Gene Dmel\mgr

Help

Close All Open All

General Information

Symbol

Dmel\mgr

Species

D. melanogaster

Name

merry-go-round

Annotation symbol

Feature type

gene

FlyBase ID

FBgn0002738

Gene Model Status

Unannotated

Stock availability

None publicly available

Genomic Location

Chromosome (arm)

Recombination map

3-51.3

Cytogenetic map

86E3-86E10

Sequence location

Summary Information

Automatically generated summary

See sections below for more information

The gene merry-go-round is referred to in FlyBase by the symbol Dmel\mgr (FBgn0002738). It is a gene from Drosophila melanogaster. Its molecular function is unknown. The biological processes in which it is involved are not known. 3 alleles are reported. The phenotypes of these alleles are annotated with: germline cyst; mitotic cell cycle; macrochaeta; wing; embryonic/larval brain. It has no annotated transcripts. Gene has not been localized to the genome sequence.

Phenotypic Description from the Red Book (Lindsley & Zimm 1992)

Gene/Allele symbols may differ from current usage

mgr: merry-go-round

Most characteristic abnormality is appearance of mitotic and meiotic figures in which all the chromosomes are arranged in a circle. Other mutant traits include metaphase arrest, polyploid cells, postmeiotic cysts with 16 nuclei, and spermatids carrying four times the normal complement of chromosomes. The circular mitotic figures (CMF's) are caused by monopolar spindles. The wild-type allele of mgr apparently is necessary for correct centrosome behavior.

Recent Updates

Description

What does this section display?

This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms).

What does this section not display?

This section does not currently display links that were removed or gene model changes.

Update Feed

Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.

FB2012_01

FB2011_10

All updates

Click here to see a list of all updates to this record from FB2010_08 and on.

Detailed Mapping Data

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

86E3-86E10

Left limit from inclusion within Df(3R)T-61 (citation unavailable)

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

Experimentally Determined Recombination Data

Location

3-51.3

3-51.1

(Ripoll et al., 1987)

Left of (cM)

Right of (cM)

Notes

Gene Model & Products

Comments on Gene Model

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Associated CDS (aa)

Additional Transcript Data & Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

RefSeq ID

GenBank protein

Additional Polypeptide Data & Comments

Reported size (kDa)

Comments

External Data

Linkouts

Crossreferences

Sequences Consistent with the Gene Model

DDBJ /
EMBL /
GenBank

DNA sequence

Protein sequence

Name

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Mapped Features

Type

Symbol & Location

Additional Notes

References

External Data

Linkouts

Crossreferences

Expression Data

Transcript Expression

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Notes

Polypeptide Expression

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Notes

High-Throughput Expression Data

Expression Clusters

External Data & Images

Linkouts

Alleles & Phenotypes

Summary of Allele Phenotypes

Lethality

Allele

viable

mgr^DD1

Sterility

Allele

male sterile

mgr^DD1

sterile

mgr^DD1

Other Phenotypes

Allele

mitotic cell cycle defective

mgr¹

visible

mgr^DD1

Phenotype manifest in

Allele

embryonic/larval brain

mgr^DD1

germline cyst

mgr^DD1

macrochaeta

mgr^DD1

mitotic cell cycle

mgr^unspecified

wing

mgr^DD1

wing | male

mgr^DD1

Classical Alleles ( 3 )

For All Classical Alleles Show

Allele of mgr	Class	Mutagen	Known lesion
mgr¹	hypomorphic allele - genetic evidence	X ray	--
mgr^DD1		ethyl methanesulfonate	--
mgr^unspecified			--

Alleles Carried on Transgenic Constructs ( 0 )

For All Alleles Carried on Transgenic Constructs Show

Allele of mgr	Class	Mutagen	Stocks	Known lesion

Aneuploid Aberrations

Transgenic Constructs & Insertions

Transgenic Constructs

Type of construct

Name

Expression data

Insertions

Type of insertions

Name

Expression data

Gene Ontology: Function, Process & Cellular Component ( 0 unique terms )

Terms Based on Experimental Evidence ( 0 terms )

Terms Based on Predictions or Assertions ( 0 terms )

Sequence Ontology: Class of Gene

gene

Interactions & Pathways

Summary of Physical Interactions

Protein-protein

Interacting group

Assay

References

Summary of Genetic Interactions

Interacts with

Please look at the allele data for full details of the genetic interactions

mgr allele

Gene

References

unspecified

asp

(Ripoll et al., 1987)

External Data

Linkouts

DroID - A comprehensive database of gene and protein interactions.

•

FBgn0002738

Orthologs

Genome-wide drosophilid orthologs

Curated drosophilid orthologs

Linkouts

Stocks & Reagents

Stocks Listed in FlyBase ( 0 )

Genomic Clones ( 0 )

cDNA Clones ( 0 )

cDNA Clones, Fully Sequenced

BDGP DGC clones

Other clones

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi & Array Information

Linkouts

GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents

•

47175

Antibody Information

Other Information

Discoverer

Etymology

Identification

Relationship to Other Genes

Source for database identity of

Source for database merge of

Additional comments

Other Comments

Five genes essential for cell cycle progression, polo, mgr, asp, stg and gnu, are recombined onto a single chromosome, EMS mutations are isolated that fail to complement this chromosome. Genes encoding proteins that interact with the products of any of the five genes are isolated.

(White-Cooper et al., 1996)

The neuroblast phenotype of aur mutants is similar to that of mgr mutants.

(Glover, 1995)

External Crossreferences & Linkouts

Sequence Crossreferences

Other Crossreferences

Linkouts

DroID - A comprehensive database of gene and protein interactions.

•

FBgn0002738

GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents

•

47175

Synonyms & Secondary IDs ( 2 )

Reported As

Symbol Synonym

mgr

(Garcia et al., 2007)

Name Synonym

merry-go-round

(Ripoll et al., 1987, Garcia et al., 2007)

Secondary FlyBase IDs

References ( 18 )

Research paper

Gonzalez et al., 1998, Chromosoma 107(6-7): 452--460: Interactions between mgr, asp, and polo: asp function modulated by polo and needed to maintain the poles of monopolar and bipolar spindles. [FBrf0106553]
Inoue and Glover, 1998, Molec. gen. Genet. 258(4): 334--341: Involvement of the rolled/MAP kinase gene in Drosophila mitosis: interaction between genes of the MAP kinase cascade and abnormal spindle. [FBrf0102574]
Deak et al., 1997, Genetics 147(4): 1697--1722: P-element insertion alleles of essential genes on the third chromosome of Drosophila melanogaster: correlation of physical and cytogenetic maps in chromosomal region 86E-87F. [FBrf0099762]
White-Cooper et al., 1996, Genetics 144(3): 1097--1111: Mutations in new cell cycle genes that fail to complement a multiply mutant third chromosome of Drosophila. [FBrf0090856]
Glover et al., 1995, Cell 81(1): 95--105: Mutations in aurora prevent centrosome separation leading to the formation of monopolar spindles. [FBrf0080055]
Gatti and Goldberg, 1991, Methods Cell Biol. 35: 543--586: Mutations affecting cell division in Drosophila. [FBrf0054636]
Gonzalez et al., 1988, J. Cell Sci. 89: 39--47: Functional monopolar spindles caused by mutation in mgr, a cell division gene of Drosophila melanogaster. [FBrf0048436]

Review

Kline-Smith and Walczak, 2000, J. Cell Biol. 149(1): 5--6: Microtubules in orbit. [FBrf0126827]
Gonzalez et al., 1998, J. Cell Sci. 111(18): 2697--2706: Centrosomes and microtubule organisation during Drosophila development. [FBrf0105232]
Foe et al., 1993, Bate, Martinez Arias, 1993: 149--300: Mitosis and morphogenesis in the Drosophila embryo: Point and counterpoint. [FBrf0064779]
Fuller, 1993, Bate, Martinez Arias, 1993: 71--147: Spermatogenesis. [FBrf0064778]
Glover, 1990, Curr. Opin. Cell Biol. 2(2): 258--261: Abbreviated and regulated cell cycles in Drosophila. [FBrf0051484]
Ripoll et al., 1987, BioEssays 7: 204--210: Towards the genetic dissection of mitosis in Drosophila. [FBrf0045682]

Abstract

Fedorova et al., 1997, Europ. Dros. Res. Conf. 15: 98: Insertion mutant V40 causing centrosome non disjunction. [FBrf0098663]
Glover, 1995, Europ. Dros. Res. Conf. 14: 39: The centrosome cycle in Drosophila: its regulation and conservation. [FBrf0083153]
White-Cooper et al., 1995, Molec. Biol. Cell 6(Suppl.): 132a: Novel mutations that interact with a set of mitotic mutants in Drosophila. [FBrf0086141]

Conference report

Garcia et al., 2007, Fly 1(2): 125--131: Cell cycle regulation. [FBrf0200076]

Book

Lindsley and Zimm, 1992, The Genome of Drosophila melanogaster.: The Genome of Drosophila melanogaster. [FBrf0066905]