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Gene Dmel\MtnA

General Information
Symbol	Dmel\MtnA	Species	D. melanogaster
Name	Metallothionein A	Annotation symbol	CG9470
Feature type	protein_coding_gene	FlyBase ID	FBgn0002868
Gene Model Status	Current	Stock availability	4 publicly available
Also Known As	MTN
Genomic Location
Chromosome (arm)	3R	Recombination map
Cytogenetic map	85E9-85E9	Sequence location	3R:5,609,487..5,610,093 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Metallothionein A is referred to in FlyBase by the symbol Dmel\MtnA (CG9470, FBgn0002868). It is a protein_coding_gene from Drosophila melanogaster. It is reported to have molecular function: metal ion binding. The biological processes in which it is involved are not known. 18 alleles are reported. The phenotype of these alleles is annotated with: mesothoracic tergum. It has one annotated transcript and one annotated polypeptide. Protein features are: Metallothionein, family 5, Diptera. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of extremely high expression to a trough of low expression. Peak expression observed within 18-24 hour embryonic stages, at stages throughout the larval period, in adult male stages. Summary of FlyAtlas Anatomical Expression Data: Nearly all larval and adult organs/tissues expressed at high levels. Expression at high levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, adult salivary gland, adult spermathecae, adult male reproductive system, larval/adult carcass. Expression at moderate levels in the following post-embryonic organs or tissues: larval trachea, adult ovary. Comments on Affy2 ProbeSet: ProbeSet 1632873_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of MtnA. Gene sequence location is 3R:5609487..5610093.
Phenotypic Description from the Red Book (Lindsley & Zimm 1992)
Gene/Allele symbols may differ from current usage	Mtn: Metallothionein (G. Maroni) Codes for metallothionein, a metal binding protein. Inducible by ingestion of Cu or Cd (but not Zn) ions. In larvae, it is expressed mainly in the midgut. No point mutations are available, but Dp(3;3)Mtn+H22 shows increased tolerance to Cd.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2011_10	References Hua et al., 2011, Biol. Chem. 392(10): 919--926 Alleles MtnA[Scer\UAS.cHa]
FB2012_01	References Zhao et al., 2010, Nucleic Acids Res. 38(Database issue): D710--D715 Atanesyan et al., 2011, J. Biol. Inorg. Chem. 16(7): 1047--1056 Sequence features BKN32833 Transgenic Constructs P{UAS-MtnA.H}
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 85E9-85E9   Limits computationally determined from genome sequence between P{EP}CrcEP3006 and P{lacW}s2681
Experimentally Determined Cytological Location
Cytogenetic map Notes References 85E10-85E15   (determined by in situ hybridisation)   (Ranz et al., 1997) 85E-85E   (determined by in situ hybridisation)   (Whiting et al., 1989) 85E10-85E15   (determined by in situ hybridisation)   (Otto et al., 1986) 85E10-85E15   (determined by in situ hybridisation)   (Maroni et al., 1986) 85E10-85E15   (determined by in situ hybridisation)   (Lastowski-Perry et al., 1985)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\MtnA for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) MtnA-RA FBtr0082158  NM_079575   343   40
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein MtnA-PA   FBpp0081636   3.9   40   7.85     NP_524299   AAF54452
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Metallothionein, family 5, Diptera (IPR000966)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AE014297 AAF54452   AI062995   AI134361   AI135921   AI238973   AI297093   AI297982   AI387801   AI389779   AI402839   AI946278   AX201658   AX201660   AX201665   BE977028   BE977845   BF493196   BF493805   BG632289   BG632574   BG633343   BI239444   BI565729   BI566008   BI570870   BI571170   BI571731   BI571987   BI571998   BI574848   BI583577   BI584270   BI585779   BI586334   BI587391   BI590867   BI590871   BI605880   BI605893   BI607255   BI607261   BI611900   BI613708   BI614424   BI614808   BI615200   BI619560   BI619659   BI620219   BI621944   BI624013   BI627656   BI630670   BI631661   BT001431 AAN71186   BT081369   CA803422   CK135509   CK660026   CK662499   CO152706   CO152827   CO153462   CO153509   CO153569   CO153851   CO153861   CO154812   CO155519   CO155552   CO155830   CO156369   CO156484   CO156521   CO156587   CO178495   CO196013   CO266957   CO268848   CO269698   CO269954   CO284596   CO315982   CO320412   CO329226   CO331093   CO335378   CO335624   CO335954   CO336261   CO337204   CO337390   CO337597   CO337924   CO338311   CO338363   CO338495   CO338535   CO338571   CO338763   EC056671   EC088961   EC090041   EC090162   EC219949   EC226939   EC228013   EC233613   EC236961   EC249785   EC254797   EC260910   EC261107   EC261146   EC261740   EC262159   EC262537   EC262742   EC263058   EC263240   EC263373   EC263381   EC263493   EC263511   EC264055   EC264276   EC264413   EC264501   EC264546   EC264668   EC265218   EC265333   EC265473   EC265482   EC266248   EC266747   EC266776   EC266831   EC267199   EC267418   EC267425   EC267506   EC267605   EC267610   EC267749   EL873749   EL878964   EL878965   EV577598   EV577764   EV578531   EV582457   EV586900   EV590011   EV592420   EV593338   EV593444   EV594559   EV595217   EV596658   EV597643   EV597657   EV598342   EV598938   EV599523   EV600087   GH748557   GH750803   GH752128   GH756099   GH757238   GH757657   GH757673   GH757729   GH760084   GH773847   GH774060   GH777096   GH777443   GH778513   GH778904   GH787121   GH787362   GH787533   GH789073   GH790496   GH791735   GH793135   GH798009   GH798871   GH802220   GH802574   GH803176   GH803415   GH805491   GH808129   GH810583   GH810774   GH810954   GH811661   GH812474   GH814225   GH815275   GH819341   GH819350   GH819489   GH819780   GH820762   GH821108   GH822393   GH822684   GH823615   GH823671   GH825206   GH825337   GH828368   GH829578   GH829966   GH830196   GH830889   GH832996   GH836132   GH838139   GH838652   GH839525   GH841464   GH843385   GH844366   GH847834   GH848298   GH848328   GH850618   GH850859   GH851283   GH852093   GH852869   GH859012   GH859030   GH859181   GH860078   GH860793   GH862450   GH862600   GH863028   GH865745   GH865821   GH865984   GH867392   GH868486   GH869040   GH869155   GH870241   GH870695   GH871359   GH871552   GH871913   GH871931   GH872259   GH872573   GH873008   GH874311   GH874494   GH874520   GH874738   GH882855   GH882866   GH884985   GH885223   GH885451   GH885550   GH886167   GH888350   GH889848   GH890309   GH891643   GH894534   GH894906   GH895506   GH896652   GH899707   GH899861   GH902954   GH903533   GH905045   GH906423   GH906857   GH907298   GH907802   GH913394   GH914215   GH914232   GH914873   GH915129   GH915479   GH915976   GH916627   GH920871   GH920940   GH922037   GH922089   GH922237   GH923880   GH923955   GH927177   GH928877   GH930143   GH930771   GH931449   GH933771   GH933967   GH938909   GH939262   GH939791   GH940076   GH940775   K02314 AAA28681   M13983   M13984   M13985   M27708 AAA28684   M69015 AAB41334   X03758 CAA27391
UniProtKB/Swiss-Prot	P04357
UniProtKB/TrEMBL
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences	EPD - Eukarytoic Promoter Database, an annotated collection of POL II promoters • 11042
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0002868    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0002868 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of extremely high expression to a trough of low expression. Peak expression observed within 18-24 hour embryonic stages, at stages throughout the larval period, in adult male stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0002868 expression level Developmental Stage   Expression Level embryo 00-02hr    482 embryo 02-04hr    258 embryo 04-06hr    233 embryo 06-08hr    571 embryo 08-10hr    2159 embryo 10-12hr    13200 embryo 12-14hr    18162 embryo 14-16hr    36255 embryo 16-18hr    86621 embryo 18-20hr    133987 embryo 20-22hr    196227 embryo 22-24hr    222547 larva L1    214768 larva L2    106261 larva L3 12hr old    121513 larva L3 puffstage 1-2    160521 larva L3 puffstage 3-6    76733 larva L3 puffstage 7-9    58223 white prepupae new    35381 white prepupae 12hr    34583 white prepupae 24hr    39994 pupae 2d postWPP    11756 pupae 3d postWPP    17748 pupae 4d postWPP    14523 adult male 01day    84038 adult male 05day    81213 adult male 30day    183082 adult female 01day    27181 adult female 05day    16293 adult female 30day    37131 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (482) embryo 02-04hr  (258) embryo 04-06hr  (233) embryo 06-08hr  (571) embryo 08-10hr  (2159) embryo 10-12hr  (13200) embryo 12-14hr  (18162) embryo 14-16hr  (36255) embryo 16-18hr  (86621) embryo 18-20hr  (133987) embryo 20-22hr  (196227) embryo 22-24hr  (222547) larva L1  (214768) larva L2  (106261) larva L3 12hr old  (121513) larva L3 puffstage 1-2  (160521) larva L3 puffstage 3-6  (76733) larva L3 puffstage 7-9  (58223) white prepupae new  (35381) white prepupae 12hr  (34583) white prepupae 24hr  (39994) pupae 2d postWPP  (11756) pupae 3d postWPP  (17748) pupae 4d postWPP  (14523) adult male 01day  (84038) adult male 05day  (81213) adult male 30day  (183082) adult female 01day  (27181) adult female 05day  (16293) adult female 30day  (37131) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    482 embryo 02-04hr    258 embryo 04-06hr    233 embryo 06-08hr    571 embryo 08-10hr  (2159) embryo 10-12hr  (13200) embryo 12-14hr  (18162) embryo 14-16hr  (36255) embryo 16-18hr  (86621) embryo 18-20hr  (133987) embryo 20-22hr  (196227) embryo 22-24hr  (222547) larva L1  (214768) larva L2  (106261) larva L3 12hr old  (121513) larva L3 puffstage 1-2  (160521) larva L3 puffstage 3-6  (76733) larva L3 puffstage 7-9  (58223) white prepupae new  (35381) white prepupae 12hr  (34583) white prepupae 24hr  (39994) pupae 2d postWPP  (11756) pupae 3d postWPP  (17748) pupae 4d postWPP  (14523) adult male 01day  (84038) adult male 05day  (81213) adult male 30day  (183082) adult female 01day  (27181) adult female 05day  (16293) adult female 30day  (37131) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    482 embryo 02-04hr    258 embryo 04-06hr    233 embryo 06-08hr    571 embryo 08-10hr    2159 embryo 10-12hr  (13200) embryo 12-14hr  (18162) embryo 14-16hr  (36255) embryo 16-18hr  (86621) embryo 18-20hr  (133987) embryo 20-22hr  (196227) embryo 22-24hr  (222547) larva L1  (214768) larva L2  (106261) larva L3 12hr old  (121513) larva L3 puffstage 1-2  (160521) larva L3 puffstage 3-6  (76733) larva L3 puffstage 7-9  (58223) white prepupae new  (35381) white prepupae 12hr  (34583) white prepupae 24hr  (39994) pupae 2d postWPP  (11756) pupae 3d postWPP  (17748) pupae 4d postWPP  (14523) adult male 01day  (84038) adult male 05day  (81213) adult male 30day  (183082) adult female 01day  (27181) adult female 05day  (16293) adult female 30day  (37131) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    482 embryo 02-04hr    258 embryo 04-06hr    233 embryo 06-08hr    571 embryo 08-10hr    2159 embryo 10-12hr    13200 embryo 12-14hr    18162 embryo 14-16hr    36255 embryo 16-18hr    86621 embryo 18-20hr    133987 embryo 20-22hr    196227 embryo 22-24hr    222547 larva L1    214768 larva L2    106261 larva L3 12hr old    121513 larva L3 puffstage 1-2    160521 larva L3 puffstage 3-6    76733 larva L3 puffstage 7-9    58223 white prepupae new    35381 white prepupae 12hr    34583 white prepupae 24hr    39994 pupae 2d postWPP    11756 pupae 3d postWPP    17748 pupae 4d postWPP    14523 adult male 01day    84038 adult male 05day    81213 adult male 30day    183082 adult female 01day    27181 adult female 05day    16293 adult female 30day    37131 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0002868 expression level Developmental Stage   Expression Level embryo 00-02hr    482 embryo 02-04hr    258 embryo 04-06hr    233 embryo 06-08hr    571 embryo 08-10hr    2159 embryo 10-12hr    13200 embryo 12-14hr    18162 embryo 14-16hr    36255 embryo 16-18hr    86621 embryo 18-20hr    133987 embryo 20-22hr    196227 embryo 22-24hr    222547 larva L1    214768 larva L2    106261 larva L3 12hr old    121513 larva L3 puffstage 1-2    160521 larva L3 puffstage 3-6    76733 larva L3 puffstage 7-9    58223 white prepupae new    35381 white prepupae 12hr    34583 white prepupae 24hr    39994 pupae 2d postWPP    11756 pupae 3d postWPP    17748 pupae 4d postWPP    14523 adult male 01day    84038 adult male 05day    81213 adult male 30day    183082 adult female 01day    27181 adult female 05day    16293 adult female 30day    37131 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (482) embryo 02-04hr  (258) embryo 04-06hr  (233) embryo 06-08hr  (571) embryo 08-10hr  (2159) embryo 10-12hr  (13200) embryo 12-14hr  (18162) embryo 14-16hr  (36255) embryo 16-18hr  (86621) embryo 18-20hr  (133987) embryo 20-22hr  (196227) embryo 22-24hr  (222547) larva L1  (214768) larva L2  (106261) larva L3 12hr old  (121513) larva L3 puffstage 1-2  (160521) larva L3 puffstage 3-6  (76733) larva L3 puffstage 7-9  (58223) white prepupae new  (35381) white prepupae 12hr  (34583) white prepupae 24hr  (39994) pupae 2d postWPP  (11756) pupae 3d postWPP  (17748) pupae 4d postWPP  (14523) adult male 01day  (84038) adult male 05day  (81213) adult male 30day  (183082) adult female 01day  (27181) adult female 05day  (16293) adult female 30day  (37131) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    482 embryo 02-04hr    258 embryo 04-06hr    233 embryo 06-08hr    571 embryo 08-10hr  2159 embryo 10-12hr  (13200) embryo 12-14hr  (18162) embryo 14-16hr  (36255) embryo 16-18hr  (86621) embryo 18-20hr  (133987) embryo 20-22hr  (196227) embryo 22-24hr  (222547) larva L1  (214768) larva L2  (106261) larva L3 12hr old  (121513) larva L3 puffstage 1-2  (160521) larva L3 puffstage 3-6  (76733) larva L3 puffstage 7-9  (58223) white prepupae new  (35381) white prepupae 12hr  (34583) white prepupae 24hr  (39994) pupae 2d postWPP  (11756) pupae 3d postWPP  (17748) pupae 4d postWPP  (14523) adult male 01day  (84038) adult male 05day  (81213) adult male 30day  (183082) adult female 01day  (27181) adult female 05day  (16293) adult female 30day  (37131) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    482 embryo 02-04hr    258 embryo 04-06hr    233 embryo 06-08hr    571 embryo 08-10hr    2159 embryo 10-12hr  13200 embryo 12-14hr  18162 embryo 14-16hr  (36255) embryo 16-18hr  (86621) embryo 18-20hr  (133987) embryo 20-22hr  (196227) embryo 22-24hr  (222547) larva L1  (214768) larva L2  (106261) larva L3 12hr old  (121513) larva L3 puffstage 1-2  (160521) larva L3 puffstage 3-6  (76733) larva L3 puffstage 7-9  (58223) white prepupae new  (35381) white prepupae 12hr  (34583) white prepupae 24hr  (39994) pupae 2d postWPP  11756 pupae 3d postWPP  17748 pupae 4d postWPP  14523 adult male 01day  (84038) adult male 05day  (81213) adult male 30day  (183082) adult female 01day  (27181) adult female 05day  16293 adult female 30day  (37131) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    482 embryo 02-04hr    258 embryo 04-06hr    233 embryo 06-08hr    571 embryo 08-10hr    2159 embryo 10-12hr    13200 embryo 12-14hr    18162 embryo 14-16hr    36255 embryo 16-18hr    86621 embryo 18-20hr    133987 embryo 20-22hr    196227 embryo 22-24hr    222547 larva L1    214768 larva L2    106261 larva L3 12hr old    121513 larva L3 puffstage 1-2    160521 larva L3 puffstage 3-6    76733 larva L3 puffstage 7-9    58223 white prepupae new    35381 white prepupae 12hr    34583 white prepupae 24hr    39994 pupae 2d postWPP    11756 pupae 3d postWPP    17748 pupae 4d postWPP    14523 adult male 01day    84038 adult male 05day    81213 adult male 30day    183082 adult female 01day    27181 adult female 05day    16293 adult female 30day    37131 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0002868    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0002868 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Nearly all larval and adult organs/tissues expressed at high levels. Expression at high levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, adult salivary gland, adult spermathecae, adult male reproductive system, larval/adult carcass. Expression at moderate levels in the following post-embryonic organs or tissues: larval trachea, adult ovary. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0002868 expression level Tissue   Expression Level Larval Central Nervous System    2917.4 Larval Midgut    6261.6 Larval Hindgut    4358.1 Larval Malpighian Tubules    7460.4 Larval Fat Body    1537.2 Larval Salivary Gland    72.2 Larval Trachea    361.275 Larval Carcass    1315.4 Adult Head    4968.6 Adult Eye    5763.075 Adult Brain    4017.7 Adult Thoracic-Abdominal Ganglion    4902.6 Adult Crop    1079.6 Adult Midgut    7424.7 Adult Hindgut    6717.9 Adult Malpighian Tubules    8783 Adult Fat Body    6064 Adult Salivary Gland    10073.9 Adult Heart    8527.95 Adult VirginFemale Spermatheca    5880.4 Adult InseminatedFemale Spermatheca    5883.5 Adult Ovary    494.2 Adult Testis    4030.3 Adult Male Accessory Gland    3195.8 Adult Carcass    8526 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System  (2917.4) Larval Midgut  (6261.6) Larval Hindgut  (4358.1) Larval Malpighian Tubules  (7460.4) Larval Fat Body  (1537.2) Larval Salivary Gland    72.2 Larval Trachea    361.275 Larval Carcass  (1315.4) Adult Head  (4968.6) Adult Eye  (5763.075) Adult Brain  (4017.7) Adult Thoracic-Abdominal Ganglion  (4902.6) Adult Crop  (1079.6) Adult Midgut  (7424.7) Adult Hindgut  (6717.9) Adult Malpighian Tubules  (8783) Adult Fat Body  (6064) Adult Salivary Gland  (10073.9) Adult Heart  (8527.95) Adult VirginFemale Spermatheca  (5880.4) Adult InseminatedFemale Spermatheca  (5883.5) Adult Ovary    494.2 Adult Testis  (4030.3) Adult Male Accessory Gland  (3195.8) Adult Carcass  (8526) Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System  (2917.4) Larval Midgut  (6261.6) Larval Hindgut  (4358.1) Larval Malpighian Tubules  (7460.4) Larval Fat Body  (1537.2) Larval Salivary Gland    72.2 Larval Trachea    361.275 Larval Carcass  (1315.4) Adult Head  (4968.6) Adult Eye  (5763.075) Adult Brain  (4017.7) Adult Thoracic-Abdominal Ganglion  (4902.6) Adult Crop  (1079.6) Adult Midgut  (7424.7) Adult Hindgut  (6717.9) Adult Malpighian Tubules  (8783) Adult Fat Body  (6064) Adult Salivary Gland  (10073.9) Adult Heart  (8527.95) Adult VirginFemale Spermatheca  (5880.4) Adult InseminatedFemale Spermatheca  (5883.5) Adult Ovary    494.2 Adult Testis  (4030.3) Adult Male Accessory Gland  (3195.8) Adult Carcass  (8526) Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    2917.4 Larval Midgut    6261.6 Larval Hindgut    4358.1 Larval Malpighian Tubules    7460.4 Larval Fat Body    1537.2 Larval Salivary Gland    72.2 Larval Trachea    361.275 Larval Carcass    1315.4 Adult Head    4968.6 Adult Eye    5763.075 Adult Brain    4017.7 Adult Thoracic-Abdominal Ganglion    4902.6 Adult Crop    1079.6 Adult Midgut    7424.7 Adult Hindgut    6717.9 Adult Malpighian Tubules    8783 Adult Fat Body    6064 Adult Salivary Gland    10073.9 Adult Heart    8527.95 Adult VirginFemale Spermatheca    5880.4 Adult InseminatedFemale Spermatheca    5883.5 Adult Ovary    494.2 Adult Testis    4030.3 Adult Male Accessory Gland    3195.8 Adult Carcass    8526 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0002868 expression level Tissue   Expression Level Larval Central Nervous System    2917.4 Larval Midgut    6261.6 Larval Hindgut    4358.1 Larval Malpighian Tubules    7460.4 Larval Fat Body    1537.2 Larval Salivary Gland    72.2 Larval Trachea    361.275 Larval Carcass    1315.4 Adult Head    4968.6 Adult Eye    5763.075 Adult Brain    4017.7 Adult Thoracic-Abdominal Ganglion    4902.6 Adult Crop    1079.6 Adult Midgut    7424.7 Adult Hindgut    6717.9 Adult Malpighian Tubules    8783 Adult Fat Body    6064 Adult Salivary Gland    10073.9 Adult Heart    8527.95 Adult VirginFemale Spermatheca    5880.4 Adult InseminatedFemale Spermatheca    5883.5 Adult Ovary    494.2 Adult Testis    4030.3 Adult Male Accessory Gland    3195.8 Adult Carcass    8526 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System  (2917.4) Larval Midgut  (6261.6) Larval Hindgut  (4358.1) Larval Malpighian Tubules  (7460.4) Larval Fat Body  (1537.2) Larval Salivary Gland    72.2 Larval Trachea    361.275 Larval Carcass  (1315.4) Adult Head  (4968.6) Adult Eye  (5763.075) Adult Brain  (4017.7) Adult Thoracic-Abdominal Ganglion  (4902.6) Adult Crop  (1079.6) Adult Midgut  (7424.7) Adult Hindgut  (6717.9) Adult Malpighian Tubules  (8783) Adult Fat Body  (6064) Adult Salivary Gland  (10073.9) Adult Heart  (8527.95) Adult VirginFemale Spermatheca  (5880.4) Adult InseminatedFemale Spermatheca  (5883.5) Adult Ovary    494.2 Adult Testis  (4030.3) Adult Male Accessory Gland  (3195.8) Adult Carcass  (8526) Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System  (2917.4) Larval Midgut  (6261.6) Larval Hindgut  (4358.1) Larval Malpighian Tubules  (7460.4) Larval Fat Body  1537.2 Larval Salivary Gland    72.2 Larval Trachea    361.275 Larval Carcass  1315.4 Adult Head  (4968.6) Adult Eye  (5763.075) Adult Brain  (4017.7) Adult Thoracic-Abdominal Ganglion  (4902.6) Adult Crop  1079.6 Adult Midgut  (7424.7) Adult Hindgut  (6717.9) Adult Malpighian Tubules  (8783) Adult Fat Body  (6064) Adult Salivary Gland  (10073.9) Adult Heart  (8527.95) Adult VirginFemale Spermatheca  (5880.4) Adult InseminatedFemale Spermatheca  (5883.5) Adult Ovary    494.2 Adult Testis  (4030.3) Adult Male Accessory Gland  (3195.8) Adult Carcass  (8526) Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    2917.4 Larval Midgut    6261.6 Larval Hindgut    4358.1 Larval Malpighian Tubules    7460.4 Larval Fat Body    1537.2 Larval Salivary Gland    72.2 Larval Trachea    361.275 Larval Carcass    1315.4 Adult Head    4968.6 Adult Eye    5763.075 Adult Brain    4017.7 Adult Thoracic-Abdominal Ganglion    4902.6 Adult Crop    1079.6 Adult Midgut    7424.7 Adult Hindgut    6717.9 Adult Malpighian Tubules    8783 Adult Fat Body    6064 Adult Salivary Gland    10073.9 Adult Heart    8527.95 Adult VirginFemale Spermatheca    5880.4 Adult InseminatedFemale Spermatheca    5883.5 Adult Ovary    494.2 Adult Testis    4030.3 Adult Male Accessory Gland    3195.8 Adult Carcass    8526 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    4968.6   NA  Eye    5763.075   NA  Brain    4017.7   2917.4  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    4902.6   NA  Crop    1079.6   6261.6  Midgut    7424.7   4358.1  Hindgut    6717.9   7460.4  Malpighian Tubules    8783   1537.2  Fat Body    6064   72.2  Salivary Gland    10073.9   NA  Heart    8527.95   361.275  Trachea    NA   NA  VirginFemale Spermatheca    5880.4   NA  InseminatedFemale Spermatheca    5883.5   NA  Ovary    494.2   NA  Testis    4030.3   NA  Male Accessory Gland    3195.8   1315.4  Carcass    8526 modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_18
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0002868 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG9470-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele viable, with Scer\GAL4pnr-MD237 MtnAGD13735 MtnAGD15524 Other Phenotypes Allele body color defective, with Scer\GAL4pnr-MD237 MtnAGD13735 chemical sensitive MtnAΔATG visible, with Scer\GAL4pnr-MD237 MtnAGD13735 MtnAGD15524 Phenotype manifest in Allele chaeta | supernumerary, with Scer\GAL4pnr-MD237 MtnAGD13735 mesothoracic tergum, with Scer\GAL4pnr-MD237 MtnAGD13735 trichogen cell | supernumerary, with Scer\GAL4pnr-MD237 MtnAGD15524
Classical Alleles ( 5 )
For All Classical Alleles Show
Allele of MtnA Class Mutagen Stocks Known lesion MtnA1 natural population 0 -- MtnA1Dp natural population 0 Yes MtnA3 natural population 0 Yes MtnAK45 0 Yes MtnAΔATG FLPase recombination SCEI endonuclease I-CreI endonuclease 0 Yes
Alleles Carried on Transgenic Constructs ( 13 )
For All Alleles Carried on Transgenic Constructs Show
Allele of MtnA Class Mutagen Stocks Known lesion MtnAGD15524 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes MtnAGD13735 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes MtnAKK112833 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes MtnA+54.T:Mdom\L1 in vitro construct 0 Yes MtnA+tEa in vitro construct - genomic fragment 0 Yes MtnA-373.T:Mdom\L1 in vitro construct 0 Yes MtnA-373 in vitro construct 0 Yes MtnA-3900.T:Mdom\L1 in vitro construct 0 Yes MtnA3.tMa in vitro construct - genomic fragment 0 Yes MtnAMTW in vitro construct - genomic fragment 0 Yes MtnAScer\UAS.cEa in vitro construct - regulatory fusion 0 Yes MtnAScer\UAS.cHa in vitro construct - regulatory fusion 0 Yes MtnAΔATG.Scer\SceI.RS in vitro construct 0 Yes
Aneuploid Aberrations
Disrupted in	Df(3R)by10 (Maroni et al., 1986)
Not disrupted in	Df(3R)GB104 (Maroni et al., 1986)
Duplicated in	Dp(3;3)Mtn+H22 (Otto et al., 1986)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data reporter construct P{MtnA.Pn-Adh} No P{TATAlacZ} No UAS construct P{GD13735} NA P{GD15524} NA P{KK112833} NA P{UAS-MtnA.E} NA P{UAS-MtnA.H} NA characterization construct P{-373MtnL1ry+} NA P{-373Mtnry+} NA P{-3900MtnL1ry+} NA P{(FRT.w3xP3.MtnAΔATG.Scer\SceI.RS)} NA P{+54MtnL1ry+} NA P{MtnA3.M} NA P{MtnA+tEa} NA P{MTW} NA
Insertions
	Type of insertions Name Expression data
Gene Ontology: Function, Process & Cellular Component ( 1 unique term )
Terms Based on Experimental Evidence ( 0 terms )
Terms Based on Predictions or Assertions ( 1 term )
Molecular Function
CV term Evidence References
metal ion binding inferred from electronic annotation with InterPro:IPR000966 (FlyBase Curators et al., 2004-) non-traceable author statement (FlyBase, 1992-, Swiss-Prot Project Members, 1987.3.20)
Biological Process ( 0 terms)
Cellular Component ( 0 terms)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions MtnA allele Gene References unspecified Ctr1B (Egli et al., 2006)
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 66359 DroID - A comprehensive database of gene and protein interactions. • FBgn0002868 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 41202
Orthologs
Genome-wide drosophilid orthologs	Dana\MtnA Dere\MtnA Dmoj\MtnA Dper\MtnA Dpse\MtnA Dsec\MtnA Dsim\MtnA Dvir\MtnA Dwil\MtnA Dyak\MtnA
Curated drosophilid orthologs	Dana\MtnA   Dbuz\MtnA   Dere\MtnA   Dmau\MtnA   Dpse\MtnA   Drep\MtnA   Dsec\MtnA   Dsim\MtnA   Dtei\MtnA   Dyak\MtnA
Linkouts	OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • FBgn0241833 FBgn0213133 FBgn0211602 FBgn0012845 FBgn0181066 FBgn0081797 FBgn0160819 FBgn0147600 FBgn0109552 FBgn0013782 ACYPI29981 AGAP006524 GLEAN_12239
Stocks & Reagents
Stocks Listed in FlyBase ( 4 )
VDRC	v105011 P{KK112833}VIE-260B v46119 w1118; P{GD15524}v46119 v46120 w1118; P{GD15524}v46120 v23697 w1118; P{GD13735}v23697/TM3
Genomic Clones ( 2 )
	BACR23O04 BACR30F01 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 309 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	GH18460
Other clones	MIP09177
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	GH02392 GH06260 GH10839 GH11806 GH13843 GH15131 GH21039 GH22145 GH24932 LP11294 LP12477 LP18244 LP22763 RE35929 RH04552 RH04556 RH05656 RH05995 RH07015 RH07320 RH07332 RH18358 RH22226 RH23330 RH25435 RH26260 RH27090 RH28056 RH35090 RH42928 RH43787 RH44281 RH44773 RH50620 RH50636 RH50736 RH51304 RH53736 RH56386 RH59953 RH61282 RH63543 RH69023 RH71883 RH71902 RH74277 RH74284
Other clones	36997 104226 148697 160435 162694 179078 190033 194701 214275.41 473567 473693 522051 522431 522491 522564 522876 522889 524030 524056 524148 524952 524984 525618 527777 527865 527971 528007 533816 533913 542559 542890 557001 557161 568842 569053 569125 569280 571263 571315 572730 572770 572805 572945 AT01505 AT02161 bs22h08 bs59a06 bs69h06 CK01.111A.H3 CK01.121C.G12 Dmel_dig_008134_0614_0561 Dmel_dig_010097_0666_1858 Dmel_dig_013065_0587_2356 Dmel_dig_017317_0645_3148 Dmel_neb_006861_0572_1769 Dmel_neb_008510_0911_2282 Dmel_neb_008551_0867_0274 Dmel_neb_009984_0142_1374 Dmel_neb_010076_0577_3191 Dmel_neb_010437_0578_0558 Dmel_neb_010961_0347_0686 Dmel_neb_011888_0878_1094 Dmel_neb_012593_0892_2405 Dmel_neb_012635_0837_2084 Dmel_neb_013714_0687_0778 Dmel_neb_013809_0665_1325 Dmel_neb_016175_0894_1252 Dmel_neb_016323_0956_1222 EK000130 EK056906 EK092860 EK095605 EK097003 EK148028 EK166357 EK263257 EK284761 EK292313 EK298011 EN00241 EN00535 EN02021 EN02135 EN02351 EN02940 EN02956 EN04843 EN06237 EN06314 EN06822 EN07930 EN08147 EN08227 EN08344 EN10224 EN10845 EN11544 EN12152 EN14033 EN14439 EN14863 EN15609 EN16451 EN16614 EN16938 EN17031 EN17116 EN17547 ESG011d.E7.1_H09 IP08839 IP13841 RP003016882 RP003017570 RP003020836 RP003021499 RP003029223 RP003034144 RP003045368 RP003062543 RP003065067 RP003065999 RP003089866 RP003092976 RP003095811 RP003099670 RP003102493 RP003107874 RP003111534 RP003118564 RP003119115 RP003120218 RP003120463 RP003123078 RP003123521 RP003126370 RP003129060 RP003130851 RP003130918 RP003133444 RP003147794 RP003153187 RP003156848 RP003161650 RP003167216 RP003175321 RP003207578 RP003207927 RP003209196 RP003210226 RP003210652 RP003215417 RP003215773 RP003215885 RP003218384 RP003219692 RP003220614 RP003222252 RP003228572 RP003230688 RP003233927 RP003235510 RP003236553 RP003239602 RP003240795 RP003241943 RP003242075 RP003242584 RP003247133 RP003250028 RP003254759 RP003256523 RP003256819 RP003258779 RP003264594 RP003265017 RP003265957 RP003266687 RP003268233 RP003270343 RP003275798 RP003276126 RP003276801 RP003285188 RP003289338 RP003291507 RP003292844 RP003293038 RP003294522 RP003298938 RP003302295 RP003305698 RP003306622 RP003315864 RP003320869 RP003321448 RP003321756 RP003323715 RP003327173 RP003330942 RP003332027 RP003334256 RP003341586 RP003347504 RP003348144 RP003351856 RP003353271 RP003356912 RP003392298 RP003406538 RP003419353 RP003428564 RP003433149 RP003434377 RP003436129 RP003453087 RP003455129 RP003463323 RP003464968 RP003469833 RP003475318 RP003477801 RP003481788 RP003489267 RP003489586 RP003494682 RP003495168 RP003497508 RP003497629 RP003502266 RP003507161 RP003508461 RP003517930 RP003523822 RP003539995 RP003548894 RP003550207 RP003569172 RP003572073 RP003584761 RP003585249 RP003590329 RP003604415 RP003604680 RP003608880 RP003614401 RP003615350 RP003626001 RP003629806 RP003635523 RP003636636 RP003643281 RP003645295 RP003646425 RP003653300 RP003657631 RP003668417 RP003669088 RP003669676 RP003671676 RP003678367
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0002868 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 41202
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of	Source for merge of: MtnA anon-WO0153538.42 anon-WO0153538.44 anon-WO0153538.49 (FlyBase, 1996-) Source for merge of: MtnA BcDNA:GH18460 (FlyBase, 1996-)
Additional comments	Source for merge of MtnA anon-WO0153538.42 anon-WO0153538.44 anon-WO0153538.49 was sequence comparison (date:051113). (FlyBase, 1996-) Source for merge of MtnA BcDNA:GH18460 was a shared cDNA (date:030728). (FlyBase, 1996-)
Other Comments
	In a sample of 79 genes with multiple introns, 33 showed significant heterogeneity in G+C content among introns of the same gene and significant positive correspondence between the intron and the third codon position G+C content within genes. These results are consistent with selection adding against preferred codons at the start of genes. (Kliman and Eyre-Walker, 1998) MtnA promoter expression induced by CuSO4 in recombinant baculovirus is inducible but 'leaky'. (Lanier et al., 1997) Codes for metallothionein, a metal binding protein. Inducible by ingestion of Cu or Cd (but not Zn) ions. In larvae, it is expressed mainly in the midgut. No point mutations are available, but Dp(3;3)Mtn+H22 shows increased tolerance to Cd. (Lindsley and Zimm, 1992) MtnA and MtnB gene structure and expression pattern have been compared. (Silar et al., 1990) Metal-regulated and tissue-specific expression of MtnA requires no more than 373bp upstream of the transcription start site. MtnA sequences from -130 to -6bp are sufficient to confer metal-regulated expression to MtnA-Hsim\TK promoter fusion constructs. (Otto et al., 1987)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_079575 RefSeq (Proteins) • NP_524299 DDBJ / EMBL / GenBank • AAA28681 AAA28684 AAB41334 AAF54452 AAN71186 AI135921 AI387801 AI946278 AX201658 AX201660 AX201665 BT001431 CAA27391 K02314 M13983 M13984 M13985 M27708 M69015 X03758 Entrez Gene - A searchable database of RefSeq genes. • 41202 UniProtKB/Swiss-Prot • P04357
Other Crossreferences
	EPD - Eukarytoic Promoter Database, an annotated collection of POL II promoters • 11042 InterPro domains - A database of protein families, domains, and functional sites • Metallothionein, family 5, Diptera (IPR000966)
Linkouts
	BioGRID - A database of protein and genetic interactions • 66359 DroID - A comprehensive database of gene and protein interactions. • FBgn0002868 DRSC - Results from RNAi screens. • FBgn0002868 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0002868 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG9470-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0002868 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 41202 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 41202 modMine - Data generated by the modENCODE project. • FBgn0002868 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • FBgn0241833 FBgn0213133 FBgn0211602 FBgn0012845 FBgn0181066 FBgn0081797 FBgn0160819 FBgn0147600 FBgn0109552 FBgn0013782 ACYPI29981 AGAP006524 GLEAN_12239
Synonyms & Secondary IDs ( 13 )
Reported As
Symbol Synonym	anon-WO0153538.42   anon-WO0153538.44   anon-WO0153538.49   BcDNA:GH18460   CG9470 (Sun et al., 2010, Keleman et al., 2009.8.5) DrosMtn (Dallinger, 1996) MTN (Domenech et al., 2003, Valls et al., 2000, Grushko et al., 1998) Mtn (Theodore, 1991.11.5, Wu and Fallon, 1997, Netter et al., 1998, Lanier et al., 1997, Bonneton et al., 1996, Aguade and Langley, 1994, Maroni et al., 1995, Rasmussen and Lis, 1995, Bonneton and Wegnez, 1995, Crandall and Templeton, 1993, Wiehe and Stephan, 1993, Angelichio et al., 1991, Theodore et al., 1991, Silar et al., 1990, Silar and Wegnez, 1990, Zhang et al., 2001) MtnA (Wang et al., 2004, Marr et al., 2006, Egli et al., 2006, Gruenewald et al., 2009, Egli et al., 2006, Balamurugan et al., 2004, Sun et al., 2010, Yepiskoposyan et al., 2006, Isogai et al., 2007, Balamurugan et al., 2007, Chen et al., 2008, Tio et al., 2009, Southon et al., 2008, Wang et al., 2009, Spresser et al., 2008, Capdevila et al., 2010, Kohn et al., 2008, Nagoshi et al., 2010, Pospisilik et al., 2010, Boyd et al., 2011, Guirola et al., 2011, Parisi et al., 2004, Hua et al., 2011, Zhao et al., 2010, Atanesyan et al., 2011)
Name Synonym	metallothionein (Cherbas and Cherbas, 1993, Southon et al., 2008) Metallothionein A   metallothionein A (Marr et al., 2006, Balamurugan et al., 2007, Boyd et al., 2011, Hua et al., 2011) metallothionein N (McVean and Vieira, 2001)
Secondary FlyBase IDs
	FBgn0045904 FBgn0045909 FBgn0045911 FBgn0064964
References ( 101 )
Generate a list of	All references relating to this gene ( 101 )
List References by type	Research paper  ( 71 ) Supplementary material  ( 4 ) Review  ( 5 ) Personal communication to FlyBase  ( 4 ) Abstract  ( 6 ) FlyBase analysis  ( 2 ) DNA/RNA sequence record  ( 1 ) Letter  ( 1 ) Book  ( 1 ) Protein sequence record  ( 1 ) Computer file  ( 1 ) Thesis  ( 1 ) Automatic genome annotation  ( 1 ) Patent  ( 1 ) Curated genome annotation  ( 1 )
Recent research papers ( 9 )
	Atanesyan et al., 2011, J. Biol. Inorg. Chem. 16(7): 1047--1056 Characterization of MtnE, the fifth metallothionein member in Drosophila. [FBrf0215591] Boyd et al., 2011, Free Radical Biol. Med. 50(11): 1669--1678 Nectarine promotes longevity in Drosophila melanogaster. [FBrf0213612] Guirola et al., 2011, J. Inorg. Biochem. 105(8): 1050--1059 Comparative genomics analysis of metallothioneins in twelve Drosophila species. [FBrf0214507] Hua et al., 2011, Biol. Chem. 392(10): 919--926 Toxicity of Alzheimer's disease-associated Aβ peptide is ameliorated in a Drosophila model by tight control of zinc and copper availability. [FBrf0215055] Capdevila et al., 2010, Bioinorg. Chem. Appl.: 541829 The zn- or cu-thionein character of a metallothionein determines its metal load when synthesized in physiological (metal-unsupplemented) conditions. [FBrf0210775] Nagoshi et al., 2010, Nat. Neurosci. 13(1): 60--68 Dissecting differential gene expression within the circadian neuronal circuit of Drosophila. [FBrf0209632] Pospisilik et al., 2010, Cell 140(1): 148--160 Drosophila genome-wide obesity screen reveals hedgehog as a determinant of brown versus white adipose cell fate. [FBrf0212676] Sun et al., 2010, Exp. Gerontol. 45(3): 243--251 Açai palm fruit (Euterpe oleracea Mart.) pulp improves survival of flies on a high fat diet. [FBrf0210041] Zhao et al., 2010, Nucleic Acids Res. 38(Database issue): D710--D715 FlyTED: the Drosophila Testis Gene Expression Database. [FBrf0209626] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2010 Show reviews ...