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FB2021_04, released August 17, 2021

Gene: Dmel\E(spl)m7-HLH

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General Information
Symbol
Dmel\E(spl)m7-HLH
Species
D. melanogaster
Name
Enhancer of split m7, helix-loop-helix
Annotation Symbol
CG8361
Feature Type
protein_coding_gene
FlyBase ID
FBgn0002633
Gene Model Status
Current
Stock Availability
15 publicly available
Gene Summary
Participates in the control of cell fate choice by uncommitted neuroectodermal cells in the embryo. Transcriptional repressor. Binds DNA on N-box motifs: 5'-CACNAG-3'. (UniProt, P13097)
Contribute a Gene Snapshot for this gene.
All Summaries
Also Known As

m7, E(spl)m7, HLHm7, E(spl) region transcript m7, Enhancer of split m7

Key Links
Genomic Location
Cytogenetic map
96F10-96F10
Sequence location
3R:26,037,038..26,038,019 [+]
Recombination map
3-89
RefSeq locus
NT_033777 REGION:26037038..26038019
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
GO Summary Ribbons
Gene Ontology (GO) Annotations (10 terms)
Molecular Function (6 terms)
Terms Based on Experimental Evidence (3 terms)
CV Term
Evidence
References
enables DNA-binding transcription repressor activity, RNA polymerase II-specific
inferred from direct assay
(van Doren et al., 1994)
enables sequence-specific double-stranded DNA binding
inferred from direct assay
(assigned by UniProt )
(Li et al., 2017)
enables transcription factor binding
inferred from genetic interaction with FLYBASE:gro; FB:FBgn0001139
(Giagtzoglou et al., 2003)
inferred from genetic interaction with FLYBASE:sc; FB:FBgn0004170
(Giagtzoglou et al., 2003)
inferred from genetic interaction with FLYBASE:da; FB:FBgn0267821
(Giagtzoglou et al., 2003)
Terms Based on Predictions or Assertions (3 terms)
CV Term
Evidence
References
enables DNA-binding transcription factor activity, RNA polymerase II-specific
inferred from biological aspect of ancestor with PANTHER:PTN004213585
(assigned by GO_Central )
(Gaudet et al., 2011)
enables protein dimerization activity
inferred from electronic annotation with InterPro:IPR011598
(assigned by InterPro )
(FlyBase Curators et al., 2004-)
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding
inferred from biological aspect of ancestor with PANTHER:PTN004213585
(assigned by GO_Central )
(Gaudet et al., 2011)
Biological Process (3 terms)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
involved_in negative regulation of transcription by RNA polymerase II
inferred from direct assay
(Giagtzoglou et al., 2003, van Doren et al., 1994)
inferred from mutant phenotype
(Giagtzoglou et al., 2003)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
involved_in anterior/posterior pattern specification
inferred from biological aspect of ancestor with PANTHER:PTN000105428
(assigned by GO_Central )
(Gaudet et al., 2011)
involved_in regulation of transcription by RNA polymerase II
inferred from biological aspect of ancestor with PANTHER:PTN004213585
(assigned by GO_Central )
(Gaudet et al., 2011)
Cellular Component (1 term)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
is_active_in nucleus
inferred from biological aspect of ancestor with PANTHER:PTN004213585
(assigned by GO_Central )
(Gaudet et al., 2011)
Gene Group (FlyBase)
Protein Family (UniProt)
-
Protein Signatures (InterPro)
Summaries
Gene Group (FlyBase)
ENHANCER OF SPLIT GENE COMPLEX -
The Enhancer of split complex (E(spl)-C) of D.mel is a well characterized genetic locus on chromosome 3R containing 12 genes - with the exception of Kaz-m1, all are Notch responsive. Seven genes are basic helix-loop-helix (bHLH) transcription factors, four are bearded family genes. Kaz-m1 is unrelated, sharing some sequence similarity to Kazal class protease inhibitors. (Adapted from FBrf0211195).
BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS -
Basic helix-loop-helix (bHLH) transcription factors are sequence-specific DNA-binding proteins that regulate transcription. They are characterized by a 60 amino acid region comprising a basic DNA binding domain followed by a HLH motif formed from two amphipathic α-helices connected by a loop. bHLH transcription factors form homo- and hetero-dimeric complexes, which bind to a E box consensus sequence. (Adapted from PMID:15186484).
Protein Function (UniProtKB)
Participates in the control of cell fate choice by uncommitted neuroectodermal cells in the embryo. Transcriptional repressor. Binds DNA on N-box motifs: 5'-CACNAG-3'.
(UniProt, P13097)
Summary (Interactive Fly)

neurogenic bHLH transcription factor - Hairy/E(spl) class - an inhibitor of neural fate - Hairy/E(spl) class - E(spl)m7 and E(spl)m8 proteins are involved in the antagonistic regulation of the proneural gene and also regulate the expression of one or more of proneural target genes

Gene Model and Products
Number of Transcripts
1
Number of Unique Polypeptides
1

Please see the JBrowse view of Dmel\E(spl)m7-HLH for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model

Gene model reviewed during 5.42

Gene model reviewed during 5.48

Sequence Ontology: Class of Gene
nuclear_gene
protein_coding_gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
E(spl)m7-HLH-RA
FBtr0084960
NM_080505
982
186
Additional Transcript Data and Comments
Reported size (kB)

1.5 (northern blot)

(Knust et al., 1987)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
E(spl)m7-HLH-PA
FBpp0084334
20.7
186
9.63
NP_536753
AAF56554
Polypeptides with Identical Sequences

There is only one protein coding transcript and one polypeptide associated with this gene

Additional Polypeptide Data and Comments
Reported size (kDa)

186 (aa); 20.5 (kD predicted)

(Klambt et al., 1989)
Comments
External Data
Subunit Structure (UniProtKB)

Transcription repression requires formation of a complex with a corepressor protein (Groucho). Forms homodimers.

(UniProt, P13097)
Domain

The orange domain and the basic helix-loop-helix motif mediate repression of specific transcriptional activators, such as basic helix-loop-helix protein dimers.

The C-terminal WRPW motif is a transcriptional repression domain necessary for the interaction with Groucho, a transcriptional corepressor recruited to specific target DNA by Hairy-related proteins.

(UniProt, P13097)
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\E(spl)m7-HLH using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 4 -- 6
ventral ectoderm anlage

Comment: anlage in statu nascendi

(Fisher et al., 2012)
embryonic stage 5
organism | striped
(Knust et al., 1987)
mesectoderm
(Rao et al., 1991)
embryonic stage 6 -- 8
mesectoderm
(Wech et al., 1999)
amnioserosa anlage
(Wech et al., 1999)
embryonic stage 7 -- 8
antennal anlage

Comment: reported as procephalic ectoderm anlage

(Fisher et al., 2012)
central brain anlage

Comment: reported as procephalic ectoderm anlage

(Fisher et al., 2012)
dorsal head epidermis anlage

Comment: reported as procephalic ectoderm anlage

(Fisher et al., 2012)
visual anlage

Comment: reported as procephalic ectoderm anlage

(Fisher et al., 2012)
ventral ectoderm
(Fisher et al., 2012)
embryonic stage 8 -- 11
ventral neurectoderm
(Wech et al., 1999)
proneural cluster
(Wech et al., 1999)
embryonic stage 9
endoderm

Comment: transiently expressed

(Wech et al., 1999)
embryonic stage 9 -- 10
antennal primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
central brain primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
visual primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
dorsal head epidermis primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
lateral head epidermis primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
ventral head epidermis primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
dorsal ectoderm
(Fisher et al., 2012)
organism | ubiquitous
(Fisher et al., 2012)
ventral ectoderm
(Fisher et al., 2012)
embryonic stage 10
posterior midgut primordium
(Knust et al., 1987)
supraesophageal ganglion
(Knust et al., 1987)
embryonic stage 11
mesoderm
(Wech et al., 1999)
embryonic stage 11 -- 12
dorsal epidermis primordium
(Fisher et al., 2012)
dorsal head epidermis primordium

Comment: reported as head epidermis primordium

(Fisher et al., 2012)
lateral head epidermis primordium

Comment: reported as head epidermis primordium

(Fisher et al., 2012)
ventral head epidermis primordium

Comment: reported as head epidermis primordium

(Fisher et al., 2012)
organism | ubiquitous
(Fisher et al., 2012)
ventral epidermis primordium
(Fisher et al., 2012)
visual primordium
(Fisher et al., 2012)
embryonic stage 11 -- 14
embryonic optic lobe primordium
(Knust et al., 1987)
stomatogastric nervous system primordium
(Knust et al., 1987)
embryonic stage 12 -- 15
embryonic head segment
(Wech et al., 1999)
embryonic thoracic segment
(Wech et al., 1999)
embryonic stage 13 -- 16
embryonic pars intercerebralis
(Fisher et al., 2012)
embryonic dorsal epidermis
(Fisher et al., 2012)
embryonic epipharynx
(Fisher et al., 2012)
embryonic head epidermis
(Fisher et al., 2012)
embryonic hindgut
(Fisher et al., 2012)
embryonic hypopharynx
(Fisher et al., 2012)
embryonic primordium of adult eye

Comment: reported as visual system

(Fisher et al., 2012)
embryonic ventral epidermis
(Fisher et al., 2012)
embryonic optic lobe primordium
(Fisher et al., 2012)
third instar larval stage
lamina
(Wang et al., 2013)
northern blot
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 5
yolk nucleus
(Knust et al., 1987)
embryonic stage 7 -- 11
ectoderm
(Knust et al., 1987)
embryonic stage 11
epidermis | restricted

Comment: late stage 11

(Knust et al., 1987)
embryonic stage 11 -- 12
mesoderm
(Knust et al., 1987)
embryonic stage 11 -- 13

Comment: reference states 6-10 hr AEL

(Knust et al., 1987)
RT-PCR
Stage
Tissue/Position (including subcellular localization)
Reference
wandering third instar larval stage
organism
(Maeder et al., 2009)
prepupal stage
organism
(Maeder et al., 2009)
Additional Descriptive Data

E(spl) genes were found to be differentially expressed during metamorphosis.

(Maeder et al., 2009)

The peak of HLHm7 expression during embryogenesis occurs at 6-10 hours. In the late blastoderm, expression is detected in a 2-3 cell-wide stripe on each side of the embryo, in groups of cells over the dorsal half of the poles, in the vitellophage, and in a dorsomedian band spanning the anterioposterior axis. During germ band extension, ectodermal expression is detected, and at the extended germ band stage, epidermal expression is abundant. In late stage 11, epidermal expression becomes patchy. At stage 10, the primordia of the supraoesophageal ganglion and the posterior midgut express HLHm7. From stage 11 through late stage 12, expression is detected in the entire mesodermal layer. From late stage 11 through stage 14, expression is also detected in the primordia of the stomatogastric nervous system and in the optic lobes.

(Knust et al., 1987)
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\E(spl)m7-HLH in GBrowse 2
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
DRscDB
EMBL-EBI Single Cell Expression Atlas
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
Flygut - An atlas of the Drosophila adult midgut
Images
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 12 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 22 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of E(spl)m7-HLH
Transgenic constructs containing regulatory region of E(spl)m7-HLH
Aberrations (Deficiencies and Duplications) ( 21 )
Alleles Representing Disease-Implicated Variants
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
lethal - all die before end of pupal stage, with Scer\GAL4h-1J3
viable
viable, with Dcr-2UAS.cDa, Scer\GAL4elav.PLu
viable, with Scer\GAL4Mef2.PR
viable, with Scer\GAL4pnr-MD237
viable, with Scer\GAL4tin.CΔ4
Other Phenotypes
Allele
abnormal neuroanatomy | embryonic stage (with Df(3R)BSC751)
increased cell number | embryonic stage (with Df(3R)BSC751)
increased occurrence of cell division | larval stage | conditional
some die during pupal stage, with Scer\GAL4h-1J3
visible, with Scer\GAL432B
visible, with Scer\GAL4455.2
visible, with Scer\GAL4ap-md544
visible, with Scer\GAL4dpp.blk1
visible, with Scer\GAL4h-1J3
visible, with Scer\GAL4pnr-MD237
visible, with Scer\GAL4ptc-559.1
visible, with Scer\GAL4sca-537.4
visible | male limited, with Scer\GAL4Bx-MS1096
Phenotype manifest in
Allele
adult mesothoracic segment, with Scer\GAL4pnr-MD237
adult thorax, with Scer\GAL4pnr-MD237
anterior wing margin, with Scer\GAL4bi-md653
apterous-expressing neuron of the lateral cluster of the thorax | embryonic stage | increased number (with Df(3R)BSC751)
campaniform sensillum of anterior crossvein | ectopic, with Scer\GAL4ptc-559.1
chaeta, with Scer\GAL4ap-md544
chaeta, with Scer\GAL4pnr-MD237
dorsal mesothoracic disc & sensory mother cell, with Scer\GAL4455.2
eye, with Scer\GAL4GMR.PF
interommatidial bristle, with Scer\GAL4GMR.PF
larval intersegmental nerve, with Scer\GAL4elav-C155
leg & macrochaeta, with Scer\GAL430A
macrochaeta
macrochaeta, with Scer\GAL4h-1J3
macrochaeta, with Scer\GAL4pnr-MD237
macrochaeta, with Scer\GAL4sca-537.4
macrochaeta | ectopic, with Scer\GAL4h-1J3
macrochaeta | ectopic, with Scer\GAL4ptc-559.1
mesothoracic tergum, with Scer\GAL4ap-md544
mesothoracic tergum, with Scer\GAL4pnr-MD237
mesothoracic tergum & macrochaeta, with Scer\GAL4sca-C253
microchaeta, with Scer\GAL4pnr-MD237
scutellar bristle, with Scer\GAL4455.2
scutellar bristle, with Scer\GAL4dpp.blk1
scutellar bristle, with Scer\GAL4pnr-MD237
scutellar bristle, with Scer\GAL4ptc-559.1
scutellum & macrochaeta, with Scer\GAL4h-1J3
scutum, with Scer\GAL4ptc-559.1
scutum & macrochaeta, with Scer\GAL4ap-md544
scutum & macrochaeta, with Scer\GAL4h-1J3
scutum & macrochaeta, with Scer\GAL4ptc-559.1
scutum & microchaeta, with Scer\GAL432B
scutum & microchaeta, with Scer\GAL4ap-md544
sensory mother cell, with Scer\GAL4sca-C253
sensory mother cell | ectopic, with Scer\GAL4455.2
wing, with Scer\GAL4ptc-559.1
wing & macrochaeta, with Scer\GAL469B
wing & macrochaeta, with Scer\GAL4ptc-559.1
wing & sensory mother cell, with Scer\GAL4455.2
wing | male limited, with Scer\GAL4Bx-MS1096
wing margin bristle, with Scer\GAL432B
wing margin bristle, with Scer\GAL4bi-md653
wing vein, with Scer\GAL432B
wing vein, with Scer\GAL4en.PU
wing vein | ectopic, with Scer\GAL469B
wing vein L2, with Scer\GAL469B
wing vein L4, with Scer\GAL469B
Orthologs
Downloads
Download All DIOPT Orthologs
Download All OrthoDB Orthologs
Human Orthologs (via DIOPT v8.0)
Homo sapiens (Human) (13)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Hsap\HES6
6 of 15
Yes
No
Hsap\HES1
4 of 15
No
No
Hsap\HES2
4 of 15
No
No
Hsap\HES4
4 of 15
No
No
1  
Hsap\BHLHE40
3 of 15
No
Yes
Hsap\BHLHE41
3 of 15
No
Yes
2  
Hsap\HES3
3 of 15
No
Yes
Hsap\HES7
3 of 15
No
Yes
Hsap\HELT
2 of 15
No
No
Hsap\HES5
2 of 15
No
No
Hsap\HEY1
2 of 15
No
No
Hsap\HEY2
2 of 15
No
No
1  
Hsap\HEYL
2 of 15
No
No
Model Organism Orthologs (via DIOPT v8.0)
Mus musculus (laboratory mouse) (12)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Mmus\Hes2
5 of 15
Yes
No
Mmus\Hes6
5 of 15
Yes
No
Mmus\Hes1
4 of 15
No
No
Mmus\Bhlhe40
3 of 15
No
Yes
Mmus\Bhlhe41
3 of 15
No
Yes
Mmus\Hes3
3 of 15
No
Yes
Mmus\Hes7
3 of 15
No
Yes
Mmus\Helt
2 of 15
No
Yes
Mmus\Hes5
2 of 15
No
No
Mmus\Hey1
2 of 15
No
No
Mmus\Hey2
2 of 15
No
No
Mmus\Heyl
2 of 15
No
No
Rattus norvegicus (Norway rat) (11)
Rnor\Hes6
7 of 13
Yes
Yes
Rnor\Hes1
4 of 13
No
No
Rnor\Hes2
4 of 13
No
No
Rnor\Bhlhe40
3 of 13
No
Yes
Rnor\Bhlhe41
3 of 13
No
Yes
Rnor\Hes3
3 of 13
No
Yes
Rnor\Hes7
3 of 13
No
Yes
Rnor\Helt
2 of 13
No
No
Rnor\Hes5
2 of 13
No
No
Rnor\Hey2
2 of 13
No
No
Rnor\Heyl
2 of 13
No
No
Xenopus tropicalis (Western clawed frog) (17)
Xtro\hes6.1
5 of 12
Yes
Yes
Xtro\hes1
4 of 12
No
No
Xtro\hes2
4 of 12
No
No
Xtro\hes4
4 of 12
No
No
Xtro\hes6.2
4 of 12
No
Yes
Xtro\bhlhe40
3 of 12
No
Yes
Xtro\bhlhe41
3 of 12
No
Yes
Xtro\hes7.1
3 of 12
No
Yes
Xtro\hes7.2
3 of 12
No
Yes
Xtro\esr10
2 of 12
No
No
Xtro\hes3.3
2 of 12
No
No
Xtro\hes5.1
2 of 12
No
No
Xtro\hes9.1
2 of 12
No
No
Xtro\hey1
2 of 12
No
No
Xtro\hey2
2 of 12
No
No
Xtro\hes3.1
1 of 12
No
No
Xtro\hes5.2
1 of 12
No
No
Danio rerio (Zebrafish) (29)
Drer\her8a
8 of 15
Yes
No
Drer\her8.2
7 of 15
No
Yes
Drer\hes6
6 of 15
No
Yes
Drer\her13
5 of 15
No
Yes
Drer\her6
4 of 15
No
No
Drer\her9
4 of 15
No
No
Drer\hes2.1
4 of 15
No
Yes
Drer\hes2.2
4 of 15
No
Yes
Drer\bhlhe40
3 of 15
No
Yes
Drer\bhlhe41
3 of 15
No
Yes
Drer\her1
3 of 15
No
Yes
Drer\her3
3 of 15
No
Yes
Drer\her5
3 of 15
No
Yes
Drer\her7
3 of 15
No
No
Drer\her11
3 of 15
No
No
Drer\helt
2 of 15
No
No
Drer\her2
2 of 15
No
No
Drer\her4.2
2 of 15
No
No
Drer\her4.4
2 of 15
No
No
Drer\her12
2 of 15
No
No
Drer\her15.2
2 of 15
No
No
Drer\hey1
2 of 15
No
No
Drer\hey2
2 of 15
No
No
Drer\heyl
2 of 15
No
No
Drer\her4.1
1 of 15
No
No
Drer\her4.3
1 of 15
No
No
Drer\her4.5
1 of 15
No
No
Drer\her15.1
1 of 15
No
No
Drer\LOC108180270
1 of 15
No
Yes
Caenorhabditis elegans (Nematode, roundworm) (3)
Cele\lin-22
6 of 15
Yes
No
Cele\hlh-25
1 of 15
No
Yes
Cele\hlh-27
1 of 15
No
Yes
Arabidopsis thaliana (thale-cress) (0)
No records found.
Saccharomyces cerevisiae (Brewer's yeast) (1)
Scer\PHO4
1 of 15
Yes
No
Schizosaccharomyces pombe (Fission yeast) (0)
No records found.
Ortholog(s) in Drosophila Species (via OrthoDB v9.1) ( EOG09190HN7 )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila simulans
Dsim\HLHm7
Drosophila sechellia
Dsec\GM10299
Drosophila erecta
Dere\GG11458
Drosophila yakuba
Dyak\HLHm7
Drosophila ananassae
Dana\GF16801
Drosophila pseudoobscura pseudoobscura
Dpse\GA21018
Drosophila persimilis
Dper\GL21822
Drosophila willistoni
Dwil\GK14459
Drosophila virilis
Dvir\GJ23909
Drosophila mojavensis
Dmoj\GI24692
Drosophila grimshawi
Dgri\GH19458
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG09150BTH )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Mdoa\17010970
Musca domestica
House fly
Mdoa\17012075
Musca domestica
House fly
Mdoa\17012076
Glossina morsitans
Tsetse fly
Gmor\GMOY006398
Glossina morsitans
Tsetse fly
Gmor\GMOY006397
Glossina morsitans
Tsetse fly
Gmor\GMOY006401
Lucilia cuprina
Australian sheep blowfly
Lcup\FF38_11444
Lucilia cuprina
Australian sheep blowfly
Lcup\FF38_11431
Lucilia cuprina
Australian sheep blowfly
Lcup\FF38_10177
Mayetiola destructor
Hessian fly
Mdes\Mdes007062
Aedes aegypti
Yellow fever mosquito
Aaeg\AAEL004097
Anopheles gambiae
Malaria mosquito
Agam\AGAP012342
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ003409
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W0FLV )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Bombyx mori
Silkmoth
Bmor\BGIBMGA008915
Bombyx mori
Silkmoth
Bmor\BGIBMGA008965
Danaus plexippus
Monarch butterfly
Dple\DPOGS200691-PA
Danaus plexippus
Monarch butterfly
Dple\DPOGS200684-PA
Heliconius melpomene
Postman butterfly
Hmel\HMEL008302
Heliconius melpomene
Postman butterfly
Hmel\HMEL013921
Apis florea
Little honeybee
Aflo\2914096532
Apis florea
Little honeybee
Aflo\4364196260
Apis florea
Little honeybee
Aflo\2914096500
Apis mellifera
Western honey bee
Amel\LOC409822
Apis mellifera
Western honey bee
Amel\GB43788
Apis mellifera
Western honey bee
Amel\GB43791
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP19727
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP19724
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP19733
Bombus terrestris
Buff-tailed bumblebee
Bter\15203900
Bombus terrestris
Buff-tailed bumblebee
Bter\15203905
Bombus terrestris
Buff-tailed bumblebee
Bter\15203903
Linepithema humile
Argentine ant
Lhum\LH16583
Linepithema humile
Argentine ant
Lhum\LH16586
Linepithema humile
Argentine ant
Lhum\LH11777
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:000d41
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:000d3c
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:000d39
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_12730
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_12734
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_12733
Tribolium castaneum
Red flour beetle
Tcas\TC006580
Tribolium castaneum
Red flour beetle
Tcas\TC005541
Pediculus humanus
Human body louse
Phum\PHUM375920
Pediculus humanus
Human body louse
Phum\PHUM375930
Rhodnius prolixus
Kissing bug
Rpro\RPRC006229
Cimex lectularius
Bed bug
Clec\CLEC002262
Cimex lectularius
Bed bug
Clec\CLEC002260
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI003697
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI009737
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_06330
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_06326
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X0FLT )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strigamia maritima
European centipede
Smar\SMAR012126
Strigamia maritima
European centipede
Smar\SMAR005357
Strigamia maritima
European centipede
Smar\SMAR004356
Strigamia maritima
European centipede
Smar\SMAR005137
Strigamia maritima
European centipede
Smar\SMAR005355
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_302410
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_64307
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_299514
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G0P1S )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Hairy
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Hey4
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v8.0)
Drosophila melanogaster (Fruit fly) (12)
Gene Symbol
Score
Source
Compara
eggNOG
Homologene
Inparanoid
Isobase
OrthoDB
OrthoFinder
orthoMCL
Panther
RoundUp
Alignment
E(spl)m3-HLH
6 of 10
E(spl)mβ-HLH
6 of 10
E(spl)mγ-HLH
6 of 10
E(spl)m5-HLH
5 of 10
E(spl)m8-HLH
5 of 10
E(spl)mδ-HLH
5 of 10
dpn
4 of 10
h
4 of 10
Sidpn
4 of 10
cwo
3 of 10
Hesr
2 of 10
Hey
2 of 10
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Model Summary Ribbon
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 1 )
    Human Ortholog
    Disease
    Evidence
    References
    HES7; hes family bHLH transcription factor 7
    model of  spondylocostal dysostosis
    IEA
    (FlyBase, 2019-)
    Modifiers Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Interaction
    References
    Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    HES6; hes family bHLH transcription factor 6
    6 of 15
    610331
        HES1; hes family bHLH transcription factor 1
        4 of 15
        139605
            HES2; hes family bHLH transcription factor 2
            4 of 15
            609970
                HES4; hes family bHLH transcription factor 4
                4 of 15
                608060
                     
                    BHLHE40; basic helix-loop-helix family member e40
                    3 of 15
                    604256
                        BHLHE41; basic helix-loop-helix family member e41
                        3 of 15
                        606200
                           
                          HES3; hes family bHLH transcription factor 3
                          3 of 15
                          609971
                              HES7; hes family bHLH transcription factor 7
                              3 of 15
                              608059
                              Functional Complementation Data
                              Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
                              Interactions
                              Summary of Physical Interactions
                              esyN Network Diagram
                              Show neighbor-neighbor interactions:
                              Select Layout:
                              Legend:
                              Protein
                              RNA
                              Selected Interactor(s)
                              Interactions Browser
                              View in Interactions Browser
                              Please see the Physical Interaction reports below for full details
                              protein-protein
                              Physical Interaction
                              Assay
                              References
                              E(spl)m7-HLH - E(spl)m5-HLH
                              two hybrid
                              (Alifragis et al., 1997)
                              E(spl)m7-HLH - E(spl)m8-HLH
                              two hybrid
                              (Alifragis et al., 1997)
                              E(spl)m7-HLH - E(spl)mβ-HLH
                              two hybrid
                              (Alifragis et al., 1997)
                              E(spl)m7-HLH - E(spl)mγ-HLH
                              two hybrid
                              (Alifragis et al., 1997)
                              E(spl)m7-HLH - E(spl)mδ-HLH
                              two hybrid
                              (Alifragis et al., 1997)
                              E(spl)m7-HLH - ac
                              two hybrid
                              (Alifragis et al., 1997)
                              E(spl)m7-HLH - ase
                              two hybrid
                              (Alifragis et al., 1997)
                              E(spl)m7-HLH - ato
                              two hybrid
                              (Alifragis et al., 1997)
                              E(spl)m7-HLH - da
                              anti tag coimmunoprecipitation, anti tag western blot, two hybrid, one hybrid
                              (Kiparaki et al., 2015, Zarifi et al., 2012, Alifragis et al., 1997)
                              E(spl)m7-HLH - dgrn
                              pull down, autoradiography
                              (Barry et al., 2011)
                              E(spl)m7-HLH - gro
                              two hybrid, pull down, western blot, anti tag coimmunoprecipitation, autoradiography, inferred by curator
                              (Kiparaki et al., 2015, Zarifi et al., 2012, Bejarano et al., 2007, Jennings et al., 2006, Giagtzoglou et al., 2005, Goldstein et al., 1999, Levanon et al., 1998, Alifragis et al., 1997, Fisher et al., 1996, Paroush et al., 1994)
                              E(spl)m7-HLH - sc
                              two hybrid, pull down, autoradiography, one hybrid, anti tag coimmunoprecipitation, anti tag western blot
                              (Kiparaki et al., 2015, Zarifi et al., 2012, Giagtzoglou et al., 2005, Alifragis et al., 1997)
                              Summary of Genetic Interactions
                              esyN Network Diagram
                              esyN Network Key:
                              Suppression
                              Enhancement
                              View in Interactions Browser
                              Please look at the allele data for full details of the genetic interactions
                              Starting gene(s)
                              Interaction type
                              Interacting gene(s)
                              Reference
                              E(spl)m7-HLH
                              suppressible
                              btl::Egfr
                              (Hasson et al., 2005)
                              Starting gene(s)
                              Interaction type
                              Interacting gene(s)
                              Reference
                              lok
                              suppressible
                              E(spl)m7-HLH
                              (Park and Song, 2008)
                              N
                              enhanceable
                              E(spl)m7-HLH
                              (Ligoxygakis et al., 1999, Nagel et al., 1999)
                              sc
                              suppressible
                              E(spl)m7-HLH
                              (Giagtzoglou et al., 2003)
                              Su(H)
                              suppressible
                              E(spl)m7-HLH
                              (Klein et al., 2000)
                              uif
                              suppressible
                              E(spl)m7-HLH
                              (Xie et al., 2012)
                              External Data
                              Subunit Structure (UniProtKB)
                              Transcription repression requires formation of a complex with a corepressor protein (Groucho). Forms homodimers.
                              (UniProt, P13097 )
                              Linkouts
                              BioGRID - A database of protein and genetic interactions.
                              DroID - A comprehensive database of gene and protein interactions.
                              MIST (genetic) - An integrated Molecular Interaction Database
                              MIST (protein-protein) - An integrated Molecular Interaction Database
                              Pathways
                              Signaling Pathways (FlyBase)
                              Metabolic Pathways
                              External Data
                              Linkouts
                              Genomic Location and Detailed Mapping Data
                              Chromosome (arm)
                              3R
                              Recombination map
                              3-89
                              Cytogenetic map
                              96F10-96F10
                              Sequence location
                              3R:26,037,038..26,038,019 [+]
                              FlyBase Computed Cytological Location
                              Cytogenetic map
                              Evidence for location
                              96F10-96F10
                              Limits computationally determined from genome sequence between P{PZ}l(3)rQ197rQ197 and P{lacW}scribj7B3
                              Experimentally Determined Cytological Location
                              Cytogenetic map
                              Notes
                              References
                              96F11-96F14
                              (Posakony, 1994.8.5)
                              Experimentally Determined Recombination Data
                              Location

                              3-89

                              (FlyBase, 2016)

                              3-87.4

                              (Comeron et al., 2012)

                              3-89.1

                              Left of (cM)
                              Right of (cM)
                              Notes
                              Stocks and Reagents
                              Stocks (15)
                              Genomic Clones (20)
                              cDNA Clones (13)
                               

                              Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

                              cDNA clones, fully sequenced
                              BDGP DGC clones
                              Other clones
                              Drosophila Genomics Resource Center cDNA clones

                              For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

                              cDNA Clones, End Sequenced (ESTs)
                              BDGP DGC clones
                                Other clones
                                RNAi and Array Information
                                Linkouts
                                DRSC - Results frm RNAi screens
                                GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
                                Antibody Information
                                Laboratory Generated Antibodies
                                 
                                Commercially Available Antibodies
                                 
                                Other Information
                                Relationship to Other Genes
                                Source for database identify of

                                Source for identity of: E(spl)m7-HLH HLHm7

                                (Artavanis-Tsakonas et al., 2012.8.8)
                                Source for database merge of
                                Additional comments
                                Other Comments

                                dsRNA has been made from templates generated with primers directed against this gene. RNAi of HLHm7 results in reduced arborization of ddaD and ddaE neurons, alterations in the number of MD neurons and defects in dendrite morphogenesis.

                                (Parrish et al., 2006)

                                The distinct expression patterns of genes of the E(spl) complex in imaginal tissues depend to a significant degree on the capacity of their transcriptional cis-regulatory apparatus to respond selectively to direct proneural and Su(H)-mediated activation, often in a subset of the territories and cells in which proneural and Su(H) regulation is occurring.

                                (Nellesen et al., 1999)

                                In a sample of 79 genes with multiple introns, 33 showed significant heterogeneity in G+C content among introns of the same gene and significant positive correspondence between the intron and the third codon position G+C content within genes. These results are consistent with selection adding against preferred codons at the start of genes.

                                (Kliman and Eyre-Walker, 1998)

                                E(spl) proteins normally mediate lateral inhibition by directly repressing proneural gene expression.

                                (Jimenez and Ish-Horowicz, 1997)

                                The bHLH domains of the gene products encoded by the E(spl)-C and AS-C differ in their ability to form homo- and/or heterodimers. The interactions established through the bHLH link the products of the two complexes in a single interaction network which may function to ensure that a given cell retains the capacity to choose between epidermoblast and neuroblast fates until the cell becomes definitively determined.

                                (Gigliani et al., 1996)

                                Clones mutant for E(spl)-C bHLH-encoding genes or for gro display bristle hyperplasia. The E(spl)-C genes participate in the N signalling pathway. E(spl)-C mutants are epistatic over a gain of function mutant of N and ac-sc mutants are epistatic over E(spl)-C mutants.

                                (Heitzler et al., 1996)

                                Almost all E(spl)-complex bHLH proteins can homo-hetero-dimerise, but not with the same efficiency. All E(spl)-complex bHLH proteins interact with gro protein via their C-terminal domain. E(spl)-complex bHLH proteins interact with proneural proteins, with members of the E(spl) family exhibiting distinct preferences for different proneural proteins.

                                (Alifragis et al., 1995)

                                The bristle loss phenotype of H mutants can be suppressed by deleting components of the E(spl)-complex. The degree of suppression depends on both the number and identity of E(spl)-complex transcription units removed.

                                (Bang et al., 1995)

                                E(spl) bHLH proteins are turned on in cells which are inhibited from becoming neural by signals from the delaminating neuroblast.

                                (Jennings et al., 1995)

                                Electrophoretic mobility shift assays demonstrate that HLHm7 is directly activated in proneural clusters of the late third-instar wing imaginal disc by protein complexes that include the ac and sc bHLH proteins.

                                (Singson et al., 1994)

                                Arrangement and sequence of E(spl)-complex genes in D.melanogaster and D.hydei revealed that the E(spl)-gene, and the structure of complex are highly conserved, suggesting that each individual gene, as well as the organization of the complex, is of functional importance.

                                (Maier et al., 1993)

                                E(spl) complex gene expression pattern in N and neur mutants suggests the protein is required in dictating cell fates during embryogenesis.

                                (Tata and Hartley, 1993)

                                On basis of cross-hybridization and sequence data the E(spl) HLH genes can be placed into 3 groups. The first includes E(spl) and HLHm5, the second includes HLHm7, HLHm3, HLHmA and HLHmB and the last includes HLHmC.

                                (Delidakis and Artavanis-Tsakonas, 1992)

                                Genes of the E(spl) complex act as a functional unit composed of redundant genes which can partially substitute for each other. Eight E(spl)-region genes are required for the development of neurectodermal cells: HLHmδ, HLHmβ, HLHmγ, HLHm3, HLHm5, HLHm7, E(spl) and gro. The E(spl)-region gene m4 may also play a role in this process.

                                (Schrons et al., 1992)

                                The neurogenic phenotype of various embryonic combinations have been studied and divided into extreme neurogenic embryo, intermediate neurogenic embryos, weak intermediate neurogenic embryos and weak neurogenic embryos.

                                (Delidakis et al., 1991)

                                Genetic analysis demonstrates that Dl, neu, E(spl), HLHm5, HLHm7 and m4 are functionally related. Spatial distribution of mRNA in neurogenic mutant embryos suggests that some of the functional interactions take place at the transcriptional level.

                                (Godt et al., 1991)

                                One of the Enhancer-of-split complex.

                                Origin and Etymology
                                Discoverer
                                Etymology
                                Identification
                                External Crossreferences and Linkouts ( 65 )
                                Sequence Crossreferences
                                NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
                                GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
                                GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
                                RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
                                UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
                                Other crossreferences
                                BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
                                Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
                                DRscDB
                                EMBL-EBI Single Cell Expression Atlas
                                Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
                                Flygut - An atlas of the Drosophila adult midgut
                                GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
                                iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
                                InterPro - A database of protein families, domains and functional sites
                                KEGG Genes - Molecular building blocks of life in the genomic space.
                                MARRVEL_MODEL
                                modMine - A data warehouse for the modENCODE project
                                Linkouts
                                BioGRID - A database of protein and genetic interactions.
                                DroID - A comprehensive database of gene and protein interactions.
                                DRSC - Results frm RNAi screens
                                FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
                                FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
                                FlyMine - An integrated database for Drosophila genomics
                                Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
                                MIST (genetic) - An integrated Molecular Interaction Database
                                MIST (protein-protein) - An integrated Molecular Interaction Database
                                Synonyms and Secondary IDs (20)
                                Reported As
                                Symbol Synonym
                                CG8361
                                (Ibrahim et al., 2013, Hadar et al., 2012, Ni et al., 2011.7.19, Keleman et al., 2009.8.5, Krejcí et al., 2009, Perkins et al., 2009, Bhutkar et al., 2008, Stevens et al., 2008, Stevens et al., 2008, Molnar et al., 2006, Schlatter and Maier, 2005, Moehring and Mackay, 2004, Norga et al., 2003, Kraut et al., 2001, Kraut et al., 2001)
                                E(SPL)m7
                                (Abmayr et al., 1992)
                                E(spl) m7
                                (Campos-Ortega, 1989.9.18)
                                E(spl)-M7
                                (Bandyopadhyay et al., 2016, Jennings et al., 1999)
                                E(spl)-m7
                                (Guo et al., 2019, Goldstein et al., 1999)
                                E(spl)M7
                                (Jennings et al., 1999)
                                E(spl)m7
                                (Li et al., 2020, Lo et al., 2019, Lan et al., 2018, Wissel et al., 2018, Prince and Rand, 2017, Bonfini et al., 2015, Kiparaki et al., 2015, Tseng et al., 2014, Babaoğlan et al., 2013, Wang et al., 2013, Yang et al., 2013, Engel et al., 2012, Xie et al., 2012, Zacharioudaki et al., 2012, Barry et al., 2011, Di Stefano et al., 2011, Duan et al., 2011, Eliazer and Buszczak, 2011, Jones et al., 2009, Krejcí et al., 2009, Li et al., 2009, Moshkin et al., 2009, Parks et al., 2008, Sun et al., 2008, Ayyar et al., 2007, Bejarano et al., 2007, Goodfellow et al., 2007, Acar et al., 2006, Seidner et al., 2006, Giagtzoglou et al., 2005, Lai et al., 2005, Zarifi et al., 2005, Ahmed et al., 2003, Giagtzoglou et al., 2003, Giagtzoglou et al., 2003, Karandikar et al., 2003, Brody et al., 2002, Lai, 2002, Rebeiz et al., 2002, Rohrbaugh et al., 2002, Giagtzoglou et al., 2001, Kalive et al., 2001, Ledent and Vervoort, 2001, Trott et al., 2001, Bhaskar et al., 2000, Ligoxygakis et al., 1999, Fisher and Caudy, 1998, Lai et al., 1998, Levanon et al., 1998, Liang and Biggin, 1998, Schweisguth and Lecourtois, 1998, Leviten et al., 1997, Barbash and Cline, 1995, Roark et al., 1995, Francois et al., 1994, Posakony, 1994.8.5, Singson et al., 1994, van Doren et al., 1994, Wainwright and Ish-Horowicz, 1992, Vaessin et al., 1990)
                                E(spl)m7-HLH
                                (Meltzer et al., 2019, Schertel et al., 2015, Victorsen and White, 2014.4.15, Wurmbach and Preiss, 2014)
                                ESPL
                                (Segev et al., 2001)
                                En(spl)m7
                                (Mitchell et al., 2008)
                                HLH-m7
                                (Campos-Ortega, 1993, Tietze et al., 1993)
                                HLHm7
                                (Flint Brodsly et al., 2019, King et al., 2019, Kok et al., 2015, Jiang and Singh, 2014, Rembold et al., 2014, Moshkin et al., 2013, Schaaf et al., 2013, Hadar et al., 2012, Japanese National Institute of Genetics, 2012.5.21, Fay et al., 2011, Johnson et al., 2011, Toku et al., 2011, Blanco et al., 2010, Duncan and Dearden, 2010, Jones et al., 2009, Parks and Muskavitch, 2009.2.4, Schaaf et al., 2009, Southall and Brand, 2009, Yamamoto et al., 2009, Bhutkar et al., 2008, Lu et al., 2008, Park and Song, 2008, Yamamoto et al., 2008, Buszczak et al., 2007, Maeder et al., 2007, Yamamoto et al., 2007, Hoskins et al., 2005, Liu et al., 2005, Reeves and Posakony, 2005)
                                HlHm7
                                (Ibrahim et al., 2013)
                                M7
                                (Bandyopadhyay et al., 2016, Parrish et al., 2006, Razin et al., 1999)
                                bHLHb35
                                (Stevens et al., 2008)
                                m7
                                (Couturier et al., 2019, Guo et al., 2019, Singh et al., 2019, Karaiskos et al., 2017, Bivik et al., 2016, Horvath et al., 2016, Ibrahim et al., 2013, Kux et al., 2013, Moshkin et al., 2013, San Juan et al., 2012, Zarifi et al., 2012, Cave et al., 2011, Li et al., 2011, Bardin et al., 2010, Duncan and Dearden, 2010, Chanet et al., 2009, Jones et al., 2009, Li et al., 2009, Maeder et al., 2009, Moshkin et al., 2009, Rand et al., 2008, Assa-Kunik et al., 2007, Eastman et al., 2007, Goodfellow et al., 2007, Krejci and Bray, 2007, Brody et al., 2006, Molnar et al., 2006, Papatsenko et al., 2006, Zinzen et al., 2006, Kan and Kessler, 2005, Klebes et al., 2005, Macdonald and Long, 2005, Macdonald et al., 2005, Schlatter and Maier, 2005, Nagel et al., 2004, Kumar and Moses, 2001, Kumar and Moses, 2001, Kumar and Moses, 2000, Lai et al., 2000, Govind, 1999, Nellesen et al., 1999, Wech et al., 1999, Wurmbach et al., 1999, Culi and Modolell, 1998, Dumstrei et al., 1998, Ligoxygakis et al., 1998, Ligoxygakis et al., 1998, Hemavathy et al., 1997, Jimenez and Ish-Horowicz, 1997, Preiss et al., 1997, Wurmbach and Preiss, 1997, de Celis et al., 1996, Fisher et al., 1996, Gigliani et al., 1996, Hartenstein et al., 1996, Heitzler et al., 1996, Rusch and Levine, 1996, Alifragis et al., 1995, Alifragis et al., 1995, Bang et al., 1995, Lecourtois and Schweisguth, 1995, Lecourtois and Schweisguth, 1995, Tepass and Hartenstein, 1995, Wurmbach et al., 1995, Gonzalez-Crespo and Levine, 1993, Tietze et al., 1993, Delidakis and Artavanis-Tsakonas, 1992, Fischer-Vize et al., 1992, Delidakis et al., 1991, Knust et al., 1991, Preiss et al., 1991, Rao et al., 1991, Schrons et al., 1991, Campos-Ortega and Knust, 1990, Campos-Ortega and Knust, 1990, Klambt et al., 1989, Knust et al., 1987)
                                Name Synonyms
                                E(spl) region transcript 7
                                (Ibrahim et al., 2013)
                                E(spl) region transcript m7
                                (Krejcí et al., 2009, Parrish et al., 2006)
                                E(spl)m7
                                (Monastirioti et al., 2010)
                                Enhancer of split m7
                                (Rice et al., 2020, Chandra and Vaessin, 2003)
                                Enhancer of split m7, helix-loop-helix
                                (Young and Marcotte, 2017)
                                Secondary FlyBase IDs
                                • FBgn0020009
                                • FBgn0020922
                                Datasets (0)
                                Study focus (0)
                                Experimental Role
                                Project
                                Project Type
                                Title
                                References (255)