mgn, l(2)57Ca
novel protein involved in oogenesis - mutation results from the failure of nuclear migration to the anterodorsal cortex during oogenesis - part of the exon junction complex, which is required for post-transcriptional processes such as pre-mRNA splicing, RNA localization and nonsense-mediated decay - involved in germline development, germplasm assembly and photoreceptor differentiation
Please see the JBrowse view of Dmel\mago for information on other features
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Gene model reviewed during 5.51
1.1, 0.7 (northern blot)
There is only one protein coding transcript and one polypeptide associated with this gene
147 (aa); 17 (kD predicted)
Heterodimer with tsu/RBM8A (PubMed:12704080, PubMed:12730685, PubMed:14968132). Part of the mRNA splicing-dependent exon junction complex (EJC) complex; the core complex contains btz/CASC3, eIF4AIII, mago and tsu/RBM8A (PubMed:14973490). Interacts with Pym (via N-terminus); the interaction is direct (PubMed:24967911, PubMed:14968132). Interacts with eIF4AIII (PubMed:14973490).
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\mago using the Feature Mapper tool.
Comment: maternally deposited
Comment: reported as procephalic ectoderm anlage
Comment: reported as procephalic ectoderm anlage
Comment: reported as procephalic ectoderm anlage
Comment: reported as procephalic ectoderm anlage
Comment: reported as procephalic ectoderm primordium
Comment: reported as procephalic ectoderm primordium
Comment: reported as procephalic ectoderm primordium
Comment: reported as procephalic ectoderm primordium
Comment: reported as procephalic ectoderm primordium
Comment: reported as procephalic ectoderm primordium
mago transcripts are expressed throughout development and are present in both adult males and females. They are uniformly expressed throughout the nurse cell-oocyte complex during early oogenesis, are abundant in nurse cells at stage 10, and appear to be uniformly distributed throughout the embryo by the time of egg deposition.
GBrowse - Visual display of RNA-Seq signals
View Dmel\mago in GBrowse 22-93
2-93
2-100.3
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
polyclonal
mago has a role in the splicing regulation of genes containing long introns.
mago has a role in the splicing regulation of heterochromatic genes containing long introns.
mago is required for female germline stem cell differentiation.
dsRNA has been made from templates generated with primers directed against this gene.
dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology.
mago protein must be localised within the posterior pole plasm for germ-plasm assembly.
Distribution of tud protein in mutant embryos has been studied.
mago gene product is a component of the posterior determinative system, required during oogenesis for germ cell determination and delineation of the longitudinal axis of the embryo.
"mago nashi" is Japanese for "without grandchildren".