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Gene Dmel\Bj1

General Information
Symbol	Dmel\Bj1	Species	D. melanogaster
Name	Bj1 protein	Annotation symbol	CG10480
Feature type	protein_coding_gene	FlyBase ID	FBgn0002638
Gene Model Status	Current	Stock availability	6 publicly available
Also Known As	RanGEF, RCC1
Genomic Location
Chromosome (arm)	3L	Recombination map
Cytogenetic map	65A1-65A1	Sequence location	3L:5,923,362..5,925,873 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Bj1 protein is referred to in FlyBase by the symbol Dmel\Bj1 (CG10480, FBgn0002638). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: chromatin binding. There is experimental evidence that it is involved in the biological process: central nervous system development; regulation of mitotic cell cycle; regulation of neurogenesis; regulation of nucleocytoplasmic transport; neurogenesis. 19 alleles are reported. The phenotypes of these alleles are annotated with: eye; intersegmental nerve; mesothoracic tergum; eye photoreceptor cell; ommatidium; EL neuron. It has 3 annotated transcripts and 3 annotated polypeptides. Protein features are: Regulator of chromosome condensation, RCC1; Regulator of chromosome condensation/beta-lactamase-inhibitor protein II. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of moderate expression. Peak expression observed within 00-12 hour embryonic stages, in adult female stages. Summary of FlyAtlas Anatomical Expression Data: Many larval and adult organs/tissues expressed at moderate levels. Expression at high levels in the following post-embryonic organs or tissues: larval central nervous system, adult ovary. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, adult Malpighian tubules, larval/adult fat body, larval/adult salivary gland, larval trachea, adult spermathecae, adult testis, larval/adult carcass. Comments on Affy2 ProbeSet: ProbeSet 1630166_s_at completely aligns to an exonic region common to each of the 3 FlyBase-annotated transcript isoforms of Bj1. Gene sequence location is 3L:5923362..5925873.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2012_01	References Makde et al., 2010, Nature 467(7315): 562--566 Sequence features BKN20724 HFA09684
FB2011_10	References Neumüller et al., 2011, Cell Stem Cell 8(5): 580--593
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 65A1-65A1   Limits computationally determined from genome sequence between P{PZ}vn10567 and P{PZ}loj04026
Experimentally Determined Cytological Location
Cytogenetic map Notes References 64F-64F     (Eggert et al., 1998) 64F-64F   (determined by in situ hybridisation)   (Frasch, 1991)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\Bj1 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Bj1-RA FBtr0077074  NM_079219   2365   547 Bj1-RB FBtr0077075  NM_168151   2199   547 Bj1-RC FBtr0077076  NM_168152   2140   547
Additional Transcript Data & Comments
Reported size (kB)	2.2 (northern blot) (Frasch, 1991)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Bj1-PA   FBpp0076782   58.9   547   8.06     NP_523943   AAF50726 Bj1-PB   FBpp0076783   58.9   547   8.06     NP_729118   AAF50727 Bj1-PC   FBpp0076784   58.9   547   8.06     NP_729119   AAN12235
Additional Polypeptide Data & Comments
Reported size (kDa)	547 (aa); 68 (kD) (Frasch, 1991) 68 (kD) (Ohtsubo et al., 1991)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Regulator of chromosome condensation, RCC1 (IPR000408) Regulator of chromosome condensation/beta-lactamase-inhibitor protein II (IPR009091)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA201925   AA202046   AA202412   AA202572   AA246416   AA246799   AA263792   AA263823   AA263867   AA264127   AA264354   AA264974   AA390302   AA391440   AA392124   AA392653   AA438687   AA439116   AA439527   AA440262   AA440520   AA441094   AA536321   AA536344   AA536574   AA536589   AA538702   AA538863   AA538929   AA539104   AA540125   AA540267   AA540374   AA541224   AA735561   AA802172   AA803831   AA816290   AA816319   AA816662   AA817289   AA817314   AA820231   AA820609   AA820733   AA820835   AA940797   AA940818   AA941005   AA941523   AA941582   AA941755   AA941891   AA942247   AA942517   AA942544   AA942593   AA942630   AA949206   AA949371   AA949476   AA950037   AA950095   AA950504   AA950900   AA951784   AA952016   AA952114   AA978747   AA978830   AA979112   AA979243   AA979494   AA979687   AA990869   AE014296 AAF50726   AE014296 AAF50727   AE014296 AAN12235   AI061708   AI061905   AI297714   AI455275   AI456253   AI456806   AI512048   AI512309   AI512311   AI512562   AI512849   AI514318   AI514493   AI514687   AI514929   AI515664   AI515717   AI516212   AI516795   AI518522   AI518563   AI519616   AI520420   AI520436   AI530992   AI533251   AI533673   AI542615   AI543418   AI546288   AQ073074   AY070540 AAL48011   BE975508   BE975812   BF498731   BF502043   BG635349   BI163146   BI163843   BI164887   BI165324   BI166193   BI166491   BI167260   BI167429   BI167837   BI168580   BI171513   BI213919   BI214063   BI214492   BI215702   BI216042   BI216503   BI228318   BI231771   BI232283   BI235103   BI238011   BI239663   BI241681   BI242218   BI354289   BI354378   BI356139   BI356339   BI358551   BI362307   BI364400   BI365987   BI366771   BI372067   BI482215   BI485899   BI564162   BI576052   BI577491   BI577492   BI578552   BI580481   BI584682   BI609492   BI626316   BI635454   BI635610   BI636903   BI637597   BI640516   BP554761   BQ102680   CK131969   CL527882   CO156807   CO177152   CO178753   CO268797   CO292438   CO293976   CO300102   CO308408   EC072409   EC079017   EC201121   EC201398   EC209749   EC224388   EC230081   EC230341   EC238200   EC243039   EC264903   ES690337   ES690348   ES690349   ES690363   ES690365   ES690368   ES690373   ES690396   ES692319   ES693181   ES693238   EV583699   EV593448   GH941547   GH943659   GH945003   GH945104   GH945968   GH950332   GH951032   GH951301   GH951815   GH952440   GH955375   GH958654   GH960395   GH961396   GH961997   GH962467   GH963335   GH964621   GH969983   GH976267   GH977175   GH977857   GH980704   GH982672   GH984477   X58530 CAA41417
UniProtKB/Swiss-Prot	P25171
UniProtKB/TrEMBL
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
No Assay Recorded Stage Tissue/Position (including subcellular localization) Reference embryonic stage | early     (Frasch, 1991) adult stage & oogenesis   nurse cell   (Frasch, 1991) in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage   neuroblast   (Frasch, 1991) adult stage & oogenesis   oocyte   (Frasch, 1991)
Additional Descriptive Data
	Bj1 transcripts are abundant in early embryos and adult females and are barely detectable at other developmental stages. Bj1 transcripts are strongly enriched in the prospective oocyte of young follicles and only low levels are present in nurse cells. At stage 10 of oogenesis, strong expression starts in the nurse cells and the transcripts are later transported to the oocyte. Bj1 transcripts are uniformly distributed in early embryos. In later embryos, transcripts persist only in neuroblasts and ganglion cells derived from them. (Frasch, 1991)
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
No Assay Recorded Stage Tissue/Position (including subcellular localization) Reference embryonic stage   presumptive embryonic/larval central nervous system   (Frasch, 1991) adult stage & oogenesis   nurse cell   (Frasch, 1991) immunolocalization Stage Tissue/Position (including subcellular localization) Reference embryonic stage   neuroblast   (Frasch, 1991)   • chromatin (Trieselmann and Wilde, 2002) Comment:interphase embryonic stage 1 -- 12   cell   • nucleus (Shi and Skeath, 2004) Comment:Bj1 is localized to all cell nuclei embryonic stage 13 -- 17   presumptive embryonic/larval central nervous system   • nucleus (Shi and Skeath, 2004) larval stage   embryonic/larval salivary gland   (Frasch, 1991) adult stage & oogenesis   oocyte   (Frasch, 1991)
Additional Descriptive Data
	Bj1 protein is found exclusively in nuclei in the oocyte and is predominantly localized to nuclei in early cleavage stage embryos. From the blastoderm stage onwards, Bj1 protein is exclusively nuclear during interphase. During mitosis, it becomes evenly distributed throughout the cells. It is found in all bands of polytene chromosomes and is absent from developmental puffs, heat-shock puffs and interbands. (Frasch, 1991) Bj1 (RCC1) protein wasassociated with chromatin throughout the cell cycle including during mitosis in methanol fixed embryos and as monitored by injected rhodamine labeled human RCC1 protein. (Shi and Skeath, 2004, Trieselmann and Wilde, 2002)
Marker for
Subcellular Localization
CV Term	nucleus nucleosome polytene chromosome chromatin (Frasch, 1991)
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0002638    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0002638 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of moderate expression. Peak expression observed within 00-12 hour embryonic stages, in adult female stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0002638 expression level Developmental Stage   Expression Level embryo 00-02hr    20132 embryo 02-04hr    31526 embryo 04-06hr    23749 embryo 06-08hr    17448 embryo 08-10hr    14238 embryo 10-12hr    8747 embryo 12-14hr    5494 embryo 14-16hr    6148 embryo 16-18hr    4668 embryo 18-20hr    2476 embryo 20-22hr    5781 embryo 22-24hr    4727 larva L1    2447 larva L2    2290 larva L3 12hr old    1897 larva L3 puffstage 1-2    1344 larva L3 puffstage 3-6    1742 larva L3 puffstage 7-9    1709 white prepupae new    1651 white prepupae 12hr    2819 white prepupae 24hr    2620 pupae 2d postWPP    1578 pupae 3d postWPP    1011 pupae 4d postWPP    1470 adult male 01day    1346 adult male 05day    1961 adult male 30day    1687 adult female 01day    6707 adult female 05day    10737 adult female 30day    11613 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (20132) embryo 02-04hr  (31526) embryo 04-06hr  (23749) embryo 06-08hr  (17448) embryo 08-10hr  (14238) embryo 10-12hr  (8747) embryo 12-14hr  (5494) embryo 14-16hr  (6148) embryo 16-18hr  (4668) embryo 18-20hr  (2476) embryo 20-22hr  (5781) embryo 22-24hr  (4727) larva L1  (2447) larva L2  (2290) larva L3 12hr old  (1897) larva L3 puffstage 1-2  (1344) larva L3 puffstage 3-6  (1742) larva L3 puffstage 7-9  (1709) white prepupae new  (1651) white prepupae 12hr  (2819) white prepupae 24hr  (2620) pupae 2d postWPP  (1578) pupae 3d postWPP  (1011) pupae 4d postWPP  (1470) adult male 01day  (1346) adult male 05day  (1961) adult male 30day  (1687) adult female 01day  (6707) adult female 05day  (10737) adult female 30day  (11613) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (20132) embryo 02-04hr  (31526) embryo 04-06hr  (23749) embryo 06-08hr  (17448) embryo 08-10hr  (14238) embryo 10-12hr  (8747) embryo 12-14hr  (5494) embryo 14-16hr  (6148) embryo 16-18hr  (4668) embryo 18-20hr  (2476) embryo 20-22hr  (5781) embryo 22-24hr  (4727) larva L1  (2447) larva L2  (2290) larva L3 12hr old  (1897) larva L3 puffstage 1-2    1344 larva L3 puffstage 3-6  (1742) larva L3 puffstage 7-9  (1709) white prepupae new  (1651) white prepupae 12hr  (2819) white prepupae 24hr  (2620) pupae 2d postWPP  (1578) pupae 3d postWPP    1011 pupae 4d postWPP  1470 adult male 01day    1346 adult male 05day  (1961) adult male 30day  (1687) adult female 01day  (6707) adult female 05day  (10737) adult female 30day  (11613) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr  (20132) embryo 02-04hr  (31526) embryo 04-06hr  (23749) embryo 06-08hr  (17448) embryo 08-10hr  (14238) embryo 10-12hr    8747 embryo 12-14hr    5494 embryo 14-16hr    6148 embryo 16-18hr    4668 embryo 18-20hr    2476 embryo 20-22hr    5781 embryo 22-24hr    4727 larva L1    2447 larva L2    2290 larva L3 12hr old    1897 larva L3 puffstage 1-2    1344 larva L3 puffstage 3-6    1742 larva L3 puffstage 7-9    1709 white prepupae new    1651 white prepupae 12hr    2819 white prepupae 24hr    2620 pupae 2d postWPP    1578 pupae 3d postWPP    1011 pupae 4d postWPP    1470 adult male 01day    1346 adult male 05day    1961 adult male 30day    1687 adult female 01day    6707 adult female 05day  10737 adult female 30day  (11613) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    20132 embryo 02-04hr    31526 embryo 04-06hr    23749 embryo 06-08hr    17448 embryo 08-10hr    14238 embryo 10-12hr    8747 embryo 12-14hr    5494 embryo 14-16hr    6148 embryo 16-18hr    4668 embryo 18-20hr    2476 embryo 20-22hr    5781 embryo 22-24hr    4727 larva L1    2447 larva L2    2290 larva L3 12hr old    1897 larva L3 puffstage 1-2    1344 larva L3 puffstage 3-6    1742 larva L3 puffstage 7-9    1709 white prepupae new    1651 white prepupae 12hr    2819 white prepupae 24hr    2620 pupae 2d postWPP    1578 pupae 3d postWPP    1011 pupae 4d postWPP    1470 adult male 01day    1346 adult male 05day    1961 adult male 30day    1687 adult female 01day    6707 adult female 05day    10737 adult female 30day    11613 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0002638 expression level Developmental Stage   Expression Level embryo 00-02hr    20132 embryo 02-04hr    31526 embryo 04-06hr    23749 embryo 06-08hr    17448 embryo 08-10hr    14238 embryo 10-12hr    8747 embryo 12-14hr    5494 embryo 14-16hr    6148 embryo 16-18hr    4668 embryo 18-20hr    2476 embryo 20-22hr    5781 embryo 22-24hr    4727 larva L1    2447 larva L2    2290 larva L3 12hr old    1897 larva L3 puffstage 1-2    1344 larva L3 puffstage 3-6    1742 larva L3 puffstage 7-9    1709 white prepupae new    1651 white prepupae 12hr    2819 white prepupae 24hr    2620 pupae 2d postWPP    1578 pupae 3d postWPP    1011 pupae 4d postWPP    1470 adult male 01day    1346 adult male 05day    1961 adult male 30day    1687 adult female 01day    6707 adult female 05day    10737 adult female 30day    11613 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (20132) embryo 02-04hr  (31526) embryo 04-06hr  (23749) embryo 06-08hr  (17448) embryo 08-10hr  (14238) embryo 10-12hr  (8747) embryo 12-14hr  (5494) embryo 14-16hr  (6148) embryo 16-18hr  (4668) embryo 18-20hr  (2476) embryo 20-22hr  (5781) embryo 22-24hr  (4727) larva L1  (2447) larva L2  (2290) larva L3 12hr old  (1897) larva L3 puffstage 1-2  (1344) larva L3 puffstage 3-6  (1742) larva L3 puffstage 7-9  (1709) white prepupae new  (1651) white prepupae 12hr  (2819) white prepupae 24hr  (2620) pupae 2d postWPP  (1578) pupae 3d postWPP  (1011) pupae 4d postWPP  (1470) adult male 01day  (1346) adult male 05day  (1961) adult male 30day  (1687) adult female 01day  (6707) adult female 05day  (10737) adult female 30day  (11613) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (20132) embryo 02-04hr  (31526) embryo 04-06hr  (23749) embryo 06-08hr  (17448) embryo 08-10hr  (14238) embryo 10-12hr  (8747) embryo 12-14hr  (5494) embryo 14-16hr  (6148) embryo 16-18hr  (4668) embryo 18-20hr  (2476) embryo 20-22hr  (5781) embryo 22-24hr  (4727) larva L1  2447 larva L2  2290 larva L3 12hr old  1897 larva L3 puffstage 1-2    1344 larva L3 puffstage 3-6  1742 larva L3 puffstage 7-9  1709 white prepupae new  1651 white prepupae 12hr  (2819) white prepupae 24hr  (2620) pupae 2d postWPP  1578 pupae 3d postWPP    1011 pupae 4d postWPP  1470 adult male 01day    1346 adult male 05day  1961 adult male 30day  1687 adult female 01day  (6707) adult female 05day  (10737) adult female 30day  (11613) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr  20132 embryo 02-04hr  (31526) embryo 04-06hr  (23749) embryo 06-08hr  17448 embryo 08-10hr  14238 embryo 10-12hr    8747 embryo 12-14hr    5494 embryo 14-16hr    6148 embryo 16-18hr    4668 embryo 18-20hr    2476 embryo 20-22hr    5781 embryo 22-24hr    4727 larva L1    2447 larva L2    2290 larva L3 12hr old    1897 larva L3 puffstage 1-2    1344 larva L3 puffstage 3-6    1742 larva L3 puffstage 7-9    1709 white prepupae new    1651 white prepupae 12hr    2819 white prepupae 24hr    2620 pupae 2d postWPP    1578 pupae 3d postWPP    1011 pupae 4d postWPP    1470 adult male 01day    1346 adult male 05day    1961 adult male 30day    1687 adult female 01day    6707 adult female 05day  10737 adult female 30day  11613 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    20132 embryo 02-04hr    31526 embryo 04-06hr    23749 embryo 06-08hr    17448 embryo 08-10hr    14238 embryo 10-12hr    8747 embryo 12-14hr    5494 embryo 14-16hr    6148 embryo 16-18hr    4668 embryo 18-20hr    2476 embryo 20-22hr    5781 embryo 22-24hr    4727 larva L1    2447 larva L2    2290 larva L3 12hr old    1897 larva L3 puffstage 1-2    1344 larva L3 puffstage 3-6    1742 larva L3 puffstage 7-9    1709 white prepupae new    1651 white prepupae 12hr    2819 white prepupae 24hr    2620 pupae 2d postWPP    1578 pupae 3d postWPP    1011 pupae 4d postWPP    1470 adult male 01day    1346 adult male 05day    1961 adult male 30day    1687 adult female 01day    6707 adult female 05day    10737 adult female 30day    11613 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0002638    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0002638 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Many larval and adult organs/tissues expressed at moderate levels. Expression at high levels in the following post-embryonic organs or tissues: larval central nervous system, adult ovary. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, adult Malpighian tubules, larval/adult fat body, larval/adult salivary gland, larval trachea, adult spermathecae, adult testis, larval/adult carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0002638 expression level Tissue   Expression Level Larval Central Nervous System    1079.575 Larval Midgut    188.9 Larval Hindgut    308 Larval Malpighian Tubules    97.4 Larval Fat Body    102.8 Larval Salivary Gland    427.8 Larval Trachea    312.225 Larval Carcass    430.5 Adult Head    137 Adult Eye    65.775 Adult Brain    228 Adult Thoracic-Abdominal Ganglion    206 Adult Crop    101.6 Adult Midgut    118.6 Adult Hindgut    109.1 Adult Malpighian Tubules    152.6 Adult Fat Body    169.2 Adult Salivary Gland    127.5 Adult Heart    51.225 Adult VirginFemale Spermatheca    175 Adult InseminatedFemale Spermatheca    157.5 Adult Ovary    1636.5 Adult Testis    389.6 Adult Male Accessory Gland    99.9 Adult Carcass    126.5 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System  (1079.575) Larval Midgut    188.9 Larval Hindgut    308 Larval Malpighian Tubules    97.4 Larval Fat Body    102.8 Larval Salivary Gland    427.8 Larval Trachea    312.225 Larval Carcass    430.5 Adult Head    137 Adult Eye    65.775 Adult Brain    228 Adult Thoracic-Abdominal Ganglion    206 Adult Crop    101.6 Adult Midgut    118.6 Adult Hindgut    109.1 Adult Malpighian Tubules    152.6 Adult Fat Body    169.2 Adult Salivary Gland    127.5 Adult Heart    51.225 Adult VirginFemale Spermatheca    175 Adult InseminatedFemale Spermatheca    157.5 Adult Ovary  (1636.5) Adult Testis    389.6 Adult Male Accessory Gland    99.9 Adult Carcass    126.5 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System  (1079.575) Larval Midgut    188.9 Larval Hindgut    308 Larval Malpighian Tubules    97.4 Larval Fat Body    102.8 Larval Salivary Gland    427.8 Larval Trachea    312.225 Larval Carcass    430.5 Adult Head    137 Adult Eye    65.775 Adult Brain    228 Adult Thoracic-Abdominal Ganglion    206 Adult Crop    101.6 Adult Midgut    118.6 Adult Hindgut    109.1 Adult Malpighian Tubules    152.6 Adult Fat Body    169.2 Adult Salivary Gland    127.5 Adult Heart    51.225 Adult VirginFemale Spermatheca    175 Adult InseminatedFemale Spermatheca    157.5 Adult Ovary  (1636.5) Adult Testis    389.6 Adult Male Accessory Gland    99.9 Adult Carcass    126.5 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    1079.575 Larval Midgut    188.9 Larval Hindgut    308 Larval Malpighian Tubules    97.4 Larval Fat Body    102.8 Larval Salivary Gland    427.8 Larval Trachea    312.225 Larval Carcass    430.5 Adult Head    137 Adult Eye    65.775 Adult Brain    228 Adult Thoracic-Abdominal Ganglion    206 Adult Crop    101.6 Adult Midgut    118.6 Adult Hindgut    109.1 Adult Malpighian Tubules    152.6 Adult Fat Body    169.2 Adult Salivary Gland    127.5 Adult Heart    51.225 Adult VirginFemale Spermatheca    175 Adult InseminatedFemale Spermatheca    157.5 Adult Ovary    1636.5 Adult Testis    389.6 Adult Male Accessory Gland    99.9 Adult Carcass    126.5 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0002638 expression level Tissue   Expression Level Larval Central Nervous System    1079.575 Larval Midgut    188.9 Larval Hindgut    308 Larval Malpighian Tubules    97.4 Larval Fat Body    102.8 Larval Salivary Gland    427.8 Larval Trachea    312.225 Larval Carcass    430.5 Adult Head    137 Adult Eye    65.775 Adult Brain    228 Adult Thoracic-Abdominal Ganglion    206 Adult Crop    101.6 Adult Midgut    118.6 Adult Hindgut    109.1 Adult Malpighian Tubules    152.6 Adult Fat Body    169.2 Adult Salivary Gland    127.5 Adult Heart    51.225 Adult VirginFemale Spermatheca    175 Adult InseminatedFemale Spermatheca    157.5 Adult Ovary    1636.5 Adult Testis    389.6 Adult Male Accessory Gland    99.9 Adult Carcass    126.5 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System  (1079.575) Larval Midgut    188.9 Larval Hindgut    308 Larval Malpighian Tubules    97.4 Larval Fat Body    102.8 Larval Salivary Gland    427.8 Larval Trachea    312.225 Larval Carcass    430.5 Adult Head    137 Adult Eye    65.775 Adult Brain    228 Adult Thoracic-Abdominal Ganglion    206 Adult Crop    101.6 Adult Midgut    118.6 Adult Hindgut    109.1 Adult Malpighian Tubules    152.6 Adult Fat Body    169.2 Adult Salivary Gland    127.5 Adult Heart    51.225 Adult VirginFemale Spermatheca    175 Adult InseminatedFemale Spermatheca    157.5 Adult Ovary  (1636.5) Adult Testis    389.6 Adult Male Accessory Gland    99.9 Adult Carcass    126.5 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System  1079.575 Larval Midgut    188.9 Larval Hindgut    308 Larval Malpighian Tubules    97.4 Larval Fat Body    102.8 Larval Salivary Gland    427.8 Larval Trachea    312.225 Larval Carcass    430.5 Adult Head    137 Adult Eye    65.775 Adult Brain    228 Adult Thoracic-Abdominal Ganglion    206 Adult Crop    101.6 Adult Midgut    118.6 Adult Hindgut    109.1 Adult Malpighian Tubules    152.6 Adult Fat Body    169.2 Adult Salivary Gland    127.5 Adult Heart    51.225 Adult VirginFemale Spermatheca    175 Adult InseminatedFemale Spermatheca    157.5 Adult Ovary  1636.5 Adult Testis    389.6 Adult Male Accessory Gland    99.9 Adult Carcass    126.5 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    1079.575 Larval Midgut    188.9 Larval Hindgut    308 Larval Malpighian Tubules    97.4 Larval Fat Body    102.8 Larval Salivary Gland    427.8 Larval Trachea    312.225 Larval Carcass    430.5 Adult Head    137 Adult Eye    65.775 Adult Brain    228 Adult Thoracic-Abdominal Ganglion    206 Adult Crop    101.6 Adult Midgut    118.6 Adult Hindgut    109.1 Adult Malpighian Tubules    152.6 Adult Fat Body    169.2 Adult Salivary Gland    127.5 Adult Heart    51.225 Adult VirginFemale Spermatheca    175 Adult InseminatedFemale Spermatheca    157.5 Adult Ovary    1636.5 Adult Testis    389.6 Adult Male Accessory Gland    99.9 Adult Carcass    126.5 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    137   NA  Eye    65.775   NA  Brain    228   1079.575  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    206   NA  Crop    101.6   188.9  Midgut    118.6   308  Hindgut    109.1   97.4  Malpighian Tubules    152.6   102.8  Fat Body    169.2   427.8  Salivary Gland    127.5   NA  Heart    51.225   312.225  Trachea    NA   NA  VirginFemale Spermatheca    175   NA  InseminatedFemale Spermatheca    157.5   NA  Ovary    1636.5   NA  Testis    389.6   NA  Male Accessory Gland    99.9   430.5  Carcass    126.5 modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_08
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0002638 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG10480-RA FlyExpress - Embryonic expression images (BDGP data) • Show all FlyExpress processed images for Bj1 Stages(s) 1-3 Stages(s) 7-8 Stages(s) 9-10 Stages(s) 11-12 Stages(s) 13-16
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele cell lethal | somatic clone Bj1unspecified lethal, with Scer\GAL41407 Bj1GD6989 lethal | germline clone Bj1unspecified semi-lethal | pupal stage, with Scer\GAL4pnr-MD237 Bj1GD6989 viable Bj1EY06262 Sterility Allele fertile Bj1EY06262 Other Phenotypes Allele neuroanatomy defective | larval stage, with Scer\GAL41407 Bj1GD6989 neuroanatomy defective | larval stage, with Scer\GAL4elav-C155 Bj1EP3630 visible, with Scer\GAL4pnr-MD237 Bj1GD6989 Phenotype manifest in Allele anterior fascicle & synapse, with Scer\GAL4elav-C155 Bj1EP3630 central nervous system | lateral Bj1FF32 Bj1UU92 Bj1VV179 Bj1XX138 central nervous system | lateral (with Df(3L)ZN47) Bj1FF32 Bj1UU92 Bj1VV179 Bj1XX138 EL neuron Bj1FF32 Bj1UU92 Bj1VV179 Bj1XX138 EL neuron (with Df(3L)ZN47) Bj1FF32 Bj1UU92 Bj1VV179 Bj1XX138 embryonic/larval neuroblast | larval stage, with Scer\GAL41407 Bj1GD6989 eye Bj1FF32 eye photoreceptor cell Bj1FF32 ganglion mother cell | larval stage, with Scer\GAL41407 Bj1GD6989 intersegmental nerve, with Scer\GAL4elav-C155 Bj1EP3630 mesothoracic tergum, with Scer\GAL4pnr-MD237 Bj1GD6989 ommatidium Bj1FF32
Classical Alleles ( 11 )
For All Classical Alleles Show
Allele of Bj1 Class Mutagen Stocks Known lesion Bj1CB-5068-3 1 -- Bj1EY06262 P-element activity 1 -- Bj1NP4610 1 -- Bj1837 0 Yes Bj1EP3630 P-element activity 0 Yes Bj1FF32 loss of function allele ethyl methanesulfonate 0 Yes Bj1OreR 0 Yes Bj1unspecified 0 -- Bj1UU92 loss of function allele ethyl methanesulfonate 0 Yes Bj1VV179 loss of function allele ethyl methanesulfonate 0 Yes Bj1XX138 loss of function allele ethyl methanesulfonate 0 Yes
Alleles Carried on Transgenic Constructs ( 8 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Bj1 Class Mutagen Stocks Known lesion Bj1GD6989 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes Bj1GL00485 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Bj1del.Scer\UAS.T:Hsap\MYC in vitro construct - regulatory fusion 0 -- Bj1fl.T:Zzzz\His6 in vitro construct 0 Yes Bj1KK100628 in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes Bj1Scer\UAS.cSa in vitro construct - regulatory fusion 0 Yes Bj1Scer\UAS.T:Avic\GFP-EGFP in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes Bj1βTub85D.PK in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(3L)Exel7210 (Ryder, 2004.4.26)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD6989} NA P{KK100628} NA P{TRiP.GL00485} NA P{UAS-Bj1.del.MYC} NA P{UAS-Bj1.S} NA characterization construct P{βTub85D-Bj1.K} NA
Insertions
	Type of insertions Name Expression data insertion of mobile activating element P{EP}Bj1EP3630 NA P{EPgy2}Bj1EY06262 NA insertion of enhancer trap binary system P{GawB}Bj1NP4610 No miscellaneous insertions P{RS3}Bj1CB-5068-3 NA
Gene Ontology: Function, Process & Cellular Component ( 11 unique terms )
Terms Based on Experimental Evidence ( 7 terms )
Molecular Function
CV term Evidence References
chromatin binding inferred from direct assay (assigned by UniProtKB) (Trieselmann and Wilde, 2002)
Biological Process
CV term Evidence References
central nervous system development inferred from direct assay (assigned by UniProtKB) (Frasch, 1991) neurogenesis inferred from mutant phenotype (Neumüller et al., 2011) regulation of mitotic cell cycle inferred from direct assay (assigned by UniProtKB) (Trieselmann and Wilde, 2002) regulation of neurogenesis inferred from mutant phenotype (Shi and Skeath, 2004) regulation of nucleocytoplasmic transport inferred from mutant phenotype (Shi and Skeath, 2004)
Cellular Component
CV term Evidence References
nucleus inferred from direct assay (assigned by UniProtKB) (Frasch, 1991)
Terms Based on Predictions or Assertions ( 6 terms )
Molecular Function
CV term Evidence References
chromatin binding inferred from sequence or structural similarity with EMBL:X12654 (FlyBase, 1992-) Ran guanyl-nucleotide exchange factor activity non-traceable author statement (Swiss-Prot Project Members, 1992.5.1)
Biological Process
CV term Evidence References
chromosome condensation inferred from sequence or structural similarity with EMBL:X12654 (FlyBase, 1992-) mitotic chromosome condensation non-traceable author statement (Swiss-Prot Project Members, 1992.5.1)
Cellular Component
CV term Evidence References
cytoplasm non-traceable author statement (Swiss-Prot Project Members, 1992.5.1) nucleus inferred from sequence or structural similarity with EMBL:X12654 (FlyBase, 1992-) non-traceable author statement (Swiss-Prot Project Members, 1992.5.1)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Bj1 allele Gene References Bj1FF32 W (Shi and Skeath, 2004) Bj1XX138 W (Shi and Skeath, 2004) Bj1βTub85D.PK RanGap (Kusano et al., 2001) unspecified ec (Gorski et al., 2000) rst (Gorski et al., 2000)
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 64129 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0002638 DroID - A comprehensive database of gene and protein interactions. • FBgn0002638 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 38669
Orthologs
Genome-wide drosophilid orthologs	Dana\GF10433 Dere\GG14100 Dgri\GH16887 Dmoj\GI12030 Dpse\GA10341 Dsec\GM13884 Dsim\GD13166 Dvir\GJ13299 Dwil\GK17526 Dyak\GE20522
Curated drosophilid orthologs	Dpse\GA10341
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL007799-PA Aedes aegypti (mosquito) AGAP003742-PA Anopheles gambiae (mosquito) XP_394158.2 Apis mellifera (honey bee) XP_001950480.1 Acyrthosiphon pisum (pea aphid) At5g63860.1 Arabidopsis thaliana (wall cress) 36131 Batrachochytrium dendrobatidis (chytrid fungus) 85599 Branchiostoma floridae (lancelet) XP_001893354.1 Brugia malayi (roundworm nematode) BGIBMGA000072-PA Bombyx mori (silk worm) ENSBTAP00000032002 Bos taurus (bovine) CAL0002697 Candida albicans (a form of yeast) CN16812 Caenorhabditis brenneri (small nematode) CBP34691 Caenorhabditis briggsae (nematode) CE03024 Caenorhabditis elegans (worm) ENSCAFP00000017322 Canis familiaris (dog) CAGL0J05346g Candida glabrata (haploid yeast) Chro.40154 Cryptosporidium hominis (obligate parasite) ENSCINP00000006300 Ciona intestinalis (sea squirt) cn06018 Cryptococcus neoformans (yeast-like fungus) cgd4_1350 Cryptosporidium parvum (protozoan parasite) CPIJ012355 Culex pipens (mosquito) ENSCPOP00000009041 Cavia porcellus (guinea pig) 179719 Chlamidomonas reinhardtii (green alga) RP00599 Caenorhabditis remanei (nematode) ENSCSAVP00000013593 Ciona savignyi (sedentary tunicate) 159495 Capitella spl (polychaete worm) DDB0235366 Dictyostelium discoideum (amoeba) DEHA2A04620g Debaryomyces Hansenii (yeast) 206077 Daphnia pulex (daphnia) ENSDARP00000054025 Danio rerio (zebra fish) ENSECAP00000015007 Equus caballus (horse) ENSGACP00000009725 Gymnopilus aculeatus (mushroom) ENSGALP00000026161 Gallus gallus (chicken) 76996 Hypsipyla robusta (cedar shoot borer) ENSP00000381934 Homo sapiens (human) ISCW010923-PA Ixodes scapularis (deer tick) KLLA0F06600g Kluyveromyces lactis (yeast) 178675 Lottia gigantea (owl limpet) 33844 Monocosta brevicollis (choanoflagellate) ENSMODP00000013651 Monodelphis domestica (gray opossum) ENSMMUP00000031118 Macaca mulatta (rhesus monkey) ENSMUSP00000030726 Mus musculus (house mouse) 237483 Nematostella vectensis (starlet anemone) XP_001603331.1 Nasonia vitripennis (wasp) ENSOANP00000001881 Ornithorynchus anatinus (platypus) ENSORLP00000011311 Oryzias latipes (japanese killifish) LOC_Os04g35570.1 Oryza sativa (asian rice) 16486 Ostreococcus tauri (green alga) MAL7P1.38 Plasmodium falciparum (protozoal parasite) PHUM003243-PA Pediculus humanus (human body louse) PP11823 Pristionchus pacificus (nematode) 195710 Physcomitrella patens (moss) ENSPPYP00000001894 Pongo pygmaeus (orangutan) 79889 Phytophthora ramorum (sudden oak death pathogen) 135771 Phytophthora sojae (root rot pathogen) 718641 Populus trichocarpa (black cottonwood) ENSPTRP00000054180 Pan troglodytes (chimpanzee) PVX_088110 Plasmodium vivax (protozoal parasite) ENSRNOP00000057833 Rattus norvegicus (norway rat) 5056646 Sorghum bicolor (sorghum) YGL097W Saccharomyces cerevisiae (budding yeast) Smp_076530 Schistosoma mansoni (trematode parasite) SPBC557.03c Schizosaccharomyces pombe (fission yeast) XP_001191815.1 Strongylocentrotus purpuratus (purple sea urchin) 58118 Trichoplax adhaerens (metazoa) TA17690 Theileria annulata (apicomplexan parasite) XP_970173.2 Tribolium castaneum (red flour beetle) ENSTNIP00000012542 Tetraodon nigroviridis (green spotted pufferfish) TP03_0677 Theileria parva (parasitic protozoan) 23315 Thalassiosira pseudonana (marine diatom) ENSTRUP00000035511 Takifugu rubripes (pufferfish Takifugu) 3684.m00086 Tetrahymena thermophila (ciliate protozoa) ENSXETP00000028419 Xenopus tropicalis (frog) YALI0A13299g Yarrowia lipolytica (nonconventional yeast) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB13629 NV15945 LH20922 FBgn0237835 FBgn0219525 FBgn0217864 FBgn0200525 FBgn0184888 FBgn0168815 JGI_V11_206077 FBgn0070399 FBgn0158958 FBgn0134787 FBgn0124358 FBgn0106362 FBgn0087474 CPIJ012355 BGIBMGA000072 ACYPI004648 GB16393 AGAP003742 AAEL007799 PHUM509300 GLEAN_03860 GLEAN_03861
Stocks & Reagents
Stocks Listed in FlyBase ( 6 )
Bloomington	16706 y1 w67c23; P{EPgy2}Bj1EY06262 36067 y1 sc* v1; P{TRiP.GL00485}attP40
Kyoto	123439 w1118; P{RS3}Bj1CB-5068-3 104713 w*; P{GawB}Bj1NP4610 / TM3, Sb1 Ser1
VDRC	v38389 w1118; P{GD6989}v38389 v38388 w1118; P{GD6989}v38388/CyO
Genomic Clones ( 2 )
	BACR01O19 BACR11A21 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 209 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	LD22520
Other clones	DPiM_LD22520
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	AT13194 AT17658 AT31909 GM03966 GM14377 GM19036 GM24141 LD01191 LD02584 LD03203 LD03652 LD04064 LD05395 LD06413 LD06955 LD07007 LD07391 LD07581 LD07789 LD11408 LD13014 LD13587 LD14907 LD16871 LD16909 LD17352 LD18289 LD18493 LD18603 LD19507 LD19701 LD19845 LD21071 LD21523 LD22553 LD23069 LD24424 LD24594 LD24743 LD25701 LD25785 LD25935 LD26349 LD26908 LD26953 LD28623 LD29176 LD29986 LD30321 LD31063 LD32505 LD32902 LD33377 LD33789 LD34969 LD36142 LD36266 LD36939 LD38062 LD38132 LD40576 LD40602 LD41019 LD41367 LD42008 LD42865 LD43685 LD44103 LD44470 LD44921 LD46563 LD47569 LD47826 LP12079 LP13094 RE02477 RE03359 RE04652 RE07605 RE07816 RE08319 RE09377 RE13308 RE19566 RE19766 RE20315 RE22291 RE22844 RE23652 RE24303 RE25829 RE28329 RE30913 RE34366 RE38806 RE46837 RE49496 RE51396 RE52375 RE57987 RE64873 RE69254 RE71179 RE72433 RE74678 RH23939 RH35890 SD01815 SD05009 SD05573 SD09033 SD10160 SD16818 SD17006 SD18747 SD19647 SD23413
Other clones	29778 30464 71758 75264 75441 154038 193469 528262 bs43f06 bs45d03 CK01.66C.B12 CK01.72C.H8 CK01.121B.F8 Dmel_dig_009717_0601_3547 Dmel_neb_003258_0606_2870 EK052638 EK057464 EK092756 EK177407 EK200163 EK205257 EK258038 EN09339 FGM231F01 LD01147 LD02713 LD05789 LD08606 LD10103 LD12494 LD14118 LD15134 LD15879 LD17335 LD18819 LD21877 LD23039 LD23339 LD23433 LD23735 LD26775 LD26823 LD27221 LD28015 LD28242 LD29022 LD29493 LD33601 LD34095 LD34243 LD39265 LD41175 LD44101 RE05187 RE06238 RE06634 RE36222 RE39494 RE42210 RE42456 RE45350 RE71178 RH14281 RH32535 RH66893 RP004028193 RP004098886 RP004144320 RP004154040 RP004162787 RP004165414 RP004173663 RP004197699 RP004218347 RP004223591 RP004234940 RP004236381 RP004238755 RP004248611 RP004265970 RP004276133 RP004300215 RP004323935 RP004432808 RP004501550 RP004515857 RP004525151 RP004528752 RP004535056 RP004546085
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0002638 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 38669
Antibody Information
	monoclonal (Frasch, 1991)
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: Bj1 CG10480 (Gabrielian, 1999.11) Source for identity of: Bj1 side-out (Shi, 2001.3.12)
Source for database merge of	Source for merge of: Bj1 inxs (Freeman et al., 2004)
Additional comments
Other Comments
	Bj1 regulates nucleocytoplasmic transport and neural differentiation. (Shi and Skeath, 2004) Alleles of Bj1 show general defects in lateral CNS development. (Shi and Skeath, 2002) Mutants show supernumerary pigment cells between ommatidia, evident in the adult as a rough eye due to a disruption of the normally precise ommatidial pattern. This phenotype results from a failure of programmed cell death in the retinal epithelium. (Gorski et al., 2000) The maternally expressed Bj1 gene product binds to chromatin to establish or maintain a proper higher order structure as a prerequisite for regulated gene expression. Disruption of the structure may cause both misexpression and default repression of genes. (Frasch, 1991)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_079219 NM_168151 NM_168152 RefSeq (Proteins) • NP_523943 NP_729118 NP_729119 DDBJ / EMBL / GenBank • AA817289 AAF50726 AAF50727 AAL48011 AAN12235 AI455275 AQ073074 AY070540 CAA41417 CL527882 X58530 Entrez Gene - A searchable database of RefSeq genes. • 38669 UniProtKB/Swiss-Prot • P25171
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Regulator of chromosome condensation, RCC1 (IPR000408) Regulator of chromosome condensation/beta-lactamase-inhibitor protein II (IPR009091)
Linkouts
	BioGRID - A database of protein and genetic interactions • 64129 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0002638 DroID - A comprehensive database of gene and protein interactions. • FBgn0002638 DRSC - Results from RNAi screens. • FBgn0002638 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0002638 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG10480-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0002638 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 38669 InParanoid A subset of ortholog calls from InParanoid. • AAEL007799-PA Aedes aegypti (mosquito) AGAP003742-PA Anopheles gambiae (mosquito) XP_394158.2 Apis mellifera (honey bee) XP_001950480.1 Acyrthosiphon pisum (pea aphid) At5g63860.1 Arabidopsis thaliana (wall cress) 36131 Batrachochytrium dendrobatidis (chytrid fungus) 85599 Branchiostoma floridae (lancelet) XP_001893354.1 Brugia malayi (roundworm nematode) BGIBMGA000072-PA Bombyx mori (silk worm) ENSBTAP00000032002 Bos taurus (bovine) CAL0002697 Candida albicans (a form of yeast) CN16812 Caenorhabditis brenneri (small nematode) CBP34691 Caenorhabditis briggsae (nematode) CE03024 Caenorhabditis elegans (worm) ENSCAFP00000017322 Canis familiaris (dog) CAGL0J05346g Candida glabrata (haploid yeast) Chro.40154 Cryptosporidium hominis (obligate parasite) ENSCINP00000006300 Ciona intestinalis (sea squirt) cn06018 Cryptococcus neoformans (yeast-like fungus) cgd4_1350 Cryptosporidium parvum (protozoan parasite) CPIJ012355 Culex pipens (mosquito) ENSCPOP00000009041 Cavia porcellus (guinea pig) 179719 Chlamidomonas reinhardtii (green alga) RP00599 Caenorhabditis remanei (nematode) ENSCSAVP00000013593 Ciona savignyi (sedentary tunicate) 159495 Capitella spl (polychaete worm) DDB0235366 Dictyostelium discoideum (amoeba) DEHA2A04620g Debaryomyces Hansenii (yeast) 206077 Daphnia pulex (daphnia) ENSDARP00000054025 Danio rerio (zebra fish) ENSECAP00000015007 Equus caballus (horse) ENSGACP00000009725 Gymnopilus aculeatus (mushroom) ENSGALP00000026161 Gallus gallus (chicken) 76996 Hypsipyla robusta (cedar shoot borer) ENSP00000381934 Homo sapiens (human) ISCW010923-PA Ixodes scapularis (deer tick) KLLA0F06600g Kluyveromyces lactis (yeast) 178675 Lottia gigantea (owl limpet) 33844 Monocosta brevicollis (choanoflagellate) ENSMODP00000013651 Monodelphis domestica (gray opossum) ENSMMUP00000031118 Macaca mulatta (rhesus monkey) ENSMUSP00000030726 Mus musculus (house mouse) 237483 Nematostella vectensis (starlet anemone) XP_001603331.1 Nasonia vitripennis (wasp) ENSOANP00000001881 Ornithorynchus anatinus (platypus) ENSORLP00000011311 Oryzias latipes (japanese killifish) LOC_Os04g35570.1 Oryza sativa (asian rice) 16486 Ostreococcus tauri (green alga) MAL7P1.38 Plasmodium falciparum (protozoal parasite) PHUM003243-PA Pediculus humanus (human body louse) PP11823 Pristionchus pacificus (nematode) 195710 Physcomitrella patens (moss) ENSPPYP00000001894 Pongo pygmaeus (orangutan) 79889 Phytophthora ramorum (sudden oak death pathogen) 135771 Phytophthora sojae (root rot pathogen) 718641 Populus trichocarpa (black cottonwood) ENSPTRP00000054180 Pan troglodytes (chimpanzee) PVX_088110 Plasmodium vivax (protozoal parasite) ENSRNOP00000057833 Rattus norvegicus (norway rat) 5056646 Sorghum bicolor (sorghum) YGL097W Saccharomyces cerevisiae (budding yeast) Smp_076530 Schistosoma mansoni (trematode parasite) SPBC557.03c Schizosaccharomyces pombe (fission yeast) XP_001191815.1 Strongylocentrotus purpuratus (purple sea urchin) 58118 Trichoplax adhaerens (metazoa) TA17690 Theileria annulata (apicomplexan parasite) XP_970173.2 Tribolium castaneum (red flour beetle) ENSTNIP00000012542 Tetraodon nigroviridis (green spotted pufferfish) TP03_0677 Theileria parva (parasitic protozoan) 23315 Thalassiosira pseudonana (marine diatom) ENSTRUP00000035511 Takifugu rubripes (pufferfish Takifugu) 3684.m00086 Tetrahymena thermophila (ciliate protozoa) ENSXETP00000028419 Xenopus tropicalis (frog) YALI0A13299g Yarrowia lipolytica (nonconventional yeast) InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 38669 modMine - Data generated by the modENCODE project. • FBgn0002638 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB13629 NV15945 LH20922 FBgn0237835 FBgn0219525 FBgn0217864 FBgn0200525 FBgn0184888 FBgn0168815 JGI_V11_206077 FBgn0070399 FBgn0158958 FBgn0134787 FBgn0124358 FBgn0106362 FBgn0087474 CPIJ012355 BGIBMGA000072 ACYPI004648 GB16393 AGAP003742 AAEL007799 PHUM509300 GLEAN_03860 GLEAN_03861
Synonyms & Secondary IDs ( 14 )
Reported As
Symbol Synonym	BJ1 (Eggert et al., 1999, Eggert et al., 1998, Bassett et al., 1997, Foe et al., 1993, Dasso, 1993, Eggert et al., 2004) Bj1 (Bakal et al., 2007, Doheny et al., 2008, Kwon et al., 2008, Mason and Goldfarb, 2009, Hofmann et al., 2010, Neumüller et al., 2011) CG10480 (Mason and Goldfarb, 2009, Keleman et al., 2009.8.5, Ni et al., 2011.7.19) CG18640 (Bj1) (Kraut et al., 2001) dRCC1 (Mason and Goldfarb, 2009) inxs (Gorski et al., 2000, ) RanGEF (Hawley, 2001, Johnson, 2002, Kusano et al., 2002, Kusano et al., 2001, Kusano et al., 2001, McLean et al., 2008, Kwon et al., 2008) RCC1 (Trieselmann and Wilde, 2002, Jang et al., 2007, Kwon et al., 2008, Makde et al., 2010) Rcc1 (Silverman-Gavrila and Wilde, 2006) sdt (Shi and Skeath, 2001)
Name Synonym	Bj1 protein   CG18640 (Bj1), RCC protein (Kraut et al., 2001) in excess (Gorski et al., 2000) side-out (Shi and Skeath, 2001)
Secondary FlyBase IDs
	FBgn0041146
References ( 57 )
Generate a list of	All references relating to this gene ( 57 )
List References by type	Research paper  ( 22 ) Supplementary material  ( 6 ) Review  ( 6 ) Personal communication to FlyBase  ( 5 ) Abstract  ( 9 ) FlyBase analysis  ( 2 ) Curated genome annotation  ( 2 ) Protein sequence record  ( 1 ) Computer file  ( 2 ) Automatic genome annotation  ( 1 )
Recent research papers ( 3 )
	Neumüller et al., 2011, Cell Stem Cell 8(5): 580--593 Genome-Wide Analysis of Self-Renewal in Drosophila Neural Stem Cells by Transgenic RNAi. [FBrf0213621] Hofmann et al., 2010, Chromosome Res. 18(3): 307--324 The winged-helix transcription factor JUMU regulates development, nucleolus morphology and function, and chromatin organization of Drosophila melanogaster. [FBrf0210558] Makde et al., 2010, Nature 467(7315): 562--566 Structure of RCC1 chromatin factor bound to the nucleosome core particle. [FBrf0211950] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2010 Show reviews ...