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Gene Dmel\mago

General Information
Symbol	Dmel\mago	Species	D. melanogaster
Name	mago nashi	Annotation symbol	CG9401
Feature type	protein_coding_gene	FlyBase ID	FBgn0002736
Gene Model Status	Current	Stock availability	4 publicly available
Also Known As	MGN, MAGOH
Genomic Location
Chromosome (arm)	2R	Recombination map
Cytogenetic map	57C2-57C2	Sequence location	2R:17,016,084..17,017,245 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene mago nashi is referred to in FlyBase by the symbol Dmel\mago (CG9401, FBgn0002736). It is a protein_coding_gene from Drosophila melanogaster. Its molecular function is unknown. There is experimental evidence that it is involved in the biological process: protein localization; epidermal growth factor receptor signaling pathway; oocyte microtubule cytoskeleton polarization; regulation of pole plasm oskar mRNA localization; RNA splicing. 23 alleles are reported. The phenotypes of these alleles are annotated with: posterior aeropyle; egg; follicle cell; mesothoracic tergum; micropyle; egg operculum; oocyte nucleus; dorsal appendage. It has one annotated transcript and one annotated polypeptide. Protein features are: Mago nashi protein. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of moderate expression. Peak expression observed within 00-12 hour embryonic stages. Summary of FlyAtlas Anatomical Expression Data: Many larval and adult organs/tissues expressed at moderate levels. Expression at high levels in the following post-embryonic organs or tissues: larval central nervous system, larval salivary gland, adult female reproductive system. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, adult salivary gland, larval trachea, adult male accessory gland, larval/adult carcass. Comments on Affy2 ProbeSet: ProbeSet 1636919_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of mago. Gene sequence location is 2R:17016084..17017245.
External Summaries
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2012_01	Sequence features HFA04703 BKN22681 Controlled Vocabulary Terms exon-exon junction complex
FB2011_10
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 57C2-57C2   Limits computationally determined from genome sequence between P{PZ}king-tubby02821&P{lacW}Xbp1k13803 and P{EP}CG4266EP2258
Experimentally Determined Cytological Location
Cytogenetic map Notes References 57B20-57C2     (Newmark, 1993.11.17)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\mago for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) mago-RA FBtr0071569  NM_057288   1104   147
Additional Transcript Data & Comments
Reported size (kB)	1.1, 0.7 (northern blot) (Newmark and Boswell, 1994)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein mago-PA   FBpp0071497   17.3   147   6.01     NP_476636   AAF46677
Additional Polypeptide Data & Comments
Reported size (kDa)	147 (aa); 17 (kD predicted) (Newmark and Boswell, 1994)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Mago nashi protein (IPR004023) PDB - Protein Data Bank. An information portal to biological macromolecular structures • 1HL6 1OO0
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA203012   AA439711   AE013599 AAF46677   AC004313   AI455086   AY071060 AAL48682   AY231918   AY232121   AY432989   BE978534   BH900873   BI167128   BI167687   BI167742   BI228632   BI229988   BI230435   BI230656   BI236552   BI242569   BI356036   BI367122   BI367637   BI371383   BI371843   BI483125   BI485460   BI632106   BP553833   BP555445   BP556671   BP557009   BP558088   CK134727   CK657370   CO263976   CO285161   CO299652   CO324614   EC198202   EC212190   EV599973   GH752482   GH753421   GH753957   GH757687   GH761397   GH773422   GH791923   GH799077   GH808398   GH809852   GH811119   GH820380   GH836457   GH848364   GH852722   GH859223   GH868781   GH869353   GH870086   GH871191   GH871273   GH878389   GH880324   GH881290   GH891704   GH897468   GH928088   U03559 AAC13746
UniProtKB/Swiss-Prot	P49028
UniProtKB/TrEMBL
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
northern blot Stage Tissue/Position (including subcellular localization) Reference embryonic stage | early   organism | ubiquitous   (Newmark and Boswell, 1994) embryonic stage -- adult stage     (Newmark and Boswell, 1994) adult stage & oogenesis   oocyte   (Newmark and Boswell, 1994) nurse cell   (Newmark and Boswell, 1994)
Additional Descriptive Data
	mago transcripts are expressed throughout development and are present in both adult males and females. They are uniformly expressed throughout the nurse cell-oocyte complex during early oogenesis, are abundant in nurse cells at stage 10, and appear to be uniformly distributed throughout the embryo by the time of egg deposition. (Newmark and Boswell, 1994)
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
epitope tag Stage Tissue/Position (including subcellular localization) Reference adult stage | female & oogenesis stage S9   nurse cell   • nucleus (van Eeden et al., 2001) ring canal | surrounding   (van Eeden et al., 2001) oocyte | posterior   • nucleus (van Eeden et al., 2001) Comment:tightly localized
Additional Descriptive Data
	mago protein is localized to the nuclei of nurse cells in the developing egg chamber. mago also colocalizes with btz in a dense cloud around the ring canals, and at the posterior pole of stage 9 oocytes. (van Eeden et al., 2001)
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0002736    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0002736 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of moderate expression. Peak expression observed within 00-12 hour embryonic stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0002736 expression level Developmental Stage   Expression Level embryo 00-02hr    9338 embryo 02-04hr    14120 embryo 04-06hr    19444 embryo 06-08hr    13788 embryo 08-10hr    13237 embryo 10-12hr    13842 embryo 12-14hr    7885 embryo 14-16hr    6294 embryo 16-18hr    4703 embryo 18-20hr    2575 embryo 20-22hr    3676 embryo 22-24hr    3659 larva L1    3165 larva L2    4423 larva L3 12hr old    3246 larva L3 puffstage 1-2    2623 larva L3 puffstage 3-6    2948 larva L3 puffstage 7-9    4126 white prepupae new    3651 white prepupae 12hr    3416 white prepupae 24hr    4197 pupae 2d postWPP    2076 pupae 3d postWPP    1514 pupae 4d postWPP    1199 adult male 01day    1245 adult male 05day    1361 adult male 30day    1250 adult female 01day    3738 adult female 05day    5938 adult female 30day    6088 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (9338) embryo 02-04hr  (14120) embryo 04-06hr  (19444) embryo 06-08hr  (13788) embryo 08-10hr  (13237) embryo 10-12hr  (13842) embryo 12-14hr  (7885) embryo 14-16hr  (6294) embryo 16-18hr  (4703) embryo 18-20hr  (2575) embryo 20-22hr  (3676) embryo 22-24hr  (3659) larva L1  (3165) larva L2  (4423) larva L3 12hr old  (3246) larva L3 puffstage 1-2  (2623) larva L3 puffstage 3-6  (2948) larva L3 puffstage 7-9  (4126) white prepupae new  (3651) white prepupae 12hr  (3416) white prepupae 24hr  (4197) pupae 2d postWPP  (2076) pupae 3d postWPP  (1514) pupae 4d postWPP  (1199) adult male 01day  (1245) adult male 05day  (1361) adult male 30day  (1250) adult female 01day  (3738) adult female 05day  (5938) adult female 30day  (6088) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (9338) embryo 02-04hr  (14120) embryo 04-06hr  (19444) embryo 06-08hr  (13788) embryo 08-10hr  (13237) embryo 10-12hr  (13842) embryo 12-14hr  (7885) embryo 14-16hr  (6294) embryo 16-18hr  (4703) embryo 18-20hr  (2575) embryo 20-22hr  (3676) embryo 22-24hr  (3659) larva L1  (3165) larva L2  (4423) larva L3 12hr old  (3246) larva L3 puffstage 1-2  (2623) larva L3 puffstage 3-6  (2948) larva L3 puffstage 7-9  (4126) white prepupae new  (3651) white prepupae 12hr  (3416) white prepupae 24hr  (4197) pupae 2d postWPP  (2076) pupae 3d postWPP  (1514) pupae 4d postWPP    1199 adult male 01day    1245 adult male 05day    1361 adult male 30day    1250 adult female 01day  (3738) adult female 05day  (5938) adult female 30day  (6088) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    9338 embryo 02-04hr  (14120) embryo 04-06hr  (19444) embryo 06-08hr  (13788) embryo 08-10hr  (13237) embryo 10-12hr  (13842) embryo 12-14hr    7885 embryo 14-16hr    6294 embryo 16-18hr    4703 embryo 18-20hr    2575 embryo 20-22hr    3676 embryo 22-24hr    3659 larva L1    3165 larva L2    4423 larva L3 12hr old    3246 larva L3 puffstage 1-2    2623 larva L3 puffstage 3-6    2948 larva L3 puffstage 7-9    4126 white prepupae new    3651 white prepupae 12hr    3416 white prepupae 24hr    4197 pupae 2d postWPP    2076 pupae 3d postWPP    1514 pupae 4d postWPP    1199 adult male 01day    1245 adult male 05day    1361 adult male 30day    1250 adult female 01day    3738 adult female 05day    5938 adult female 30day    6088 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    9338 embryo 02-04hr    14120 embryo 04-06hr    19444 embryo 06-08hr    13788 embryo 08-10hr    13237 embryo 10-12hr    13842 embryo 12-14hr    7885 embryo 14-16hr    6294 embryo 16-18hr    4703 embryo 18-20hr    2575 embryo 20-22hr    3676 embryo 22-24hr    3659 larva L1    3165 larva L2    4423 larva L3 12hr old    3246 larva L3 puffstage 1-2    2623 larva L3 puffstage 3-6    2948 larva L3 puffstage 7-9    4126 white prepupae new    3651 white prepupae 12hr    3416 white prepupae 24hr    4197 pupae 2d postWPP    2076 pupae 3d postWPP    1514 pupae 4d postWPP    1199 adult male 01day    1245 adult male 05day    1361 adult male 30day    1250 adult female 01day    3738 adult female 05day    5938 adult female 30day    6088 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0002736 expression level Developmental Stage   Expression Level embryo 00-02hr    9338 embryo 02-04hr    14120 embryo 04-06hr    19444 embryo 06-08hr    13788 embryo 08-10hr    13237 embryo 10-12hr    13842 embryo 12-14hr    7885 embryo 14-16hr    6294 embryo 16-18hr    4703 embryo 18-20hr    2575 embryo 20-22hr    3676 embryo 22-24hr    3659 larva L1    3165 larva L2    4423 larva L3 12hr old    3246 larva L3 puffstage 1-2    2623 larva L3 puffstage 3-6    2948 larva L3 puffstage 7-9    4126 white prepupae new    3651 white prepupae 12hr    3416 white prepupae 24hr    4197 pupae 2d postWPP    2076 pupae 3d postWPP    1514 pupae 4d postWPP    1199 adult male 01day    1245 adult male 05day    1361 adult male 30day    1250 adult female 01day    3738 adult female 05day    5938 adult female 30day    6088 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (9338) embryo 02-04hr  (14120) embryo 04-06hr  (19444) embryo 06-08hr  (13788) embryo 08-10hr  (13237) embryo 10-12hr  (13842) embryo 12-14hr  (7885) embryo 14-16hr  (6294) embryo 16-18hr  (4703) embryo 18-20hr  (2575) embryo 20-22hr  (3676) embryo 22-24hr  (3659) larva L1  (3165) larva L2  (4423) larva L3 12hr old  (3246) larva L3 puffstage 1-2  (2623) larva L3 puffstage 3-6  (2948) larva L3 puffstage 7-9  (4126) white prepupae new  (3651) white prepupae 12hr  (3416) white prepupae 24hr  (4197) pupae 2d postWPP  (2076) pupae 3d postWPP  (1514) pupae 4d postWPP  (1199) adult male 01day  (1245) adult male 05day  (1361) adult male 30day  (1250) adult female 01day  (3738) adult female 05day  (5938) adult female 30day  (6088) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (9338) embryo 02-04hr  (14120) embryo 04-06hr  (19444) embryo 06-08hr  (13788) embryo 08-10hr  (13237) embryo 10-12hr  (13842) embryo 12-14hr  (7885) embryo 14-16hr  (6294) embryo 16-18hr  (4703) embryo 18-20hr  (2575) embryo 20-22hr  (3676) embryo 22-24hr  (3659) larva L1  (3165) larva L2  (4423) larva L3 12hr old  (3246) larva L3 puffstage 1-2  (2623) larva L3 puffstage 3-6  (2948) larva L3 puffstage 7-9  (4126) white prepupae new  (3651) white prepupae 12hr  (3416) white prepupae 24hr  (4197) pupae 2d postWPP  2076 pupae 3d postWPP  1514 pupae 4d postWPP    1199 adult male 01day    1245 adult male 05day    1361 adult male 30day    1250 adult female 01day  (3738) adult female 05day  (5938) adult female 30day  (6088) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    9338 embryo 02-04hr  14120 embryo 04-06hr  19444 embryo 06-08hr  13788 embryo 08-10hr  13237 embryo 10-12hr  13842 embryo 12-14hr    7885 embryo 14-16hr    6294 embryo 16-18hr    4703 embryo 18-20hr    2575 embryo 20-22hr    3676 embryo 22-24hr    3659 larva L1    3165 larva L2    4423 larva L3 12hr old    3246 larva L3 puffstage 1-2    2623 larva L3 puffstage 3-6    2948 larva L3 puffstage 7-9    4126 white prepupae new    3651 white prepupae 12hr    3416 white prepupae 24hr    4197 pupae 2d postWPP    2076 pupae 3d postWPP    1514 pupae 4d postWPP    1199 adult male 01day    1245 adult male 05day    1361 adult male 30day    1250 adult female 01day    3738 adult female 05day    5938 adult female 30day    6088 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    9338 embryo 02-04hr    14120 embryo 04-06hr    19444 embryo 06-08hr    13788 embryo 08-10hr    13237 embryo 10-12hr    13842 embryo 12-14hr    7885 embryo 14-16hr    6294 embryo 16-18hr    4703 embryo 18-20hr    2575 embryo 20-22hr    3676 embryo 22-24hr    3659 larva L1    3165 larva L2    4423 larva L3 12hr old    3246 larva L3 puffstage 1-2    2623 larva L3 puffstage 3-6    2948 larva L3 puffstage 7-9    4126 white prepupae new    3651 white prepupae 12hr    3416 white prepupae 24hr    4197 pupae 2d postWPP    2076 pupae 3d postWPP    1514 pupae 4d postWPP    1199 adult male 01day    1245 adult male 05day    1361 adult male 30day    1250 adult female 01day    3738 adult female 05day    5938 adult female 30day    6088 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0002736    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0002736 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Many larval and adult organs/tissues expressed at moderate levels. Expression at high levels in the following post-embryonic organs or tissues: larval central nervous system, larval salivary gland, adult female reproductive system. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, adult salivary gland, larval trachea, adult male accessory gland, larval/adult carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0002736 expression level Tissue   Expression Level Larval Central Nervous System    1114.15 Larval Midgut    188.2 Larval Hindgut    278.9 Larval Malpighian Tubules    263.1 Larval Fat Body    258.4 Larval Salivary Gland    635.7 Larval Trachea    340.35 Larval Carcass    337.175 Adult Head    140.6 Adult Eye    100.325 Adult Brain    193.1 Adult Thoracic-Abdominal Ganglion    166.3 Adult Crop    240.2 Adult Midgut    164.3 Adult Hindgut    160.8 Adult Malpighian Tubules    175.4 Adult Fat Body    323.2 Adult Salivary Gland    228.5 Adult Heart    132.425 Adult VirginFemale Spermatheca    616.7 Adult InseminatedFemale Spermatheca    520.2 Adult Ovary    760.8 Adult Testis    80 Adult Male Accessory Gland    194.6 Adult Carcass    150.3 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System  (1114.15) Larval Midgut    188.2 Larval Hindgut    278.9 Larval Malpighian Tubules    263.1 Larval Fat Body    258.4 Larval Salivary Gland  (635.7) Larval Trachea    340.35 Larval Carcass    337.175 Adult Head    140.6 Adult Eye    100.325 Adult Brain    193.1 Adult Thoracic-Abdominal Ganglion    166.3 Adult Crop    240.2 Adult Midgut    164.3 Adult Hindgut    160.8 Adult Malpighian Tubules    175.4 Adult Fat Body    323.2 Adult Salivary Gland    228.5 Adult Heart    132.425 Adult VirginFemale Spermatheca  (616.7) Adult InseminatedFemale Spermatheca  520.2 Adult Ovary  (760.8) Adult Testis    80 Adult Male Accessory Gland    194.6 Adult Carcass    150.3 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System  (1114.15) Larval Midgut    188.2 Larval Hindgut    278.9 Larval Malpighian Tubules    263.1 Larval Fat Body    258.4 Larval Salivary Gland    635.7 Larval Trachea    340.35 Larval Carcass    337.175 Adult Head    140.6 Adult Eye    100.325 Adult Brain    193.1 Adult Thoracic-Abdominal Ganglion    166.3 Adult Crop    240.2 Adult Midgut    164.3 Adult Hindgut    160.8 Adult Malpighian Tubules    175.4 Adult Fat Body    323.2 Adult Salivary Gland    228.5 Adult Heart    132.425 Adult VirginFemale Spermatheca    616.7 Adult InseminatedFemale Spermatheca    520.2 Adult Ovary    760.8 Adult Testis    80 Adult Male Accessory Gland    194.6 Adult Carcass    150.3 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    1114.15 Larval Midgut    188.2 Larval Hindgut    278.9 Larval Malpighian Tubules    263.1 Larval Fat Body    258.4 Larval Salivary Gland    635.7 Larval Trachea    340.35 Larval Carcass    337.175 Adult Head    140.6 Adult Eye    100.325 Adult Brain    193.1 Adult Thoracic-Abdominal Ganglion    166.3 Adult Crop    240.2 Adult Midgut    164.3 Adult Hindgut    160.8 Adult Malpighian Tubules    175.4 Adult Fat Body    323.2 Adult Salivary Gland    228.5 Adult Heart    132.425 Adult VirginFemale Spermatheca    616.7 Adult InseminatedFemale Spermatheca    520.2 Adult Ovary    760.8 Adult Testis    80 Adult Male Accessory Gland    194.6 Adult Carcass    150.3 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0002736 expression level Tissue   Expression Level Larval Central Nervous System    1114.15 Larval Midgut    188.2 Larval Hindgut    278.9 Larval Malpighian Tubules    263.1 Larval Fat Body    258.4 Larval Salivary Gland    635.7 Larval Trachea    340.35 Larval Carcass    337.175 Adult Head    140.6 Adult Eye    100.325 Adult Brain    193.1 Adult Thoracic-Abdominal Ganglion    166.3 Adult Crop    240.2 Adult Midgut    164.3 Adult Hindgut    160.8 Adult Malpighian Tubules    175.4 Adult Fat Body    323.2 Adult Salivary Gland    228.5 Adult Heart    132.425 Adult VirginFemale Spermatheca    616.7 Adult InseminatedFemale Spermatheca    520.2 Adult Ovary    760.8 Adult Testis    80 Adult Male Accessory Gland    194.6 Adult Carcass    150.3 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System  (1114.15) Larval Midgut    188.2 Larval Hindgut    278.9 Larval Malpighian Tubules    263.1 Larval Fat Body    258.4 Larval Salivary Gland  635.7 Larval Trachea    340.35 Larval Carcass    337.175 Adult Head    140.6 Adult Eye    100.325 Adult Brain    193.1 Adult Thoracic-Abdominal Ganglion    166.3 Adult Crop    240.2 Adult Midgut    164.3 Adult Hindgut    160.8 Adult Malpighian Tubules    175.4 Adult Fat Body    323.2 Adult Salivary Gland    228.5 Adult Heart    132.425 Adult VirginFemale Spermatheca  616.7 Adult InseminatedFemale Spermatheca  520.2 Adult Ovary  760.8 Adult Testis    80 Adult Male Accessory Gland    194.6 Adult Carcass    150.3 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System  1114.15 Larval Midgut    188.2 Larval Hindgut    278.9 Larval Malpighian Tubules    263.1 Larval Fat Body    258.4 Larval Salivary Gland    635.7 Larval Trachea    340.35 Larval Carcass    337.175 Adult Head    140.6 Adult Eye    100.325 Adult Brain    193.1 Adult Thoracic-Abdominal Ganglion    166.3 Adult Crop    240.2 Adult Midgut    164.3 Adult Hindgut    160.8 Adult Malpighian Tubules    175.4 Adult Fat Body    323.2 Adult Salivary Gland    228.5 Adult Heart    132.425 Adult VirginFemale Spermatheca    616.7 Adult InseminatedFemale Spermatheca    520.2 Adult Ovary    760.8 Adult Testis    80 Adult Male Accessory Gland    194.6 Adult Carcass    150.3 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    1114.15 Larval Midgut    188.2 Larval Hindgut    278.9 Larval Malpighian Tubules    263.1 Larval Fat Body    258.4 Larval Salivary Gland    635.7 Larval Trachea    340.35 Larval Carcass    337.175 Adult Head    140.6 Adult Eye    100.325 Adult Brain    193.1 Adult Thoracic-Abdominal Ganglion    166.3 Adult Crop    240.2 Adult Midgut    164.3 Adult Hindgut    160.8 Adult Malpighian Tubules    175.4 Adult Fat Body    323.2 Adult Salivary Gland    228.5 Adult Heart    132.425 Adult VirginFemale Spermatheca    616.7 Adult InseminatedFemale Spermatheca    520.2 Adult Ovary    760.8 Adult Testis    80 Adult Male Accessory Gland    194.6 Adult Carcass    150.3 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    140.6   NA  Eye    100.325   NA  Brain    193.1   1114.15  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    166.3   NA  Crop    240.2   188.2  Midgut    164.3   278.9  Hindgut    160.8   263.1  Malpighian Tubules    175.4   258.4  Fat Body    323.2   635.7  Salivary Gland    228.5   NA  Heart    132.425   340.35  Trachea    NA   NA  VirginFemale Spermatheca    616.7   NA  InseminatedFemale Spermatheca    520.2   NA  Ovary    760.8   NA  Testis    80   NA  Male Accessory Gland    194.6   337.175  Carcass    150.3 modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_17
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0002736 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG9401-RA FlyExpress - Embryonic expression images (BDGP data) • Show all FlyExpress processed images for mago Stages(s) 1-3 Stages(s) 11-12 Stages(s) 13-16
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal | embryonic stage | maternal effect mago3 lethal | embryonic stage | maternal effect | recessive | heat sensitive mago1 mago2 lethal | maternal effect | recessive | cold sensitive mago1 lethal | recessive mago3 mago69L mago93D mago115F magoRE7 magoSHL1 magoWE7 lethal | recessive | heat sensitive mago1 semi-lethal | pupal stage, with Scer\GAL4pnr-MD237 magoGD12556 viable mago1 mago2 magoETo2 Sterility Allele female sterile | maternal effect | recessive mago1 male sterile | maternal effect | recessive mago1 sterile magoETo2 Other Phenotypes Allele body color defective, with Scer\GAL4pnr-MD237 magoGD12556 cell growth defective magodsRNA.cLa visible, with Scer\GAL4pnr-MD237 magoGD12556 visible | recessive | heat sensitive mago1 wild-type mago+t2.2 magoT:Avic\GFP magoT:Hsap\MYC Phenotype manifest in Allele dorsal appendage mago1 egg mago1 egg | germline clone mago1 mago3 egg chamber | germline clone mago1 egg operculum mago1 follicle cell magounspecified mesothoracic tergum, with Scer\GAL4pnr-MD237 magoGD12556 micropyle mago1 microtubule & egg chamber mago1 microtubule & oocyte mago1 oocyte nucleus mago1 mago2 mago3 oocyte nucleus | germline clone mago1 mago3 posterior aeropyle mago1
Classical Alleles ( 14 )
For All Classical Alleles Show
Allele of mago Class Mutagen Stocks Known lesion magoKG03119 P-element activity 1 -- mago115F 0 Yes mago1 antimorphic allele - genetic evidence, hypomorphic allele - genetic evidence ethyl nitrosourea 0 Yes mago2 antimorphic allele - genetic evidence, hypomorphic allele - genetic evidence ethyl methanesulfonate 0 -- mago3 ethyl methanesulfonate 0 Yes mago69L 0 Yes mago93D 0 Yes magoE19A ethyl nitrosourea 0 Yes magoETo2 ethyl methanesulfonate 0 -- magoRE2 ethyl methanesulfonate 0 Yes magoRE7 ethyl methanesulfonate 0 Yes magoSHL1 ethyl methanesulfonate 0 Yes magounspecified 0 -- magoWE7 ethyl methanesulfonate 0 Yes
Alleles Carried on Transgenic Constructs ( 9 )
For All Alleles Carried on Transgenic Constructs Show
Allele of mago Class Mutagen Stocks Known lesion magoGD12556 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes magoGL00378 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes magoHM05142 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes mago+t2.2 in vitro construct - genomic fragment 0 -- mago1.T:Hsap\MYC in vitro construct - coding region fusion in vitro construct - amino acid replacement in vitro construct - site directed mutagenesis 0 Yes magodsRNA.cLa in vitro construct - RNAi 0 -- magoT:Avic\GFP in vitro construct - coding region fusion 0 Yes magoT:Hsap\MYC in vitro construct - coding region fusion 0 Yes magoαTub67C.T:Avic\GFP in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(2R)AA21 (O'Donnell et al., 1989) Df(2R)Exel6072 (Ryder, 2004.4.26) Df(2R)Exel6073 (Ryder, 2004.4.26) Df(2R)Exel7167 (Ryder, 2004.4.26) Df(2R)F36 (O'Donnell et al., 1989, Newmark and Boswell, 1994) Df(2R)PC18 (O'Donnell et al., 1989) Df(2R)PL3 (O'Donnell et al., 1989, Newmark and Boswell, 1994) Df(2R)Pu-D17 (O'Donnell et al., 1989, Boswell et al., 1991)
Not disrupted in	Df(2R)CC2 (O'Donnell et al., 1989) Df(2R)K11 (O'Donnell et al., 1989) Df(2R)MP1 (O'Donnell et al., 1989) Df(2R)PF1 (O'Donnell et al., 1989) Df(2R)PI12 (O'Donnell et al., 1989) Df(2R)PK1 (O'Donnell et al., 1989)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD12556} NA P{TRiP.GL00378} NA P{TRiP.HM05142} NA characterization construct P{ce-mago} NA P{GFPmago17.1} NA P{GFP-mago} NA P{mago+2.2} NA P{myc-mago} NA P{myc-mago1} NA
Insertions
	Type of insertions Name Expression data miscellaneous insertions P{SUPor-P}magoKG03119 NA
Gene Ontology: Function, Process & Cellular Component ( 22 unique terms )
Terms Based on Experimental Evidence ( 11 terms )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
epidermal growth factor receptor signaling pathway inferred from mutant phenotype (Roignant and Treisman, 2010) oocyte microtubule cytoskeleton polarization inferred from mutant phenotype (Micklem et al., 1997) protein localization inferred from mutant phenotype AND inferred from physical interaction with tsu (Mohr et al., 2001) regulation of pole plasm oskar mRNA localization inferred from mutant phenotype (Micklem et al., 1997) RNA splicing inferred from mutant phenotype (Roignant and Treisman, 2010, Ashton-Beaucage et al., 2010)
Cellular Component
CV term Evidence References
catalytic step 2 spliceosome inferred from direct assay (Herold et al., 2009) cytoplasm inferred from direct assay (Mohr et al., 2001) exon-exon junction complex inferred from physical interaction with tsu (Lewandowski et al., 2010) nucleus inferred from direct assay (Le Hir et al., 2001, Mohr et al., 2001) pole plasm inferred from direct assay (Palacios et al., 2004) precatalytic spliceosome inferred from direct assay (Herold et al., 2009)
Terms Based on Predictions or Assertions ( 15 terms )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
cell-cell signaling non-traceable author statement (Swiss-Prot Project Members, 1996.2.1) maintenance of pole plasm mRNA location traceable author statement (Farina and Singer, 2002) microtubule cytoskeleton organization traceable author statement (Cooperstock and Lipshitz, 1997) mRNA export from nucleus non-traceable author statement (Le Hir et al., 2001) nuclear mRNA splicing, via spliceosome inferred by curator from GO:0071011|GO:0071013 (Herold et al., 2009) oocyte axis specification non-traceable author statement (Swiss-Prot Project Members, 1996.2.1) oocyte microtubule cytoskeleton organization traceable author statement (Johnstone and Lasko, 2001) oocyte microtubule cytoskeleton polarization non-traceable author statement (Swiss-Prot Project Members, 1996.2.1) oogenesis traceable author statement (Cooperstock and Lipshitz, 1997) pole plasm assembly non-traceable author statement (Williamson and Lehmann, 1996) traceable author statement (Wylie, 1999, Mahowald, 2001) pole plasm oskar mRNA localization traceable author statement (Farina and Singer, 2002, Tekotte and Davis, 2002) pole plasm protein localization non-traceable author statement (Swiss-Prot Project Members, 1996.2.1) regulation of pole plasm oskar mRNA localization non-traceable author statement (Mohr et al., 2001, Swiss-Prot Project Members, 1996.2.1)
Cellular Component
CV term Evidence References
nucleus non-traceable author statement (Swiss-Prot Project Members, 1996.2.1) pole plasm non-traceable author statement (Swiss-Prot Project Members, 1996.2.1)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions mago allele Gene References magoETo2 Tm1 (Jankovics et al., 2001) unspecified osk (Jankovics et al., 2001)
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 63039 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0002736 DroID - A comprehensive database of gene and protein interactions. • FBgn0002736 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 37402
Orthologs
Genome-wide drosophilid orthologs	Dana\GF11935 Dere\GG22089 Dgri\GH20720 Dmoj\GI20805 Dper\GL10152 Dpse\GA21763 Dsec\GM15806 Dsim\GD11565 Dvir\GJ20538 Dwil\GK20976 Dyak\mago
Curated drosophilid orthologs	Dpse\GA21763   Dsim\mago (Swanson et al., 2001) Dyak\mago
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL010453-PA Aedes aegypti (mosquito) AAEL011544-PA Aedes aegypti (mosquito) AGAP010755-PA Anopheles gambiae (mosquito) XP_001120074.1 Apis mellifera (honey bee) NP_001119647.1 Acyrthosiphon pisum (pea aphid) At1g02140.1 Arabidopsis thaliana (wall cress) 29761 Batrachochytrium dendrobatidis (chytrid fungus) 114875 Branchiostoma floridae (lancelet) 114879 Branchiostoma floridae (lancelet) BGIBMGA003398-PA Bombyx mori (silk worm) ENSBTAP00000004528 Bos taurus (bovine) ENSBTAP00000025615 Bos taurus (bovine) CN20188 Caenorhabditis brenneri (small nematode) CBP27502 Caenorhabditis briggsae (nematode) CE16310 Caenorhabditis elegans (worm) ENSCAFP00000019796 Canis familiaris (dog) ENSCAFP00000028270 Canis familiaris (dog) ENSCINP00000005510 Ciona intestinalis (sea squirt) JA09942 Caenorhabditis japonica (nematode) cn04514 Cryptococcus neoformans (yeast-like fungus) CPIJ002949 Culex pipens (mosquito) ENSCPOP00000010353 Cavia porcellus (guinea pig) 184322 Chlamidomonas reinhardtii (green alga) RP32432 Caenorhabditis remanei (nematode) 21542 Capitella spl (polychaete worm) DDB0233620 Dictyostelium discoideum (amoeba) 299767 Daphnia pulex (daphnia) ENSDARP00000056404 Danio rerio (zebra fish) ENSECAP00000018245 Equus caballus (horse) XP_651644 Entamoeba histolytica (anaerobic protozoan) ENSGACP00000005087 Gymnopilus aculeatus (mushroom) ENSGALP00000032398 Gallus gallus (chicken) 84829 Hypsipyla robusta (cedar shoot borer) ENSP00000319240 Homo sapiens (human) ENSP00000360525 Homo sapiens (human) ISCW015637-PA Ixodes scapularis (deer tick) 219308 Lottia gigantea (owl limpet) LmjF30.3560 Leishmania major (virus) 32364 Monocosta brevicollis (choanoflagellate) ENSMODP00000000550 Monodelphis domestica (gray opossum) ENSMMUP00000006737 Macaca mulatta (rhesus monkey) ENSMMUP00000009994 Macaca mulatta (rhesus monkey) ENSMUSP00000030348 Mus musculus (house mouse) ENSMUSP00000032307 Mus musculus (house mouse) 200013 Nematostella vectensis (starlet anemone) XP_001608006.1 Nasonia vitripennis (wasp) ENSOANP00000014315 Ornithorynchus anatinus (platypus) ENSORLP00000017122 Oryzias latipes (japanese killifish) LOC_Os12g18880.1 Oryza sativa (asian rice) 31949 Ostreococcus tauri (green alga) MAL7P1.139 Plasmodium falciparum (protozoal parasite) PHUM004847-PA Pediculus humanus (human body louse) PP04384 Pristionchus pacificus (nematode) 109861 Physcomitrella patens (moss) 188860 Physcomitrella patens (moss) ENSPPYP00000001553 Pongo pygmaeus (orangutan) ENSPPYP00000004884 Pongo pygmaeus (orangutan) 95503 Phytophthora ramorum (sudden oak death pathogen) 155630 Phytophthora sojae (root rot pathogen) 740188 Populus trichocarpa (black cottonwood) ENSPTRP00000008006 Pan troglodytes (chimpanzee) PVX_096080 Plasmodium vivax (protozoal parasite) ENSRNOP00000017421 Rattus norvegicus (norway rat) 149230 Sorghum bicolor (sorghum) Smp_103470.3 Schistosoma mansoni (trematode parasite) SPBC3B9.08c Schizosaccharomyces pombe (fission yeast) XP_001176730.1 Strongylocentrotus purpuratus (purple sea urchin) 33631 Trichoplax adhaerens (metazoa) 34543 Trichoplax adhaerens (metazoa) TA07320 Theileria annulata (apicomplexan parasite) XP_967704.1 Tribolium castaneum (red flour beetle) Tc00.1047053506945.200 Trypanosoma cruzi (parasitic trypanosome) ENSTNIP00000009952 Tetraodon nigroviridis (green spotted pufferfish) TP04_0225 Theileria parva (parasitic protozoan) 33806 Thalassiosira pseudonana (marine diatom) ENSTRUP00000042553 Takifugu rubripes (pufferfish Takifugu) ENSXETP00000017688 Xenopus tropicalis (frog) YALI0D26664g Yarrowia lipolytica (nonconventional yeast) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB17105 NV11837 LH10926 ISCW015637 FBgn0067949 FBgn0222968 FBgn0207678 FBgn0183306 FBgn0170722 JGI_V11_299767 FBgn0081748 FBgn0147762 FBgn0143540 FBgn0128183 FBgn0114264 FBgn0088974 CPIJ002949 BGIBMGA003398 ACYPI000063 GB10361 AGAP010755 AAEL011544 AAEL010453 PHUM291670 GLEAN_16112
Stocks & Reagents
Stocks Listed in FlyBase ( 4 )
Bloomington	28931 y1 v1; P{TRiP.HM05142}attP2 35453 y1 sc* v1; P{TRiP.GL00378}attP2 14589 y1; P{SUPor-P}magoKG03119; ry506
VDRC	v28132 w1118; P{GD12556}v28132
Genomic Clones ( 2 )
	BACR12O13 BACR16B07 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 65 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	RE14116
Other clones	DPiM_RE14116 yak-ad_mago yak-em_mago
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	LD03466 LD14346 LD20443 LP23588 RE07446 RE08123 RE08194 RE14375 RE26236 RE27902 RE32623 RE39946 RE42061 RE52813 RE53440 RE58261 RE58850 RE65966 RE68784 RE73641 SD25703
Other clones	13745 66584 bs79a04 Dmel_neb_012229_0880_0536 EK137045 EK168407 EK176053 EK194356 FGM226E07 FGM235C11 FGM304H04 FGM306G10 FGM312H10 RP003009632 RP003024275 RP003063561 RP003086846 RP003101750 RP003102602 RP003146002 RP003170908 RP003229664 RP003240585 RP003249392 RP003250784 RP003260368 RP003278643 RP003279405 RP003286986 RP003377911 RP003386779 RP003417613 RP003419305 RP003432441 RP003466418 RP003505814 RP003588378 RP003617154 RP003654324 RP003673147
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0002736 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 37402
Antibody Information
Other Information
Discoverer
Etymology
	"mago nashi" is Japanese for "without grandchildren". (Newmark and Boswell, 1994)
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of
Additional comments
Other Comments
	mago has a role in the splicing regulation of genes containing long introns. (Ashton-Beaucage et al., 2010) mago has a role in the splicing regulation of heterochromatic genes containing long introns. (Roignant and Treisman, 2010) dsRNA has been made from templates generated with primers directed against this gene. (Roignant et al., 2006) dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology. (Kiger et al., 2003) The mago/tsu physical interaction is conserved, occurs in vitro and in vivo and is not RNA mediated. mago and tsu gene products localize within nuclear speckles. mago/tsu heterodimers associate with spliced mRNAs carrying an exon-exon junction complex. (Le Hir et al., 2001) mago and tsu are required for cell viability. (Le Hir et al., 2001) mago plays two essential roles in Drosophila axis formation: it is required downstream of the signal from the posterior follicle cells for the polarisation of the oocyte microtubule cytoskeleton, and it has a second, independent role in the localisation of osk mRNA to the posterior of the oocyte. (Micklem et al., 1997) mago protein must be localised within the posterior pole plasm for germ-plasm assembly. (Newmark et al., 1997) Distribution of tud protein in mutant embryos has been studied. (Bardsley et al., 1993) mago gene product is a component of the posterior determinative system, required during oogenesis for germ cell determination and delineation of the longitudinal axis of the embryo. (Boswell et al., 1991)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_057288 RefSeq (Proteins) • NP_476636 DDBJ / EMBL / GenBank • AAC13746 AAF46677 AAL48682 AC004313 AY071060 BH900873 BI230435 U03559 Entrez Gene - A searchable database of RefSeq genes. • 37402 UniProtKB/Swiss-Prot • P49028
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Mago nashi protein (IPR004023) PDB - Protein Data Bank. An information portal to biological macromolecular structures • 1HL6 1OO0
Linkouts
	BioGRID - A database of protein and genetic interactions • 63039 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0002736 DroID - A comprehensive database of gene and protein interactions. • FBgn0002736 DRSC - Results from RNAi screens. • FBgn0002736 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0002736 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG9401-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0002736 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 37402 InParanoid A subset of ortholog calls from InParanoid. • AAEL010453-PA Aedes aegypti (mosquito) AAEL011544-PA Aedes aegypti (mosquito) AGAP010755-PA Anopheles gambiae (mosquito) XP_001120074.1 Apis mellifera (honey bee) NP_001119647.1 Acyrthosiphon pisum (pea aphid) At1g02140.1 Arabidopsis thaliana (wall cress) 29761 Batrachochytrium dendrobatidis (chytrid fungus) 114875 Branchiostoma floridae (lancelet) 114879 Branchiostoma floridae (lancelet) BGIBMGA003398-PA Bombyx mori (silk worm) ENSBTAP00000004528 Bos taurus (bovine) ENSBTAP00000025615 Bos taurus (bovine) CN20188 Caenorhabditis brenneri (small nematode) CBP27502 Caenorhabditis briggsae (nematode) CE16310 Caenorhabditis elegans (worm) ENSCAFP00000019796 Canis familiaris (dog) ENSCAFP00000028270 Canis familiaris (dog) ENSCINP00000005510 Ciona intestinalis (sea squirt) JA09942 Caenorhabditis japonica (nematode) cn04514 Cryptococcus neoformans (yeast-like fungus) CPIJ002949 Culex pipens (mosquito) ENSCPOP00000010353 Cavia porcellus (guinea pig) 184322 Chlamidomonas reinhardtii (green alga) RP32432 Caenorhabditis remanei (nematode) 21542 Capitella spl (polychaete worm) DDB0233620 Dictyostelium discoideum (amoeba) 299767 Daphnia pulex (daphnia) ENSDARP00000056404 Danio rerio (zebra fish) ENSECAP00000018245 Equus caballus (horse) XP_651644 Entamoeba histolytica (anaerobic protozoan) ENSGACP00000005087 Gymnopilus aculeatus (mushroom) ENSGALP00000032398 Gallus gallus (chicken) 84829 Hypsipyla robusta (cedar shoot borer) ENSP00000319240 Homo sapiens (human) ENSP00000360525 Homo sapiens (human) ISCW015637-PA Ixodes scapularis (deer tick) 219308 Lottia gigantea (owl limpet) LmjF30.3560 Leishmania major (virus) 32364 Monocosta brevicollis (choanoflagellate) ENSMODP00000000550 Monodelphis domestica (gray opossum) ENSMMUP00000006737 Macaca mulatta (rhesus monkey) ENSMMUP00000009994 Macaca mulatta (rhesus monkey) ENSMUSP00000030348 Mus musculus (house mouse) ENSMUSP00000032307 Mus musculus (house mouse) 200013 Nematostella vectensis (starlet anemone) XP_001608006.1 Nasonia vitripennis (wasp) ENSOANP00000014315 Ornithorynchus anatinus (platypus) ENSORLP00000017122 Oryzias latipes (japanese killifish) LOC_Os12g18880.1 Oryza sativa (asian rice) 31949 Ostreococcus tauri (green alga) MAL7P1.139 Plasmodium falciparum (protozoal parasite) PHUM004847-PA Pediculus humanus (human body louse) PP04384 Pristionchus pacificus (nematode) 109861 Physcomitrella patens (moss) 188860 Physcomitrella patens (moss) ENSPPYP00000001553 Pongo pygmaeus (orangutan) ENSPPYP00000004884 Pongo pygmaeus (orangutan) 95503 Phytophthora ramorum (sudden oak death pathogen) 155630 Phytophthora sojae (root rot pathogen) 740188 Populus trichocarpa (black cottonwood) ENSPTRP00000008006 Pan troglodytes (chimpanzee) PVX_096080 Plasmodium vivax (protozoal parasite) ENSRNOP00000017421 Rattus norvegicus (norway rat) 149230 Sorghum bicolor (sorghum) Smp_103470.3 Schistosoma mansoni (trematode parasite) SPBC3B9.08c Schizosaccharomyces pombe (fission yeast) XP_001176730.1 Strongylocentrotus purpuratus (purple sea urchin) 33631 Trichoplax adhaerens (metazoa) 34543 Trichoplax adhaerens (metazoa) TA07320 Theileria annulata (apicomplexan parasite) XP_967704.1 Tribolium castaneum (red flour beetle) Tc00.1047053506945.200 Trypanosoma cruzi (parasitic trypanosome) ENSTNIP00000009952 Tetraodon nigroviridis (green spotted pufferfish) TP04_0225 Theileria parva (parasitic protozoan) 33806 Thalassiosira pseudonana (marine diatom) ENSTRUP00000042553 Takifugu rubripes (pufferfish Takifugu) ENSXETP00000017688 Xenopus tropicalis (frog) YALI0D26664g Yarrowia lipolytica (nonconventional yeast) Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution • /cytoskel/magonsh1.htm InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 37402 modMine - Data generated by the modENCODE project. • FBgn0002736 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB17105 NV11837 LH10926 ISCW015637 FBgn0067949 FBgn0222968 FBgn0207678 FBgn0183306 FBgn0170722 JGI_V11_299767 FBgn0081748 FBgn0147762 FBgn0143540 FBgn0128183 FBgn0114264 FBgn0088974 CPIJ002949 BGIBMGA003398 ACYPI000063 GB10361 AGAP010755 AAEL011544 AAEL010453 PHUM291670 GLEAN_16112
Synonyms & Secondary IDs ( 15 )
Reported As
Symbol Synonym	CG9401 (Gandhi et al., 2007, Perkins et al., 2009, Herold et al., 2009, Ni et al., 2011.7.19) DmMago (Palacios, 2002) Dm MGN (Le Hir et al., 2001) l(2)57Ca (O'Donnell et al., 1989, ) Mago (Bono et al., 2004, Minakhina and Steward, 2005, Lewandowski et al., 2010, Bono et al., 2010, Saulière et al., 2010) mago (Roignant et al., 2007, Doerflinger et al., 2006, Irion et al., 2006, Zimyanin et al., 2007, Zimyanin et al., 2008, Firth and Baker, 2009, Wang et al., 1994, Baker et al., 2009, Herold et al., 2009, Tuxworth et al., 2009, Roignant and Treisman, 2010, Ashton-Beaucage et al., 2010) MAGOH (Behm-Ansmant and Izaurralde, 2006) Magoh (Le Hir et al., 2003) MGN (Le Hir et al., 2001) mgn (Newmark, 1993.11.17, Foe et al., 1993, Lindsley and Zimm, 1986)
Name Synonym	Mago nashi (Hachet and Ephrussi, 2004, Zimyanin et al., 2008) mago-nashi (Hachet and Ephrussi, 2002, Tuxworth et al., 2009) mago nashi (Tuxworth et al., 2009, Roignant and Treisman, 2010) Mago Nashi (Parma et al., 2007, Nie et al., 2009, Lewandowski et al., 2010) mago nishi (Roignant et al., 2006)
Secondary FlyBase IDs
	FBgn0002095
References ( 112 )
Generate a list of	All references relating to this gene ( 112 )
List References by type	Research paper  ( 47 ) Supplementary material  ( 7 ) Review  ( 38 ) Erratum  ( 1 ) Personal communication to FlyBase  ( 6 ) Abstract  ( 5 ) FlyBase analysis  ( 2 ) DNA/RNA sequence record  ( 1 ) Protein sequence record  ( 1 ) Computer file  ( 2 ) Automatic genome annotation  ( 1 ) Book  ( 1 )
Recent research papers ( 7 )
	Dottorini et al., 2011, BMC Bioinformatics 12: 34 Gepoclu: a software tool for identifying and analyzing gene positional clusters in large-scale gene expression analysis. [FBrf0214379] Ashton-Beaucage et al., 2010, Cell 143(2): 251--262 The exon junction complex controls the splicing of MAPK and other long intron-containing transcripts in Drosophila. [FBrf0212064] Blanco et al., 2010, BMC Dev. Biol. 10: 94 Gene expression following induction of regeneration in Drosophila wing imaginal discs. Expression profile of regenerating wing discs. [FBrf0211812] Bono et al., 2010, Mol. Cell 37(2): 211--222 Nuclear Import Mechanism of the EJC Component Mago-Y14 Revealed by Structural Studies of Importin 13. [FBrf0209868] Lewandowski et al., 2010, Dev. Biol. 339(2): 307--319 Mago Nashi, Tsunagi/Y14, and Ranshi form a complex that influences oocyte differentiation in Drosophila melanogaster. [FBrf0210119] Roignant and Treisman, 2010, Cell 143(2): 238--250 Exon Junction Complex Subunits Are Required to Splice Drosophila MAP Kinase, a Large Heterochromatic Gene. [FBrf0212083] Saulière et al., 2010, Nat. Struct. Mol. Biol. 17(10): 1269--1271 The exon junction complex differentially marks spliced junctions. [FBrf0212018] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2010 Show reviews ...