Many alleles with a wide range of phenotypes.
Homozygous males have eyes size variably reduced and often
ovoid in shape. Surface with fused facets producing a
roughened glistening appearance (= glossy), or smooth with
pigment either uniformly distributed or concentrated at periphery of the eye (= spectacle). Eye pigment variably reduced,
and Malpighian tubes slightly lighter than normal (Brehme and
Demerec, 1942, Growth 6: 351-56). Tarsal claws reduced to
different extents by different alleles. Spermathecae and
parovaria (= accessory glands) often missing in homozygotes
with abnormal parovaria seen in some heterozygous females
(Anderson, 1945). Females often sterile, but sterility
appears to be primarily an ovarian defect, since some genotypes which lack parovaria and spermathecae are female fertile. Some alleles lack the class of hemocytes called crystal
cells, or at least lack the crystalline inclusions of those
cells; the inclusions can be shown to comprise prophenoloxidase, and flies lacking crystal cells are deficient in phenol
oxidase activity and suppress the phenotype of Bc. Five of
fifteen alleles tested (lz36f17, lz46, lzD, lzrfg, and lzs)
suppress Bc and lack crystal cells and phenol oxidase activity
(Rizki and Rizki, 1981, Genetics 97: s90); postulated that
lz+ crucial to differentiation of crystal cells, and is not a
structural gene for any of the five phenol oxidase moieties.
Peeples, Geisler, Whitcraft, and Oliver report defective
phenol oxidase activity in lzg (1969, Biochem. Genet.
3: 563-69) lz64j, lz66c, lzs, and lzy4, but not in lz50e, or
lzK (1969, Genetics 62: 161-70); Warner, Grell, and Jacobson
(1974, Biochem. Genet. 11: 359-65) found no phenol oxidase
activity in lzrfg, but normal levels in lz1 and lzg.
Eye narrower than wild type and ovoid. Irregular
facets in some areas cause rough patches; areas of fused
facets appear as smooth patches. Eye color appears normal
but, in combination with st, slight reduction in red pigment
detectable. Tarsal claws reduced. Developmental study by Waddington and Pilkington (1942, DIS 16: 70) shows failure of
middle cell layer of optic disk to penetrate between cells of
outer layer; surface thus covered with primary pigment cells.
Females sterile. Parovaria and spermathecae absent; some lz/+
females have abnormal parovaria (Anderson, 1945, Genetics
30: 280-96). Suppressed by su(f)6 (Schalet, 1970, Genen.
Phaenen 14: 16-17), su(Hw)2, e(we)s, and su(pr)e3; enhanced
by su(s)3 and su(wa) (Rutledge, Mortin, Schwarz, Thierry-Mieg,
and Meselson, 1988, Genetics 119: 391-97). Phenol oxidase
activity increased from 17% to 71% normal (Snyder and Smith,
1976, Biochem. Genet. 14: 611-17). RK1.
Eye size sharply reduced; surface smooth. Optic
disk of mature larva and prepupa two-thirds normal size (Chen,
1929, J. Morphol. 47: 135-99). Red pigment greatly reduced;
color yellowish brown, cream colored in combination with v.
Tarsal claws vestigial. Homozygous females lack parovaria and
spermathecae and are sterile; lz3/+ females lack parovaria and
many have abnormal spermathecae [Anderson, 1945, Genetics
30: 280-96 (fig.)]. Unaffected by su(f)6 (Schalet, Snyder,
and Smith, 1976, Biochem. Genet. 14: 611-17). RK1.
Eye phenotype intermediate between lz and lz3. Surface of eye has large areas of fused facets with a few normal
facets (Clayton, 1957, Genetics 42: 28-41); eye color dark
red with small yellowish spots. Larval Malpighian tubes
slightly lighter than normal; variable (Brehme and Demerec,
1942, Growth 6: 351-56). Tarsal claws reduced. Spermathecae
and parovaria absent from homozygous females, which accumulate
stage 14 oocyte and are quite infertile; some lz34/+ females
have abnormal parovaria (Anderson, 1945, Genetics 30: 280-96). Eye effect, but not other aspects of phenotype, enhanced
by spae(lz); eye converted from a glossy to a spectacle phenotype (Beeson and Bender, 1975, J. Exp. Zool. 193: 177-90).
In the presence of su(lz34), lz34 flies have virtually normal
eyes. Beeson and Bender were unable to confirm previous
observations of Bender and Green (1960, Genetics 45: 1563-66)
that su(lz34) increases the fecundity of lz34 females. Unaffected by su(f)6 (Schalet) or su(Hw)2; however suppressed by
su(pr) and enhanced by su(s) and su(wa) (Rutledge, Mortin,
Schwarz, Thierry-Mieg, and Meselson, 1988, Genetics
119: 391-97). RK1.
Eyes reduced and diamond shaped; color opaque brown.
Homozygous females sterile. lz35/lz females fertile. RK1.
Eye size reduced. Areas of irregular facets in posterior region of eye; eye color normal. Enhanced by su(f)6
(Schalet, 1970, Genen. Phaenen 14: 16-17); also enhanced by
su(Hw)2 and su(s) (Rutledge, Mortin, Schwarz, Thierry-Mieg,
and Meselson, Genetics 119: 391-97). Phenol oxidase level
decreased from 94% to 58% of normal (Snyder and Smith, 1976,
Biochem. Genet. 14: 611-17). RK1.
Unaffected by su(f)6 (Schalet).
Eye size sharply reduced; surface smooth; red pigment distributed over entire eye. Tarsal claws normal. Spermathecae and parovaria present and normal in females, which
are fertile. Complements all lz alleles tested except lz50e.
Like lz49h. Eyes reduced in size and almond shaped;
no indication of facets; covered with indentations, giving a
pock-marked appearance. Hairs on eye surface sparse or
absent; eye surface glossy with many large black or brown
flecks. Tarsal claws normal. Females fertile; spermathecae
and parovaria present and normal. lz50e/lz has normal eyes
except for a few flecks. Complements most other lz alleles
except lz49h, lz52c, and those associated with rearrangements
or deficiencies. Unaffected by su(f)6 (Schalet). RK1.
Eyes mottled, yellowish brown, darker at rim; facets
fused. Males semisterile with missing tarsal claws, although
pulvilli and endopodia normal. Third antennal segment
slightly reduced. lz52c/lz50e females resemble lz50e. RK1.
Eyes reduced in size and ovoid; facets fused; surface slightly rough and almost or completely hairless; color
light brown with darker, slightly reddish rim; almost colorless in combination with v. Tarsal claws practicaly absent as
in lzc1. Males sterile, (possibly associated with X-autosome
translocation), transmit no motile sperm to females; therefore, homozygous females not observed. lz59/lz37 females
intermediate between the two mutants in eye phenotype, have
reduced tarsal claws, and are weakly fertile. RK2.
Facets completely fused; eye color dark, but pigment
unevenly distributed and concentrated at margin. Females
found to be fertile by Burdicks, but were sterile when studied
by Schwalm, Bender, and Klingle (1970, DIS 45: 91) who studied the ultrastructure of eggs produced by homozygous
females. lz61f/lz females more nearly normal than either
mutant; facets disrupted and fused only in posterior third of
eye; also fertile. RK1.
Eye shape oval; color brown, darkest at margin; surface smooth and glossy. Viability and fertility of both sexes
Eye size moderately reduced; surface smooth; color
brownish with darker margin. Tarsal claws and pulvilli
strongly reduced. Spermathecae and parovaria absent; female
reproductive capability strongly reduced. lz63f complements
lz50e but not lz34, lzD, or lz61f (Klingele). Spermathecal
number of lz63f/lzK 0-3. RK1.
Phenol oxidase activity severely reduced; further
reduced in presence of su(f) (Snyder and Smith), 1976,
Biochem. Genet. 14: 611-17.
Eyes narrow and small without facets; surface has
rough spots; color amber, both pteridines and ommochromes
affected, darker at rim. Tarsal claws absent. Third antennal
segment reduced; sensilla on antennae abnormal. Phenotype
similar in both sexes. Females infertile and lack spermathecae and parovaria. Autonomous in transplants. RK1.
Males and homozygous females resemble lzs. Heterozygous females sometimes have roughened eyes. Apparent dominance shown by H. Bender to be caused by the presence of
spae(lz); heterozygous expression additionally enhanced by
presence of In(2LR)bwV1.
Eyes smaller than wild type; surface glossy from
fused facets; a few normal facets also present; color dark
blood red, bright red in combination with st or v. Larval
Malpighian tubes slightly lighter than normal (Brehme and Demerec, 1942, Growth 6: 351-56). Tarsal claws reduced. Spermathecae and parovaria absent from homozygous females, which
have reduced fertility; lzg/+ females tend to have abnormal
parovaria [Anderson, 1945, Genetics 30: 280-96 (fig.)]. RK1.
Eyes of male reduced and roughened like Gl; color
dark; female eyes somewhat less extreme. lzgl/lz intermediate
between lzg1 and lz and sterile. Homozygous females fertile.
lzK: lozenge of Krivshenko
Eyes narrow and moderately rough; facets irregular;
eyes of homozygous females more nearly normal than those of
males. Tarsal claws normal. Females fertile; spermathecae
and parovaria present. Interactions of lzK with other lz
alleles described by Green [1961, Genetics 46: 1169-76
(fig.)]. Unaffected by su(f)6 or su(Hw)2; however suppressed
by su(pr) and enhanced by su(s) and su(wa) (Rutledge, Mortin,
Schwarz, Thierry-Mieg, and Meselson, 1988, Genetics
119: 391-97). RK1.
Eyes small and oval; surface glossy; color brownish.
Tarsal claws missing. Homozygous females moderately fertile,
although spermathecae absent; lzM58/lzs also fertile. RK1.
Eye size reduced, narrower than normal; no true
facets; whole eye has glossy surface; color yellow-brown with
darker rim, creamy in combination with v. Tarsal claws vestigial. Homozygous females lack spermathecae and parovaria and
are sterile. lzs/+ females tend to have abnormal parovaria
(Anderson, 1945, Genetics 30: 280-96). RK1.
lzy4: lozenge in yellow-4
Similar to lzs but eye color redder. Homozygous
females lack spermathecae and parovaria and are sterile;
lzy4/+ females have abnormal parovaria and tend to lack spermathecae and parovaria (Anderson, 1945, Genetics 30: 280-96).