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Gene Dmel\sa

General Information
Symbol	Dmel\sa	Species	D. melanogaster
Name	spermatocyte arrest	Annotation symbol	CG11308
Feature type	protein_coding_gene	FlyBase ID	FBgn0002842
Gene Model Status	Current	Stock availability	7 publicly available
Genomic Location
Chromosome (arm)	3L	Recombination map	3-44
Cytogenetic map	78D1-78D1	Sequence location	3L:21,398,525..21,399,875 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene spermatocyte arrest is referred to in FlyBase by the symbol Dmel\sa (CG11308, FBgn0002842). It is a protein_coding_gene from Drosophila melanogaster. Its molecular function is unknown. There is experimental evidence that it is involved in the biological process: male meiosis I; spermatid differentiation; regulation of gene expression; spermatogenesis. 8 alleles are reported. The phenotypes of these alleles are annotated with: testis; spermatocyte. It has one annotated transcript and one annotated polypeptide. Protein features are: Bromodomain transcription factor; Transcription factor TFIID, subunit 8, C-terminal. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of no expression detected. Peak expression observed in adult male stages. Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: adult testis. Comments on Affy2 ProbeSet: ProbeSet 1632138_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of sa. Gene sequence location is 3L:21398525..21399875.
Phenotypic Description from the Red Book (Lindsley & Zimm 1992)
Gene/Allele symbols may differ from current usage	ms(3)sa: male sterile (3) spermatocyte arrest Primary spermatocytes arrested premeiotically but apparently after attaining full size; testes become filled with mature primary spermatocytes.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2012_01	References White-Cooper, 2010, Reproduction 139(1): 11--21 Sequence features BKN26263 HFA11649 Controlled Vocabulary Terms spermatid differentiation regulation of gene expression male germ cell nucleus
FB2011_10
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 78D1-78D1   Limits computationally determined from genome sequence between P{lacW}l(3)j1B10j1B10 and P{lacW}l(3)j2C4j2C4
Experimentally Determined Cytological Location
Cytogenetic map Notes References 78A-78D   (determined by in situ hybridisation)   (Lin et al., 1995)
Experimentally Determined Recombination Data
Location	3-44
Left of (cM)
Right of (cM)
Notes	Mapped by Kemphues.   sa1 is inseparable from kni+ in seven recombinants in the st-pp interval between a sa1 and a st, kni, pp chromosome. (Lin et al., 1996)
Gene Model & Products
Please see the GBrowse view of Dmel\sa for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.40
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) sa-RA FBtr0078401  NM_141054   993   275
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein sa-PA   FBpp0078055   31.1   275   4.87     NP_649311   AAF51716
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Bromodomain transcription factor (IPR006565) Transcription factor TFIID, subunit 8, C-terminal (IPR019473)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AE014296 AAF51716   AY752879 AAV33344   BT023594   EL879446   EL879568
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q9VP40
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0002842    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0002842 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of no expression detected. Peak expression observed in adult male stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0002842 expression level Developmental Stage   Expression Level embryo 00-02hr    1 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    1 embryo 08-10hr    2 embryo 10-12hr    0 embryo 12-14hr    0 embryo 14-16hr    5 embryo 16-18hr    7 embryo 18-20hr    19 embryo 20-22hr    2 embryo 22-24hr    14 larva L1    17 larva L2    7 larva L3 12hr old    62 larva L3 puffstage 1-2    334 larva L3 puffstage 3-6    473 larva L3 puffstage 7-9    504 white prepupae new    577 white prepupae 12hr    749 white prepupae 24hr    951 pupae 2d postWPP    838 pupae 3d postWPP    597 pupae 4d postWPP    530 adult male 01day    971 adult male 05day    1706 adult male 30day    1433 adult female 01day    7 adult female 05day    7 adult female 30day    3 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr    1 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    1 embryo 08-10hr    2 embryo 10-12hr    0 embryo 12-14hr    0 embryo 14-16hr    5 embryo 16-18hr    7 embryo 18-20hr    19 embryo 20-22hr    2 embryo 22-24hr    14 larva L1    17 larva L2    7 larva L3 12hr old    62 larva L3 puffstage 1-2  (334) larva L3 puffstage 3-6  (473) larva L3 puffstage 7-9  (504) white prepupae new  (577) white prepupae 12hr  (749) white prepupae 24hr  (951) pupae 2d postWPP  (838) pupae 3d postWPP  (597) pupae 4d postWPP  (530) adult male 01day  (971) adult male 05day  (1706) adult male 30day  (1433) adult female 01day    7 adult female 05day    7 adult female 30day    3 Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    1 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    1 embryo 08-10hr    2 embryo 10-12hr    0 embryo 12-14hr    0 embryo 14-16hr    5 embryo 16-18hr    7 embryo 18-20hr    19 embryo 20-22hr    2 embryo 22-24hr    14 larva L1    17 larva L2    7 larva L3 12hr old    62 larva L3 puffstage 1-2    334 larva L3 puffstage 3-6    473 larva L3 puffstage 7-9    504 white prepupae new    577 white prepupae 12hr    749 white prepupae 24hr    951 pupae 2d postWPP    838 pupae 3d postWPP    597 pupae 4d postWPP    530 adult male 01day    971 adult male 05day  (1706) adult male 30day  1433 adult female 01day    7 adult female 05day    7 adult female 30day    3 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    1 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    1 embryo 08-10hr    2 embryo 10-12hr    0 embryo 12-14hr    0 embryo 14-16hr    5 embryo 16-18hr    7 embryo 18-20hr    19 embryo 20-22hr    2 embryo 22-24hr    14 larva L1    17 larva L2    7 larva L3 12hr old    62 larva L3 puffstage 1-2    334 larva L3 puffstage 3-6    473 larva L3 puffstage 7-9    504 white prepupae new    577 white prepupae 12hr    749 white prepupae 24hr    951 pupae 2d postWPP    838 pupae 3d postWPP    597 pupae 4d postWPP    530 adult male 01day    971 adult male 05day    1706 adult male 30day    1433 adult female 01day    7 adult female 05day    7 adult female 30day    3 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    1 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    1 embryo 08-10hr    2 embryo 10-12hr    0 embryo 12-14hr    0 embryo 14-16hr    5 embryo 16-18hr    7 embryo 18-20hr    19 embryo 20-22hr    2 embryo 22-24hr    14 larva L1    17 larva L2    7 larva L3 12hr old    62 larva L3 puffstage 1-2    334 larva L3 puffstage 3-6    473 larva L3 puffstage 7-9    504 white prepupae new    577 white prepupae 12hr    749 white prepupae 24hr    951 pupae 2d postWPP    838 pupae 3d postWPP    597 pupae 4d postWPP    530 adult male 01day    971 adult male 05day    1706 adult male 30day    1433 adult female 01day    7 adult female 05day    7 adult female 30day    3 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0002842 expression level Developmental Stage   Expression Level embryo 00-02hr    1 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    1 embryo 08-10hr    2 embryo 10-12hr    0 embryo 12-14hr    0 embryo 14-16hr    5 embryo 16-18hr    7 embryo 18-20hr    19 embryo 20-22hr    2 embryo 22-24hr    14 larva L1    17 larva L2    7 larva L3 12hr old    62 larva L3 puffstage 1-2    334 larva L3 puffstage 3-6    473 larva L3 puffstage 7-9    504 white prepupae new    577 white prepupae 12hr    749 white prepupae 24hr    951 pupae 2d postWPP    838 pupae 3d postWPP    597 pupae 4d postWPP    530 adult male 01day    971 adult male 05day    1706 adult male 30day    1433 adult female 01day    7 adult female 05day    7 adult female 30day    3 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr    1 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    1 embryo 08-10hr    2 embryo 10-12hr    0 embryo 12-14hr    0 embryo 14-16hr    5 embryo 16-18hr    7 embryo 18-20hr    19 embryo 20-22hr    2 embryo 22-24hr    14 larva L1    17 larva L2    7 larva L3 12hr old    62 larva L3 puffstage 1-2  (334) larva L3 puffstage 3-6  (473) larva L3 puffstage 7-9  (504) white prepupae new  (577) white prepupae 12hr  (749) white prepupae 24hr  (951) pupae 2d postWPP  (838) pupae 3d postWPP  (597) pupae 4d postWPP  (530) adult male 01day  (971) adult male 05day  (1706) adult male 30day  (1433) adult female 01day    7 adult female 05day    7 adult female 30day    3 Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    1 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    1 embryo 08-10hr    2 embryo 10-12hr    0 embryo 12-14hr    0 embryo 14-16hr    5 embryo 16-18hr    7 embryo 18-20hr    19 embryo 20-22hr    2 embryo 22-24hr    14 larva L1    17 larva L2    7 larva L3 12hr old    62 larva L3 puffstage 1-2    334 larva L3 puffstage 3-6    473 larva L3 puffstage 7-9    504 white prepupae new    577 white prepupae 12hr    749 white prepupae 24hr    951 pupae 2d postWPP    838 pupae 3d postWPP    597 pupae 4d postWPP    530 adult male 01day    971 adult male 05day  1706 adult male 30day  1433 adult female 01day    7 adult female 05day    7 adult female 30day    3 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    1 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    1 embryo 08-10hr    2 embryo 10-12hr    0 embryo 12-14hr    0 embryo 14-16hr    5 embryo 16-18hr    7 embryo 18-20hr    19 embryo 20-22hr    2 embryo 22-24hr    14 larva L1    17 larva L2    7 larva L3 12hr old    62 larva L3 puffstage 1-2    334 larva L3 puffstage 3-6    473 larva L3 puffstage 7-9    504 white prepupae new    577 white prepupae 12hr    749 white prepupae 24hr    951 pupae 2d postWPP    838 pupae 3d postWPP    597 pupae 4d postWPP    530 adult male 01day    971 adult male 05day    1706 adult male 30day    1433 adult female 01day    7 adult female 05day    7 adult female 30day    3 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    1 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    1 embryo 08-10hr    2 embryo 10-12hr    0 embryo 12-14hr    0 embryo 14-16hr    5 embryo 16-18hr    7 embryo 18-20hr    19 embryo 20-22hr    2 embryo 22-24hr    14 larva L1    17 larva L2    7 larva L3 12hr old    62 larva L3 puffstage 1-2    334 larva L3 puffstage 3-6    473 larva L3 puffstage 7-9    504 white prepupae new    577 white prepupae 12hr    749 white prepupae 24hr    951 pupae 2d postWPP    838 pupae 3d postWPP    597 pupae 4d postWPP    530 adult male 01day    971 adult male 05day    1706 adult male 30day    1433 adult female 01day    7 adult female 05day    7 adult female 30day    3 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0002842    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0002842 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: adult testis. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0002842 expression level Tissue   Expression Level Larval Central Nervous System    1.35 Larval Midgut    3.3 Larval Hindgut    4.7 Larval Malpighian Tubules    4 Larval Fat Body no informative data Larval Salivary Gland    3.8 Larval Trachea    2.175 Larval Carcass    1.925 Adult Head    0.8 Adult Eye    2.225 Adult Brain    1 Adult Thoracic-Abdominal Ganglion    4.8 Adult Crop    3.9 Adult Midgut    1.8 Adult Hindgut    1.9 Adult Malpighian Tubules    2.8 Adult Fat Body    1 Adult Salivary Gland    3.4 Adult Heart    0.675 Adult VirginFemale Spermatheca    3.3 Adult InseminatedFemale Spermatheca    1.3 Adult Ovary    2 Adult Testis    254.4 Adult Male Accessory Gland    8 Adult Carcass    2 Expression Level Scale  None   Low   Moderate  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    1.35 Larval Midgut    3.3 Larval Hindgut    4.7 Larval Malpighian Tubules    4 Larval Fat Body no informative data Larval Salivary Gland    3.8 Larval Trachea    2.175 Larval Carcass    1.925 Adult Head    0.8 Adult Eye    2.225 Adult Brain    1 Adult Thoracic-Abdominal Ganglion    4.8 Adult Crop    3.9 Adult Midgut    1.8 Adult Hindgut    1.9 Adult Malpighian Tubules    2.8 Adult Fat Body    1 Adult Salivary Gland    3.4 Adult Heart    0.675 Adult VirginFemale Spermatheca    3.3 Adult InseminatedFemale Spermatheca    1.3 Adult Ovary    2 Adult Testis    254.4 Adult Male Accessory Gland    8 Adult Carcass    2 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    1.35 Larval Midgut    3.3 Larval Hindgut    4.7 Larval Malpighian Tubules    4 Larval Fat Body no informative data Larval Salivary Gland    3.8 Larval Trachea    2.175 Larval Carcass    1.925 Adult Head    0.8 Adult Eye    2.225 Adult Brain    1 Adult Thoracic-Abdominal Ganglion    4.8 Adult Crop    3.9 Adult Midgut    1.8 Adult Hindgut    1.9 Adult Malpighian Tubules    2.8 Adult Fat Body    1 Adult Salivary Gland    3.4 Adult Heart    0.675 Adult VirginFemale Spermatheca    3.3 Adult InseminatedFemale Spermatheca    1.3 Adult Ovary    2 Adult Testis    254.4 Adult Male Accessory Gland    8 Adult Carcass    2 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    1.35 Larval Midgut    3.3 Larval Hindgut    4.7 Larval Malpighian Tubules    4 Larval Fat Body no informative data Larval Salivary Gland    3.8 Larval Trachea    2.175 Larval Carcass    1.925 Adult Head    0.8 Adult Eye    2.225 Adult Brain    1 Adult Thoracic-Abdominal Ganglion    4.8 Adult Crop    3.9 Adult Midgut    1.8 Adult Hindgut    1.9 Adult Malpighian Tubules    2.8 Adult Fat Body    1 Adult Salivary Gland    3.4 Adult Heart    0.675 Adult VirginFemale Spermatheca    3.3 Adult InseminatedFemale Spermatheca    1.3 Adult Ovary    2 Adult Testis    254.4 Adult Male Accessory Gland    8 Adult Carcass    2 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0002842 expression level Tissue   Expression Level Larval Central Nervous System    1.35 Larval Midgut    3.3 Larval Hindgut    4.7 Larval Malpighian Tubules    4 Larval Fat Body no informative data Larval Salivary Gland    3.8 Larval Trachea    2.175 Larval Carcass    1.925 Adult Head    0.8 Adult Eye    2.225 Adult Brain    1 Adult Thoracic-Abdominal Ganglion    4.8 Adult Crop    3.9 Adult Midgut    1.8 Adult Hindgut    1.9 Adult Malpighian Tubules    2.8 Adult Fat Body    1 Adult Salivary Gland    3.4 Adult Heart    0.675 Adult VirginFemale Spermatheca    3.3 Adult InseminatedFemale Spermatheca    1.3 Adult Ovary    2 Adult Testis    254.4 Adult Male Accessory Gland    8 Adult Carcass    2 Expression Level Scale  None   Low   Moderate  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    1.35 Larval Midgut    3.3 Larval Hindgut    4.7 Larval Malpighian Tubules    4 Larval Fat Body no informative data Larval Salivary Gland    3.8 Larval Trachea    2.175 Larval Carcass    1.925 Adult Head    0.8 Adult Eye    2.225 Adult Brain    1 Adult Thoracic-Abdominal Ganglion    4.8 Adult Crop    3.9 Adult Midgut    1.8 Adult Hindgut    1.9 Adult Malpighian Tubules    2.8 Adult Fat Body    1 Adult Salivary Gland    3.4 Adult Heart    0.675 Adult VirginFemale Spermatheca    3.3 Adult InseminatedFemale Spermatheca    1.3 Adult Ovary    2 Adult Testis    254.4 Adult Male Accessory Gland    8 Adult Carcass    2 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    1.35 Larval Midgut    3.3 Larval Hindgut    4.7 Larval Malpighian Tubules    4 Larval Fat Body no informative data Larval Salivary Gland    3.8 Larval Trachea    2.175 Larval Carcass    1.925 Adult Head    0.8 Adult Eye    2.225 Adult Brain    1 Adult Thoracic-Abdominal Ganglion    4.8 Adult Crop    3.9 Adult Midgut    1.8 Adult Hindgut    1.9 Adult Malpighian Tubules    2.8 Adult Fat Body    1 Adult Salivary Gland    3.4 Adult Heart    0.675 Adult VirginFemale Spermatheca    3.3 Adult InseminatedFemale Spermatheca    1.3 Adult Ovary    2 Adult Testis    254.4 Adult Male Accessory Gland    8 Adult Carcass    2 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    1.35 Larval Midgut    3.3 Larval Hindgut    4.7 Larval Malpighian Tubules    4 Larval Fat Body no informative data Larval Salivary Gland    3.8 Larval Trachea    2.175 Larval Carcass    1.925 Adult Head    0.8 Adult Eye    2.225 Adult Brain    1 Adult Thoracic-Abdominal Ganglion    4.8 Adult Crop    3.9 Adult Midgut    1.8 Adult Hindgut    1.9 Adult Malpighian Tubules    2.8 Adult Fat Body    1 Adult Salivary Gland    3.4 Adult Heart    0.675 Adult VirginFemale Spermatheca    3.3 Adult InseminatedFemale Spermatheca    1.3 Adult Ovary    2 Adult Testis    254.4 Adult Male Accessory Gland    8 Adult Carcass    2 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body no informative data Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    0.8   NA  Eye    2.225   NA  Brain    1   1.35  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    4.8   NA  Crop    3.9   3.3  Midgut    1.8   4.7  Hindgut    1.9   4  Malpighian Tubules    2.8   no informative data  Fat Body    1   3.8  Salivary Gland    3.4   NA  Heart    0.675   2.175  Trachea    NA   NA  VirginFemale Spermatheca    3.3   NA  InseminatedFemale Spermatheca    1.3   NA  Ovary    2   NA  Testis    254.4   NA  Male Accessory Gland    8   1.925  Carcass    2 modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0002842 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG11308-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele viable, with Scer\GAL4pnr-MD237 saGD7265 Sterility Allele male sterile (with sa1) sa2 male sterile (with sa2) sa1 male sterile | recessive sa1 sa2 Other Phenotypes Allele meiotic cell cycle defective | recessive sa1 sa2 Phenotype manifest in Allele spermatocyte sa1 sa2 spermatocyte (with sa1) sa2 spermatocyte (with sa2) sa1 testis sa1 sa2 testis (with sa1) sa2 testis (with sa2) sa1
Classical Alleles ( 4 )
For All Classical Alleles Show
Allele of sa Class Mutagen Stocks Known lesion sa1 spontaneous 5 Yes saMB02115 1 -- sa2 ethyl methanesulfonate 0 Yes saunspecified 0 --
Alleles Carried on Transgenic Constructs ( 4 )
For All Alleles Carried on Transgenic Constructs Show
Allele of sa Class Mutagen Stocks Known lesion saGD7265 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes sa+t3.2 in vitro construct - genomic fragment 0 Yes saT:Avic\GFP-EGFP in vitro construct - coding region fusion 0 Yes saT:Ivir\HA1 in vitro construct - coding region fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(3L)Pc-MK (Lin et al., 1996)
Not disrupted in	Df(3L)Pc (Lin et al., 1996)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD7265} NA characterization construct P{sa-3HA} NA P{sa.3.2} NA P{sa-EGFP} NA
Insertions
	Type of insertions Name Expression data insertion of enhancer trap binary system Mi{ET1}rgnMB02115 No
Gene Ontology: Function, Process & Cellular Component ( 8 unique terms )
Terms Based on Experimental Evidence ( 6 terms )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
male meiosis I inferred from mutant phenotype (Lin et al., 1996) regulation of gene expression inferred from mutant phenotype (White-Cooper et al., 1998) spermatid differentiation inferred from mutant phenotype (White-Cooper et al., 1998) spermatogenesis inferred from mutant phenotype (Lin et al., 1996, Hiller et al., 2004)
Cellular Component
CV term Evidence References
male germ cell nucleus inferred from direct assay (Chen et al., 2005) nucleolus inferred from direct assay (Chen et al., 2005)
Terms Based on Predictions or Assertions ( 2 terms )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
meiosis traceable author statement (Fuller, 1998) spermatid development traceable author statement (Fuller, 1998)
Cellular Component ( 0 terms)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions sa allele Gene References unspecified twe (Lin et al., 1996)
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 65614 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0002842 DroID - A comprehensive database of gene and protein interactions. • FBgn0002842 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 40367
Orthologs
Genome-wide drosophilid orthologs	Dana\GF24194 Dere\GG13239 Dgri\GH14693 Dmoj\GI13306 Dper\GL24583 Dpse\GA10905 Dsec\GM22142 Dsim\GD12120 Dvir\GJ12076 Dwil\GK20419 Dyak\GE22337
Curated drosophilid orthologs	Dpse\GA10905
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • XP_656311 Entamoeba histolytica (anaerobic protozoan) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • FBgn0239920 FBgn0239560 FBgn0222416 FBgn0199328 FBgn0183857 FBgn0177013 FBgn0070961 FBgn0162172 FBgn0136063 FBgn0122169 FBgn0105511 FBgn0101188
Stocks & Reagents
Stocks Listed in FlyBase ( 7 )
Bloomington	1762 sa1 red1/TM3, Sb1 23788 w1118; Mi{ET1}rgnMB02115 saMB02115 1618 y1; l(2)**/CyO; sa1/TM6; svspa-pol 1763 C(1;Y)*, y1/0; sa1 red1/TM6 & C(1)*, y1/0; sa1 red1/TM6
Kyoto	106494 sa1 red1/TM3, Sb1 106419 y1; l(2)**/CyO; sa1/TM6; svspa-pol
VDRC	v31487 w1118; P{GD7265}v31487/TM3
Genomic Clones ( 2 )
	BACR03O18 BACR25G05 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 4 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	IP09318
Other clones	DPiM_IP09318
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones
Other clones	IP09418 IP09518
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0002842 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 40367
Antibody Information
	polyclonal (Doggett et al., 2011)
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of	Source for merge of: sa CG11308 (Hiller et al., 2004)
Additional comments
Other Comments
	Mutant allele fails to complement a QTL affecting male mating behaviour. (Moehring and Mackay, 2004) can, mia and sa are required for accumulation of tweT:Ecol\lacZ transgene in late primary spermatocytes. (White-Cooper et al., 1998) Wild type function of aly, can, mia and sa is required for cell-cycle progression through the G2/M transition of meiosis I in males and for onset of spermatid differentiation. Mutations in can and sa are epistatic to mutations in twe. The phenotype of these meiotic arrest mutants is strikingly similar to the histopathological features of meiosis I maturation arrest infertility in human males, suggesting that the control point may be conserved from flies to man. (Lin et al., 1996) sa is required for both the progression of the male meiotic cell cycle and the onset of postmeiotic differentiation. (Lin et al., 1995) Mutations of sa affect the morphology and behaviour of the mitotic spindles of embryonic cleavage divisions to produce multipolar spindles in male meiosis and generate abnormal mitotic figures in larval neuroblasts. (Wilson and Fuller, 1991)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_141054 RefSeq (Proteins) • NP_649311 DDBJ / EMBL / GenBank • AAF51716 AAV33344 AY752879 Entrez Gene - A searchable database of RefSeq genes. • 40367 UniProtKB/TrEMBL • Q9VP40
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Bromodomain transcription factor (IPR006565) Transcription factor TFIID, subunit 8, C-terminal (IPR019473)
Linkouts
	BioGRID - A database of protein and genetic interactions • 65614 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0002842 DroID - A comprehensive database of gene and protein interactions. • FBgn0002842 DRSC - Results from RNAi screens. • FBgn0002842 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0002842 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG11308-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0002842 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 40367 InParanoid A subset of ortholog calls from InParanoid. • XP_656311 Entamoeba histolytica (anaerobic protozoan) InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 40367 modMine - Data generated by the modENCODE project. • FBgn0002842 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • FBgn0239920 FBgn0239560 FBgn0222416 FBgn0199328 FBgn0183857 FBgn0177013 FBgn0070961 FBgn0162172 FBgn0136063 FBgn0122169 FBgn0105511 FBgn0101188
Synonyms & Secondary IDs ( 15 )
Reported As
Symbol Synonym	CG11308 (Moehring and Mackay, 2004, Giot et al., 2003, Vibranovski et al., 2009) dTAF8L (Hiller et al., 2004) gfb   ms(3)sa (Fuller, 1993, ) ms(3)VO5   ms(3)VO45   sa (Rautureau et al., 2009, Ceulemans, 2006, Arya et al., 2006, Boutanaev et al., 2007, Gan et al., 2010, Chen et al., 2005, Chen et al., 2005, Metcalf and Wassarman, 2007, Moon et al., 2011, Vibranovski et al., 2009, Insco et al., 2009, Di Cara et al., 2010, Gan et al., 2010, Doggett et al., 2011, White-Cooper, 2010) Sa (Ringrose, 2006, Mikhaylova et al., 2006, Insco et al., 2009) TAF8L (Turk and Hiller, 2006) TAF-like (Hiller et al., 2004.9.14) tTAF (Ringrose, 2006)
Name Synonym	golfballs   spermatocyte arrest (Rautureau et al., 2009, Moon et al., 2011, Vibranovski et al., 2009, Gan et al., 2010) spermatocytes arrest (Turk and Hiller, 2006) testis-specific TBP Associated Factor (Ringrose, 2006)
Secondary FlyBase IDs
	FBgn0037080
References ( 55 )
Generate a list of	All references relating to this gene ( 55 )
List References by type	Research paper  ( 27 ) Supplementary material  ( 4 ) Review  ( 4 ) Personal communication to FlyBase  ( 2 ) Abstract  ( 15 ) DNA/RNA sequence record  ( 1 ) Book  ( 1 )
Recent research papers ( 7 )
	Chen et al., 2011, Development 138(12): 2441--2450 Sequential changes at differentiation gene promoters as they become active in a stem cell lineage. [FBrf0213772] Doggett et al., 2011, Dev. Biol. 355(2): 381--393 Wake-up-call, a lin-52 paralogue, and Always early, a lin-9 homologue physically interact, but have opposing functions in regulating testis-specific gene expression. [FBrf0213964] Moon et al., 2011, Development 138(17): 3835--3845 The THO complex is required for nucleolar integrity in Drosophila spermatocytes. [FBrf0214600] Di Cara et al., 2010, Insect Mol. Biol. 19(6): 807--813 Expressional and functional analysis of the male-specific cluster mst36F during Drosophila spermatogenesis. [FBrf0212329] Gan et al., 2010, Cell Res. 20(7): 763--783 Dynamic regulation of alternative splicing and chromatin structure in Drosophila gonads revealed by RNA-seq. [FBrf0211191] Gan et al., 2010, Genome Biol. 11(4): R42 Monovalent and unpoised status of most genes in undifferentiated cell-enriched Drosophila testis. [FBrf0211027] White-Cooper, 2010, Reproduction 139(1): 11--21 Molecular mechanisms of gene regulation during Drosophila spermatogenesis. [FBrf0209523] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2010 Show reviews ...