FlyBase Gene Report: Dmel\mei-W68

General Information

Symbol

Dmel\mei-W68

Species

D. melanogaster

Name

meiotic W68

Annotation Symbol

CG7753

Feature Type

protein_coding_gene

FlyBase ID

FBgn0002716

Gene Model Status

Current

Stock Availability

9 publicly available

Enzyme Name (EC)

DNA topoisomerase (ATP-hydrolyzing) (5.99.1.3)

Gene Snapshot

Meiotic W68 is thought to form a dimer with the TopoVIA subunit mei-P22 and is required for the formation of double strand breaks during meiosis. [Date last reviewed: 2016-08-18]

Other Summaries

Auto summary
Gene Group
UniProtKB
Red Book
Interactive Fly

Also Known As

l(2)k05603

Key Links

Genomic Location

Cytogenetic map

56D9-56D9

Sequence location

2R:19,456,170..19,459,523 [+]

Recombination map

2-89

Sequence

Get Decorated FASTA

Genomic Maps

GBrowse JBrowse

Help me choose

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

NCBI Genome Data Viewer

UCSC Genome Browser

Ensembl Genome Browser

PopFly Genome Browser

GO Summary Ribbons

[Detailed GO annotations]

Families, Domains and Molecular Function

Gene Group Membership (FlyBase)

DNA TOPOISOMERASES

Protein Family (UniProt, Sequence Similarities)

Belongs to the TOP6A family. (Q7KPA5)

Protein Domains/Motifs

InterPro

Spo11/DNA topoisomerase VI subunit A; DNA topoisomerase VI, subunit A; Spo11/DNA topoisomerase VI, subunit A, N-terminal; Topoisomerase 6 subunit A/Spo11, TOPRIM domain; Spo11/DNA topoisomerase VI subunit A superfamily

Molecular Function (see GO section for details)

Experimental Evidence

Predictions / Assertions

ATP binding; DNA binding; DNA topoisomerase type II (ATP-hydrolyzing) activity; endodeoxyribonuclease activity, producing 3'-phosphomonoesters

Catalytic Activity (EC)

Experimental Evidence

Predictions / Assertions

ATP-dependent breakage, passage and rejoining of double-stranded DNA (5.99.1.3)

Summaries

Gene Group Membership

DNA TOPOISOMERASES -: DNA topoisomerases perform topological transformations of DNA by generating a transient DNA break through which strand passage can occur. These enzymes are grouped into types I and II based on structure and mechanism: type I enzymes carry out strand passage through a reversible single-strand break, whereas type II enzymes mediate strand transport through a double-strand DNA gate. DNA topoisomerases have critical roles in DNA replication, transcription, recombination, repair, and chromatin remodeling. (Adapted from PMID:23495937.)

UniProt Contributed Function Data

Required for meiotic recombination (PubMed:9744869). Together with mei-P22, mediates DNA cleavage that forms the double-strand breaks (DSB) that initiate meiotic recombination (By similarity).

(UniProt, Q7KPA5)

Phenotypic Description from the Red Book (Lindsley and Zimm 1992)

mei-W68 (R.S. Hawley)

Females homozygous for mei-w68 show a complete absence of meiotic recombination (Baker, unpublished data). Ultrastructural studies of pachytene reveal an absence of chromosome condensation and little synaptonemal complex (Carpenter, cited in Baker et al., 1976). A less severe allele (mei-w68L1-Lindsley) reduces exchange to approximately 60% of control levels and also alters the distribution of residual exchanges. Analysis of mitotic chromosome behavior (Baker et al., 1978) suggests that the mei-w68+ gene product is also required in mitotic cells.

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the GBrowse view of Dmel\mei-W68 or the JBrowse view of Dmel\mei-W68 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Comments on Gene Model

Gene model reviewed during 5.48

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.44

Shares 5' UTR with upstream gene.

Gene model reviewed during 5.55

Sequence Ontology: Class of Gene

nuclear_gene

protein_coding_gene

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

mei-W68-RA

FBtr0086461

NM_206179

2300

331

Additional Transcript Data and Comments

Reported size (kB)

2.4, 2.3, 2.1 (northern blot)

(McKim and Hayashi-Hagihara, 1998)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

RefSeq ID

GenBank

mei-W68-PA

FBpp0085657

37.1

331

7.18

NP_995901

AAF57553

Polypeptides with Identical Sequences

There is only one protein coding transcript and one polypeptide associated with this gene

Additional Polypeptide Data and Comments

Reported size (kDa)

331 (aa)

(McKim and Hayashi-Hagihara, 1998)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Q7KPA5

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\mei-W68 using the Feature Mapper tool.

External Data

Crossreferences

Linkouts

Gene Ontology (14 terms)

Molecular Function (4 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (4 terms)

CV Term

Evidence

References

ATP binding

inferred from electronic annotation with InterPro:IPR013049

(assigned by InterPro )

(FlyBase Curators et al., 2004-)

DNA binding

inferred from biological aspect of ancestor with PANTHER:PTN000091176

(assigned by GO_Central )

(Gaudet et al., 2011)

DNA topoisomerase type II (ATP-hydrolyzing) activity

inferred from electronic annotation with InterPro:IPR004085

(assigned by InterPro )

(FlyBase Curators et al., 2004-)

endodeoxyribonuclease activity, producing 3'-phosphomonoesters

inferred from biological aspect of ancestor with PANTHER:PTN000091176

(assigned by GO_Central )

(Gaudet et al., 2011)

Biological Process (9 terms)

Terms Based on Experimental Evidence (6 terms)

CV Term

Evidence

References

early meiotic recombination nodule assembly

inferred from mutant phenotype

(Carpenter, 2003)

late meiotic recombination nodule assembly

inferred from mutant phenotype

(Carpenter, 2003)

meiotic DNA double-strand break processing

inferred from direct assay

(Joyce et al., 2011)

oocyte karyosome formation

inferred from genetic interaction with FLYBASE:Hus1-like; FB:FBgn0026417

(Peretz et al., 2009)

oogenesis

inferred from genetic interaction with FLYBASE:okr; FB:FBgn0002989, FLYBASE:p53; FB:FBgn0039044

(Lu et al., 2010)

reciprocal meiotic recombination

inferred from mutant phenotype

(Joyce and McKim, 2009, McKim et al., 1998)

Terms Based on Predictions or Assertions (5 terms)

CV Term

Evidence

References

DNA catabolic process, endonucleolytic

inferred from electronic annotation with InterPro:IPR002815

(assigned by InterPro )

(FlyBase Curators et al., 2004-)

DNA topological change

inferred from electronic annotation with InterPro:IPR004085

(assigned by InterPro )

(FlyBase Curators et al., 2004-)

meiotic DNA double-strand break formation

inferred from biological aspect of ancestor with PANTHER:PTN000091177

(assigned by GO_Central )

(Gaudet et al., 2011)

meiotic DNA double-strand break processing

inferred from biological aspect of ancestor with PANTHER:PTN000091177

(assigned by GO_Central )

(Gaudet et al., 2011)

reciprocal meiotic recombination

traceable author statement

(McKim et al., 2000, Shulman et al., 2000)

inferred from biological aspect of ancestor with PANTHER:PTN000091177

(assigned by GO_Central )

(Gaudet et al., 2011)

Cellular Component (1 term)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

nuclear chromosome

inferred from biological aspect of ancestor with PANTHER:PTN000091177

(assigned by GO_Central )

(Gaudet et al., 2011)

Expression Data

Transcript Expression

northern blot

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage -- P-stage

organism

(McKim and Hayashi-Hagihara, 1998)

adult stage | female

(McKim and Hayashi-Hagihara, 1998)

germarium region 2

(McKim and Hayashi-Hagihara, 1998)

germarium region 3

(McKim and Hayashi-Hagihara, 1998)

adult stage | male

testis

(McKim and Hayashi-Hagihara, 1998)

Additional Descriptive Data

mei-W68 transcripts are detected in embryos, larvae, pupae, and adult females on northern blots. They are detected weakly in male testis. Transcripts are detected by in situ hybridization in germarium regions 2 and 3.

(McKim and Hayashi-Hagihara, 1998)

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\mei-W68 in GBrowse 2

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\mei-W68

View exonic expression by tissue for Dmel\mei-W68

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

FLIGHT - Cell culture data for RNAi and other high-throughput technologies

FBgn0002716

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

CG30132-RA

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG30132

Flygut - An atlas of the Drosophila adult midgut

FBgn0002716

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs and Phenotypes

Classical and Insertion Alleles ( 17 )

For All Classical and Insertion Alleles Show

Allele of mei-W68

Class

Mutagen

Associated Insertion

Stocks

Known lesion

mei-W68¹

spontaneous

?{}mei-W68¹

Yes

mei-W68^k05603

hypomorphic allele - genetic evidence

P-element activity

P{lacW}mei-W68^k05603

Yes

mei-W68⁴⁵⁷²

mei-W68^L1

hypomorphic allele - genetic evidence

ethyl methanesulfonate

Yes

mei-W68^unspecified

mei-W68^DG23501

P-element activity

P{wHy}mei-W68^DG23501

Yes

mei-W68^EP899

P-element activity

P{EP}mei-W68^EP899

Yes

mei-W68^EP1144

hypomorphic allele - genetic evidence

P-element activity

P{EP}mei-W68^EP1144

Yes

mei-W68^EY08397

P-element activity

P{EPgy2}mei-W68^EY08397

Yes

mei-W68^W3

P-element activity

P{?EP}mei-W68^W3

Yes

mei-W68^EP-J72.4

P{GSV1}mei-W68^EP-J72.4

Yes

mei-W68^GS10670

P{GSV6}mei-W68^GS10670

Yes

mei-W68^2-0949

mei-W68^k06821b

P-element activity

P{lacW}mei-W68^k06821b

Yes

mei-W68^Z0949

ethyl methanesulfonate

Yes

mei-W68^Z4472

ethyl methanesulfonate

Yes

mei-W68^Z5636

ethyl methanesulfonate

Yes

Other relevant insertions

Transgenic Constructs ( 3 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of mei-W68

Allele of mei-W68

Mutagen

Associated Transgenic Construct

Stocks

Transgenic constructs containing regulatory region of mei-W68

Deletions and Duplications ( 8 )

Disrupted in

Df(2R)LD3

(McKim and Hayashi-Hagihara, 1998)

Df(2R)LL4

(McKim and Hayashi-Hagihara, 1998)

Df(2R)LL5

(McKim and Hayashi-Hagihara, 1998)

Not disrupted in

Df(2R)017

(McKim and Hayashi-Hagihara, 1998)

Df(2R)AA21

(McKim and Hayashi-Hagihara, 1998)

Df(2R)E3578

(BDGP Project Members, 1994-1999)

Df(2R)P34

(McKim and Hayashi-Hagihara, 1998)

Df(2R)X58-7

(BDGP Project Members, 1994-1999)

Summary of Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

lethal | recessive

viable

mei-W68^k05603

viable, with Scer\GAL4^- :

mei-W68^EP1144

Other Phenotypes

Allele

cell cycle defective

mei-W68¹

meiotic cell cycle defective

meiotic cell cycle defective (with mei-W68¹)

mei-W68^L1

meiotic cell cycle defective (with mei-W68^L1)

meiotic cell cycle defective (with mei-W68^Z4472)

mei-W68^L1

meiotic cell cycle defective | female

mei-W68^2-0949

wild-type, with Scer\GAL4^- :

mei-W68^EP899

Phenotype manifest in

Allele

early recombination nodule

germarium

mei-W68^2-0949

late recombination nodule

mei-W68¹

Orthologs

Downloads

Download All DIOPT Orthologs

Download All OrthoDB Orthologs

Human Orthologs (via DIOPT v7.1)

Homo sapiens (Human) (1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Hsap\SPO11

14 of 15

Yes

Model Organism Orthologs (via DIOPT v7.1)

Mus musculus (laboratory mouse) (1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Mmus\Spo11

14 of 15

Yes

Rattus norvegicus (Norway rat) (1)

Rnor\Spo11

11 of 13

Yes

Xenopus tropicalis (Western clawed frog) (1)

Xtro\spo11

6 of 12

Yes

Danio rerio (Zebrafish) (1)

Drer\spo11

10 of 15

Yes

Caenorhabditis elegans (Nematode, roundworm) (1)

Cele\spo-11

13 of 15

Yes

Arabidopsis thaliana (thale-cress) (3)

Atha\RHL2

9 of 9

Yes

Atha\SPO11-2

7 of 9

Yes

Atha\ATSPO11-1

6 of 9

Yes

Saccharomyces cerevisiae (Brewer's yeast) (1)

Scer\SPO11

11 of 15

Yes

Schizosaccharomyces pombe (Fission yeast) (1)

Spom\rec12

11 of 12

Yes

Orthologs in Drosophila Species (via OrthoDB v9.1) ( EOG09190CEY )

Organism

Common Name

Gene

AAA Syntenic Ortholog

Multiple Dmel Genes in this Orthologous Group

Drosophila melanogaster

fruit fly

Dmel\mei-W68

Drosophila suzukii

Spotted wing Drosophila

Drosophila simulans

Drosophila sechellia

Drosophila sechellia

Drosophila erecta

Drosophila yakuba

Drosophila ananassae

Drosophila pseudoobscura pseudoobscura

Dpse\GA24396

Drosophila persimilis

Dper\GL10528

Drosophila willistoni

Dwil\GK15872

Drosophila virilis

Dvir\GJ20469

Drosophila mojavensis

Dmoj\GI20732

Drosophila grimshawi

Dgri\GH20206

Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG09150CHN )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Musca domestica

House fly

Mdoa\17015079

Mayetiola destructor

Hessian fly

Mdes\Mdes011898

Aedes aegypti

Yellow fever mosquito

Aaeg\AAEL013701

Anopheles darlingi

American malaria mosquito

Adar\ADAC001014

Anopheles gambiae

Malaria mosquito

Agam\AGAP010898

Culex quinquefasciatus

Southern house mosquito

Cqui\CPIJ003179

Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W0G9H )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Bombyx mori

Silkmoth

Bmor\BGIBMGA005968

Danaus plexippus

Monarch butterfly

Dple\DPOGS214250-PA

Heliconius melpomene

Postman butterfly

Hmel\HMEL002506

Apis florea

Little honeybee

Aflo\2342674500

Apis mellifera

Western honey bee

Amel\mei-W68

Bombus impatiens

Common eastern bumble bee

Bimp\BIMP15046

Bombus terrestris

Buff-tailed bumblebee

Bter\15212363

Linepithema humile

Argentine ant

Lhum\LH18634

Megachile rotundata

Alfalfa leafcutting bee

Mrot\MROTU:00289f

Nasonia vitripennis

Parasitic wasp

Nvit\Nasvi2EG023760

Dendroctonus ponderosae

Mountain pine beetle

Dpod\YQE_03063

Tribolium castaneum

Red flour beetle

Tcas\TC013087

Pediculus humanus

Human body louse

Phum\PHUM436850

Rhodnius prolixus

Kissing bug

Rpro\RPRC004962

Cimex lectularius

Bed bug

Clec\CLEC005230

Acyrthosiphon pisum

Pea aphid

Apim\ACYPI24707

Zootermopsis nevadensis

Nevada dampwood termite

Znev\Znev_02527

Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X09ZG )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Strigamia maritima

European centipede

Smar\SMAR009376

Ixodes scapularis

Black-legged tick

Isca\ISCW022447

Tetranychus urticae

Two-spotted spider mite

Turt\tetur26g00180

Daphnia pulex

Water flea

Dpux\DAPPUDRAFT_299643

Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G0IMI )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Spo11

Ciona intestinalis

Vase tunicate

Cint\ENSCING00000004353

Human Disease Model Data

FlyBase Human Disease Model Reports

Alleles Reported to Model Human Disease (Disease Ontology)

Download

Models ( 0 )

Allele

Disease

Evidence

References

Interactions ( 0 )

Allele

Disease

Interaction

References

Comments ( 0 )

Human Orthologs (via DIOPT v7.1)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

Complementation?

Transgene?

SPO11; SPO11, initiator of meiotic double stranded breaks

14 of 15

605114

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

esyN Network Diagram

Interactions Browser

Summary of Genetic Interactions

esyN Network Diagram

esyN Network Key:

Suppression

Enhancement

View in Interactions Browser

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

CycG

suppressible

mei-W68

(Nagel et al., 2012)

jnj

suppressible

mei-W68

(Tran et al., 2016)

mio

suppressible

mei-W68

(Iida and Lilly, 2004)

mus301

suppressible

mei-W68

(Ghabrial and Schupbach, 1999)

okr

suppressible

mei-W68

(Barbosa et al., 2007, Ghabrial and Schupbach, 1999)

suppressible

(Lu et al., 2010)

suppressible

(Barbosa et al., 2007)

spn-A

suppressible

mei-W68

(Barbosa et al., 2007, Staeva-Vieira et al., 2003)

spn-B

suppressible

mei-W68

(Liu et al., 2002, Liu et al., 2000, Ghabrial and Schupbach, 1999)

spn-D

suppressible

mei-W68

(Abdu et al., 2003)

tefu

suppressible

mei-W68

(Joyce et al., 2011)

External Data

Linkouts

BioGRID - A database of protein and genetic interactions.

77703

DroID - A comprehensive database of gene and protein interactions.

FBgn0002716

InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.

2768853

Pathways

Gene Group - Pathway Membership (FlyBase)

External Data

Linkouts

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

2-89

Cytogenetic map

56D9-56D9

Sequence location

2R:19,456,170..19,459,523 [+]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

56D9-56D9

Limits computationally determined from genome sequence between P{lacW}l(2)k00705^k00705&P{lacW}mei-W68^k05603 and P{EP}CG11007^EP736

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

56D-56D

(Hayashi-Hagihara, 1998.8.19)

56D8-56D10

(determined by in situ hybridisation)

(Spradling et al., 1999)

58D8-58D10

(determined by in situ hybridisation)

(BDGP Project Members, 1994-1999)

Experimentally Determined Recombination Data

Location

2-89

(FlyBase, 2016)

2-94.7

(Comeron et al., 2012)

2-94

Left of (cM)

(McKim and Hayashi-Hagihara, 1998)

(McKim, 1998.3.10)

Right of (cM)

(McKim, 1998.3.10)

(McKim and Hayashi-Hagihara, 1998)

Notes

Stocks and Reagents

Stocks (9)

Bloomington

4932

y¹/Dp(1;Y)y⁺; mei-W68¹/CyO

43460

w^*; P{GSV1}mei-W68^EP-J72.4 par-1^EP-J72.4

10574

y¹ w^67c23; P{lacW}mei-W68^k05603 par-1^k05603/CyO

Kyoto

107952

y¹/Dp(1;Y)y⁺; mei-W68¹/CyO

108858

y¹ w^67c23; P{lacW}mei-W68^k05603/CyO

202741

y¹ w^67c23; P{GSV6}mei-W68^GS10670/SM1

111182

y^d2 w¹¹¹⁸ P{ey-FLP.N}2 P{GMR-lacZ.C(38.1)}TPN1; P{neoFRT}42D P{lacW}mei-W68^k05603 /CyO y⁺

VDRC

v330154

P{VSH330154}attP40

v101798

P{KK109695}VIE-260B

Genomic Clones (24)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (21)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequences

BDGP DGC clones

RE47050

Other clones

RT05903

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0002716

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0002716

GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents

2768853

Antibody Information

Laboratory Generated Antibodies

Commercially Available Antibodies

Other Information

Relationship to Other Genes

Source for database identify of

Source for identity of: mei-W68 CG7753

(Milshina, 1999.11)

Source for database merge of

Additional comments

One or more of the processed transcripts for this gene share(s) untranslated sequences with a transcript of an adjacent gene, but encode(s) a single open reading frame (ORF). The non-overlapping ORFs that share untranslated sequences are represented by par-1 and mei-W68.

(FlyBase Genome Annotators, 2004)

mei-W68 shares a promoter and 5'-UTR with the N1 class of par-1 transcripts and the coding sequence of mei-W68 falls entirely within the first par-1 intron.

(Shulman et al., 2000)

Other Comments

Intragenic recombination at ry is used as an assay of the effects of mutation on meiotic crossing over.

(McKim et al., 1998)

Origin and Etymology

Discoverer

Etymology

Identification

External Crossreferences and Linkouts ( 32 )

Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

2768853

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information