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General Information
Symbol
Dmel\mam
Species
D. melanogaster
Name
mastermind
Annotation Symbol
CG8118
Feature Type
FlyBase ID
FBgn0002643
Gene Model Status
Stock Availability
Gene Snapshot
mastermind (mam) encodes a transcriptional coactivator that functions in the Notch signaling pathway. It regulates gene expression by interacting with the intracellular domain of the product of N, which is produced upon receptor activation. [Date last reviewed: 2019-03-14]
Also Known As
N-2G
Key Links
Genomic Location
Cytogenetic map
Sequence location
2R:13,991,203..14,060,356 [+]
Recombination map
2-68
Sequence
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
Function
GO Summary Ribbons
Protein Family (UniProt)
Belongs to the mastermind family. (P21519)
Molecular Function (GO)
[Detailed GO annotations]
Experimental Evidence
-
Predictions / Assertions
Summaries
Pathway (FlyBase)
Notch Signaling Pathway Core Components -
The Notch receptor signaling pathway is activated by the binding of the transmembrane receptor Notch (N) to transmembrane ligands, Dl or Ser, presented on adjacent cells. This results in the proteolytic cleavage of N, releasing the intracellular domain (NICD). NICD translocates into the nucleus, interacting with Su(H) and mam to form a transcription complex, which up-regulates transcription of Notch-responsive genes. (Adapted from FBrf0225731 and FBrf0192604). Core pathway components are required for signaling from the sending cell and response in the receiving cell.
Gene Group (FlyBase)
CSL-NOTCH-MASTERMIND TRANSCRIPTION FACTOR COMPLEX -
The CSL-Notch-Mastermind transcription factor complex consisting of the CSL protein, Su(H), and mastermind (mam) protein, in complex with Notch intracellular domain (generated by ligand-stimulated N-cleavage), up-regulates transcription of Notch-responsive genes. (Adapted from FBrf0232880).
Protein Function (UniProtKB)
May have a regulatory function possibly in association with the Notch gene product.
(UniProt, P21519)
Phenotypic Description (Red Book; Lindsley and Zimm 1992)
mam: master mind (J.C. Hall)
Homozygous embryonic lethal; embryos display neural hyperplasia with compensatory epidermal hypoplasia; caused by failure of most ventral ectodermal cells to differentiate as epidermal cells rather than neuroblasts, as seen in N, amx, bib, neu, Dl, and E(spl); mam tends to have less extreme neural hyperplasia than mutants at the other neurogenic loci. A similar diversion of cells from epidermigenic into neurogenic pathways seen to generate supernumerary peripheral nerve cells (Hartenstein and Campos-Ortega, 1986, Roux's Arch. Dev. Biol. 195: 210-21 (fig.)]. When mam expressed in female germ cells and the ensuing embryos, neural hyperplasia is enhanced, but mam+ embryos from oocytes are normal [Jimenez and Campos Ortega, 1982, Roux's Arch. Dev. Biol. 191: 1901-201 (fig.)]. Homozygous clones in the eye display irregular ommatidial pattern characterized by lack of interommatidial bristles, enlarged facets with supernumerary retinular cells and reduced numbers of pigment cells; in the cuticle, clones homozygous for mam2 are devoid of bristles [Dietrich and Campos-Ortega, 1984, J. Neurogenet. 1: 315-32 (fig.)]. mam1 (formerly N-2G) heterozygotes occasionally exhibit apical wing nicking; not recorded for other alleles. Phenotype of homozygotes for null allele reduced by duplications for normal alleles of other neurogenic loci, N, neu, Dl, E(spl), and H, but not amx or bib (de la Concha, Dietrich, Weigel, and Campos-Ortega, 1988, Genetics 118: 499-508).
Summary (Interactive Fly)
novel protein that physically interacts with Suppressor of Hairless and the intracellular domain of Notch that is produced upon receptor activation - functions as a transcriptional coactivator for Notch signaling
Gene Model and Products
Number of Transcripts
4
Number of Unique Polypeptides
2

Please see the GBrowse view of Dmel\mam or the JBrowse view of Dmel\mam for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model
Low-frequency RNA-Seq exon junction(s) not annotated.
Gene model reviewed during 5.50
Sequence Ontology: Class of Gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
FBtr0087596
6308
1594
FBtr0087597
7590
1594
FBtr0087598
1941
433
FBtr0339956
7884
1594
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
FBpp0086722
167.3
1594
8.19
FBpp0086723
167.3
1594
8.19
FBpp0086724
44.0
433
5.00
FBpp0308978
167.3
1594
8.19
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

1594 aa isoforms: mam-PA, mam-PB, mam-PD
Additional Polypeptide Data and Comments
Reported size (kDa)
1596 (aa); 167 (kD predicted)
Comments
External Data
Domain
The protein has many AA homopolymeric domains: 21 poly-Gln runs (from 5 to 16 AA in length), 4 poly-Gly (6 to 10 AA), 3 poly-Asn (3 X 5 AA), 1 poly-Ala (10 AA) and 1 poly-Thr (5 AA) runs.
(UniProt, P21519)
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\mam using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Gene Ontology (25 terms)
Molecular Function (1 term)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
inferred from electronic annotation with InterPro:IPR019082
(assigned by InterPro )
Biological Process (17 terms)
Terms Based on Experimental Evidence (14 terms)
CV Term
Evidence
References
inferred from mutant phenotype
inferred from mutant phenotype
inferred from mutant phenotype
inferred from mutant phenotype
inferred from genetic interaction with FLYBASE:Dl; FB:FBgn0000463
inferred from direct assay
inferred from genetic interaction with FLYBASE:dx; FB:FBgn0000524
inferred from mutant phenotype
inferred from mutant phenotype
Terms Based on Predictions or Assertions (3 terms)
CV Term
Evidence
References
inferred from biological aspect of ancestor with PANTHER:PTN001046424
(assigned by GO_Central )
inferred from biological aspect of ancestor with PANTHER:PTN001046424
(assigned by GO_Central )
traceable author statement
Cellular Component (7 terms)
Terms Based on Experimental Evidence (4 terms)
CV Term
Evidence
References
Terms Based on Predictions or Assertions (4 terms)
CV Term
Evidence
References
inferred from biological aspect of ancestor with PANTHER:PTN001046424
(assigned by GO_Central )
inferred from biological aspect of ancestor with PANTHER:PTN001046424
(assigned by GO_Central )
inferred from electronic annotation with InterPro:IPR019082
(assigned by InterPro )
inferred from biological aspect of ancestor with PANTHER:PTN001046424
(assigned by GO_Central )
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
northern blot
Stage
Tissue/Position (including subcellular localization)
Reference

Comment: reference states 0-2 hr AEL

Comment: reference states 2-16 hr AEL

Comment: reference states 8-16 hr AEL

radioisotope in situ
Stage
Tissue/Position (including subcellular localization)
Reference
organism | ubiquitous

Comment: reference states 5 hr AEL

embryonic/larval brain

Comment: reference states 16 hr AEL

ventral nerve cord

Comment: reference states 16 hr AEL

Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
immunolocalization
Stage
Tissue/Position (including subcellular localization)
Reference
Additional Descriptive Data
The nuclear localization of mam protein is consistent with its proposed role in gene regulation. Early in embryogenesis, mam protein shows nuclear, punctate localization. Immunohistochemical studies show that mam protein binds to more than 100 locations on polytene chromosomes, some of which colocalize with a subset of RNA polymerase and gro protein binding sites.
The pattern of mam protein localization is comparable to that of mam transcript. During gastrulation, the highest levels of mam protein are found in the ventral furrow, although expression is also seen in the cephalic furrow. Late in gastrulation, mam protein accumulates in the mesoderm and in the midgut primordia. At the completion of gastrulation, there are high levels of mam protein in the mesectoderm, the neurectoderm, as well as in the midgut primordia and the cephalic furrow.
Marker for
 
Subcellular Localization
CV Term
Evidence
References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\mam in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
Alleles, Insertions, and Transgenic Constructs
Classical and Insertion Alleles ( 190 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 14 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of mam
Transgenic constructs containing regulatory region of mam
Deletions and Duplications ( 51 )
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
Sterility
Allele
Other Phenotypes
Allele
Phenotype manifest in
Allele
anterior fascicle & synapse | supernumerary, with Scer\GAL4elav-C155
cuticle & macrochaeta | somatic clone
embryonic hypopharynx & epidermis
embryonic labial segment & embryonic epidermis
embryonic labral segment & embryonic epidermis
embryonic maxillary segment & embryonic epidermis
Orthologs
Human Orthologs (via DIOPT v7.1)
Homo sapiens (Human) (3)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Alignment
Complementation?
Transgene?
2 of 15
Yes
Yes
1 of 15
No
Yes
1 of 15
No
Yes
Model Organism Orthologs (via DIOPT v7.1)
Mus musculus (laboratory mouse) (2)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Alignment
Complementation?
Transgene?
2 of 15
Yes
Yes
1 of 15
No
Yes
Rattus norvegicus (Norway rat) (2)
2 of 13
Yes
Yes
1 of 13
No
Yes
Xenopus tropicalis (Western clawed frog) (3)
2 of 12
Yes
Yes
1 of 12
No
Yes
1 of 12
No
Yes
Danio rerio (Zebrafish) (3)
2 of 15
Yes
Yes
1 of 15
No
Yes
1 of 15
No
No
Caenorhabditis elegans (Nematode, roundworm) (0)
No records found.
Arabidopsis thaliana (thale-cress) (1)
1 of 9
Yes
No
Saccharomyces cerevisiae (Brewer's yeast) (0)
No records found.
Schizosaccharomyces pombe (Fission yeast) (0)
No records found.
Orthologs in Drosophila Species (via OrthoDB v9.1) ( EOG09190AW0 )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila melanogaster
fruit fly
Drosophila suzukii
Spotted wing Drosophila
Drosophila simulans
Drosophila sechellia
Drosophila erecta
Drosophila yakuba
Drosophila ananassae
Drosophila pseudoobscura pseudoobscura
Drosophila persimilis
Drosophila willistoni
Drosophila virilis
Drosophila mojavensis
Drosophila grimshawi
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG091503UK )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Glossina morsitans
Tsetse fly
Lucilia cuprina
Australian sheep blowfly
Mayetiola destructor
Hessian fly
Mayetiola destructor
Hessian fly
Mayetiola destructor
Hessian fly
Mayetiola destructor
Hessian fly
Aedes aegypti
Yellow fever mosquito
Anopheles gambiae
Malaria mosquito
Culex quinquefasciatus
Southern house mosquito
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W03MM )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Dendroctonus ponderosae
Mountain pine beetle
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( None identified )
No non-Insect Arthropod orthologies identified
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( None identified )
No non-Arthropod Metazoa orthologies identified
Paralogs
Paralogs (via DIOPT v7.1)
Drosophila melanogaster (Fruit fly) (0)
No records found.
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Model Summary Ribbon
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 0 )
    Human Ortholog
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 2 )
    Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
     
    Disease Associations of Human Orthologs (via DIOPT v7.1 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    Functional Complementation Data
    Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
    Interactions
    Summary of Physical Interactions
    Summary of Genetic Interactions
    esyN Network Diagram
    esyN Network Key:
    Suppression
    Enhancement

    Please look at the allele data for full details of the genetic interactions
    Starting gene(s)
    Interaction type
    Interacting gene(s)
    Reference
    Starting gene(s)
    Interaction type
    Interacting gene(s)
    Reference
    External Data
    Linkouts
    BioGRID - A database of protein and genetic interactions.
    DroID - A comprehensive database of gene and protein interactions.
    InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
    MIST (genetic) - An integrated Molecular Interaction Database
    MIST (protein-protein) - An integrated Molecular Interaction Database
    Pathways
    Gene Group - Pathway Membership (FlyBase)
    Notch Signaling Pathway Core Components -
    The Notch receptor signaling pathway is activated by the binding of the transmembrane receptor Notch (N) to transmembrane ligands, Dl or Ser, presented on adjacent cells. This results in the proteolytic cleavage of N, releasing the intracellular domain (NICD). NICD translocates into the nucleus, interacting with Su(H) and mam to form a transcription complex, which up-regulates transcription of Notch-responsive genes. (Adapted from FBrf0225731 and FBrf0192604). Core pathway components are required for signaling from the sending cell and response in the receiving cell.
    External Data
    Linkouts
    KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.
    SignaLink - A signaling pathway resource with multi-layered regulatory networks.
    Genomic Location and Detailed Mapping Data
    Chromosome (arm)
    2R
    Recombination map
    2-68
    Cytogenetic map
    Sequence location
    2R:13,991,203..14,060,356 [+]
    FlyBase Computed Cytological Location
    Cytogenetic map
    Evidence for location
    50C23-50D3
    Limits computationally determined from genome sequence between P{lacW}Cp1k15819&P{EP}CG6701EP2054 and P{lacW}mamk05821
    Experimentally Determined Cytological Location
    Cytogenetic map
    Notes
    References
    50D1-50D2
    (determined by in situ hybridisation)
    50C20-50C23
    (determined by in situ hybridisation)
    50C20-50C21
    50C22--23
    50C-50D
    (determined by in situ hybridisation)
    50C11-50D4
    (determined by in situ hybridisation)
    Experimentally Determined Recombination Data
    Right of (cM)
    Notes
    Determined by deletion mapping.
    Stocks and Reagents
    Stocks (59)
    Genomic Clones (58)
    cDNA Clones (59)
     

    Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

    cDNA clones, fully sequences
    BDGP DGC clones
    Other clones
    Drosophila Genomics Resource Center cDNA clones

    For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

    cDNA Clones, End Sequenced (ESTs)
    BDGP DGC clones
    RNAi and Array Information
    Linkouts
    DRSC - Results frm RNAi screens
    GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
    Antibody Information
    Laboratory Generated Antibodies
     
    monoclonal, polyclonal
    Commercially Available Antibodies
     
    Other Information
    Relationship to Other Genes
    Source for database identify of
    Source for database merge of
    Additional comments
    Other Comments
    mam is required for normal follicle stem cell maintenance in the ovary, but this function does not act through its known role in the N signalling pathway.
    The N signaling pathway is important for the formation and maintenance of the germline stem cell niche in the ovary.
    RNAi generated by PCR using primers directed to this gene causes a cell growth and viability phenotype when assayed in Kc167 and S2R+ cells.
    mam acts downstream of N to specify neuronal cell fates in the embryonic central nervous system.
    Five EMS-induced alleles have been isolated that suppress the macrochaetae, microchaetae and wing vein phenotypes of NAx-16, and the lethality of NAx-9/NAx-E2.
    2 alleles of mam have been isolated in a genetic screen for autosomal mutations that produce blisters in somatic wing clones.
    mam protein is widely expressed during embryonic and postembryonic development. Within salivary glands mam protein binds to over 100 polytene chromosome sites. Comparison of mams basic domain sequence to known proteins suggest that it may be distantly related to a subset of the leucine zipper class of transcription factors.
    Chi, but not mam, modulates expression of a gypsy insertion into Ubx. Chi and mam regulate ct alleles lacking gypsy insertions. sd, mam and Chi cooperate synergistically to regulate ct expression.
    mam transcription is highly conserved in D.melanogaster and D.virilis. Results also identify an unusual perinuclear distribution of RNA.
    Mutations (unspecified) enhance the rough eye phenotype of SerTM.sev.T:VSV\G and DlTM.sev flies.
    Variation of a microsatellite within the mam locus has been studied in North American populations of D.melanogaster.
    Mutations at fs(1)Yb show genetic interactions with the N group of neurogenic genes.
    Mutations can act as dominant modifiers of the activated N eye phenotype (FBrf0064452).
    Su(H) shows allele specific interactions with N, Dl, dx and mam.
    mam is a neurogenic gene required initially to ensure the correct number of PNS precursors. mam continues to be required in the peripheral ectoderm, possibly for maintenance of the commitment to an epidermal fate.
    NM1 defines a new class of Notch allele: similarity with and lack of specificity of interaction of N- and NM1 with H, mam, gro and E(spl) suggest that the NM1 effect is due to modification in the intracellular signalling of the activated N receptor.
    The embryonic phenotype of neurogenic mutations was examined in most tissues using Ecol\lacZ enhancer trap lines. All alleles examined show defects in many organs from all three germ layers. At least for ectodermally and endodermally derived tissues, neurogenic gene function is primarily involved in interactions among cells that need to acquire or maintain an epithelial phenotype.
    The expression of mam RNA and protein during embryogenesis (up to the completion of gastrulation) has been studied.
    mam is needed for proper mesoderm differentiation prior to the onset of nau expression: mutant alleles cause hypertrophy in nau expressing cells.
    The genomic organisation of Dvir\mam and D.melanogaster mam is similar.
    Mutations of mam, bib and neur in an heterozygous condition had no effect on the expression of NAx-59d or NAx-59b except when coupled in cis with Nfa-g. The neurogenic mutations suppress the wing venation phenotype of N.
    mam alleles act as enhancers of spl alleles of N.
    mam has been sequenced and its expression pattern analysed.
    An extra wild type copy of mam, in combination with dxENU, causes some pupal lethality, escapers have small eyes.
    Analysis of N and mam mutant combinations reveals that reduction of the wild type number of mam was capable of interferring with the mechanism underlying negative complementation in a manner that was not restricted to specific Abruptex combinations.
    Both neur and mam serve as hotspots for insertion of P{lacW} enhancer trap elements.
    Neural hyperplasia, caused by mutations in mam, can be prevented by the presence of another neurogenic mutation.
    H2 causes reduction of neural hyperplasia due to homozygosity for mam- alleles.
    Regions of mam cross-hybridize to the opa sequence.
    mam has been molecularly cloned.
    Homozygous embryonic lethal; embryos display neural hyperplasia with compensatory epidermal hypoplasia; caused by failure of most ventral ectodermal cells to differentiate as epidermal cells rather than neuroblasts, as seen in N, amx, bib, neu, Dl, and E(spl); mam tends to have less extreme neural hyperplasia than mutants at the other neurogenic loci. A similar diversion of cells from epidermigenic into neurogenic pathways seen to generate supernumerary peripheral nerve cells (Hartenstein and Campos-Ortega, 1986). When mam expressed in female germ cells and the ensuing embryos, neural hyperplasia is enhanced, but mam+ embryos from oocytes are normal (Jimenez and Campos Ortega, 1982). Homozygous clones in the eye display irregular ommatidial pattern characterized by lack of interommatidial bristles, enlarged facets with supernumerary retinular cells and reduced numbers of pigment cells; in the cuticle, clones homozygous for mam2 are devoid of bristles (Dietrich and Campos-Ortega, 1984). mam1 (formerly N-2G) heterozygotes occasionally exhibit apical wing nicking; not recorded for other alleles. Phenotype of homozygotes for null allele reduced by duplications for normal alleles of other neurogenic loci, N, neu, Dl, E(spl) and H, but not amx or bib (de la Concha et al., 1988).
    Origin and Etymology
    Discoverer
    Etymology
    Identification
    External Crossreferences and Linkouts ( 102 )
    Sequence Crossreferences
    NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
    GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
    RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
    UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
    UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
    Other crossreferences
    Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
    Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
    Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
    Flygut - An atlas of the Drosophila adult midgut
    GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
    InterPro - A database of protein families, domains and functional sites
    KEGG Genes - Molecular building blocks of life in the genomic space.
    KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.
    modMine - A data warehouse for the modENCODE project
    SignaLink - A signaling pathway resource with multi-layered regulatory networks.
    Linkouts
    ApoDroso - Functional genomic database for photoreceptor development, survival and function
    BioGRID - A database of protein and genetic interactions.
    DPiM - Drosophila Protein interaction map
    DroID - A comprehensive database of gene and protein interactions.
    DRSC - Results frm RNAi screens
    FLIGHT - Cell culture data for RNAi and other high-throughput technologies
    FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
    FlyMine - An integrated database for Drosophila genomics
    Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
    InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
    KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.
    MIST (genetic) - An integrated Molecular Interaction Database
    MIST (protein-protein) - An integrated Molecular Interaction Database
    Synonyms and Secondary IDs (16)
    Reported As
    Symbol Synonym
    l(2)03505
    l(2)04615
    mam
    (Bischof et al., 2018, Gomez-Lamarca et al., 2018, Lee et al., 2018, Portela et al., 2018, Salazar and Yamamoto, 2018, Schwarz et al., 2018, Bhattacharya et al., 2017, Liu and Jin, 2017, Morimoto et al., 2016, Xu et al., 2016, Arya et al., 2015, Bivik et al., 2015, Gene Disruption Project members, 2015-, Jia et al., 2015, Kidd et al., 2015, Portela et al., 2015, Spratford and Kumar, 2015, Surabhi et al., 2015, Ashwal-Fluss et al., 2014, Galindo et al., 2014, Huang and Kalderon, 2014, Parsons et al., 2014, Rhee et al., 2014, Singari et al., 2014, de Celis et al., 2013.9.11, Ghezzi et al., 2013, Joo et al., 2013, Kwon et al., 2013, Müller et al., 2013, Perea et al., 2013, Webber et al., 2013, Yu et al., 2013, Japanese National Institute of Genetics, 2012.5.21, Murray et al., 2012, Paik et al., 2012, Zacharioudaki et al., 2012, Bhattacharya and Baker, 2011, Carreira et al., 2011, Dworkin et al., 2011, O'Keefe et al., 2011, Zhang et al., 2011, Aerts et al., 2010, Cunha et al., 2010, Houalla et al., 2010, Kong et al., 2010, Monastirioti et al., 2010, Mourikis et al., 2010, Richardson and Pichaud, 2010, Ayroles et al., 2009, Bejarano and Milán, 2009, Bhattacharya and Baker, 2009, Debat et al., 2009, Parks and Muskavitch, 2009.2.3, Sellin et al., 2009, Southall and Brand, 2009, Vied and Kalderon, 2009, Chen et al., 2008, Herranz et al., 2008, Mensch et al., 2008, Pierre et al., 2008, Spresser et al., 2008, Vied and Kalderon, 2008, Bejarano et al., 2007, Beltran et al., 2007, Christensen et al., 2007.10.29, Endo et al., 2007, Junion et al., 2007, Kankel et al., 2007, Luque and Milan, 2007, Minidorff et al., 2007, Minidorff et al., 2007, Reiter et al., 2007, Song et al., 2007, Tao et al., 2007, Vied and Kalderon, 2007, Wang and Lin, 2007, Zeitlinger et al., 2007, Zeitouni et al., 2007, Albrecht et al., 2006, Alexander et al., 2006, Choksi et al., 2006, Dworkin and Gibson, 2006, Dworkin and Gibson., 2006, Garces and Thor, 2006, Gause et al., 2006, Herranz et al., 2006, Molnar et al., 2006, Sandmann et al., 2006, Macdonald and Long, 2005, Lindsley and Zimm, 1992)
    Secondary FlyBase IDs
    • FBgn0010581
    • FBgn0026797
    Datasets (0)
    Study focus (0)
    Experimental Role
    Project
    Project Type
    Title
    References (389)