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Gene Dmel\msl-3

General Information
Symbol	Dmel\msl-3	Species	D. melanogaster
Name	male-specific lethal 3	Annotation symbol	CG8631
Feature type	protein_coding_gene	FlyBase ID	FBgn0002775
Gene Model Status	Current	Stock availability	7 publicly available
Also Known As	msl3, msl, mle3
Genomic Location
Chromosome (arm)	3L	Recombination map	3-25.8
Cytogenetic map	65E4-65E4	Sequence location	3L:7,116,310..7,118,623 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene male-specific lethal 3 is referred to in FlyBase by the symbol Dmel\msl-3 (CG8631, FBgn0002775). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: chromatin binding; methylated histone residue binding. There is experimental evidence that it is involved in the biological process: dosage compensation. 33 alleles are reported. No phenotypic data is available. It has 2 annotated transcripts and 2 annotated polypeptides. Protein features are: Chromo domain-like; Chromo domain/shadow; MRG. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of low expression. Peak expression observed within 00-06 hour embryonic stages. Summary of FlyAtlas Anatomical Expression Data: Two or more Affy2 ProbeSets identify exons of this gene. This is a summary of the tissue expression peaks exhibited in at least one of these ProbeSets. Expression at moderate levels in the following post-embryonic organs or tissues: larval central nervous system, adult crop, adult hindgut, adult salivary gland, adult ovary, larval carcass. Gene sequence location is 3L:7116310..7118623.
External Summaries
Phenotypic Description from the Red Book (Lindsley & Zimm 1992)
Gene/Allele symbols may differ from current usage	mle3 Homozygous males exhibit delayed development; survive as larvae for ten days. Ten-day-old male larvae have small undeveloped imaginal discs, which, however, when transplanted into wild type larvae are capable of undergoing nearly complete (wing, leg) or partial (eye-antenna) differentiation; few homozygous mle gynandromorphs survive; XO patches small, with small bristles, and mostly confined to abdomen [Uenoyama, Uchida, Fukunaga, and Oishi, 1982, Genetics 102: 223-31(fig.)]. No interaction with mle. Females transformed into phenotypic males (tra, tra2) or intersexes (dsx) unaffected by mle3, i.e. mle3 acts only upon single-X-bearing flies. Females heterozygous for SxlF1 and homozygous (and to a lesser extent heterozygous) for mle3 show signs of intersexual development; effect less severe when mothers homozygous for mle3 [Uenoyama, Fukunaga, and Oishi, 1982, Genetics 102: 233-43 (fig.)]. Staining of polytene X chromosome of mle3 males similar to that of mle males (Lucchesi, Skripsky, and Tax, 1982, Genetics 100: s42; Okuno, Satou, and Oishi, 1984, Jpn. J. Genet. 59: 237-47).
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2011_10
FB2012_01	Controlled Vocabulary Terms methylated histone residue binding Alleles msl-3[EPAA.T:Zzzz\TAP] msl-3[Y31A.T:Zzzz\TAP] msl-3[WT.T:Zzzz\TAP] Transgenic Constructs P{msl-3.TAP.Y31A} P{msl-3.TAP.EPAA} P{msl-3.TAP.WT} Sequence features BKN22084 HFA11371 References Schiemann et al., 2010, Biochem. Biophys. Res. Commun. 402(4): 699--704 Gorchakov et al., 2010, Genetika, Moscow 46(10): 1430--1434
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 65E4-65E4   Limits computationally determined from genome sequence between P{lacW}l(3)L4060L4060 and P{PZ}corn04202
Experimentally Determined Cytological Location
Cytogenetic map Notes References 65D-65E     (Franke, 1994.9.3)
Experimentally Determined Recombination Data
Location	3-25.8
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\msl-3 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) msl-3-RA FBtr0076926  NM_079227   1963   512 msl-3-RB FBtr0076927  NM_168191   1776   481
Additional Transcript Data & Comments
Reported size (kB)	1.8 (longest cDNA) (Gorman et al., 1995)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein msl-3-PA   FBpp0076635   58.9   512   7.21     NP_523951   AAF50612 msl-3-PB   FBpp0076636   55.2   481   7.19     NP_729213   AAN12073
Additional Polypeptide Data & Comments
Reported size (kDa)	512, 481 (aa); 58 (kD observed); 57, 53 (kD predicted) (Gorman et al., 1995)
Comments	The putative 481aa msl-3 protein is predicted from the sequence of one cDNA which represents a transcript generated by alternative splicing. The encoded protein has three unique amino-terminal amino acids and is colinear with the longer msl-3 protein from amino acid 35 of the 512aa protein on. A protein of the expected size has not been detected in larvae by western blots. (Gorman et al., 1995) Antibodies were made to regions common to both of the predicted msl-3 proteins. (Gorman et al., 1995)
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Chromo domain/shadow (IPR000953) MRG (IPR008676) Chromo domain-like (IPR016197)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA538905   AA950345   AA978495   AA990785   AE014296 AAF50612   AE014296 AAN12073   AI513877   AI515531   AI543994   AQ073780   AY071074 AAL48696   BH614844   BI166072   BI172248   BI173256   BI236251   BI366752   BI484053   BI486654   CO309310   CO319611   EC204492   EC247716   EC250299   GH750442   GH759745   GH759917   GH771047   GH782916   GH786431   GH788443   GH789665   GH807965   GH809467   GH819128   GH820259   GH825627   GH829681   GH829728   GH829980   GH832951   GH833579   GH835435   GH843728   GH844466   GH850002   GH856669   GH860286   GH867244   GH877420   GH877715   GH884735   GH890253   GH899414   GH899793   GH902850   GH906694   GH917807   GH919733   GH923037   GH928076   GH932327   GH942386   X81321 CAA57101
UniProtKB/Swiss-Prot	P50536
UniProtKB/TrEMBL
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
western blot Stage Tissue/Position (including subcellular localization) Reference larval stage | male     (Gorman et al., 1995) larval stage | female     (Gorman et al., 1995)
Additional Descriptive Data
	msl-3 protein is present in male and female larvae but is much less abundant in females. (Gorman et al., 1995)
Marker for
Subcellular Localization
CV Term	polytene chromosome (Gorman et al., 1995)
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0002775    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0002775 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of low expression. Peak expression observed within 00-06 hour embryonic stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0002775 expression level Developmental Stage   Expression Level embryo 00-02hr    4223 embryo 02-04hr    2756 embryo 04-06hr    3434 embryo 06-08hr    2744 embryo 08-10hr    2494 embryo 10-12hr    1997 embryo 12-14hr    1488 embryo 14-16hr    1529 embryo 16-18hr    1269 embryo 18-20hr    881 embryo 20-22hr    1427 embryo 22-24hr    1316 larva L1    715 larva L2    438 larva L3 12hr old    355 larva L3 puffstage 1-2    499 larva L3 puffstage 3-6    693 larva L3 puffstage 7-9    740 white prepupae new    713 white prepupae 12hr    911 white prepupae 24hr    1063 pupae 2d postWPP    798 pupae 3d postWPP    508 pupae 4d postWPP    401 adult male 01day    577 adult male 05day    729 adult male 30day    677 adult female 01day    1002 adult female 05day    1771 adult female 30day    1864 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (4223) embryo 02-04hr  (2756) embryo 04-06hr  (3434) embryo 06-08hr  (2744) embryo 08-10hr  (2494) embryo 10-12hr  (1997) embryo 12-14hr  (1488) embryo 14-16hr  (1529) embryo 16-18hr  (1269) embryo 18-20hr  (881) embryo 20-22hr  (1427) embryo 22-24hr  (1316) larva L1  (715) larva L2  (438) larva L3 12hr old  (355) larva L3 puffstage 1-2  (499) larva L3 puffstage 3-6  (693) larva L3 puffstage 7-9  (740) white prepupae new  (713) white prepupae 12hr  (911) white prepupae 24hr  (1063) pupae 2d postWPP  (798) pupae 3d postWPP  (508) pupae 4d postWPP  (401) adult male 01day  (577) adult male 05day  (729) adult male 30day  (677) adult female 01day  (1002) adult female 05day  (1771) adult female 30day  (1864) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (4223) embryo 02-04hr  (2756) embryo 04-06hr  (3434) embryo 06-08hr  (2744) embryo 08-10hr  (2494) embryo 10-12hr  (1997) embryo 12-14hr  1488 embryo 14-16hr  (1529) embryo 16-18hr    1269 embryo 18-20hr    881 embryo 20-22hr  1427 embryo 22-24hr    1316 larva L1    715 larva L2    438 larva L3 12hr old    355 larva L3 puffstage 1-2    499 larva L3 puffstage 3-6    693 larva L3 puffstage 7-9    740 white prepupae new    713 white prepupae 12hr    911 white prepupae 24hr    1063 pupae 2d postWPP    798 pupae 3d postWPP    508 pupae 4d postWPP    401 adult male 01day    577 adult male 05day    729 adult male 30day    677 adult female 01day    1002 adult female 05day  (1771) adult female 30day  (1864) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    4223 embryo 02-04hr    2756 embryo 04-06hr    3434 embryo 06-08hr    2744 embryo 08-10hr    2494 embryo 10-12hr    1997 embryo 12-14hr    1488 embryo 14-16hr    1529 embryo 16-18hr    1269 embryo 18-20hr    881 embryo 20-22hr    1427 embryo 22-24hr    1316 larva L1    715 larva L2    438 larva L3 12hr old    355 larva L3 puffstage 1-2    499 larva L3 puffstage 3-6    693 larva L3 puffstage 7-9    740 white prepupae new    713 white prepupae 12hr    911 white prepupae 24hr    1063 pupae 2d postWPP    798 pupae 3d postWPP    508 pupae 4d postWPP    401 adult male 01day    577 adult male 05day    729 adult male 30day    677 adult female 01day    1002 adult female 05day    1771 adult female 30day    1864 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    4223 embryo 02-04hr    2756 embryo 04-06hr    3434 embryo 06-08hr    2744 embryo 08-10hr    2494 embryo 10-12hr    1997 embryo 12-14hr    1488 embryo 14-16hr    1529 embryo 16-18hr    1269 embryo 18-20hr    881 embryo 20-22hr    1427 embryo 22-24hr    1316 larva L1    715 larva L2    438 larva L3 12hr old    355 larva L3 puffstage 1-2    499 larva L3 puffstage 3-6    693 larva L3 puffstage 7-9    740 white prepupae new    713 white prepupae 12hr    911 white prepupae 24hr    1063 pupae 2d postWPP    798 pupae 3d postWPP    508 pupae 4d postWPP    401 adult male 01day    577 adult male 05day    729 adult male 30day    677 adult female 01day    1002 adult female 05day    1771 adult female 30day    1864 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0002775 expression level Developmental Stage   Expression Level embryo 00-02hr    4223 embryo 02-04hr    2756 embryo 04-06hr    3434 embryo 06-08hr    2744 embryo 08-10hr    2494 embryo 10-12hr    1997 embryo 12-14hr    1488 embryo 14-16hr    1529 embryo 16-18hr    1269 embryo 18-20hr    881 embryo 20-22hr    1427 embryo 22-24hr    1316 larva L1    715 larva L2    438 larva L3 12hr old    355 larva L3 puffstage 1-2    499 larva L3 puffstage 3-6    693 larva L3 puffstage 7-9    740 white prepupae new    713 white prepupae 12hr    911 white prepupae 24hr    1063 pupae 2d postWPP    798 pupae 3d postWPP    508 pupae 4d postWPP    401 adult male 01day    577 adult male 05day    729 adult male 30day    677 adult female 01day    1002 adult female 05day    1771 adult female 30day    1864 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (4223) embryo 02-04hr  (2756) embryo 04-06hr  (3434) embryo 06-08hr  (2744) embryo 08-10hr  (2494) embryo 10-12hr  (1997) embryo 12-14hr  (1488) embryo 14-16hr  (1529) embryo 16-18hr  (1269) embryo 18-20hr  (881) embryo 20-22hr  (1427) embryo 22-24hr  (1316) larva L1  (715) larva L2  (438) larva L3 12hr old  (355) larva L3 puffstage 1-2  (499) larva L3 puffstage 3-6  (693) larva L3 puffstage 7-9  (740) white prepupae new  (713) white prepupae 12hr  (911) white prepupae 24hr  (1063) pupae 2d postWPP  (798) pupae 3d postWPP  (508) pupae 4d postWPP  (401) adult male 01day  (577) adult male 05day  (729) adult male 30day  (677) adult female 01day  (1002) adult female 05day  (1771) adult female 30day  (1864) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (4223) embryo 02-04hr  (2756) embryo 04-06hr  (3434) embryo 06-08hr  (2744) embryo 08-10hr  (2494) embryo 10-12hr  1997 embryo 12-14hr  1488 embryo 14-16hr  1529 embryo 16-18hr    1269 embryo 18-20hr    881 embryo 20-22hr  1427 embryo 22-24hr    1316 larva L1    715 larva L2    438 larva L3 12hr old    355 larva L3 puffstage 1-2    499 larva L3 puffstage 3-6    693 larva L3 puffstage 7-9    740 white prepupae new    713 white prepupae 12hr    911 white prepupae 24hr    1063 pupae 2d postWPP    798 pupae 3d postWPP    508 pupae 4d postWPP    401 adult male 01day    577 adult male 05day    729 adult male 30day    677 adult female 01day    1002 adult female 05day  1771 adult female 30day  1864 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    4223 embryo 02-04hr    2756 embryo 04-06hr    3434 embryo 06-08hr    2744 embryo 08-10hr    2494 embryo 10-12hr    1997 embryo 12-14hr    1488 embryo 14-16hr    1529 embryo 16-18hr    1269 embryo 18-20hr    881 embryo 20-22hr    1427 embryo 22-24hr    1316 larva L1    715 larva L2    438 larva L3 12hr old    355 larva L3 puffstage 1-2    499 larva L3 puffstage 3-6    693 larva L3 puffstage 7-9    740 white prepupae new    713 white prepupae 12hr    911 white prepupae 24hr    1063 pupae 2d postWPP    798 pupae 3d postWPP    508 pupae 4d postWPP    401 adult male 01day    577 adult male 05day    729 adult male 30day    677 adult female 01day    1002 adult female 05day    1771 adult female 30day    1864 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    4223 embryo 02-04hr    2756 embryo 04-06hr    3434 embryo 06-08hr    2744 embryo 08-10hr    2494 embryo 10-12hr    1997 embryo 12-14hr    1488 embryo 14-16hr    1529 embryo 16-18hr    1269 embryo 18-20hr    881 embryo 20-22hr    1427 embryo 22-24hr    1316 larva L1    715 larva L2    438 larva L3 12hr old    355 larva L3 puffstage 1-2    499 larva L3 puffstage 3-6    693 larva L3 puffstage 7-9    740 white prepupae new    713 white prepupae 12hr    911 white prepupae 24hr    1063 pupae 2d postWPP    798 pupae 3d postWPP    508 pupae 4d postWPP    401 adult male 01day    577 adult male 05day    729 adult male 30day    677 adult female 01day    1002 adult female 05day    1771 adult female 30day    1864 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0002775    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0002775 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Two or more Affy2 ProbeSets identify exons of this gene. This is a summary of the tissue expression peaks exhibited in at least one of these ProbeSets. Expression at moderate levels in the following post-embryonic organs or tissues: larval central nervous system, adult crop, adult hindgut, adult salivary gland, adult ovary, larval carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Heatmap Tissue   Expression Level Larval Central Nervous System no informative data Larval Midgut no informative data Larval Hindgut no informative data Larval Malpighian Tubules no informative data Larval Fat Body no informative data Larval Salivary Gland no informative data Larval Trachea no informative data Larval Carcass no informative data Adult Head no informative data Adult Eye no informative data Adult Brain no informative data Adult Thoracic-Abdominal Ganglion no informative data Adult Crop no informative data Adult Midgut no informative data Adult Hindgut no informative data Adult Malpighian Tubules no informative data Adult Fat Body no informative data Adult Salivary Gland no informative data Adult Heart no informative data Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca no informative data Adult Ovary no informative data Adult Testis no informative data Adult Male Accessory Gland no informative data Adult Carcass no informative data modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_17
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0002775 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG8631-RB;CG8631-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal | larval stage | male msl-31 msl-3MAK lethal | male msl-31 msl-32 msl-33 lethal | male | recessive msl-31 msl-33 msl-3unspecified viable, with Scer\GAL4pnr-MD237 msl-3GD1492 Other Phenotypes Allele visible | male limited | somatic clone msl-3083 wild-type msl-3+tC msl-3+tD msl-3+tE Phenotype manifest in Allele eye | male limited | somatic clone msl-3083
Classical Alleles ( 10 )
For All Classical Alleles Show
Allele of msl-3 Class Mutagen Stocks Known lesion msl-31 spontaneous 1 -- msl-3EP3144 P-element activity 1 -- msl-3G3761 P-element activity 1 -- msl-3KG00939 P-element activity 1 -- msl-3MB11711 1 -- msl-3083 0 Yes msl-32 ethyl methanesulfonate 0 -- msl-33 ethyl methanesulfonate 0 -- msl-3MAK X ray 0 -- msl-3unspecified 0 --
Alleles Carried on Transgenic Constructs ( 23 )
For All Alleles Carried on Transgenic Constructs Show
Allele of msl-3 Class Mutagen Stocks Known lesion msl-3GD1492 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes msl-3GL00170 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes msl-3+tC in vitro construct - genomic fragment 0 -- msl-3+tD in vitro construct - genomic fragment 0 -- msl-3+tE in vitro construct - genomic fragment 0 -- msl-3Act5C.T:Zzzz\FLAG in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes msl-3dsRNA.cBa in vitro construct - RNAi 0 Yes msl-3EPAA.T:Zzzz\TAP in vitro construct - amino acid replacement 0 Yes msl-3F56A.tub.T:Avic\GFP-EGFP in vitro construct - regulatory fusion in vitro construct - coding region fusion in vitro construct - amino acid replacement 0 Yes msl-3hs.PS in vitro construct - regulatory fusion 0 Yes msl-3hs.T:Avic\GFP-EGFP in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes msl-3hs.T:Ivir\HA1 in vitro construct - coding region fusion 0 Yes msl-3K116G.tub.T:Zzzz\FLAG in vitro construct - regulatory fusion in vitro construct - coding region fusion in vitro construct - amino acid replacement 0 Yes msl-3MRG.hs.T:Avic\GFP-EGFP in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes msl-3MtnA.T:Zzzz\FLAG in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes msl-3T:Zzzz\TAP in vitro construct - coding region fusion 0 Yes msl-3tub.T:Avic\GFP-EGFP in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes msl-3tub.T:Zzzz\FLAG in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes msl-3WT.T:Zzzz\TAP in vitro construct - coding region fusion 0 Yes msl-3Y31A.T:Zzzz\TAP in vitro construct - amino acid replacement 0 Yes msl-3ΔCBD.hs.T:Avic\GFP-EGFP in vitro construct - regulatory fusion in vitro construct - coding region fusion in vitro construct - deletion 0 Yes msl-3ΔMRG.hs.T:Avic\GFP-EGFP in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes msl-3ΔPOLAR.hs.T:Avic\GFP-EGFP in vitro construct - regulatory fusion in vitro construct - coding region fusion in vitro construct - deletion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(3L)BSC27 (Deal et al., 2002.12.17) Df(3L)Exel6110 (Ryder, 2004.4.26) Ts(Y;3Lt)B234+Ts(Y;3Rt)B186 (Gorman et al., 1995) Ts(Y;3Lt)P50+Ts(Y;3Rt)B186 (Gorman et al., 1995)
Duplicated in	Ts(Y;3Lt)G130 (Gorman et al., 1995) Ts(Y;3Lt)H138 (Gorman et al., 1995)
Not duplicated in	Ts(Y;3Lt)G43 (Gorman et al., 1995) Ts(Y;3Lt)P50 (Gorman et al., 1995) Ts(YSt;3Lt)A158 (Gorman et al., 1995) Ts(YSt;3Lt)B234 (Gorman et al., 1995)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD1492} NA P{TRiP.GL00170} NA heat-shock construct P{hs-msl-3.EGFP} NA P{hs-msl-3.HA} NA P{hs-msl-3.MRG.EGFP} NA P{hs-msl-3.ΔCBD.EGFP} NA P{hs-msl-3.ΔMRG.EGFP} NA P{hs-msl-3.ΔPOLAR.EGFP} NA P{hs-msl-3} NA characterization construct P{msl-3.TAP.EPAA} NA P{msl-3.TAP.WT} NA P{msl-3.TAP.Y31A} NA P{msl-3.TAP} NA P{msl-3+C} NA P{msl-3+D} NA P{msl-3+E} NA P{tub-msl-3.EGFP} NA P{tub-msl-3.F56A.EGFP} NA P{tub-msl-3.K116G.FLAG} NA
Insertions
	Type of insertions Name Expression data insertion of mobile activating element P{EP}msl-3EP3144 NA P{EP}msl-3G3761 NA miscellaneous insertions P{SUPor-P}msl-3KG00939 NA insertion of enhancer trap binary system Mi{ET1}msl-3MB11711 No
Gene Ontology: Function, Process & Cellular Component ( 9 unique terms )
Terms Based on Experimental Evidence ( 4 terms )
Molecular Function
CV term Evidence References
chromatin binding inferred from direct assay (Gorman et al., 1995) methylated histone residue binding inferred from direct assay (Moore et al., 2010)
Biological Process
CV term Evidence References
dosage compensation inferred from mutant phenotype (Gorman et al., 1995)
Cellular Component
CV term Evidence References
X chromosome inferred from direct assay (Kotlikova et al., 2006)
Terms Based on Predictions or Assertions ( 8 terms )
Molecular Function
CV term Evidence References
chromatin binding non-traceable author statement (Swiss-Prot Project Members, 1996.10.1) mRNA binding traceable author statement (Amrein, 2000, Wutz, 2003)
Biological Process
CV term Evidence References
dosage compensation traceable author statement (Charlat et al., 2003) dosage compensation, by hyperactivation of X chromosome non-traceable author statement (Amrein, 2000, FlyBase, 1992-, Schutt and Nothiger, 2000, Swiss-Prot Project Members, 1996.10.1) traceable author statement (Carrozza et al., 2003)
Cellular Component
CV term Evidence References
chromosome non-traceable author statement (Swiss-Prot Project Members, 1996.10.1) nucleus inferred from electronic annotation with InterPro:IPR000953, InterPro:IPR008676 (FlyBase Curators et al., 2004-) non-traceable author statement (Swiss-Prot Project Members, 1996.10.1) X chromosome non-traceable author statement (Amrein, 2000) X chromosome located dosage compensation complex, transcription activating non-traceable author statement (FlyBase, 1992-, Schutt and Nothiger, 2000, Wutz, 2003) traceable author statement (Amrein, 2000)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions msl-3 allele Gene References msl-31 Sxl (Uenoyama et al., 1982)
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 64224 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0002775 DroID - A comprehensive database of gene and protein interactions. • FBgn0002775 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 38779
Orthologs
Genome-wide drosophilid orthologs	Dana\GF24792 Dere\GG14998 Dgri\GH17043 Dmoj\GI12047 Dper\GL25144 Dpse\GA21222 Dsec\GM13789 Dsim\GD13090 Dvir\msl-3 Dwil\GK17539 Dyak\GE20444
Curated drosophilid orthologs	Dame\msl-3 (Maside et al., 2004) Damx\msl-3 (Maside and Charlesworth, 2007) Dana\msl-3   Dezo\msl-3 (Maside and Charlesworth, 2007) Dfun\msl-3   Dlit\msl-3 (Maside and Charlesworth, 2007) Dmon\msl-3 (Maside and Charlesworth, 2007) Dpse\GA21222   Drob\msl-3   Dsim\msl-3   Dvir\msl-3
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL010054-PA Aedes aegypti (mosquito) AGAP001917-PA Anopheles gambiae (mosquito) XP_001121900.1 Apis mellifera (honey bee) XP_001944082.1 Acyrthosiphon pisum (pea aphid) 12855 Batrachochytrium dendrobatidis (chytrid fungus) 129977 Branchiostoma floridae (lancelet) BGIBMGA010146-PA Bombyx mori (silk worm) ENSBTAP00000030520 Bos taurus (bovine) ENSCAFP00000017070 Canis familiaris (dog) ENSCINP00000021859 Ciona intestinalis (sea squirt) ENSCINP00000029140 Ciona intestinalis (sea squirt) CPIJ007324 Culex pipens (mosquito) ENSCPOP00000004224 Cavia porcellus (guinea pig) ENSCSAVP00000015365 Ciona savignyi (sedentary tunicate) 223835 Capitella spl (polychaete worm) 222047 Daphnia pulex (daphnia) ENSECAP00000014407 Equus caballus (horse) ENSGACP00000019849 Gymnopilus aculeatus (mushroom) ENSGALP00000026739 Gallus gallus (chicken) ENSP00000312244 Homo sapiens (human) ISCW005187-PA Ixodes scapularis (deer tick) ENSMODP00000021652 Monodelphis domestica (gray opossum) ENSMMUP00000003621 Macaca mulatta (rhesus monkey) ENSMUSP00000033725 Mus musculus (house mouse) XP_001601672.1 Nasonia vitripennis (wasp) ENSOANP00000004172 Ornithorynchus anatinus (platypus) ENSORLP00000005915 Oryzias latipes (japanese killifish) PHUM004561-PA Pediculus humanus (human body louse) 122205 Physcomitrella patens (moss) 153977 Physcomitrella patens (moss) ENSPPYP00000022509 Pongo pygmaeus (orangutan) ENSPTRP00000045283 Pan troglodytes (chimpanzee) ENSRNOP00000005457 Rattus norvegicus (norway rat) 4815620 Sorghum bicolor (sorghum) XP_001196547.1 Strongylocentrotus purpuratus (purple sea urchin) 56822 Trichoplax adhaerens (metazoa) XP_970296.1 Tribolium castaneum (red flour beetle) XP_970319.1 Tribolium castaneum (red flour beetle) ENSTNIP00000017573 Tetraodon nigroviridis (green spotted pufferfish) ENSTRUP00000031948 Takifugu rubripes (pufferfish Takifugu) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB12477 NV14533 LH11938 ISCW005187 FBgn0237759 FBgn0219538 FBgn0015213 FBgn0184812 FBgn0168720 JGI_V11_222047 FBgn0081210 FBgn0162731 FBgn0134804 FBgn0124514 FBgn0107252 FBgn0101785 CPIJ007324 BGIBMGA010146 ACYPI43453 ACYPI21463 ACYPI000966 GB19559 AGAP001917 AAEL010054 PHUM492390 GLEAN_11005 GLEAN_15252
Stocks & Reagents
Stocks Listed in FlyBase ( 7 )
Bloomington	17095 w1118; P{EP}msl-3EP3144 29244 w1118; Mi{ET1}msl-3MB11711 27133 y1 w*; P{EP}msl-3G3761 35272 y1 sc* v1; P{TRiP.GL00170}attP2 5872 msl-31 red1/TM3, Sb1 Ser1 13165 y1 w67c23; P{SUPor-P}msl-3KG00939 ry506
VDRC	v2998 w1118; P{GD1492}v2998
Genomic Clones ( 1 )
	BACR21K18 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 58 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	RE14560
Other clones	DPiM_RE14560
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	LD18558 LD28873 LD30726 LD34661 LD45902 LD46009 LD47402 RE06094 RE16042 RE32284 RE52354 RE67082 RE70109
Other clones	82092 174462 EK217321 EK279338 RP003002968 RP003009545 RP003029644 RP003055032 RP003061002 RP003073025 RP003081535 RP003098772 RP003117299 RP003134845 RP003211776 RP003224061 RP003225268 RP003261879 RP003294031 RP003303707 RP003320923 RP003334614 RP003335003 RP003336324 RP003341299 RP003344760 RP003353748 RP003354755 RP003359082 RP003373482 RP003415918 RP003419127 RP003422766 RP003422962 RP003451136 RP003457576 RP003471971 RP003488955 RP003489688 RP003565683 RP003579298 RP003598139 RP003679946
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0002775 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 38779
Antibody Information
	polyclonal (Gorman et al., 1995)
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of
Additional comments
Other Comments
	Gene products of the male specific lethal (msl) group of genes preferentially associate with the male X chromosome and may have a role in dosage compensation. This may be achieved by regulating an inverse dosage effect, which would be maintained on the male X and nullified on the autosomes. (Bhadra et al., 1999) Gene products of the male specific lethal (msl) group of genes including msl-1, msl-2, msl-3, mle, and mof are associated with all female chromosomes at a low level but are sequestered to the X chromosome in males. There is evidence for the presence of nucleation sites for association of msl proteins with the X chromosome rather than individual gene binding sites. (Bhadra et al., 1999) mof colocalises with the MSL complex on the X chromosome: a sequence of binding events results in the formation of the MSL complex on the X chromosome in males and in the targeting of mof to its presumed site of action. (Gu et al., 1998) msl-2 and msl-1 colocalise to a reproducible subset of their wild-type X chromosome sites in the absence of either mle or msl-3. (Lyman et al., 1997) Male-specific lethal (MSL) proteins accumulate in a subregion of male nuclei (the X chromosome) beginning at late blastoderm stage. X chromosomal binding of the MSLs is observed throughout embryonic and larval development in both diploid and polytene tissues. His4 colocalises with the MSLs in embryos. Binding of the MSLs is interdependent in diploid cells and is prevented in female embryonic cells by Sxl. (Franke et al., 1996) Sex- and chromosome-specific binding of the male-specific lethal (msl) proteins occurs in Drosophilid species spanning 4 genera. msl binding correlates with the evolution of the sex chromosomes. (Marin et al., 1996) The products of msl-1, msl-2, mle and msl-3 loci specifically associate with hundreds of sites along the X chromosome in males, but not in females. The binding of each of the four proteins requires the functional products from the other three. 2X3A individuals are mosaic for both Sxl expression and msl-1, msl-2, mle and msl-3 binding to the X chromosome, with a perfect inverse correlation at the cellular level between Sxl expression and msl-1, msl-2, mle and msl-3 X chromosome binding. (Baker, 1995) Immunostaining of embryonic and larval stages demonstrates that His4, msl-1 and msl-3 are associated with the male X chromosome as early as gastrulation, while mle binding is not detected until the late embryonic/late larval stages. (Franke and Baker, 1995) The msl-3, mle and msl-1 gene products may associate with one another in a male-specific heteromeric complex on the X chromosome to achieve its hyperactivation. (Gorman et al., 1995) Elements needed for dosage compensation are localised to the X chromosome only after blastoderm and msl-dependent dosage compensation is not necessary during the first part of embryogenesis. This suggest the existance of an additional msl-independent dosage compensation mechanism; dosage compensation of run expression at blastoderm is not dependent on male specific lethal genes. (Rastelli and Kuroda, 1995) The msl-2 primary transcript may play a role in male-specific binding of mle, msl-3 and msl-1 to the X chromosome. (Zhou et al., 1995) Association of H4Ac16 protein with the male X chromosome requires wild type function of msl-1, msl-2, mle and msl-3. (Bone et al., 1994) The four msl gene products interact to form a multiprotein complex. (Hilfiker et al., 1994) The X chromosome binding of mle requires wild type msl-1, msl-2 and msl-3 functions. (Gorman et al., 1993) Mutants are defective for dosage compensation in males. Homozygous males exhibit delayed development; survive as larvae for ten days. Ten-day-old male larvae have small undeveloped imaginal discs, which, however, when transplanted into wild type larvae are capable of undergoing nearly complete (wing, leg) or partial (eye-antenna) differentiation. Mutants show no interaction with mle1. Females transformed into phenotypic males (tra1, tra21) or intersexes (dsx1) are unaffected by msl-31, i.e. msl-31 acts only upon single-X-bearing flies. (Lindsley and Zimm, 1992) Staining of polytene X chromosome of msl-3 males similar to that of mle males. (Lucchesi et al., 1982, Okuno et al., 1984) Few homozygous msl-32 gynandromorphs survive; X0 patches small, with small bristles and mostly confined to abdomen. (Uenoyama et al., 1982)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_079227 NM_168191 RefSeq (Proteins) • NP_523951 NP_729213 DDBJ / EMBL / GenBank • AAF50612 AAL48696 AAN12073 AQ073780 AY071074 BH614844 BI172248 CAA57101 X81321 Entrez Gene - A searchable database of RefSeq genes. • 38779 UniProtKB/Swiss-Prot • P50536
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Chromo domain/shadow (IPR000953) MRG (IPR008676) Chromo domain-like (IPR016197)
Linkouts
	BioGRID - A database of protein and genetic interactions • 64224 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0002775 DroID - A comprehensive database of gene and protein interactions. • FBgn0002775 DRSC - Results from RNAi screens. • FBgn0002775 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0002775 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG8631-RB;CG8631-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0002775 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 38779 InParanoid A subset of ortholog calls from InParanoid. • AAEL010054-PA Aedes aegypti (mosquito) AGAP001917-PA Anopheles gambiae (mosquito) XP_001121900.1 Apis mellifera (honey bee) XP_001944082.1 Acyrthosiphon pisum (pea aphid) 12855 Batrachochytrium dendrobatidis (chytrid fungus) 129977 Branchiostoma floridae (lancelet) BGIBMGA010146-PA Bombyx mori (silk worm) ENSBTAP00000030520 Bos taurus (bovine) ENSCAFP00000017070 Canis familiaris (dog) ENSCINP00000021859 Ciona intestinalis (sea squirt) ENSCINP00000029140 Ciona intestinalis (sea squirt) CPIJ007324 Culex pipens (mosquito) ENSCPOP00000004224 Cavia porcellus (guinea pig) ENSCSAVP00000015365 Ciona savignyi (sedentary tunicate) 223835 Capitella spl (polychaete worm) 222047 Daphnia pulex (daphnia) ENSECAP00000014407 Equus caballus (horse) ENSGACP00000019849 Gymnopilus aculeatus (mushroom) ENSGALP00000026739 Gallus gallus (chicken) ENSP00000312244 Homo sapiens (human) ISCW005187-PA Ixodes scapularis (deer tick) ENSMODP00000021652 Monodelphis domestica (gray opossum) ENSMMUP00000003621 Macaca mulatta (rhesus monkey) ENSMUSP00000033725 Mus musculus (house mouse) XP_001601672.1 Nasonia vitripennis (wasp) ENSOANP00000004172 Ornithorynchus anatinus (platypus) ENSORLP00000005915 Oryzias latipes (japanese killifish) PHUM004561-PA Pediculus humanus (human body louse) 122205 Physcomitrella patens (moss) 153977 Physcomitrella patens (moss) ENSPPYP00000022509 Pongo pygmaeus (orangutan) ENSPTRP00000045283 Pan troglodytes (chimpanzee) ENSRNOP00000005457 Rattus norvegicus (norway rat) 4815620 Sorghum bicolor (sorghum) XP_001196547.1 Strongylocentrotus purpuratus (purple sea urchin) 56822 Trichoplax adhaerens (metazoa) XP_970296.1 Tribolium castaneum (red flour beetle) XP_970319.1 Tribolium castaneum (red flour beetle) ENSTNIP00000017573 Tetraodon nigroviridis (green spotted pufferfish) ENSTRUP00000031948 Takifugu rubripes (pufferfish Takifugu) Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution • /polycomb/msl3-1.htm InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 38779 modMine - Data generated by the modENCODE project. • FBgn0002775 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB12477 NV14533 LH11938 ISCW005187 FBgn0237759 FBgn0219538 FBgn0015213 FBgn0184812 FBgn0168720 JGI_V11_222047 FBgn0081210 FBgn0162731 FBgn0134804 FBgn0124514 FBgn0107252 FBgn0101785 CPIJ007324 BGIBMGA010146 ACYPI43453 ACYPI21463 ACYPI000966 GB19559 AGAP001917 AAEL010054 PHUM492390 GLEAN_11005 GLEAN_15252
Synonyms & Secondary IDs ( 18 )
Reported As
Symbol Synonym	CG8631 (Ni et al., 2011.7.19) DmMsl-3 (Bertram and Pereira-Smith, 2001) mle3 (Banfi et al., 1996, Williams, 1995, Lindsley and Zimm, 1992) mle(3)132 (Uenoyama, 1984) mls3 (Birchler et al., 1998) msl (Cline, 2005, Johansen et al., 1999, Pal-Bhadra et al., 2000, Amrein, 1999, Bhadra et al., 1999, Baker, 1998, Hodgkin, 1990) MSL (Pannuti et al., 2005, Minear et al., 2005, Larsson et al., 2003, Morey and Avner, 2004, Park et al., 2004, Rogers et al., 2003, Kelley and Kuroda, 2003, Park and Kuroda, 2001, Kelley and Kuroda, 2001, Kelley and Kuroda, 2000, Amrein and Dunipace, 2000, Meller and Paskus Warden, 2000, Meller and Paskus Warden, 1999, Kuroda, 1998, Hennig, 1999, Kong and Meller, 2008) Msl 1-3 (Schubeler, 2006) msl3 (Kotlikova et al., 2006, Straub et al., 2005, Meller, 2000, Bai et al., 2004, Oh et al., 2004, Dahlsveen et al., 2003, Rattner and Meller, 2004, Deng and Meller, 2004, Meller, 2003, Park et al., 2003, Amrein, 2000, Deng and Meller, 2003, Jin et al., 2000, Mahesh and Ranganath, 2000, Kelley et al., 2000, Meller et al., 2000, Kelley et al., 1999, Cline and Meyer, 1996, Gorman et al., 1993, Sural and Kuroda, 2006, Alekseyenko et al., 2006, Rodriguez et al., 2007, Worringer and Panning, 2007, Li et al., 2008, Levine et al., 2007, Alekseyenko et al., 2008, Larschan et al., 2007, Larschan et al., 2007, Gorchakov et al., 2009, Spierer et al., 2008, Prabhakaran and Kelley, 2010, Sural et al., 2008, Moore et al., 2010) MSL3 (Nusinow, 2005, Hamada et al., 2005, Larsson et al., 2004, Morales et al., 2004, Gilfillan et al., 2004, Kelley, 2004, Sural and Kuroda, 2004, Andersen and Panning, 2003, Carrozza et al., 2003, Deng and Meller, 2002, Wang et al., 2001, Rattner and Meller, 2001, Pannuti and Lucchesi, 2000, Kelley and Kuroda, 2000, Gu et al., 2000, Scott et al., 2000, Stuckenholz et al., 1999, Copps et al., 1998, Koonin et al., 1995, Straub and Becker, 2007, Dahlsveen et al., 2006, Deng and Meller, 2006, Alekseyenko et al., 2006, Gilfillan et al., 2006, Prasanth and Spector, 2007, Furuhashi et al., 2006, Deng and Meller, 2006, Mendjan and Akhtar, 2007, Morales et al., 2005, Li et al., 2005, Park et al., 2007, Kind et al., 2008, Straub et al., 2008, Grimaud and Becker, 2009, Gelbart et al., 2009, Weake and Scott, 2007, Raja et al., 2010, Sural et al., 2008, Kim et al., 2010, Moore et al., 2010, Gorchakov et al., 2010, Schiemann et al., 2010, Gorchakov et al., 2010) Msl3 (Yang, 2004, Carré et al., 2008) MSL-3 (de la Cruz et al., 2005, Franke and Baker, 1999, Panning and Jaenisch, 1998, Franke and Baker, 1995, Legube et al., 2006, Mendjan and Akhtar, 2007, Patalano et al., 2009) msl-3 (Mendjan et al., 2006, Kind and Akhtar, 2007, Doheny et al., 2008, Gilfillan et al., 2007, Pierre et al., 2008, Zhimulev et al., 2003, Buscaino et al., 2006, Barbash, 2010, Gladstein et al., 2010)
Name Synonym	gene 2 (Gorman et al., 1995) male sex lethal 3 (Doheny et al., 2008) male specifc lethal (Rogers et al., 2003) male-specific lethal 3 (Prasanth and Spector, 2007, Prabhakaran and Kelley, 2010) male specific lethal 3 (Raja et al., 2010)
Secondary FlyBase IDs
References ( 221 )
Generate a list of	All references relating to this gene ( 221 )
List References by type	Research paper  ( 101 ) Supplementary material  ( 4 ) Review  ( 56 ) Personal communication to FlyBase  ( 8 ) Abstract  ( 41 ) FlyBase analysis  ( 1 ) Book  ( 1 ) DNA/RNA sequence record  ( 1 ) Protein sequence record  ( 1 ) Computer file  ( 2 ) Letter  ( 2 ) Automatic genome annotation  ( 1 ) Curated genome annotation  ( 1 )
Recent research papers ( 9 )
	Barbash, 2010, Genetics 184(1): 313--316 Genetic testing of the hypothesis that hybrid male lethality results from a failure in dosage compensation. [FBrf0209660] Gladstein et al., 2010, PLoS Genet. 6(7): e1001041 Requirement of male-specific dosage compensation in Drosophila females-implications of early X chromosome gene expression. [FBrf0211448] Gorchakov et al., 2010, Russ. J. Genet. 46(10): 1263--1266 Dosage compensation in drosophila: Sequence-specific initiation and sequence-independent spreading of MSL complex to the active genes on the male X chromosome. [FBrf0215196] Gorchakov et al., 2010, Genetika, Moscow 46(10): 1430--1434 [Dosage compensation in drosophila: sequence-specific initiation and sequence-independent spreading of MSL complex to the active genes on the male X chromosome]. [FBrf0212823] Kim et al., 2010, Nat. Struct. Mol. Biol. 17(8): 1027--1029 Corecognition of DNA and a methylated histone tail by the MSL3 chromodomain. [FBrf0214093] Moore et al., 2010, J. Biol. Chem. 285(52): 40879--40890 Structural and biochemical studies on the chromo-barrel domain of male specific lethal 3 (MSL3) reveal a binding preference for mono- or dimethyllysine 20 on histone H4. [FBrf0212637] Prabhakaran and Kelley, 2010, BMC Biol. 8: 80 A new strategy for isolating genes controlling dosage compensation in Drosophila using a simple epigenetic mosaic eye phenotype. [FBrf0211122] Raja et al., 2010, Mol. Cell 38(6): 827--841 The Nonspecific Lethal Complex Is a Transcriptional Regulator in Drosophila. [FBrf0211222] Schiemann et al., 2010, Biochem. Biophys. Res. Commun. 402(4): 699--704 The importance of location and orientation of male specific lethal complex binding sites of differing affinities on reporter gene dosage compensation in Drosophila. [FBrf0212385] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2010 Show reviews ...