FlyBase Gene Report: Dmel\mei-W68

General Information

Symbol

Dmel\mei-W68

Species

D. melanogaster

Name

meiotic W68

Annotation Symbol

CG7753

Feature Type

protein_coding_gene

FlyBase ID

FBgn0002716

Gene Model Status

Current

Stock Availability

10 publicly available

Enzyme Name (EC)

DNA topoisomerase (ATP-hydrolyzing) (5.6.2.2)

Gene Summary

meiotic W68 (mei-W68) encodes a protein thought to form a dimer with the TopoVIA subunit encoded by mei-P22 and is required for the formation of double strand breaks during meiosis. [Date last reviewed: 2019-03-14] (FlyBase Gene Snapshot)

All Summaries

Gene Snapshot
Alliance
Auto summary
Gene Group
UniProtKB
Red Book
Interactive Fly

Also Known As

spo11, l(2)k05603

Key Links

Genomic Location

Cytogenetic map

56D9-56D9

Sequence location

2R:19,456,170..19,459,523 [+]

Recombination map

2-89

RefSeq locus

NT_033778 REGION:19456170..19459523

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse GBrowse

Help me choose

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

GO Summary Ribbons

Gene Ontology (GO) Annotations (12 terms)

Molecular Function (3 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (3 terms)

CV Term

Evidence

References

enables ATP binding

inferred from electronic annotation with InterPro:IPR013049

(assigned by InterPro )

(FlyBase Curators et al., 2004-)

enables DNA binding

inferred from biological aspect of ancestor with PANTHER:PTN000091176

(assigned by GO_Central )

(Gaudet et al., 2011)

enables DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity

inferred from electronic annotation with InterPro:IPR004085

(assigned by InterPro )

(FlyBase Curators et al., 2004-)

Biological Process (8 terms)

Terms Based on Experimental Evidence (6 terms)

CV Term

Evidence

References

involved_in early meiotic recombination nodule assembly

inferred from mutant phenotype

(Carpenter, 2003)

involved_in late meiotic recombination nodule assembly

inferred from mutant phenotype

(Carpenter, 2003)

involved_in meiotic DNA double-strand break processing

inferred from direct assay

(Joyce et al., 2011)

involved_in oocyte karyosome formation

inferred from genetic interaction with FLYBASE:Hus1-like; FB:FBgn0026417

(Peretz et al., 2009)

involved_in oogenesis

inferred from genetic interaction with FLYBASE:okr; FB:FBgn0002989, FLYBASE:p53; FB:FBgn0039044

(Lu et al., 2010)

involved_in reciprocal meiotic recombination

inferred from mutant phenotype

(Joyce and McKim, 2009, McKim et al., 1998)

Terms Based on Predictions or Assertions (4 terms)

CV Term

Evidence

References

involved_in DNA topological change

inferred from electronic annotation with InterPro:IPR004085

(assigned by InterPro )

(FlyBase Curators et al., 2004-)

involved_in meiotic DNA double-strand break formation

inferred from biological aspect of ancestor with PANTHER:PTN000091177

(assigned by GO_Central )

(Gaudet et al., 2011)

involved_in meiotic DNA double-strand break processing

inferred from biological aspect of ancestor with PANTHER:PTN000091177

(assigned by GO_Central )

(Gaudet et al., 2011)

involved_in reciprocal meiotic recombination

traceable author statement

(McKim et al., 2000, Shulman et al., 2000)

inferred from biological aspect of ancestor with PANTHER:PTN000091177

(assigned by GO_Central )

(Gaudet et al., 2011)

Cellular Component (1 term)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

is_active_in nuclear chromosome

inferred from biological aspect of ancestor with PANTHER:PTN000091177

(assigned by GO_Central )

(Gaudet et al., 2011)

Gene Group (FlyBase)

DNA TOPOISOMERASES TYPE II

Protein Family (UniProt)

Belongs to the TOP6A family. (Q7KPA5)

Protein Signatures (InterPro)

Catalytic Activity (EC)

Experimental Evidence

Predictions / Assertions

ATP-dependent breakage, passage and rejoining of double-stranded DNA (5.6.2.2)

Summaries

Gene Snapshot

Gene Group (FlyBase)

DNA TOPOISOMERASES TYPE II -: DNA topoisomerases perform topological transformations of DNA by generating a transient DNA break through which strand passage can occur. These enzymes are grouped into types I and II based on structure and mechanism: type II enzymes mediate strand transport through a double-strand DNA gate, coupled to ATP binding and hydrolysis. DNA topoisomerases have critical roles in DNA replication, transcription, recombination, repair, and chromatin remodeling. (Adapted from PMID:23495937.)

Protein Function (UniProtKB)

Required for meiotic recombination (PubMed:9744869). Together with mei-P22, mediates DNA cleavage that forms the double-strand breaks (DSB) that initiate meiotic recombination (By similarity).

(UniProt, Q7KPA5)

Phenotypic Description (Red Book; Lindsley and Zimm 1992)

mei-W68 (R.S. Hawley)

Females homozygous for mei-w68 show a complete absence of meiotic recombination (Baker, unpublished data). Ultrastructural studies of pachytene reveal an absence of chromosome condensation and little synaptonemal complex (Carpenter, cited in Baker et al., 1976). A less severe allele (mei-w68L1-Lindsley) reduces exchange to approximately 60% of control levels and also alters the distribution of residual exchanges. Analysis of mitotic chromosome behavior (Baker et al., 1978) suggests that the mei-w68+ gene product is also required in mitotic cells.

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\mei-W68 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure New Section

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry Q7KPA5)

If you don't see the viewer to the right, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Comments on Gene Model

Gene model reviewed during 5.48

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.44

Shares 5' UTR with upstream gene.

Gene model reviewed during 5.55

Sequence Ontology: Class of Gene

nuclear_gene

protein_coding_gene

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

mei-W68-RA

FBtr0086461

NM_206179

2300

331

Additional Transcript Data and Comments

Reported size (kB)

2.4, 2.3, 2.1 (northern blot)

(McKim and Hayashi-Hagihara, 1998)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

RefSeq ID

GenBank

mei-W68-PA

FBpp0085657

37.1

331

7.18

NP_995901

AAF57553

Polypeptides with Identical Sequences

There is only one protein coding transcript and one polypeptide associated with this gene

Additional Polypeptide Data and Comments

Reported size (kDa)

331 (aa)

(McKim and Hayashi-Hagihara, 1998)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Q7KPA5

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\mei-W68 using the Feature Mapper tool.

External Data

Crossreferences

Linkouts

Expression Data

Expression Summary Ribbons

Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.

For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.

Transcript Expression

northern blot

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage -- P-stage

organism

(McKim and Hayashi-Hagihara, 1998)

adult stage | female

(McKim and Hayashi-Hagihara, 1998)

germarium region 2

(McKim and Hayashi-Hagihara, 1998)

germarium region 3

(McKim and Hayashi-Hagihara, 1998)

adult stage | male

testis

(McKim and Hayashi-Hagihara, 1998)

Additional Descriptive Data

mei-W68 transcripts are detected in embryos, larvae, pupae, and adult females on northern blots. They are detected weakly in male testis. Transcripts are detected by in situ hybridization in germarium regions 2 and 3.

(McKim and Hayashi-Hagihara, 1998)

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

Expression Deduced from Reporters

Reporter: P{ST.lexA::HG}mei-W68^SE245

Stage

Tissue/Position (including subcellular localization)

Reference

wandering third instar larval stage

larval ventral nerve cord

(Bloomington Drosophila Stock Center, 2019)

embryonic/larval central nervous system

(Bloomington Drosophila Stock Center, 2019)

embryonic/larval fat body

(Bloomington Drosophila Stock Center, 2019)

embryonic/larval anterior midgut

(Bloomington Drosophila Stock Center, 2019)

High-Throughput Expression Data

Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\mei-W68 in GBrowse 2

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\mei-W68

View exonic expression by tissue for Dmel\mei-W68

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

2768853/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0002716

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0002716

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0002716

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG30132

Flygut - An atlas of the Drosophila adult midgut

FBgn0002716

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 20 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 3 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of mei-W68

Transgenic constructs containing regulatory region of mei-W68

Aberrations (Deficiencies and Duplications) ( 8 )

Inferred from experimentation ( 8 )

Gene disrupted in

Df(2R)LD3

(McKim and Hayashi-Hagihara, 1998)

Df(2R)LL4

(McKim and Hayashi-Hagihara, 1998)

Df(2R)LL5

(McKim and Hayashi-Hagihara, 1998)

Gene not disrupted in

Df(2R)017

(McKim and Hayashi-Hagihara, 1998)

Df(2R)AA21

(McKim and Hayashi-Hagihara, 1998)

Df(2R)E3578

(BDGP Project Members, 1994-1999)

Df(2R)P34

(McKim and Hayashi-Hagihara, 1998)

Df(2R)X58-7

(BDGP Project Members, 1994-1999)

Inferred from location ( 0 )

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

lethal | recessive

viable

mei-W68^k05603

viable, with Scer\GAL4^- :

mei-W68^EP1144

Other Phenotypes

Allele

abnormal cell cycle

mei-W68¹

abnormal meiotic cell cycle

abnormal meiotic cell cycle (with mei-W68¹)

mei-W68^L1

abnormal meiotic cell cycle (with mei-W68^L1)

abnormal meiotic cell cycle (with mei-W68^Z4472)

mei-W68^L1

abnormal meiotic cell cycle | female

wild-type, with Scer\GAL4^- :

mei-W68^EP899

Phenotype manifest in

Allele

early recombination nodule

germarium

mei-W68^2-0949

late recombination nodule

mei-W68¹

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v8.0)

Homo sapiens (Human) (1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Hsap\SPO11

14 of 15

Yes

Model Organism Orthologs (via DIOPT v8.0)

Mus musculus (laboratory mouse) (1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Mmus\Spo11

14 of 15

Yes

Rattus norvegicus (Norway rat) (1)

Rnor\Spo11

12 of 13

Yes

Xenopus tropicalis (Western clawed frog) (1)

Xtro\spo11

8 of 12

Yes

Danio rerio (Zebrafish) (1)

Drer\spo11

10 of 15

Yes

Caenorhabditis elegans (Nematode, roundworm) (1)

Cele\spo-11

13 of 15

Yes

Arabidopsis thaliana (thale-cress) (3)

Atha\RHL2

9 of 9

Yes

Atha\SPO11-2

7 of 9

Yes

Atha\ATSPO11-1

6 of 9

Yes

Saccharomyces cerevisiae (Brewer's yeast) (1)

Scer\SPO11

10 of 15

Yes

Schizosaccharomyces pombe (Fission yeast) (1)

Spom\rec12

10 of 12

Yes

Other Organism Orthologs (via OrthoDB)

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v8.0)

Drosophila melanogaster (Fruit fly) (0)

No records found.

Human Disease Associations

FlyBase Human Disease Model Reports

cancer, multiple, germline-specific genes

Disease Model Summary Ribbon

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Allele

Disease

Interaction

References

mei-W68^KK109695

ameliorates brain cancer

modeled by l(3)mbt^ts1

(Rossi et al., 2017)

Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

SPO11; SPO11 initiator of meiotic double stranded breaks

14 of 15

605114

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

esyN Network Diagram

Interactions Browser

Summary of Genetic Interactions

esyN Network Diagram

esyN Network Key:

Suppression

Enhancement

View in Interactions Browser

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

CycG

suppressible

mei-W68

(Nagel et al., 2012)

Gcna

suppressible

mei-W68

(Bhargava et al., 2020)

jnj

suppressible

mei-W68

(Tran et al., 2016)

mio

suppressible

mei-W68

(Iida and Lilly, 2004)

mus301

suppressible

mei-W68

(Ghabrial and Schupbach, 1999)

okr

suppressible

mei-W68

(Barbosa et al., 2007, Ghabrial and Schupbach, 1999)

suppressible

(Lu et al., 2010)

suppressible

(Barbosa et al., 2007)

spn-A

suppressible

mei-W68

(Barbosa et al., 2007, Staeva-Vieira et al., 2003)

spn-B

suppressible

mei-W68

(Liu et al., 2002, Liu et al., 2000, Ghabrial and Schupbach, 1999)

spn-D

suppressible

mei-W68

(Abdu et al., 2003)

tefu

suppressible

mei-W68

(Joyce et al., 2011)

External Data

Linkouts

BioGRID - A database of protein and genetic interactions.

77703

DroID - A comprehensive database of gene and protein interactions.

FBgn0002716

MIST (genetic) - An integrated Molecular Interaction Database

mei-W68

MIST (protein-protein) - An integrated Molecular Interaction Database

mei-W68

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

External Data

Linkouts

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

2-89

Cytogenetic map

56D9-56D9

Sequence location

2R:19,456,170..19,459,523 [+]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

56D9-56D9

Limits computationally determined from genome sequence between P{lacW}l(2)k00705^k00705&P{lacW}mei-W68^k05603 and P{EP}CG11007^EP736

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

56D-56D

(Hayashi-Hagihara, 1998.8.19)

56D8-56D10

(determined by in situ hybridisation)

(Spradling et al., 1999)

58D8-58D10

(determined by in situ hybridisation)

(BDGP Project Members, 1994-1999)

Experimentally Determined Recombination Data

Location

2-89

(FlyBase, 2016)

2-94.7

(Comeron et al., 2012)

2-94

Left of (cM)

(McKim and Hayashi-Hagihara, 1998)

(McKim, 1998.3.10)

Right of (cM)

(McKim, 1998.3.10)

(McKim and Hayashi-Hagihara, 1998)

Notes

Stocks and Reagents

Stocks (10)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Bloomington

4932

y¹/Dp(1;Y)y⁺; mei-W68¹/CyO

43460

w^*; P{GSV1}mei-W68^EP-J72.4 par-1^EP-J72.4

81527

w^*; P{ST.lexA::HG}mei-W68^SE245 par-1^SE245

10574

y¹ w^67c23; P{lacW}mei-W68^k05603 par-1^k05603/CyO

Kyoto

107952

y¹/Dp(1;Y)y⁺; mei-W68¹/CyO

108858

y¹ w^67c23; P{lacW}mei-W68^k05603/CyO

202741

y¹ w^67c23; P{GSV6}mei-W68^GS10670/SM1

111182

y^d2 w¹¹¹⁸ P{ey-FLP.N}2 P{5xglBS-lacZ.38-1}TPN1; P{neoFRT}42D P{lacW}mei-W68^k05603 /CyO y⁺

VDRC

v330154

P{VSH330154}attP40

v101798

P{KK109695}VIE-260B

Genomic Clones (24)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (21)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

RE47050

Other clones

RT05903

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0002716

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0002716

GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents

2768853

Antibody Information

Laboratory Generated Antibodies

Commercially Available Antibodies

Other Information

Relationship to Other Genes

Source for database identify of

Source for identity of: mei-W68 CG7753

(Milshina, 1999.11)

Source for database merge of

Additional comments

One or more of the processed transcripts for this gene share(s) untranslated sequences with a transcript of an adjacent gene, but encode(s) a single open reading frame (ORF). The non-overlapping ORFs that share untranslated sequences are represented by par-1 and mei-W68.

(FlyBase Genome Annotators, 2004)

mei-W68 shares a promoter and 5'-UTR with the N1 class of par-1 transcripts and the coding sequence of mei-W68 falls entirely within the first par-1 intron.

(Shulman et al., 2000)

Other Comments

Intragenic recombination at ry is used as an assay of the effects of mutation on meiotic crossing over.

(McKim et al., 1998)

Origin and Etymology

Discoverer

Etymology

Identification

External Crossreferences and Linkouts ( 40 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

2768853

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

Q7KPA5

UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information

Q7KPA5

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

Q7KPA5

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0002716

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

2768853/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0002716

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0002716

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0002716

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG30132

Flygut - An atlas of the Drosophila adult midgut

FBgn0002716

GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents

2768853

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

Dmel_CG7753

MARRVEL_MODEL - MARRVEL (model organism gene)

2768853

modMine - A data warehouse for the modENCODE project

FBgn0002716

Linkouts

ApoDroso - Functional genomic database for photoreceptor development, survival and function

10574-mei-W68[k05603]

BioGRID - A database of protein and genetic interactions.

77703

DroID - A comprehensive database of gene and protein interactions.

FBgn0002716

DRSC - Results frm RNAi screens

FBgn0002716

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0002716

FlyMine - An integrated database for Drosophila genomics

FBgn0002716

MIST (genetic) - An integrated Molecular Interaction Database

mei-W68

MIST (protein-protein) - An integrated Molecular Interaction Database

mei-W68

Synonyms and Secondary IDs (16)

Reported As

Symbol Synonym

CG30132

CG7753

(Ibaraki et al., 2021, Meadows, 2017.1.11, Keleman et al., 2009.8.5)

Mei-W68

(Clémot et al., 2018, Roelens et al., 2017, Lake et al., 2015, Hochwagen, 2006)

MeiW68

(Reis et al., 2011)

SPO11

(Rossi et al., 2017)

Spo-11

(Ferreira and Allard, 2015)

Spo11

(Wylie et al., 2016)

W68

(McKee et al., 2000)

l(2)k05603

(Palmer et al., 1999)

mei

(Mengoli et al., 2014)

mei W-68

(Santos, 1999)

mei-W68

(Chakravarti et al., 2022, Ibaraki et al., 2021, Gogia et al., 2020, Lake et al., 2019, Schüpbach, 2019, Wei et al., 2019, Hughes et al., 2018, Moskalev et al., 2018, Rossi et al., 2017, John et al., 2016, Lake et al., 2015, Tritto et al., 2015, Barclay et al., 2014, Weng et al., 2014, de Celis et al., 2013.9.11, Huang et al., 2013, Lake et al., 2013, Nagel et al., 2012, Joyce et al., 2011, Lake et al., 2011, Chubykin, 2010, Joyce and McKim, 2010, Lu et al., 2010, Meyer et al., 2010, Anderson et al., 2009, Bozas et al., 2009, Joyce and McKim, 2009, Klattenhoff et al., 2009, Peng and Karpen, 2009, Peretz et al., 2009, Wu et al., 2008, Barbosa et al., 2007, Garcia et al., 2007, Klattenhoff et al., 2007, McCaffrey et al., 2006, Mehrotra and McKim, 2006, Bhagat et al., 2004, Jang et al., 2003, McKim et al., 2000)

mei-w68

(Bhargava et al., 2020, Hsu et al., 2020, Tran et al., 2016)

meiW68

(Huynh and St. Johnston, 2004)

spo11

(Wylie et al., 2014, Lu et al., 2010)

Name Synonyms

meiotic W68

(John et al., 2016)

Secondary FlyBase IDs