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Gene Dmel\mei-218

General Information
Symbol	Dmel\mei-218	Species	D. melanogaster
Name	meiotic 218	Annotation symbol	CG8923
Feature type	protein_coding_gene	FlyBase ID	FBgn0002709
Gene Model Status	Current	Stock availability	6 publicly available
Genomic Location
Chromosome (arm)	X	Recombination map
Cytogenetic map	15E5-15E5	Sequence location	X:17,030,018..17,037,029 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene meiotic 218 is referred to in FlyBase by the symbol Dmel\mei-218 (CG8923, FBgn0002709). It is a protein_coding_gene from Drosophila melanogaster. Its molecular function is unknown. There is experimental evidence that it is involved in the biological process: female meiosis chromosome segregation; reciprocal meiotic recombination. 21 alleles are reported. The phenotypes of these alleles are annotated with: oocyte; cell cycle. It has 4 annotated transcripts and 4 annotated polypeptides. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of very low expression. Peak expression observed in adult male stages. This gene is annotated by FlyBase as a dicistronic gene, meaning that some or all of its transcripts encode two or more polypeptide-coding open reading frames (ORFs) , with each ORF assigned to a different gene. The distribution of RNA-Seq coverage data amongst the different encoded genes cannot be determined. Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: adult testis. Comments on Affy2 ProbeSet: ProbeSet 1626387_s_at aligns to a genomic region shared by exons of 2 FlyBase-annotated genes; hence it is impossible to interpret the expression pattern and levels of mei-218 expression signal. See the GBrowse view of mei-218 to determine the overlapping gene(s). Gene sequence location is X:17030018..17037029.
User Contributed Data
	Beta version, feedback welcome
Phenotypic Description from the Red Book (Lindsley & Zimm 1992)
Gene/Allele symbols may differ from current usage	mei-218 (R.S. Hawley) Females homozygous for mei-218 exhibit reduced levels of meiotic exchange. The residual exchanges are distributed such that the probability of euchromatic exchange becomes more nearly proportional to the polytene-chromosome length (Baker and Carpenter, 1972; Carpenter and Sandler, 1974; Baker and Hall, 1976). This relaxation of the normal constraints on the distribution of euchromatic exchange is clearly demonstrated by the ability of mei-218 females to allow exchange between the normally achiasmate fourth chromosomes (Sandler and Szauter, 1978). mei-218 does not, however, permit exchanges to occur in heterochromatic intervals (Carpenter and Baker, 1982). Ultrastructural analysis of pachytene in mei-218 and mei-2186-7 females demonstrates a reduced number of late recombination nodules (to about 8% of normal), which are distributed in a fashion that parallels the residual exchange events (Carpenter, 1979, 1989). Many of the nodules which are observed are morphologically abnormal. There is also some evidence that early recombination nodules may be either fewer in number or more ephemeral in mei-218 females (Carpenter, 1989). Although mei-218 alleles reduce the frequency of reciprocal meiotic exchange, the absolute frequency of gene conversion at the rosy locus is two-fold elevated relative to wild-type controls (Carpenter, 1982, 1984). Moreover, co-conversion distances are shorter than those recovered from controls or from mei-9 females (Carpenter, 1984). Thus the function of this locus is required for the generation of reciprocal exchanges and not for gene conversion (Carpenter, 1984). The reduced levels of reciprocal exchange which are characteristic of mei-218 females allow for high frequencies of meiotic loss and nondisjunction (see Baker and Hall, 1976). Nondisjunction occurs at the first meiotic division and only nonexchange chromosomes nondisjoin (Carpenter and Sandler, 1974). All assays for an effect of mei-218 on mitotic chromosome behavior in males or on somatic chromosome behavior are negative (Baker and Carpenter, 1972; Baker et al., 1978; Lutken and Baker, 1979; Gatti, 1979).
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 15E5-15E5   Limits computationally determined from genome sequence between P{EP}EP1337 and P{EP}bazEP1446
Experimentally Determined Cytological Location
Cytogenetic map Notes References 15D6-15D6     (McKim, 1995.9.5)
Experimentally Determined Recombination Data
Location	1-57 (Gatti, 1979) 1-56.2 (Hawley, 1992)
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\mei-218 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	gene_with_dicistronic_mRNA ; SO:0000722
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) mei-218-RB FBtr0100639  NM_167557   4130   1186 mei-218-RC FBtr0100640  NM_001031897   5005   1186 mei-218-RD FBtr0299823  NM_001144743   6125   1186 mei-218-RE FBtr0303847  NM_001201728   4420   1186
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein mei-218-PB   FBpp0100099   133.6   1186   8.28     NP_728052   AAN09433 mei-218-PC   FBpp0100100   133.6   1186   8.28     NP_001027068   AAF48699 mei-218-PD   FBpp0289101   133.6   1186   8.28     NP_001138215   ACL82945 mei-218-PE   FBpp0292855   133.6   1186   8.28     NP_001188657   ADV37739
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AE014298 AAF48699   AE014298 AAN09433   AE014298 ACL82945   AE014298 ADV37739   AI944958   AY122070 AAM52582   BF499521   BF500305   BF506299   BT023750   BT088962   BX051928   CO187136   CO191229   CO196499   CO269635   CO288292   CO310815   CO313444   CO315710   CO342311   EC066414   EC081548   EC082626   EC087584   EC231758   EC237200   EC240877   EC253561   EC257226   GH898739   U35631 AAB61476   Z32179
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q0KHR4 Q24137 Q8MR81
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage 1 -- 3   organism   (Fisher et al., 2012) Comment:maternally deposited
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
cytoplasm inferred from direct assay (Manheim et al., 2002)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: adult testis. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    18.55 Larval Midgut    6.1 Larval Hindgut    5.4 Larval Malpighian Tubules    2.6 Larval Fat Body    53.3 Larval Salivary Gland    3.2 Larval Trachea    5.4 Larval Carcass    5.6 Adult Head    3.7 Adult Eye    1.625 Adult Brain    5 Adult Thoracic-Abdominal Ganglion    7.2 Adult Crop    13.4 Adult Midgut    11 Adult Hindgut    7.8 Adult Malpighian Tubules    3.6 Adult Fat Body    6.2 Adult Salivary Gland    4.6 Adult Heart    4.25 Adult VirginFemale Spermatheca    1.7 Adult InseminatedFemale Spermatheca    4.4 Adult Ovary    64 Adult Testis    301 Adult Male Accessory Gland    10.4 Adult Carcass    12.1 Expression Level Scale  None   Low   Moderate  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    18.55 Larval Midgut    6.1 Larval Hindgut    5.4 Larval Malpighian Tubules    2.6 Larval Fat Body    53.3 Larval Salivary Gland    3.2 Larval Trachea    5.4 Larval Carcass    5.6 Adult Head    3.7 Adult Eye    1.625 Adult Brain    5 Adult Thoracic-Abdominal Ganglion    7.2 Adult Crop    13.4 Adult Midgut    11 Adult Hindgut    7.8 Adult Malpighian Tubules    3.6 Adult Fat Body    6.2 Adult Salivary Gland    4.6 Adult Heart    4.25 Adult VirginFemale Spermatheca    1.7 Adult InseminatedFemale Spermatheca    4.4 Adult Ovary    64 Adult Testis    301 Adult Male Accessory Gland    10.4 Adult Carcass    12.1 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    18.55 Larval Midgut    6.1 Larval Hindgut    5.4 Larval Malpighian Tubules    2.6 Larval Fat Body    53.3 Larval Salivary Gland    3.2 Larval Trachea    5.4 Larval Carcass    5.6 Adult Head    3.7 Adult Eye    1.625 Adult Brain    5 Adult Thoracic-Abdominal Ganglion    7.2 Adult Crop    13.4 Adult Midgut    11 Adult Hindgut    7.8 Adult Malpighian Tubules    3.6 Adult Fat Body    6.2 Adult Salivary Gland    4.6 Adult Heart    4.25 Adult VirginFemale Spermatheca    1.7 Adult InseminatedFemale Spermatheca    4.4 Adult Ovary    64 Adult Testis    301 Adult Male Accessory Gland    10.4 Adult Carcass    12.1 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    18.55 Larval Midgut    6.1 Larval Hindgut    5.4 Larval Malpighian Tubules    2.6 Larval Fat Body    53.3 Larval Salivary Gland    3.2 Larval Trachea    5.4 Larval Carcass    5.6 Adult Head    3.7 Adult Eye    1.625 Adult Brain    5 Adult Thoracic-Abdominal Ganglion    7.2 Adult Crop    13.4 Adult Midgut    11 Adult Hindgut    7.8 Adult Malpighian Tubules    3.6 Adult Fat Body    6.2 Adult Salivary Gland    4.6 Adult Heart    4.25 Adult VirginFemale Spermatheca    1.7 Adult InseminatedFemale Spermatheca    4.4 Adult Ovary    64 Adult Testis    301 Adult Male Accessory Gland    10.4 Adult Carcass    12.1 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    18.55 Larval Midgut    6.1 Larval Hindgut    5.4 Larval Malpighian Tubules    2.6 Larval Fat Body    53.3 Larval Salivary Gland    3.2 Larval Trachea    5.4 Larval Carcass    5.6 Adult Head    3.7 Adult Eye    1.625 Adult Brain    5 Adult Thoracic-Abdominal Ganglion    7.2 Adult Crop    13.4 Adult Midgut    11 Adult Hindgut    7.8 Adult Malpighian Tubules    3.6 Adult Fat Body    6.2 Adult Salivary Gland    4.6 Adult Heart    4.25 Adult VirginFemale Spermatheca    1.7 Adult InseminatedFemale Spermatheca    4.4 Adult Ovary    64 Adult Testis    301 Adult Male Accessory Gland    10.4 Adult Carcass    12.1 Expression Level Scale  None   Low   Moderate   High  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    18.55 Larval Midgut    6.1 Larval Hindgut    5.4 Larval Malpighian Tubules    2.6 Larval Fat Body    53.3 Larval Salivary Gland    3.2 Larval Trachea    5.4 Larval Carcass    5.6 Adult Head    3.7 Adult Eye    1.625 Adult Brain    5 Adult Thoracic-Abdominal Ganglion    7.2 Adult Crop    13.4 Adult Midgut    11 Adult Hindgut    7.8 Adult Malpighian Tubules    3.6 Adult Fat Body    6.2 Adult Salivary Gland    4.6 Adult Heart    4.25 Adult VirginFemale Spermatheca    1.7 Adult InseminatedFemale Spermatheca    4.4 Adult Ovary    64 Adult Testis    301 Adult Male Accessory Gland    10.4 Adult Carcass    12.1 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    18.55 Larval Midgut    6.1 Larval Hindgut    5.4 Larval Malpighian Tubules    2.6 Larval Fat Body    53.3 Larval Salivary Gland    3.2 Larval Trachea    5.4 Larval Carcass    5.6 Adult Head    3.7 Adult Eye    1.625 Adult Brain    5 Adult Thoracic-Abdominal Ganglion    7.2 Adult Crop    13.4 Adult Midgut    11 Adult Hindgut    7.8 Adult Malpighian Tubules    3.6 Adult Fat Body    6.2 Adult Salivary Gland    4.6 Adult Heart    4.25 Adult VirginFemale Spermatheca    1.7 Adult InseminatedFemale Spermatheca    4.4 Adult Ovary    64 Adult Testis    301 Adult Male Accessory Gland    10.4 Adult Carcass    12.1 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    18.55 Larval Midgut    6.1 Larval Hindgut    5.4 Larval Malpighian Tubules    2.6 Larval Fat Body    53.3 Larval Salivary Gland    3.2 Larval Trachea    5.4 Larval Carcass    5.6 Adult Head    3.7 Adult Eye    1.625 Adult Brain    5 Adult Thoracic-Abdominal Ganglion    7.2 Adult Crop    13.4 Adult Midgut    11 Adult Hindgut    7.8 Adult Malpighian Tubules    3.6 Adult Fat Body    6.2 Adult Salivary Gland    4.6 Adult Heart    4.25 Adult VirginFemale Spermatheca    1.7 Adult InseminatedFemale Spermatheca    4.4 Adult Ovary    64 Adult Testis    301 Adult Male Accessory Gland    10.4 Adult Carcass    12.1 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    3.7   NA  Eye    1.625   NA  Brain    5   18.55  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    7.2   NA  Crop    13.4   6.1  Midgut    no informative data   5.4  Hindgut    7.8   2.6  Malpighian Tubules    3.6   53.3  Fat Body    6.2   3.2  Salivary Gland    4.6   NA  Heart    4.25   5.4  Trachea    NA   NA  VirginFemale Spermatheca    1.7   NA  InseminatedFemale Spermatheca    4.4   NA  Ovary    64   NA  Testis    301   NA  Male Accessory Gland    no informative data   5.6  Carcass    no informative data FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    41 central nervous system, larvae L3    5 central nervous system, pupae P8    1 head, virgin 1-day female    0 head, virgin 4-day female    1 head, virgin 20-day female    0 head, mated 1-day female    0 head, mated 4-day female    0 head, mated 20-day female    1 head, mated 1-day male    1 head, mated 4-day male    1 head, mated 20-day male    1 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    2 digestive system, larvae L3 wandering    1 digestive system, 1-day adult    1 digestive system, 4-day adult    1 digestive system, 20-day adult    1 fat body, larvae L3 wandering    1 fat body, white prepupae    7 fat body, pupae P8    11 carcass, larvae L3 wandering    3 carcass, 1-day adult    1 carcass, 4-day adult    2 carcass, 20-day adult    2 ovary, virgin 4-day female    18 ovary, mated 4-day female    15 testis, mated 4-day male    33 accessory gland, mated 4-day male    7 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (41) central nervous system, larvae L3    5 central nervous system, pupae P8    1 head, virgin 1-day female    0 head, virgin 4-day female    1 head, virgin 20-day female    0 head, mated 1-day female    0 head, mated 4-day female    0 head, mated 20-day female    1 head, mated 1-day male    1 head, mated 4-day male    1 head, mated 20-day male    1 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    2 digestive system, larvae L3 wandering    1 digestive system, 1-day adult    1 digestive system, 4-day adult    1 digestive system, 20-day adult    1 fat body, larvae L3 wandering    1 fat body, white prepupae    7 fat body, pupae P8    11 carcass, larvae L3 wandering    3 carcass, 1-day adult    1 carcass, 4-day adult    2 carcass, 20-day adult    2 ovary, virgin 4-day female    18 ovary, mated 4-day female    15 testis, mated 4-day male  (33) accessory gland, mated 4-day male    7 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    41 central nervous system, larvae L3    5 central nervous system, pupae P8    1 head, virgin 1-day female    0 head, virgin 4-day female    1 head, virgin 20-day female    0 head, mated 1-day female    0 head, mated 4-day female    0 head, mated 20-day female    1 head, mated 1-day male    1 head, mated 4-day male    1 head, mated 20-day male    1 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    2 digestive system, larvae L3 wandering    1 digestive system, 1-day adult    1 digestive system, 4-day adult    1 digestive system, 20-day adult    1 fat body, larvae L3 wandering    1 fat body, white prepupae    7 fat body, pupae P8    11 carcass, larvae L3 wandering    3 carcass, 1-day adult    1 carcass, 4-day adult    2 carcass, 20-day adult    2 ovary, virgin 4-day female    18 ovary, mated 4-day female    15 testis, mated 4-day male    33 accessory gland, mated 4-day male    7 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    41 central nervous system, larvae L3    5 central nervous system, pupae P8    1 head, virgin 1-day female    0 head, virgin 4-day female    1 head, virgin 20-day female    0 head, mated 1-day female    0 head, mated 4-day female    0 head, mated 20-day female    1 head, mated 1-day male    1 head, mated 4-day male    1 head, mated 20-day male    1 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    2 digestive system, larvae L3 wandering    1 digestive system, 1-day adult    1 digestive system, 4-day adult    1 digestive system, 20-day adult    1 fat body, larvae L3 wandering    1 fat body, white prepupae    7 fat body, pupae P8    11 carcass, larvae L3 wandering    3 carcass, 1-day adult    1 carcass, 4-day adult    2 carcass, 20-day adult    2 ovary, virgin 4-day female    18 ovary, mated 4-day female    15 testis, mated 4-day male    33 accessory gland, mated 4-day male    7 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    41 central nervous system, larvae L3    5 central nervous system, pupae P8    1 head, virgin 1-day female    0 head, virgin 4-day female    1 head, virgin 20-day female    0 head, mated 1-day female    0 head, mated 4-day female    0 head, mated 20-day female    1 head, mated 1-day male    1 head, mated 4-day male    1 head, mated 20-day male    1 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    2 digestive system, larvae L3 wandering    1 digestive system, 1-day adult    1 digestive system, 4-day adult    1 digestive system, 20-day adult    1 fat body, larvae L3 wandering    1 fat body, white prepupae    7 fat body, pupae P8    11 carcass, larvae L3 wandering    3 carcass, 1-day adult    1 carcass, 4-day adult    2 carcass, 20-day adult    2 ovary, virgin 4-day female    18 ovary, mated 4-day female    15 testis, mated 4-day male    33 accessory gland, mated 4-day male    7 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (41) central nervous system, larvae L3    5 central nervous system, pupae P8    1 head, virgin 1-day female    0 head, virgin 4-day female    1 head, virgin 20-day female    0 head, mated 1-day female    0 head, mated 4-day female    0 head, mated 20-day female    1 head, mated 1-day male    1 head, mated 4-day male    1 head, mated 20-day male    1 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    2 digestive system, larvae L3 wandering    1 digestive system, 1-day adult    1 digestive system, 4-day adult    1 digestive system, 20-day adult    1 fat body, larvae L3 wandering    1 fat body, white prepupae    7 fat body, pupae P8    11 carcass, larvae L3 wandering    3 carcass, 1-day adult    1 carcass, 4-day adult    2 carcass, 20-day adult    2 ovary, virgin 4-day female    18 ovary, mated 4-day female    15 testis, mated 4-day male  (33) accessory gland, mated 4-day male    7 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    41 central nervous system, larvae L3    5 central nervous system, pupae P8    1 head, virgin 1-day female    0 head, virgin 4-day female    1 head, virgin 20-day female    0 head, mated 1-day female    0 head, mated 4-day female    0 head, mated 20-day female    1 head, mated 1-day male    1 head, mated 4-day male    1 head, mated 20-day male    1 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    2 digestive system, larvae L3 wandering    1 digestive system, 1-day adult    1 digestive system, 4-day adult    1 digestive system, 20-day adult    1 fat body, larvae L3 wandering    1 fat body, white prepupae    7 fat body, pupae P8    11 carcass, larvae L3 wandering    3 carcass, 1-day adult    1 carcass, 4-day adult    2 carcass, 20-day adult    2 ovary, virgin 4-day female    18 ovary, mated 4-day female    15 testis, mated 4-day male    33 accessory gland, mated 4-day male    7 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    41 central nervous system, larvae L3    5 central nervous system, pupae P8    1 head, virgin 1-day female    0 head, virgin 4-day female    1 head, virgin 20-day female    0 head, mated 1-day female    0 head, mated 4-day female    0 head, mated 20-day female    1 head, mated 1-day male    1 head, mated 4-day male    1 head, mated 20-day male    1 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    2 digestive system, larvae L3 wandering    1 digestive system, 1-day adult    1 digestive system, 4-day adult    1 digestive system, 20-day adult    1 fat body, larvae L3 wandering    1 fat body, white prepupae    7 fat body, pupae P8    11 carcass, larvae L3 wandering    3 carcass, 1-day adult    1 carcass, 4-day adult    2 carcass, 20-day adult    2 ovary, virgin 4-day female    18 ovary, mated 4-day female    15 testis, mated 4-day male    33 accessory gland, mated 4-day male    7 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of very low expression. Peak expression observed in adult male stages. This gene is annotated by FlyBase as a dicistronic gene, meaning that some or all of its transcripts encode two or more polypeptide-coding open reading frames (ORFs) , with each ORF assigned to a different gene. The distribution of RNA-Seq coverage data amongst the different encoded genes cannot be determined. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    12 embryo 02-04hr    6 embryo 04-06hr    8 embryo 06-08hr    8 embryo 08-10hr    6 embryo 10-12hr    3 embryo 12-14hr    2 embryo 14-16hr    1 embryo 16-18hr    1 embryo 18-20hr    1 embryo 20-22hr    1 embryo 22-24hr    1 larva L1    1 larva L2    1 larva L3 12hr old    1 larva L3 puffstage 1-2    2 larva L3 puffstage 3-6    5 larva L3 puffstage 7-9    6 white prepupae new    6 white prepupae 12hr    9 white prepupae 24hr    12 pupae 2d postWPP    12 pupae 3d postWPP    10 pupae 4d postWPP    6 adult male 01day    12 adult male 05day    20 adult male 30day    15 adult female 01day    3 adult female 05day    9 adult female 30day    9 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    12 embryo 02-04hr    6 embryo 04-06hr    8 embryo 06-08hr    8 embryo 08-10hr    6 embryo 10-12hr    3 embryo 12-14hr    2 embryo 14-16hr    1 embryo 16-18hr    1 embryo 18-20hr    1 embryo 20-22hr    1 embryo 22-24hr    1 larva L1    1 larva L2    1 larva L3 12hr old    1 larva L3 puffstage 1-2    2 larva L3 puffstage 3-6    5 larva L3 puffstage 7-9    6 white prepupae new    6 white prepupae 12hr    9 white prepupae 24hr    12 pupae 2d postWPP    12 pupae 3d postWPP    10 pupae 4d postWPP    6 adult male 01day    12 adult male 05day    20 adult male 30day    15 adult female 01day    3 adult female 05day    9 adult female 30day    9 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    12 embryo 02-04hr    6 embryo 04-06hr    8 embryo 06-08hr    8 embryo 08-10hr    6 embryo 10-12hr    3 embryo 12-14hr    2 embryo 14-16hr    1 embryo 16-18hr    1 embryo 18-20hr    1 embryo 20-22hr    1 embryo 22-24hr    1 larva L1    1 larva L2    1 larva L3 12hr old    1 larva L3 puffstage 1-2    2 larva L3 puffstage 3-6    5 larva L3 puffstage 7-9    6 white prepupae new    6 white prepupae 12hr    9 white prepupae 24hr    12 pupae 2d postWPP    12 pupae 3d postWPP    10 pupae 4d postWPP    6 adult male 01day    12 adult male 05day    20 adult male 30day    15 adult female 01day    3 adult female 05day    9 adult female 30day    9 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    12 embryo 02-04hr    6 embryo 04-06hr    8 embryo 06-08hr    8 embryo 08-10hr    6 embryo 10-12hr    3 embryo 12-14hr    2 embryo 14-16hr    1 embryo 16-18hr    1 embryo 18-20hr    1 embryo 20-22hr    1 embryo 22-24hr    1 larva L1    1 larva L2    1 larva L3 12hr old    1 larva L3 puffstage 1-2    2 larva L3 puffstage 3-6    5 larva L3 puffstage 7-9    6 white prepupae new    6 white prepupae 12hr    9 white prepupae 24hr    12 pupae 2d postWPP    12 pupae 3d postWPP    10 pupae 4d postWPP    6 adult male 01day    12 adult male 05day    20 adult male 30day    15 adult female 01day    3 adult female 05day    9 adult female 30day    9 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    12 embryo 02-04hr    6 embryo 04-06hr    8 embryo 06-08hr    8 embryo 08-10hr    6 embryo 10-12hr    3 embryo 12-14hr    2 embryo 14-16hr    1 embryo 16-18hr    1 embryo 18-20hr    1 embryo 20-22hr    1 embryo 22-24hr    1 larva L1    1 larva L2    1 larva L3 12hr old    1 larva L3 puffstage 1-2    2 larva L3 puffstage 3-6    5 larva L3 puffstage 7-9    6 white prepupae new    6 white prepupae 12hr    9 white prepupae 24hr    12 pupae 2d postWPP    12 pupae 3d postWPP    10 pupae 4d postWPP    6 adult male 01day    12 adult male 05day    20 adult male 30day    15 adult female 01day    3 adult female 05day    9 adult female 30day    9 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    12 embryo 02-04hr    6 embryo 04-06hr    8 embryo 06-08hr    8 embryo 08-10hr    6 embryo 10-12hr    3 embryo 12-14hr    2 embryo 14-16hr    1 embryo 16-18hr    1 embryo 18-20hr    1 embryo 20-22hr    1 embryo 22-24hr    1 larva L1    1 larva L2    1 larva L3 12hr old    1 larva L3 puffstage 1-2    2 larva L3 puffstage 3-6    5 larva L3 puffstage 7-9    6 white prepupae new    6 white prepupae 12hr    9 white prepupae 24hr    12 pupae 2d postWPP    12 pupae 3d postWPP    10 pupae 4d postWPP    6 adult male 01day    12 adult male 05day    20 adult male 30day    15 adult female 01day    3 adult female 05day    9 adult female 30day    9 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    12 embryo 02-04hr    6 embryo 04-06hr    8 embryo 06-08hr    8 embryo 08-10hr    6 embryo 10-12hr    3 embryo 12-14hr    2 embryo 14-16hr    1 embryo 16-18hr    1 embryo 18-20hr    1 embryo 20-22hr    1 embryo 22-24hr    1 larva L1    1 larva L2    1 larva L3 12hr old    1 larva L3 puffstage 1-2    2 larva L3 puffstage 3-6    5 larva L3 puffstage 7-9    6 white prepupae new    6 white prepupae 12hr    9 white prepupae 24hr    12 pupae 2d postWPP    12 pupae 3d postWPP    10 pupae 4d postWPP    6 adult male 01day    12 adult male 05day    20 adult male 30day    15 adult female 01day    3 adult female 05day    9 adult female 30day    9 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    12 embryo 02-04hr    6 embryo 04-06hr    8 embryo 06-08hr    8 embryo 08-10hr    6 embryo 10-12hr    3 embryo 12-14hr    2 embryo 14-16hr    1 embryo 16-18hr    1 embryo 18-20hr    1 embryo 20-22hr    1 embryo 22-24hr    1 larva L1    1 larva L2    1 larva L3 12hr old    1 larva L3 puffstage 1-2    2 larva L3 puffstage 3-6    5 larva L3 puffstage 7-9    6 white prepupae new    6 white prepupae 12hr    9 white prepupae 24hr    12 pupae 2d postWPP    12 pupae 3d postWPP    10 pupae 4d postWPP    6 adult male 01day    12 adult male 05day    20 adult male 30day    15 adult female 01day    3 adult female 05day    9 adult female 30day    9 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    10 Schneider line 2 Sg4    5 embryonic 1182-4H    7 embryonic GM2    11 embryonic Kc167    10 embryonic S1    13 embryonic S3    9 leg disc CME L1    5 wing disc CME-W2    11 wing disc ML-DmD8    8 wing disc ML-DmD9    9 wing disc ML-DmD16-c3    8 wing disc ML-DmD21    3 wing disc ML-DmD32    7 haltere disc ML-DmD17-c3    13 eye-antennal disc ML-DmD11    8 antennal disc ML-DmD20-c5    5 mixed discs ML-DmD4-c1    5 CNS ML-DmBG1-c1    12 CNS ML-DmBG2-c2    10 tumorous blood cells mbn2    14 ovary fGS/OSS    11 ovary OSC    17 ovary OSS    5 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    10 Schneider line 2 Sg4    5 embryonic 1182-4H    7 embryonic GM2    11 embryonic Kc167    10 embryonic S1    13 embryonic S3    9 leg disc CME L1    5 wing disc CME-W2    11 wing disc ML-DmD8    8 wing disc ML-DmD9    9 wing disc ML-DmD16-c3    8 wing disc ML-DmD21    3 wing disc ML-DmD32    7 haltere disc ML-DmD17-c3    13 eye-antennal disc ML-DmD11    8 antennal disc ML-DmD20-c5    5 mixed discs ML-DmD4-c1    5 CNS ML-DmBG1-c1    12 CNS ML-DmBG2-c2    10 tumorous blood cells mbn2    14 ovary fGS/OSS    11 ovary OSC    17 ovary OSS    5 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    10 Schneider line 2 Sg4    5 embryonic 1182-4H    7 embryonic GM2    11 embryonic Kc167    10 embryonic S1    13 embryonic S3    9 leg disc CME L1    5 wing disc CME-W2    11 wing disc ML-DmD8    8 wing disc ML-DmD9    9 wing disc ML-DmD16-c3    8 wing disc ML-DmD21    3 wing disc ML-DmD32    7 haltere disc ML-DmD17-c3    13 eye-antennal disc ML-DmD11    8 antennal disc ML-DmD20-c5    5 mixed discs ML-DmD4-c1    5 CNS ML-DmBG1-c1    12 CNS ML-DmBG2-c2    10 tumorous blood cells mbn2    14 ovary fGS/OSS    11 ovary OSC    17 ovary OSS    5 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    10 Schneider line 2 Sg4    5 embryonic 1182-4H    7 embryonic GM2    11 embryonic Kc167    10 embryonic S1    13 embryonic S3    9 leg disc CME L1    5 wing disc CME-W2    11 wing disc ML-DmD8    8 wing disc ML-DmD9    9 wing disc ML-DmD16-c3    8 wing disc ML-DmD21    3 wing disc ML-DmD32    7 haltere disc ML-DmD17-c3    13 eye-antennal disc ML-DmD11    8 antennal disc ML-DmD20-c5    5 mixed discs ML-DmD4-c1    5 CNS ML-DmBG1-c1    12 CNS ML-DmBG2-c2    10 tumorous blood cells mbn2    14 ovary fGS/OSS    11 ovary OSC    17 ovary OSS    5 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    10 Schneider line 2 Sg4    5 embryonic 1182-4H    7 embryonic GM2    11 embryonic Kc167    10 embryonic S1    13 embryonic S3    9 leg disc CME L1    5 wing disc CME-W2    11 wing disc ML-DmD8    8 wing disc ML-DmD9    9 wing disc ML-DmD16-c3    8 wing disc ML-DmD21    3 wing disc ML-DmD32    7 haltere disc ML-DmD17-c3    13 eye-antennal disc ML-DmD11    8 antennal disc ML-DmD20-c5    5 mixed discs ML-DmD4-c1    5 CNS ML-DmBG1-c1    12 CNS ML-DmBG2-c2    10 tumorous blood cells mbn2    14 ovary fGS/OSS    11 ovary OSC    17 ovary OSS    5 Expression Level Scale  Very low   Low   Moderate  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    10 Schneider line 2 Sg4    5 embryonic 1182-4H    7 embryonic GM2    11 embryonic Kc167    10 embryonic S1    13 embryonic S3    9 leg disc CME L1    5 wing disc CME-W2    11 wing disc ML-DmD8    8 wing disc ML-DmD9    9 wing disc ML-DmD16-c3    8 wing disc ML-DmD21    3 wing disc ML-DmD32    7 haltere disc ML-DmD17-c3    13 eye-antennal disc ML-DmD11    8 antennal disc ML-DmD20-c5    5 mixed discs ML-DmD4-c1    5 CNS ML-DmBG1-c1    12 CNS ML-DmBG2-c2    10 tumorous blood cells mbn2    14 ovary fGS/OSS    11 ovary OSC    17 ovary OSS    5 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    10 Schneider line 2 Sg4    5 embryonic 1182-4H    7 embryonic GM2    11 embryonic Kc167    10 embryonic S1    13 embryonic S3    9 leg disc CME L1    5 wing disc CME-W2    11 wing disc ML-DmD8    8 wing disc ML-DmD9    9 wing disc ML-DmD16-c3    8 wing disc ML-DmD21    3 wing disc ML-DmD32    7 haltere disc ML-DmD17-c3    13 eye-antennal disc ML-DmD11    8 antennal disc ML-DmD20-c5    5 mixed discs ML-DmD4-c1    5 CNS ML-DmBG1-c1    12 CNS ML-DmBG2-c2    10 tumorous blood cells mbn2    14 ovary fGS/OSS    11 ovary OSC    17 ovary OSS    5 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    10 Schneider line 2 Sg4    5 embryonic 1182-4H    7 embryonic GM2    11 embryonic Kc167    10 embryonic S1    13 embryonic S3    9 leg disc CME L1    5 wing disc CME-W2    11 wing disc ML-DmD8    8 wing disc ML-DmD9    9 wing disc ML-DmD16-c3    8 wing disc ML-DmD21    3 wing disc ML-DmD32    7 haltere disc ML-DmD17-c3    13 eye-antennal disc ML-DmD11    8 antennal disc ML-DmD20-c5    5 mixed discs ML-DmD4-c1    5 CNS ML-DmBG1-c1    12 CNS ML-DmBG2-c2    10 tumorous blood cells mbn2    14 ovary fGS/OSS    11 ovary OSC    17 ovary OSS    5 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    3 cold shock, 4-day adult    3 heat shock, 4-day adult    5 Cadmium 50 mM 6 hrs, larvae L3    2 Cadmium 50 mM 12 hrs, larvae L3    2 Cadmium 50 mM 48 hrs, 4-day adult    6 Cadmium 100 mM 48 hrs, 4-day adult    13 Copper 0.5 mM 12 hrs, larvae L3    2 Copper 15 mM 48 hrs, 4-day adult    11 Zinc 5 mM 12 hrs, larvae L3    2 Zinc 4.5 mM 48 hrs, 4-day adult    9 Ethanol 2.5% 3 hrs, larvae L3    12 Ethanol 5% 3 hrs, larvae L3    2 Ethanol 10% 3 hrs, larvae L3    1 Caffeine 1.5 mg/ml 4 hrs, larvae L3    3 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    11 Caffeine 25 mg/ml 48 hrs, 4-day adult    5 Paraquat 5 mM 48 hrs, 4-day adult    11 Paraquat 10 mM 48 hrs, 4-day adult    11 Rotenone 2 μg 12 hrs, larvae L3    2 Rotenone 8 μg 12 hrs, larvae L3    2 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    3 cold shock, 4-day adult    3 heat shock, 4-day adult    5 Cadmium 50 mM 6 hrs, larvae L3    2 Cadmium 50 mM 12 hrs, larvae L3    2 Cadmium 50 mM 48 hrs, 4-day adult    6 Cadmium 100 mM 48 hrs, 4-day adult    13 Copper 0.5 mM 12 hrs, larvae L3    2 Copper 15 mM 48 hrs, 4-day adult    11 Zinc 5 mM 12 hrs, larvae L3    2 Zinc 4.5 mM 48 hrs, 4-day adult    9 Ethanol 2.5% 3 hrs, larvae L3    12 Ethanol 5% 3 hrs, larvae L3    2 Ethanol 10% 3 hrs, larvae L3    1 Caffeine 1.5 mg/ml 4 hrs, larvae L3    3 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    11 Caffeine 25 mg/ml 48 hrs, 4-day adult    5 Paraquat 5 mM 48 hrs, 4-day adult    11 Paraquat 10 mM 48 hrs, 4-day adult    11 Rotenone 2 μg 12 hrs, larvae L3    2 Rotenone 8 μg 12 hrs, larvae L3    2 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    3 cold shock, 4-day adult    3 heat shock, 4-day adult    5 Cadmium 50 mM 6 hrs, larvae L3    2 Cadmium 50 mM 12 hrs, larvae L3    2 Cadmium 50 mM 48 hrs, 4-day adult    6 Cadmium 100 mM 48 hrs, 4-day adult    13 Copper 0.5 mM 12 hrs, larvae L3    2 Copper 15 mM 48 hrs, 4-day adult    11 Zinc 5 mM 12 hrs, larvae L3    2 Zinc 4.5 mM 48 hrs, 4-day adult    9 Ethanol 2.5% 3 hrs, larvae L3    12 Ethanol 5% 3 hrs, larvae L3    2 Ethanol 10% 3 hrs, larvae L3    1 Caffeine 1.5 mg/ml 4 hrs, larvae L3    3 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    11 Caffeine 25 mg/ml 48 hrs, 4-day adult    5 Paraquat 5 mM 48 hrs, 4-day adult    11 Paraquat 10 mM 48 hrs, 4-day adult    11 Rotenone 2 μg 12 hrs, larvae L3    2 Rotenone 8 μg 12 hrs, larvae L3    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    3 cold shock, 4-day adult    3 heat shock, 4-day adult    5 Cadmium 50 mM 6 hrs, larvae L3    2 Cadmium 50 mM 12 hrs, larvae L3    2 Cadmium 50 mM 48 hrs, 4-day adult    6 Cadmium 100 mM 48 hrs, 4-day adult    13 Copper 0.5 mM 12 hrs, larvae L3    2 Copper 15 mM 48 hrs, 4-day adult    11 Zinc 5 mM 12 hrs, larvae L3    2 Zinc 4.5 mM 48 hrs, 4-day adult    9 Ethanol 2.5% 3 hrs, larvae L3    12 Ethanol 5% 3 hrs, larvae L3    2 Ethanol 10% 3 hrs, larvae L3    1 Caffeine 1.5 mg/ml 4 hrs, larvae L3    3 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    11 Caffeine 25 mg/ml 48 hrs, 4-day adult    5 Paraquat 5 mM 48 hrs, 4-day adult    11 Paraquat 10 mM 48 hrs, 4-day adult    11 Rotenone 2 μg 12 hrs, larvae L3    2 Rotenone 8 μg 12 hrs, larvae L3    2 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    3 cold shock, 4-day adult    3 heat shock, 4-day adult    5 Cadmium 50 mM 6 hrs, larvae L3    2 Cadmium 50 mM 12 hrs, larvae L3    2 Cadmium 50 mM 48 hrs, 4-day adult    6 Cadmium 100 mM 48 hrs, 4-day adult    13 Copper 0.5 mM 12 hrs, larvae L3    2 Copper 15 mM 48 hrs, 4-day adult    11 Zinc 5 mM 12 hrs, larvae L3    2 Zinc 4.5 mM 48 hrs, 4-day adult    9 Ethanol 2.5% 3 hrs, larvae L3    12 Ethanol 5% 3 hrs, larvae L3    2 Ethanol 10% 3 hrs, larvae L3    1 Caffeine 1.5 mg/ml 4 hrs, larvae L3    3 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    11 Caffeine 25 mg/ml 48 hrs, 4-day adult    5 Paraquat 5 mM 48 hrs, 4-day adult    11 Paraquat 10 mM 48 hrs, 4-day adult    11 Rotenone 2 μg 12 hrs, larvae L3    2 Rotenone 8 μg 12 hrs, larvae L3    2 Expression Level Scale  Very low   Low   Moderate  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    3 cold shock, 4-day adult    3 heat shock, 4-day adult    5 Cadmium 50 mM 6 hrs, larvae L3    2 Cadmium 50 mM 12 hrs, larvae L3    2 Cadmium 50 mM 48 hrs, 4-day adult    6 Cadmium 100 mM 48 hrs, 4-day adult    13 Copper 0.5 mM 12 hrs, larvae L3    2 Copper 15 mM 48 hrs, 4-day adult    11 Zinc 5 mM 12 hrs, larvae L3    2 Zinc 4.5 mM 48 hrs, 4-day adult    9 Ethanol 2.5% 3 hrs, larvae L3    12 Ethanol 5% 3 hrs, larvae L3    2 Ethanol 10% 3 hrs, larvae L3    1 Caffeine 1.5 mg/ml 4 hrs, larvae L3    3 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    11 Caffeine 25 mg/ml 48 hrs, 4-day adult    5 Paraquat 5 mM 48 hrs, 4-day adult    11 Paraquat 10 mM 48 hrs, 4-day adult    11 Rotenone 2 μg 12 hrs, larvae L3    2 Rotenone 8 μg 12 hrs, larvae L3    2 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    3 cold shock, 4-day adult    3 heat shock, 4-day adult    5 Cadmium 50 mM 6 hrs, larvae L3    2 Cadmium 50 mM 12 hrs, larvae L3    2 Cadmium 50 mM 48 hrs, 4-day adult    6 Cadmium 100 mM 48 hrs, 4-day adult    13 Copper 0.5 mM 12 hrs, larvae L3    2 Copper 15 mM 48 hrs, 4-day adult    11 Zinc 5 mM 12 hrs, larvae L3    2 Zinc 4.5 mM 48 hrs, 4-day adult    9 Ethanol 2.5% 3 hrs, larvae L3    12 Ethanol 5% 3 hrs, larvae L3    2 Ethanol 10% 3 hrs, larvae L3    1 Caffeine 1.5 mg/ml 4 hrs, larvae L3    3 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    11 Caffeine 25 mg/ml 48 hrs, 4-day adult    5 Paraquat 5 mM 48 hrs, 4-day adult    11 Paraquat 10 mM 48 hrs, 4-day adult    11 Rotenone 2 μg 12 hrs, larvae L3    2 Rotenone 8 μg 12 hrs, larvae L3    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    3 cold shock, 4-day adult    3 heat shock, 4-day adult    5 Cadmium 50 mM 6 hrs, larvae L3    2 Cadmium 50 mM 12 hrs, larvae L3    2 Cadmium 50 mM 48 hrs, 4-day adult    6 Cadmium 100 mM 48 hrs, 4-day adult    13 Copper 0.5 mM 12 hrs, larvae L3    2 Copper 15 mM 48 hrs, 4-day adult    11 Zinc 5 mM 12 hrs, larvae L3    2 Zinc 4.5 mM 48 hrs, 4-day adult    9 Ethanol 2.5% 3 hrs, larvae L3    12 Ethanol 5% 3 hrs, larvae L3    2 Ethanol 10% 3 hrs, larvae L3    1 Caffeine 1.5 mg/ml 4 hrs, larvae L3    3 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    11 Caffeine 25 mg/ml 48 hrs, 4-day adult    5 Paraquat 5 mM 48 hrs, 4-day adult    11 Paraquat 10 mM 48 hrs, 4-day adult    11 Rotenone 2 μg 12 hrs, larvae L3    2 Rotenone 8 μg 12 hrs, larvae L3    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_21
External Data & Images
Linkouts	BDGP expression data • AT14088 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0002709 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG33067-RC
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele viable mei-2184 mei-2185 mei-2186 mei-2187 mei-2188 mei-218f04441 Sterility Allele female fertile mei-2184 mei-2185 mei-2186 mei-2187 mei-2188 female semi-sterile mei-2181 fertile mei-218f04441 male fertile mei-2184 mei-2185 mei-2186 mei-2187 mei-2188 Other Phenotypes Allele DNA repair defective mei-218unspecified meiotic cell cycle defective mei-2181 mei-2186-7 mei-218hfnd mei-218unspecified meiotic cell cycle defective | female mei-2181 mei-2186 wild-type mei-218+t15 mei-218Hsp83.PM mei-218Hsp83.SV40.T:Zzzz\FLAG mei-218Hsp83.T:Zzzz\FLAG Phenotype manifest in Allele cell cycle mei-2186-7 meiosis & nuclear chromosome | female mei-2186 oocyte mei-2186-7
Classical Alleles ( 17 )
For All Classical Alleles Show
Allele of mei-218 Class Mutagen Stocks Known lesion mei-2181 2 -- mei-2186-7 2 -- mei-218f04441 piggyBac transposase 1 Yes mei-218HP10279 1 -- mei-2184 hypomorphic allele - genetic evidence ethyl methanesulfonate 0 -- mei-2185 ethyl methanesulfonate 0 -- mei-2186 ethyl methanesulfonate 0 -- mei-2187 ethyl methanesulfonate 0 -- mei-2188 ethyl methanesulfonate 0 -- mei-218g1 ethyl methanesulfonate 0 -- mei-218g2 0 -- mei-218g4 ethyl methanesulfonate 0 -- mei-218g9 ethyl methanesulfonate 0 -- mei-218hfnd 0 -- mei-218j1 ethyl methanesulfonate 0 -- mei-218j2 ethyl methanesulfonate 0 -- mei-218unspecified 0 --
Alleles Carried on Transgenic Constructs ( 4 )
For All Alleles Carried on Transgenic Constructs Show
Allele of mei-218 Class Mutagen Stocks Known lesion mei-218+t15 in vitro construct - genomic fragment 0 Yes mei-218Hsp83.PM in vitro construct - regulatory fusion 0 Yes mei-218Hsp83.SV40.T:Zzzz\FLAG in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes mei-218Hsp83.T:Zzzz\FLAG in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(1)815-6 (McKim et al., 1996) Df(1)BK8 (McKim et al., 1996) Df(1)BK16 (McKim et al., 1996) Df(1)BK17 (McKim et al., 1996) Df(1)BK18 (McKim et al., 1996) Df(1)BK28 (McKim et al., 1996)
Duplicated in	Dp(1;3)f+71b (McKim et al., 1996) Dp(1;4)fK7 (McKim et al., 1996) Dp(1;4)fK27 (McKim et al., 1996) Dp(1;4)r+l (McKim et al., 1996) Dp(1;4)rK20 (McKim et al., 1996) Dp(1;Y)W73 (McKim et al., 1996)
Not disrupted in	Df(1)B (McKim et al., 1996) Df(1)BK10 (McKim et al., 1996)
Not duplicated in	Dp(1;4)fK4 (McKim et al., 1996) Dp(1;4)fK24 (McKim et al., 1996)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data heat-shock construct P{hs-mei-218.M} NA P{Hsp83-mei-218.FLAG} NA P{Hsp83-mei-218.FLAG-SV40} NA characterization construct P{HK3X218} NA P{HKF218} NA P{mei-218+15} NA
Insertions
	Type of insertions Name Expression data miscellaneous insertions PBac{WH}mei-217f04441 NA insertion of mobile activating element P{EPg}mei-217HP10279 NA
Gene Ontology: Function, Process & Cellular Component ( 3 unique terms )
Terms Based on Experimental Evidence ( 3 terms )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
female meiosis chromosome segregation inferred from mutant phenotype (Baker and Carpenter, 1972) reciprocal meiotic recombination inferred from mutant phenotype (Baker and Carpenter, 1972)
Cellular Component
CV term Evidence References
cytoplasm inferred from direct assay (Manheim et al., 2002)
Terms Based on Predictions or Assertions ( 1 term )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
reciprocal meiotic recombination traceable author statement (Manheim et al., 2002)
Cellular Component ( 0 terms)
Sequence Ontology: Class of Gene
	gene_with_dicistronic_mRNA (FlyBase Genome Annotators, 2002-2003) nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions mei-218 allele Gene References mei-2181 nod (Apionishev et al., 2001) spn-B (Liu et al., 2000) mei-2186 lwr (Apionishev et al., 2001)
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 534243 DroID - A comprehensive database of gene and protein interactions. • FBgn0002709 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 3772646
Orthologs
OrthoDB Orthologs (15) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG6STSQN Dipteran inclusive ortholog search EOG6XH07V Insect inclusive ortholog search EOG6N5TSP Arthropod inclusive ortholog search EOG6X69R1 Metazoa inclusive ortholog search No orthologs identified
Orthologs in Drosophila Species (EOG6STSQN)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\mei-218     Drosophila simulans   Dsim\mei-218     Drosophila sechellia   Dsec\GM13338     Drosophila erecta   Dere\GG18203     Drosophila yakuba   Dyak\mei-218     Drosophila ananassae   Dana\GF22380     Drosophila pseudoobscura pseudoobscura   Dpse\GA17258     Drosophila persimilis   Dper\GL20336 Y   Drosophila willistoni   Dwil\GK20079     Drosophila virilis   Dvir\mei-218     Drosophila mojavensis   Dmoj\GI15825     Drosophila grimshawi   Dgri\GH24636
Orthologs in non-Drosophila Dipterans (EOG6XH07V)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ007168
Orthologs in non-Dipteran Insects (EOG6N5TSP)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Bombyx mori Silkmoth  Bmor\BGIBMGA008428   Pediculus humanus Human body louse  Phum\PHUM401830
Orthologs in non-Insect Arthropods (None identified)
No non-Insect Arthropod orthologies identified
Orthologs in non-Arthropod Metazoa (None identified)
No non-Arthropod Metazoa orthologies identified
Human Orthologs (0)
Gene OMIM HGNC
AAA Orthologs (1) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila persimilis Dper\GL20336
Stocks & Reagents
Stocks Listed in FlyBase ( 6 )
Bloomington	18770 w1118 PBac{WH}mei-217f04441 mei-218f04441 21866 w1118 P{EPg}mei-217HP10279 mei-218HP10279 4879 y1 mei-2186-7/C(1)RM, y1 bb*/Dp(1;Y)y+; Sb1/TM6 4914 Dp(1;1)scV1, y1 mei-2181 car1, y+/C(1)DX, y1 f1
Kyoto	107926 y1 mei-2186-7/C(1)RM, y1 bb*/Dp(1;Y)y+; TM6/Sb1 100965 Dp(1;Y)BS, BS / C(1)DX, y1 w1 f1 / y1 mei-9b cv1 ct6 mei-2181
Genomic Clones ( 2 )
	BACR06G02 BACR15L12 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 25 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	AT14088 SD24912 SD27194
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	AT08740 AT15152
Other clones	100021 107280 159252 214411.38 214509.30 bs07d06 CK01.30B.D7 CK01.86B.G4 CK01.124A.F6 CK01.125A.D5 EC30487 EK005005 EK026616 EK068158 EK095413 EK222560 EK232946 EK262259 EP14448 RP003642669
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0002709 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 3772646
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of
Additional comments	Dicistronic annotation CG33067 split out into separate annotations for each open reading frame, CG33935 and CG8923, in release 4.2 of the genome annotation. CG33935 corresponds to mei-217 and CG8923 corresponds to mei-218. (FlyBase Genome Annotators, 2005) One or more of the processed transcripts for this gene contain(s) two non-overlapping open reading frames (ORFs). The non-overlapping ORFs are represented by mei-217 and mei-218 (FlyBase Genome Annotators, 2002-2003)
Other Comments
	mei-217 and mei-218 are most likely produced from a dicistronic mRNA. Overall orientation not stated: RpS5a+ mei-217+ mei-218+ mei-217+ mei-218+ (Liu et al., 2000) Complete absence of the mei-218 gene product reduces, but does not eliminate, meiotic crossing over. (McKim et al., 1996) nod protein persists on the meiotic chromosomes until the completion of meiosis. (Afshar et al., 1995) mei-218 mutants show a failure of metaphase arrest similar to that observed for the All-Compound genotype. (Jang et al., 1995) mei-218 gene product inhibits mutagenesis at early stages of oogenesis. (Okladnova and Georgiev, 1992)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_167557 NM_001031897 NM_001144743 NM_001201728 RefSeq (Proteins) • NP_728052 NP_001027068 NP_001138215 NP_001188657 DDBJ / EMBL / GenBank • AAB61476 AAF48699 AAF48699.1 AAM52582 AAN09433 AAO41687.1 AAO41688.1 ACL82945 ADV37739 AI944958 AY122070 BF499521 U35631 Z32179 Entrez Gene - A searchable database of RefSeq genes. • 3772646 UniProtKB/TrEMBL • Q0KHR4 Q8MR81 Q24137
Other Crossreferences
	BDGP expression data - Patterns of gene expression in Drosophila embryogenesis • AT14088
Linkouts
	BioGRID - A database of protein and genetic interactions • 534243 DroID - A comprehensive database of gene and protein interactions. • FBgn0002709 DRSC - Results from RNAi screens. • FBgn0002709 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0002709 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG33067-RC FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0002709 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 3772646 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 3772646 modMine - Data generated by the modENCODE project. • FBgn0002709
Synonyms & Secondary IDs ( 5 )
Reported As
Symbol Synonym	CG8923 (Oliver, 2001.8.16, ) CG33067 (Giot et al., 2003, ) mei-218 (Apionishev et al., 2001, Tanneti et al., 2008, Blanton et al., 2005, Baker and Carpenter, 1972, Jang et al., 2005, Joyce and McKim, 2009, Anderson et al., 2009, Joyce et al., 2009, Wu et al., 2008, Meyer et al., 2010, Reis et al., 2011)
Name Synonym	meiotic 218   transcript c (McKim et al., 1996)
Secondary FlyBase IDs
	FBgn0053067 FBpp0088760 FBpp0088761 FBpp0088762 FBtr0089819 FBtr0089820 FBtr0089821
References ( 72 )
Generate a list of	All references relating to this gene ( 72 )
List References by type	Research paper  ( 41 ) Supplementary material  ( 2 ) Review  ( 5 ) Personal communication to FlyBase  ( 5 ) Abstract  ( 10 ) FlyBase analysis  ( 4 ) DNA/RNA sequence record  ( 2 ) Website  ( 1 ) Letter  ( 1 ) Curated genome annotation  ( 1 )
Recent research papers ( 4 )
	Collins et al., 2012, G3 (Bethesda) 2(11): 1369--1377 A Germline Clone Screen on the X Chromosome Reveals Novel Meiotic Mutants in Drosophila melanogaster. [FBrf0219963] Joyce et al., 2012, Genetics 191(3): 739--746 Multiple barriers to nonhomologous DNA end joining during meiosis in Drosophila. [FBrf0218878] Kohl et al., 2012, Science 338(6112): 1363--1365 Evolution of an MCM complex in flies that promotes meiotic crossovers by blocking BLM helicase. [FBrf0220159] Reis et al., 2011, PLoS ONE 6(3): e17512 Drosophila Genes That Affect Meiosis Duration Are among the Meiosis Related Genes That Are More Often Found Duplicated. [FBrf0213266] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2011 Show reviews ...