m6, E(spl)m6, HLHm6, E(spl) region transcript m6
Gene model reviewed during 5.42
Gene model reviewed during 5.48
There is only one protein coding transcript and one polypeptide associated with this gene
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\E(spl)m6-BFM using the Feature Mapper tool.
m6 transcripts are first detected in stage 9 embryos in the developing CNS. After germ band retraction, they are observed in the brain, the ventral nerve cord, and in the presumptive PNS. Weak expression is observed in imaginal discs. Specific staining is seen in the notal anlagen of the wing disc.
GBrowse - Visual display of RNA-Seq signalsView Dmel\E(spl)m6-BFM in GBrowse 2
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Source for identity of: E(spl)m6-BFM m6
The distinct expression patterns of genes of the E(spl) complex in imaginal tissues depend to a significant degree on the capacity of their transcriptional cis-regulatory apparatus to respond selectively to direct proneural and Su(H)-mediated activation, often in a subset of the territories and cells in which proneural and Su(H) regulation is occurring.
E(spl) bHLH proteins are turned on in cells which are inhibited from becoming neural by signals from the delaminating neuroblast.
Arrangement and sequence of E(spl)-complex genes in D.melanogaster and D.hydei revealed that the E(spl)-gene, and the structure of complex are highly conserved, suggesting that each individual gene, as well as the organization of the complex, is of functional importance.
The neurogenic phenotype of various embryonic combinations have been studied and include intermediate neurogenic embryos and weak neurogenic embryos.