• Home
• Tools
  • Tools Overview
  • Query Tools

    
    • QuickSearch
    • QueryBuilder
    • TermLink
    • CytoSearch
    • Interactions Browser
    • ImageBrowse
    • Find A Person
    • Google™ FlyBase
  • Genomic/Map Tools

    
    • BLAST
    • GBrowse
    • CytoSearch
    • Aberrations Maps
    • Chromosome Maps
    • Coordinates Converter
  • Retrieve/Convert

    
    • Batch Download
    • Coordinates Converter
    • ID Converter
  • Data Submission

    
    • Fast-Track Your Paper
    • Submit Personal Comm
    • Add A New Person
    • Update Person Info
  • People

    
    • Find A Person
    • Add A New Person
    • Update Person Info
• Files
  • Files Overview
  • Downloads:
  • Precomputed files
  • Archived data
  • Releases (FTP)
  • Genomes (FTP)
  • AAA data (FTP)
  • Lists:
  • Transposons (Dmel)
  • Transposons (other)
  • Vectors & Constructs
  • Anatomical Terms
  • Map Conversion
• Species
  • Phylogeny
  • Sequenced Species
  • Synteny Table
  • Color Illustrations
  • Abbreviations
• Documents
  • About FlyBase
  • Reference Manual:
  • Sections
  • Contents
  • Nomenclature
  • Release Notes
• Resources
  • All Resources
  • Model Organisms
  • Stock Collections
  • Other links:
  • BDGP
  • DGRC
  • FlyExpress
  • Interactive Fly
  • modENCODE
  • Textpresso for Fly
• News
  • News
  • FlyBase Forum
  • FlyBase Positions
  • Meetings
  • Courses
  • Fly Board
  • White papers
  • Funding
  • bionet.dros
• Help
  • Google™ FlyBase
  • Site Map
  • FAQs
  • FlyBase Guides
  • Video Tutorials
  • Report help
  • New to Flies
  • Pers. comm.
  • Author guidelines
  • Contact FlyBase
• Archives
  • Prior Release
  • Other Archives
  • Coordinate Converter

Gene Dmel\mr

General Information
Symbol	Dmel\mr	Species	D. melanogaster
Name	morula	Annotation symbol	CG3060
Feature type	protein_coding_gene	FlyBase ID	FBgn0002791
Gene Model Status	Current	Stock availability	15 publicly available
Also Known As	APC2
Genomic Location
Chromosome (arm)	2R	Recombination map	2-106.7
Cytogenetic map	60A15-60A15	Sequence location	2R:19,859,956..19,862,935 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene morula is referred to in FlyBase by the symbol Dmel\mr (CG3060, FBgn0002791). It is a protein_coding_gene from Drosophila melanogaster. An electronic pipeline based on InterPro domains suggests that it has the molecular function: ubiquitin protein ligase binding. There is experimental evidence that it is involved in the biological process: negative regulation of synaptic growth at neuromuscular junction; regulation of synaptic transmission. 18 alleles are reported. The phenotypes of these alleles are annotated with: organ system; organ system subdivision; female germline cyst; egg; adult segment; eo support cell; endocrine system; external compound sense organ; multicellular structure; sensillum; non-connected functional system; imaginal precursor; peripheral nervous system. It has one annotated transcript and one annotated polypeptide. Protein features are: Anaphase-promoting complex subunit 2, C-terminal; Cullin homology; Cullin, N-terminal; Winged helix-turn-helix transcription repressor DNA-binding. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of low expression. Peak expression observed within 00-12 hour embryonic stages. Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: larval/adult central nervous system, larval trachea, adult ovary, adult testis. Comments on Affy2 ProbeSet: ProbeSet 1635875_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of mr. Gene sequence location is 2R:19859956..19862935.
External Summaries
Phenotypic Description from the Red Book (Lindsley & Zimm 1992)
Gene/Allele symbols may differ from current usage	mr: morula mr: morula Eyes rough. Bristles irregularly reduced in size and number. Abdominal sclerites often smaller. Developmental study by Lees and Waddington [1942, Proc. Roy. Soc. (London), Ser. B 131: 87-100] shows that effect on bristles results from general slowing of bristle growth. Female entirely sterile, has underdeveloped ovaries. At 19, bristles nearly normal and eyes nearly wild type. RK2 at 25 and above. mr2 Less extreme than mr. Nearly wild type at 19. Female entirely sterile. Oogenesis normal through stage 4; then compound nurse cell chromosomes fall apart and degenerate. Karyosome of oocyte also disappears. Oogenesis does not proceed beyond sixth stage (King, 1964, Royal Entomol. Soc. London Symposium 2, Insect Reproduction, pp. 13-25). RK2 at 25 or above.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2012_01	Sequence features BKN20887 HFA04332
FB2011_10	References Herranz et al., 2010, Mol. Ecol. 19(19): 4255--4264
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 60A15-60A15   Limits computationally determined from genome sequence between P{EP}TalEP489&P{EP}CG3065EP316 and P{lacW}Phmk07623&P{lacW}tsrk05633
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location	2-106.7
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\mr for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	DGC clone appears problematic (LD45730): incomplete CDS.
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) mr-RA FBtr0072156  NM_138018   2557   802
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein mr-PA   FBpp0072065   91.6   802   4.84     NP_611862   AAF47123
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Cullin, N-terminal (IPR001373) Anaphase-promoting complex subunit 2, C-terminal (IPR014786) Cullin homology (IPR016158) Winged helix-turn-helix transcription repressor DNA-binding (IPR011991)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA439215   AA441659   AA536457   AA538597   AA541203   AA820997   AA820998   AA950667   AE013599 AAF47123   AI455568   AI513454   AI519998   AI542724   AW943800   AY058717 AAL13946   AY129297 AAM97765   BH854685   BI216898   BI242048   BI367281   BI370646   BI374094   BI580142   BT031326   CL705790   CO178142   CO287296   CO303344   CO316476   CO344707   EC215321   EC237644   EC247420   EC253926   EL871709   EL871838   EL871968   ES689938   ES689939
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q95TK2 Q9W1E5
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0002791    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0002791 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of low expression. Peak expression observed within 00-12 hour embryonic stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0002791 expression level Developmental Stage   Expression Level embryo 00-02hr    2101 embryo 02-04hr    1510 embryo 04-06hr    1102 embryo 06-08hr    1406 embryo 08-10hr    1287 embryo 10-12hr    800 embryo 12-14hr    683 embryo 14-16hr    327 embryo 16-18hr    305 embryo 18-20hr    232 embryo 20-22hr    256 embryo 22-24hr    303 larva L1    282 larva L2    365 larva L3 12hr old    314 larva L3 puffstage 1-2    531 larva L3 puffstage 3-6    709 larva L3 puffstage 7-9    980 white prepupae new    807 white prepupae 12hr    988 white prepupae 24hr    1146 pupae 2d postWPP    857 pupae 3d postWPP    633 pupae 4d postWPP    349 adult male 01day    755 adult male 05day    942 adult male 30day    840 adult female 01day    607 adult female 05day    1375 adult female 30day    1349 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (2101) embryo 02-04hr  (1510) embryo 04-06hr  (1102) embryo 06-08hr  (1406) embryo 08-10hr  (1287) embryo 10-12hr  (800) embryo 12-14hr  (683) embryo 14-16hr  (327) embryo 16-18hr  (305) embryo 18-20hr  (232) embryo 20-22hr  (256) embryo 22-24hr  (303) larva L1  (282) larva L2  (365) larva L3 12hr old  (314) larva L3 puffstage 1-2  (531) larva L3 puffstage 3-6  (709) larva L3 puffstage 7-9  (980) white prepupae new  (807) white prepupae 12hr  (988) white prepupae 24hr  (1146) pupae 2d postWPP  (857) pupae 3d postWPP  (633) pupae 4d postWPP  (349) adult male 01day  (755) adult male 05day  (942) adult male 30day  (840) adult female 01day  (607) adult female 05day  (1375) adult female 30day  (1349) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (2101) embryo 02-04hr  (1510) embryo 04-06hr    1102 embryo 06-08hr  1406 embryo 08-10hr    1287 embryo 10-12hr    800 embryo 12-14hr    683 embryo 14-16hr    327 embryo 16-18hr    305 embryo 18-20hr    232 embryo 20-22hr    256 embryo 22-24hr    303 larva L1    282 larva L2    365 larva L3 12hr old    314 larva L3 puffstage 1-2    531 larva L3 puffstage 3-6    709 larva L3 puffstage 7-9    980 white prepupae new    807 white prepupae 12hr    988 white prepupae 24hr    1146 pupae 2d postWPP    857 pupae 3d postWPP    633 pupae 4d postWPP    349 adult male 01day    755 adult male 05day    942 adult male 30day    840 adult female 01day    607 adult female 05day    1375 adult female 30day    1349 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    2101 embryo 02-04hr    1510 embryo 04-06hr    1102 embryo 06-08hr    1406 embryo 08-10hr    1287 embryo 10-12hr    800 embryo 12-14hr    683 embryo 14-16hr    327 embryo 16-18hr    305 embryo 18-20hr    232 embryo 20-22hr    256 embryo 22-24hr    303 larva L1    282 larva L2    365 larva L3 12hr old    314 larva L3 puffstage 1-2    531 larva L3 puffstage 3-6    709 larva L3 puffstage 7-9    980 white prepupae new    807 white prepupae 12hr    988 white prepupae 24hr    1146 pupae 2d postWPP    857 pupae 3d postWPP    633 pupae 4d postWPP    349 adult male 01day    755 adult male 05day    942 adult male 30day    840 adult female 01day    607 adult female 05day    1375 adult female 30day    1349 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    2101 embryo 02-04hr    1510 embryo 04-06hr    1102 embryo 06-08hr    1406 embryo 08-10hr    1287 embryo 10-12hr    800 embryo 12-14hr    683 embryo 14-16hr    327 embryo 16-18hr    305 embryo 18-20hr    232 embryo 20-22hr    256 embryo 22-24hr    303 larva L1    282 larva L2    365 larva L3 12hr old    314 larva L3 puffstage 1-2    531 larva L3 puffstage 3-6    709 larva L3 puffstage 7-9    980 white prepupae new    807 white prepupae 12hr    988 white prepupae 24hr    1146 pupae 2d postWPP    857 pupae 3d postWPP    633 pupae 4d postWPP    349 adult male 01day    755 adult male 05day    942 adult male 30day    840 adult female 01day    607 adult female 05day    1375 adult female 30day    1349 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0002791 expression level Developmental Stage   Expression Level embryo 00-02hr    2101 embryo 02-04hr    1510 embryo 04-06hr    1102 embryo 06-08hr    1406 embryo 08-10hr    1287 embryo 10-12hr    800 embryo 12-14hr    683 embryo 14-16hr    327 embryo 16-18hr    305 embryo 18-20hr    232 embryo 20-22hr    256 embryo 22-24hr    303 larva L1    282 larva L2    365 larva L3 12hr old    314 larva L3 puffstage 1-2    531 larva L3 puffstage 3-6    709 larva L3 puffstage 7-9    980 white prepupae new    807 white prepupae 12hr    988 white prepupae 24hr    1146 pupae 2d postWPP    857 pupae 3d postWPP    633 pupae 4d postWPP    349 adult male 01day    755 adult male 05day    942 adult male 30day    840 adult female 01day    607 adult female 05day    1375 adult female 30day    1349 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (2101) embryo 02-04hr  (1510) embryo 04-06hr  (1102) embryo 06-08hr  (1406) embryo 08-10hr  (1287) embryo 10-12hr  (800) embryo 12-14hr  (683) embryo 14-16hr  (327) embryo 16-18hr  (305) embryo 18-20hr  (232) embryo 20-22hr  (256) embryo 22-24hr  (303) larva L1  (282) larva L2  (365) larva L3 12hr old  (314) larva L3 puffstage 1-2  (531) larva L3 puffstage 3-6  (709) larva L3 puffstage 7-9  (980) white prepupae new  (807) white prepupae 12hr  (988) white prepupae 24hr  (1146) pupae 2d postWPP  (857) pupae 3d postWPP  (633) pupae 4d postWPP  (349) adult male 01day  (755) adult male 05day  (942) adult male 30day  (840) adult female 01day  (607) adult female 05day  (1375) adult female 30day  (1349) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  2101 embryo 02-04hr  1510 embryo 04-06hr    1102 embryo 06-08hr  1406 embryo 08-10hr    1287 embryo 10-12hr    800 embryo 12-14hr    683 embryo 14-16hr    327 embryo 16-18hr    305 embryo 18-20hr    232 embryo 20-22hr    256 embryo 22-24hr    303 larva L1    282 larva L2    365 larva L3 12hr old    314 larva L3 puffstage 1-2    531 larva L3 puffstage 3-6    709 larva L3 puffstage 7-9    980 white prepupae new    807 white prepupae 12hr    988 white prepupae 24hr    1146 pupae 2d postWPP    857 pupae 3d postWPP    633 pupae 4d postWPP    349 adult male 01day    755 adult male 05day    942 adult male 30day    840 adult female 01day    607 adult female 05day    1375 adult female 30day    1349 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    2101 embryo 02-04hr    1510 embryo 04-06hr    1102 embryo 06-08hr    1406 embryo 08-10hr    1287 embryo 10-12hr    800 embryo 12-14hr    683 embryo 14-16hr    327 embryo 16-18hr    305 embryo 18-20hr    232 embryo 20-22hr    256 embryo 22-24hr    303 larva L1    282 larva L2    365 larva L3 12hr old    314 larva L3 puffstage 1-2    531 larva L3 puffstage 3-6    709 larva L3 puffstage 7-9    980 white prepupae new    807 white prepupae 12hr    988 white prepupae 24hr    1146 pupae 2d postWPP    857 pupae 3d postWPP    633 pupae 4d postWPP    349 adult male 01day    755 adult male 05day    942 adult male 30day    840 adult female 01day    607 adult female 05day    1375 adult female 30day    1349 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    2101 embryo 02-04hr    1510 embryo 04-06hr    1102 embryo 06-08hr    1406 embryo 08-10hr    1287 embryo 10-12hr    800 embryo 12-14hr    683 embryo 14-16hr    327 embryo 16-18hr    305 embryo 18-20hr    232 embryo 20-22hr    256 embryo 22-24hr    303 larva L1    282 larva L2    365 larva L3 12hr old    314 larva L3 puffstage 1-2    531 larva L3 puffstage 3-6    709 larva L3 puffstage 7-9    980 white prepupae new    807 white prepupae 12hr    988 white prepupae 24hr    1146 pupae 2d postWPP    857 pupae 3d postWPP    633 pupae 4d postWPP    349 adult male 01day    755 adult male 05day    942 adult male 30day    840 adult female 01day    607 adult female 05day    1375 adult female 30day    1349 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0002791    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0002791 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: larval/adult central nervous system, larval trachea, adult ovary, adult testis. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0002791 expression level Tissue   Expression Level Larval Central Nervous System    181.45 Larval Midgut    43.6 Larval Hindgut    62.5 Larval Malpighian Tubules    51.5 Larval Fat Body    62.8 Larval Salivary Gland    59 Larval Trachea    109.875 Larval Carcass    59.925 Adult Head    49 Adult Eye    61.175 Adult Brain    89.3 Adult Thoracic-Abdominal Ganglion    100.5 Adult Crop    66.6 Adult Midgut    43.6 Adult Hindgut    51.3 Adult Malpighian Tubules    57.4 Adult Fat Body    44.3 Adult Salivary Gland no informative data Adult Heart    51.175 Adult VirginFemale Spermatheca    58.2 Adult InseminatedFemale Spermatheca    61.5 Adult Ovary    165.8 Adult Testis    214.3 Adult Male Accessory Gland    82.1 Adult Carcass    41.2 Expression Level Scale  None   Low   Moderate  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    181.45 Larval Midgut    43.6 Larval Hindgut    62.5 Larval Malpighian Tubules    51.5 Larval Fat Body    62.8 Larval Salivary Gland    59 Larval Trachea    109.875 Larval Carcass    59.925 Adult Head    49 Adult Eye    61.175 Adult Brain    89.3 Adult Thoracic-Abdominal Ganglion    100.5 Adult Crop    66.6 Adult Midgut    43.6 Adult Hindgut    51.3 Adult Malpighian Tubules    57.4 Adult Fat Body    44.3 Adult Salivary Gland no informative data Adult Heart    51.175 Adult VirginFemale Spermatheca    58.2 Adult InseminatedFemale Spermatheca    61.5 Adult Ovary    165.8 Adult Testis    214.3 Adult Male Accessory Gland    82.1 Adult Carcass    41.2 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    181.45 Larval Midgut    43.6 Larval Hindgut    62.5 Larval Malpighian Tubules    51.5 Larval Fat Body    62.8 Larval Salivary Gland    59 Larval Trachea    109.875 Larval Carcass    59.925 Adult Head    49 Adult Eye    61.175 Adult Brain    89.3 Adult Thoracic-Abdominal Ganglion    100.5 Adult Crop    66.6 Adult Midgut    43.6 Adult Hindgut    51.3 Adult Malpighian Tubules    57.4 Adult Fat Body    44.3 Adult Salivary Gland no informative data Adult Heart    51.175 Adult VirginFemale Spermatheca    58.2 Adult InseminatedFemale Spermatheca    61.5 Adult Ovary    165.8 Adult Testis    214.3 Adult Male Accessory Gland    82.1 Adult Carcass    41.2 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    181.45 Larval Midgut    43.6 Larval Hindgut    62.5 Larval Malpighian Tubules    51.5 Larval Fat Body    62.8 Larval Salivary Gland    59 Larval Trachea    109.875 Larval Carcass    59.925 Adult Head    49 Adult Eye    61.175 Adult Brain    89.3 Adult Thoracic-Abdominal Ganglion    100.5 Adult Crop    66.6 Adult Midgut    43.6 Adult Hindgut    51.3 Adult Malpighian Tubules    57.4 Adult Fat Body    44.3 Adult Salivary Gland no informative data Adult Heart    51.175 Adult VirginFemale Spermatheca    58.2 Adult InseminatedFemale Spermatheca    61.5 Adult Ovary    165.8 Adult Testis    214.3 Adult Male Accessory Gland    82.1 Adult Carcass    41.2 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0002791 expression level Tissue   Expression Level Larval Central Nervous System    181.45 Larval Midgut    43.6 Larval Hindgut    62.5 Larval Malpighian Tubules    51.5 Larval Fat Body    62.8 Larval Salivary Gland    59 Larval Trachea    109.875 Larval Carcass    59.925 Adult Head    49 Adult Eye    61.175 Adult Brain    89.3 Adult Thoracic-Abdominal Ganglion    100.5 Adult Crop    66.6 Adult Midgut    43.6 Adult Hindgut    51.3 Adult Malpighian Tubules    57.4 Adult Fat Body    44.3 Adult Salivary Gland no informative data Adult Heart    51.175 Adult VirginFemale Spermatheca    58.2 Adult InseminatedFemale Spermatheca    61.5 Adult Ovary    165.8 Adult Testis    214.3 Adult Male Accessory Gland    82.1 Adult Carcass    41.2 Expression Level Scale  None   Low   Moderate  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    181.45 Larval Midgut    43.6 Larval Hindgut    62.5 Larval Malpighian Tubules    51.5 Larval Fat Body    62.8 Larval Salivary Gland    59 Larval Trachea    109.875 Larval Carcass    59.925 Adult Head    49 Adult Eye    61.175 Adult Brain    89.3 Adult Thoracic-Abdominal Ganglion    100.5 Adult Crop    66.6 Adult Midgut    43.6 Adult Hindgut    51.3 Adult Malpighian Tubules    57.4 Adult Fat Body    44.3 Adult Salivary Gland no informative data Adult Heart    51.175 Adult VirginFemale Spermatheca    58.2 Adult InseminatedFemale Spermatheca    61.5 Adult Ovary    165.8 Adult Testis    214.3 Adult Male Accessory Gland    82.1 Adult Carcass    41.2 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    181.45 Larval Midgut    43.6 Larval Hindgut    62.5 Larval Malpighian Tubules    51.5 Larval Fat Body    62.8 Larval Salivary Gland    59 Larval Trachea    109.875 Larval Carcass    59.925 Adult Head    49 Adult Eye    61.175 Adult Brain    89.3 Adult Thoracic-Abdominal Ganglion    100.5 Adult Crop    66.6 Adult Midgut    43.6 Adult Hindgut    51.3 Adult Malpighian Tubules    57.4 Adult Fat Body    44.3 Adult Salivary Gland no informative data Adult Heart    51.175 Adult VirginFemale Spermatheca    58.2 Adult InseminatedFemale Spermatheca    61.5 Adult Ovary    165.8 Adult Testis    214.3 Adult Male Accessory Gland    82.1 Adult Carcass    41.2 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    181.45 Larval Midgut    43.6 Larval Hindgut    62.5 Larval Malpighian Tubules    51.5 Larval Fat Body    62.8 Larval Salivary Gland    59 Larval Trachea    109.875 Larval Carcass    59.925 Adult Head    49 Adult Eye    61.175 Adult Brain    89.3 Adult Thoracic-Abdominal Ganglion    100.5 Adult Crop    66.6 Adult Midgut    43.6 Adult Hindgut    51.3 Adult Malpighian Tubules    57.4 Adult Fat Body    44.3 Adult Salivary Gland no informative data Adult Heart    51.175 Adult VirginFemale Spermatheca    58.2 Adult InseminatedFemale Spermatheca    61.5 Adult Ovary    165.8 Adult Testis    214.3 Adult Male Accessory Gland    82.1 Adult Carcass    41.2 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland no informative data Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    49   NA  Eye    61.175   NA  Brain    89.3   181.45  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    100.5   NA  Crop    66.6   43.6  Midgut    43.6   62.5  Hindgut    51.3   51.5  Malpighian Tubules    57.4   62.8  Fat Body    44.3   59  Salivary Gland    no informative data   NA  Heart    51.175   109.875  Trachea    NA   NA  VirginFemale Spermatheca    58.2   NA  InseminatedFemale Spermatheca    61.5   NA  Ovary    165.8   NA  Testis    214.3   NA  Male Accessory Gland    82.1   59.925  Carcass    41.2 modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_06
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0002791 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG3060-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal (with mr3) mr4 lethal (with mr4) mr3 lethal | partially (with mr1) mr3 lethal | partially (with mr3) mr1 lethal | recessive mr4 mr5 viable mrEY04503 viable, with Scer\GAL4pnr-MD237 mrGD1489 Sterility Allele female sterile | recessive mr1 mr2 fertile mrEY04503 sterile (with mr1) mr2 sterile (with mr2) mr1 Other Phenotypes Allele mitotic cell cycle defective | germline clone | recessive mr5 mitotic cell cycle defective | recessive mr4 mr5 mitotic cell cycle defective | recessive | somatic clone mr5 neuroanatomy defective mr3 neuroanatomy defective, with Scer\GAL4elav-C155 mrdsRNA.Scer\UAS neurophysiology defective mr3 visible, with Scer\GAL4pnr-MD237 mrGD1489 visible | recessive mrunspecified Phenotype manifest in Allele egg mr1 mr2 embryo mr1 mr2 embryonic/larval neuromuscular junction mr3 embryonic/larval neuromuscular junction, with Scer\GAL4elav-C155 mrdsRNA.Scer\UAS embryonic/larval salivary gland | embryonic stage mrunspecified eye mr1 mr2 mrunspecified eye | somatic clone mr5 follicle cell mr2 hindgut imaginal ring mrunspecified macrochaeta | somatic clone mr5 mesothoracic tergum, with Scer\GAL4pnr-MD237 mrGD1489 mitotic cell cycle | embryonic stage mr1 mr2 mitotic cell cycle | germline clone mr5 mitotic cell cycle | larval stage | somatic clone mr5 NMJ bouton | supernumerary mr3 NMJ bouton | supernumerary, with Scer\GAL4elav-C155 mrdsRNA.Scer\UAS nuclear chromosome | maternal effect (with mr1) mr2 nuclear chromosome | maternal effect (with mr2) mr1 nurse cell mr1 nurse cell (with mr1) mr2 nurse cell (with mr2) mr1 nurse cell & nuclear chromosome mr2 mr5 nurse cell & nucleus mr2 nurse cell & spindle mr5 nurse cell ring canal mr2 polar body nucleus mr2 ring gland mrunspecified spindle | embryonic stage mr1 mr2 spindle | germline clone mr5 spindle | maternal effect (with mr1) mr2 spindle | maternal effect (with mr2) mr1 tergite mr1 mr2 trichogen cell, with Scer\GAL4pnr-MD237 mrGD1489
Classical Alleles ( 12 )
For All Classical Alleles Show
Allele of mr Class Mutagen Stocks Known lesion mr1 6 Yes mr2 spontaneous 3 Yes mr5-SZ-3002 1 -- mrEY04503 P-element activity 1 -- mrKG07756 P-element activity 1 -- mr3 ethyl methanesulfonate 0 Yes mr4 ethyl methanesulfonate 0 Yes mr5 ethyl methanesulfonate 0 Yes mrAc2 ethyl methanesulfonate 0 -- mrAk2 ethyl methanesulfonate 0 -- mrAs2 ethyl methanesulfonate 0 -- mrunspecified 0 --
Alleles Carried on Transgenic Constructs ( 6 )
For All Alleles Carried on Transgenic Constructs Show
Allele of mr Class Mutagen Stocks Known lesion mrGD1489 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes mrKK100791 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes mrdsRNA.Scer\UAS in vitro construct - regulatory fusion in vitro construct - RNAi 0 Yes mrnos.T:Hsap\MYC in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes mrScer\UAS.P\T.cKa in vitro construct - regulatory fusion 0 Yes mrScer\UAS.T:Avic\GFP-EGFP in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(2R)BSC136 (Christensen and Cook, 2006.1.19) Df(2R)BSC652 (Christensen et al., 2008.10.20) Df(2R)BSC770 (Christensen et al., 2009.2.28) Df(2R)Exel6080 (Ryder, 2004.4.26) Df(2R)Exel7182 (Ryder, 2004.4.26) Df(2R)or-BR6 (Reed, 1992) Df(2R)or-BR11 (Reed, 1992) In(2LR)ltG10LBR27R (Reed and Orr-Weaver, 1997) In(2LR)ltG10LX-4-27R (Reed, 1992)
Not disrupted in	Df(2R)106 (Reed, 1992) Df(2R)bw-DRa (Reed, 1992) Df(2R)bw-DRj (Reed, 1992) Df(2R)bw-DRp (Reed, 1992) Df(2R)bw-DRs (Reed, 1992) Df(2R)bw-DRt (Reed, 1992) Df(2R)bw-S46 (Reed, 1992) Df(2R)Px1 (Bridges, 1937) In(2LR)ltG10LCD-20R (Reed, 1992) In(2LR)ltG10LSDS9-1R (Reed, 1992) In(2LR)Px4 (Reed, 1992)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct M{UAS-mr.EGFP} NA P{GD1489} NA P{KK100791} NA P{UAS-mr.RNAi} NA P{UASp-mr.K} NA characterization construct P{nos-mr.myc} NA
Insertions
	Type of insertions Name Expression data insertion of mobile activating element P{EPgy2}mrEY04503 NA miscellaneous insertions P{RS5}mr5-SZ-3002 NA P{SUPor-P}mrKG07756 NA insertion of enhancer trap P{lacW}l(2)SH1722SH1722 No
Gene Ontology: Function, Process & Cellular Component ( 8 unique terms )
Terms Based on Experimental Evidence ( 2 terms )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
negative regulation of synaptic growth at neuromuscular junction inferred from mutant phenotype (van Roessel et al., 2004) regulation of synaptic transmission inferred from mutant phenotype (van Roessel et al., 2004)
Cellular Component ( 0 terms)
Terms Based on Predictions or Assertions ( 6 terms )
Molecular Function
CV term Evidence References
ubiquitin protein ligase binding inferred from electronic annotation with InterPro:IPR001373, InterPro:IPR016158 (FlyBase Curators et al., 2004-)
Biological Process
CV term Evidence References
mitotic anaphase non-traceable author statement (Wallace, 2002.7.5) regulation of cell cycle traceable author statement (Lee and Orr-Weaver, 2003) ubiquitin-dependent protein catabolic process inferred from electronic annotation with InterPro:IPR001373, InterPro:IPR016158 (FlyBase Curators et al., 2004-)
Cellular Component
CV term Evidence References
anaphase-promoting complex non-traceable author statement (Wallace, 2002.7.5) traceable author statement (Lee and Orr-Weaver, 2003) cullin-RING ubiquitin ligase complex inferred from electronic annotation with InterPro:IPR001373, InterPro:IPR016158 (FlyBase Curators et al., 2004-)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions mr allele Gene References mr1 CycB (Kashevsky et al., 2002) e(mr) (Reed, 1992) mr2 e(mr) (Reed, 1992) mr3 CycB (Kashevsky et al., 2002) Liprin-α (van Roessel et al., 2004)
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 69972 DroID - A comprehensive database of gene and protein interactions. • FBgn0002791 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 45906
Orthologs
Genome-wide drosophilid orthologs	Dana\GF12886 Dere\GG22916 Dgri\GH20172 Dmoj\GI20702 Dper\GL11645 Dpse\GA15898 Dsec\GM16075 Dsim\GD11818 Dvir\GJ21890 Dwil\GK15727 Dyak\GE14353
Curated drosophilid orthologs	Dpse\GA15898
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL001756-PA Aedes aegypti (mosquito) AGAP005048-PA Anopheles gambiae (mosquito) XP_395411.2 Apis mellifera (honey bee) XP_001946043.1 Acyrthosiphon pisum (pea aphid) At2g04660.1 Arabidopsis thaliana (wall cress) 92557 Batrachochytrium dendrobatidis (chytrid fungus) 118263 Branchiostoma floridae (lancelet) 229665 Branchiostoma floridae (lancelet) XP_001894849.1 Brugia malayi (roundworm nematode) BGIBMGA005147-PA Bombyx mori (silk worm) CAL0005690 Candida albicans (a form of yeast) CN13924 Caenorhabditis brenneri (small nematode) CBP26223 Caenorhabditis briggsae (nematode) CE41679 Caenorhabditis elegans (worm) ENSCAFP00000028810 Canis familiaris (dog) CAGL0M04235g Candida glabrata (haploid yeast) ENSCINP00000005419 Ciona intestinalis (sea squirt) JA01914 Caenorhabditis japonica (nematode) CMC102C Cyanidioschyzon merolae (red alga) cn14243 Cryptococcus neoformans (yeast-like fungus) CPIJ003980 Culex pipens (mosquito) ENSCPOP00000008758 Cavia porcellus (guinea pig) RP25411 Caenorhabditis remanei (nematode) DDB0234264 Dictyostelium discoideum (amoeba) DEHA2F04642g Debaryomyces Hansenii (yeast) 311756 Daphnia pulex (daphnia) ENSDARP00000021858 Danio rerio (zebra fish) ENSECAP00000016834 Equus caballus (horse) ENSGACP00000019694 Gymnopilus aculeatus (mushroom) ENSGALP00000014037 Gallus gallus (chicken) 73864 Hypsipyla robusta (cedar shoot borer) ENSP00000314004 Homo sapiens (human) 109593 Lottia gigantea (owl limpet) LmjF35.3750 Leishmania major (virus) 28655 Monocosta brevicollis (choanoflagellate) ENSMODP00000021443 Monodelphis domestica (gray opossum) ENSMMUP00000002241 Macaca mulatta (rhesus monkey) ENSMUSP00000028341 Mus musculus (house mouse) 130907 Nematostella vectensis (starlet anemone) XP_001605994.1 Nasonia vitripennis (wasp) ENSORLP00000001375 Oryzias latipes (japanese killifish) LOC_Os04g40830.1 Oryza sativa (asian rice) 19952 Ostreococcus tauri (green alga) PHUM000369-PA Pediculus humanus (human body louse) 178604 Physcomitrella patens (moss) ENSPPYP00000022215 Pongo pygmaeus (orangutan) 77424 Phytophthora ramorum (sudden oak death pathogen) 139935 Phytophthora sojae (root rot pathogen) 832637 Populus trichocarpa (black cottonwood) ENSPTRP00000036989 Pan troglodytes (chimpanzee) ENSRNOP00000015099 Rattus norvegicus (norway rat) 4861941 Sorghum bicolor (sorghum) YLR127C Saccharomyces cerevisiae (budding yeast) Smp_152400 Schistosoma mansoni (trematode parasite) SPBP23A10.04 Schizosaccharomyces pombe (fission yeast) XP_795679.2 Strongylocentrotus purpuratus (purple sea urchin) 28922 Trichoplax adhaerens (metazoa) XP_975471.2 Tribolium castaneum (red flour beetle) Tc00.1047053508461.520 Trypanosoma cruzi (parasitic trypanosome) ENSTNIP00000014238 Tetraodon nigroviridis (green spotted pufferfish) 6167 Thalassiosira pseudonana (marine diatom) ENSTRUP00000008093 Takifugu rubripes (pufferfish Takifugu) 3683.m00006 Tetrahymena thermophila (ciliate protozoa) 87848.m00043 Trichomonas vaginalis (parasitic flagellated protozoan) ENSXETP00000049599 Xenopus tropicalis (frog) YALI0E04983g Yarrowia lipolytica (nonconventional yeast) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB16530 NV16511 LH24364 FBgn0231965 FBgn0217730 FBgn0209007 FBgn0183557 FBgn0170991 FBgn0166894 JGI_V11_311756 FBgn0075914 FBgn0149254 FBgn0143437 FBgn0127636 FBgn0115073 FBgn0089920 CPIJ003980 BGIBMGA005147 ACYPI005286 GB14760 AGAP005048 AAEL001756 PHUM427340 GLEAN_02887
Stocks & Reagents
Stocks Listed in FlyBase ( 15 )
Bloomington	4535 e(mr)1; mr2/SM6a 19840 y1 w67c23; P{EPgy2}mrEY04503 14554 y1 w67c23; P{SUPor-P}mrKG07756 257 chl1 l(2)bw1 bw2b mr2/SM5 351 mr1 bs2/In(2LR)bwV1, ds33k bwV1 817 In(2L)NS, In(2R)NS, b1 l(2)35De1 mr1/In(2L)Cy, In(2R)Cy, Cy1
Kyoto	107785 e(mr)1; mr2/SM6a 125827 w1118; P{RS5}mr5-SZ-3002 101509 In(2L)Cy In(2R)Cy, Cy1 cn2 / In(2L)NS In(2R)NS, b1 mr1
VDRC	v106986 P{KK100791}VIE-260B v2993 w1118; P{GD1489}v2993 v2994 w1118; P{GD1489}v2994
	More stocks available...
Genomic Clones ( 1 )
	BACR28M05 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 29 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	LD21042 LD45730
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	LD13715 LD16662 LD17073 LD18163 LD24966 LD30594 LD39911 RE24181 RE39264 RE53018 RE57353 RE61612 RE74282 SD09172
Other clones	77866 121199 161287 214537.81 EK055504 EK065504 EK241129 EK265041 EP19748 IP03770 IP03870 IP03970 LD24965
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0002791 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 45906
Antibody Information
Other Information
Discoverer
	Bridges, 8th March 1913.
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of	Source for merge of: mr CG3060 (FlyBase, 1996-)
Additional comments	Source for merge of mr CG3060 was sequence comparison (date:021108). (FlyBase, 1996-)
Other Comments
	mr has a postmitotic role in neuromuscular synapses; in the neurons mr controls synaptic size, while in muscles, mr regulates synaptic transmission, controlling the concentration of GluRIIA protein. (van Roessel et al., 2004) mr is required to maintain the absence of mitosis during the endo cycle, and is also necessary for dividing cells to exit mitosis. (Reed and Orr-Weaver, 1997) mr is required for the maintenance of endomitosis in the nurse cells of the adult female ovary. Nurse cells of hypomorphic alleles revert to a mitotic-like state instead of going on to become highly polyploid. (Reed and Orr-Weaver, 1995)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_138018 RefSeq (Proteins) • NP_611862 DDBJ / EMBL / GenBank • AA541203 AA820997 AAF47123 AAL13946 AAM97765 AI455568 AI513454 AW943800 AY058717 AY129297 BH854685 CL705790 Entrez Gene - A searchable database of RefSeq genes. • 45906 UniProtKB/TrEMBL • Q9W1E5 Q95TK2
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Cullin, N-terminal (IPR001373) Anaphase-promoting complex subunit 2, C-terminal (IPR014786) Cullin homology (IPR016158) Winged helix-turn-helix transcription repressor DNA-binding (IPR011991)
Linkouts
	BioGRID - A database of protein and genetic interactions • 69972 DroID - A comprehensive database of gene and protein interactions. • FBgn0002791 DRSC - Results from RNAi screens. • FBgn0002791 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0002791 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG3060-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0002791 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 45906 InParanoid A subset of ortholog calls from InParanoid. • AAEL001756-PA Aedes aegypti (mosquito) AGAP005048-PA Anopheles gambiae (mosquito) XP_395411.2 Apis mellifera (honey bee) XP_001946043.1 Acyrthosiphon pisum (pea aphid) At2g04660.1 Arabidopsis thaliana (wall cress) 92557 Batrachochytrium dendrobatidis (chytrid fungus) 118263 Branchiostoma floridae (lancelet) 229665 Branchiostoma floridae (lancelet) XP_001894849.1 Brugia malayi (roundworm nematode) BGIBMGA005147-PA Bombyx mori (silk worm) CAL0005690 Candida albicans (a form of yeast) CN13924 Caenorhabditis brenneri (small nematode) CBP26223 Caenorhabditis briggsae (nematode) CE41679 Caenorhabditis elegans (worm) ENSCAFP00000028810 Canis familiaris (dog) CAGL0M04235g Candida glabrata (haploid yeast) ENSCINP00000005419 Ciona intestinalis (sea squirt) JA01914 Caenorhabditis japonica (nematode) CMC102C Cyanidioschyzon merolae (red alga) cn14243 Cryptococcus neoformans (yeast-like fungus) CPIJ003980 Culex pipens (mosquito) ENSCPOP00000008758 Cavia porcellus (guinea pig) RP25411 Caenorhabditis remanei (nematode) DDB0234264 Dictyostelium discoideum (amoeba) DEHA2F04642g Debaryomyces Hansenii (yeast) 311756 Daphnia pulex (daphnia) ENSDARP00000021858 Danio rerio (zebra fish) ENSECAP00000016834 Equus caballus (horse) ENSGACP00000019694 Gymnopilus aculeatus (mushroom) ENSGALP00000014037 Gallus gallus (chicken) 73864 Hypsipyla robusta (cedar shoot borer) ENSP00000314004 Homo sapiens (human) 109593 Lottia gigantea (owl limpet) LmjF35.3750 Leishmania major (virus) 28655 Monocosta brevicollis (choanoflagellate) ENSMODP00000021443 Monodelphis domestica (gray opossum) ENSMMUP00000002241 Macaca mulatta (rhesus monkey) ENSMUSP00000028341 Mus musculus (house mouse) 130907 Nematostella vectensis (starlet anemone) XP_001605994.1 Nasonia vitripennis (wasp) ENSORLP00000001375 Oryzias latipes (japanese killifish) LOC_Os04g40830.1 Oryza sativa (asian rice) 19952 Ostreococcus tauri (green alga) PHUM000369-PA Pediculus humanus (human body louse) 178604 Physcomitrella patens (moss) ENSPPYP00000022215 Pongo pygmaeus (orangutan) 77424 Phytophthora ramorum (sudden oak death pathogen) 139935 Phytophthora sojae (root rot pathogen) 832637 Populus trichocarpa (black cottonwood) ENSPTRP00000036989 Pan troglodytes (chimpanzee) ENSRNOP00000015099 Rattus norvegicus (norway rat) 4861941 Sorghum bicolor (sorghum) YLR127C Saccharomyces cerevisiae (budding yeast) Smp_152400 Schistosoma mansoni (trematode parasite) SPBP23A10.04 Schizosaccharomyces pombe (fission yeast) XP_795679.2 Strongylocentrotus purpuratus (purple sea urchin) 28922 Trichoplax adhaerens (metazoa) XP_975471.2 Tribolium castaneum (red flour beetle) Tc00.1047053508461.520 Trypanosoma cruzi (parasitic trypanosome) ENSTNIP00000014238 Tetraodon nigroviridis (green spotted pufferfish) 6167 Thalassiosira pseudonana (marine diatom) ENSTRUP00000008093 Takifugu rubripes (pufferfish Takifugu) 3683.m00006 Tetrahymena thermophila (ciliate protozoa) 87848.m00043 Trichomonas vaginalis (parasitic flagellated protozoan) ENSXETP00000049599 Xenopus tropicalis (frog) YALI0E04983g Yarrowia lipolytica (nonconventional yeast) Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution • /newgene/morula1.htm InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 45906 modMine - Data generated by the modENCODE project. • FBgn0002791 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB16530 NV16511 LH24364 FBgn0231965 FBgn0217730 FBgn0209007 FBgn0183557 FBgn0170991 FBgn0166894 JGI_V11_311756 FBgn0075914 FBgn0149254 FBgn0143437 FBgn0127636 FBgn0115073 FBgn0089920 CPIJ003980 BGIBMGA005147 ACYPI005286 GB14760 AGAP005048 AAEL001756 PHUM427340 GLEAN_02887
Synonyms & Secondary IDs ( 8 )
Reported As
Symbol Synonym	APC2 (Zielke et al., 2008, Buttitta et al., 2010, Silies and Klämbt, 2010) Apc2 (Tanaka-Matakatsu et al., 2007, Narbonne-Reveau et al., 2008) APC2/mr (van Roessel et al., 2004) CG3060 (Harper et al., 2002, Keleman et al., 2009.8.5) dAPC2 (Chen et al., 2009) mr (Sugimura and Lilly, 2006, Christensen et al., 2008.10.20, Pesin and Orr-Weaver, 2007, Slack et al., 2007, Narbonne-Reveau et al., 2008, Zielke et al., 2008, Christensen et al., 2009.2.28, Vardy et al., 2009, Chen et al., 2009, Tanaka-Matakatsu et al., 2007, Buttitta et al., 2010, Silies and Klämbt, 2010)
Name Synonym	morula (Pesin and Orr-Weaver, 2007, Slack et al., 2007, Narbonne-Reveau et al., 2008, Zielke et al., 2008, Vardy et al., 2009, Chen et al., 2009, Silies and Klämbt, 2010) Morula (Acquaviva and Pines, 2006)
Secondary FlyBase IDs
	FBgn0034947
References ( 55 )
Generate a list of	All references relating to this gene ( 55 )
List References by type	Research paper  ( 22 ) Supplementary material  ( 5 ) Review  ( 6 ) Personal communication to FlyBase  ( 7 ) Abstract  ( 5 ) FlyBase analysis  ( 3 ) DNA/RNA sequence record  ( 1 ) Thesis  ( 1 ) Book  ( 2 ) Computer file  ( 2 ) Curated genome annotation  ( 1 )
Recent research papers ( 2 )
	Buttitta et al., 2010, J. Cell Biol. 189(6): 981--996 A robust cell cycle control mechanism limits E2F-induced proliferation of terminally differentiated cells in vivo. [FBrf0211029] Silies and Klämbt, 2010, Nat. Neurosci. 13(11): 1357--1364 APC/C(Fzr/Cdh1)-dependent regulation of cell adhesion controls glial migration in the Drosophila PNS. [FBrf0212144] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2010 Show reviews ...