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Gene Dmel\mei-S332

General Information
Symbol	Dmel\mei-S332	Species	D. melanogaster
Name	meiotic from via Salaria 332	Annotation symbol	CG5303
Feature type	protein_coding_gene	FlyBase ID	FBgn0002715
Gene Model Status	Current	Stock availability	8 publicly available
Also Known As	MeiS332, mei-S322
Genomic Location
Chromosome (arm)	2R	Recombination map	2-
Cytogenetic map	58B9-58B10	Sequence location	2R:18,009,606..18,012,071 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene meiotic from via Salaria 332 is referred to in FlyBase by the symbol Dmel\mei-S332 (CG5303, FBgn0002715). It is a protein_coding_gene from Drosophila melanogaster. Its molecular function is unknown. There is experimental evidence that it is involved in the biological process: female meiosis; male meiosis sister chromatid cohesion; male meiosis; sister chromatid cohesion. 35 alleles are reported. The phenotypes of these alleles are annotated with: mitosis; wing disc; imaginal disc. It has one annotated transcript and one annotated polypeptide. Protein features are: Shugoshin, C-terminal; Shugoshin, N-terminal. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of very low expression. Peak expression observed within 00-12 hour embryonic stages, during early pupal stages, in adult male stages. Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: larval central nervous system, adult ovary, adult testis. Comments on Affy2 ProbeSet: ProbeSet 1639029_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of mei-S332. Gene sequence location is 2R:18009606..18012071.
External Summaries
Phenotypic Description from the Red Book (Lindsley & Zimm 1992)
Gene/Allele symbols may differ from current usage	mei-S332 (R.S. Hawley) mei-S332 is a semidominant autosomal mutation that increases nondisjunction of all chromosomes to the same extent in both sexes. Although female recombination is normal, mei-S332 causes high frequencies of equational nondisjunction in both sexes as well as chromosome loss (Davis, 1971; Goldstein, 1980). In the male germline sister chromatid associations are generally normal during prophase I and metaphase I. However, by telophase I sister chromatids have frequently undergone precocious separation (Goldstein, 1980). The equational exceptions produced by mei-S332 males and females presumably result from precociously separated sister chromatids going to the same pole at anaphase II. Goldstein (1980) has also suggested that "in the case of mei-S332, chromosomes which lag in the second meiotic division are usually lost and most of the genetically observed loss in mei-S332 occurs in the second meiotic division." The hypothesis that lagging chromatids are often lost at anaphase II is consistent with Hardy's observation that mei-S332 has micronuclei present at the early spermatid stages (Hardy, 1975). Thus mei-S332 presumably defines a function required for sister chromatid cohesion. Sandler et al. (1974) have shown that ring chromosomes are frequently converted into dominant lethals in mei-S332 females, presumably resulting from an impaired ability to resolve sister ring chromosomes at anaphase II. Baker et al. (1978) have also shown that mitotic chromosome instability is elevated in the presence of mei-S332. They suggest that the function of the mei-S332+ locus is to delay the separation of sister chromatids at all divisions. Because the sole mei-S332 allele is viable, they have further suggested that either this allele is leaky or that there are overlapping or redundant functions that can compensate for this defect.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2011_10	Controlled Vocabulary Terms male meiosis sister chromatid cohesion condensed nuclear chromosome, centromeric region
FB2012_01	References Magwire et al., 2010, PLoS Genet. 6(7): e1001037 Sequence features BKN27238 HFA04704
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 58B9-58B10   Limits computationally determined from genome sequence between P{EP}CG6393EP2457 and P{PZ}ari-207768
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location	2- (Sandler et al., 1968)
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\mei-S332 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) mei-S332-RA FBtr0071761  NM_057286   1703   401
Additional Transcript Data & Comments
Reported size (kB)	1.8, 1.75, 1.6, 1.55 (northern blot) (Kerrebrock et al., 1995)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein mei-S332-PA   FBpp0071675   44.4   401   8.68     NP_476634   AAF46802
Additional Polypeptide Data & Comments
Reported size (kDa)	401 (aa); 44 (kD predicted) (Kerrebrock et al., 1995)
Comments	mei-S332 protein was shown to assemble onto chromosomes during prometaphase. In meiosis, mei-S332 protein exhibits nuclear localization at late meiotic prophase I. The carboxy-terminus was shown to be essential for centromere localization both in mitosis and meiosis. Alterations in the basic region impede but do not prevent chromosomal localization. The coiled-coil structure is not necessary for mei-S332 protein chromosomal localization. (Tang et al., 1998)
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Shugoshin, C-terminal (IPR011515) Shugoshin, N-terminal (IPR011516)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA202823   AA264132   AA440503   AA949357   AA978893   AE013599 AAF46802   AC003054   AI511936   AI516157   AI520577   AI944994   AW943164   AY058633 AAL13862   BH023723   BI163696   BI237238   BI362160   BI482631   CK131988   CO295353   CO304647   CO320508   EC065708   EC212983   EC216073   EV599938   GH751373   GH760450   GH770592   GH772112   GH772434   GH778398   GH784974   GH786707   GH788350   GH789572   GH791672   GH792388   GH794719   GH800478   GH801734   GH807401   GH809324   GH812602   GH813978   GH814856   GH820353   GH821648   GH826845   GH830162   GH831241   GH833101   GH834473   GH835086   GH835437   GH840729   GH842262   GH846334   GH852524   GH853391   GH854075   GH854375   GH861863   GH863688   GH863836   GH864489   GH867432   GH868906   GH871411   GH873746   GH876204   GH877221   GH878126   GH878485   GH879534   GH884451   GH884848   GH884930   GH886583   GH907828   GH909853   GH911057   GH928449   GH928900   GH929265   GH929582   GH929921   GH931854   U36583 AAA87038
UniProtKB/Swiss-Prot	Q24141
UniProtKB/TrEMBL
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
northern blot Stage Tissue/Position (including subcellular localization) Reference embryonic stage -- adult stage     (Kerrebrock et al., 1995) larval stage -- adult stage     (Kerrebrock et al., 1995) oogenesis & adult stage | female   ovary   (Kerrebrock et al., 1995) spermatogenesis & adult stage   testis   (Kerrebrock et al., 1995)
Additional Descriptive Data
	The 1.6kb mei-S332 transcript is detected in third instar larvae, in pupae, and in the testis of adult males. It is the most abundant mei-S332@ transcript in the testis. (Kerrebrock et al., 1995)
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
Additional Descriptive Data
	A fusion of mei-S332 to Avic\GFP was used to localize mei-S332 protein in the cell. In early prophase I, mei-S332 is found in the cytoplasm. Protein is first observed on distinct sites on the chromosomes late in prometaphase I. During anaphase I, these sites can be identified as centromeres. The protein stays on the centromeres through metaphase II and is no longer detected in early anaphase II. (Kerrebrock et al., 1995)
Marker for
Subcellular Localization
CV Term	meiotic chromosome centromere (Kerrebrock et al., 1995)
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0002715    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0002715 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of very low expression. Peak expression observed within 00-12 hour embryonic stages, during early pupal stages, in adult male stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0002715 expression level Developmental Stage   Expression Level embryo 00-02hr    2150 embryo 02-04hr    2357 embryo 04-06hr    2009 embryo 06-08hr    2348 embryo 08-10hr    1846 embryo 10-12hr    943 embryo 12-14hr    778 embryo 14-16hr    592 embryo 16-18hr    569 embryo 18-20hr    345 embryo 20-22hr    735 embryo 22-24hr    626 larva L1    65 larva L2    80 larva L3 12hr old    84 larva L3 puffstage 1-2    253 larva L3 puffstage 3-6    500 larva L3 puffstage 7-9    656 white prepupae new    609 white prepupae 12hr    1078 white prepupae 24hr    1420 pupae 2d postWPP    1274 pupae 3d postWPP    1179 pupae 4d postWPP    834 adult male 01day    1292 adult male 05day    1700 adult male 30day    1651 adult female 01day    435 adult female 05day    972 adult female 30day    1032 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (2150) embryo 02-04hr  (2357) embryo 04-06hr  (2009) embryo 06-08hr  (2348) embryo 08-10hr  (1846) embryo 10-12hr  (943) embryo 12-14hr  (778) embryo 14-16hr  (592) embryo 16-18hr  (569) embryo 18-20hr  (345) embryo 20-22hr  (735) embryo 22-24hr  (626) larva L1    65 larva L2    80 larva L3 12hr old    84 larva L3 puffstage 1-2  (253) larva L3 puffstage 3-6  (500) larva L3 puffstage 7-9  (656) white prepupae new  (609) white prepupae 12hr  (1078) white prepupae 24hr  (1420) pupae 2d postWPP  (1274) pupae 3d postWPP  (1179) pupae 4d postWPP  (834) adult male 01day  (1292) adult male 05day  (1700) adult male 30day  (1651) adult female 01day  (435) adult female 05day  (972) adult female 30day  (1032) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (2150) embryo 02-04hr  (2357) embryo 04-06hr  (2009) embryo 06-08hr  (2348) embryo 08-10hr  (1846) embryo 10-12hr    943 embryo 12-14hr    778 embryo 14-16hr    592 embryo 16-18hr    569 embryo 18-20hr    345 embryo 20-22hr    735 embryo 22-24hr    626 larva L1    65 larva L2    80 larva L3 12hr old    84 larva L3 puffstage 1-2    253 larva L3 puffstage 3-6    500 larva L3 puffstage 7-9    656 white prepupae new    609 white prepupae 12hr    1078 white prepupae 24hr  1420 pupae 2d postWPP    1274 pupae 3d postWPP    1179 pupae 4d postWPP    834 adult male 01day    1292 adult male 05day  (1700) adult male 30day  (1651) adult female 01day    435 adult female 05day    972 adult female 30day    1032 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    2150 embryo 02-04hr    2357 embryo 04-06hr    2009 embryo 06-08hr    2348 embryo 08-10hr    1846 embryo 10-12hr    943 embryo 12-14hr    778 embryo 14-16hr    592 embryo 16-18hr    569 embryo 18-20hr    345 embryo 20-22hr    735 embryo 22-24hr    626 larva L1    65 larva L2    80 larva L3 12hr old    84 larva L3 puffstage 1-2    253 larva L3 puffstage 3-6    500 larva L3 puffstage 7-9    656 white prepupae new    609 white prepupae 12hr    1078 white prepupae 24hr    1420 pupae 2d postWPP    1274 pupae 3d postWPP    1179 pupae 4d postWPP    834 adult male 01day    1292 adult male 05day    1700 adult male 30day    1651 adult female 01day    435 adult female 05day    972 adult female 30day    1032 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    2150 embryo 02-04hr    2357 embryo 04-06hr    2009 embryo 06-08hr    2348 embryo 08-10hr    1846 embryo 10-12hr    943 embryo 12-14hr    778 embryo 14-16hr    592 embryo 16-18hr    569 embryo 18-20hr    345 embryo 20-22hr    735 embryo 22-24hr    626 larva L1    65 larva L2    80 larva L3 12hr old    84 larva L3 puffstage 1-2    253 larva L3 puffstage 3-6    500 larva L3 puffstage 7-9    656 white prepupae new    609 white prepupae 12hr    1078 white prepupae 24hr    1420 pupae 2d postWPP    1274 pupae 3d postWPP    1179 pupae 4d postWPP    834 adult male 01day    1292 adult male 05day    1700 adult male 30day    1651 adult female 01day    435 adult female 05day    972 adult female 30day    1032 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0002715 expression level Developmental Stage   Expression Level embryo 00-02hr    2150 embryo 02-04hr    2357 embryo 04-06hr    2009 embryo 06-08hr    2348 embryo 08-10hr    1846 embryo 10-12hr    943 embryo 12-14hr    778 embryo 14-16hr    592 embryo 16-18hr    569 embryo 18-20hr    345 embryo 20-22hr    735 embryo 22-24hr    626 larva L1    65 larva L2    80 larva L3 12hr old    84 larva L3 puffstage 1-2    253 larva L3 puffstage 3-6    500 larva L3 puffstage 7-9    656 white prepupae new    609 white prepupae 12hr    1078 white prepupae 24hr    1420 pupae 2d postWPP    1274 pupae 3d postWPP    1179 pupae 4d postWPP    834 adult male 01day    1292 adult male 05day    1700 adult male 30day    1651 adult female 01day    435 adult female 05day    972 adult female 30day    1032 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (2150) embryo 02-04hr  (2357) embryo 04-06hr  (2009) embryo 06-08hr  (2348) embryo 08-10hr  (1846) embryo 10-12hr  (943) embryo 12-14hr  (778) embryo 14-16hr  (592) embryo 16-18hr  (569) embryo 18-20hr  (345) embryo 20-22hr  (735) embryo 22-24hr  (626) larva L1    65 larva L2    80 larva L3 12hr old    84 larva L3 puffstage 1-2  (253) larva L3 puffstage 3-6  (500) larva L3 puffstage 7-9  (656) white prepupae new  (609) white prepupae 12hr  (1078) white prepupae 24hr  (1420) pupae 2d postWPP  (1274) pupae 3d postWPP  (1179) pupae 4d postWPP  (834) adult male 01day  (1292) adult male 05day  (1700) adult male 30day  (1651) adult female 01day  (435) adult female 05day  (972) adult female 30day  (1032) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  2150 embryo 02-04hr  2357 embryo 04-06hr  2009 embryo 06-08hr  2348 embryo 08-10hr  1846 embryo 10-12hr    943 embryo 12-14hr    778 embryo 14-16hr    592 embryo 16-18hr    569 embryo 18-20hr    345 embryo 20-22hr    735 embryo 22-24hr    626 larva L1    65 larva L2    80 larva L3 12hr old    84 larva L3 puffstage 1-2    253 larva L3 puffstage 3-6    500 larva L3 puffstage 7-9    656 white prepupae new    609 white prepupae 12hr    1078 white prepupae 24hr  1420 pupae 2d postWPP    1274 pupae 3d postWPP    1179 pupae 4d postWPP    834 adult male 01day    1292 adult male 05day  1700 adult male 30day  1651 adult female 01day    435 adult female 05day    972 adult female 30day    1032 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    2150 embryo 02-04hr    2357 embryo 04-06hr    2009 embryo 06-08hr    2348 embryo 08-10hr    1846 embryo 10-12hr    943 embryo 12-14hr    778 embryo 14-16hr    592 embryo 16-18hr    569 embryo 18-20hr    345 embryo 20-22hr    735 embryo 22-24hr    626 larva L1    65 larva L2    80 larva L3 12hr old    84 larva L3 puffstage 1-2    253 larva L3 puffstage 3-6    500 larva L3 puffstage 7-9    656 white prepupae new    609 white prepupae 12hr    1078 white prepupae 24hr    1420 pupae 2d postWPP    1274 pupae 3d postWPP    1179 pupae 4d postWPP    834 adult male 01day    1292 adult male 05day    1700 adult male 30day    1651 adult female 01day    435 adult female 05day    972 adult female 30day    1032 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    2150 embryo 02-04hr    2357 embryo 04-06hr    2009 embryo 06-08hr    2348 embryo 08-10hr    1846 embryo 10-12hr    943 embryo 12-14hr    778 embryo 14-16hr    592 embryo 16-18hr    569 embryo 18-20hr    345 embryo 20-22hr    735 embryo 22-24hr    626 larva L1    65 larva L2    80 larva L3 12hr old    84 larva L3 puffstage 1-2    253 larva L3 puffstage 3-6    500 larva L3 puffstage 7-9    656 white prepupae new    609 white prepupae 12hr    1078 white prepupae 24hr    1420 pupae 2d postWPP    1274 pupae 3d postWPP    1179 pupae 4d postWPP    834 adult male 01day    1292 adult male 05day    1700 adult male 30day    1651 adult female 01day    435 adult female 05day    972 adult female 30day    1032 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0002715    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0002715 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: larval central nervous system, adult ovary, adult testis. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0002715 expression level Tissue   Expression Level Larval Central Nervous System    190.775 Larval Midgut no informative data Larval Hindgut    14.1 Larval Malpighian Tubules    20.1 Larval Fat Body no informative data Larval Salivary Gland no informative data Larval Trachea    29.775 Larval Carcass    13 Adult Head    11.2 Adult Eye    13.375 Adult Brain    24.9 Adult Thoracic-Abdominal Ganglion    29.6 Adult Crop    21.8 Adult Midgut    17.1 Adult Hindgut no informative data Adult Malpighian Tubules    9.5 Adult Fat Body    7.4 Adult Salivary Gland no informative data Adult Heart    8.55 Adult VirginFemale Spermatheca    4.7 Adult InseminatedFemale Spermatheca    5.1 Adult Ovary    211.1 Adult Testis    349.4 Adult Male Accessory Gland    6.8 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    190.775 Larval Midgut no informative data Larval Hindgut    14.1 Larval Malpighian Tubules    20.1 Larval Fat Body no informative data Larval Salivary Gland no informative data Larval Trachea    29.775 Larval Carcass    13 Adult Head    11.2 Adult Eye    13.375 Adult Brain    24.9 Adult Thoracic-Abdominal Ganglion    29.6 Adult Crop    21.8 Adult Midgut    17.1 Adult Hindgut no informative data Adult Malpighian Tubules    9.5 Adult Fat Body    7.4 Adult Salivary Gland no informative data Adult Heart    8.55 Adult VirginFemale Spermatheca    4.7 Adult InseminatedFemale Spermatheca    5.1 Adult Ovary    211.1 Adult Testis    349.4 Adult Male Accessory Gland    6.8 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    190.775 Larval Midgut no informative data Larval Hindgut    14.1 Larval Malpighian Tubules    20.1 Larval Fat Body no informative data Larval Salivary Gland no informative data Larval Trachea    29.775 Larval Carcass    13 Adult Head    11.2 Adult Eye    13.375 Adult Brain    24.9 Adult Thoracic-Abdominal Ganglion    29.6 Adult Crop    21.8 Adult Midgut    17.1 Adult Hindgut no informative data Adult Malpighian Tubules    9.5 Adult Fat Body    7.4 Adult Salivary Gland no informative data Adult Heart    8.55 Adult VirginFemale Spermatheca    4.7 Adult InseminatedFemale Spermatheca    5.1 Adult Ovary    211.1 Adult Testis    349.4 Adult Male Accessory Gland    6.8 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    190.775 Larval Midgut no informative data Larval Hindgut    14.1 Larval Malpighian Tubules    20.1 Larval Fat Body no informative data Larval Salivary Gland no informative data Larval Trachea    29.775 Larval Carcass    13 Adult Head    11.2 Adult Eye    13.375 Adult Brain    24.9 Adult Thoracic-Abdominal Ganglion    29.6 Adult Crop    21.8 Adult Midgut    17.1 Adult Hindgut no informative data Adult Malpighian Tubules    9.5 Adult Fat Body    7.4 Adult Salivary Gland no informative data Adult Heart    8.55 Adult VirginFemale Spermatheca    4.7 Adult InseminatedFemale Spermatheca    5.1 Adult Ovary    211.1 Adult Testis    349.4 Adult Male Accessory Gland    6.8 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0002715 expression level Tissue   Expression Level Larval Central Nervous System    190.775 Larval Midgut no informative data Larval Hindgut    14.1 Larval Malpighian Tubules    20.1 Larval Fat Body no informative data Larval Salivary Gland no informative data Larval Trachea    29.775 Larval Carcass    13 Adult Head    11.2 Adult Eye    13.375 Adult Brain    24.9 Adult Thoracic-Abdominal Ganglion    29.6 Adult Crop    21.8 Adult Midgut    17.1 Adult Hindgut no informative data Adult Malpighian Tubules    9.5 Adult Fat Body    7.4 Adult Salivary Gland no informative data Adult Heart    8.55 Adult VirginFemale Spermatheca    4.7 Adult InseminatedFemale Spermatheca    5.1 Adult Ovary    211.1 Adult Testis    349.4 Adult Male Accessory Gland    6.8 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    190.775 Larval Midgut no informative data Larval Hindgut    14.1 Larval Malpighian Tubules    20.1 Larval Fat Body no informative data Larval Salivary Gland no informative data Larval Trachea    29.775 Larval Carcass    13 Adult Head    11.2 Adult Eye    13.375 Adult Brain    24.9 Adult Thoracic-Abdominal Ganglion    29.6 Adult Crop    21.8 Adult Midgut    17.1 Adult Hindgut no informative data Adult Malpighian Tubules    9.5 Adult Fat Body    7.4 Adult Salivary Gland no informative data Adult Heart    8.55 Adult VirginFemale Spermatheca    4.7 Adult InseminatedFemale Spermatheca    5.1 Adult Ovary    211.1 Adult Testis    349.4 Adult Male Accessory Gland    6.8 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    190.775 Larval Midgut no informative data Larval Hindgut    14.1 Larval Malpighian Tubules    20.1 Larval Fat Body no informative data Larval Salivary Gland no informative data Larval Trachea    29.775 Larval Carcass    13 Adult Head    11.2 Adult Eye    13.375 Adult Brain    24.9 Adult Thoracic-Abdominal Ganglion    29.6 Adult Crop    21.8 Adult Midgut    17.1 Adult Hindgut no informative data Adult Malpighian Tubules    9.5 Adult Fat Body    7.4 Adult Salivary Gland no informative data Adult Heart    8.55 Adult VirginFemale Spermatheca    4.7 Adult InseminatedFemale Spermatheca    5.1 Adult Ovary    211.1 Adult Testis    349.4 Adult Male Accessory Gland    6.8 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    190.775 Larval Midgut no informative data Larval Hindgut    14.1 Larval Malpighian Tubules    20.1 Larval Fat Body no informative data Larval Salivary Gland no informative data Larval Trachea    29.775 Larval Carcass    13 Adult Head    11.2 Adult Eye    13.375 Adult Brain    24.9 Adult Thoracic-Abdominal Ganglion    29.6 Adult Crop    21.8 Adult Midgut    17.1 Adult Hindgut no informative data Adult Malpighian Tubules    9.5 Adult Fat Body    7.4 Adult Salivary Gland no informative data Adult Heart    8.55 Adult VirginFemale Spermatheca    4.7 Adult InseminatedFemale Spermatheca    5.1 Adult Ovary    211.1 Adult Testis    349.4 Adult Male Accessory Gland    6.8 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut no informative data Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body no informative data Larval Salivary Gland no informative data Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut no informative data Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland no informative data Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass no informative data FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    11.2   NA  Eye    13.375   NA  Brain    24.9   190.775  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    29.6   NA  Crop    21.8   no informative data  Midgut    17.1   14.1  Hindgut    no informative data   20.1  Malpighian Tubules    9.5   no informative data  Fat Body    7.4   no informative data  Salivary Gland    no informative data   NA  Heart    8.55   29.775  Trachea    NA   NA  VirginFemale Spermatheca    4.7   NA  InseminatedFemale Spermatheca    5.1   NA  Ovary    211.1   NA  Testis    349.4   NA  Male Accessory Gland    6.8   13  Carcass    no informative data modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_21
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0002715 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG5303-RA FlyExpress - Embryonic expression images (BDGP data) • Show all FlyExpress processed images for mei-S332 Stages(s) 1-3 Stages(s) 4-6 Stages(s) 13-16
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal, with Scer\GAL4hs.PB mei-S332Scer\UAS.T:Avic\GFP-S65T viable mei-S3321 mei-S33204 viable, with Scer\GAL4pnr-MD237 mei-S332GD5934 Sterility Allele male sterile mei-S3321 mei-S3324 mei-S3327 mei-S3328 Other Phenotypes Allele increased cell death, with Scer\GAL469B mei-S332Scer\UAS.T:Avic\GFP-S65T meiotic cell cycle defective mei-S3321 mei-S3327 meiotic cell cycle defective | recessive mei-S3321 mei-S3322 mei-S3323 mei-S3324 mei-S3325 mei-S3326 mei-S3327 mei-S3328 mei-S3329 mei-S33210 meiotic cell cycle defective | semidominant mei-S3321 mitotic cell cycle defective mei-S3321 mei-S3322 mei-S3323 mei-S3324 mei-S3326 mei-S3327 mei-S3328 wild-type mei-S332+t5.6 mei-S332+t8.6 mei-S332T:Avic\GFP Phenotype manifest in Allele imaginal disc, with Scer\GAL4hs.PB mei-S332Scer\UAS.T:Avic\GFP-S65T meiosis II | female mei-S33210 mei-S3326 mei-S3327 mei-S3329 meiosis II | male mei-S33210 mei-S3327 mei-S3328 mei-S3329 mitosis mei-S3328 neuroblast & mitotic cell cycle, with Scer\GAL469B mei-S332Scer\UAS.T:Avic\GFP-S65T neuroblast & mitotic cell cycle (with Df(2R)X58-6) mei-S3327 wing disc, with Scer\GAL4hs.PB mei-S332Scer\UAS.T:Avic\GFP-S65T
Classical Alleles ( 13 )
For All Classical Alleles Show
Allele of mei-S332 Class Mutagen Stocks Known lesion mei-S3321 loss of function allele, amorphic allele - genetic evidence spontaneous natural population ethyl methanesulfonate 4 Yes mei-S33204 1 Yes mei-S332BG01030 P-element activity 1 -- mei-S3327 amorphic allele - genetic evidence ethyl methanesulfonate 0 Yes mei-S33210 0 Yes mei-S3322 hypomorphic allele - genetic evidence ethyl methanesulfonate 0 Yes mei-S3323 hypomorphic allele - genetic evidence ethyl methanesulfonate 0 Yes mei-S3324 ethyl methanesulfonate 0 Yes mei-S3325 0 Yes mei-S3326 hypomorphic allele - genetic evidence ethyl methanesulfonate 0 Yes mei-S3328 hypomorphic allele - genetic evidence ethyl methanesulfonate 0 Yes mei-S3329 0 Yes mei-S332unspecified 0 --
Alleles Carried on Transgenic Constructs ( 22 )
For All Alleles Carried on Transgenic Constructs Show
Allele of mei-S332 Class Mutagen Stocks Known lesion mei-S332GD5934 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes mei-S332KK107238 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes mei-S332+t5.6 in vitro construct - genomic fragment 0 Yes mei-S332+t8.6 in vitro construct - genomic fragment 0 Yes mei-S332arm.T:Avic\GFP-m6 in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes mei-S332S234A.arm.T:Avic\GFP-m6 in vitro construct - site directed mutagenesis 0 Yes mei-S332S234A.T331A.arm.T:Avic\GFP-m6 in vitro construct - site directed mutagenesis 0 Yes mei-S332Scer\UAS.T:Avic\GFP-S65T in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes mei-S332T331A.arm.T:Avic\GFP-m6 in vitro construct - site directed mutagenesis 0 Yes mei-S332T:Avic\GFP in vitro construct 0 Yes mei-S332T:Hsap\MYC in vitro construct - regulatory fusion 0 Yes mei-S332Δa.arm.T:Avic\GFP-m6 in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes mei-S332Δb.arm.T:Avic\GFP-EGFP in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes mei-S332Δc.arm.T:Avic\GFP-m6 in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes mei-S332Δd.arm.T:Avic\GFP-m6 in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes mei-S332Δe.arm.T:Avic\GFP-m6 in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes mei-S332Δf.arm.T:Avic\GFP-m6 in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes mei-S332Δg.arm.T:Avic\GFP-EGFP in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes mei-S332Δh.arm.T:Avic\GFP-EGFP in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes mei-S332Δi.arm.T:Avic\GFP-EGFP in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes mei-S332Δj.arm.T:Avic\GFP-m6 in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes mei-S332Δk.arm.T:Avic\GFP-m6 in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(2R)Exel6078 (Ryder, 2004.4.26) Df(2R)Exel7170 (Ryder, 2004.4.26) Df(2R)R1-8 (Kerrebrock et al., 1995) Df(2R)X58-5 (Kerrebrock et al., 1995) Df(2R)X58-6 (Kerrebrock et al., 1992, Kerrebrock et al., 1995) Df(2R)X58-7 (Kerrebrock et al., 1995) Df(2R)X58-8 (Kerrebrock et al., 1995) Df(2R)X58-11 (Kerrebrock et al., 1995) In(2LR)dppt24Ldppd75R (Kerrebrock et al., 1995)
Not disrupted in	Df(2R)X58-1 (Kerrebrock et al., 1995) Df(2R)X58-2 (Kerrebrock et al., 1995) Df(2R)X58-3 (Kerrebrock et al., 1995) Df(2R)X58-12 (Kerrebrock et al., 1995)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD5934} NA P{KK107238} NA P{UAS-GFP:mei-S332} NA characterization construct P{5.6KKmei-S332} NA P{8.6RRmei-S332} NA P{mei-S332T:Hsap\MYC} NA P{mei-S332-GFP} NA P{w+cos1-5} NA P{w+cos1-12} NA P{w+cos4-4} NA
Insertions
	Type of insertions Name Expression data miscellaneous insertions ?{}mei-S3321 NA P{GT1}mei-S332BG01030 NA P{UAST-YFP.Rab1.S25N}mei-S33204 NA
Gene Ontology: Function, Process & Cellular Component ( 7 unique terms )
	There is no information supporting a molecular function term for this gene. (Based on a review of available data before: 2006)
Terms Based on Experimental Evidence ( 6 terms )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
female meiosis inferred from mutant phenotype (Sandler et al., 1968) male meiosis inferred from mutant phenotype (Sandler et al., 1968) male meiosis sister chromatid cohesion inferred from expression pattern (Kerrebrock et al., 1995) sister chromatid cohesion inferred from mutant phenotype (Tang et al., 1998)
Cellular Component
CV term Evidence References
chromosome inferred from direct assay (Blower and Karpen, 2001) condensed nuclear chromosome, centromeric region inferred from direct assay (Kerrebrock et al., 1995)
Terms Based on Predictions or Assertions ( 2 terms )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
meiotic metaphase I traceable author statement (Blower and Karpen, 2001) sister chromatid cohesion traceable author statement (Blower and Karpen, 2001)
Cellular Component ( 0 terms)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions mei-S332 allele Gene References mei-S3321 ord (Bickel et al., 1998)
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 63143 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0002715 DroID - A comprehensive database of gene and protein interactions. • FBgn0002715 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 37523
Orthologs
Genome-wide drosophilid orthologs	Dana\GF13289 Dere\GG22163 Dgri\GH20552 Dmoj\GI20753 Dper\GL11778 Dpse\GA18794 Dsec\GM15884 Dsim\GD11646 Dvir\GJ21848 Dwil\GK15937 Dyak\GE12243
Curated drosophilid orthologs	Dpse\GA18794   Dsim\mei-S332 (Anderson et al., 2009)
Linkouts	OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • FBgn0230002 FBgn0217939 FBgn0207629 FBgn0183386 FBgn0170800 FBgn0078794 FBgn0149387 FBgn0143488 FBgn0141560 FBgn0114337
Stocks & Reagents
Stocks Listed in FlyBase ( 8 )
Bloomington	12776 w1118; P{GT1}mei-S332BG01030 23236 y1 w*; P{UAST-YFP.Rab1.S25N}mei-S33204 671 y1/Dp(1;Y)y+; cn1 mei-S3321/SM1 1344 y1/Dp(1;Y)y+; cn1 mei-S3321 ord1/SM1; svspa-pol
Kyoto	106032 y1/Dp(1;Y)y+; cn1 mei-S3321/SM1 106281 y1/Dp(1;Y)y+; cn1 mei-S3321 ord1/SM1; svspa-pol
VDRC	v104304 P{KK107238}VIE-260B v16865 w1118; P{GD5934}v16865/TM3
Genomic Clones ( 1 )
	BACR02O12 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 84 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	LD33081
Other clones	DPiM_LD33081
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	LD03136 LD07773 LD13774 LD28223 LD40772 LD41922 LD43518 LP13134 RE03160 RE33428 RE46653 RE65345
Other clones	79437 122100 180776 bs07g10 Dmel_neb_015458_0925_2951 EK209523 EK245419 EK285912 RP003012301 RP003016096 RP003037553 RP003045517 RP003052282 RP003055791 RP003064517 RP003070215 RP003079381 RP003112939 RP003126345 RP003134056 RP003140354 RP003150992 RP003152089 RP003163943 RP003174740 RP003176904 RP003179803 RP003186830 RP003233556 RP003234513 RP003240388 RP003240523 RP003250332 RP003285162 RP003306419 RP003338786 RP003348736 RP003356647 RP003371247 RP003381656 RP003381892 RP003383128 RP003397348 RP003398895 RP003402911 RP003419421 RP003425618 RP003430723 RP003433479 RP003435337 RP003437723 RP003442680 RP003443814 RP003456722 RP003457603 RP003458109 RP003474779 RP003475202 RP003481991 RP003492207 RP003492809 RP003501511 RP003516386 RP003517301 RP003530573 RP003547854 RP003553641 RP003621227 RP003629172 RP003650334
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0002715 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 37523
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: mei-S332 CG5303 (Milshina, 1999.11)
Source for database merge of	Source for merge of: mei-S332 BEST:LD13774 (Rana, 2004.7.8)
Additional comments
Other Comments
	mei-S332 function is necessary for normal minichromosome transmission. (Lopez et al., 2000) A balance between the activity of mei-S332 and ord is required for proper regulation of meiotic cohesion. (Bickel et al., 1998) Flies that are double mutant for mei-S332 and ord are viable and fertile. ord is epistatic to mei-S332. (Bickel et al., 1998) mei-S332 protein assembles into a multimeric protein complex that localises to the centromeric regions during prometaphase. (Tang et al., 1998) mei-S332 is required for the maintenance of sister-chromatid cohesion until anaphase rather than for the establishment of sister-chromatid cohesion in S phase. (Tang et al., 1998) mei-S332 is necessary for chromosome segregation and can interact specifically with the centromere. (Cook et al., 1997) mei-S332 is required to maintain sister-chromatid cohesion during meiosis in both males an females. Mutations result in precocious separation of sisters after the metaphase I/anaphase I transition when cohesion is restricted to the kinetochore region. (Bickel et al., 1995) A fusion of mei-S332 to Avic\GFP is fully functional and localises specifically to the centromere region of meiotic chromosomes. When sister chromatids separate at anaphase II mei-S332-Avic\GFP disappears from the chromosomes suggesting that the destruction or release of this protein is required for sister-chromatid separation. (Kerrebrock et al., 1995) The earliest manifestation of the requirement for mei-S332 can be observed cytologically at mid-late anaphase I. Mutations in mei-S332 do not effect recombination so the locus is not required for homologous pairing. The mei-S332 gene product is not absolutely required during mitosis. (Kerrebrock et al., 1992) Mutations at ord cause precocious separation of sister chromatids, at earlier stages than do mutations at mei-S332. (Miyazaki and Orr-Weaver, 1992) mei-S332 is required for proper chromosome segregation during meiosis in both males and females. Mutant individuals display separation of sister chromatids in mid-late anaphase I. (Kerrebrock and Orr-Weaver, 1990)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_057286 RefSeq (Proteins) • NP_476634 DDBJ / EMBL / GenBank • AA440503 AA978893 AAA87038 AAF46802 AAL13862 AC003054 AW943164 AY058633 BH023723 U36583 Entrez Gene - A searchable database of RefSeq genes. • 37523 UniProtKB/Swiss-Prot • Q24141
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Shugoshin, C-terminal (IPR011515) Shugoshin, N-terminal (IPR011516)
Linkouts
	BioGRID - A database of protein and genetic interactions • 63143 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0002715 DroID - A comprehensive database of gene and protein interactions. • FBgn0002715 DRSC - Results from RNAi screens. • FBgn0002715 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0002715 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG5303-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0002715 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 37523 Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution • /newgene/mei332-1.htm InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 37523 modMine - Data generated by the modENCODE project. • FBgn0002715 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • FBgn0230002 FBgn0217939 FBgn0207629 FBgn0183386 FBgn0170800 FBgn0078794 FBgn0149387 FBgn0143488 FBgn0141560 FBgn0114337
Synonyms & Secondary IDs ( 14 )
Reported As
Symbol Synonym	BEST:LD13774   CG5303 (Keleman et al., 2009.8.5) mei-S322 (Liu and Lengyel, 2000, Zhang et al., 2007) meiS322 (Fuller, 1993) MEI-S322 (Delcros et al., 2006) MEI-S332 (Bettencourt-Dias et al., 2004, Erhardt et al., 2005, Dej and Orr-Weaver, 2001, LeBlanc et al., 1999, Moore et al., 1998, Cohen et al., 2007, Rivera, 2006, Garcia et al., 2007, Valdeolmillos et al., 2004, Nogueira et al., 2008, Jang et al., 2005, Heun et al., 2006, Resnick et al., 2006, Wu et al., 2008, Resnick et al., 2009) MeiS332 (Petronczki et al., 2003, Compton, 2002, Nasmyth, 1999) mei-s332 (Rieder and Cole, 1999) meiS332 (Philp, 1998, Reis et al., 2011) mei-S332 (Lake and Hawley, 2005, Clarke et al., 2005, Mukai et al., 2006, Kerrebrock et al., 1995, Yan et al., 2010, Cayirlioglu et al., 2003, Georlette et al., 2007, Emberly et al., 2008, Anderson et al., 2009, Wen et al., 2008, Magalhaes et al., 2007) Mei-S332 (Wen et al., 2008)
Name Synonym	meiotic from Salaria 332 (Mukai et al., 2006) meiotic from via Salaria 332 (Sandler et al., 1968, Magwire et al., 2010) Shugoshin (Wen et al., 2008)
Secondary FlyBase IDs
	FBgn0046271
References ( 116 )
Generate a list of	All references relating to this gene ( 116 )
List References by type	Research paper  ( 58 ) Supplementary material  ( 4 ) Review  ( 22 ) Personal communication to FlyBase  ( 6 ) Abstract  ( 18 ) FlyBase analysis  ( 3 ) Conference report  ( 1 ) Curated genome annotation  ( 1 ) Computer file  ( 2 ) Automatic genome annotation  ( 1 )
Recent research papers ( 3 )
	Reis et al., 2011, PLoS ONE 6(3): e17512 Drosophila Genes That Affect Meiosis Duration Are among the Meiosis Related Genes That Are More Often Found Duplicated. [FBrf0213266] Magwire et al., 2010, PLoS Genet. 6(7): e1001037 Quantitative and molecular genetic analyses of mutations increasing Drosophila life span. [FBrf0211465] Yan et al., 2010, J. Cell Biol. 188(3): 335--349 SOLO: a meiotic protein required for centromere cohesion, coorientation, and SMC1 localization in Drosophila melanogaster. [FBrf0209923] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2010 Show reviews ...