• Home
• Tools
  • Tools Overview
  • Query Tools

    
    • QuickSearch
    • QueryBuilder
    • TermLink
    • CytoSearch
    • RNA-Seq Search
    • Interactions Browser
    • ImageBrowse
    • Find A Person
    • Google™ FlyBase
  • Genomic/Map Tools

    
    • BLAST
    • GBrowse
    • GBrowse 2 Beta
    • CytoSearch
    • Feature Mapper
    • Aberrations Maps
    • Chromosome Maps
    • Coordinates Converter
  • Retrieve/Convert

    
    • Batch Download
    • Coordinates Converter
    • ID Converter
  • Data Submission

    
    • Fast-Track Your Paper
    • Submit Personal Comm
    • Add A New Person
    • Update Person Info
  • People

    
    • Find A Person
    • Add A New Person
    • Update Person Info
• Files
  • Files Overview
  • Current release
  • Archived releases
  • Map Conversion
  • FTP site:
  • Releases (FTP)
  • Genomes (FTP)
• Species
  • Phylogeny
  • Sequenced Species
  • Synteny Table
  • Color Illustrations
  • Abbreviations
• Documents
  • About FlyBase
  • Reference Manual:
  • Sections
  • Contents
  • Nomenclature
  • Release Notes
• Resources
  • All Resources
  • Model Organisms
  • Stock Collections
  • Vectors & Constructs
  • Other links:
  • BDGP
  • DGRC
  • DIS by issue
  • FlyExpress
  • Interactive Fly
  • modENCODE
  • Textpresso for Fly
• News
  • News
  • FlyBase Forum
  • FlyBase Positions
  • Meetings
  • Courses
  • Fly Board
  • White papers
  • Funding
  • bionet.dros
• Help
  • Google™ FlyBase
  • Site Map
  • FAQs
  • FlyBase Guides
  • Video Tutorials
  • Report help
  • New to Flies
  • Pers. comm.
  • Author guidelines
  • Contact FlyBase
• Archives
  • Prior Release
  • Other Archives
  • Coordinate Converter

Gene Dmel\mei-W68

General Information
Symbol	Dmel\mei-W68	Species	D. melanogaster
Name	meiotic W68	Annotation symbol	CG7753
Feature type	protein_coding_gene	FlyBase ID	FBgn0002716
Gene Model Status	Current	Stock availability	6 publicly available
Also Known As	meiW68
Genomic Location
Chromosome (arm)	2R	Recombination map	2-94
Cytogenetic map	56D9-56D9	Sequence location	2R:15,343,675..15,347,029 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene meiotic W68 is referred to in FlyBase by the symbol Dmel\mei-W68 (CG7753, FBgn0002716). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: DNA topoisomerase type II (ATP-hydrolyzing) activity. There is experimental evidence that it is involved in the biological process: reciprocal meiotic recombination; meiotic DNA double-strand break processing; oogenesis; early meiotic recombination nodule assembly; late meiotic recombination nodule assembly. 13 alleles are reported. The phenotypes of these alleles are annotated with: early recombination nodule; late recombination nodule. It has one annotated transcript and one annotated polypeptide. Protein features are: DNA topoisomerase VI, subunit A; Spo11/DNA topoisomerase VI, subunit A. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of low expression to a trough of very low expression. Peak expression observed within 06-12 hour embryonic stages. Summary of FlyAtlas Anatomical Expression Data: No expression detected in any larval or adult organs/tissues. Comments on Affy2 ProbeSet: ProbeSet 1634534_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of mei-W68. Gene sequence location is 2R:15343675..15347029.
User Contributed Data
	Beta version, feedback welcome
Phenotypic Description from the Red Book (Lindsley & Zimm 1992)
Gene/Allele symbols may differ from current usage	mei-W68 (R.S. Hawley) Females homozygous for mei-w68 show a complete absence of meiotic recombination (Baker, unpublished data). Ultrastructural studies of pachytene reveal an absence of chromosome condensation and little synaptonemal complex (Carpenter, cited in Baker et al., 1976). A less severe allele (mei-w68L1-Lindsley) reduces exchange to approximately 60% of control levels and also alters the distribution of residual exchanges. Analysis of mitotic chromosome behavior (Baker et al., 1978) suggests that the mei-w68+ gene product is also required in mitotic cells.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 56D9-56D9   Limits computationally determined from genome sequence between P{lacW}l(2)k00705k00705&P{lacW}mei-W68k05603 and P{EP}CG11007EP736
Experimentally Determined Cytological Location
Cytogenetic map Notes References 56D-56D     (Hayashi-Hagihara, 1998.8.19) 56D8-56D10   (determined by in situ hybridisation)   (Spradling et al., 1999) 58D8-58D10   (determined by in situ hybridisation)   (BDGP Project Members, 1994-1999)
Experimentally Determined Recombination Data
Location	2-94
Left of (cM)	P{PZ}sm05338 P{PZ}emm1 P{lacW}par-1k06323 (McKim and Hayashi-Hagihara, 1998) sm emm par-1 (McKim, 1998.3.10)
Right of (cM)	RpL11 l(2)k00705 l(2)k09810 hts (McKim, 1998.3.10) P{lacW}l(2)k00705k00705 P{lacW}RpL11k16914 P{PZ}hts01103 P{PZ}l(2)0202902029 (McKim and Hayashi-Hagihara, 1998)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\mei-W68 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Shares 5' UTR with upstream gene. Gene model reviewed during 5.44 Low-frequency RNA-Seq exon junction(s) not annotated. Gene model reviewed during 5.48
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) mei-W68-RA FBtr0086461  NM_206179   2301   331
Additional Transcript Data & Comments
Reported size (kB)	2.4, 2.3, 2.1 (northern blot) (McKim and Hayashi-Hagihara, 1998)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein mei-W68-PA   FBpp0085657   37.1   331   7.18     NP_995901   AAF57553
Additional Polypeptide Data & Comments
Reported size (kDa)	331 (aa) (McKim and Hayashi-Hagihara, 1998)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Spo11/DNA topoisomerase VI, subunit A (IPR002815) DNA topoisomerase VI, subunit A (IPR004085)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA391205   AA540697   AA802712   AA948932   AE013599 AAF57553   AC004299   AF085276 AAC61735   AQ025035   AQ025763   AQ254816   BI240378   BI362483   BI373248   BT032934   BT120379   EC064182   GH942816   GH943548   GH945998   GH946047   GH947133   GH947555   GH950699   GH964200   GH967146   GH970366   GH976200   GH977490   GH983237
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q7KPA5
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
northern blot Stage Tissue/Position (including subcellular localization) Reference embryonic stage -- P-stage   organism   (McKim and Hayashi-Hagihara, 1998) adult stage | female     (McKim and Hayashi-Hagihara, 1998) germarium region 2   (McKim and Hayashi-Hagihara, 1998) germarium region 3   (McKim and Hayashi-Hagihara, 1998) adult stage | male   testis   (McKim and Hayashi-Hagihara, 1998)
Additional Descriptive Data
	mei-W68 transcripts are detected in embryos, larvae, pupae, and adult females on northern blots. They are detected weakly in male testis. Transcripts are detected by in situ hybridization in germarium regions 2 and 3. (McKim and Hayashi-Hagihara, 1998)
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: No expression detected in any larval or adult organs/tissues. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    3 Larval Midgut    8.1 Larval Hindgut    1.8 Larval Malpighian Tubules    5.3 Larval Fat Body    8.4 Larval Salivary Gland    2.2 Larval Trachea    0.475 Larval Carcass    2.55 Adult Head    2.8 Adult Eye    3.975 Adult Brain    4.1 Adult Thoracic-Abdominal Ganglion    3.2 Adult Crop    5.7 Adult Midgut    5.3 Adult Hindgut    2.5 Adult Malpighian Tubules    4.9 Adult Fat Body    6.7 Adult Salivary Gland    5 Adult Heart    1.325 Adult VirginFemale Spermatheca    6.7 Adult InseminatedFemale Spermatheca    3.9 Adult Ovary    7.8 Adult Testis    7.6 Adult Male Accessory Gland    6.1 Adult Carcass    4.9 Expression Level Scale  None   Low  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    3 Larval Midgut    8.1 Larval Hindgut    1.8 Larval Malpighian Tubules    5.3 Larval Fat Body    8.4 Larval Salivary Gland    2.2 Larval Trachea    0.475 Larval Carcass    2.55 Adult Head    2.8 Adult Eye    3.975 Adult Brain    4.1 Adult Thoracic-Abdominal Ganglion    3.2 Adult Crop    5.7 Adult Midgut    5.3 Adult Hindgut    2.5 Adult Malpighian Tubules    4.9 Adult Fat Body    6.7 Adult Salivary Gland    5 Adult Heart    1.325 Adult VirginFemale Spermatheca    6.7 Adult InseminatedFemale Spermatheca    3.9 Adult Ovary    7.8 Adult Testis    7.6 Adult Male Accessory Gland    6.1 Adult Carcass    4.9 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    3 Larval Midgut    8.1 Larval Hindgut    1.8 Larval Malpighian Tubules    5.3 Larval Fat Body    8.4 Larval Salivary Gland    2.2 Larval Trachea    0.475 Larval Carcass    2.55 Adult Head    2.8 Adult Eye    3.975 Adult Brain    4.1 Adult Thoracic-Abdominal Ganglion    3.2 Adult Crop    5.7 Adult Midgut    5.3 Adult Hindgut    2.5 Adult Malpighian Tubules    4.9 Adult Fat Body    6.7 Adult Salivary Gland    5 Adult Heart    1.325 Adult VirginFemale Spermatheca    6.7 Adult InseminatedFemale Spermatheca    3.9 Adult Ovary    7.8 Adult Testis    7.6 Adult Male Accessory Gland    6.1 Adult Carcass    4.9 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    3 Larval Midgut    8.1 Larval Hindgut    1.8 Larval Malpighian Tubules    5.3 Larval Fat Body    8.4 Larval Salivary Gland    2.2 Larval Trachea    0.475 Larval Carcass    2.55 Adult Head    2.8 Adult Eye    3.975 Adult Brain    4.1 Adult Thoracic-Abdominal Ganglion    3.2 Adult Crop    5.7 Adult Midgut    5.3 Adult Hindgut    2.5 Adult Malpighian Tubules    4.9 Adult Fat Body    6.7 Adult Salivary Gland    5 Adult Heart    1.325 Adult VirginFemale Spermatheca    6.7 Adult InseminatedFemale Spermatheca    3.9 Adult Ovary    7.8 Adult Testis    7.6 Adult Male Accessory Gland    6.1 Adult Carcass    4.9 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    3 Larval Midgut    8.1 Larval Hindgut    1.8 Larval Malpighian Tubules    5.3 Larval Fat Body    8.4 Larval Salivary Gland    2.2 Larval Trachea    0.475 Larval Carcass    2.55 Adult Head    2.8 Adult Eye    3.975 Adult Brain    4.1 Adult Thoracic-Abdominal Ganglion    3.2 Adult Crop    5.7 Adult Midgut    5.3 Adult Hindgut    2.5 Adult Malpighian Tubules    4.9 Adult Fat Body    6.7 Adult Salivary Gland    5 Adult Heart    1.325 Adult VirginFemale Spermatheca    6.7 Adult InseminatedFemale Spermatheca    3.9 Adult Ovary    7.8 Adult Testis    7.6 Adult Male Accessory Gland    6.1 Adult Carcass    4.9 Expression Level Scale  None   Low  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    3 Larval Midgut    8.1 Larval Hindgut    1.8 Larval Malpighian Tubules    5.3 Larval Fat Body    8.4 Larval Salivary Gland    2.2 Larval Trachea    0.475 Larval Carcass    2.55 Adult Head    2.8 Adult Eye    3.975 Adult Brain    4.1 Adult Thoracic-Abdominal Ganglion    3.2 Adult Crop    5.7 Adult Midgut    5.3 Adult Hindgut    2.5 Adult Malpighian Tubules    4.9 Adult Fat Body    6.7 Adult Salivary Gland    5 Adult Heart    1.325 Adult VirginFemale Spermatheca    6.7 Adult InseminatedFemale Spermatheca    3.9 Adult Ovary    7.8 Adult Testis    7.6 Adult Male Accessory Gland    6.1 Adult Carcass    4.9 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    3 Larval Midgut    8.1 Larval Hindgut    1.8 Larval Malpighian Tubules    5.3 Larval Fat Body    8.4 Larval Salivary Gland    2.2 Larval Trachea    0.475 Larval Carcass    2.55 Adult Head    2.8 Adult Eye    3.975 Adult Brain    4.1 Adult Thoracic-Abdominal Ganglion    3.2 Adult Crop    5.7 Adult Midgut    5.3 Adult Hindgut    2.5 Adult Malpighian Tubules    4.9 Adult Fat Body    6.7 Adult Salivary Gland    5 Adult Heart    1.325 Adult VirginFemale Spermatheca    6.7 Adult InseminatedFemale Spermatheca    3.9 Adult Ovary    7.8 Adult Testis    7.6 Adult Male Accessory Gland    6.1 Adult Carcass    4.9 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    3 Larval Midgut    8.1 Larval Hindgut    1.8 Larval Malpighian Tubules    5.3 Larval Fat Body    8.4 Larval Salivary Gland    2.2 Larval Trachea    0.475 Larval Carcass    2.55 Adult Head    2.8 Adult Eye    3.975 Adult Brain    4.1 Adult Thoracic-Abdominal Ganglion    3.2 Adult Crop    5.7 Adult Midgut    5.3 Adult Hindgut    2.5 Adult Malpighian Tubules    4.9 Adult Fat Body    6.7 Adult Salivary Gland    5 Adult Heart    1.325 Adult VirginFemale Spermatheca    6.7 Adult InseminatedFemale Spermatheca    3.9 Adult Ovary    7.8 Adult Testis    7.6 Adult Male Accessory Gland    6.1 Adult Carcass    4.9 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    2.8   NA  Eye    3.975   NA  Brain    4.1   3  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    3.2   NA  Crop    5.7   8.1  Midgut    5.3   1.8  Hindgut    2.5   5.3  Malpighian Tubules    4.9   8.4  Fat Body    6.7   2.2  Salivary Gland    5   NA  Heart    1.325   0.475  Trachea    NA   NA  VirginFemale Spermatheca    6.7   NA  InseminatedFemale Spermatheca    3.9   NA  Ovary    7.8   NA  Testis    7.6   NA  Male Accessory Gland    6.1   2.55  Carcass    4.9 FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    7 central nervous system, larvae L3    12 central nervous system, pupae P8    20 head, virgin 1-day female    6 head, virgin 4-day female    5 head, virgin 20-day female    8 head, mated 1-day female    5 head, mated 4-day female    6 head, mated 20-day female    7 head, mated 1-day male    8 head, mated 4-day male    9 head, mated 20-day male    11 salivary gland, larvae L3 wandering    3 salivary gland, white prepupae    9 digestive system, larvae L3 wandering    5 digestive system, 1-day adult    3 digestive system, 4-day adult    3 digestive system, 20-day adult    2 fat body, larvae L3 wandering    2 fat body, white prepupae    5 fat body, pupae P8    0 carcass, larvae L3 wandering    6 carcass, 1-day adult    4 carcass, 4-day adult    4 carcass, 20-day adult    3 ovary, virgin 4-day female    14 ovary, mated 4-day female    9 testis, mated 4-day male    1 accessory gland, mated 4-day male    2 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    7 central nervous system, larvae L3    12 central nervous system, pupae P8    20 head, virgin 1-day female    6 head, virgin 4-day female    5 head, virgin 20-day female    8 head, mated 1-day female    5 head, mated 4-day female    6 head, mated 20-day female    7 head, mated 1-day male    8 head, mated 4-day male    9 head, mated 20-day male    11 salivary gland, larvae L3 wandering    3 salivary gland, white prepupae    9 digestive system, larvae L3 wandering    5 digestive system, 1-day adult    3 digestive system, 4-day adult    3 digestive system, 20-day adult    2 fat body, larvae L3 wandering    2 fat body, white prepupae    5 fat body, pupae P8    0 carcass, larvae L3 wandering    6 carcass, 1-day adult    4 carcass, 4-day adult    4 carcass, 20-day adult    3 ovary, virgin 4-day female    14 ovary, mated 4-day female    9 testis, mated 4-day male    1 accessory gland, mated 4-day male    2 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    7 central nervous system, larvae L3    12 central nervous system, pupae P8    20 head, virgin 1-day female    6 head, virgin 4-day female    5 head, virgin 20-day female    8 head, mated 1-day female    5 head, mated 4-day female    6 head, mated 20-day female    7 head, mated 1-day male    8 head, mated 4-day male    9 head, mated 20-day male    11 salivary gland, larvae L3 wandering    3 salivary gland, white prepupae    9 digestive system, larvae L3 wandering    5 digestive system, 1-day adult    3 digestive system, 4-day adult    3 digestive system, 20-day adult    2 fat body, larvae L3 wandering    2 fat body, white prepupae    5 fat body, pupae P8    0 carcass, larvae L3 wandering    6 carcass, 1-day adult    4 carcass, 4-day adult    4 carcass, 20-day adult    3 ovary, virgin 4-day female    14 ovary, mated 4-day female    9 testis, mated 4-day male    1 accessory gland, mated 4-day male    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    7 central nervous system, larvae L3    12 central nervous system, pupae P8    20 head, virgin 1-day female    6 head, virgin 4-day female    5 head, virgin 20-day female    8 head, mated 1-day female    5 head, mated 4-day female    6 head, mated 20-day female    7 head, mated 1-day male    8 head, mated 4-day male    9 head, mated 20-day male    11 salivary gland, larvae L3 wandering    3 salivary gland, white prepupae    9 digestive system, larvae L3 wandering    5 digestive system, 1-day adult    3 digestive system, 4-day adult    3 digestive system, 20-day adult    2 fat body, larvae L3 wandering    2 fat body, white prepupae    5 fat body, pupae P8    0 carcass, larvae L3 wandering    6 carcass, 1-day adult    4 carcass, 4-day adult    4 carcass, 20-day adult    3 ovary, virgin 4-day female    14 ovary, mated 4-day female    9 testis, mated 4-day male    1 accessory gland, mated 4-day male    2 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    7 central nervous system, larvae L3    12 central nervous system, pupae P8    20 head, virgin 1-day female    6 head, virgin 4-day female    5 head, virgin 20-day female    8 head, mated 1-day female    5 head, mated 4-day female    6 head, mated 20-day female    7 head, mated 1-day male    8 head, mated 4-day male    9 head, mated 20-day male    11 salivary gland, larvae L3 wandering    3 salivary gland, white prepupae    9 digestive system, larvae L3 wandering    5 digestive system, 1-day adult    3 digestive system, 4-day adult    3 digestive system, 20-day adult    2 fat body, larvae L3 wandering    2 fat body, white prepupae    5 fat body, pupae P8    0 carcass, larvae L3 wandering    6 carcass, 1-day adult    4 carcass, 4-day adult    4 carcass, 20-day adult    3 ovary, virgin 4-day female    14 ovary, mated 4-day female    9 testis, mated 4-day male    1 accessory gland, mated 4-day male    2 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    7 central nervous system, larvae L3    12 central nervous system, pupae P8    20 head, virgin 1-day female    6 head, virgin 4-day female    5 head, virgin 20-day female    8 head, mated 1-day female    5 head, mated 4-day female    6 head, mated 20-day female    7 head, mated 1-day male    8 head, mated 4-day male    9 head, mated 20-day male    11 salivary gland, larvae L3 wandering    3 salivary gland, white prepupae    9 digestive system, larvae L3 wandering    5 digestive system, 1-day adult    3 digestive system, 4-day adult    3 digestive system, 20-day adult    2 fat body, larvae L3 wandering    2 fat body, white prepupae    5 fat body, pupae P8    0 carcass, larvae L3 wandering    6 carcass, 1-day adult    4 carcass, 4-day adult    4 carcass, 20-day adult    3 ovary, virgin 4-day female    14 ovary, mated 4-day female    9 testis, mated 4-day male    1 accessory gland, mated 4-day male    2 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    7 central nervous system, larvae L3    12 central nervous system, pupae P8    20 head, virgin 1-day female    6 head, virgin 4-day female    5 head, virgin 20-day female    8 head, mated 1-day female    5 head, mated 4-day female    6 head, mated 20-day female    7 head, mated 1-day male    8 head, mated 4-day male    9 head, mated 20-day male    11 salivary gland, larvae L3 wandering    3 salivary gland, white prepupae    9 digestive system, larvae L3 wandering    5 digestive system, 1-day adult    3 digestive system, 4-day adult    3 digestive system, 20-day adult    2 fat body, larvae L3 wandering    2 fat body, white prepupae    5 fat body, pupae P8    0 carcass, larvae L3 wandering    6 carcass, 1-day adult    4 carcass, 4-day adult    4 carcass, 20-day adult    3 ovary, virgin 4-day female    14 ovary, mated 4-day female    9 testis, mated 4-day male    1 accessory gland, mated 4-day male    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    7 central nervous system, larvae L3    12 central nervous system, pupae P8    20 head, virgin 1-day female    6 head, virgin 4-day female    5 head, virgin 20-day female    8 head, mated 1-day female    5 head, mated 4-day female    6 head, mated 20-day female    7 head, mated 1-day male    8 head, mated 4-day male    9 head, mated 20-day male    11 salivary gland, larvae L3 wandering    3 salivary gland, white prepupae    9 digestive system, larvae L3 wandering    5 digestive system, 1-day adult    3 digestive system, 4-day adult    3 digestive system, 20-day adult    2 fat body, larvae L3 wandering    2 fat body, white prepupae    5 fat body, pupae P8    0 carcass, larvae L3 wandering    6 carcass, 1-day adult    4 carcass, 4-day adult    4 carcass, 20-day adult    3 ovary, virgin 4-day female    14 ovary, mated 4-day female    9 testis, mated 4-day male    1 accessory gland, mated 4-day male    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of low expression to a trough of very low expression. Peak expression observed within 06-12 hour embryonic stages. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    14 embryo 02-04hr    10 embryo 04-06hr    7 embryo 06-08hr    9 embryo 08-10hr    11 embryo 10-12hr    8 embryo 12-14hr    13 embryo 14-16hr    6 embryo 16-18hr    9 embryo 18-20hr    5 embryo 20-22hr    7 embryo 22-24hr    10 larva L1    4 larva L2    4 larva L3 12hr old    3 larva L3 puffstage 1-2    2 larva L3 puffstage 3-6    5 larva L3 puffstage 7-9    8 white prepupae new    8 white prepupae 12hr    8 white prepupae 24hr    8 pupae 2d postWPP    7 pupae 3d postWPP    5 pupae 4d postWPP    2 adult male 01day    4 adult male 05day    4 adult male 30day    3 adult female 01day    5 adult female 05day    15 adult female 30day    13 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    14 embryo 02-04hr    10 embryo 04-06hr    7 embryo 06-08hr    9 embryo 08-10hr    11 embryo 10-12hr    8 embryo 12-14hr    13 embryo 14-16hr    6 embryo 16-18hr    9 embryo 18-20hr    5 embryo 20-22hr    7 embryo 22-24hr    10 larva L1    4 larva L2    4 larva L3 12hr old    3 larva L3 puffstage 1-2    2 larva L3 puffstage 3-6    5 larva L3 puffstage 7-9    8 white prepupae new    8 white prepupae 12hr    8 white prepupae 24hr    8 pupae 2d postWPP    7 pupae 3d postWPP    5 pupae 4d postWPP    2 adult male 01day    4 adult male 05day    4 adult male 30day    3 adult female 01day    5 adult female 05day    15 adult female 30day    13 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    14 embryo 02-04hr    10 embryo 04-06hr    7 embryo 06-08hr    9 embryo 08-10hr    11 embryo 10-12hr    8 embryo 12-14hr    13 embryo 14-16hr    6 embryo 16-18hr    9 embryo 18-20hr    5 embryo 20-22hr    7 embryo 22-24hr    10 larva L1    4 larva L2    4 larva L3 12hr old    3 larva L3 puffstage 1-2    2 larva L3 puffstage 3-6    5 larva L3 puffstage 7-9    8 white prepupae new    8 white prepupae 12hr    8 white prepupae 24hr    8 pupae 2d postWPP    7 pupae 3d postWPP    5 pupae 4d postWPP    2 adult male 01day    4 adult male 05day    4 adult male 30day    3 adult female 01day    5 adult female 05day    15 adult female 30day    13 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    14 embryo 02-04hr    10 embryo 04-06hr    7 embryo 06-08hr    9 embryo 08-10hr    11 embryo 10-12hr    8 embryo 12-14hr    13 embryo 14-16hr    6 embryo 16-18hr    9 embryo 18-20hr    5 embryo 20-22hr    7 embryo 22-24hr    10 larva L1    4 larva L2    4 larva L3 12hr old    3 larva L3 puffstage 1-2    2 larva L3 puffstage 3-6    5 larva L3 puffstage 7-9    8 white prepupae new    8 white prepupae 12hr    8 white prepupae 24hr    8 pupae 2d postWPP    7 pupae 3d postWPP    5 pupae 4d postWPP    2 adult male 01day    4 adult male 05day    4 adult male 30day    3 adult female 01day    5 adult female 05day    15 adult female 30day    13 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    14 embryo 02-04hr    10 embryo 04-06hr    7 embryo 06-08hr    9 embryo 08-10hr    11 embryo 10-12hr    8 embryo 12-14hr    13 embryo 14-16hr    6 embryo 16-18hr    9 embryo 18-20hr    5 embryo 20-22hr    7 embryo 22-24hr    10 larva L1    4 larva L2    4 larva L3 12hr old    3 larva L3 puffstage 1-2    2 larva L3 puffstage 3-6    5 larva L3 puffstage 7-9    8 white prepupae new    8 white prepupae 12hr    8 white prepupae 24hr    8 pupae 2d postWPP    7 pupae 3d postWPP    5 pupae 4d postWPP    2 adult male 01day    4 adult male 05day    4 adult male 30day    3 adult female 01day    5 adult female 05day    15 adult female 30day    13 Expression Level Scale  Very low   Low   Moderate  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    14 embryo 02-04hr    10 embryo 04-06hr    7 embryo 06-08hr    9 embryo 08-10hr    11 embryo 10-12hr    8 embryo 12-14hr    13 embryo 14-16hr    6 embryo 16-18hr    9 embryo 18-20hr    5 embryo 20-22hr    7 embryo 22-24hr    10 larva L1    4 larva L2    4 larva L3 12hr old    3 larva L3 puffstage 1-2    2 larva L3 puffstage 3-6    5 larva L3 puffstage 7-9    8 white prepupae new    8 white prepupae 12hr    8 white prepupae 24hr    8 pupae 2d postWPP    7 pupae 3d postWPP    5 pupae 4d postWPP    2 adult male 01day    4 adult male 05day    4 adult male 30day    3 adult female 01day    5 adult female 05day    15 adult female 30day    13 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    14 embryo 02-04hr    10 embryo 04-06hr    7 embryo 06-08hr    9 embryo 08-10hr    11 embryo 10-12hr    8 embryo 12-14hr    13 embryo 14-16hr    6 embryo 16-18hr    9 embryo 18-20hr    5 embryo 20-22hr    7 embryo 22-24hr    10 larva L1    4 larva L2    4 larva L3 12hr old    3 larva L3 puffstage 1-2    2 larva L3 puffstage 3-6    5 larva L3 puffstage 7-9    8 white prepupae new    8 white prepupae 12hr    8 white prepupae 24hr    8 pupae 2d postWPP    7 pupae 3d postWPP    5 pupae 4d postWPP    2 adult male 01day    4 adult male 05day    4 adult male 30day    3 adult female 01day    5 adult female 05day    15 adult female 30day    13 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    14 embryo 02-04hr    10 embryo 04-06hr    7 embryo 06-08hr    9 embryo 08-10hr    11 embryo 10-12hr    8 embryo 12-14hr    13 embryo 14-16hr    6 embryo 16-18hr    9 embryo 18-20hr    5 embryo 20-22hr    7 embryo 22-24hr    10 larva L1    4 larva L2    4 larva L3 12hr old    3 larva L3 puffstage 1-2    2 larva L3 puffstage 3-6    5 larva L3 puffstage 7-9    8 white prepupae new    8 white prepupae 12hr    8 white prepupae 24hr    8 pupae 2d postWPP    7 pupae 3d postWPP    5 pupae 4d postWPP    2 adult male 01day    4 adult male 05day    4 adult male 30day    3 adult female 01day    5 adult female 05day    15 adult female 30day    13 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    16 Schneider line 2 Sg4    6 embryonic 1182-4H    4 embryonic GM2    16 embryonic Kc167    6 embryonic S1    6 embryonic S3    11 leg disc CME L1    3 wing disc CME-W2    7 wing disc ML-DmD8    6 wing disc ML-DmD9    1 wing disc ML-DmD16-c3    5 wing disc ML-DmD21    1 wing disc ML-DmD32    2 haltere disc ML-DmD17-c3    11 eye-antennal disc ML-DmD11    5 antennal disc ML-DmD20-c5    2 mixed discs ML-DmD4-c1    4 CNS ML-DmBG1-c1    7 CNS ML-DmBG2-c2    6 tumorous blood cells mbn2    15 ovary fGS/OSS    5 ovary OSC    8 ovary OSS    4 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    16 Schneider line 2 Sg4    6 embryonic 1182-4H    4 embryonic GM2    16 embryonic Kc167    6 embryonic S1    6 embryonic S3    11 leg disc CME L1    3 wing disc CME-W2    7 wing disc ML-DmD8    6 wing disc ML-DmD9    1 wing disc ML-DmD16-c3    5 wing disc ML-DmD21    1 wing disc ML-DmD32    2 haltere disc ML-DmD17-c3    11 eye-antennal disc ML-DmD11    5 antennal disc ML-DmD20-c5    2 mixed discs ML-DmD4-c1    4 CNS ML-DmBG1-c1    7 CNS ML-DmBG2-c2    6 tumorous blood cells mbn2    15 ovary fGS/OSS    5 ovary OSC    8 ovary OSS    4 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    16 Schneider line 2 Sg4    6 embryonic 1182-4H    4 embryonic GM2    16 embryonic Kc167    6 embryonic S1    6 embryonic S3    11 leg disc CME L1    3 wing disc CME-W2    7 wing disc ML-DmD8    6 wing disc ML-DmD9    1 wing disc ML-DmD16-c3    5 wing disc ML-DmD21    1 wing disc ML-DmD32    2 haltere disc ML-DmD17-c3    11 eye-antennal disc ML-DmD11    5 antennal disc ML-DmD20-c5    2 mixed discs ML-DmD4-c1    4 CNS ML-DmBG1-c1    7 CNS ML-DmBG2-c2    6 tumorous blood cells mbn2    15 ovary fGS/OSS    5 ovary OSC    8 ovary OSS    4 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    16 Schneider line 2 Sg4    6 embryonic 1182-4H    4 embryonic GM2    16 embryonic Kc167    6 embryonic S1    6 embryonic S3    11 leg disc CME L1    3 wing disc CME-W2    7 wing disc ML-DmD8    6 wing disc ML-DmD9    1 wing disc ML-DmD16-c3    5 wing disc ML-DmD21    1 wing disc ML-DmD32    2 haltere disc ML-DmD17-c3    11 eye-antennal disc ML-DmD11    5 antennal disc ML-DmD20-c5    2 mixed discs ML-DmD4-c1    4 CNS ML-DmBG1-c1    7 CNS ML-DmBG2-c2    6 tumorous blood cells mbn2    15 ovary fGS/OSS    5 ovary OSC    8 ovary OSS    4 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    16 Schneider line 2 Sg4    6 embryonic 1182-4H    4 embryonic GM2    16 embryonic Kc167    6 embryonic S1    6 embryonic S3    11 leg disc CME L1    3 wing disc CME-W2    7 wing disc ML-DmD8    6 wing disc ML-DmD9    1 wing disc ML-DmD16-c3    5 wing disc ML-DmD21    1 wing disc ML-DmD32    2 haltere disc ML-DmD17-c3    11 eye-antennal disc ML-DmD11    5 antennal disc ML-DmD20-c5    2 mixed discs ML-DmD4-c1    4 CNS ML-DmBG1-c1    7 CNS ML-DmBG2-c2    6 tumorous blood cells mbn2    15 ovary fGS/OSS    5 ovary OSC    8 ovary OSS    4 Expression Level Scale  Very low   Low   Moderate  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    16 Schneider line 2 Sg4    6 embryonic 1182-4H    4 embryonic GM2    16 embryonic Kc167    6 embryonic S1    6 embryonic S3    11 leg disc CME L1    3 wing disc CME-W2    7 wing disc ML-DmD8    6 wing disc ML-DmD9    1 wing disc ML-DmD16-c3    5 wing disc ML-DmD21    1 wing disc ML-DmD32    2 haltere disc ML-DmD17-c3    11 eye-antennal disc ML-DmD11    5 antennal disc ML-DmD20-c5    2 mixed discs ML-DmD4-c1    4 CNS ML-DmBG1-c1    7 CNS ML-DmBG2-c2    6 tumorous blood cells mbn2    15 ovary fGS/OSS    5 ovary OSC    8 ovary OSS    4 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    16 Schneider line 2 Sg4    6 embryonic 1182-4H    4 embryonic GM2    16 embryonic Kc167    6 embryonic S1    6 embryonic S3    11 leg disc CME L1    3 wing disc CME-W2    7 wing disc ML-DmD8    6 wing disc ML-DmD9    1 wing disc ML-DmD16-c3    5 wing disc ML-DmD21    1 wing disc ML-DmD32    2 haltere disc ML-DmD17-c3    11 eye-antennal disc ML-DmD11    5 antennal disc ML-DmD20-c5    2 mixed discs ML-DmD4-c1    4 CNS ML-DmBG1-c1    7 CNS ML-DmBG2-c2    6 tumorous blood cells mbn2    15 ovary fGS/OSS    5 ovary OSC    8 ovary OSS    4 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    16 Schneider line 2 Sg4    6 embryonic 1182-4H    4 embryonic GM2    16 embryonic Kc167    6 embryonic S1    6 embryonic S3    11 leg disc CME L1    3 wing disc CME-W2    7 wing disc ML-DmD8    6 wing disc ML-DmD9    1 wing disc ML-DmD16-c3    5 wing disc ML-DmD21    1 wing disc ML-DmD32    2 haltere disc ML-DmD17-c3    11 eye-antennal disc ML-DmD11    5 antennal disc ML-DmD20-c5    2 mixed discs ML-DmD4-c1    4 CNS ML-DmBG1-c1    7 CNS ML-DmBG2-c2    6 tumorous blood cells mbn2    15 ovary fGS/OSS    5 ovary OSC    8 ovary OSS    4 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    1 cold shock, 4-day adult    2 heat shock, 4-day adult    4 Cadmium 50 mM 6 hrs, larvae L3    1 Cadmium 50 mM 12 hrs, larvae L3    4 Cadmium 50 mM 48 hrs, 4-day adult    4 Cadmium 100 mM 48 hrs, 4-day adult    10 Copper 0.5 mM 12 hrs, larvae L3    2 Copper 15 mM 48 hrs, 4-day adult    4 Zinc 5 mM 12 hrs, larvae L3    1 Zinc 4.5 mM 48 hrs, 4-day adult    3 Ethanol 2.5% 3 hrs, larvae L3    6 Ethanol 5% 3 hrs, larvae L3    4 Ethanol 10% 3 hrs, larvae L3    2 Caffeine 1.5 mg/ml 4 hrs, larvae L3    3 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    5 Caffeine 25 mg/ml 48 hrs, 4-day adult    3 Paraquat 5 mM 48 hrs, 4-day adult    5 Paraquat 10 mM 48 hrs, 4-day adult    5 Rotenone 2 μg 12 hrs, larvae L3    3 Rotenone 8 μg 12 hrs, larvae L3    1 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    1 cold shock, 4-day adult    2 heat shock, 4-day adult    4 Cadmium 50 mM 6 hrs, larvae L3    1 Cadmium 50 mM 12 hrs, larvae L3    4 Cadmium 50 mM 48 hrs, 4-day adult    4 Cadmium 100 mM 48 hrs, 4-day adult    10 Copper 0.5 mM 12 hrs, larvae L3    2 Copper 15 mM 48 hrs, 4-day adult    4 Zinc 5 mM 12 hrs, larvae L3    1 Zinc 4.5 mM 48 hrs, 4-day adult    3 Ethanol 2.5% 3 hrs, larvae L3    6 Ethanol 5% 3 hrs, larvae L3    4 Ethanol 10% 3 hrs, larvae L3    2 Caffeine 1.5 mg/ml 4 hrs, larvae L3    3 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    5 Caffeine 25 mg/ml 48 hrs, 4-day adult    3 Paraquat 5 mM 48 hrs, 4-day adult    5 Paraquat 10 mM 48 hrs, 4-day adult    5 Rotenone 2 μg 12 hrs, larvae L3    3 Rotenone 8 μg 12 hrs, larvae L3    1 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    1 cold shock, 4-day adult    2 heat shock, 4-day adult    4 Cadmium 50 mM 6 hrs, larvae L3    1 Cadmium 50 mM 12 hrs, larvae L3    4 Cadmium 50 mM 48 hrs, 4-day adult    4 Cadmium 100 mM 48 hrs, 4-day adult    10 Copper 0.5 mM 12 hrs, larvae L3    2 Copper 15 mM 48 hrs, 4-day adult    4 Zinc 5 mM 12 hrs, larvae L3    1 Zinc 4.5 mM 48 hrs, 4-day adult    3 Ethanol 2.5% 3 hrs, larvae L3    6 Ethanol 5% 3 hrs, larvae L3    4 Ethanol 10% 3 hrs, larvae L3    2 Caffeine 1.5 mg/ml 4 hrs, larvae L3    3 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    5 Caffeine 25 mg/ml 48 hrs, 4-day adult    3 Paraquat 5 mM 48 hrs, 4-day adult    5 Paraquat 10 mM 48 hrs, 4-day adult    5 Rotenone 2 μg 12 hrs, larvae L3    3 Rotenone 8 μg 12 hrs, larvae L3    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    1 cold shock, 4-day adult    2 heat shock, 4-day adult    4 Cadmium 50 mM 6 hrs, larvae L3    1 Cadmium 50 mM 12 hrs, larvae L3    4 Cadmium 50 mM 48 hrs, 4-day adult    4 Cadmium 100 mM 48 hrs, 4-day adult    10 Copper 0.5 mM 12 hrs, larvae L3    2 Copper 15 mM 48 hrs, 4-day adult    4 Zinc 5 mM 12 hrs, larvae L3    1 Zinc 4.5 mM 48 hrs, 4-day adult    3 Ethanol 2.5% 3 hrs, larvae L3    6 Ethanol 5% 3 hrs, larvae L3    4 Ethanol 10% 3 hrs, larvae L3    2 Caffeine 1.5 mg/ml 4 hrs, larvae L3    3 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    5 Caffeine 25 mg/ml 48 hrs, 4-day adult    3 Paraquat 5 mM 48 hrs, 4-day adult    5 Paraquat 10 mM 48 hrs, 4-day adult    5 Rotenone 2 μg 12 hrs, larvae L3    3 Rotenone 8 μg 12 hrs, larvae L3    1 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    1 cold shock, 4-day adult    2 heat shock, 4-day adult    4 Cadmium 50 mM 6 hrs, larvae L3    1 Cadmium 50 mM 12 hrs, larvae L3    4 Cadmium 50 mM 48 hrs, 4-day adult    4 Cadmium 100 mM 48 hrs, 4-day adult    10 Copper 0.5 mM 12 hrs, larvae L3    2 Copper 15 mM 48 hrs, 4-day adult    4 Zinc 5 mM 12 hrs, larvae L3    1 Zinc 4.5 mM 48 hrs, 4-day adult    3 Ethanol 2.5% 3 hrs, larvae L3    6 Ethanol 5% 3 hrs, larvae L3    4 Ethanol 10% 3 hrs, larvae L3    2 Caffeine 1.5 mg/ml 4 hrs, larvae L3    3 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    5 Caffeine 25 mg/ml 48 hrs, 4-day adult    3 Paraquat 5 mM 48 hrs, 4-day adult    5 Paraquat 10 mM 48 hrs, 4-day adult    5 Rotenone 2 μg 12 hrs, larvae L3    3 Rotenone 8 μg 12 hrs, larvae L3    1 Expression Level Scale  Very low   Low   Moderate  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    1 cold shock, 4-day adult    2 heat shock, 4-day adult    4 Cadmium 50 mM 6 hrs, larvae L3    1 Cadmium 50 mM 12 hrs, larvae L3    4 Cadmium 50 mM 48 hrs, 4-day adult    4 Cadmium 100 mM 48 hrs, 4-day adult    10 Copper 0.5 mM 12 hrs, larvae L3    2 Copper 15 mM 48 hrs, 4-day adult    4 Zinc 5 mM 12 hrs, larvae L3    1 Zinc 4.5 mM 48 hrs, 4-day adult    3 Ethanol 2.5% 3 hrs, larvae L3    6 Ethanol 5% 3 hrs, larvae L3    4 Ethanol 10% 3 hrs, larvae L3    2 Caffeine 1.5 mg/ml 4 hrs, larvae L3    3 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    5 Caffeine 25 mg/ml 48 hrs, 4-day adult    3 Paraquat 5 mM 48 hrs, 4-day adult    5 Paraquat 10 mM 48 hrs, 4-day adult    5 Rotenone 2 μg 12 hrs, larvae L3    3 Rotenone 8 μg 12 hrs, larvae L3    1 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    1 cold shock, 4-day adult    2 heat shock, 4-day adult    4 Cadmium 50 mM 6 hrs, larvae L3    1 Cadmium 50 mM 12 hrs, larvae L3    4 Cadmium 50 mM 48 hrs, 4-day adult    4 Cadmium 100 mM 48 hrs, 4-day adult    10 Copper 0.5 mM 12 hrs, larvae L3    2 Copper 15 mM 48 hrs, 4-day adult    4 Zinc 5 mM 12 hrs, larvae L3    1 Zinc 4.5 mM 48 hrs, 4-day adult    3 Ethanol 2.5% 3 hrs, larvae L3    6 Ethanol 5% 3 hrs, larvae L3    4 Ethanol 10% 3 hrs, larvae L3    2 Caffeine 1.5 mg/ml 4 hrs, larvae L3    3 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    5 Caffeine 25 mg/ml 48 hrs, 4-day adult    3 Paraquat 5 mM 48 hrs, 4-day adult    5 Paraquat 10 mM 48 hrs, 4-day adult    5 Rotenone 2 μg 12 hrs, larvae L3    3 Rotenone 8 μg 12 hrs, larvae L3    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    1 cold shock, 4-day adult    2 heat shock, 4-day adult    4 Cadmium 50 mM 6 hrs, larvae L3    1 Cadmium 50 mM 12 hrs, larvae L3    4 Cadmium 50 mM 48 hrs, 4-day adult    4 Cadmium 100 mM 48 hrs, 4-day adult    10 Copper 0.5 mM 12 hrs, larvae L3    2 Copper 15 mM 48 hrs, 4-day adult    4 Zinc 5 mM 12 hrs, larvae L3    1 Zinc 4.5 mM 48 hrs, 4-day adult    3 Ethanol 2.5% 3 hrs, larvae L3    6 Ethanol 5% 3 hrs, larvae L3    4 Ethanol 10% 3 hrs, larvae L3    2 Caffeine 1.5 mg/ml 4 hrs, larvae L3    3 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    5 Caffeine 25 mg/ml 48 hrs, 4-day adult    3 Paraquat 5 mM 48 hrs, 4-day adult    5 Paraquat 10 mM 48 hrs, 4-day adult    5 Rotenone 2 μg 12 hrs, larvae L3    3 Rotenone 8 μg 12 hrs, larvae L3    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (Graveley et al., 2011) mE1_20_mRNA_expression_cluster_07
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0002716 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG30132-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal | recessive mei-W68k05603 mei-W68W3 viable mei-W68k05603 viable, with Scer\GAL4[-]: mei-W68EP1144 Other Phenotypes Allele meiotic cell cycle defective mei-W681 mei-W684572 wild-type, with Scer\GAL4[-]: mei-W68EP899 Phenotype manifest in Allele early recombination nodule mei-W681 mei-W68L1 late recombination nodule mei-W681
Classical Alleles ( 11 )
For All Classical Alleles Show
Allele of mei-W68 Class Mutagen Stocks Known lesion mei-W68k05603 hypomorphic allele - genetic evidence P-element activity 3 Yes mei-W681 spontaneous 2 Yes mei-W684572 0 -- mei-W68DG23501 P-element activity 0 -- mei-W68EP1144 hypomorphic allele - genetic evidence P-element activity 0 -- mei-W68EP899 P-element activity 0 Yes mei-W68EY08397 P-element activity 0 Yes mei-W68k06821b P-element activity 0 Yes mei-W68L1 hypomorphic allele - genetic evidence ethyl methanesulfonate 0 -- mei-W68unspecified 0 -- mei-W68W3 P-element activity 0 Yes
Alleles Carried on Transgenic Constructs ( 2 )
For All Alleles Carried on Transgenic Constructs Show
Allele of mei-W68 Class Mutagen Stocks Known lesion mei-W68KK109695 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes mei-W68GD16231 in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(2R)LD3 (McKim and Hayashi-Hagihara, 1998) Df(2R)LL4 (McKim and Hayashi-Hagihara, 1998) Df(2R)LL5 (McKim and Hayashi-Hagihara, 1998)
Not disrupted in	Df(2R)017 (McKim and Hayashi-Hagihara, 1998) Df(2R)AA21 (McKim and Hayashi-Hagihara, 1998) Df(2R)E3578 (BDGP Project Members, 1994-1999) Df(2R)P34 (McKim and Hayashi-Hagihara, 1998) Df(2R)X58-7 (BDGP Project Members, 1994-1999)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD16231} NA P{KK109695} NA
Insertions
	Type of insertions Name Expression data insertion of mobile activating element P{EP}mei-W68EP899 NA P{EP}mei-W68EP1144 NA P{EPgy2}mei-W68EY08397 NA insertion of enhancer trap P{lacW}mei-W68k05603 No P{lacW}mei-W68k06821b No miscellaneous insertions ?{}mei-W681 NA P{?EP}mei-W68W3 NA P{wHy}mei-W68DG23501 NA
Gene Ontology: Function, Process & Cellular Component ( 10 unique terms )
Terms Based on Experimental Evidence ( 5 terms )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
early meiotic recombination nodule assembly inferred from mutant phenotype (Carpenter, 2003) late meiotic recombination nodule assembly inferred from mutant phenotype (Carpenter, 2003) meiotic DNA double-strand break processing inferred from direct assay (Joyce et al., 2011) oogenesis inferred from genetic interaction with p53, okr (Lu et al., 2010) reciprocal meiotic recombination inferred from mutant phenotype (McKim et al., 1998)
Cellular Component ( 0 terms)
Terms Based on Predictions or Assertions ( 6 terms )
Molecular Function
CV term Evidence References
ATP binding inferred from electronic annotation with InterPro:IPR002815 (FlyBase Curators et al., 2004-) DNA topoisomerase type II (ATP-hydrolyzing) activity inferred from sequence or structural similarity with UniProtKB:O05208 (FlyBase, 1992-) non-traceable author statement (Hayashi-Hagihara, 1998.8.19)
Biological Process
CV term Evidence References
DNA topological change inferred from electronic annotation with InterPro:IPR004085 (FlyBase Curators et al., 2004-) meiotic DNA double-strand break formation non-traceable author statement (Liu and McKim, 2000) reciprocal meiotic recombination traceable author statement (Shulman et al., 2000, McKim et al., 2000)
Cellular Component
CV term Evidence References
chromosome inferred from electronic annotation with InterPro:IPR002815, InterPro:IPR004085 (FlyBase Curators et al., 2004-)
Sequence Ontology: Class of Gene
	gene_with_dicistronic_primary_transcript (FlyBase Genome Annotators, 2004) nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions mei-W68 allele Gene References mei-W681 spn-B (Liu et al., 2000, Liu et al., 2002) mei-W68unspecified mus301 (Ghabrial and Schupbach, 1999) okr (Ghabrial and Schupbach, 1999) spn-B (Ghabrial and Schupbach, 1999) spn-D (Abdu et al., 2003) unspecified mei-41 (Ghabrial and Schupbach, 1999) spn-A (Staeva-Vieira et al., 2003)
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 77703 DroID - A comprehensive database of gene and protein interactions. • FBgn0002716 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 2768853
Orthologs
OrthoDB Orthologs (40) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG6QFX0G Dipteran inclusive ortholog search EOG6QFWP5 Insect inclusive ortholog search EOG6KPS7D Arthropod inclusive ortholog search EOG6JM665 Metazoa inclusive ortholog search EOG64V238
Orthologs in Drosophila Species (EOG6QFX0G)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\mei-W68     Drosophila simulans   Dsim\GD11457 Y   Drosophila sechellia   Dsec\GM21963 Y   Drosophila sechellia   Dsec\GM13291     Drosophila erecta   Dere\GG21975 Y   Drosophila yakuba   Dyak\GE12053 Y   Drosophila ananassae   Dana\GF11715 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA24396 Y   Drosophila persimilis   Dper\GL10528 Y   Drosophila willistoni   Dwil\GK15872 Y   Drosophila virilis   Dvir\GJ20469 Y   Drosophila mojavensis   Dmoj\GI20732 Y   Drosophila grimshawi   Dgri\GH20206 Y
Orthologs in non-Drosophila Dipterans (EOG6QFWP5)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL013701   Anopheles gambiae Malaria mosquito  Agam\AGAP010898   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ003179
Orthologs in non-Dipteran Insects (EOG6KPS7D)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\mei-W68   Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG023760   Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH10418   Atta cephalotes Leafcutter ant  Acep\ACEP23385   Camponotus floridanus Florida carpenter ant  Cflo\CFLO22812   Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL19251   Linepithema humile Argentine ant  Lhum\LH18634   Pogonomyrmex barbatus Red harvester ant  Pbar\PB13440   Pogonomyrmex barbatus Red harvester ant  Pbar\PB13439   Solenopsis invicta Red fire ant  Sinv\SINV21703   Acyrthosiphon pisum Pea aphid  Apim\ACYPI24707   Bombyx mori Silkmoth  Bmor\BGIBMGA005968   Pediculus humanus Human body louse  Phum\PHUM436850   Tribolium castaneum Red flour beetle  Tcas\TC013087
Orthologs in non-Insect Arthropods (EOG6JM665)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\Stat6   Ixodes scapularis Deer tick  Isca\ISCW022447
Orthologs in non-Arthropod Metazoa (EOG64V238)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Caenorhabditis elegans Nematode  Cele\spo-11   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_017861gn   Danio rerio Zebrafish  Drer\spo11   Xenopus tropicalis Western clawed frog  Xtro\spo11   Gallus gallus Domestic chicken  Ggal\SPO11   Mus musculus House mouse  Mmus\Spo11   Rattus norvegicus Norway rat  Rnor\Spo11   Homo sapiens Human  Hsap\ENSG00000054796
Human Orthologs (1)
Gene OMIM HGNC Hsap\ENSG00000054796
AAA Orthologs (11) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD11457 Drosophila sechellia Dsec\GM21963 Drosophila erecta Dere\GG21975 Drosophila yakuba Dyak\GE12053 Drosophila ananassae Dana\GF11715 Drosophila pseudoobscura pseudoobscura Dpse\GA24396 Drosophila persimilis Dper\GL10528 Drosophila willistoni Dwil\GK15872 Drosophila virilis Dvir\GJ20469 Drosophila mojavensis Dmoj\GI20732 Drosophila grimshawi Dgri\GH20206
Stocks & Reagents
Stocks Listed in FlyBase ( 6 )
Bloomington	4932 y1/Dp(1;Y)y+; mei-W681/CyO 10574 y1 w67c23; P{lacW}mei-W68k05603 par-1k05603/CyO
Kyoto	107952 y1/Dp(1;Y)y+; mei-W681/CyO 108858 y1 w67c23; P{lacW}mei-W68k05603/CyO 111182 yd2 w1118 P{ey-FLP.N}2 P{GMR-lacZ.C(38.1)}TPN1; P{neoFRT}42D P{lacW}mei-W68k05603 /CyO y+
VDRC	v101798 P{KK109695}VIE-260B
Genomic Clones ( 1 )
	BACR25K02 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 21 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones
Other clones	IP20426 RT05903
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	GM06191 LD10429 LD27632 RE37214 RE60494
Other clones	79349 RP004168768 RP004207326 RP004212549 RP004212951 RP004223303 RP004225216 RP004249399 RP004254438 RP004289828 RP004324993 RP004428338 RP004470698 RP004506987
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0002716 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 2768853
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: mei-W68 CG7753 (Milshina, 1999.11)
Source for database merge of
Additional comments	One or more of the processed transcripts for this gene share(s) untranslated sequences with a transcript of an adjacent gene, but encode(s) a single open reading frame (ORF). The non-overlapping ORFs that share untranslated sequences are represented by par-1 and mei-W68. (FlyBase Genome Annotators, 2004) mei-W68 shares a promoter and 5'-UTR with the N1 class of par-1 transcripts and the coding sequence of mei-W68 falls entirely within the first par-1 intron. (Shulman et al., 2000)
Other Comments
	Intragenic recombination at ry is used as an assay of the effects of mutation on meiotic crossing over. (McKim et al., 1998)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_206179 RefSeq (Proteins) • NP_995901 DDBJ / EMBL / GenBank • AA540697 AAC61735 AAF57553 AC004299 AF085276 AQ025035 AQ025763 AQ254816 BI362483 Entrez Gene - A searchable database of RefSeq genes. • 2768853 UniProtKB/TrEMBL • Q7KPA5
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Spo11/DNA topoisomerase VI, subunit A (IPR002815) DNA topoisomerase VI, subunit A (IPR004085)
Linkouts
	BioGRID - A database of protein and genetic interactions • 77703 DroID - A comprehensive database of gene and protein interactions. • FBgn0002716 DRSC - Results from RNAi screens. • FBgn0002716 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0002716 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG30132-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0002716 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 2768853 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 2768853 modMine - Data generated by the modENCODE project. • FBgn0002716
Synonyms & Secondary IDs ( 11 )
Reported As
Symbol Synonym	CG7753 (Keleman et al., 2009.8.5) CG30132   l(2)k05603 (Palmer et al., 1999, ) meiW68 (Huynh and St. Johnston, 2004) mei W-68 (Santos, 1999) mei-W68 (McCaffrey et al., 2006, McKim et al., 2000, Klattenhoff et al., 2007, Garcia et al., 2007, Barbosa et al., 2007, Mehrotra and McKim, 2006, Jang et al., 2003, Joyce and McKim, 2009, Anderson et al., 2009, Wu et al., 2008, Peng and Karpen, 2009, Bozas et al., 2009, Peretz et al., 2009, Joyce et al., 2011, Meyer et al., 2010, Lu et al., 2010, Klattenhoff et al., 2009, Chubykin, 2010) Mei-W68 (Hochwagen, 2006) MeiW68 (Reis et al., 2011) spo11 (Lu et al., 2010) W68 (McKee et al., 2000)
Name Synonym	meiotic W68
Secondary FlyBase IDs
	FBgn0022167 FBgn0050132 FBgn0065111
References ( 93 )
Generate a list of	All references relating to this gene ( 93 )
List References by type	Research paper  ( 44 ) Supplementary material  ( 3 ) Review  ( 13 ) Personal communication to FlyBase  ( 10 ) Abstract  ( 12 ) FlyBase analysis  ( 4 ) Conference report  ( 2 ) Curated genome annotation  ( 3 ) DNA/RNA sequence record  ( 1 ) Letter  ( 1 )
Recent research papers ( 4 )
	Baradaran-Heravi et al., 2012, Hum. Mol. Genet. 21(11): 2572--2587 Penetrance of biallelic SMARCAL1 mutations is associated with environmental and genetic disturbances of gene expression. [FBrf0218299] Joyce et al., 2011, J. Cell Biol. 195(3): 359--367 Drosophila ATM and ATR have distinct activities in the regulation of meiotic DNA damage and repair. [FBrf0216489] Reis et al., 2011, PLoS ONE 6(3): e17512 Drosophila Genes That Affect Meiosis Duration Are among the Meiosis Related Genes That Are More Often Found Duplicated. [FBrf0213266] Takeo et al., 2011, Curr. Biol. 21(21): 1845--1851 Synaptonemal complex-dependent centromeric clustering and the initiation of synapsis in Drosophila oocytes. [FBrf0216635] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2011 Show reviews ...