Ly, Sensless, sense, sen
zinc finger - target of proneural genes - expressed and required in sensory organ precursors for proper proneural gene expression - regulates differentiation the R8 photoreceptor - blocks nuclear transduction of Egfr activation through transcriptional repression of
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Low-frequency RNA-Seq exon junction(s) not annotated.
Gene model reviewed during 5.46
2.8 (northern blot)
There is only one protein coding transcript and one polypeptide associated with this gene
541 (aa)
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\sens using the Feature Mapper tool.
Comment: reported as larval eye primordium
Comment: reported as salivary gland primordium
Comment: reported as dorsal/lateral sensory complexes
sens transcript is expressed in sensory organ precursors. Expression is first detected in stage 10 embryos in 2-4 cell ectodermal clusters. Expression quickly refines to the ectodermal cells giving rise to a subset of SOP cells. During stage 11, expression accumulates in SOPI and SOPII cells, with high expression in SOPI cells and low expression in the progeny of SOPII cells. sens mRNA disappears during germ band retraction, and by stage 13, expression is only detected in the salivary glands.
Comment: not in dorsal margin photoreceptor R8
. The expression of sens at the posterior wing margin gradually declines from 6-8 h APF to 16-18 h APF, and is below detection at 20-22 h APF.
sens is specifically expressed in all primary photoreceptor neuron precursors (Bolwig organ primordium) in a short highly dynamic pulse during embryonic stages 11 and 12. Expression is initiated first in two primary precursors at mid stage 11, and is subsequently upregulated in the remaining two primary precursors. Expression of sens ceases during mid-late stage 12, when they start to express salm, and is then maintained until their maturation into fully differentiated Rh5-positive photoreceptors. By stage 15, no sens staining can be seen in salm-positive photoreceptors.
sens is first detected at 15 hours after the second to third instar larval transition where it is observed in a single bristle sensory organ precursor (SOP) in the notum. At 20 hours it is expressed in the SOP of the wing hinge chordotonal organ and in a few more bristle SOPs in the wing and notal regions. By 30 hours it is upregulated in two stripes of triple-row SOPs at the wing margin and in a number of newly differentiated bristle SOPs in the wing and notum.
sens is a predominantly nuclear protein. The only reported exception is in the wing disc, in the ectodermal cells surrounding the presumptive SOPs, where expression is not confined to the nuclei.
sens is a nuclear protein whose expression is limited to precursors and early differentiating cells of the PNS. sens protein and transcript expression patterns are similar. Expression is mainly detected in proneural fields of some SOPs, nuclei of SOPs, and differentiating cells of the PNS. sens protein is first detected at stage 10, peaks at stages 11 and 12, and starts disappearing by stage 13. Expression was also studied in imaginal discs. sens protein is expressed in eye-antennal discs in the R8 photoreceptors, two clusters of cells in the lateral portion of the disc, and the chordotonal organs of Johnston organs. In leg discs, expression is detected in the femoral chordotonal organ, and other external sensory SOPs. In wing discs, sens expression is dynamic, with expression first detected in ectodermal cells surrounding presumptive SOPs. The presumptive SOPs subsequently accumulate higher levels of sens protein. Comparison of sens and E(spl) protein expression in wild-type discs indicates that the expression of the two proteins do not overlap significantly.
Comment: 6hrs APF
Comment: 12hrs APF
Comment: 24hrs APF
GBrowse - Visual display of RNA-Seq signals
View Dmel\sens in GBrowse 23-40
3-40
3-34.6
3-41
3-40.5
On 3L.
Maps by recombination either to 3-23 or 3-41.7. The precise mapping position could not be determined because of chromosomal rearrangements.
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
polyclonal antibody
Source for merge of: sens CG10714
Source for merge of: Ly sens l(3)70Ad
The dominant phenotype associated with sensLy-1 cannot be recombined onto a "sens" mutant chromosome, indicating that both mutations map at the same site.
DNA-protein interactions: genome-wide binding profile assayed for sens protein in 0-12 hr embryos; see mE1_TFBS_sens collection report.
sens plays a role in the development of all bristles but its role is different in subtypes of these organs. It is required for pI progeny fate specification in thoracic microchaetae, for pI selection and specification in wing margin chemoreceptors, and for proneural survival in wing margin mechanoreceptors.
dsRNA has been made from templates generated with primers directed against this gene. RNAi of sens causes extensive mixing of dendritic arbors from the ddaD and ddaE neurons, in addition to dorsal overextension of primary dendrites and an overall reduction in the number of class I da neurons. RNAi also causes alterations in the number of MD neurons, defects in dendrite morphogenesis and reproducible defects in da dendrite development.
sens is both necessary and sufficient for peripheral nervous system development.
Mutation in sens causes a loss of neurons.
sens is required for PNS development in the embryo.
The components for positional information within the wing have been determined.
Dubinin, 1929.