FlyBase Gene Report: Dmel\mnd

General Information

Symbol

Dmel\mnd

Species

D. melanogaster

Name

minidiscs

Annotation Symbol

CG3297

Feature Type

protein_coding_gene

FlyBase ID

FBgn0002778

Gene Model Status

Current

Stock Availability

9 publicly available

Gene Snapshot

minidiscs (mnd) encodes the putative amino acid/polyamine transporter involved in leucine import. It is expressed in the larval fat body and is required for the differentiation of the wing imaginal disc cells. [Date last reviewed: 2019-03-14]

Other Summaries

Alliance
Auto summary
Gene Group
Red Book
Interactive Fly

Key Links

Genomic Location

Cytogenetic map

71A4-71B1

Sequence location

3L:14,985,100..14,991,667 [+]

Recombination map

3-42

RefSeq locus

NT_037436 REGION:14985100..14991667

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse GBrowse

Help me choose

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

GO Summary Ribbons

Gene Ontology (GO) Annotations (5 terms)

Molecular Function (2 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

enables amino acid transmembrane transporter activity

traceable author statement

(Bradley and Leevers, 2003)

enables L-amino acid transmembrane transporter activity

inferred from biological aspect of ancestor with PANTHER:PTN000208507

(assigned by GO_Central )

(Gaudet et al., 2011)

Biological Process (2 terms)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

involved_in L-leucine import across plasma membrane

inferred from mutant phenotype

(Reynolds et al., 2009)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

involved_in amino acid transport

traceable author statement

(Bradley and Leevers, 2003)

Cellular Component (1 term)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

located_in membrane

inferred from electronic annotation with InterPro:IPR002293

(assigned by InterPro )

(FlyBase Curators et al., 2004-)

Gene Group (FlyBase)

L-TYPE AMINO ACID TRANSPORTERS

Protein Family (UniProt)

Protein Signatures (InterPro)

Amino acid/polyamine transporter I

Summaries

Gene Group (FlyBase)

L-TYPE AMINO ACID TRANSPORTERS -: L-type amino acid transporters (LATs) are system L, Na[+]-independent transporters responsible for transport of bulky neutral amino acids. LATs form the light chains or catalytic chains of the heterodimeric amino acid transporters (HATs). (Adapted from FBrf0207965 and PMID:14770310).

Phenotypic Description (Red Book; Lindsley and Zimm 1992)

l(3)SG29

Homozygous larvae do not form puparia; imaginal discs never attain size of those in young third-instar larvae. Mutant discs transplanted into wild-type female abdomens decrease in size and disappear during the first three days; however, in transplanted mixtures of wild-type and mutant embryonic cells allowed to pass through metamorphosis, mutant cells appear in cuticular derivatives from all discs. Wildtype discs transplanted into mutant larvae are capable of reduced growth and of differentiation upon retransplantation into wild-type larvae. Alleles with more extreme effects (i.e., larval death in early second instar) and less severe effects (pharate adults that do not eclose) noted (Shearn, Hersperger, Hersperger, Pentz, and Denker, 1978, Genetics 89: 355-70).

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\mnd for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Comments on Gene Model

Low-frequency RNA-Seq exon junction(s) not annotated.

Annotated transcripts do not represent all supported alternative splices within 5' UTR.

Annotated transcripts do not represent all possible combinations of alternative exons and/or alternative promoters.

Gene model reviewed during 5.46

Gene model reviewed during 5.55

Sequence Ontology: Class of Gene

nuclear_gene

protein_coding_gene

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

mnd-RA

FBtr0075627

NM_079350

2491

499

mnd-RC

FBtr0075626

NM_168601

2376

499

mnd-RD

FBtr0114529

NM_168600

2046

499

Additional Transcript Data and Comments

Reported size (kB)

2.3 (northern blot, compiled cDNA)

(Martin et al., 2000)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

RefSeq ID

GenBank

mnd-PA

FBpp0075380

54.3

499

6.71

NP_524074

AAF49688

mnd-PC

FBpp0075379

54.3

499

6.71

NP_730006

AAN11782

mnd-PD

FBpp0113021

54.3

499

6.71

NP_730005

AAN11781

Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

499 aa isoforms: mnd-PA, mnd-PC, mnd-PD

Additional Polypeptide Data and Comments

Reported size (kDa)

499 (aa); 54.3 (kD predicted)

(Martin et al., 2000)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Amino acid/polyamine transporter I

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Q9Y1A7

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\mnd using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

mnd_1
mnd_2

Linkouts

Expression Data

Expression Summary Ribbons

Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.

For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 1 -- 3

organism

Comment: maternally deposited

(Fisher et al., 2012)

embryonic stage 4 -- 6

posterior ectoderm anlage

Comment: anlage in statu nascendi

(Fisher et al., 2012)

yolk nucleus

(Fisher et al., 2012)

embryonic stage 7 -- 8

yolk nucleus

(Fisher et al., 2012)

embryonic stage 9 -- 10

yolk nucleus

(Fisher et al., 2012)

embryonic stage 11 -- 12

anterior midgut primordium

(Fisher et al., 2012)

hindgut proper primordium

(Fisher et al., 2012)

posterior midgut primordium

(Fisher et al., 2012)

salivary gland body primordium

(Fisher et al., 2012)

embryonic stage 13 -- 16

embryonic brain

(Fisher et al., 2012)

embryonic Malpighian tubule

(Fisher et al., 2012)

embryonic/larval fat body

(Fisher et al., 2012)

embryonic/larval midgut

(Fisher et al., 2012)

embryonic/larval salivary gland body

(Fisher et al., 2012)

ventral nerve cord

(Fisher et al., 2012)

northern blot

Stage

Tissue/Position (including subcellular localization)

Reference

first instar larval stage -- second instar larval stage

organism

(Martin et al., 2000)

embryonic stage

(Martin et al., 2000)

third instar larval stage

embryonic/larval fat body

(Martin et al., 2000)

adult stage

(Martin et al., 2000)

Additional Descriptive Data

mnd transcript levels are high during embryonic and early larval stages, but drop to very low levels during larval and pupal development. Transcripts are detected in the adult, and specifically by in situ in the larval fat body.

(Martin et al., 2000)

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

mass spectroscopy

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

adult head

• membrane

(Aradska et al., 2015)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\mnd in GBrowse 2

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\mnd

View exonic expression by tissue for Dmel\mnd

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0002778

FLIGHT - Cell culture data for RNAi and other high-throughput technologies

FBgn0002778

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

CG3297-RB

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG3297

Flygut - An atlas of the Drosophila adult midgut

FBgn0002778

Images

FlyExpress - Embryonic expression images (BDGP data)

Show all FlyExpress processed images for Dmel\mnd

Stages(s) 4-6
Stages(s) 7-8
Stages(s) 11-12
Stages(s) 13-16

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 49 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 4 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of mnd

Transgenic constructs containing regulatory region of mnd

Aberrations (Deficiencies and Duplications) ( 4 )

Inferred from experimentation

Gene disrupted in

Df(3L)BSC441

(Christensen et al., 2008.4.15)

Df(3L)BSC837

(Christensen et al., 2009.7.22)

Df(3L)Exel6125

(Ryder, 2004.4.26)

Df(3L)Exel6126

(Ryder, 2004.4.26)

Inferred from location

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

lethal

lethal | cold sensitive

mnd²²

lethal | heat sensitive

mnd²¹

lethal - all die before end of larval stage | recessive

viable

mnd^EY00526

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

mnd^GD453

viable, with Scer\GAL4^Mef2.PR

mnd^GD453

viable, with Scer\GAL4^pnr-MD237

mnd^GD453

viable, with Scer\GAL4^tin.CΔ4

mnd^GD453

Sterility

Allele

fertile

mnd^EY00526

Other Phenotypes

Allele

some die during larval stage | recessive

wild-type

mnd^hs.Tag:FLAG

Phenotype manifest in

Allele

adult

adult | adult stage A1

mnd⁶

embryo

mnd³⁵

embryonic/larval brain

embryonic/larval fat body | wandering third instar larval stage

mnd⁴

eye-antennal disc

mnd¹

genital disc

mnd¹

haltere disc

mnd¹

imaginal disc

larva

mnd¹

larva | second instar larval stage

mnd³¹

larva | third instar larval stage

pupa

ventral thoracic disc

mnd¹

Orthologs

Downloads

Download All DIOPT Orthologs

Download All OrthoDB Orthologs

Human Orthologs (via DIOPT v8.0)

Homo sapiens (Human) (24)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Hsap\SLC7A7

9 of 15

Yes

Hsap\SLC7A5

8 of 15

Hsap\SLC7A6

8 of 15

Hsap\SLC7A8

8 of 15

Yes

Hsap\SLC7A9

6 of 15

Hsap\SLC7A10

6 of 15

Hsap\SLC7A11

6 of 15

Yes

4 of 15

2 of 15

2 of 15

2 of 15

2 of 15

2 of 15

1 of 15

Yes

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

Model Organism Orthologs (via DIOPT v8.0)

Mus musculus (laboratory mouse) (25)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Mmus\Slc7a7

8 of 15

Yes

Mmus\Slc7a8

8 of 15

Yes

7 of 15

7 of 15

6 of 15

6 of 15

Yes

Mmus\Slc7a11

5 of 15

Yes

4 of 15

4 of 15

4 of 15

2 of 15

2 of 15

2 of 15

2 of 15

2 of 15

2 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

Rattus norvegicus (Norway rat) (26)

Rnor\Slc7a5

7 of 13

Yes

Rnor\Slc7a7

7 of 13

Yes

Rnor\Slc7a8

7 of 13

Yes

Rnor\Slc7a6

6 of 13

Rnor\Slc7a11

6 of 13

Yes

5 of 13

5 of 13

4 of 13

4 of 13

4 of 13

4 of 13

4 of 13

2 of 13

Yes

Rnor\LOC100911244

2 of 13

Yes

2 of 13

2 of 13

2 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Xenopus tropicalis (Western clawed frog) (23)

Xtro\slc7a6

7 of 12

Yes

Xtro\slc7a7

7 of 12

Yes

Xtro\LOC100492274

6 of 12

Yes

6 of 12

5 of 12

4 of 12

4 of 12

4 of 12

4 of 12

3 of 12

2 of 12

Yes

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Danio rerio (Zebrafish) (35)

Drer\slc7a8a

9 of 15

Yes

Drer\slc7a7

8 of 15

Yes

Drer\slc7a8b

8 of 15

Yes

Drer\slc7a5

7 of 15

Drer\slc7a6

7 of 15

Drer\si:ch73-352p4.8

6 of 15

Yes

Drer\slc7a10a

6 of 15

Yes

Drer\slc7a10b

6 of 15

Yes

Drer\slc7a11

6 of 15

Yes

Drer\si:dkeyp-120h9.1

5 of 15

Drer\slc7a9

5 of 15

Drer\zmp:0000001267

4 of 15

Drer\LOC100150834

2 of 15

Yes

2 of 15

2 of 15

2 of 15

2 of 15

2 of 15

Drer\si:cabz01090193.1

1 of 15

Drer\si:ch211-59d13.2

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

Caenorhabditis elegans (Nematode, roundworm) (20)

Cele\aat-2

13 of 15

Yes

Cele\aat-1

5 of 15

Cele\aat-4

5 of 15

Yes

Cele\aat-3

4 of 15

Cele\aat-5

4 of 15

Cele\aat-6

4 of 15

Yes

Cele\aat-7

4 of 15

Yes

Cele\aat-8

4 of 15

Yes

Cele\aat-9

4 of 15

Yes

2 of 15

2 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

Arabidopsis thaliana (thale-cress) (5)

Atha\PUT1

1 of 9

Yes

Atha\PUT2

1 of 9

Yes

Atha\PUT4

1 of 9

Yes

Atha\PUT5

1 of 9

Yes

Atha\RMV1

1 of 9

Yes

Saccharomyces cerevisiae (Brewer's yeast) (25)

Scer\MUP1

9 of 15

Yes

Scer\MUP3

9 of 15

Yes

3 of 15

3 of 15

3 of 15

2 of 15

2 of 15

2 of 15

2 of 15

2 of 15

2 of 15

1 of 15

1 of 15

1 of 15

Yes

1 of 15

1 of 15

1 of 15

1 of 15

Yes

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

Yes

Scer\UGA4

1 of 15

Scer\VHC1

1 of 15

Schizosaccharomyces pombe (Fission yeast) (13)

Spom\per1

2 of 12

Yes

Spom\SPAC1039.01

2 of 12

Yes

Spom\SPCC584.13

2 of 12

Yes

Spom\SPCPB1C11.02

2 of 12

Yes

Spom\isp5

1 of 12

Spom\meu22

1 of 12

Spom\SPAC11D3.08c

1 of 12

Yes

Spom\SPAPB24D3.02c

1 of 12

Spom\SPBC15C4.04c

1 of 12

Yes

Spom\SPCC74.04

1 of 12

Yes

Spom\SPCC794.03

1 of 12

Yes

Spom\SPCC965.11c

1 of 12

Spom\thi9

1 of 12

Ortholog(s) in Drosophila Species (via OrthoDB v9.1) ( EOG091907GO )

Organism

Common Name

Gene

AAA Syntenic Ortholog

Multiple Dmel Genes in this Orthologous Group

Drosophila suzukii

Spotted wing Drosophila

Drosophila simulans

Drosophila sechellia

Drosophila erecta

Drosophila yakuba

Drosophila ananassae

Drosophila pseudoobscura pseudoobscura

Dpse\GA23621

Drosophila persimilis

Dper\GL24697

Drosophila willistoni

Dwil\GK10548

Drosophila virilis

Dvir\GJ11604

Drosophila mojavensis

Dmoj\GI11350

Drosophila grimshawi

Dgri\GH16664

Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG0915056B )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Musca domestica

House fly

Mdoa\17017724

Glossina morsitans

Tsetse fly

Gmor\GMOY010388

Lucilia cuprina

Australian sheep blowfly

Lcup\FF38_04644

Mayetiola destructor

Hessian fly

Mdes\Mdes004286

Aedes aegypti

Yellow fever mosquito

Aaeg\AAEL014161

Anopheles darlingi

American malaria mosquito

Adar\ADAC007272

Anopheles gambiae

Malaria mosquito

Agam\AGAP011386

Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W0690 )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Bombyx mori

Silkmoth

Bmor\BGIBMGA010801

Bombyx mori

Silkmoth

Bmor\BGIBMGA003856

Bombyx mori

Silkmoth

Bmor\BGIBMGA003178

Danaus plexippus

Monarch butterfly

Dple\DPOGS211114-PA

Danaus plexippus

Monarch butterfly

Dple\DPOGS211190-PA

Danaus plexippus

Monarch butterfly

Dple\DPOGS206269-PA

Danaus plexippus

Monarch butterfly

Dple\DPOGS203336-PA

Heliconius melpomene

Postman butterfly

Hmel\HMEL012433

Heliconius melpomene

Postman butterfly

Hmel\HMEL017938

Heliconius melpomene

Postman butterfly

Hmel\HMEL012437

Heliconius melpomene

Postman butterfly

Hmel\HMEL016902

Apis florea

Little honeybee

Aflo\4829745732

Apis florea

Little honeybee

Aflo\3771754628

Apis florea

Little honeybee

Aflo\4476379268

Apis mellifera

Western honey bee

Amel\GB49475

Apis mellifera

Western honey bee

Amel\GB45365

Bombus impatiens

Common eastern bumble bee

Bimp\BIMP18217

Bombus impatiens

Common eastern bumble bee

Bimp\BIMP13199

Bombus impatiens

Common eastern bumble bee

Bimp\BIMP24573

Bombus terrestris

Buff-tailed bumblebee

Bter\15212035

Bombus terrestris

Buff-tailed bumblebee

Bter\15206521

Bombus terrestris

Buff-tailed bumblebee

Bter\15210734

Linepithema humile

Argentine ant

Lhum\LH20584

Linepithema humile

Argentine ant

Lhum\LH13987

Linepithema humile

Argentine ant

Lhum\LH18192

Megachile rotundata

Alfalfa leafcutting bee

Mrot\MROTU:000bdf

Megachile rotundata

Alfalfa leafcutting bee

Mrot\MROTU:000a87

Megachile rotundata

Alfalfa leafcutting bee

Mrot\MROTU:001a93

Nasonia vitripennis

Parasitic wasp

Nvit\Nasvi2EG008076

Nasonia vitripennis

Parasitic wasp

Nvit\Nasvi2EG010326

Nasonia vitripennis

Parasitic wasp

Nvit\Nasvi2EG000364

Dendroctonus ponderosae

Mountain pine beetle

Dpod\YQE_06196

Dendroctonus ponderosae

Mountain pine beetle

Dpod\YQE_07231

Dendroctonus ponderosae

Mountain pine beetle

Dpod\YQE_10990

Dendroctonus ponderosae

Mountain pine beetle

Dpod\YQE_12948

Tribolium castaneum

Red flour beetle

Tcas\TC013142

Tribolium castaneum

Red flour beetle

Tcas\TC011826

Tribolium castaneum

Red flour beetle

Tcas\TC013186

Tribolium castaneum

Red flour beetle

Tcas\TC000687

Pediculus humanus

Human body louse

Phum\PHUM136660

Pediculus humanus

Human body louse

Phum\PHUM050830

Pediculus humanus

Human body louse

Phum\PHUM433680

Pediculus humanus

Human body louse

Phum\PHUM462600

Rhodnius prolixus

Kissing bug

Rpro\RPRC005487

Rhodnius prolixus

Kissing bug

Rpro\RPRC009572

Rhodnius prolixus

Kissing bug

Rpro\RPRC011462

Rhodnius prolixus

Kissing bug

Rpro\RPRC008013

Cimex lectularius

Bed bug

Clec\CLEC008942

Cimex lectularius

Bed bug

Clec\CLEC000591

Cimex lectularius

Bed bug

Clec\CLEC004068

Acyrthosiphon pisum

Pea aphid

Apim\ACYPI005720

Acyrthosiphon pisum

Pea aphid

Apim\ACYPI061470

Acyrthosiphon pisum

Pea aphid

Apim\ACYPI009467

Zootermopsis nevadensis

Nevada dampwood termite

Znev\Znev_13755

Zootermopsis nevadensis

Nevada dampwood termite

Znev\Znev_12896

Zootermopsis nevadensis

Nevada dampwood termite

Znev\Znev_01180

Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X064D )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Strigamia maritima

European centipede

Smar\SMAR000770

Strigamia maritima

European centipede

Smar\SMAR000861

Strigamia maritima

European centipede

Smar\SMAR007645

Strigamia maritima

European centipede

Smar\SMAR007109

Ixodes scapularis

Black-legged tick

Isca\ISCW007102

Ixodes scapularis

Black-legged tick

Isca\ISCW021910

Stegodyphus mimosarum

African social velvet spider

Smim\KFM72858.1

Stegodyphus mimosarum

African social velvet spider

Smim\KFM72437.1

Tetranychus urticae

Two-spotted spider mite

Turt\tetur04g06230

Tetranychus urticae

Two-spotted spider mite

Turt\tetur08g05730

Daphnia pulex

Water flea

Dpux\DAPPUDRAFT_308208

Daphnia pulex

Water flea

Dpux\DAPPUDRAFT_41191

Daphnia pulex

Water flea

Dpux\DAPPUDRAFT_309272

Daphnia pulex

Water flea

Dpux\DAPPUDRAFT_129136

Daphnia pulex

Water flea

Dpux\DAPPUDRAFT_324131

Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G07EM )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Slc7a8

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Slc7a11_6

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Slc7a9_1

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Slc7a11_2

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Slc7_2

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Slc7a11_11

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Slc7a9_4

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Lec7a6_9

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Slc7a6_3

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Slc7a9

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Slc7a11_9

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Slc7a6_8

Strongylocentrotus purpuratus

Purple sea urchin

Spur\SPU_027794gn

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Slc7a6_2

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Slc7a9_2

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Slc7a11_4

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Slc7a11

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Slc7a11_1

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Slc7a11_8

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Slc7a6_1

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Slc7a11_12

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Slc7a6

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Slc7a8_2

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Slc7a11_5

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-transaa

Ciona intestinalis

Vase tunicate

Cint\LOC100178457

Ciona intestinalis

Vase tunicate

Cint\LOC100187319

Ciona intestinalis

Vase tunicate

Cint\LOC100176621

Ciona intestinalis

Vase tunicate

Cint\LOC100176239

Ciona intestinalis

Vase tunicate

Cint\LOC100176605

Ciona intestinalis

Vase tunicate

Cint\LOC100179719

Ciona intestinalis

Vase tunicate

Cint\LOC100181560

Ciona intestinalis

Vase tunicate

Cint\LOC100176711

Ciona intestinalis

Vase tunicate

Cint\LOC100179666

Ciona intestinalis

Vase tunicate

Cint\LOC100177320

Ciona intestinalis

Vase tunicate

Cint\LOC100178717

Gallus gallus

Domestic chicken

Ggal\SLC7A7

Gallus gallus

Domestic chicken

Ggal\SLC7A5

Gallus gallus

Domestic chicken

Ggal\SLC7A10

Gallus gallus

Domestic chicken

Ggal\SLC7A6

Gallus gallus

Domestic chicken

Ggal\LOC421965

Gallus gallus

Domestic chicken

Ggal\SLC7A9

Gallus gallus

Domestic chicken

Ggal\LOC418109

Gallus gallus

Domestic chicken

Ggal\ENSGALG00000027863

Gallus gallus

Domestic chicken

Ggal\SLC7A11

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v8.0)

Drosophila melanogaster (Fruit fly) (15)

Gene Symbol

Score

Source

Alignment

8 of 10

sbm

8 of 10

JhI-21

7 of 10

6 of 10

3 of 10

2 of 10

2 of 10

2 of 10

2 of 10

1 of 10

1 of 10

kcc

1 of 10

Ncc69

1 of 10

NKCC

1 of 10

tadr

1 of 10

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Model Summary Ribbon

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 1 )

Human Ortholog

Disease

Evidence

References

SLC7A7; solute carrier family 7 member 7

model of lysinuric protein intolerance

IEA

(FlyBase, 2019-)

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

SLC7A7; solute carrier family 7 member 7

9 of 15

603593

LYSINURIC PROTEIN INTOLERANCE; LPI

lysinuric protein intolerance

SLC7A5; solute carrier family 7 member 5

8 of 15

600182

SLC7A6; solute carrier family 7 member 6

8 of 15

605641

SLC7A8; solute carrier family 7 member 8

8 of 15

604235

SLC7A9; solute carrier family 7 member 9

6 of 15

604144

CYSTINURIA

cystinuria

SLC7A10; solute carrier family 7 member 10

6 of 15

607959

SLC7A11; solute carrier family 7 member 11

6 of 15

607933

SLC7A13; solute carrier family 7 member 13

4 of 15

617256

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

esyN Network Diagram

Interactions Browser

View in Interactions Browser

Please see the Physical Interaction reports below for full details

RNA-RNA

Physical Interaction

Assay

References

mnd - mir-210

luminiscence technology, phenotype-based detection assay, quantitative reverse transcription pcr

(Cusumano et al., 2018)

Summary of Genetic Interactions

esyN Network Diagram

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

External Data

Linkouts

BioGRID - A database of protein and genetic interactions.

64949

DroID - A comprehensive database of gene and protein interactions.

FBgn0002778

InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.

39625

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

External Data

Linkouts

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

3-42

Cytogenetic map

71A4-71B1

Sequence location

3L:14,985,100..14,991,667 [+]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

71A4-71B1

Limits computationally determined from genome sequence between P{PZ}Mpcp⁰⁰⁵⁶⁴ and P{PZ}l(3)rO220^rO220

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

70F-71A

(Martin, 1999.3.10)

Experimentally Determined Recombination Data

Location

3-42

(FlyBase, 2016)

3-36.5

(Comeron et al., 2012)

3-47.0 +/- 0.9

(Shearn et al., 1978)

3-47.0

Left of (cM)

Right of (cM)

Notes

3-⁴² Based on mapping of mnd.

Stocks and Reagents

Stocks (9)

Bloomington

54560

y¹ w^*; Mi{MIC}mnd^MI10479

20091

y¹ w^67c23; P{EPgy2}mnd^EY00526

12791

w¹¹¹⁸; P{GT1}mnd^BG01434/TM3, Sb¹ Ser¹

62207

y¹ sc^* v¹ sev²¹; P{TRiP.HMC05214}attP40

9000

y¹ w^*; mnd¹ e¹/TM3, Ser¹, y⁺

Kyoto

104442

w^*; P{GawB}mnd^NP3293 / TM6, Sb¹ Tb¹

111492

y^d2 w¹¹¹⁸ P{ey-FLP.N}2 P{5xglBS-lacZ.38-1}TPN1; P{GT1}mnd^BG01434 P{neoFRT}80B/TM6B, P{Car20y}TPN1, Tb¹

VDRC

v110217

P{KK102686}VIE-260B

v42485

w¹¹¹⁸; P{GD453}v42485

Genomic Clones (18)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (50)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

LD25378

Other clones

MIP16009

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0002778

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0002778

GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents

39625

Antibody Information

Laboratory Generated Antibodies

polyclonal

(Manière et al., 2016)

Commercially Available Antibodies

Other Information

Relationship to Other Genes

Source for database identify of

Source for identity of: mnd CG3297

(Bayraktaroglu, 1999.11)

Source for identity of: mnd l(3)SG29

(Shearn, 1995.5.3)

Source for database merge of

Source for merge of: l(3)ds5 l(3)SG29

(Shearn, 1995.5.3)

Additional comments

Interallelic complementation not observed; heteroallelic combinations exhibit phenotypes intermediate between those of the two homozygotes.

Other Comments

The fat body may respond to amino acid uptake by the mnd transporter by secreting a factor that is required for imaginal disc maturation and proliferation.

(Martin et al., 2000)

Origin and Etymology

Discoverer

Etymology

Identification

External Crossreferences and Linkouts ( 62 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

39625

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Q9Y1A7

Other crossreferences

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0002778

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0002778

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

mnd_1
mnd_2

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG3297

Flygut - An atlas of the Drosophila adult midgut

FBgn0002778

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

205599

GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents

39625

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

InterPro - A database of protein families, domains and functional sites

Amino acid/polyamine transporter I

KEGG Genes - Molecular building blocks of life in the genomic space.

Dmel_CG3297

modMine - A data warehouse for the modENCODE project

FBgn0002778

Linkouts

BioGRID - A database of protein and genetic interactions.

64949

DroID - A comprehensive database of gene and protein interactions.

FBgn0002778

DRSC - Results frm RNAi screens

FBgn0002778

FLIGHT - Cell culture data for RNAi and other high-throughput technologies

FBgn0002778

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

CG3297-RB

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0002778

FlyMine - An integrated database for Drosophila genomics

FBgn0002778

InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.

39625

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Synonyms and Secondary IDs (13)

Reported As

Symbol Synonym

CG3297

(Paik et al., 2017, Limmer et al., 2014, Keleman et al., 2009.8.5, Perkins et al., 2009, Reynolds et al., 2009, Augustin et al., 2007)

Mnd

(Manière et al., 2020, Aboudhiaf et al., 2018)

SG29

(Levine et al., 1997)

l(3)B5

l(3)SG29

l(3)ds-5

(Cohen, 1993)

l(3)ds5

l(3)o52

(Shearn et al., 1978)

mnd

(Hung et al., 2020, Mishra et al., 2020, Meltzer et al., 2019, Paik et al., 2017, Ballard et al., 2010, Buffin and Gho, 2010, Christensen et al., 2009.7.22, Reynolds et al., 2009, Christensen et al., 2008.4.15, Gilchrist et al., 2008, McGraw et al., 2008, Augustin et al., 2007, Romero-Calderon et al., 2007, Yi et al., 2007, Flatt et al., 2005, Jordan et al., 2005)

Name Synonyms

Minidiscs

(Weiler et al., 2017, Reynolds et al., 2009)

minidiscs

(Featherstone, 2011, Ballard et al., 2010, Buffin and Gho, 2010, Augustin et al., 2007, Morozova et al., 2006, Flatt et al., 2005, Jordan et al., 2005)

minidisks

(McGraw et al., 2008)

Secondary FlyBase IDs

FBgn0002474
FBgn0004717

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

References (76)

The following external sites may use different assemblies or annotations than FlyBase.

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