FB2019_05, released Oct 15, 2019

Gene: Dmel\sens

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General Information
Symbol
Dmel\sens
Species
D. melanogaster
Name
senseless
Annotation Symbol
CG32120
Feature Type
protein_coding_gene
FlyBase ID
FBgn0002573
Gene Model Status
Current
Stock Availability
54 publicly available
Gene Snapshot
senseless (sens) encodes a transcription factor that stimulates expression of proneural gene expression. It regulates differentiation of the peripheral nervous system and the R8 photoreceptor. [Date last reviewed: 2019-03-14]
Other Summaries
Also Known As
Ly, Sensless, sense, sen
Key Links
Genomic Location
Cytogenetic map
70A8-70A8
Sequence location
3L:13,396,228..13,401,125 [-]
Recombination map
3-40
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
GO Summary Ribbons
Gene Group (FlyBase)
Protein Family (UniProt)
-
Protein Signatures (InterPro)
Molecular Function (GO)
[Detailed GO annotations]
Experimental Evidence
bHLH transcription factor binding; contributes_to DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor activity, RNA polymerase II-specific; sequence-specific DNA binding
Predictions / Assertions
-
Summaries
Gene Group (FlyBase)
C2H2 ZINC FINGER TRANSCRIPTION FACTORS -
Zinc finger C2H2 transcription factors are sequence-specific DNA binding proteins that regulate transcription. They possess DNA-binding domains that are formed from repeated Cys2His2 zinc finger motifs. (Adapted from PMID:1835093, FBrf0220103 and FBrf0155739).
Protein Function (UniProtKB)
Transcription factor both necessary and sufficient for proper development of most cell types of the embryonic and adult peripheral nervous system (PNS). Essential component of the proneural Notch signaling pathway required for proper sensory organ precursor (SOP) differentiation. Correct expression requires expression of scalloped (sd). Repression of rough (ro) in R8 photoreceptor is an essential mechanism of R8 cell fate determination.
(UniProt, Q9N658)
Phenotypic Description (Red Book; Lindsley and Zimm 1992)
Ly: Lyra
thumb
Ly: Lyra
From Bridges and Brehme, 1944, Carnegie Inst. Washington Publ. No. 552: 118.
Lateral margins of wings excised, giving narrowed shape; angle between veins L2 and L5 reduced. Bristles shortened and stubby; postscutellars frequently missing. Eyes somewhat deformed with tufted vibrissae. Abdomen dark and narrow with rear edge of tergites raised. Homozygous lethal. Ly/Df(3L)M69E is lethal. Modification of wings first visible as marginal scalloping of prepupal wing buds; wing fold narrower (Waddington, 1939, Proc. Nat. Acad. Sci. USA 25: 304; 1940, J. Genet. 41: 75-139). RK1A.
Summary (Interactive Fly)
zinc finger - target of proneural genes - expressed and required in sensory organ precursors for proper proneural gene expression - regulates differentiation the R8 photoreceptor - blocks nuclear transduction of Egfr activation through transcriptional repression of
Gene Model and Products
Number of Transcripts
1
Number of Unique Polypeptides
1

Please see the GBrowse view of Dmel\sens or the JBrowse view of Dmel\sens for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model
Low-frequency RNA-Seq exon junction(s) not annotated.
Gene model reviewed during 5.46
Sequence Ontology: Class of Gene
nuclear_gene
protein_coding_gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
sens-RA
FBtr0075862
NM_080079
2451
541
Additional Transcript Data and Comments
Reported size (kB)
2.8 (northern blot)
(Nolo et al., 2000)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
sens-PA
FBpp0075596
61.3
541
8.60
NP_524818
AAN11834
Polypeptides with Identical Sequences

There is only one protein coding transcript and one polypeptide associated with this gene

Additional Polypeptide Data and Comments
Reported size (kDa)
541 (aa)
(Nolo et al., 2000)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\sens using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Gene Ontology (17 terms)
Molecular Function (4 terms)
Terms Based on Experimental Evidence (4 terms)
CV Term
Evidence
References
bHLH transcription factor binding
inferred from direct assay
(Acar et al., 2006)
contributes_to DNA-binding transcription activator activity, RNA polymerase II-specific
inferred from direct assay
(McDonald et al., 2010)
DNA-binding transcription factor activity, RNA polymerase II-specific
inferred from direct assay
(Li-Kroeger et al., 2008)
sequence-specific DNA binding
inferred from direct assay
(Li-Kroeger et al., 2008)
Terms Based on Predictions or Assertions (0 terms)
Biological Process (11 terms)
Terms Based on Experimental Evidence (11 terms)
CV Term
Evidence
References
axon guidance
inferred from mutant phenotype
(Morey et al., 2008)
chaeta morphogenesis
inferred from mutant phenotype
(Wildonger and Mann, 2005)
compound eye photoreceptor development
inferred from mutant phenotype
(Frankfort and Mardon, 2004)
negative regulation of apoptotic process
inferred from mutant phenotype
(Mishra et al., 2013, Sprecher and Desplan, 2008)
negative regulation of transcription by RNA polymerase II
inferred from direct assay
(Li-Kroeger et al., 2008)
peripheral nervous system development
inferred from mutant phenotype
(Nolo et al., 2000)
photoreceptor cell differentiation
inferred from mutant phenotype
(Mishra et al., 2013)
photoreceptor cell morphogenesis
inferred from mutant phenotype
(Frankfort et al., 2001)
inferred from genetic interaction with FLYBASE:ro; FB:FBgn0003267
(Frankfort et al., 2001)
positive regulation of rhodopsin gene expression
inferred from mutant phenotype
(Mishra et al., 2013)
sensory organ development
inferred from mutant phenotype
(Acar et al., 2006, Jafar-Nejad et al., 2006)
inferred from genetic interaction with FLYBASE:sc; FB:FBgn0004170
(Jafar-Nejad et al., 2006)
inferred from genetic interaction with FLYBASE:da; FB:FBgn0267821
(Jafar-Nejad et al., 2006)
sensory organ precursor cell fate determination
inferred from mutant phenotype
(Jafar-Nejad et al., 2006)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
peripheral nervous system development
traceable author statement
(Salzberg et al., 1994)
sensory organ development
traceable author statement
(Treisman, 2004)
Cellular Component (2 terms)
Terms Based on Experimental Evidence (2 terms)
CV Term
Evidence
References
nucleus
inferred from direct assay
(Li-Kroeger et al., 2008, Tomasi et al., 2008)
polytene chromosome
inferred from direct assay
(Fox et al., 2013)
Terms Based on Predictions or Assertions (0 terms)
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 9 -- 10
antennal primordium
(Fisher et al., 2012)
clypeo-labral primordium
(Fisher et al., 2012)
dorsal ectoderm
(Fisher et al., 2012)
embryonic stage 10
lateral ectoderm | restricted
(Nolo et al., 2000)
embryonic stage 10 -- 12
presumptive embryonic/larval peripheral nervous system | restricted
(Nolo et al., 2000)
sensory mother cell
(Nolo et al., 2000)
embryonic stage 10 -- 17
external sensory organ precursor cell
(Tsuda et al., 2005)
embryonic stage 11 -- 12
external sensory organ precursor cell IIa
(Nolo et al., 2000)
external sensory organ precursor cell I
(Nolo et al., 2000)
external sensory organ precursor cell IIb
(Nolo et al., 2000)
antennal primordium
(Fisher et al., 2012)
Bolwig organ primordium

Comment: reported as larval eye primordium

(Fisher et al., 2012)
dorsal sensory complex primordium
(Fisher et al., 2012)
hypopharyngeal sense organ primordium
(Fisher et al., 2012)
labial sensory complex primordium
(Fisher et al., 2012)
labral sensory complex primordium
(Fisher et al., 2012)
maxillary sensory complex primordium
(Fisher et al., 2012)
salivary gland body primordium

Comment: reported as salivary gland primordium

(Fisher et al., 2012)
ventral sensory complex anlage
(Fisher et al., 2012)
embryonic stage 11 -- 13
salivary gland
(Nolo et al., 2000)
embryonic stage 11 -- 17
embryonic primordium of adult salivary gland
(Chandrasekaran and Beckendorf, 2003)
embryonic stage 13 -- 16
Bolwig organ
(Fisher et al., 2012)
dorsal sensory complex proper primordium

Comment: reported as dorsal/lateral sensory complexes

(Fisher et al., 2012)
embryonic antennal sense organ
(Fisher et al., 2012)
embryonic labial sensory complex
(Fisher et al., 2012)
embryonic maxillary sensory complex
(Fisher et al., 2012)
embryonic/larval salivary gland
(Fisher et al., 2012)
hypopharyngeal organ
(Fisher et al., 2012)
labral sensory complex
(Fisher et al., 2012)
ventral sensory complex primordium
(Fisher et al., 2012)
Additional Descriptive Data
Ly transcript is expressed in sensory organ precursors. Expression is first detected in stage 10 embryos in 2-4 cell ectodermal clusters. Expression quickly refines to the ectodermal cells giving rise to a subset of SOP cells. During stage 11, expression accumulates in SOPI and SOPII cells, with high expression in SOPI cells and low expression in the progeny of SOPII cells. Ly mRNA disappears during germ band retraction, and by stage 13, expression is only detected in the salivary glands.
(Nolo et al., 2000)
Marker for
 
external sensory organ precursor cell
(Tsuda et al., 2005)
Subcellular Localization
CV Term
Polypeptide Expression
distribution deduced from reporter
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 9 -- 12
C1 chordotonal organ precursor cell
(Witt et al., 2010)
third instar larval stage
eye disc | restricted
(Fu and Baker, 2003)
immunolocalization
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 10 -- 14
presumptive embryonic/larval peripheral nervous system | restricted
(Nolo et al., 2000)
sensory mother cell
(Nolo et al., 2000)
embryonic stage 10 -- 15
external sensory organ precursor cell
(Li-Kroeger et al., 2012)
embryonic stage 11
sensory organ cell
(Orgogozo et al., 2004)
antennal primordium | restricted
(Plavicki et al., 2012)
maxillary sensory complex primordium | restricted
(Plavicki et al., 2012)
embryonic antennal segment
(Plavicki et al., 2012)
embryonic mandibular segment
(Plavicki et al., 2012)
embryonic maxillary segment
(Plavicki et al., 2012)
embryonic labial segment
(Plavicki et al., 2012)
embryonic stage 11 -- 12
Bolwig organ primordium
(Mishra et al., 2013)
embryonic stage 11 -- 14
salivary gland
(Nolo et al., 2000)
embryonic stage 11 -- 17
embryonic primordium of adult salivary gland
(Chandrasekaran and Beckendorf, 2003)
embryonic stage 13
embryonic antennal segment | restricted
(Plavicki et al., 2016)
embryonic maxillary segment | restricted
(Plavicki et al., 2016)
embryonic labial segment | restricted
(Plavicki et al., 2016)
embryonic thoracic segment | restricted
(Plavicki et al., 2016)
larval stage
external sensory organ precursor cell of macrochaeta
(Al-Ramahi et al., 2007)
external sensory organ precursor cell of wing margin bristle
(Al-Ramahi et al., 2007)
wing disc
(Al-Ramahi et al., 2007)
third instar larval stage
metathoracic femoral chordotonal organ
(Nolo et al., 2000)
mesothoracic femoral chordotonal organ
(Nolo et al., 2000)
eye-antennal disc | restricted
(Nolo et al., 2000)
wing disc | restricted
(Nolo et al., 2000)
Johnston organ
(Nolo et al., 2000)
photoreceptor cell R8
(Fu and Baker, 2003, Nolo et al., 2000)
sensory mother cell
(Nolo et al., 2000)
prothoracic femoral chordotonal organ
(Nolo et al., 2000)
photoreceptor cell R8
• nucleus
(Tomasi et al., 2008)
dorsal-ventral compartment boundary of the wing disc
(Yan et al., 2009)
photoreceptor R8 precursor cell
(Kulkarni et al., 2016, Kinel-Tahan et al., 2007)
dorsal-ventral compartment boundary of the wing disc | surrounding
(Gao et al., 2013)
eye disc anterior to the morphogenetic furrow
(Gavish et al., 2016)
third instar larval stage -- adult stage
photoreceptor cell R7 | subset
(Domingos et al., 2004)
early third instar larval stage
triple row
(Mirth et al., 2009)
dorsocentral bristle precursor cell
(Mirth et al., 2009)
chordotonal organ of wing
(Mirth et al., 2009)
external sensory organ precursor cell of wing disc
(Mirth et al., 2009)
external sensory organ precursor cell of mesothoracic tergum
(Mirth et al., 2009)
adult stage
photoreceptor cell R8

Comment: not in dorsal margin photoreceptor R8

(Wernet et al., 2003)
Additional Descriptive Data
sens is specifically expressed in all primary photoreceptor neuron precursors (Bolwig organ primordium) in a short highly dynamic pulse during embryonic stages 11 and 12. Expression is initiated first in two primary precursors at mid stage 11, and is subsequently upregulated in the remaining two primary precursors. Expression of sens ceases during mid-late stage 12, when they start to express salm, and is then maintained until their maturation into fully differentiated Rh5-positive photoreceptors. By stage 15, no sens staining can be seen in salm-positive photoreceptors.
(Mishra et al., 2013)
ato and sens are detected in sensory precursor cells earlier than the rho reporter. All three are co-expressed in SOP cells of slightly older embryos. sens expression begins to fade in the C1 SOP cell lineage in stage 12.
(Witt et al., 2010)
sens is first detected at 15 hours after the second to third instar larval transition where it is observed in a single bristle sensory organ precursor (SOP) in the notum. At 20 hours it is expressed in the SOP of the wing hinge chordotonal organ and in a few more bristle SOPs in the wing and notal regions. By 30 hours it is upregulated in two stripes of triple-row SOPs at the wing margin and in a number of newly differentiated bristle SOPs in the wing and notum.
(Mirth et al., 2009)
sens is a predominantly nuclear protein. The only reported exception is in the wing disc, in the ectodermal cells surrounding the presumptive SOPs, where expression is not confined to the nuclei.
(Al-Ramahi et al., 2007, Nolo et al., 2000)
sens is a nuclear protein whose expression is limited to precursors and early differentiating cells of the PNS. sens protein and transcript expression patterns are similar. Expression is mainly detected in proneural fields of some SOPs, nuclei of SOPs, and differentiating cells of the PNS. sens protein is first detected at stage 10, peaks at stages 11 and 12, and starts disappearing by stage 13. Expression was also studied in imaginal discs. sens protein is expressed in eye-antennal discs in the R8 photoreceptors, two clusters of cells in the lateral portion of the disc, and the chordotonal organs of Johnston organs. In leg discs, expression is detected in the femoral chordotonal organ, and other external sensory SOPs. In wing discs, sens expression is dynamic, with expression first detected in ectodermal cells surrounding presumptive SOPs. The presumptive SOPs subsequently accumulate higher levels of sens protein. Comparison of sens and E(spl) protein expression in wild-type discs indicates that the expression of the two proteins do not overlap significantly.
(Nolo et al., 2000)
Marker for
 
photoreceptor R8 precursor cell
(Kinel-Tahan et al., 2007)
photoreceptor cell R7
(Domingos et al., 2004)
photoreceptor cell R8
(Zhang et al., 2016, Vrailas and Moses, 2006)
sensory organ cell
(Orgogozo et al., 2004)
Subcellular Localization
CV Term
Evidence
References
nucleus
inferred from direct assay
(Li-Kroeger et al., 2008, Tomasi et al., 2008)
polytene chromosome
inferred from direct assay
(Fox et al., 2013)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\sens in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
Flygut - An atlas of the Drosophila adult midgut
Images
FlyBase Wiki
Image Based Resources
Alleles, Insertions, and Transgenic Constructs
Classical and Insertion Alleles ( 22 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 31 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of sens
Transgenic constructs containing regulatory region of sens
Deletions and Duplications ( 9 )
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
lethal
lethal | recessive
lethal - all die before end of pupal stage, with Scer\GAL4pnr-MD237
Other Phenotypes
Allele
increased cell death
increased cell death | embryonic stage
neuroanatomy defective
some die during pupal stage, with Scer\GAL4pnr-MD237
visible
visible, with Scer\GAL4bbg-C96
visible, with Scer\GAL4Bx-MS1096
visible, with Scer\GAL4C1003
visible, with Scer\GAL4dpp.blk1
visible, with Scer\GAL4Eq1
visible, with Scer\GAL4lz-gal4
visible, with Scer\GAL4sca-109-68
visible, with Scer\GAL4vg.PU
visible (with sensLy-1)
visible (with sensSX67)
visible | cell autonomous | recessive | somatic clone
visible | dominant
visible | somatic clone
wild-type
Phenotype manifest in
Allele
abdominal dorsal multidendritic neuron ddaE & dendrite
anterior wing margin
axon & photoreceptor cell R7 | somatic clone, with Scer\GAL4Tub.PU
chaeta | cell autonomous | somatic clone
chaeta | ectopic, with Scer\GAL4Eq1
chaeta | ectopic, with Scer\GAL4vg.PU
chaeta | somatic clone
chordotonal organ
dorsal multidendritic neuron ddaE & dendrite
dorsal row | somatic clone
embryonic/larval oenocyte precursor
embryonic/larval salivary gland
embryonic/larval salivary gland | embryonic stage
embryonic peripheral nervous system & neuron (with Df(3L)S122804)
eo neuron | somatic clone | supernumerary
external sensory organ
external sensory organ (with Df(3L)S122804)
external sensory organ precursor cell IIa | somatic clone
external sensory organ precursor cell IIb | somatic clone | supernumerary
eye
eye, with Scer\GAL4lz-gal4
eyelet photoreceptor, with Scer\GAL4GMR.long
interommatidial bristle | ectopic, with Scer\GAL4lz-gal4
leg & chaeta, with Scer\GAL4dpp.blk1
leg | distal, with Scer\GAL4dpp.blk1
leg sensillum, with Scer\GAL4dpp.blk1
macrochaeta | ectopic, with Scer\GAL4dpp.blk1
macrochaeta | ectopic, with Scer\GAL4sca-109-68
macrochaeta | ectopic, with Scer\GAL4sca-537.4
mechanosensory chaeta | somatic clone
mechanosensory sensory organ | supernumerary, with Scer\GAL4sca-537.4
medulla | somatic clone, with Scer\GAL4sca-109-68, sensE2
medulla | somatic clone, with Scer\GAL4sca-109-68, sensUAS.cNa
mesothoracic bristle | ectopic, with Scer\GAL4dpp.blk1
mesothoracic bristle | ectopic, with Scer\GAL4Eq1
metathoracic bristle | ectopic, with Scer\GAL4Eq1
microchaeta & scutellum | ectopic, with Scer\GAL4cv-c-C5
microchaeta | cell autonomous | somatic clone
microchaeta | ectopic, with Scer\GAL4sca-109-68
microchaeta | ectopic, with Scer\GAL4sca-537.4
multidendritic neuron
ommatidium, with Scer\GAL4lz-gal4
ommatidium | somatic clone, with Scer\GAL4elav-C155
ommatidium | somatic clone (with sensE1)
ommatidium | somatic clone (with sensE2)
photoreceptor cell R2 | somatic clone
photoreceptor cell R5 | somatic clone
photoreceptor cell R7 | somatic clone (with sensE1)
photoreceptor cell R7 | somatic clone (with sensE2)
photoreceptor cell R8 | cell non-autonomous | somatic clone (with sensE1)
photoreceptor cell R8 | cell non-autonomous | somatic clone (with sensE2)
photoreceptor cell R8 | somatic clone
photoreceptor cell R8 | somatic clone (with sensE1)
photoreceptor cell R8 | somatic clone (with sensE2)
PNS glial cell (with Df(3L)S122804)
posterior wing margin
postorbital bristle | somatic clone
presumptive embryonic/larval peripheral nervous system (with Df(3L)S122804)
prothoracic tarsal bristle | ectopic, with Scer\GAL4Eq1
Rh5 photoreceptor of Bolwig organ | ectopic
Rh6 photoreceptor of Bolwig organ
scutellar bristle, with sensE1
scutellar bristle, with sensm1
scutellar bristle, with sensm1m2
scutellar bristle | ectopic, with Scer\GAL4sca-109-68
scutum, with Scer\GAL4dpp.blk1
scutum & chaeta, with Scer\GAL4dpp.blk1
secondary pigment cell, with Scer\GAL4lz-gal4
sensillum campaniformium of dorsal radius, with Scer\GAL4dpp.blk1
sensillum campaniformium of dorsal radius | supernumerary, with Scer\GAL4sca-109-68
sternopleural bristle, with Scer\GAL4dpp.blk1
tertiary pigment cell, with Scer\GAL4lz-gal4
thecogen cell (with Df(3L)S122804)
thecogen cell | somatic clone
tormogen cell | cell autonomous | somatic clone
tormogen cell | somatic clone
trichogen cell | somatic clone
trichome of the posterior wing margin | somatic clone
ventral row | somatic clone
wing
wing, with Scer\GAL4Bx-MS1096
wing, with Scer\GAL4dpp.blk1
wing & chaeta, with Scer\GAL4dpp.blk1
wing margin, with Scer\GAL4bbg-C96
wing margin, with Scer\GAL4C1003
wing margin, with Scer\GAL4dpp.blk1
wing margin (with sensLy-1)
wing margin (with sensSX67)
wing sensillum, with Scer\GAL4dpp.blk1
wing sensillum | ectopic, with Scer\GAL4dpp.blk1
Orthologs
Downloads
Download All DIOPT Orthologs
Download All OrthoDB Orthologs
Human Orthologs (via DIOPT v7.1)
Homo sapiens (Human) (3)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Hsap\GFI1B
3 of 15
No
Yes
 
Hsap\GFI1
1 of 15
No
No
 
Hsap\ZNF746
1 of 15
No
Yes
Model Organism Orthologs (via DIOPT v7.1)
Mus musculus (laboratory mouse) (3)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Mmus\Gfi1b
2 of 15
No
Yes
Mmus\Gfi1
1 of 15
No
No
 
Mmus\Zfp746
1 of 15
No
Yes
Rattus norvegicus (Norway rat) (3)
Rnor\Gfi1b
2 of 13
Yes
No
Rnor\Gfi1
1 of 13
No
No
Rnor\Zfp746
1 of 13
No
Yes
Xenopus tropicalis (Western clawed frog) (1)
Xtro\gfi1b
1 of 12
Yes
No
Danio rerio (Zebrafish) (2)
Drer\gfi1b
2 of 15
Yes
No
Drer\gfi1aa
1 of 15
No
No
Caenorhabditis elegans (Nematode, roundworm) (2)
Cele\pag-3
5 of 15
Yes
Yes
Cele\B0310.2
1 of 15
No
Yes
Arabidopsis thaliana (thale-cress) (1)
Atha\AT3G29340
1 of 9
Yes
No
Saccharomyces cerevisiae (Brewer's yeast) (2)
Scer\ACE2
1 of 15
Yes
Yes
Scer\SWI5
1 of 15
Yes
No
Schizosaccharomyces pombe (Fission yeast) (0)
No records found.
Orthologs in Drosophila Species (via OrthoDB v9.1) ( EOG09190947 )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila melanogaster
fruit fly
Dmel\sens
Drosophila suzukii
Spotted wing Drosophila
Dsuz\DS10_00010530
Drosophila simulans
Dsim\GD12667
Drosophila sechellia
Dsec\GM24598
Drosophila erecta
Dere\GG13774
Drosophila yakuba
Dyak\GE20069
Drosophila ananassae
Dana\GF10411
Drosophila pseudoobscura pseudoobscura
Dpse\GA16696
Drosophila persimilis
Dper\GL15695
Drosophila willistoni
Dwil\GK12454
Drosophila virilis
Dvir\GJ11823
Drosophila mojavensis
Dmoj\GI13460
Drosophila grimshawi
Dgri\GH16734
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG0915075P )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Mdoa\17022254
Musca domestica
House fly
Mdoa\17021250
Glossina morsitans
Tsetse fly
Gmor\GMOY011283
Glossina morsitans
Tsetse fly
Gmor\GMOY000179
Lucilia cuprina
Australian sheep blowfly
Lcup\FF38_10848
Lucilia cuprina
Australian sheep blowfly
Lcup\FF38_02920
Mayetiola destructor
Hessian fly
Mdes\Mdes009637
Aedes aegypti
Yellow fever mosquito
Aaeg\AAEL001243
Anopheles gambiae
Malaria mosquito
Agam\AGAP009699
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ002497
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ012536
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W06KT )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Bombyx mori
Silkmoth
Bmor\BGIBMGA003190
Bombyx mori
Silkmoth
Bmor\BGIBMGA006132
Danaus plexippus
Monarch butterfly
Dple\DPOGS211808-PA
Danaus plexippus
Monarch butterfly
Dple\DPOGS211207-PA
Heliconius melpomene
Postman butterfly
Hmel\HMEL012459
Heliconius melpomene
Postman butterfly
Hmel\HMEL002740
Apis florea
Little honeybee
Aflo\5779756916
Apis florea
Little honeybee
Aflo\2147668019
Apis mellifera
Western honey bee
Amel\Ame.2444
Apis mellifera
Western honey bee
Amel\GB45532
Apis mellifera
Western honey bee
Amel\GB40142
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP14814
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP24344
Bombus terrestris
Buff-tailed bumblebee
Bter\15204442
Bombus terrestris
Buff-tailed bumblebee
Bter\15205151
Linepithema humile
Argentine ant
Lhum\LH22736
Linepithema humile
Argentine ant
Lhum\LH22732
Linepithema humile
Argentine ant
Lhum\LH22733
Linepithema humile
Argentine ant
Lhum\LH22731
Linepithema humile
Argentine ant
Lhum\LH22063
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:00178e
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:000d2a
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG012936
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG006344
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG012937
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_04049
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_07154
Tribolium castaneum
Red flour beetle
Tcas\sens
Tribolium castaneum
Red flour beetle
Tcas\TC031695
Pediculus humanus
Human body louse
Phum\PHUM248190
Pediculus humanus
Human body louse
Phum\PHUM248200
Rhodnius prolixus
Kissing bug
Rpro\RPRC005969
Rhodnius prolixus
Kissing bug
Rpro\RPRC002026
Cimex lectularius
Bed bug
Clec\CLEC007060
Cimex lectularius
Bed bug
Clec\CLEC007062
Cimex lectularius
Bed bug
Clec\CLEC007061
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI008148
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI001809
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_03531
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X0ELG )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strigamia maritima
European centipede
Smar\SMAR005595
Strigamia maritima
European centipede
Smar\SMAR005599
Strigamia maritima
European centipede
Smar\SMAR014254
Strigamia maritima
European centipede
Smar\SMAR005594
Ixodes scapularis
Black-legged tick
Isca\ISCW020916
Ixodes scapularis
Black-legged tick
Isca\ISCW001542
Stegodyphus mimosarum
African social velvet spider
Smim\KFM69326.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM78965.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM69324.1
Tetranychus urticae
Two-spotted spider mite
Turt\tetur01g07180
Tetranychus urticae
Two-spotted spider mite
Turt\tetur16g01570
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_113215
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_113216
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G0NDD )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Z166
Ciona intestinalis
Vase tunicate
Cint\ENSCING00000011342
Gallus gallus
Domestic chicken
Ggal\GFI1
Gallus gallus
Domestic chicken
Ggal\GFI1B
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v7.1)
Drosophila melanogaster (Fruit fly) (30)
Gene Symbol
Score
Source
Compara
eggNOG
Homologene
Inparanoid
Isobase
OrthoDB
OrthoFinder
orthoMCL
Panther
RoundUp
Alignment
sens-2
3 of 10
Kr
2 of 10
Aef1
1 of 10
CG2129
1 of 10
CG3407
1 of 10
CG4318
1 of 10
CG6654
1 of 10
CG8319
1 of 10
CG8944
1 of 10
CG10147
1 of 10
CG10631
1 of 10
CG11695
1 of 10
CG11696
1 of 10
CG11902
1 of 10
CG12391
1 of 10
CG14655
1 of 10
CG15436
1 of 10
CG17359
1 of 10
CG17568
1 of 10
CG17612
1 of 10
CG18262
1 of 10
CG31388
1 of 10
CG33213
1 of 10
CTCF
1 of 10
erm
1 of 10
Kr-h1
1 of 10
pita
1 of 10
su(Hw)
1 of 10
topi
1 of 10
Zif
1 of 10
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Model Summary Ribbon
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 1 )
    Modifiers Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Interaction
    References
    Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
     
    Disease Associations of Human Orthologs (via DIOPT v7.1 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    GFI1B; growth factor independent 1B transcriptional repressor
    3 of 15
    604383
     
    Functional Complementation Data
    Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
    Interactions
    Summary of Physical Interactions
    Summary of Genetic Interactions
    esyN Network Diagram
    esyN Network Key:
    Suppression
    Enhancement
    View in Interactions Browser
    Please look at the allele data for full details of the genetic interactions
    Starting gene(s)
    Interaction type
    Interacting gene(s)
    Reference
    sens
    enhanceable
    ac
    (Jafar-Nejad et al., 2003)
    sens
    suppressible
    Antp
    (Anderson et al., 2011)
    sens
    suppressible
    Caf1-55
    (Anderson et al., 2011, Pepple et al., 2007)
    sens
    enhanceable
    da
    (Jafar-Nejad et al., 2006)
    sens
    enhanceable
    Dl
    (Pepple et al., 2007)
    sens
    suppressible
    Dl
    (Pepple et al., 2007)
    sens
    enhanceable
    E(ls)1
    (Pepple et al., 2007)
    sens
    enhanceable
    E(ls)3
    (Pepple et al., 2007)
    sens
    suppressible
    E(spl)m8-HLH
    (Nolo et al., 2000)
    sens
    suppressible
    E(z)
    (Anderson et al., 2011)
    sens
    suppressible
    esc
    (Anderson et al., 2011)
    sens
    suppressible
    HDAC1
    (Anderson et al., 2011)
    sens
    suppressible
    hid
    (Chandrasekaran and Beckendorf, 2003)
    sens
    suppressible
    lilli
    (Pepple et al., 2007)
    sens
    suppressible
    mir-9a
    (Li et al., 2006)
    sens
    suppressible
    msk
    (Pepple et al., 2007)
    sens
    suppressible
    pb
    (Anderson et al., 2011)
    sens
    suppressible
    Pc
    (Anderson et al., 2011)
    sens
    suppressible
    ro
    (Frankfort et al., 2001)
    sens
    suppressible
    S(ls)1
    (Pepple et al., 2007)
    sens
    suppressible
    S(ls)5
    (Pepple et al., 2007)
    sens
    suppressible
    S(ls)6
    (Pepple et al., 2007)
    sens
    suppressible
    S(ls)7
    (Pepple et al., 2007)
    sens
    suppressible
    sd
    (Srivastava and Bell, 2003)
    sens
    enhanceable
    sd
    (Srivastava and Bell, 2003)
    sens
    enhanceable
    smt3
    (Powell et al., 2012)
    sens
    suppressible
    Su(z)12
    (Anderson et al., 2011)
    Starting gene(s)
    Interaction type
    Interacting gene(s)
    Reference
    ac
    enhanceable
    sens
    (Jafar-Nejad et al., 2003)
    Atx-1
    suppressible
    sens
    (Tsuda et al., 2005)
    da
    enhanceable
    sens
    (Jafar-Nejad et al., 2006)
    Egfr::tor
    suppressible
    sens
    (Frankfort and Mardon, 2004)
    Egfr
    suppressible
    sens
    (Frankfort and Mardon, 2004)
    mir-9a
    suppressible
    sens
    (Cassidy et al., 2013, Bejarano et al., 2010, Li et al., 2006)
    Nf-YC
    suppressible
    sens
    (Morey et al., 2008)
    nvy
    suppressible
    sens
    (Wildonger and Mann, 2005)
    Rbfox1
    suppressible
    sens
    (Shukla et al., 2017)
    ru|rho
    enhanceable
    sens
    (Frankfort and Mardon, 2004)
    sc
    suppressible
    sens
    (Jafar-Nejad et al., 2006, Nolo et al., 2000)
    sc
    enhanceable
    sens
    (Cassidy et al., 2013, Jafar-Nejad et al., 2006)
    sd
    enhanceable
    sens
    (Srivastava and Bell, 2003)
    Snr1
    suppressible
    sens
    (Marenda et al., 2004)
    TBPH
    suppressible
    sens
    (Li et al., 2013)
    External Data
    Linkouts
    BioGRID - A database of protein and genetic interactions.
    DroID - A comprehensive database of gene and protein interactions.
    InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
    MIST (genetic) - An integrated Molecular Interaction Database
    MIST (protein-protein) - An integrated Molecular Interaction Database
    Pathways
    Gene Group - Pathway Membership (FlyBase)
    External Data
    Linkouts
    SignaLink - A signaling pathway resource with multi-layered regulatory networks.
    Genomic Location and Detailed Mapping Data
    Chromosome (arm)
    3L
    Recombination map
    3-40
    Cytogenetic map
    70A8-70A8
    Sequence location
    3L:13,396,228..13,401,125 [-]
    FlyBase Computed Cytological Location
    Cytogenetic map
    Evidence for location
    70A8-70A8
    Limits computationally determined from genome sequence between P{PZ}l(3)0422004220&P{lacW}l(3)j10B6j10B6 and P{PZ}stv00543
    Experimentally Determined Cytological Location
    Cytogenetic map
    Notes
    References
    70A-70A
    (Nolo, 1999.12.6)
    Experimentally Determined Recombination Data
    Location
    3-40
    (FlyBase, 2016)
    3-34.6
    (Comeron et al., 2012)
    3-41
    (Nolo et al., 2000)
    3-
    (Deak et al., 1997)
    3-40.5
    Left of (cM)
    Right of (cM)
    Notes
    On 3L.
    (Deak et al., 1997)
    Maps by recombination either to 3-23 or 3-41.7. The precise mapping position could not be determined because of chromosomal rearrangements.
    (Salzberg et al., 1994)
    Stocks and Reagents
    Stocks (54)
    Genomic Clones (14)
     

    Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

    cDNA Clones (5)
     

    Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

    cDNA clones, fully sequences
    BDGP DGC clones
    Other clones
      Drosophila Genomics Resource Center cDNA clones

      For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

      cDNA Clones, End Sequenced (ESTs)
      BDGP DGC clones
        Other clones
        RNAi and Array Information
        Linkouts
        DRSC - Results frm RNAi screens
        GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
        Antibody Information
        Laboratory Generated Antibodies
         
        polyclonal antibody
        (Domingos et al., 2004)
        Commercially Available Antibodies
         
        Other Information
        Relationship to Other Genes
        Source for database identify of
        Source for database merge of
        Source for merge of: sens CG10714
        (Bayraktaroglu, 2000.8.7)
        Source for merge of: Ly sens l(3)70Ad
        (Nolo et al., 2000)
        Additional comments
        The dominant phenotype associated with sensLy-1 cannot be recombined onto a "sens" mutant chromosome, indicating that both mutations map at the same site.
        (Nolo et al., 2000)
        Other Comments
        mir-9a minimises the phenotypic impact of genomic diversity on determination of sensory cell fate by buffering the level of sens protein.
        (Cassidy et al., 2013)
        DNA-protein interactions: genome-wide binding profile assayed for sens protein in 0-12 hr embryos; see mE1_TFBS_sens collection report.
        (Negre et al., 2011)
        sens physically interacts with sc, ato, ac, and da. The Zn-finger domains of sens mediate the interaction between sens and sc. Zn-finger 2 and 3 are indispensable for sens function.
        (Acar et al., 2006)
        sens plays a role in the development of all bristles but its role is different in subtypes of these organs. It is required for pI progeny fate specification in thoracic microchaetae, for pI selection and specification in wing margin chemoreceptors, and for proneural survival in wing margin mechanoreceptors.
        (Jafar-Nejad et al., 2006)
        dsRNA has been made from templates generated with primers directed against this gene. RNAi of sens causes extensive mixing of dendritic arbors from the ddaD and ddaE neurons, in addition to dorsal overextension of primary dendrites and an overall reduction in the number of class I da neurons. RNAi also causes alterations in the number of MD neurons, defects in dendrite morphogenesis and reproducible defects in da dendrite development.
        (Parrish et al., 2006)
        Residues 100-154, part of the AXH domain of Atx-1 are necessary and sufficient to allow a physical interaction with sens.
        (Tsuda et al., 2005)
        sens promotes normal R8 photoreceptor differentiation by preventing the effects of autocrine stimulation by spi, through transcriptional repression of pnt.
        (Frankfort and Mardon, 2004)
        sens repression of ro is required for R8 phototreceptor differentiation in the developing eye.
        (Frankfort et al., 2001)
        Proneural genes activate sens expression. sens is then required to further activate and maintain proneural gene expression.
        (Nolo et al., 2000)
        sens is both necessary and sufficient for peripheral nervous system development.
        (Nolo et al., 2000)
        Mutation in sens causes a loss of neurons.
        (Salzberg et al., 1994)
        sens is required for PNS development in the embryo.
        (Salzberg et al., 1994)
        A wing margin mutation that interacts additively with ct. sens causes tissue loss from the anterior and posterior wing margins. In double mutants of sens and ct46l and ct53d no part of the margin is lost that isn't lost in either of the mutants alone.
        (Jack and DeLotto, 1992)
        The components for positional information within the wing have been determined.
        (Abbott and Sprey, 1990)
        Origin and Etymology
        Discoverer
        Dubinin, 1929.
        Etymology
        Identification
        External Crossreferences and Linkouts ( 33 )
        Sequence Crossreferences
        NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
        GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
        GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
        RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
        UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
        Other crossreferences
        BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
        Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
        Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
        Flygut - An atlas of the Drosophila adult midgut
        GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
        iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
        InterPro - A database of protein families, domains and functional sites
        KEGG Genes - Molecular building blocks of life in the genomic space.
        modMine - A data warehouse for the modENCODE project
        SignaLink - A signaling pathway resource with multi-layered regulatory networks.
        Linkouts
        BioGRID - A database of protein and genetic interactions.
        DroID - A comprehensive database of gene and protein interactions.
        DRSC - Results frm RNAi screens
        FLIGHT - Cell culture data for RNAi and other high-throughput technologies
        FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
        FlyMine - An integrated database for Drosophila genomics
        Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
        InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
        MIST (genetic) - An integrated Molecular Interaction Database
        MIST (protein-protein) - An integrated Molecular Interaction Database
        Synonyms and Secondary IDs (19)
        Reported As
        Symbol Synonym
        1228/04
        (Deak et al., 1997)
        CG10714
        (Whitfield, 2000.11.22)
        CG32120
        (Hassan et al., 2018, Meadows, 2017.9.14, Guven-Ozkan et al., 2016, Aerts et al., 2010, Ni et al., 2010.12.1, Bossuyt et al., 2009, Keleman et al., 2009.8.5)
        Gfi1
        (Jukam et al., 2013)
        Ly
        (Clark et al., 2012, Laffafian et al., 2010, Wang et al., 2009, Sharp and Agrawal, 2008, Marenda et al., 2004, Nolo et al., 2001, Nolo et al., 2000, Abbott and Zidar, 1999, Szeged Stock Center, 1998-, Deak et al., 1997, Abbott, 1996, Sturtevant and Bier, 1995, Abbott, 1994, Carpenter, 1994, Garcia-Bellido and de Celis, 1992, Jack and DeLotto, 1992, Lindsley and Zimm, 1992, Abbott and Sprey, 1990, Sinclair et al., 1984, Zhimulev and Feldman, 1982, Waddle, 1977, Waddington, 1940, Waddington, 1939, Dunn and Mossige, 1937, Morgan et al., 1937, Coyne, 1935)
        Ly-1
        (Bloomington Drosophila Stock Center, 1999.7.3)
        SENS
        (Litovchenko and Laurent, 2016, Cheng et al., 2013, Bury et al., 2008)
        Sen
        (Goodman et al., 2006, Baeg et al., 2004)
        Sens
        (Bernascone et al., 2019, Chai et al., 2019, Duan et al., 2018, Li et al., 2018, Miller and Posakony, 2018, Costa et al., 2017, Koch et al., 2017, Szuplewski et al., 2017, van Tienen et al., 2017, Friedrich et al., 2016, Jin et al., 2016, Li et al., 2016, Lv et al., 2016, Matsumoto et al., 2016, Quan et al., 2016, Viets et al., 2016, Zhang et al., 2016, Balmer et al., 2015, Finley et al., 2015, Hall and Verheyen, 2015, Charng et al., 2014, Dewald et al., 2014, Huang et al., 2014, Marr et al., 2014, Oliveira et al., 2014, Schilling et al., 2014, Wernet et al., 2014, Zhang et al., 2014, Atkins et al., 2013, Giagtzoglou et al., 2013, Jauffred et al., 2013, Johnston, 2013, Mishra et al., 2013, Rister et al., 2013, Sasamura et al., 2013, Serysheva et al., 2013, Serysheva et al., 2013, Shwartz et al., 2013, Steinhauer et al., 2013, Strutt et al., 2013, Thanawala et al., 2013, van de Hoef et al., 2013, Avanesov et al., 2012, Dornier et al., 2012, Giagtzoglou et al., 2012, Gross et al., 2012, Hödl and Basler, 2012, Jusiak et al., 2012, Kametaka et al., 2012, Legent et al., 2012, Li-Kroeger et al., 2012, Liu et al., 2012, Mulligan et al., 2012, Nfonsam et al., 2012, Nose, 2012, Ruggiero et al., 2012, Sánchez-Hernández et al., 2012, Swarup and Verheyen, 2012, Wu et al., 2012, Zarifi et al., 2012, Becam et al., 2011, Buechling et al., 2011, Duan et al., 2011, Eivers et al., 2011, Esteve et al., 2011, Olson et al., 2011, Quijano et al., 2011, Rebeiz et al., 2011, Valenta et al., 2011, Yanfeng et al., 2011, You et al., 2011, Beam and Moberg, 2010, Egger-Adam and Katanaev, 2010, Gutzwiller et al., 2010, Hamel et al., 2010, Kleinschmit et al., 2010, McDonald et al., 2010, Mukai et al., 2010, Quijano et al., 2010, Roignant and Treisman, 2010, Yogev et al., 2010, zur Lage and Jarman, 2010, Andrews et al., 2009, Baker et al., 2009, Benítez et al., 2009, Bhattacharya and Baker, 2009, Bossuyt et al., 2009, Chanet et al., 2009, Gomes et al., 2009, Hödl and Basler, 2009, Kahali et al., 2009, Li et al., 2009, Mao and Freeman, 2009, Nagaraj and Banerjee, 2009, O'Keefe et al., 2009, Rajan et al., 2009, Steele et al., 2009, Yan et al., 2009, Chang et al., 2008, Chang et al., 2008, Chang et al., 2008, Deb et al., 2008, Duong et al., 2008, Gallet et al., 2008, Herranz et al., 2008, Kandachar et al., 2008, Katanaev et al., 2008, Mao et al., 2008, McNeill et al., 2008, Miller et al., 2008, Miura et al., 2008, Perdigoto et al., 2008, Tomasi et al., 2008, Weber et al., 2008, Wu et al., 2008, Buceta et al., 2007, Escudero et al., 2007, Guan et al., 2007, Silver et al., 2007, Smith et al., 2007, Tanaka-Matakatsu et al., 2007, Banziger et al., 2006, Bose et al., 2006, Fang et al., 2006, Herranz et al., 2006, Holohan et al., 2006, Hufnagel et al., 2006, Jaekel and Klein, 2006, Klein et al., 2006, Parrish et al., 2006, Rives et al., 2006, Roignant et al., 2006, Rusten et al., 2006, Seto and Bellen, 2006, Zhang et al., 2006, Gomes and Schweisguth, 2005, Mikeladze-Dvali et al., 2005, Pappu, 2005, Pappu et al., 2005, Rogers et al., 2005, Zhang et al., 2005, Quan et al., 2004, Parker et al., 2002)
        Senseless
        (Shukla et al., 2017)
        Ss
        (Balakireva et al., 2006)
        l(3)70Ad
        sen
        (Zhang et al., 2009, Zhang et al., 2006)
        sens
        (Neitzel et al., 2019, Ariss et al., 2018, Billmann et al., 2018, Hassan et al., 2018, Vuong et al., 2018, Wang and Baker, 2018, Shukla et al., 2017, Gavish et al., 2016, Guven-Ozkan et al., 2016, Mishra et al., 2016, Plavicki et al., 2016, Sarov et al., 2016, Seyres et al., 2016, Zhang et al., 2016, Zhang et al., 2016, Golubyatnikov et al., 2015, Jahr et al., 2015, Legent et al., 2015, Mencarelli and Pichaud, 2015, Nadimpalli et al., 2015, Schertel et al., 2015, Suh et al., 2015, Feng et al., 2014, Guo et al., 2014, Hsiao et al., 2014, Jiang and Singh, 2014, Kim et al., 2014, Marr et al., 2014, Miller et al., 2014, Vuong et al., 2014, Wang et al., 2014, Cassidy et al., 2013, Das et al., 2013, Doumpas et al., 2013, Enuameh et al., 2013, Fox et al., 2013, Gao et al., 2013, Jukam et al., 2013, Jukam et al., 2013, Li et al., 2013, Ou and Lei, 2013, Pancratov et al., 2013, Schertel et al., 2013, Webber et al., 2013, Herr and Basler, 2012, Japanese National Institute of Genetics, 2012.5.21, Lee and Fischer, 2012, Mavromatakis and Tomlinson, 2012, Plavicki et al., 2012, Powell et al., 2012, Spokony and White, 2012.5.22, Yu et al., 2012, Anderson et al., 2011, Bhattacharya and Baker, 2011, Cachero et al., 2011, Esteve et al., 2011, Fiedler et al., 2011, Gasnereau et al., 2011, Karim and Moore, 2011, Lubensky et al., 2011, Mendoza-Topaz et al., 2011, Nègre et al., 2011, Pappu et al., 2011, You et al., 2011, Zhang et al., 2011, Zhu, 2011, Aerts et al., 2010, Barad et al., 2010, Bejarano et al., 2010, Buechling et al., 2010, Buffin and Gho, 2010, de Navascués and Modolell, 2010, Hermle et al., 2010, Pennington and Lubensky, 2010, Sen et al., 2010, Song et al., 2010, The modENCODE Consortium, 2010, The modENCODE Consortium, 2010, Wang et al., 2010, Witt et al., 2010, Wu et al., 2010, Zhai et al., 2010, Aerts et al., 2009, Baena-Lopez et al., 2009, Bhattacharya and Baker, 2009, Biryukova et al., 2009, Choi et al., 2009, Perkins et al., 2009.8.10, Piddini and Vincent, 2009, Venken et al., 2009, Wu et al., 2009, Yan et al., 2009, Zhai et al., 2009, Asmar et al., 2008, Belenkaya et al., 2008, Christensen et al., 2008.9.29, Franch-Marro et al., 2008, Gebelein et al., 2008, Kennell et al., 2008, Li-Kroeger et al., 2008, Li-Kroeger et al., 2008, Mieszczanek et al., 2008, Morey et al., 2008, Morey et al., 2008, Pepple et al., 2008, Powell et al., 2008, Sprecher and Desplan, 2008, Tien et al., 2008, Xie et al., 2008, Zeng et al., 2008, Al-Ramahi et al., 2007, Ayyar et al., 2007, Cao et al., 2007, de la Roche and Bienz, 2007, Ebacher et al., 2007, Endo et al., 2007, Kinel-Tahan et al., 2007, Li et al., 2007, Loncle et al., 2007, Pepple et al., 2007, Tyler and Baker, 2007, Xie et al., 2007, Bartscherer et al., 2006, Janody and Treisman, 2006, Kent et al., 2006, Kuranaga et al., 2006, Li et al., 2006, Seto and Bellen, 2006, Venken, 2006, Venken et al., 2006, Xie and Cook, 2006, DasGupta et al., 2005, Hayward et al., 2005, Hoskins et al., 2005, Frankfort et al., 2004, Kreuger et al., 2004, zur Lage et al., 2004)
        sense
        (Baig-Lewis et al., 2007, Bateman and McNeill, 2004)
        senseless
        (Zhang et al., 2016, Slattery et al., 2014, Ruggiero et al., 2012)
        Name Synonyms
        Lyra
        Senseless
        (Costa et al., 2017, Yamaguchi et al., 2017, Zhang et al., 2016, Aparicio et al., 2015, Wernet et al., 2015, Alexandre et al., 2014, Dewald et al., 2014, Lin et al., 2014, Oliveira et al., 2014, Giagtzoglou et al., 2013, Jukam et al., 2013, Li et al., 2013, Li et al., 2013, Ruan et al., 2013, Shwartz et al., 2013, Steinhauer et al., 2013, van de Hoef et al., 2013, Avanesov et al., 2012, Dornier et al., 2012, Giagtzoglou et al., 2012, Kametaka et al., 2012, Mirth and Shingleton, 2012, Mukherjee et al., 2012, Nose, 2012, Ruggiero et al., 2012, Becam et al., 2011, Buechling et al., 2011, Djiane et al., 2011, Eivers et al., 2011, Gontang et al., 2011, Nègre et al., 2011, Pappu et al., 2011, Popova et al., 2011, Rebeiz et al., 2011, Stephan et al., 2011, Valenta et al., 2011, Yanfeng et al., 2011, Aerts et al., 2010, Beam and Moberg, 2010, Cohen et al., 2010, de Navascués and Modolell, 2010, Egger-Adam and Katanaev, 2010, Gutzwiller et al., 2010, Kleinschmit et al., 2010, McDonald et al., 2010, Mukai et al., 2010, Pennington and Lubensky, 2010, Roignant and Treisman, 2010, Singh et al., 2010, zur Lage and Jarman, 2010, Baker et al., 2009, Bhattacharya and Baker, 2009, Bossuyt et al., 2009, Gomes et al., 2009, Hödl and Basler, 2009, Li et al., 2009, Mao and Freeman, 2009, Mirth et al., 2009, O'Keefe et al., 2009, Steele et al., 2009, Stern et al., 2009, Asmar et al., 2008, Bray et al., 2008, Bury et al., 2008, Chang et al., 2008, Deb et al., 2008, Duong et al., 2008, Gebelein et al., 2008, Herranz et al., 2008, Kandachar et al., 2008, Li-Kroeger et al., 2008, Liu and Lehmann, 2008, Mao et al., 2008, Miller et al., 2008, Miura et al., 2008, Morey et al., 2008, Petrovic and Hummel, 2008, Sprecher and Desplan, 2008, Tomasi et al., 2008, Xie et al., 2008, Cao et al., 2007, Guan et al., 2007, Krisel and Moberg, 2007, Silver et al., 2007, Tanaka-Matakatsu et al., 2007, Tseng et al., 2007, Xie et al., 2007, Acar et al., 2006, Balakireva et al., 2006, Goodman et al., 2006, Herranz et al., 2006, Holohan et al., 2006, Hufnagel et al., 2006, Jafar-Nejad et al., 2006, Rusten et al., 2006, Shinza-Kameda et al., 2006, Strutt et al., 2006, Vrailas and Moses, 2006, Vrailas et al., 2006, David et al., 2005, Rodrigues et al., 2005, Rogers et al., 2005, Wei et al., 2005, Lin et al., 2002, Wang et al., 2002, Yang and Baker, 2001)
        Sensless
        (Ruggiero et al., 2012, Perdigoto et al., 2008, Bhambhani et al., 2007)
        senseless
        (Papadopoulos et al., 2019, Perry et al., 2017, Golubyatnikov et al., 2015, Kakugawa et al., 2015, Hsiao et al., 2014, Huang et al., 2014, Marr et al., 2014, Miller et al., 2014, Slattery et al., 2014, Wang et al., 2014, Doumpas et al., 2013, Li et al., 2013, Ou and Lei, 2013, Herr and Basler, 2012, Mavromatakis and Tomlinson, 2012, Plavicki et al., 2012, Bhattacharya and Baker, 2011, Fiedler et al., 2011, Harterink et al., 2011, Hartl et al., 2011, Mendoza-Topaz et al., 2011, Bejarano et al., 2010, Buffin and Gho, 2010, Mohan et al., 2010, Song et al., 2010, Wang et al., 2010, Witt et al., 2010, Zhai et al., 2010, Zimmerman et al., 2010, Aerts et al., 2009, Babaoglan et al., 2009, Baena-Lopez et al., 2009, Eivers et al., 2009, Song et al., 2009, Zhai et al., 2009, Zhang et al., 2009, Belenkaya et al., 2008, Franch-Marro et al., 2008, Kennell and Cadigan, 2008, Li-Kroeger et al., 2008, Pepple et al., 2008, Petrovic and Hummel, 2008, Wu et al., 2008, Al-Ramahi et al., 2007, Ayyar et al., 2007, Baig-Lewis et al., 2007, Buceta et al., 2007, de la Roche and Bienz, 2007, Ebacher et al., 2007, Kennell and Cadigan, 2007, Kinel-Tahan et al., 2007, Li et al., 2007, Loncle et al., 2007, Tyler and Baker, 2007, Bartscherer et al., 2006, Cohen et al., 2006, Xie and Cook, 2006, Zhang et al., 2006, Hayward et al., 2005, Jafar-Nejad and Bellen, 2004)
        sensesless
        (You et al., 2011)
        Secondary FlyBase IDs
        • FBgn0011709
        • FBgn0027151
        • FBgn0036355
        • FBgn0052120
        Datasets (1)
        Study focus (1)
        Experimental Role
        Project
        Project Type
        Title
        • transgene_used
        modENCODE_regulation_TFs
        Genome-wide localization of transcription factors by ChIP-chip and ChIP-Seq.
        References (528)