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Gene Dmel\mor

General Information
Symbol	Dmel\mor	Species	D. melanogaster
Name	moira	Annotation symbol	CG18740
Feature type	protein_coding_gene	FlyBase ID	FBgn0002783
Gene Model Status	Current	Stock availability	7 publicly available
Also Known As	BAP155, Moira
Genomic Location
Chromosome (arm)	3R	Recombination map	3-58.1
Cytogenetic map	89A8-89A11	Sequence location	3R:11,793,856..11,798,636 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene moira is referred to in FlyBase by the symbol Dmel\mor (CG18740, FBgn0002783). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: protein binding. There is experimental evidence that it is involved in the biological process: imaginal disc-derived wing margin morphogenesis; negative regulation of S phase of mitotic cell cycle; imaginal disc-derived wing vein morphogenesis; imaginal disc-derived wing vein specification; positive regulation of transcription, DNA-dependent; imaginal disc-derived leg morphogenesis; neurogenesis. 28 alleles are reported. The phenotypes of these alleles are annotated with: midgut constriction 2; ventral nerve cord commissure; eye; embryonic head; macrochaeta; presumptive embryonic/larval peripheral nervous system; midgut constriction 1; wing. It has 2 annotated transcripts and 2 annotated polypeptides. Protein features are: BRCT domain; Homeodomain-like; SANT domain; SANT/Myb domain; SWIRM domain; Winged helix-turn-helix transcription repressor DNA-binding domain. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of moderate expression. Peak expression observed within 00-12 hour embryonic stages. Summary of FlyAtlas Anatomical Expression Data: Nearly all larval and adult tissues/organs expressed at moderate levels. Expression at high levels in the following post-embryonic organs or tissues: larval central nervous system, adult ovary. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, larval/adult salivary gland, larval trachea, adult spermathecae, adult male accessory gland, larval/adult carcass. Comments on Affy2 ProbeSet: ProbeSet 1640418_at completely aligns to an exonic region common to each of the 2 FlyBase-annotated transcript isoforms of mor. Gene sequence location is 3R:11793856..11798636.
User Contributed Data
	Beta version, feedback welcome
External Summaries
Phenotypic Description from the Red Book (Lindsley & Zimm 1992)
Gene/Allele symbols may differ from current usage	mor: moira (J.A. Kennison) Isolated as a dominant suppressor of the antenna-to-leg transformation in a Pc2 AntpNs double heterozygote. Strongly suppresses the antennal transformation in an AntpNs heterozygote, but does not suppress the antennal transformation in a strain containing a heat-shock driven Antennapedia cDNA. Also behaves as a dominant suppressor of Pc and Pcl mutations. All alleles associated with a common recessive embryonic lethality. Mitotic clones induced during larval growth lead to transformation of haltere tissue to wing tissue. Ubx130/mor has low frequency of haltere to wing transformation.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 89A8-89A11   Limits computationally determined from genome sequence between P{PZ}blp01618 and P{PZ}gish04895&P{EP}EP3171
Experimentally Determined Cytological Location
Cytogenetic map Notes References 89B-89B     (Zak, 1999.1.28) 89B-89B     (Crosby, 1997.11.10) 88E9-88F2   (determined by in situ hybridisation)   (Papoulas et al., 1998) 89-89     (Gellon et al., 1997) 88F9-89B4   Location from complementation analysis with deficiency and duplication chromosomes (details unspecified).   (Kennison and Tamkun, 1988)
Experimentally Determined Recombination Data
Location	3-58.1 (Kennison and Tamkun, 1988) 3- (Papoulas, 1998.6.9)
Left of (cM)	Sb cu (Brumby et al., 2004)
Right of (cM)	sr (Brumby et al., 2004) jvl
Notes	Based on 18 recombinants between jvl and Sbsbd-2.
Gene Model & Products
Please see the GBrowse view of Dmel\mor for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) mor-RA FBtr0083238  NM_079649   3984   1209 mor-RB FBtr0302550  NM_001202301   3792   1145
Additional Transcript Data & Comments
Reported size (kB)	4.5 (northern blot) (Crosby et al., 1999)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein mor-PA   FBpp0082692   131.4   1209   5.47     NP_524373   AAF55259 mor-PB   FBpp0291706   124.8   1145   5.35     NP_001189230   ADV37321
Additional Polypeptide Data & Comments
Reported size (kDa)	1209 (aa) (Papoulas et al., 1998) 1189 (aa); 170 (kD observed) (Crosby et al., 1999)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • SANT/Myb domain (IPR001005) SWIRM domain (IPR007526) Homeodomain-like (IPR009057) BRCT domain (IPR001357) SANT domain (IPR017884) Winged helix-turn-helix DNA-binding domain (IPR011991)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA201832   AA202553   AA202648   AA203034   AA246990   AA247002   AA390769   AA390799   AA391038   AA391189   AA391750   AA392315   AA393011   AA438344   AA439053   AA441011   AA536257   AA536616   AA541038   AA696096   AA820139   AA820289   AA820290   AA820402   AA820407   AA820459   AA940888   AA940893   AA941208   AA941251   AA948788   AA949140   AA949851   AA949961   AA951481   AE014297 AAF55259   AE014297 ADV37321   AF033823 AAD12718   AF071502 AAC28454   AF124375 AAD17318   AI260515   AI260987   AI294628   AI403003   AI456208   AI512956   AI513631   AI515334   AI516685   AI518349   AI519486   AI519547   AI533343   AI542212   AI542799   AI542901   AI542994   AI546628   AW941613   AY118495 AAM49864   BG635827   BG636780   BG637449   BI162023   BI162024   BI162297   BI169165   BI229710   BI231224   BI234501   BI352595   BI355379   BI356589   BI362319   BI362878   BI363269   BI371387   BI373939   BI374579   BI375320   BI633281   BI638344   BI638917   BT031130   CK132862   CK134011   CK659118   CK660121   CO156603   CO187225   CO189474   CO276744   CO277929   CO280303   CO293737   CO294187   CO295007   CO295919   CO302366   CO307263   CO308079   CO310534   CO313666   CO317443   EC059010   EC066083   EC075581   EC079719   EC079949   EC080430   EC081875   EC087058   EC087571   EC200076   EC206799   EC209926   EC210476   EC212637   EC213081   EC226881   EC232189   EC233850   EC247583   EC250811   EL871610   EL873794   EL873795
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q9VF03 Q7KND4 Q8MSY3 Q7KPY3
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage 1 -- 3   organism   (Fisher et al., 2012) Comment:maternally deposited embryonic stage 4 -- 6   organism | ubiquitous   (Fisher et al., 2012) embryonic stage 7 -- 8   antennal anlage   (Fisher et al., 2012) Comment:reported as procephalic ectoderm anlage central brain anlage   (Fisher et al., 2012) Comment:reported as procephalic ectoderm anlage dorsal head epidermis anlage   (Fisher et al., 2012) Comment:reported as procephalic ectoderm anlage visual anlage   (Fisher et al., 2012) Comment:reported as procephalic ectoderm anlage anterior endoderm anlage   (Fisher et al., 2012) dorsal ectoderm   (Fisher et al., 2012) head mesoderm   (Fisher et al., 2012) hindgut anlage   (Fisher et al., 2012) organism | ubiquitous   (Fisher et al., 2012) posterior endoderm   (Fisher et al., 2012) trunk mesoderm   (Fisher et al., 2012) ventral ectoderm   (Fisher et al., 2012) embryonic stage 9 -- 10   anterior endoderm   (Fisher et al., 2012) central brain primordium   (Fisher et al., 2012) foregut primordium   (Fisher et al., 2012) head mesoderm   (Fisher et al., 2012) inclusive hindgut primordium   (Fisher et al., 2012) organism | ubiquitous   (Fisher et al., 2012) posterior endoderm   (Fisher et al., 2012) trunk mesoderm   (Fisher et al., 2012) ventral nerve cord primordium   (Fisher et al., 2012) embryonic stage 11 -- 12   anterior midgut primordium   (Fisher et al., 2012) central brain primordium   (Fisher et al., 2012) embryonic central brain glial cell   (Fisher et al., 2012) embryonic central brain neuron   (Fisher et al., 2012) head mesoderm   (Fisher et al., 2012) lateral cord glial cell   (Fisher et al., 2012) lateral cord neuron   (Fisher et al., 2012) organism | ubiquitous   (Fisher et al., 2012) posterior midgut primordium   (Fisher et al., 2012) trunk mesoderm   (Fisher et al., 2012) ventral nerve cord primordium   (Fisher et al., 2012) embryonic stage 13 -- 16   embryonic brain   (Fisher et al., 2012) embryonic/larval nervous system   (Fisher et al., 2012) gonad   (Fisher et al., 2012) organism | faint & ubiquitous   (Fisher et al., 2012) ventral nerve cord   (Fisher et al., 2012) northern blot Stage Tissue/Position (including subcellular localization) Reference embryonic stage | early   organism | ubiquitous   (Crosby et al., 1999) embryonic stage -- pupal stage     (Crosby et al., 1999) embryonic stage 9 -- 17   embryonic/larval midgut   (Crosby et al., 1999) embryonic/larval hindgut   (Crosby et al., 1999) ventral nerve cord   (Crosby et al., 1999) embryonic brain   (Crosby et al., 1999) adult stage | female     (Crosby et al., 1999) adult stage | male     (Crosby et al., 1999)   unfertilized egg   (Crosby et al., 1999)
Additional Descriptive Data
	mor transcripts are detected by northern blot at 0-4hr of embryogenesis, reach a peak in 4-8hr embryos and decline until the 2nd instar larval stage. The are expressed also in third instar larvae, pupae, and adult males and females. mor transcripts are ubiquitously expressed in early embryos as assayed by in situ hybridization. They are enriched in the CNS, midgut and hindgut of older embryos. (Crosby et al., 1999)
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
immunolocalization Stage Tissue/Position (including subcellular localization) Reference embryonic stage | early   organism | ubiquitous   (Crosby et al., 1999) embryonic stage 9 -- 17   embryonic/larval hindgut   (Crosby et al., 1999) embryonic/larval midgut   (Crosby et al., 1999) embryonic brain   (Crosby et al., 1999) ventral nerve cord   (Crosby et al., 1999)
Additional Descriptive Data
	mor protein is ubiquitously expressed in early embryos. It is enriched in the CNS, midgut and hindgut of older embryos. (Crosby et al., 1999)
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
brahma complex inferred from direct assay (Kal et al., 2000) nucleus inferred from direct assay (Mohrmann et al., 2004)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Nearly all larval and adult tissues/organs expressed at moderate levels. Expression at high levels in the following post-embryonic organs or tissues: larval central nervous system, adult ovary. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, larval/adult salivary gland, larval trachea, adult spermathecae, adult male accessory gland, larval/adult carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    698.575 Larval Midgut    135.4 Larval Hindgut    232.3 Larval Malpighian Tubules    174.5 Larval Fat Body    154.4 Larval Salivary Gland    489 Larval Trachea    420.375 Larval Carcass    227.225 Adult Head    158 Adult Eye    160.875 Adult Brain    276.8 Adult Thoracic-Abdominal Ganglion    254.7 Adult Crop    162.1 Adult Midgut    104.5 Adult Hindgut    140.3 Adult Malpighian Tubules    186.7 Adult Fat Body    110.3 Adult Salivary Gland    374.2 Adult Heart    108.225 Adult VirginFemale Spermatheca    207.8 Adult InseminatedFemale Spermatheca    236.2 Adult Ovary    729.8 Adult Testis    76.9 Adult Male Accessory Gland    349.8 Adult Carcass    131.9 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System  (698.575) Larval Midgut    135.4 Larval Hindgut    232.3 Larval Malpighian Tubules    174.5 Larval Fat Body    154.4 Larval Salivary Gland    489 Larval Trachea    420.375 Larval Carcass    227.225 Adult Head    158 Adult Eye    160.875 Adult Brain    276.8 Adult Thoracic-Abdominal Ganglion    254.7 Adult Crop    162.1 Adult Midgut    104.5 Adult Hindgut    140.3 Adult Malpighian Tubules    186.7 Adult Fat Body    110.3 Adult Salivary Gland    374.2 Adult Heart    108.225 Adult VirginFemale Spermatheca    207.8 Adult InseminatedFemale Spermatheca    236.2 Adult Ovary  (729.8) Adult Testis    76.9 Adult Male Accessory Gland    349.8 Adult Carcass    131.9 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    698.575 Larval Midgut    135.4 Larval Hindgut    232.3 Larval Malpighian Tubules    174.5 Larval Fat Body    154.4 Larval Salivary Gland    489 Larval Trachea    420.375 Larval Carcass    227.225 Adult Head    158 Adult Eye    160.875 Adult Brain    276.8 Adult Thoracic-Abdominal Ganglion    254.7 Adult Crop    162.1 Adult Midgut    104.5 Adult Hindgut    140.3 Adult Malpighian Tubules    186.7 Adult Fat Body    110.3 Adult Salivary Gland    374.2 Adult Heart    108.225 Adult VirginFemale Spermatheca    207.8 Adult InseminatedFemale Spermatheca    236.2 Adult Ovary    729.8 Adult Testis    76.9 Adult Male Accessory Gland    349.8 Adult Carcass    131.9 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    698.575 Larval Midgut    135.4 Larval Hindgut    232.3 Larval Malpighian Tubules    174.5 Larval Fat Body    154.4 Larval Salivary Gland    489 Larval Trachea    420.375 Larval Carcass    227.225 Adult Head    158 Adult Eye    160.875 Adult Brain    276.8 Adult Thoracic-Abdominal Ganglion    254.7 Adult Crop    162.1 Adult Midgut    104.5 Adult Hindgut    140.3 Adult Malpighian Tubules    186.7 Adult Fat Body    110.3 Adult Salivary Gland    374.2 Adult Heart    108.225 Adult VirginFemale Spermatheca    207.8 Adult InseminatedFemale Spermatheca    236.2 Adult Ovary    729.8 Adult Testis    76.9 Adult Male Accessory Gland    349.8 Adult Carcass    131.9 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    698.575 Larval Midgut    135.4 Larval Hindgut    232.3 Larval Malpighian Tubules    174.5 Larval Fat Body    154.4 Larval Salivary Gland    489 Larval Trachea    420.375 Larval Carcass    227.225 Adult Head    158 Adult Eye    160.875 Adult Brain    276.8 Adult Thoracic-Abdominal Ganglion    254.7 Adult Crop    162.1 Adult Midgut    104.5 Adult Hindgut    140.3 Adult Malpighian Tubules    186.7 Adult Fat Body    110.3 Adult Salivary Gland    374.2 Adult Heart    108.225 Adult VirginFemale Spermatheca    207.8 Adult InseminatedFemale Spermatheca    236.2 Adult Ovary    729.8 Adult Testis    76.9 Adult Male Accessory Gland    349.8 Adult Carcass    131.9 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System  698.575 Larval Midgut    135.4 Larval Hindgut    232.3 Larval Malpighian Tubules    174.5 Larval Fat Body    154.4 Larval Salivary Gland    489 Larval Trachea    420.375 Larval Carcass    227.225 Adult Head    158 Adult Eye    160.875 Adult Brain    276.8 Adult Thoracic-Abdominal Ganglion    254.7 Adult Crop    162.1 Adult Midgut    104.5 Adult Hindgut    140.3 Adult Malpighian Tubules    186.7 Adult Fat Body    110.3 Adult Salivary Gland    374.2 Adult Heart    108.225 Adult VirginFemale Spermatheca    207.8 Adult InseminatedFemale Spermatheca    236.2 Adult Ovary  729.8 Adult Testis    76.9 Adult Male Accessory Gland    349.8 Adult Carcass    131.9 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    698.575 Larval Midgut    135.4 Larval Hindgut    232.3 Larval Malpighian Tubules    174.5 Larval Fat Body    154.4 Larval Salivary Gland    489 Larval Trachea    420.375 Larval Carcass    227.225 Adult Head    158 Adult Eye    160.875 Adult Brain    276.8 Adult Thoracic-Abdominal Ganglion    254.7 Adult Crop    162.1 Adult Midgut    104.5 Adult Hindgut    140.3 Adult Malpighian Tubules    186.7 Adult Fat Body    110.3 Adult Salivary Gland    374.2 Adult Heart    108.225 Adult VirginFemale Spermatheca    207.8 Adult InseminatedFemale Spermatheca    236.2 Adult Ovary    729.8 Adult Testis    76.9 Adult Male Accessory Gland    349.8 Adult Carcass    131.9 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    698.575 Larval Midgut    135.4 Larval Hindgut    232.3 Larval Malpighian Tubules    174.5 Larval Fat Body    154.4 Larval Salivary Gland    489 Larval Trachea    420.375 Larval Carcass    227.225 Adult Head    158 Adult Eye    160.875 Adult Brain    276.8 Adult Thoracic-Abdominal Ganglion    254.7 Adult Crop    162.1 Adult Midgut    104.5 Adult Hindgut    140.3 Adult Malpighian Tubules    186.7 Adult Fat Body    110.3 Adult Salivary Gland    374.2 Adult Heart    108.225 Adult VirginFemale Spermatheca    207.8 Adult InseminatedFemale Spermatheca    236.2 Adult Ovary    729.8 Adult Testis    76.9 Adult Male Accessory Gland    349.8 Adult Carcass    131.9 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    158   NA  Eye    160.875   NA  Brain    276.8   698.575  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    254.7   NA  Crop    162.1   135.4  Midgut    104.5   232.3  Hindgut    140.3   174.5  Malpighian Tubules    186.7   154.4  Fat Body    110.3   489  Salivary Gland    374.2   NA  Heart    108.225   420.375  Trachea    NA   NA  VirginFemale Spermatheca    207.8   NA  InseminatedFemale Spermatheca    236.2   NA  Ovary    729.8   NA  Testis    76.9   NA  Male Accessory Gland    349.8   227.225  Carcass    131.9 FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    76 central nervous system, larvae L3    153 central nervous system, pupae P8    44 head, virgin 1-day female    17 head, virgin 4-day female    18 head, virgin 20-day female    14 head, mated 1-day female    21 head, mated 4-day female    17 head, mated 20-day female    14 head, mated 1-day male    21 head, mated 4-day male    26 head, mated 20-day male    27 salivary gland, larvae L3 wandering    4 salivary gland, white prepupae    9 digestive system, larvae L3 wandering    17 digestive system, 1-day adult    12 digestive system, 4-day adult    18 digestive system, 20-day adult    15 fat body, larvae L3 wandering    11 fat body, white prepupae    25 fat body, pupae P8    27 carcass, larvae L3 wandering    80 carcass, 1-day adult    12 carcass, 4-day adult    19 carcass, 20-day adult    15 ovary, virgin 4-day female    145 ovary, mated 4-day female    229 testis, mated 4-day male    14 accessory gland, mated 4-day male    15 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (76) central nervous system, larvae L3  (153) central nervous system, pupae P8  (44) head, virgin 1-day female    17 head, virgin 4-day female    18 head, virgin 20-day female    14 head, mated 1-day female    21 head, mated 4-day female    17 head, mated 20-day female    14 head, mated 1-day male    21 head, mated 4-day male  26 head, mated 20-day male  (27) salivary gland, larvae L3 wandering    4 salivary gland, white prepupae    9 digestive system, larvae L3 wandering    17 digestive system, 1-day adult    12 digestive system, 4-day adult    18 digestive system, 20-day adult    15 fat body, larvae L3 wandering    11 fat body, white prepupae    25 fat body, pupae P8  (27) carcass, larvae L3 wandering  (80) carcass, 1-day adult    12 carcass, 4-day adult    19 carcass, 20-day adult    15 ovary, virgin 4-day female  (145) ovary, mated 4-day female  (229) testis, mated 4-day male    14 accessory gland, mated 4-day male    15 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    76 central nervous system, larvae L3  (153) central nervous system, pupae P8    44 head, virgin 1-day female    17 head, virgin 4-day female    18 head, virgin 20-day female    14 head, mated 1-day female    21 head, mated 4-day female    17 head, mated 20-day female    14 head, mated 1-day male    21 head, mated 4-day male    26 head, mated 20-day male    27 salivary gland, larvae L3 wandering    4 salivary gland, white prepupae    9 digestive system, larvae L3 wandering    17 digestive system, 1-day adult    12 digestive system, 4-day adult    18 digestive system, 20-day adult    15 fat body, larvae L3 wandering    11 fat body, white prepupae    25 fat body, pupae P8    27 carcass, larvae L3 wandering    80 carcass, 1-day adult    12 carcass, 4-day adult    19 carcass, 20-day adult    15 ovary, virgin 4-day female  (145) ovary, mated 4-day female  (229) testis, mated 4-day male    14 accessory gland, mated 4-day male    15 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    76 central nervous system, larvae L3    153 central nervous system, pupae P8    44 head, virgin 1-day female    17 head, virgin 4-day female    18 head, virgin 20-day female    14 head, mated 1-day female    21 head, mated 4-day female    17 head, mated 20-day female    14 head, mated 1-day male    21 head, mated 4-day male    26 head, mated 20-day male    27 salivary gland, larvae L3 wandering    4 salivary gland, white prepupae    9 digestive system, larvae L3 wandering    17 digestive system, 1-day adult    12 digestive system, 4-day adult    18 digestive system, 20-day adult    15 fat body, larvae L3 wandering    11 fat body, white prepupae    25 fat body, pupae P8    27 carcass, larvae L3 wandering    80 carcass, 1-day adult    12 carcass, 4-day adult    19 carcass, 20-day adult    15 ovary, virgin 4-day female    145 ovary, mated 4-day female    229 testis, mated 4-day male    14 accessory gland, mated 4-day male    15 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    76 central nervous system, larvae L3    153 central nervous system, pupae P8    44 head, virgin 1-day female    17 head, virgin 4-day female    18 head, virgin 20-day female    14 head, mated 1-day female    21 head, mated 4-day female    17 head, mated 20-day female    14 head, mated 1-day male    21 head, mated 4-day male    26 head, mated 20-day male    27 salivary gland, larvae L3 wandering    4 salivary gland, white prepupae    9 digestive system, larvae L3 wandering    17 digestive system, 1-day adult    12 digestive system, 4-day adult    18 digestive system, 20-day adult    15 fat body, larvae L3 wandering    11 fat body, white prepupae    25 fat body, pupae P8    27 carcass, larvae L3 wandering    80 carcass, 1-day adult    12 carcass, 4-day adult    19 carcass, 20-day adult    15 ovary, virgin 4-day female    145 ovary, mated 4-day female    229 testis, mated 4-day male    14 accessory gland, mated 4-day male    15 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (76) central nervous system, larvae L3  (153) central nervous system, pupae P8  (44) head, virgin 1-day female    17 head, virgin 4-day female    18 head, virgin 20-day female    14 head, mated 1-day female    21 head, mated 4-day female    17 head, mated 20-day female    14 head, mated 1-day male    21 head, mated 4-day male  26 head, mated 20-day male  27 salivary gland, larvae L3 wandering    4 salivary gland, white prepupae    9 digestive system, larvae L3 wandering    17 digestive system, 1-day adult    12 digestive system, 4-day adult    18 digestive system, 20-day adult    15 fat body, larvae L3 wandering    11 fat body, white prepupae    25 fat body, pupae P8  27 carcass, larvae L3 wandering  (80) carcass, 1-day adult    12 carcass, 4-day adult    19 carcass, 20-day adult    15 ovary, virgin 4-day female  (145) ovary, mated 4-day female  (229) testis, mated 4-day male    14 accessory gland, mated 4-day male    15 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    76 central nervous system, larvae L3  (153) central nervous system, pupae P8    44 head, virgin 1-day female    17 head, virgin 4-day female    18 head, virgin 20-day female    14 head, mated 1-day female    21 head, mated 4-day female    17 head, mated 20-day female    14 head, mated 1-day male    21 head, mated 4-day male    26 head, mated 20-day male    27 salivary gland, larvae L3 wandering    4 salivary gland, white prepupae    9 digestive system, larvae L3 wandering    17 digestive system, 1-day adult    12 digestive system, 4-day adult    18 digestive system, 20-day adult    15 fat body, larvae L3 wandering    11 fat body, white prepupae    25 fat body, pupae P8    27 carcass, larvae L3 wandering    80 carcass, 1-day adult    12 carcass, 4-day adult    19 carcass, 20-day adult    15 ovary, virgin 4-day female  (145) ovary, mated 4-day female  (229) testis, mated 4-day male    14 accessory gland, mated 4-day male    15 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    76 central nervous system, larvae L3    153 central nervous system, pupae P8    44 head, virgin 1-day female    17 head, virgin 4-day female    18 head, virgin 20-day female    14 head, mated 1-day female    21 head, mated 4-day female    17 head, mated 20-day female    14 head, mated 1-day male    21 head, mated 4-day male    26 head, mated 20-day male    27 salivary gland, larvae L3 wandering    4 salivary gland, white prepupae    9 digestive system, larvae L3 wandering    17 digestive system, 1-day adult    12 digestive system, 4-day adult    18 digestive system, 20-day adult    15 fat body, larvae L3 wandering    11 fat body, white prepupae    25 fat body, pupae P8    27 carcass, larvae L3 wandering    80 carcass, 1-day adult    12 carcass, 4-day adult    19 carcass, 20-day adult    15 ovary, virgin 4-day female    145 ovary, mated 4-day female    229 testis, mated 4-day male    14 accessory gland, mated 4-day male    15 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of moderate expression. Peak expression observed within 00-12 hour embryonic stages. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    127 embryo 02-04hr    213 embryo 04-06hr    192 embryo 06-08hr    169 embryo 08-10hr    134 embryo 10-12hr    92 embryo 12-14hr    73 embryo 14-16hr    68 embryo 16-18hr    45 embryo 18-20hr    24 embryo 20-22hr    50 embryo 22-24hr    45 larva L1    19 larva L2    18 larva L3 12hr old    14 larva L3 puffstage 1-2    19 larva L3 puffstage 3-6    30 larva L3 puffstage 7-9    33 white prepupae new    36 white prepupae 12hr    40 white prepupae 24hr    55 pupae 2d postWPP    25 pupae 3d postWPP    10 pupae 4d postWPP    7 adult male 01day    10 adult male 05day    13 adult male 30day    13 adult female 01day    38 adult female 05day    68 adult female 30day    70 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (127) embryo 02-04hr  (213) embryo 04-06hr  (192) embryo 06-08hr  (169) embryo 08-10hr  (134) embryo 10-12hr  (92) embryo 12-14hr  (73) embryo 14-16hr  (68) embryo 16-18hr  (45) embryo 18-20hr    24 embryo 20-22hr  (50) embryo 22-24hr  (45) larva L1    19 larva L2    18 larva L3 12hr old    14 larva L3 puffstage 1-2    19 larva L3 puffstage 3-6  (30) larva L3 puffstage 7-9  (33) white prepupae new  (36) white prepupae 12hr  (40) white prepupae 24hr  (55) pupae 2d postWPP    25 pupae 3d postWPP    10 pupae 4d postWPP    7 adult male 01day    10 adult male 05day    13 adult male 30day    13 adult female 01day  (38) adult female 05day  (68) adult female 30day  (70) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr  (127) embryo 02-04hr  (213) embryo 04-06hr  (192) embryo 06-08hr  (169) embryo 08-10hr  (134) embryo 10-12hr    92 embryo 12-14hr    73 embryo 14-16hr    68 embryo 16-18hr    45 embryo 18-20hr    24 embryo 20-22hr    50 embryo 22-24hr    45 larva L1    19 larva L2    18 larva L3 12hr old    14 larva L3 puffstage 1-2    19 larva L3 puffstage 3-6    30 larva L3 puffstage 7-9    33 white prepupae new    36 white prepupae 12hr    40 white prepupae 24hr    55 pupae 2d postWPP    25 pupae 3d postWPP    10 pupae 4d postWPP    7 adult male 01day    10 adult male 05day    13 adult male 30day    13 adult female 01day    38 adult female 05day    68 adult female 30day    70 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    127 embryo 02-04hr    213 embryo 04-06hr    192 embryo 06-08hr    169 embryo 08-10hr    134 embryo 10-12hr    92 embryo 12-14hr    73 embryo 14-16hr    68 embryo 16-18hr    45 embryo 18-20hr    24 embryo 20-22hr    50 embryo 22-24hr    45 larva L1    19 larva L2    18 larva L3 12hr old    14 larva L3 puffstage 1-2    19 larva L3 puffstage 3-6    30 larva L3 puffstage 7-9    33 white prepupae new    36 white prepupae 12hr    40 white prepupae 24hr    55 pupae 2d postWPP    25 pupae 3d postWPP    10 pupae 4d postWPP    7 adult male 01day    10 adult male 05day    13 adult male 30day    13 adult female 01day    38 adult female 05day    68 adult female 30day    70 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    127 embryo 02-04hr    213 embryo 04-06hr    192 embryo 06-08hr    169 embryo 08-10hr    134 embryo 10-12hr    92 embryo 12-14hr    73 embryo 14-16hr    68 embryo 16-18hr    45 embryo 18-20hr    24 embryo 20-22hr    50 embryo 22-24hr    45 larva L1    19 larva L2    18 larva L3 12hr old    14 larva L3 puffstage 1-2    19 larva L3 puffstage 3-6    30 larva L3 puffstage 7-9    33 white prepupae new    36 white prepupae 12hr    40 white prepupae 24hr    55 pupae 2d postWPP    25 pupae 3d postWPP    10 pupae 4d postWPP    7 adult male 01day    10 adult male 05day    13 adult male 30day    13 adult female 01day    38 adult female 05day    68 adult female 30day    70 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (127) embryo 02-04hr  (213) embryo 04-06hr  (192) embryo 06-08hr  (169) embryo 08-10hr  (134) embryo 10-12hr  (92) embryo 12-14hr  (73) embryo 14-16hr  (68) embryo 16-18hr  (45) embryo 18-20hr    24 embryo 20-22hr  (50) embryo 22-24hr  (45) larva L1    19 larva L2    18 larva L3 12hr old    14 larva L3 puffstage 1-2    19 larva L3 puffstage 3-6  30 larva L3 puffstage 7-9  (33) white prepupae new  (36) white prepupae 12hr  (40) white prepupae 24hr  (55) pupae 2d postWPP    25 pupae 3d postWPP    10 pupae 4d postWPP    7 adult male 01day    10 adult male 05day    13 adult male 30day    13 adult female 01day  (38) adult female 05day  (68) adult female 30day  (70) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr  127 embryo 02-04hr  (213) embryo 04-06hr  (192) embryo 06-08hr  (169) embryo 08-10hr  134 embryo 10-12hr    92 embryo 12-14hr    73 embryo 14-16hr    68 embryo 16-18hr    45 embryo 18-20hr    24 embryo 20-22hr    50 embryo 22-24hr    45 larva L1    19 larva L2    18 larva L3 12hr old    14 larva L3 puffstage 1-2    19 larva L3 puffstage 3-6    30 larva L3 puffstage 7-9    33 white prepupae new    36 white prepupae 12hr    40 white prepupae 24hr    55 pupae 2d postWPP    25 pupae 3d postWPP    10 pupae 4d postWPP    7 adult male 01day    10 adult male 05day    13 adult male 30day    13 adult female 01day    38 adult female 05day    68 adult female 30day    70 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    127 embryo 02-04hr    213 embryo 04-06hr    192 embryo 06-08hr    169 embryo 08-10hr    134 embryo 10-12hr    92 embryo 12-14hr    73 embryo 14-16hr    68 embryo 16-18hr    45 embryo 18-20hr    24 embryo 20-22hr    50 embryo 22-24hr    45 larva L1    19 larva L2    18 larva L3 12hr old    14 larva L3 puffstage 1-2    19 larva L3 puffstage 3-6    30 larva L3 puffstage 7-9    33 white prepupae new    36 white prepupae 12hr    40 white prepupae 24hr    55 pupae 2d postWPP    25 pupae 3d postWPP    10 pupae 4d postWPP    7 adult male 01day    10 adult male 05day    13 adult male 30day    13 adult female 01day    38 adult female 05day    68 adult female 30day    70 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    163 Schneider line 2 Sg4    87 embryonic 1182-4H    88 embryonic GM2    65 embryonic Kc167    41 embryonic S1    146 embryonic S3    86 leg disc CME L1    112 wing disc CME-W2    53 wing disc ML-DmD8    65 wing disc ML-DmD9    92 wing disc ML-DmD16-c3    132 wing disc ML-DmD21    85 wing disc ML-DmD32    101 haltere disc ML-DmD17-c3    119 eye-antennal disc ML-DmD11    68 antennal disc ML-DmD20-c5    61 mixed discs ML-DmD4-c1    107 CNS ML-DmBG1-c1    99 CNS ML-DmBG2-c2    62 tumorous blood cells mbn2    104 ovary fGS/OSS    163 ovary OSC    187 ovary OSS    141 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (163) Schneider line 2 Sg4  (87) embryonic 1182-4H  (88) embryonic GM2  (65) embryonic Kc167  (41) embryonic S1  (146) embryonic S3  (86) leg disc CME L1  (112) wing disc CME-W2  (53) wing disc ML-DmD8  (65) wing disc ML-DmD9  (92) wing disc ML-DmD16-c3  (132) wing disc ML-DmD21  (85) wing disc ML-DmD32  (101) haltere disc ML-DmD17-c3  (119) eye-antennal disc ML-DmD11  (68) antennal disc ML-DmD20-c5  (61) mixed discs ML-DmD4-c1  (107) CNS ML-DmBG1-c1  (99) CNS ML-DmBG2-c2  (62) tumorous blood cells mbn2  (104) ovary fGS/OSS  (163) ovary OSC  (187) ovary OSS  (141) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+  (163) Schneider line 2 Sg4    87 embryonic 1182-4H    88 embryonic GM2    65 embryonic Kc167    41 embryonic S1  (146) embryonic S3    86 leg disc CME L1  (112) wing disc CME-W2    53 wing disc ML-DmD8    65 wing disc ML-DmD9    92 wing disc ML-DmD16-c3  (132) wing disc ML-DmD21    85 wing disc ML-DmD32  101 haltere disc ML-DmD17-c3  (119) eye-antennal disc ML-DmD11    68 antennal disc ML-DmD20-c5    61 mixed discs ML-DmD4-c1  107 CNS ML-DmBG1-c1    99 CNS ML-DmBG2-c2    62 tumorous blood cells mbn2  104 ovary fGS/OSS  (163) ovary OSC  (187) ovary OSS  (141) Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    163 Schneider line 2 Sg4    87 embryonic 1182-4H    88 embryonic GM2    65 embryonic Kc167    41 embryonic S1    146 embryonic S3    86 leg disc CME L1    112 wing disc CME-W2    53 wing disc ML-DmD8    65 wing disc ML-DmD9    92 wing disc ML-DmD16-c3    132 wing disc ML-DmD21    85 wing disc ML-DmD32    101 haltere disc ML-DmD17-c3    119 eye-antennal disc ML-DmD11    68 antennal disc ML-DmD20-c5    61 mixed discs ML-DmD4-c1    107 CNS ML-DmBG1-c1    99 CNS ML-DmBG2-c2    62 tumorous blood cells mbn2    104 ovary fGS/OSS    163 ovary OSC    187 ovary OSS    141 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    163 Schneider line 2 Sg4    87 embryonic 1182-4H    88 embryonic GM2    65 embryonic Kc167    41 embryonic S1    146 embryonic S3    86 leg disc CME L1    112 wing disc CME-W2    53 wing disc ML-DmD8    65 wing disc ML-DmD9    92 wing disc ML-DmD16-c3    132 wing disc ML-DmD21    85 wing disc ML-DmD32    101 haltere disc ML-DmD17-c3    119 eye-antennal disc ML-DmD11    68 antennal disc ML-DmD20-c5    61 mixed discs ML-DmD4-c1    107 CNS ML-DmBG1-c1    99 CNS ML-DmBG2-c2    62 tumorous blood cells mbn2    104 ovary fGS/OSS    163 ovary OSC    187 ovary OSS    141 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (163) Schneider line 2 Sg4  (87) embryonic 1182-4H  (88) embryonic GM2  (65) embryonic Kc167  (41) embryonic S1  (146) embryonic S3  (86) leg disc CME L1  (112) wing disc CME-W2  (53) wing disc ML-DmD8  (65) wing disc ML-DmD9  (92) wing disc ML-DmD16-c3  (132) wing disc ML-DmD21  (85) wing disc ML-DmD32  (101) haltere disc ML-DmD17-c3  (119) eye-antennal disc ML-DmD11  (68) antennal disc ML-DmD20-c5  (61) mixed discs ML-DmD4-c1  (107) CNS ML-DmBG1-c1  (99) CNS ML-DmBG2-c2  (62) tumorous blood cells mbn2  (104) ovary fGS/OSS  (163) ovary OSC  (187) ovary OSS  (141) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+  (163) Schneider line 2 Sg4    87 embryonic 1182-4H    88 embryonic GM2    65 embryonic Kc167    41 embryonic S1  (146) embryonic S3    86 leg disc CME L1  112 wing disc CME-W2    53 wing disc ML-DmD8    65 wing disc ML-DmD9    92 wing disc ML-DmD16-c3  132 wing disc ML-DmD21    85 wing disc ML-DmD32  101 haltere disc ML-DmD17-c3  119 eye-antennal disc ML-DmD11    68 antennal disc ML-DmD20-c5    61 mixed discs ML-DmD4-c1  107 CNS ML-DmBG1-c1    99 CNS ML-DmBG2-c2    62 tumorous blood cells mbn2  104 ovary fGS/OSS  (163) ovary OSC  (187) ovary OSS  141 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    163 Schneider line 2 Sg4    87 embryonic 1182-4H    88 embryonic GM2    65 embryonic Kc167    41 embryonic S1    146 embryonic S3    86 leg disc CME L1    112 wing disc CME-W2    53 wing disc ML-DmD8    65 wing disc ML-DmD9    92 wing disc ML-DmD16-c3    132 wing disc ML-DmD21    85 wing disc ML-DmD32    101 haltere disc ML-DmD17-c3    119 eye-antennal disc ML-DmD11    68 antennal disc ML-DmD20-c5    61 mixed discs ML-DmD4-c1    107 CNS ML-DmBG1-c1    99 CNS ML-DmBG2-c2    62 tumorous blood cells mbn2    104 ovary fGS/OSS    163 ovary OSC    187 ovary OSS    141 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    77 cold shock, 4-day adult    53 heat shock, 4-day adult    52 Cadmium 50 mM 6 hrs, larvae L3    18 Cadmium 50 mM 12 hrs, larvae L3    12 Cadmium 50 mM 48 hrs, 4-day adult    65 Cadmium 100 mM 48 hrs, 4-day adult    147 Copper 0.5 mM 12 hrs, larvae L3    35 Copper 15 mM 48 hrs, 4-day adult    117 Zinc 5 mM 12 hrs, larvae L3    27 Zinc 4.5 mM 48 hrs, 4-day adult    46 Ethanol 2.5% 3 hrs, larvae L3    108 Ethanol 5% 3 hrs, larvae L3    15 Ethanol 10% 3 hrs, larvae L3    17 Caffeine 1.5 mg/ml 4 hrs, larvae L3    13 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    136 Caffeine 25 mg/ml 48 hrs, 4-day adult    77 Paraquat 5 mM 48 hrs, 4-day adult    103 Paraquat 10 mM 48 hrs, 4-day adult    68 Rotenone 2 μg 12 hrs, larvae L3    14 Rotenone 8 μg 12 hrs, larvae L3    17 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult  (77) cold shock, 4-day adult  (53) heat shock, 4-day adult  (52) Cadmium 50 mM 6 hrs, larvae L3    18 Cadmium 50 mM 12 hrs, larvae L3    12 Cadmium 50 mM 48 hrs, 4-day adult  (65) Cadmium 100 mM 48 hrs, 4-day adult  (147) Copper 0.5 mM 12 hrs, larvae L3  (35) Copper 15 mM 48 hrs, 4-day adult  (117) Zinc 5 mM 12 hrs, larvae L3  (27) Zinc 4.5 mM 48 hrs, 4-day adult  (46) Ethanol 2.5% 3 hrs, larvae L3  (108) Ethanol 5% 3 hrs, larvae L3    15 Ethanol 10% 3 hrs, larvae L3    17 Caffeine 1.5 mg/ml 4 hrs, larvae L3    13 Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (136) Caffeine 25 mg/ml 48 hrs, 4-day adult  (77) Paraquat 5 mM 48 hrs, 4-day adult  (103) Paraquat 10 mM 48 hrs, 4-day adult  (68) Rotenone 2 μg 12 hrs, larvae L3    14 Rotenone 8 μg 12 hrs, larvae L3    17 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    77 cold shock, 4-day adult    53 heat shock, 4-day adult    52 Cadmium 50 mM 6 hrs, larvae L3    18 Cadmium 50 mM 12 hrs, larvae L3    12 Cadmium 50 mM 48 hrs, 4-day adult    65 Cadmium 100 mM 48 hrs, 4-day adult  (147) Copper 0.5 mM 12 hrs, larvae L3    35 Copper 15 mM 48 hrs, 4-day adult  (117) Zinc 5 mM 12 hrs, larvae L3    27 Zinc 4.5 mM 48 hrs, 4-day adult    46 Ethanol 2.5% 3 hrs, larvae L3  (108) Ethanol 5% 3 hrs, larvae L3    15 Ethanol 10% 3 hrs, larvae L3    17 Caffeine 1.5 mg/ml 4 hrs, larvae L3    13 Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (136) Caffeine 25 mg/ml 48 hrs, 4-day adult    77 Paraquat 5 mM 48 hrs, 4-day adult  103 Paraquat 10 mM 48 hrs, 4-day adult    68 Rotenone 2 μg 12 hrs, larvae L3    14 Rotenone 8 μg 12 hrs, larvae L3    17 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    77 cold shock, 4-day adult    53 heat shock, 4-day adult    52 Cadmium 50 mM 6 hrs, larvae L3    18 Cadmium 50 mM 12 hrs, larvae L3    12 Cadmium 50 mM 48 hrs, 4-day adult    65 Cadmium 100 mM 48 hrs, 4-day adult    147 Copper 0.5 mM 12 hrs, larvae L3    35 Copper 15 mM 48 hrs, 4-day adult    117 Zinc 5 mM 12 hrs, larvae L3    27 Zinc 4.5 mM 48 hrs, 4-day adult    46 Ethanol 2.5% 3 hrs, larvae L3    108 Ethanol 5% 3 hrs, larvae L3    15 Ethanol 10% 3 hrs, larvae L3    17 Caffeine 1.5 mg/ml 4 hrs, larvae L3    13 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    136 Caffeine 25 mg/ml 48 hrs, 4-day adult    77 Paraquat 5 mM 48 hrs, 4-day adult    103 Paraquat 10 mM 48 hrs, 4-day adult    68 Rotenone 2 μg 12 hrs, larvae L3    14 Rotenone 8 μg 12 hrs, larvae L3    17 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    77 cold shock, 4-day adult    53 heat shock, 4-day adult    52 Cadmium 50 mM 6 hrs, larvae L3    18 Cadmium 50 mM 12 hrs, larvae L3    12 Cadmium 50 mM 48 hrs, 4-day adult    65 Cadmium 100 mM 48 hrs, 4-day adult    147 Copper 0.5 mM 12 hrs, larvae L3    35 Copper 15 mM 48 hrs, 4-day adult    117 Zinc 5 mM 12 hrs, larvae L3    27 Zinc 4.5 mM 48 hrs, 4-day adult    46 Ethanol 2.5% 3 hrs, larvae L3    108 Ethanol 5% 3 hrs, larvae L3    15 Ethanol 10% 3 hrs, larvae L3    17 Caffeine 1.5 mg/ml 4 hrs, larvae L3    13 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    136 Caffeine 25 mg/ml 48 hrs, 4-day adult    77 Paraquat 5 mM 48 hrs, 4-day adult    103 Paraquat 10 mM 48 hrs, 4-day adult    68 Rotenone 2 μg 12 hrs, larvae L3    14 Rotenone 8 μg 12 hrs, larvae L3    17 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult  (77) cold shock, 4-day adult  (53) heat shock, 4-day adult  (52) Cadmium 50 mM 6 hrs, larvae L3    18 Cadmium 50 mM 12 hrs, larvae L3    12 Cadmium 50 mM 48 hrs, 4-day adult  (65) Cadmium 100 mM 48 hrs, 4-day adult  (147) Copper 0.5 mM 12 hrs, larvae L3  (35) Copper 15 mM 48 hrs, 4-day adult  (117) Zinc 5 mM 12 hrs, larvae L3  27 Zinc 4.5 mM 48 hrs, 4-day adult  (46) Ethanol 2.5% 3 hrs, larvae L3  (108) Ethanol 5% 3 hrs, larvae L3    15 Ethanol 10% 3 hrs, larvae L3    17 Caffeine 1.5 mg/ml 4 hrs, larvae L3    13 Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (136) Caffeine 25 mg/ml 48 hrs, 4-day adult  (77) Paraquat 5 mM 48 hrs, 4-day adult  (103) Paraquat 10 mM 48 hrs, 4-day adult  (68) Rotenone 2 μg 12 hrs, larvae L3    14 Rotenone 8 μg 12 hrs, larvae L3    17 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    77 cold shock, 4-day adult    53 heat shock, 4-day adult    52 Cadmium 50 mM 6 hrs, larvae L3    18 Cadmium 50 mM 12 hrs, larvae L3    12 Cadmium 50 mM 48 hrs, 4-day adult    65 Cadmium 100 mM 48 hrs, 4-day adult  (147) Copper 0.5 mM 12 hrs, larvae L3    35 Copper 15 mM 48 hrs, 4-day adult  117 Zinc 5 mM 12 hrs, larvae L3    27 Zinc 4.5 mM 48 hrs, 4-day adult    46 Ethanol 2.5% 3 hrs, larvae L3  108 Ethanol 5% 3 hrs, larvae L3    15 Ethanol 10% 3 hrs, larvae L3    17 Caffeine 1.5 mg/ml 4 hrs, larvae L3    13 Caffeine 2.5 mg/ml 48 hrs, 4-day adult  136 Caffeine 25 mg/ml 48 hrs, 4-day adult    77 Paraquat 5 mM 48 hrs, 4-day adult  103 Paraquat 10 mM 48 hrs, 4-day adult    68 Rotenone 2 μg 12 hrs, larvae L3    14 Rotenone 8 μg 12 hrs, larvae L3    17 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    77 cold shock, 4-day adult    53 heat shock, 4-day adult    52 Cadmium 50 mM 6 hrs, larvae L3    18 Cadmium 50 mM 12 hrs, larvae L3    12 Cadmium 50 mM 48 hrs, 4-day adult    65 Cadmium 100 mM 48 hrs, 4-day adult    147 Copper 0.5 mM 12 hrs, larvae L3    35 Copper 15 mM 48 hrs, 4-day adult    117 Zinc 5 mM 12 hrs, larvae L3    27 Zinc 4.5 mM 48 hrs, 4-day adult    46 Ethanol 2.5% 3 hrs, larvae L3    108 Ethanol 5% 3 hrs, larvae L3    15 Ethanol 10% 3 hrs, larvae L3    17 Caffeine 1.5 mg/ml 4 hrs, larvae L3    13 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    136 Caffeine 25 mg/ml 48 hrs, 4-day adult    77 Paraquat 5 mM 48 hrs, 4-day adult    103 Paraquat 10 mM 48 hrs, 4-day adult    68 Rotenone 2 μg 12 hrs, larvae L3    14 Rotenone 8 μg 12 hrs, larvae L3    17 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010, Graveley et al., 2011) mE2_34_mRNA_expression_cluster_17 mE1_20_mRNA_expression_cluster_03
External Data & Images
Linkouts	BDGP expression data • LD06146 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0002783 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG18740-RA FlyExpress - Embryonic expression images (BDGP data) • Show all FlyExpress processed images for mor Stages(s) 1-3 Stages(s) 4-6 Stages(s) 7-8 Stages(s) 9-10 Stages(s) 11-12 Stages(s) 13-16
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal morGD1257 lethal, with Scer\GAL4Act5C.PU morGD1257 lethal, with Scer\GAL4GMR.PF, Scer\GAL4ey.PH morGD1257 lethal, with Scer\GAL4pnr-MD237 morGD1257 lethal | embryonic stage | recessive mor35S1 lethal | pupal stage, with Scer\GAL4pnr-MD237 morGD1257 lethal | recessive mor1 mor2 mor3 mor4 mor5 mor6 mor880 mor3090 Other Phenotypes Allele enhancer of variegation | dominant, with P{hsp26-pt-T}39C-5 mor1 enhancer of variegation | dominant, with P{hsp26-pt-T}39C-27 mor1 enhancer of variegation | dominant, with P{hsp26-pt-T}39C-31 mor1 neuroanatomy defective mordsRNA.cIa neuroanatomy defective | larval stage morGD1257 non-enhancer of variegation, with P{wA}4-4 mor1 non-suppressor of variegation, with P{wA}4-4 mor1 visible | dominant mor3 mor4 mor5 mor6 visible | heat sensitive, with Scer\GAL4salm-459.2 morGD1257 visible | somatic clone mor1 mor2 mor4 morunspecified wild-type mor+t11.8 Phenotype manifest in Allele adult head | dorsal | somatic clone morunspecified arista | somatic clone morunspecified cell | somatic clone mor1 chorion | germline clone mor1 mor2 dorsal appendage | germline clone mor1 mor2 egg | germline clone mor1 mor2 embryonic/larval neuroblast | larval stage morGD1257 embryonic head morunspecified eye, with Scer\GAL4GMR.PF, Scer\GAL4ey.PH morGD1257 eye | somatic clone morunspecified femur | somatic clone mor1 mor2 mor4 ganglion mother cell | larval stage morGD1257 genitalia | somatic clone mor4 haltere | proximal | somatic clone mor2 haltere | somatic clone mor1 mor2 mor4 lateral process | embryonic stage mor4A3 macrochaeta mor4 macrochaeta & haltere | posterior | somatic clone mor1 mesothoracic leg | somatic clone mor1 mor2 mor4 mesothoracic tarsal segment | somatic clone mor1 mor2 mor4 metathoracic laterotergite | somatic clone mor2 mor4 metathoracic leg | somatic clone mor1 mor2 mor4 midgut constriction 1 morunspecified midgut constriction 2 morunspecified ocellus | somatic clone morunspecified pharyngeal bars | embryonic stage mor4A3 presumptive embryonic/larval peripheral nervous system mordsRNA.cIa prothoracic leg | anterior | somatic clone mor1 mor2 mor4 prothoracic leg | somatic clone mor1 mor2 mor4 scutum | ectopic | somatic clone mor2 mor4 sex comb | somatic clone mor1 mor2 mor4 tarsal segment | somatic clone mor1 mor2 mor4 tibia | somatic clone mor1 mor2 mor4 ventral nerve cord commissure mordsRNA.cIa wing, with Scer\GAL4Bx-MS1096 morGD1257 wing | posterior | somatic clone mor1 mor2 mor4 wing hair | ectopic | heat sensitive, with Scer\GAL4salm-459.2 morGD1257 wing margin & macrochaeta | somatic clone mor1 mor2 mor4 wing margin | heat sensitive, with Scer\GAL4salm-459.2 morGD1257 wing sensillum | ectopic | heat sensitive, with Scer\GAL4salm-459.2 morGD1257 wing vein | ectopic mor3 mor5 mor6 wing vein | heat sensitive, with Scer\GAL4salm-459.2 morGD1257
Classical Alleles ( 19 )
For All Classical Alleles Show
Allele of mor Class Mutagen Stocks Known lesion mor1 hypomorphic allele - genetic evidence ethyl methanesulfonate 2 -- mor10 P-element activity 0 Yes mor1736 ethyl methanesulfonate 0 -- mor2403 ethyl methanesulfonate 0 -- mor2 hypomorphic allele - genetic evidence ethyl methanesulfonate 0 -- mor3090 ethyl methanesulfonate 0 -- mor35S1 X ray ethyl methanesulfonate 0 -- mor3 ethyl methanesulfonate 0 -- mor4 ethyl methanesulfonate 0 -- mor4A3 ethyl methanesulfonate 0 -- mor5 gamma ray 0 -- mor6 loss of function allele gamma ray 0 Yes mor880 ethyl methanesulfonate 0 -- mor9 P-element activity 0 Yes mord00861 0 -- morGS-A897 Delta2-3 0 -- morksh-10 ethyl methanesulfonate 0 -- morksh-9 ethyl methanesulfonate 0 -- morunspecified 0 --
Alleles Carried on Transgenic Constructs ( 9 )
For All Alleles Carried on Transgenic Constructs Show
Allele of mor Class Mutagen Stocks Known lesion morGD1257 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes morGL00477 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes morGLV21027 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes morHMS01267 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes morLZ.Scer\UAS in vitro construct - regulatory fusion 1 Yes mor+t11.8 in vitro construct - genomic fragment 0 Yes mordsRNA.cIa in vitro construct - RNAi 0 Yes morKK102003 in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes morScer\UAS.cYa in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(3R)16C3 (Stevaux, 2002.3.12) Df(3R)Exel7327 (Ryder, 2004.4.26) Df(3R)mor-7 (Crosby et al., 1999) Df(3R)mor9 (Crosby et al., 1999) Df(3R)mor10 (Crosby et al., 1999) Df(3R)R24 (Matsubayashi and Yamamoto, 1998) Df(3R)R44 (Matsubayashi and Yamamoto, 1998) Df(3R)sbd105 (Brumby et al., 2004, Nelson and Szauter, 1992, Harding et al., 1995)
Not disrupted in	Df(3R)160R5 (Matsubayashi and Yamamoto, 1998) Df(3R)160R8 (Matsubayashi and Yamamoto, 1998) Df(3R)160R32 (Matsubayashi and Yamamoto, 1998) Df(3R)160R34 (Matsubayashi and Yamamoto, 1998) Df(3R)160R104 (Matsubayashi and Yamamoto, 1998) Df(3R)167R11 (Matsubayashi and Yamamoto, 1998) Df(3R)167R17 (Matsubayashi and Yamamoto, 1998) Df(3R)167R37 (Matsubayashi and Yamamoto, 1998) Df(3R)c(3)G-2 (Matsubayashi and Yamamoto, 1998, Nelson and Szauter, 1992) Df(3R)ea (Brumby et al., 2004) Df(3R)Po2 (Matsubayashi and Yamamoto, 1998, Nelson and Szauter, 1992) Df(3R)Po3 (Nelson and Szauter, 1992) Df(3R)Po4 (Brumby et al., 2004, Nelson and Szauter, 1992) Df(3R)sbd26 (Nelson and Szauter, 1992) Df(3R)sbd45 (Nelson and Szauter, 1992)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD1257} NA P{KK102003} NA P{TRiP.GL00477} NA P{TRiP.GLV21027} NA P{TRiP.HMS01267} NA P{UAS-moira.Y} NA P{UAS-mor.LZ} NA characterization construct P{mor+11.8} NA
Insertions
	Type of insertions Name Expression data insertion of mobile activating element P{EP}Hel89BEP3086 NA P{GSV1}EP-767.1EP-767.1 NA P{GSV1}morGS-A897 NA P{XP}Hel89Bd00861 NA
Gene Ontology: Function, Process & Cellular Component ( 16 unique terms )
Terms Based on Experimental Evidence ( 10 terms )
Molecular Function
CV term Evidence References
protein binding inferred from physical interaction with Bap60 AND inferred from physical interaction with brm AND inferred from physical interaction with dalao AND inferred from physical interaction with z (Kal et al., 2000)
Biological Process
CV term Evidence References
imaginal disc-derived leg morphogenesis inferred from genetic interaction with e(y)3 (Chalkley et al., 2008) imaginal disc-derived wing margin morphogenesis inferred from mutant phenotype (Terriente-Félix and de Celis, 2009) imaginal disc-derived wing vein morphogenesis inferred from mutant phenotype (Terriente-Félix and de Celis, 2009) imaginal disc-derived wing vein specification inferred from mutant phenotype (Curtis et al., 2011) negative regulation of S phase of mitotic cell cycle inferred from genetic interaction with CycE (Brumby et al., 2002) neurogenesis inferred from mutant phenotype (Neumüller et al., 2011) positive regulation of transcription, DNA-dependent inferred from direct assay (Kal et al., 2000)
Cellular Component
CV term Evidence References
brahma complex inferred from direct assay (Kal et al., 2000) nucleus inferred from direct assay (Mohrmann et al., 2004)
Terms Based on Predictions or Assertions ( 8 terms )
Molecular Function
CV term Evidence References
chromatin binding inferred from electronic annotation with InterPro:IPR001005 (FlyBase Curators et al., 2004-) DNA binding inferred from electronic annotation with InterPro:IPR001005, InterPro:IPR012287 (FlyBase Curators et al., 2004-) contributes_to transcription coactivator activity inferred by curator from GO:0035060 (Kal et al., 2000)
Biological Process
CV term Evidence References
ATP-dependent chromatin remodeling inferred from sequence or structural similarity with MGD:Smarcc1; MGI:1203524 (Crosby et al., 1999) chromatin remodeling non-traceable author statement (Crosby, 1997.11.10, Papoulas, 1998.6.9) oogenesis non-traceable author statement (Brizuela and Kennison, 1995) positive regulation of transcription, DNA-dependent inferred from sequence or structural similarity with MGD:Smarcc1; MGI:1203524 (Crosby et al., 1999)
Cellular Component
CV term Evidence References
brahma complex non-traceable author statement (Papoulas, 1998.6.9) traceable author statement (Fry and Peterson, 2001)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
protein-protein
Interacting group Assay References
mor - AttB anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) mor - Bap55 experimental knowledge based (Guruharsha et al., 2011) mor - Bap60 anti tag coimmunoprecipitation, peptide massfingerprinting, experimental knowledge based (Mintseris et al., 2009.11.23, Guruharsha et al., 2011) mor - CG10077 experimental knowledge based (Guruharsha et al., 2011) mor - CG10960 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) mor - CG11505 experimental knowledge based (Guruharsha et al., 2011) mor - CG11594 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) mor - CG12299 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) mor - CG12493 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) mor - CG12576 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) mor - CG12991 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) mor - CG13539 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) mor - CG1421 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) mor - CG14480 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) mor - CG14615 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) mor - CG14995 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) mor - CG15625 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) mor - CG17002 experimental knowledge based (Guruharsha et al., 2011) mor - CG17562 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) mor - CG17776 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) mor - CG17806 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) mor - CG18619 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) mor - CG2017 experimental knowledge based (Guruharsha et al., 2011) mor - CG30491 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) mor - CG30496 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) mor - CG32425 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) mor - CG32479 experimental knowledge based (Guruharsha et al., 2011) mor - CG34159 experimental knowledge based (Guruharsha et al., 2011) mor - CG3706 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) mor - CG4098 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) mor - CG4164 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) mor - CG4210 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) mor - CG43444 experimental knowledge based (Guruharsha et al., 2011) mor - CG4847 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) mor - CG5623 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) mor - CG5746 experimental knowledge based (Guruharsha et al., 2011) mor - CG6272 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) mor - CG7185 experimental knowledge based (Guruharsha et al., 2011) mor - CG7542 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) mor - CG7829 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) mor - CG7888 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) mor - CG8735 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) mor - CG9602 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) mor - CR18854 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) mor - Cdk8 experimental knowledge based (Guruharsha et al., 2011) mor - Clect27 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) mor - Cpr31A anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) mor - Cyp4c3 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) mor - Cyt-c-d anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) mor - Der-2 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) mor - Dhpr anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) mor - E(spl)m3-HLH anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) mor - E(spl)m7-HLH anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) mor - Fas3 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) mor - Gen anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) mor - GstO1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) mor - MED10 experimental knowledge based (Guruharsha et al., 2011) mor - MED11 experimental knowledge based (Guruharsha et al., 2011) mor - MED14 experimental knowledge based (Guruharsha et al., 2011) mor - MED15 experimental knowledge based (Guruharsha et al., 2011) mor - MED16 experimental knowledge based (Guruharsha et al., 2011) mor - MED17 experimental knowledge based (Guruharsha et al., 2011) mor - MED18 experimental knowledge based (Guruharsha et al., 2011) mor - MED20 experimental knowledge based (Guruharsha et al., 2011) mor - MED23 experimental knowledge based (Guruharsha et al., 2011) mor - MED27 experimental knowledge based (Guruharsha et al., 2011) mor - MED30 experimental knowledge based (Guruharsha et al., 2011) mor - MED4 experimental knowledge based (Guruharsha et al., 2011) mor - MED6 experimental knowledge based (Guruharsha et al., 2011) mor - MED7 experimental knowledge based (Guruharsha et al., 2011) mor - MED8 experimental knowledge based (Guruharsha et al., 2011) mor - ND42 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) mor - ND75 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) mor - Nup107 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) mor - Pmm45A anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) mor - Psi experimental knowledge based (Guruharsha et al., 2011) mor - Pu anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) mor - Ran anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) mor - Rnp4F anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) mor - Rpn9 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) mor - Rrp45 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) mor - SNF4Aγ anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) mor - Seipin anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) mor - Snr1 anti tag coimmunoprecipitation, peptide massfingerprinting, experimental knowledge based (Mintseris et al., 2009.11.23, Guruharsha et al., 2011) mor - Spt5 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) mor - Ssadh anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) mor - Stat92E anti bait coimmunoprecipitation, western blot (Panov et al., 2012) mor - Tpc2 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) mor - Tsp42Ed anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) mor - Vinc anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) mor - Wsck anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) mor - ZAP3 experimental knowledge based (Guruharsha et al., 2011) mor - ana2 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) mor - boca experimental knowledge based (Guruharsha et al., 2011) mor - brm experimental knowledge based (Guruharsha et al., 2011) mor - cv anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) mor - dalao experimental knowledge based, anti tag coimmunoprecipitation, peptide massfingerprinting (Guruharsha et al., 2011, Mintseris et al., 2009.11.23) mor - dsh experimental knowledge based (Guruharsha et al., 2011) mor - ebi experimental knowledge based (Guruharsha et al., 2011) mor - enc experimental knowledge based (Guruharsha et al., 2011) mor - fan anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) mor - fh anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) mor - hep anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) mor - hrg anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) mor - ix experimental knowledge based (Guruharsha et al., 2011) mor - mRpL47 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) mor - osa experimental knowledge based (Guruharsha et al., 2011) mor - ptip experimental knowledge based (Guruharsha et al., 2011) mor - snama experimental knowledge based (Guruharsha et al., 2011) mor - ssp anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) mor - ttm50 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) mor - twin anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23)
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions mor allele Gene References mor1 Antp (Brizuela and Kennison, 1997) brm (Vazquez et al., 1999) corto (Lopez et al., 2001) CycE (Brumby et al., 2002) Dp (Staehling-Hampton et al., 1999) lolal (Mishra et al., 2003) net (Marenda et al., 2004) osa (Collins et al., 1999) Pc (Kennison and Tamkun, 1988, Brizuela and Kennison, 1997) Pcl (Brizuela and Kennison, 1997) sgg (Collins and Treisman, 2000) tna (Gutierrez et al., 2003) w (Netter et al., 1998, Cavalli, 1999, Bloyer et al., 2003) mor2 Antp (Brizuela and Kennison, 1997) arm (Barker et al., 2001) brm (Vazquez et al., 1999) Dp (Staehling-Hampton et al., 1999) Pc (Kennison and Tamkun, 1988, Brizuela and Kennison, 1997) Pcl (Brizuela and Kennison, 1997) shg (Barker et al., 2001) tna (Gutierrez et al., 2003) mor3 Pc (Kennison and Tamkun, 1988) mor4 Pc (Kennison and Tamkun, 1988, Brizuela and Kennison, 1997) mor4A3 Dfd (Harding et al., 1995) mor5 Dp (Staehling-Hampton et al., 1999) mor35S1 CycE (Brumby et al., 2002, Brumby et al., 2004) morksh-9 Dp (Staehling-Hampton et al., 1999) morksh-10 Dp (Staehling-Hampton et al., 1999) morunspecified CycE (Brumby et al., 2004) Dfd (Gellon et al., 1997) unspecified Antp (Kennison and Tamkun, 1988) ara (Netter et al., 1998) brm (Armstrong et al., 2005) Chi (Heitzler et al., 2003) ct (Krupp et al., 2005) dm (Secombe et al., 2007) E2f (Staehling-Hampton et al., 1999) Fab-7 (Cavalli, 1999) Pc (Kennison and Tamkun, 1988) ph-p (Fauvarque et al., 1995) ph-PRE (Bloyer et al., 2003) Scr (Gindhart and Kaufman, 1995)
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 66996 DroID - A comprehensive database of gene and protein interactions. • FBgn0002783 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 41942
Orthologs
OrthoDB Orthologs (44) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG61C7FT Dipteran inclusive ortholog search EOG62NJ7N Insect inclusive ortholog search EOG6Z61HM Arthropod inclusive ortholog search EOG6WH71R Metazoa inclusive ortholog search EOG6N67PV
Orthologs in Drosophila Species (EOG61C7FT)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\mor     Drosophila simulans   Dsim\GD20313 Y   Drosophila sechellia   Dsec\GM25739 Y   Drosophila erecta   Dere\GG20223 Y   Drosophila yakuba   Dyak\GE26342 Y   Drosophila ananassae   Dana\GF16465 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA15060 Y   Drosophila persimilis   Dper\GL21720 Y   Drosophila willistoni   Dwil\GK10920 Y   Drosophila virilis   Dvir\GJ23456 Y   Drosophila mojavensis   Dmoj\GI24634 Y   Drosophila grimshawi   Dgri\GH13267 Y
Orthologs in non-Drosophila Dipterans (EOG62NJ7N)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL004358   Anopheles gambiae Malaria mosquito  Agam\AGAP003118   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ016185
Orthologs in non-Dipteran Insects (EOG6Z61HM)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\LOC409501   Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG007754   Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH15168   Atta cephalotes Leafcutter ant  Acep\ACEP26751   Camponotus floridanus Florida carpenter ant  Cflo\CFLO17768   Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL14109   Linepithema humile Argentine ant  Lhum\LH18154   Pogonomyrmex barbatus Red harvester ant  Pbar\PB11991   Solenopsis invicta Red fire ant  Sinv\SINV22140   Solenopsis invicta Red fire ant  Sinv\SINV19370   Acyrthosiphon pisum Pea aphid  Apim\ACYPI068525   Acyrthosiphon pisum Pea aphid  Apim\ACYPI007981   Pediculus humanus Human body louse  Phum\PHUM516080   Tribolium castaneum Red flour beetle  Tcas\TC012356
Orthologs in non-Insect Arthropods (EOG6WH71R)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\ANGPT4   Ixodes scapularis Deer tick  Isca\ISCW014432
Orthologs in non-Arthropod Metazoa (EOG6N67PV)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Caenorhabditis elegans Nematode  Cele\swsn-1   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_023248gn   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_000801gn   Danio rerio Zebrafish  Drer\ENSDARG00000077946   Danio rerio Zebrafish  Drer\smarcc1b   Danio rerio Zebrafish  Drer\smarcc1a   Xenopus tropicalis Western clawed frog  Xtro\smarcc2   Xenopus tropicalis Western clawed frog  Xtro\smarcc1   Gallus gallus Domestic chicken  Ggal\SMARCC1   Mus musculus House mouse  Mmus\Smarcc1   Mus musculus House mouse  Mmus\Smarcc2   Rattus norvegicus Norway rat  Rnor\Smarcc2   Homo sapiens Human  Hsap\SMARCC2
Human Orthologs (1)
Gene OMIM HGNC Hsap\SMARCC2
AAA Orthologs (11) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD20313 Drosophila sechellia Dsec\GM25739 Drosophila erecta Dere\GG20223 Drosophila yakuba Dyak\GE26342 Drosophila ananassae Dana\GF16465 Drosophila pseudoobscura pseudoobscura Dpse\GA15060 Drosophila persimilis Dper\GL21720 Drosophila willistoni Dwil\GK10920 Drosophila virilis Dvir\GJ23456 Drosophila mojavensis Dmoj\GI24634 Drosophila grimshawi Dgri\GH13267
Stocks & Reagents
Stocks Listed in FlyBase ( 7 )
Bloomington	3615 mor1/TM6B, Tb1 8639 y1 w67c23; P{UAS-mor.LZ}2 34919 y1 sc* v1; P{TRiP.HMS01267}attP2 35630 y1 sc* v1; P{TRiP.GL00477}attP40 35662 y1 sc* v1; P{TRiP.GLV21027}attP2
Kyoto	107129 mor1/TM6B, Tb1
VDRC	v6969 w1118; P{GD1257}v6969
Genomic Clones ( 2 )
	BACR04C07 BACR05C20 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 115 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	LD06146 LD22973
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	GH22355 GM05055 GM19966 GM30578 LD02734 LD02818 LD03296 LD03496 LD03743 LD06086 LD08883 LD08884 LD09284 LD09990 LD10801 LD11140 LD12602 LD13491 LD15755 LD16756 LD17388 LD20821 LD23209 LD23215 LD23606 LD23832 LD23833 LD23994 LD24006 LD24202 LD25221 LD25286 LD27419 LD27922 LD28543 LD29895 LD31959 LD36079 LD37835 LD39095 LD39174 LD42655 LD45123 LD45833 LD47102 LP04414 LP05045 LP08044 LP16641 LP18396 RE10257 RE20459 RE27546 RE30210 RE42770 RE47556 RE48039 RE58265 RE61408 RE62212 RE63095 SD05122 SD08360 SD09264 SD09414 SD09441 SD09540 SD13325 SD14563 SD15454 SD20609 SD21322 SD27333
Other clones	741 16257 36915 40613 55635 74486 78674 78959 79840 80849 99648 148326 161638 192599 CK01.8A.B4 CK01.31D.C3 CK01.54C.F10 CK01.101B.H11 CK01.117A.A4 EK027410 EK044353 EK121947 EK127820 EK153658 EK184015 EK204412 EK206260 EK208143 EK212248 EK221942 EK233701 EK254230 EK256606 EK268057 EN08404 IP03686 IP13875 RE01455 RE01657 RE46850
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0002783 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 41942
Antibody Information
	polyclonal (Crosby et al., 1999)
Other Information
Discoverer
	Kennison, 1983.
Etymology
	"Moira" means "fate" in Greek. (Kennison, 1995)
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of	Source for merge of: mor BAP155 (Crosby et al., 1999) Source for merge of: mor CG4275 (FlyBase, 1996-)
Additional comments	Source for merge of mor CG4275 was sequence comparison (date:001104). (FlyBase, 1996-)
Other Comments
	Shows particularly robust cycling of transcription in adult heads, as assessed by expression analysis using high density oligonucleotide arrays with probe generated during three 12-point time course experiments over the course of 6 days. (Claridge-Chang et al., 2001) Pc, Scm, Psc, ph-p and ph-d contribute to the PRC1 (Polycomb repressive complex 1). PRC1 directly antagonizes ATP-dependent remodeling of nucleosomal arrays in a purified system and may directly modulate (and be modified by) SWI/SNF (brm/mor) activity. (Shao et al., 1999) mor is required for the function of multiple homeotic genes in most imaginal tissues. (Brizuela and Kennison, 1997) Identified in a screen for modifiers of the Dfd13/Dfd3 mutant phenotype. Shows no interaction with the Pc mutant phenotype. (Gellon et al., 1997) mor is an essential gene necessary for the transcriptional regulation of multiple homeotic and segmentation genes. Germline clonal analysis demonstrates that mor is important for proper oogenesis and somatic clonal analysis demonstrates that mor is required for the correct differentiation of imaginal structures in the adult cuticle. (Brizuela and Kennison, 1995) mor is required for the function of other homeotic genes. (Gellon et al., 1995) Sections of the Scr regulatory region may be important for regulation of Scr by Polycomb- and trithorax-group genes. (Gindhart and Kaufman, 1995) Mutations of mor interact with Dfd to reduce the viability of the Dfd3/Dfd13 combination. (Harding et al., 1995) Mutations cannot rescue the lethality of the Df(1)ph-2-Psc1 interaction, demonstrating that trx group mutations cannot suppress Pc group phenotypes. (Cheng et al., 1994) Isolated as a dominant suppressor of the antenna-to-leg transformation in a Pc2 AntpNs double heterozygote. Strongly suppresses the antennal transformation in an AntpNs heterozygote, but does not suppress the antennal transformation in a strain containing a heat-shock driven Antp cDNA. Also behaves as a dominant suppressor of Pc and Pcl mutations. All alleles associated with a common recessive embryonic lethality. Mitotic clones induced during larval growth lead to transformation of haltere tissue to wing tissue. Ubx130/mor has low frequency of haltere to wing transformation. (Lindsley and Zimm, 1992) mor is one of the 18 loci identified in a screen for dominant modifiers of Pc and/or Antp phenotypes. Alleles of Pc, Pcl, Scm, Dll, brm, kto, Scr and trx show clear dominant enhancement or suppression of AntpScx, whereas alleles of vtd, Vha55, Su(Pc)37D, urd, mor, skd and osa do not. Mosaic analysis with mutant alleles reveals homeotic transformations in adult cuticle. (Kennison and Tamkun, 1988)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_079649 NM_001202301 RefSeq (Proteins) • NP_524373 NP_001189230 DDBJ / EMBL / GenBank • AA247002 AA438344 AA441011 AAC28454 AAD12718 AAD17318 AAF55259 AAM49864 ADV37321 AF033823 AF071502 AF124375 AW941613 AY118495 BI362319 Entrez Gene - A searchable database of RefSeq genes. • 41942 UniProtKB/TrEMBL • Q7KND4 Q7KPY3 Q8MSY3 Q9VF03
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • SANT/Myb domain (IPR001005) SWIRM domain (IPR007526) Homeodomain-like (IPR009057) BRCT domain (IPR001357) SANT domain (IPR017884) Winged helix-turn-helix DNA-binding domain (IPR011991) BDGP expression data - Patterns of gene expression in Drosophila embryogenesis • LD06146
Linkouts
	BioGRID - A database of protein and genetic interactions • 66996 DroID - A comprehensive database of gene and protein interactions. • FBgn0002783 DRSC - Results from RNAi screens. • FBgn0002783 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0002783 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG18740-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0002783 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 41942 Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution • /polycomb/moira1.htm InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 41942 modMine - Data generated by the modENCODE project. • FBgn0002783
Synonyms & Secondary IDs ( 17 )
Reported As
Symbol Synonym	BAP155 (Aalfs and Kingston, 2000, Sudarsanam and Winston, 2000, Papoulas, 1998.6.9, Kingston and Narlikar, 1999, Wade and Wolffe, 1999, Papoulas et al., 1998, ) CG4275   CG18740 (Klebes et al., 2005, Whitfield, 2000.10.31, Molnar et al., 2006, Casola et al., 2007, Keleman et al., 2009.8.5, Ni et al., 2011.7.19) dmMOIRA (Mohrmann et al., 2002) E(E2F)3B (Staehling-Hampton et al., 1999) l(3)89B1   Moira (Klochendler-Yeivin et al., 2002, Stevaux, 2000.3.3) moira (Tokusumi et al., 2012) mor (Curtis et al., 2011, Gan et al., 2010, Marenda et al., 2003, Arancio et al., 2010, Hirose et al., 2001, Baeg et al., 2007, Molnar et al., 2006, Dietzl et al., 2007, Xing et al., 2007, Chalkley et al., 2008, Schmidt et al., 2008, Smulders-Srinivasan et al., 2010, Vázquez et al., 2008, Slack et al., 2007, Petruk et al., 2008, Hauenschild et al., 2008, Terriente-Félix and de Celis, 2009, Sing et al., 2009, Moeller et al., 2005, Di Stefano et al., 2011, Neumüller et al., 2011, Nakamura et al., 2008, Davis et al., 2011, Rodriguez-Jato et al., 2011, Antao et al., 2012) MOR (Schwartz and Pirrotta, 2007, Taylor-Harding et al., 2004, Moshkin et al., 2007, Vorobyeva et al., 2009, Lagarou et al., 2008, Moshkin et al., 2009, Reddy et al., 2010, Vorobyeva et al., 2009, Soshnikova et al., 2008, Vorobyeva et al., 2008) Mor (Secombe et al., 2007, Kallappagoudar et al., 2010, Waldholm et al., 2011, Diop et al., 2008, Nakayama et al., 2012) MOR/BAP155 (Mohrmann et al., 2004) Swi3D (Crosby et al., 1999)
Name Synonym	Bap155/Moira (Dekanty et al., 2010) brahma-associated protein 155 (Papoulas et al., 1998, ) brahma associated protein 155 kDa (Papoulas, 1998.6.9) brahma-like   moira (Zak, 1999.1.28, Zak and Crosby, 1997.1.12, Gellon et al., 1997, Secombe et al., 2007, Hirose et al., 2001, Moeller et al., 2005, Xing et al., 2007, Tadros et al., 2007, Schneiderman et al., 2009, Sing et al., 2009, Yagi and Ip, 2005, Mourikis et al., 2010, Nowak et al., 2012, Nakamura et al., 2008, Davis et al., 2011) Moira (Schuettengruber et al., 2007, Ullah et al., 2007, Vorobyeva et al., 2009, Lagarou et al., 2008, Waldholm et al., 2011, Soshnikova et al., 2008, Antao et al., 2012)
Secondary FlyBase IDs
	FBgn0025464 FBgn0042208
References ( 165 )
Generate a list of	All references relating to this gene ( 165 )
List References by type	Research paper  ( 103 ) Supplementary material  ( 5 ) Review  ( 19 ) Erratum  ( 2 ) Personal communication to FlyBase  ( 13 ) Abstract  ( 15 ) FlyBase analysis  ( 2 ) DNA/RNA sequence record  ( 3 ) Book  ( 1 ) Website  ( 1 ) Curated genome annotation  ( 1 )
Recent research papers ( 12 )
	Antao et al., 2012, Mol. Cell. Biol. 32(12): 2170--2182 Protein Landscape at Drosophila melanogaster Telomere-Associated Sequence Repeats. [FBrf0218429] Krauchunas et al., 2012, Dev. Biol. 370(1): 125--134 Protein phosphorylation changes reveal new candidates in the regulation of egg activation and early embryogenesis in D. melanogaster. [FBrf0219342] Nakayama et al., 2012, Development 139(24): 4582--4590 The PBAP remodeling complex is required for histone H3.3 replacement at chromatin boundaries and for boundary functions. [FBrf0219981] Nowak et al., 2012, PLoS Genet. 8(3): e1002547 Akirin Links Twist-Regulated Transcription with the Brahma Chromatin Remodeling Complex during Embryogenesis. [FBrf0217616] Panov et al., 2012, Nucleic Acids Res. 40(6): 2445--2453 Transcription co-activator SAYP mediates the action of STAT activator. [FBrf0218425] Tokusumi et al., 2012, PLoS ONE 7(7): e41604 Gene regulatory networks controlling hematopoietic progenitor niche cell production and differentiation in the Drosophila lymph gland. [FBrf0219204] Curtis et al., 2011, Dev. Biol. 350(2): 534--547 Histone lysine demethylases function as co-repressors of SWI/SNF remodeling activities during Drosophila wing development. [FBrf0212876] Davis et al., 2011, BMC Dev. Biol. 11: 66 Identification of common and cell type specific LXXLL motif EcR cofactors using a bioinformatics refined candidate RNAi screen in Drosophila melanogaster cell lines. [FBrf0216830] Di Stefano et al., 2011, Genes Dev. 25(1): 17--28 Functional antagonism between histone H3K4 demethylases in vivo. [FBrf0212709] Neumüller et al., 2011, Cell Stem Cell 8(5): 580--593 Genome-Wide Analysis of Self-Renewal in Drosophila Neural Stem Cells by Transgenic RNAi. [FBrf0213621] Rodriguez-Jato et al., 2011, PLoS ONE 6(12): e27479 Drosophila melanogaster dHCF Interacts with both PcG and TrxG Epigenetic Regulators. [FBrf0216958] Waldholm et al., 2011, BMC Mol. Biol. 12: 46 SWI/SNF regulates the alternative processing of a specific subset of pre-mRNAs in Drosophila melanogaster. [FBrf0216757] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2011 Show reviews ...