TAF8L, ms(3)sa, tTAF
Gene model reviewed during 5.40
Gene model reviewed during 5.46
There is only one protein coding transcript and one polypeptide associated with this gene
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\sa using the Feature Mapper tool.
Turns on specifically in male germ cells soon after initiation of spermatocyte differentiation and persists throughout the remainder of the primary spermatocyte stage. Localizes to the nucleolus.
GBrowse - Visual display of RNA-Seq signalsView Dmel\sa in GBrowse 2
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Source for merge of: sa CG11308
Mutant allele fails to complement a QTL affecting male mating behaviour.
Wild type function of aly, can, mia and sa is required for cell-cycle progression through the G2/M transition of meiosis I in males and for onset of spermatid differentiation. Mutations in can and sa are epistatic to mutations in twe. The phenotype of these meiotic arrest mutants is strikingly similar to the histopathological features of meiosis I maturation arrest infertility in human males, suggesting that the control point may be conserved from flies to man.
sa is required for both the progression of the male meiotic cell cycle and the onset of postmeiotic differentiation.