Balakireva et al., 2006, Valenta et al., 2011, Bray et al., 2008, Petrovic and Hummel, 2008, Kametaka et al., 2012, Stephan et al., 2011, Yanfeng et al., 2011, Dornier et al., 2012) sensesless (You et al., 2011) Sensless (Bhambhani et al., 2007, Perdigoto et al., 2008) sensSenseless (Silver et al., 2007)
Secondary FlyBase IDs
	FBgn0011709 FBgn0027151 FBgn0036355 FBgn0052120
References ( 389 )
Generate a list of	All references relating to this gene ( 389 )
List References by type	Research paper  ( 300 ) Supplementary material  ( 11 ) Review  ( 11 ) Erratum  ( 1 ) Personal communication to FlyBase  ( 17 ) Abstract  ( 36 ) FlyBase analysis  ( 1 ) Stock list  ( 3 ) Book  ( 2 ) DNA/RNA sequence record  ( 1 ) Website  ( 1 ) Conference report  ( 1 ) Curated genome annotation  ( 2 ) Letter  ( 1 )
Recent research papers ( 53 )
	Avanesov et al., 2012, PLoS Genet. 8(2): e1002503 The Role of Glypicans in Wnt Inhibitory Factor-1 Activity and the Structural Basis of Wif1's Effects on Wnt and Hedgehog Signaling. [FBrf0217590] Clark et al., 2012, PLoS ONE 7(5): e37351 Relative Effectiveness of Mating Success and Sperm Competition at Eliminating Deleterious Mutations in Drosophila melanogaster. [FBrf0218477] Dornier et al., 2012, J. Cell Biol. 199(3): 481--496 TspanC8 tetraspanins regulate ADAM10/Kuzbanian trafficking and promote Notch activation in flies and mammals. [FBrf0219816] Giagtzoglou et al., 2012, J. Cell Biol. 196(1): 65--83 dEHBP1 Controls Exocytosis and Recycling of Delta During Asymmetric Divisions. [FBrf0217836] Gross et al., 2012, Nat. Cell Biol. 14(10): 1036--1045 Active Wnt proteins are secreted on exosomes. [FBrf0219521] Herr and Basler, 2012, Dev. Biol. 361(2): 392--402 Porcupine-mediated lipidation is required for Wnt recognition by Wls. [FBrf0217047] Ho and Agrawal, 2012, J. Evol. Biol. 25(12): 2537--2546 The effects of competition on the strength and softness of selection. [FBrf0220046] Hödl and Basler, 2012, Curr. Biol. 22(23): 2253--2257 Transcription in the Absence of Histone H3.2 and H3K4 Methylation. [FBrf0220201] Jusiak et al., 2012, PLoS ONE 7(12): e50776 MAPK target sites of eyes absent are not required for eye development or survival in Drosophila. [FBrf0220418] Kametaka et al., 2012, J. Cell Sci. 125(3): 634--648 AP-1 clathrin adaptor and CG8538/Aftiphilin are involved in Notch signaling during eye development in Drosophila melanogaster. [FBrf0217589] Lee and Fischer, 2012, PLoS ONE 7(9): e46357 Drosophila Tel2 Is Expressed as a Translational Fusion with EpsinR and Is a Regulator of Wingless Signaling. [FBrf0219532] Legent et al., 2012, Genetics 190(2): 601--616 A screen for x-linked mutations affecting Drosophila photoreceptor differentiation identifies casein kinase 1α as an essential negative regulator of wingless signaling. [FBrf0217484] Li-Kroeger et al., 2012, Development 139(9): 1611--1619 Integration of an abdominal Hox complex with Pax2 yields cell-specific EGF secretion from Drosophila sensory precursor cells. [FBrf0217994] Mavromatakis and Tomlinson, 2012, Proc. Natl. Acad. Sci. U.S.A. 109(10): 3844--3849 The role of the small GTPase Rap in Drosophila R7 photoreceptor specification. [FBrf0217658] Mukherjee et al., 2012, G3 (Bethesda) 2(1): 23--28 Genetic analysis of fibroblast growth factor signaling in the Drosophila eye. [FBrf0217664] Mulligan et al., 2012, Proc. Natl. Acad. Sci. U.S.A. 109(2): 370--377 Secreted Wingless-interacting molecule (Swim) promotes long-range signaling by maintaining Wingless solubility. [FBrf0217131] Nfonsam et al., 2012, PLoS ONE 7(8): e44583 Analysis of the Transcriptomes Downstream of Eyeless and the Hedgehog, Decapentaplegic and Notch Signaling Pathways in Drosophila melanogaster. [FBrf0219414] Plavicki et al., 2012, Proc. Natl. Acad. Sci. U.S.A. 109(5): 1578--1583 Homeobox gene distal-less is required for neuronal differentiation and neurite outgrowth in the Drosophila olfactory system. [FBrf0217395] Powell et al., 2012, Mol. Cell. Biol. 32(14): 2849--2860 The SUMO Pathway Promotes Basic Helix-Loop-Helix Proneural Factor Activity via a Direct Effect on the Zn Finger Protein Senseless. [FBrf0218761] Sharp and Agrawal, 2012, Proc. Natl. Acad. Sci. U.S.A. 109(16): 6142--6146 Evidence for elevated mutation rates in low-quality genotypes. [FBrf0218045] Sánchez-Hernández et al., 2012, Development 139(20): 3849--3858 The WIF domain of the human and Drosophila Wif-1 secreted factors confers specificity for Wnt or Hedgehog. [FBrf0219478] Wells and Johnston, 2012, Dev. Biol. 361(2): 263--276 Maintenance of imaginal disc plasticity and regenerative potential in Drosophila by p53. [FBrf0217050] Wu et al., 2012, FEBS Lett. 586(22): 4052--4060 Drosophila miR-5 suppresses Hedgehog signaling by directly targeting Smoothened. [FBrf0219894] Yu et al., 2012, genesis 50(5): 393--403 Identification of Bombyx atonal and functional comparison with the Drosophila atonal proneural factor in the developing fly eye. [FBrf0218282] Anderson et al., 2011, Development 138(10): 1957--1966 The enhancer of trithorax and polycomb gene Caf1/p55 is essential for cell survival and patterning in Drosophila development. [FBrf0213580] Becam et al., 2011, Development 138(17): 3781--3789 Notch-mediated repression of bantam miRNA contributes to boundary formation in the Drosophila wing. [FBrf0214603] Bhattacharya and Baker, 2011, Cell 147(4): 881--892 A Network of Broadly Expressed HLH Genes Regulates Tissue-Specific Cell Fates. [FBrf0216641] Buechling et al., 2011, EMBO Rep. 12(12): 1265--1272 p24 proteins are required for secretion of Wnt ligands. [FBrf0216831] Cachero et al., 2011, PLoS Biol. 9(1): e1000568 The gene regulatory cascade linking proneural specification with differentiation in Drosophila sensory neurons. [FBrf0212891] Djiane et al., 2011, J. Cell Biol. 192(1): 189--200 Su(dx) E3 ubiquitin ligase-dependent and -independent functions of Polychaetoid, the Drosophila ZO-1 homologue. [FBrf0212737] Duan et al., 2011, EMBO J. 30(15): 3120--3133 Insensitive is a corepressor for Suppressor of Hairless and regulates Notch signalling during neural development. [FBrf0214638] Eivers et al., 2011, Sci. Signal. 4(194): ra68 Phosphorylation of Mad Controls Competition Between Wingless and BMP Signaling. [FBrf0216411] Esteve et al., 2011, Nat. Neurosci. 14(5): 562--569 SFRPs act as negative modulators of ADAM10 to regulate retinal neurogenesis. [FBrf0213582] Fiedler et al., 2011, Proc. Natl. Acad. Sci. U.S.A. 108(5): 1937--1942 Dishevelled interacts with the DIX domain polymerization interface of Axin to interfere with its function in down-regulating {beta}-catenin. [FBrf0212953] Gasnereau et al., 2011, J. Biol. Chem. 286(50): 43324--43333 Identification of an endocytosis motif in an intracellular loop of wntless protein, essential for its recycling and the control of wnt protein signaling. [FBrf0216938] Gontang et al., 2011, Development 138(22): 4899--4909 The cytoskeletal regulator Genghis khan is required for columnar target specificity in the Drosophila visual system. [FBrf0216508] Harterink et al., 2011, Nat. Cell Biol. 13(8): 914--923 A SNX3-dependent retromer pathway mediates retrograde transport of the Wnt sorting receptor Wntless and is required for Wnt secretion. [FBrf0216275] Hartl et al., 2011, J. Neurosci. 31(44): 15660--15673 A New Prospero and microRNA-279 Pathway Restricts CO2 Receptor Neuron Formation. [FBrf0216631] Karim and Moore, 2011, J. Neurosci. 31(47): 17017--17027 Convergent local identity and topographic projection of sensory neurons. [FBrf0216770] Lubensky et al., 2011, Proc. Natl. Acad. Sci. U.S.A. 108(27): 11145--11150 A dynamical model of ommatidial crystal formation. [FBrf0214256] Mendoza-Topaz et al., 2011, Open Biol. 1(3): 110013 The Adenomatous polyposis coli tumour suppressor is essential for Axin complex assembly and function and opposes Axin's interaction with Dishevelled. [FBrf0218486] Nègre et al., 2011, Nature 471(7339): 527--531 A cis-regulatory map of the Drosophila genome. [FBrf0213303] Olson et al., 2011, EMBO Rep. 12(10): 1047--1054 Yan, an ETS-domain transcription factor, negatively modulates the Wingless pathway in the Drosophila eye. [FBrf0216277] Pappu et al., 2011, Proc. Natl. Acad. Sci. U.S.A. 108(18): 7571--7576 Robo-3-mediated repulsive interactions guide R8 axons during Drosophila visual system development. [FBrf0213605] Popova et al., 2011, J. Cell Sci. 124(24): 4203--4212 Rb deficiency during Drosophila eye development deregulates EMC, causing defects in the development of photoreceptors and cone cells. [FBrf0217175] Quijano et al., 2011, Genetics 189(3): 809--824 Wg Signaling via Zw3 and Mad Restricts Self-Renewal of Sensory Organ Precursor Cells in Drosophila. [FBrf0216675] Rebeiz et al., 2011, Development 138(2): 215--225 Notch regulates numb: integration of conditional and autonomous cell fate specification. [FBrf0212636] Stephan et al., 2011, Mol. Biol. Cell 22(21): 4079--4092 Membrane-targeted WAVE mediates photoreceptor axon targeting in the absence of the WAVE complex in Drosophila. [FBrf0216499] Valenta et al., 2011, Genes Dev. 25(24): 2631--2643 Probing transcription-specific outputs of β-catenin in vivo. [FBrf0219193] Yanfeng et al., 2011, Dev. Biol. 360(1): 132--142 Functional dissection of phosphorylation of Disheveled in Drosophila. [FBrf0216602] You et al., 2011, Dev. Dyn. 240(3): 640--648 Sulfated is a negative feedback regulator of wingless in Drosophila. [FBrf0213052] Zhang et al., 2011, Cell Res. 21(12): 1677--1690 SNX3 controls Wingless/Wnt secretion through regulating retromer-dependent recycling of Wntless. [FBrf0216871] Zhu, 2011, J. Theor. Biol. 268(1): 131--140 Spatiotemporally modulated Vestigial gradient by Wingless signaling adaptively regulates cell division for precise wing size control. [FBrf0212388] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2011 Show reviews ...