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Gene Dmel\mei-W68

General Information
Symbol	Dmel\mei-W68	Species	D. melanogaster
Name	meiotic W68	Annotation symbol	CG7753
Feature type	protein_coding_gene	FlyBase ID	FBgn0002716
Gene Model Status	Current	Stock availability	7 publicly available
Also Known As	meiW68
Genomic Location
Chromosome (arm)	2R	Recombination map	2-94
Cytogenetic map	56D9-56D9	Sequence location	2R:15,343,700..15,347,029 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene meiotic W68 is referred to in FlyBase by the symbol Dmel\mei-W68 (CG7753, FBgn0002716). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: DNA topoisomerase (ATP-hydrolyzing) activity. There is experimental evidence that it is involved in the biological process: reciprocal meiotic recombination; oogenesis; early meiotic recombination nodule assembly; late meiotic recombination nodule assembly. 13 alleles are reported. The phenotypes of these alleles are annotated with: early recombination nodule; late recombination nodule. It has one annotated transcript and one annotated polypeptide. Protein features are: DNA topoisomerase VI, subunit A; Spo11/DNA topoisomerase VI, subunit A. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of low expression to a trough of very low expression. Peak expression observed within 06-12 hour embryonic stages. Summary of FlyAtlas Anatomical Expression Data: No expression detected in any larval or adult organs/tissues. Comments on Affy2 ProbeSet: ProbeSet 1634534_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of mei-W68. Gene sequence location is 2R:15343700..15347029.
Phenotypic Description from the Red Book (Lindsley & Zimm 1992)
Gene/Allele symbols may differ from current usage	mei-W68 (R.S. Hawley) Females homozygous for mei-w68 show a complete absence of meiotic recombination (Baker, unpublished data). Ultrastructural studies of pachytene reveal an absence of chromosome condensation and little synaptonemal complex (Carpenter, cited in Baker et al., 1976). A less severe allele (mei-w68L1-Lindsley) reduces exchange to approximately 60% of control levels and also alters the distribution of residual exchanges. Analysis of mitotic chromosome behavior (Baker et al., 1978) suggests that the mei-w68+ gene product is also required in mitotic cells.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2012_01	References Takeo et al., 2011, Curr. Biol. 21(21): 1845--1851 Sequence features HFA07649 BKN29695
FB2011_10
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 56D9-56D9   Limits computationally determined from genome sequence between P{lacW}l(2)k00705k00705&P{lacW}mei-W68k05603 and P{EP}CG11007EP736
Experimentally Determined Cytological Location
Cytogenetic map Notes References 56D-56D     (Hayashi-Hagihara, 1998.8.19) 56D8-56D10   (determined by in situ hybridisation)   (Spradling et al., 1999) 58D8-58D10   (determined by in situ hybridisation)   (BDGP Project Members, 1994-1999)
Experimentally Determined Recombination Data
Location	2-94
Left of (cM)	P{PZ}sm05338 P{PZ}emm1 P{lacW}par-1k06323 (McKim and Hayashi-Hagihara, 1998) sm emm par-1 (McKim, 1998.3.10)
Right of (cM)	RpL11 l(2)k00705 l(2)k09810 hts (McKim, 1998.3.10) P{lacW}l(2)k00705k00705 P{lacW}RpL11k16914 P{PZ}hts01103 P{PZ}l(2)0202902029 (McKim and Hayashi-Hagihara, 1998)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\mei-W68 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) mei-W68-RA FBtr0086461  NM_206179   2276   331
Additional Transcript Data & Comments
Reported size (kB)	2.4, 2.3, 2.1 (northern blot) (McKim and Hayashi-Hagihara, 1998)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein mei-W68-PA   FBpp0085657   37.1   331   7.18     NP_995901   AAF57553
Additional Polypeptide Data & Comments
Reported size (kDa)	331 (aa) (McKim and Hayashi-Hagihara, 1998)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Spo11/DNA topoisomerase VI, subunit A (IPR002815) DNA topoisomerase VI, subunit A (IPR004085)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA391205   AA540697   AA802712   AA948932   AE013599 AAF57553   AC004299   AF085276 AAC61735   AQ025035   AQ025763   AQ254816   BI240378   BI362483   BI373248   BT032934   BT120379   EC064182   GH942816   GH943548   GH945998   GH946047   GH947133   GH947555   GH950699   GH964200   GH967146   GH970366   GH976200   GH977490   GH983237
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q7KPA5
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
northern blot Stage Tissue/Position (including subcellular localization) Reference embryonic stage -- P-stage   organism   (McKim and Hayashi-Hagihara, 1998) adult stage | female     (McKim and Hayashi-Hagihara, 1998) germarium region 2   (McKim and Hayashi-Hagihara, 1998) germarium region 3   (McKim and Hayashi-Hagihara, 1998) adult stage | male   testis   (McKim and Hayashi-Hagihara, 1998)
Additional Descriptive Data
	mei-W68 transcripts are detected in embryos, larvae, pupae, and adult females on northern blots. They are detected weakly in male testis. Transcripts are detected by in situ hybridization in germarium regions 2 and 3. (McKim and Hayashi-Hagihara, 1998)
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0002716    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0002716 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of low expression to a trough of very low expression. Peak expression observed within 06-12 hour embryonic stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0002716 expression level Developmental Stage   Expression Level embryo 00-02hr    75 embryo 02-04hr    32 embryo 04-06hr    62 embryo 06-08hr    140 embryo 08-10hr    90 embryo 10-12hr    63 embryo 12-14hr    54 embryo 14-16hr    61 embryo 16-18hr    50 embryo 18-20hr    30 embryo 20-22hr    25 embryo 22-24hr    33 larva L1    40 larva L2    20 larva L3 12hr old    16 larva L3 puffstage 1-2    23 larva L3 puffstage 3-6    52 larva L3 puffstage 7-9    96 white prepupae new    98 white prepupae 12hr    81 white prepupae 24hr    62 pupae 2d postWPP    51 pupae 3d postWPP    40 pupae 4d postWPP    30 adult male 01day    50 adult male 05day    48 adult male 30day    60 adult female 01day    51 adult female 05day    59 adult female 30day    66 Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr    75 embryo 02-04hr    32 embryo 04-06hr    62 embryo 06-08hr  (140) embryo 08-10hr    90 embryo 10-12hr    63 embryo 12-14hr    54 embryo 14-16hr    61 embryo 16-18hr    50 embryo 18-20hr    30 embryo 20-22hr    25 embryo 22-24hr    33 larva L1    40 larva L2    20 larva L3 12hr old    16 larva L3 puffstage 1-2    23 larva L3 puffstage 3-6    52 larva L3 puffstage 7-9    96 white prepupae new    98 white prepupae 12hr    81 white prepupae 24hr    62 pupae 2d postWPP    51 pupae 3d postWPP    40 pupae 4d postWPP    30 adult male 01day    50 adult male 05day    48 adult male 30day    60 adult female 01day    51 adult female 05day    59 adult female 30day    66 Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    75 embryo 02-04hr    32 embryo 04-06hr    62 embryo 06-08hr    140 embryo 08-10hr    90 embryo 10-12hr    63 embryo 12-14hr    54 embryo 14-16hr    61 embryo 16-18hr    50 embryo 18-20hr    30 embryo 20-22hr    25 embryo 22-24hr    33 larva L1    40 larva L2    20 larva L3 12hr old    16 larva L3 puffstage 1-2    23 larva L3 puffstage 3-6    52 larva L3 puffstage 7-9    96 white prepupae new    98 white prepupae 12hr    81 white prepupae 24hr    62 pupae 2d postWPP    51 pupae 3d postWPP    40 pupae 4d postWPP    30 adult male 01day    50 adult male 05day    48 adult male 30day    60 adult female 01day    51 adult female 05day    59 adult female 30day    66 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    75 embryo 02-04hr    32 embryo 04-06hr    62 embryo 06-08hr    140 embryo 08-10hr    90 embryo 10-12hr    63 embryo 12-14hr    54 embryo 14-16hr    61 embryo 16-18hr    50 embryo 18-20hr    30 embryo 20-22hr    25 embryo 22-24hr    33 larva L1    40 larva L2    20 larva L3 12hr old    16 larva L3 puffstage 1-2    23 larva L3 puffstage 3-6    52 larva L3 puffstage 7-9    96 white prepupae new    98 white prepupae 12hr    81 white prepupae 24hr    62 pupae 2d postWPP    51 pupae 3d postWPP    40 pupae 4d postWPP    30 adult male 01day    50 adult male 05day    48 adult male 30day    60 adult female 01day    51 adult female 05day    59 adult female 30day    66 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    75 embryo 02-04hr    32 embryo 04-06hr    62 embryo 06-08hr    140 embryo 08-10hr    90 embryo 10-12hr    63 embryo 12-14hr    54 embryo 14-16hr    61 embryo 16-18hr    50 embryo 18-20hr    30 embryo 20-22hr    25 embryo 22-24hr    33 larva L1    40 larva L2    20 larva L3 12hr old    16 larva L3 puffstage 1-2    23 larva L3 puffstage 3-6    52 larva L3 puffstage 7-9    96 white prepupae new    98 white prepupae 12hr    81 white prepupae 24hr    62 pupae 2d postWPP    51 pupae 3d postWPP    40 pupae 4d postWPP    30 adult male 01day    50 adult male 05day    48 adult male 30day    60 adult female 01day    51 adult female 05day    59 adult female 30day    66 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0002716 expression level Developmental Stage   Expression Level embryo 00-02hr    75 embryo 02-04hr    32 embryo 04-06hr    62 embryo 06-08hr    140 embryo 08-10hr    90 embryo 10-12hr    63 embryo 12-14hr    54 embryo 14-16hr    61 embryo 16-18hr    50 embryo 18-20hr    30 embryo 20-22hr    25 embryo 22-24hr    33 larva L1    40 larva L2    20 larva L3 12hr old    16 larva L3 puffstage 1-2    23 larva L3 puffstage 3-6    52 larva L3 puffstage 7-9    96 white prepupae new    98 white prepupae 12hr    81 white prepupae 24hr    62 pupae 2d postWPP    51 pupae 3d postWPP    40 pupae 4d postWPP    30 adult male 01day    50 adult male 05day    48 adult male 30day    60 adult female 01day    51 adult female 05day    59 adult female 30day    66 Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr    75 embryo 02-04hr    32 embryo 04-06hr    62 embryo 06-08hr  140 embryo 08-10hr    90 embryo 10-12hr    63 embryo 12-14hr    54 embryo 14-16hr    61 embryo 16-18hr    50 embryo 18-20hr    30 embryo 20-22hr    25 embryo 22-24hr    33 larva L1    40 larva L2    20 larva L3 12hr old    16 larva L3 puffstage 1-2    23 larva L3 puffstage 3-6    52 larva L3 puffstage 7-9    96 white prepupae new    98 white prepupae 12hr    81 white prepupae 24hr    62 pupae 2d postWPP    51 pupae 3d postWPP    40 pupae 4d postWPP    30 adult male 01day    50 adult male 05day    48 adult male 30day    60 adult female 01day    51 adult female 05day    59 adult female 30day    66 Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    75 embryo 02-04hr    32 embryo 04-06hr    62 embryo 06-08hr    140 embryo 08-10hr    90 embryo 10-12hr    63 embryo 12-14hr    54 embryo 14-16hr    61 embryo 16-18hr    50 embryo 18-20hr    30 embryo 20-22hr    25 embryo 22-24hr    33 larva L1    40 larva L2    20 larva L3 12hr old    16 larva L3 puffstage 1-2    23 larva L3 puffstage 3-6    52 larva L3 puffstage 7-9    96 white prepupae new    98 white prepupae 12hr    81 white prepupae 24hr    62 pupae 2d postWPP    51 pupae 3d postWPP    40 pupae 4d postWPP    30 adult male 01day    50 adult male 05day    48 adult male 30day    60 adult female 01day    51 adult female 05day    59 adult female 30day    66 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    75 embryo 02-04hr    32 embryo 04-06hr    62 embryo 06-08hr    140 embryo 08-10hr    90 embryo 10-12hr    63 embryo 12-14hr    54 embryo 14-16hr    61 embryo 16-18hr    50 embryo 18-20hr    30 embryo 20-22hr    25 embryo 22-24hr    33 larva L1    40 larva L2    20 larva L3 12hr old    16 larva L3 puffstage 1-2    23 larva L3 puffstage 3-6    52 larva L3 puffstage 7-9    96 white prepupae new    98 white prepupae 12hr    81 white prepupae 24hr    62 pupae 2d postWPP    51 pupae 3d postWPP    40 pupae 4d postWPP    30 adult male 01day    50 adult male 05day    48 adult male 30day    60 adult female 01day    51 adult female 05day    59 adult female 30day    66 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    75 embryo 02-04hr    32 embryo 04-06hr    62 embryo 06-08hr    140 embryo 08-10hr    90 embryo 10-12hr    63 embryo 12-14hr    54 embryo 14-16hr    61 embryo 16-18hr    50 embryo 18-20hr    30 embryo 20-22hr    25 embryo 22-24hr    33 larva L1    40 larva L2    20 larva L3 12hr old    16 larva L3 puffstage 1-2    23 larva L3 puffstage 3-6    52 larva L3 puffstage 7-9    96 white prepupae new    98 white prepupae 12hr    81 white prepupae 24hr    62 pupae 2d postWPP    51 pupae 3d postWPP    40 pupae 4d postWPP    30 adult male 01day    50 adult male 05day    48 adult male 30day    60 adult female 01day    51 adult female 05day    59 adult female 30day    66 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0002716    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0002716 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: No expression detected in any larval or adult organs/tissues. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0002716 expression level Tissue   Expression Level Larval Central Nervous System    3 Larval Midgut    8.1 Larval Hindgut    1.8 Larval Malpighian Tubules    5.3 Larval Fat Body    8.4 Larval Salivary Gland    2.2 Larval Trachea    0.475 Larval Carcass    2.55 Adult Head    2.8 Adult Eye    3.975 Adult Brain    4.1 Adult Thoracic-Abdominal Ganglion    3.2 Adult Crop    5.7 Adult Midgut    5.3 Adult Hindgut    2.5 Adult Malpighian Tubules    4.9 Adult Fat Body    6.7 Adult Salivary Gland    5 Adult Heart    1.325 Adult VirginFemale Spermatheca    6.7 Adult InseminatedFemale Spermatheca    3.9 Adult Ovary    7.8 Adult Testis    7.6 Adult Male Accessory Gland    6.1 Adult Carcass    4.9 Expression Level Scale  None   Low  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    3 Larval Midgut    8.1 Larval Hindgut    1.8 Larval Malpighian Tubules    5.3 Larval Fat Body    8.4 Larval Salivary Gland    2.2 Larval Trachea    0.475 Larval Carcass    2.55 Adult Head    2.8 Adult Eye    3.975 Adult Brain    4.1 Adult Thoracic-Abdominal Ganglion    3.2 Adult Crop    5.7 Adult Midgut    5.3 Adult Hindgut    2.5 Adult Malpighian Tubules    4.9 Adult Fat Body    6.7 Adult Salivary Gland    5 Adult Heart    1.325 Adult VirginFemale Spermatheca    6.7 Adult InseminatedFemale Spermatheca    3.9 Adult Ovary    7.8 Adult Testis    7.6 Adult Male Accessory Gland    6.1 Adult Carcass    4.9 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    3 Larval Midgut    8.1 Larval Hindgut    1.8 Larval Malpighian Tubules    5.3 Larval Fat Body    8.4 Larval Salivary Gland    2.2 Larval Trachea    0.475 Larval Carcass    2.55 Adult Head    2.8 Adult Eye    3.975 Adult Brain    4.1 Adult Thoracic-Abdominal Ganglion    3.2 Adult Crop    5.7 Adult Midgut    5.3 Adult Hindgut    2.5 Adult Malpighian Tubules    4.9 Adult Fat Body    6.7 Adult Salivary Gland    5 Adult Heart    1.325 Adult VirginFemale Spermatheca    6.7 Adult InseminatedFemale Spermatheca    3.9 Adult Ovary    7.8 Adult Testis    7.6 Adult Male Accessory Gland    6.1 Adult Carcass    4.9 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    3 Larval Midgut    8.1 Larval Hindgut    1.8 Larval Malpighian Tubules    5.3 Larval Fat Body    8.4 Larval Salivary Gland    2.2 Larval Trachea    0.475 Larval Carcass    2.55 Adult Head    2.8 Adult Eye    3.975 Adult Brain    4.1 Adult Thoracic-Abdominal Ganglion    3.2 Adult Crop    5.7 Adult Midgut    5.3 Adult Hindgut    2.5 Adult Malpighian Tubules    4.9 Adult Fat Body    6.7 Adult Salivary Gland    5 Adult Heart    1.325 Adult VirginFemale Spermatheca    6.7 Adult InseminatedFemale Spermatheca    3.9 Adult Ovary    7.8 Adult Testis    7.6 Adult Male Accessory Gland    6.1 Adult Carcass    4.9 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0002716 expression level Tissue   Expression Level Larval Central Nervous System    3 Larval Midgut    8.1 Larval Hindgut    1.8 Larval Malpighian Tubules    5.3 Larval Fat Body    8.4 Larval Salivary Gland    2.2 Larval Trachea    0.475 Larval Carcass    2.55 Adult Head    2.8 Adult Eye    3.975 Adult Brain    4.1 Adult Thoracic-Abdominal Ganglion    3.2 Adult Crop    5.7 Adult Midgut    5.3 Adult Hindgut    2.5 Adult Malpighian Tubules    4.9 Adult Fat Body    6.7 Adult Salivary Gland    5 Adult Heart    1.325 Adult VirginFemale Spermatheca    6.7 Adult InseminatedFemale Spermatheca    3.9 Adult Ovary    7.8 Adult Testis    7.6 Adult Male Accessory Gland    6.1 Adult Carcass    4.9 Expression Level Scale  None   Low  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    3 Larval Midgut    8.1 Larval Hindgut    1.8 Larval Malpighian Tubules    5.3 Larval Fat Body    8.4 Larval Salivary Gland    2.2 Larval Trachea    0.475 Larval Carcass    2.55 Adult Head    2.8 Adult Eye    3.975 Adult Brain    4.1 Adult Thoracic-Abdominal Ganglion    3.2 Adult Crop    5.7 Adult Midgut    5.3 Adult Hindgut    2.5 Adult Malpighian Tubules    4.9 Adult Fat Body    6.7 Adult Salivary Gland    5 Adult Heart    1.325 Adult VirginFemale Spermatheca    6.7 Adult InseminatedFemale Spermatheca    3.9 Adult Ovary    7.8 Adult Testis    7.6 Adult Male Accessory Gland    6.1 Adult Carcass    4.9 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    3 Larval Midgut    8.1 Larval Hindgut    1.8 Larval Malpighian Tubules    5.3 Larval Fat Body    8.4 Larval Salivary Gland    2.2 Larval Trachea    0.475 Larval Carcass    2.55 Adult Head    2.8 Adult Eye    3.975 Adult Brain    4.1 Adult Thoracic-Abdominal Ganglion    3.2 Adult Crop    5.7 Adult Midgut    5.3 Adult Hindgut    2.5 Adult Malpighian Tubules    4.9 Adult Fat Body    6.7 Adult Salivary Gland    5 Adult Heart    1.325 Adult VirginFemale Spermatheca    6.7 Adult InseminatedFemale Spermatheca    3.9 Adult Ovary    7.8 Adult Testis    7.6 Adult Male Accessory Gland    6.1 Adult Carcass    4.9 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    3 Larval Midgut    8.1 Larval Hindgut    1.8 Larval Malpighian Tubules    5.3 Larval Fat Body    8.4 Larval Salivary Gland    2.2 Larval Trachea    0.475 Larval Carcass    2.55 Adult Head    2.8 Adult Eye    3.975 Adult Brain    4.1 Adult Thoracic-Abdominal Ganglion    3.2 Adult Crop    5.7 Adult Midgut    5.3 Adult Hindgut    2.5 Adult Malpighian Tubules    4.9 Adult Fat Body    6.7 Adult Salivary Gland    5 Adult Heart    1.325 Adult VirginFemale Spermatheca    6.7 Adult InseminatedFemale Spermatheca    3.9 Adult Ovary    7.8 Adult Testis    7.6 Adult Male Accessory Gland    6.1 Adult Carcass    4.9 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    2.8   NA  Eye    3.975   NA  Brain    4.1   3  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    3.2   NA  Crop    5.7   8.1  Midgut    5.3   1.8  Hindgut    2.5   5.3  Malpighian Tubules    4.9   8.4  Fat Body    6.7   2.2  Salivary Gland    5   NA  Heart    1.325   0.475  Trachea    NA   NA  VirginFemale Spermatheca    6.7   NA  InseminatedFemale Spermatheca    3.9   NA  Ovary    7.8   NA  Testis    7.6   NA  Male Accessory Gland    6.1   2.55  Carcass    4.9 modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0002716 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG30132-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal | recessive mei-W68k05603 mei-W68W3 viable mei-W68k05603 viable, with Scer\GAL4[-]: mei-W68EP1144 Other Phenotypes Allele meiotic cell cycle defective mei-W681 mei-W684572 wild-type, with Scer\GAL4[-]: mei-W68EP899 Phenotype manifest in Allele early recombination nodule mei-W681 mei-W68L1 late recombination nodule mei-W681
Classical Alleles ( 11 )
For All Classical Alleles Show
Allele of mei-W68 Class Mutagen Stocks Known lesion mei-W68k05603 hypomorphic allele - genetic evidence P-element activity 3 Yes mei-W681 spontaneous 2 Yes mei-W68DG23501 P-element activity 1 -- mei-W684572 0 -- mei-W68EP1144 hypomorphic allele - genetic evidence P-element activity 0 -- mei-W68EP899 P-element activity 0 Yes mei-W68EY08397 P-element activity 0 Yes mei-W68k06821b P-element activity 0 Yes mei-W68L1 hypomorphic allele - genetic evidence ethyl methanesulfonate 0 -- mei-W68unspecified 0 -- mei-W68W3 P-element activity 0 Yes
Alleles Carried on Transgenic Constructs ( 2 )
For All Alleles Carried on Transgenic Constructs Show
Allele of mei-W68 Class Mutagen Stocks Known lesion mei-W68KK109695 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes mei-W68GD16231 in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(2R)LD3 (McKim and Hayashi-Hagihara, 1998) Df(2R)LL4 (McKim and Hayashi-Hagihara, 1998) Df(2R)LL5 (McKim and Hayashi-Hagihara, 1998)
Not disrupted in	Df(2R)017 (McKim and Hayashi-Hagihara, 1998) Df(2R)AA21 (McKim and Hayashi-Hagihara, 1998) Df(2R)E3578 (BDGP Project Members, 1994-1999) Df(2R)P34 (McKim and Hayashi-Hagihara, 1998) Df(2R)X58-7 (BDGP Project Members, 1994-1999)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD16231} NA P{KK109695} NA
Insertions
	Type of insertions Name Expression data insertion of mobile activating element P{EP}mei-W68EP899 NA P{EP}mei-W68EP1144 NA P{EPgy2}mei-W68EY08397 NA insertion of enhancer trap P{lacW}mei-W68k05603 No P{lacW}mei-W68k06821b No miscellaneous insertions ?{}mei-W681 NA P{?EP}mei-W68W3 NA P{wHy}mei-W68DG23501 NA
Gene Ontology: Function, Process & Cellular Component ( 9 unique terms )
Terms Based on Experimental Evidence ( 4 terms )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
early meiotic recombination nodule assembly inferred from mutant phenotype (Carpenter, 2003) late meiotic recombination nodule assembly inferred from mutant phenotype (Carpenter, 2003) oogenesis inferred from genetic interaction with p53, okr (Lu et al., 2010) reciprocal meiotic recombination inferred from mutant phenotype (McKim et al., 1998)
Cellular Component ( 0 terms)
Terms Based on Predictions or Assertions ( 6 terms )
Molecular Function
CV term Evidence References
ATP binding inferred from electronic annotation with InterPro:IPR002815 (FlyBase Curators et al., 2004-) DNA topoisomerase (ATP-hydrolyzing) activity inferred from sequence or structural similarity with UniProtKB:O05208 (FlyBase, 1992-) non-traceable author statement (Hayashi-Hagihara, 1998.8.19)
Biological Process
CV term Evidence References
DNA topological change inferred from electronic annotation with InterPro:IPR004085 (FlyBase Curators et al., 2004-) meiotic DNA double-strand break formation non-traceable author statement (Liu and McKim, 2000) reciprocal meiotic recombination traceable author statement (Shulman et al., 2000, McKim et al., 2000)
Cellular Component
CV term Evidence References
chromosome inferred from electronic annotation with InterPro:IPR002815, InterPro:IPR004085 (FlyBase Curators et al., 2004-)
Sequence Ontology: Class of Gene
	gene_with_dicistronic_primary_transcript (FlyBase Genome Annotators, 2004) nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions mei-W68 allele Gene References mei-W681 spn-B (Liu et al., 2000, Liu et al., 2002) mei-W68unspecified mus301 (Ghabrial and Schupbach, 1999) okr (Ghabrial and Schupbach, 1999) spn-B (Ghabrial and Schupbach, 1999) spn-D (Abdu et al., 2003) unspecified mei-41 (Ghabrial and Schupbach, 1999) spn-A (Staeva-Vieira et al., 2003)
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 77703 DroID - A comprehensive database of gene and protein interactions. • FBgn0002716 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 2768853
Orthologs
Genome-wide drosophilid orthologs	Dana\GF11715 Dere\GG21975 Dgri\GH20206 Dmoj\GI20732 Dper\GL10528 Dpse\GA24396 Dsec\GM21963 Dsim\GD11457 Dvir\GJ20469 Dwil\GK15872 Dyak\GE12053
Curated drosophilid orthologs	Dsim\mei-W68 (Anderson et al., 2009)
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AGAP010898-PA Anopheles gambiae (mosquito) XP_001122679.1 Apis mellifera (honey bee) At5g02820.1 Arabidopsis thaliana (wall cress) 26068 Batrachochytrium dendrobatidis (chytrid fungus) XP_001897772.1 Brugia malayi (roundworm nematode) BGIBMGA005968-PA Bombyx mori (silk worm) CAL0006003 Candida albicans (a form of yeast) CBP28830 Caenorhabditis briggsae (nematode) CE06363 Caenorhabditis elegans (worm) ENSCAFP00000017712 Canis familiaris (dog) CAGL0C02783g Candida glabrata (haploid yeast) Chro.80160 Cryptosporidium hominis (obligate parasite) ENSCINP00000009041 Ciona intestinalis (sea squirt) JA16844 Caenorhabditis japonica (nematode) CMQ111C Cyanidioschyzon merolae (red alga) cgd3_2720 Cryptosporidium parvum (protozoan parasite) CPIJ003179 Culex pipens (mosquito) ENSCPOP00000010503 Cavia porcellus (guinea pig) 76283 Chlamidomonas reinhardtii (green alga) RP47710 Caenorhabditis remanei (nematode) RP49155 Caenorhabditis remanei (nematode) ENSCSAVP00000017752 Ciona savignyi (sedentary tunicate) 89794 Capitella spl (polychaete worm) DEHA2B13112g Debaryomyces Hansenii (yeast) 299643 Daphnia pulex (daphnia) ENSDARP00000002837 Danio rerio (zebra fish) ENSECAP00000010940 Equus caballus (horse) XP_653750 Entamoeba histolytica (anaerobic protozoan) ENSGACP00000019961 Gymnopilus aculeatus (mushroom) ENSGALP00000012397 Gallus gallus (chicken) GL50803_15279 Giardia lamblia (flagellated protozoan) 83227 Hypsipyla robusta (cedar shoot borer) ENSP00000360304 Homo sapiens (human) ISCW022447-PA Ixodes scapularis (deer tick) 199608 Lottia gigantea (owl limpet) LmjF16.0630 Leishmania major (virus) 37903 Monocosta brevicollis (choanoflagellate) ENSMODP00000029142 Monodelphis domestica (gray opossum) ENSMMUP00000000345 Macaca mulatta (rhesus monkey) ENSMUSP00000059056 Mus musculus (house mouse) 203170 Nematostella vectensis (starlet anemone) XP_001599577.1 Nasonia vitripennis (wasp) ENSOANP00000014733 Ornithorynchus anatinus (platypus) ENSORLP00000014612 Oryzias latipes (japanese killifish) LOC_Os03g54091.1 Oryza sativa (asian rice) 32686 Ostreococcus tauri (green alga) PF10_0412 Plasmodium falciparum (protozoal parasite) PHUM009689-PA Pediculus humanus (human body louse) 126981 Physcomitrella patens (moss) ENSPPYP00000012466 Pongo pygmaeus (orangutan) 158593 Phytophthora sojae (root rot pathogen) 675953 Populus trichocarpa (black cottonwood) ENSPTRP00000052015 Pan troglodytes (chimpanzee) PVX_111340 Plasmodium vivax (protozoal parasite) ENSRNOP00000008959 Rattus norvegicus (norway rat) 4996665 Sorghum bicolor (sorghum) YHL022C Saccharomyces cerevisiae (budding yeast) SPAC17A5.11 Schizosaccharomyces pombe (fission yeast) XP_001202309.1 Strongylocentrotus purpuratus (purple sea urchin) TA19505 Theileria annulata (apicomplexan parasite) XP_001815524.1 Tribolium castaneum (red flour beetle) Tc00.1047053509537.60 Trypanosoma cruzi (parasitic trypanosome) ENSTNIP00000015587 Tetraodon nigroviridis (green spotted pufferfish) 42646 Thalassiosira pseudonana (marine diatom) ENSTRUP00000010904 Takifugu rubripes (pufferfish Takifugu) 88860.m00049 Trichomonas vaginalis (parasitic flagellated protozoan) YALI0F16335g Yarrowia lipolytica (nonconventional yeast) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB13439 NV18475 LH18634 ISCW022447 FBgn0229826 FBgn0217875 FBgn0207609 FBgn0183206 FBgn0176840 FBgn0168222 JGI_V11_299643 FBgn0245793 FBgn0148138 FBgn0143467 FBgn0127670 FBgn0114153 FBgn0088755 CPIJ003179 BGIBMGA005968 ACYPI24707 GB13628 AGAP010898 AAEL013701 PHUM436850 GLEAN_13087
Stocks & Reagents
Stocks Listed in FlyBase ( 7 )
Bloomington	4932 y1/Dp(1;Y)y+; mei-W681/CyO 20467 y1 w67c23; P{wHy}mei-W68DG23501 par-1DG23501 10574 y1 w67c23; P{lacW}mei-W68k05603 par-1k05603/CyO
Kyoto	107952 y1/Dp(1;Y)y+; mei-W681/CyO 108858 y1 w67c23; P{lacW}mei-W68k05603/CyO 111182 yd2 w1118 P{ey-FLP.N}2 P{GMR-lacZ.C(38.1)}TPN1; P{neoFRT}42D P{lacW}mei-W68k05603 /CyO y+
VDRC	v101798 P{KK109695}VIE-260B
Genomic Clones ( 1 )
	BACR25K02 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 21 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones
Other clones	IP20426 RT05903
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	GM06191 LD10429 LD27632 RE37214 RE60494
Other clones	79349 RP004168768 RP004207326 RP004212549 RP004212951 RP004223303 RP004225216 RP004249399 RP004254438 RP004289828 RP004324993 RP004428338 RP004470698 RP004506987
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0002716 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 2768853
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: mei-W68 CG7753 (Milshina, 1999.11)
Source for database merge of
Additional comments	One or more of the processed transcripts for this gene share(s) untranslated sequences with a transcript of an adjacent gene, but encode(s) a single open reading frame (ORF). The non-overlapping ORFs that share untranslated sequences are represented by par-1 and mei-W68. (FlyBase Genome Annotators, 2004) mei-W68 shares a promoter and 5'-UTR with the N1 class of par-1 transcripts and the coding sequence of mei-W68 falls entirely within the first par-1 intron. (Shulman et al., 2000)
Other Comments
	Intragenic recombination at ry is used as an assay of the effects of mutation on meiotic crossing over. (McKim et al., 1998)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_206179 RefSeq (Proteins) • NP_995901 DDBJ / EMBL / GenBank • AA540697 AAC61735 AAF57553 AC004299 AF085276 AQ025035 AQ025763 AQ254816 BI362483 Entrez Gene - A searchable database of RefSeq genes. • 2768853 UniProtKB/TrEMBL • Q7KPA5
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Spo11/DNA topoisomerase VI, subunit A (IPR002815) DNA topoisomerase VI, subunit A (IPR004085)
Linkouts
	BioGRID - A database of protein and genetic interactions • 77703 DroID - A comprehensive database of gene and protein interactions. • FBgn0002716 DRSC - Results from RNAi screens. • FBgn0002716 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0002716 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG30132-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0002716 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 2768853 InParanoid A subset of ortholog calls from InParanoid. • AGAP010898-PA Anopheles gambiae (mosquito) XP_001122679.1 Apis mellifera (honey bee) At5g02820.1 Arabidopsis thaliana (wall cress) 26068 Batrachochytrium dendrobatidis (chytrid fungus) XP_001897772.1 Brugia malayi (roundworm nematode) BGIBMGA005968-PA Bombyx mori (silk worm) CAL0006003 Candida albicans (a form of yeast) CBP28830 Caenorhabditis briggsae (nematode) CE06363 Caenorhabditis elegans (worm) ENSCAFP00000017712 Canis familiaris (dog) CAGL0C02783g Candida glabrata (haploid yeast) Chro.80160 Cryptosporidium hominis (obligate parasite) ENSCINP00000009041 Ciona intestinalis (sea squirt) JA16844 Caenorhabditis japonica (nematode) CMQ111C Cyanidioschyzon merolae (red alga) cgd3_2720 Cryptosporidium parvum (protozoan parasite) CPIJ003179 Culex pipens (mosquito) ENSCPOP00000010503 Cavia porcellus (guinea pig) 76283 Chlamidomonas reinhardtii (green alga) RP47710 Caenorhabditis remanei (nematode) RP49155 Caenorhabditis remanei (nematode) ENSCSAVP00000017752 Ciona savignyi (sedentary tunicate) 89794 Capitella spl (polychaete worm) DEHA2B13112g Debaryomyces Hansenii (yeast) 299643 Daphnia pulex (daphnia) ENSDARP00000002837 Danio rerio (zebra fish) ENSECAP00000010940 Equus caballus (horse) XP_653750 Entamoeba histolytica (anaerobic protozoan) ENSGACP00000019961 Gymnopilus aculeatus (mushroom) ENSGALP00000012397 Gallus gallus (chicken) GL50803_15279 Giardia lamblia (flagellated protozoan) 83227 Hypsipyla robusta (cedar shoot borer) ENSP00000360304 Homo sapiens (human) ISCW022447-PA Ixodes scapularis (deer tick) 199608 Lottia gigantea (owl limpet) LmjF16.0630 Leishmania major (virus) 37903 Monocosta brevicollis (choanoflagellate) ENSMODP00000029142 Monodelphis domestica (gray opossum) ENSMMUP00000000345 Macaca mulatta (rhesus monkey) ENSMUSP00000059056 Mus musculus (house mouse) 203170 Nematostella vectensis (starlet anemone) XP_001599577.1 Nasonia vitripennis (wasp) ENSOANP00000014733 Ornithorynchus anatinus (platypus) ENSORLP00000014612 Oryzias latipes (japanese killifish) LOC_Os03g54091.1 Oryza sativa (asian rice) 32686 Ostreococcus tauri (green alga) PF10_0412 Plasmodium falciparum (protozoal parasite) PHUM009689-PA Pediculus humanus (human body louse) 126981 Physcomitrella patens (moss) ENSPPYP00000012466 Pongo pygmaeus (orangutan) 158593 Phytophthora sojae (root rot pathogen) 675953 Populus trichocarpa (black cottonwood) ENSPTRP00000052015 Pan troglodytes (chimpanzee) PVX_111340 Plasmodium vivax (protozoal parasite) ENSRNOP00000008959 Rattus norvegicus (norway rat) 4996665 Sorghum bicolor (sorghum) YHL022C Saccharomyces cerevisiae (budding yeast) SPAC17A5.11 Schizosaccharomyces pombe (fission yeast) XP_001202309.1 Strongylocentrotus purpuratus (purple sea urchin) TA19505 Theileria annulata (apicomplexan parasite) XP_001815524.1 Tribolium castaneum (red flour beetle) Tc00.1047053509537.60 Trypanosoma cruzi (parasitic trypanosome) ENSTNIP00000015587 Tetraodon nigroviridis (green spotted pufferfish) 42646 Thalassiosira pseudonana (marine diatom) ENSTRUP00000010904 Takifugu rubripes (pufferfish Takifugu) 88860.m00049 Trichomonas vaginalis (parasitic flagellated protozoan) YALI0F16335g Yarrowia lipolytica (nonconventional yeast) InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 2768853 modMine - Data generated by the modENCODE project. • FBgn0002716 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB13439 NV18475 LH18634 ISCW022447 FBgn0229826 FBgn0217875 FBgn0207609 FBgn0183206 FBgn0176840 FBgn0168222 JGI_V11_299643 FBgn0245793 FBgn0148138 FBgn0143467 FBgn0127670 FBgn0114153 FBgn0088755 CPIJ003179 BGIBMGA005968 ACYPI24707 GB13628 AGAP010898 AAEL013701 PHUM436850 GLEAN_13087
Synonyms & Secondary IDs ( 11 )
Reported As
Symbol Synonym	CG7753 (Keleman et al., 2009.8.5) CG30132   l(2)k05603 (Palmer et al., 1999, ) meiW68 (Huynh and St. Johnston, 2004) mei W-68 (Santos, 1999) mei-W68 (McCaffrey et al., 2006, McKim et al., 2000, Klattenhoff et al., 2007, Garcia et al., 2007, Barbosa et al., 2007, Mehrotra and McKim, 2006, Jang et al., 2003, Joyce and McKim, 2009, Anderson et al., 2009, Wu et al., 2008, Peng and Karpen, 2009, Bozas et al., 2009, Peretz et al., 2009, Meyer et al., 2010, Lu et al., 2010, Klattenhoff et al., 2009) Mei-W68 (Hochwagen, 2006) MeiW68 (Reis et al., 2011) spo11 (Lu et al., 2010) W68 (McKee et al., 2000)
Name Synonym	meiotic W68
Secondary FlyBase IDs
	FBgn0022167 FBgn0050132 FBgn0065111
References ( 88 )
Generate a list of	All references relating to this gene ( 88 )
List References by type	Research paper  ( 40 ) Supplementary material  ( 2 ) Review  ( 13 ) Personal communication to FlyBase  ( 7 ) Abstract  ( 12 ) FlyBase analysis  ( 4 ) Conference report  ( 2 ) Curated genome annotation  ( 2 ) DNA/RNA sequence record  ( 1 ) Computer file  ( 3 ) Automatic genome annotation  ( 1 ) Letter  ( 1 )
Recent research papers ( 4 )
	Reis et al., 2011, PLoS ONE 6(3): e17512 Drosophila Genes That Affect Meiosis Duration Are among the Meiosis Related Genes That Are More Often Found Duplicated. [FBrf0213266] Takeo et al., 2011, Curr. Biol. 21(21): 1845--1851 Synaptonemal complex-dependent centromeric clustering and the initiation of synapsis in Drosophila oocytes. [FBrf0216635] Lu et al., 2010, Science 328(5983): 1278--1281 Meiotic recombination provokes functional activation of the p53 regulatory network. [FBrf0210965] Meyer et al., 2010, BMC Genet. 11(1): 104 A single mutation results in diploid gamete formation and parthenogenesis in a Drosophila yemanuclein-alpha meiosis I defective mutant. [FBrf0212440] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2010 Show reviews ...