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Gene Dmel\mu2

General Information
Symbol	Dmel\mu2	Species	D. melanogaster
Name	mutator 2	Annotation symbol	CG1960
Feature type	protein_coding_gene	FlyBase ID	FBgn0002872
Gene Model Status	Current	Stock availability	13 publicly available
Genomic Location
Chromosome (arm)	3L	Recombination map
Cytogenetic map	62B11-62B11	Sequence location	3L:1,942,734..1,947,475 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene mutator 2 is referred to in FlyBase by the symbol Dmel\mu2 (CG1960, FBgn0002872). It is a protein_coding_gene from Drosophila melanogaster. Its molecular function is unknown. There is experimental evidence that it is involved in the biological process: double-strand break repair. 13 alleles are reported. The phenotypes of these alleles are annotated with: trichogen cell; mesothoracic tergum. It has 3 annotated transcripts and 3 annotated polypeptides. Protein features are: BRCT domain. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of low expression. Peak expression observed within 00-12 hour embryonic stages, in adult female stages. Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: larval central nervous system, adult ovary. Comments on Affy2 ProbeSet: ProbeSet 1638979_a_at completely aligns to an exonic region common to each of the 3 FlyBase-annotated transcript isoforms of mu2. Gene sequence location is 3L:1942734..1947475.
User Contributed Data
	Beta version, feedback welcome
Phenotypic Description from the Red Book (Lindsley & Zimm 1992)
Gene/Allele symbols may differ from current usage	mu2 Irradiation of females homozygous for mu2 with low doses of X rays produces substantial numbers of terminal deficiencies for all chromosome arms, [see for example Df(1)yT]; irradiation of heterozygous females produces frequencies of deficiencies intermediate between those obtained from homozygous mu2 and wild-type females. Extents of deficiencies limited only by the ability to recover them in viable offspring. Incidence of terminal losses linear with dose; such deficiencies visible cytologically and can be shown by in situ hybridization to lack sequences characteristically present at the termini of chromosome arms. Irradiation of mu2 females does not increase the incidence of either interstitial deficiencies or sex-linked lethal mutations. Irradiation of mu2 males does not increase the frequency of deficiencies.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 62B11-62B11   Limits computationally determined from genome sequence between P{PZ}dlt04276 and P{PZ}slsrL182
Experimentally Determined Cytological Location
Cytogenetic map Notes References 63B11-63C1     (Kasravi, 1999.5.4) 62B11-62C1     (Kasravi, 1998.11.19) 62B12-62C1   (determined by in situ hybridisation)   (Wang and Mason, 1992)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\mu2 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.46 Low-frequency RNA-Seq exon junction(s) not annotated.
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) mu2-RA FBtr0072856  NM_079163   4117   1280 mu2-RB FBtr0072857  NM_167927   4054   1259 mu2-RC FBtr0301465  NM_001169855   4099   1274
Additional Transcript Data & Comments
Reported size (kB)	4.0 (northern blot) (Kasravi et al., 1999)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein mu2-PA   FBpp0072735   140.6   1280   6.54     NP_523887   AAF47597 mu2-PB   FBpp0072736   138.3   1259   6.90     NP_728695   AAN11507 mu2-PC   FBpp0290680   139.8   1274   6.62     NP_001163326   ACZ94598
Additional Polypeptide Data & Comments
Reported size (kDa)	1261 (aa); 139 (kD predicted) (Kasravi et al., 1999)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • BRCT domain (IPR001357)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA391156   AA391527   AA735664   AA817405   AE014296 AAF47597   AE014296 AAN11507   AE014296 ACZ94598   AF108206 AAC83937   AF148494 AAD35085   AI237925   AI239114   AI402381   AI455606   AI456847   AI512334   AI512916   AI519608   AW943700   AY061475 AAL29023   BG637930   BG638050   BG638944   BI163359   BI354140   BI605649   BI605658   BI610775   BI612485   BI616641   BI621576   BT030128   CK661060   CO189527   CO295958   CO325237   CZ467975   CZ478163   CZ479614   CZ479615   CZ484116   EC086371   EC195348   EL871912   EL875248
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q95RC8 Q9W061 A2VEF9 O96685
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference adult stage | femaleoogenesis stage S5 -- oogenesis stage S6   oocyte | posterior   (Kasravi et al., 1999) northern blot Stage Tissue/Position (including subcellular localization) Reference embryonic stage   presumptive embryonic/larval central nervous system   (Kasravi et al., 1999) embryonic stage | early   organism | ubiquitous   (Kasravi et al., 1999) embryonic stage -- adult stage     (Kasravi et al., 1999) larval stage   eye disc   (Kasravi et al., 1999) imaginal disc   (Kasravi et al., 1999) embryonic/larval brain   (Kasravi et al., 1999) morphogenetic furrow   (Kasravi et al., 1999) adult stage & oogenesis   oocyte   (Kasravi et al., 1999) germarium   (Kasravi et al., 1999) adult stageoogenesis stage S8 -- S14   oocyte | anterior   (Kasravi et al., 1999)
Additional Descriptive Data
	mu2 transcripts are detected at all stages on northern blots with the highest levels in adults and somewhat lower levels in embryos and pupae. In situ hybridization reveals strong expression during oogenesis. Transcripts are first detected in the germarium in one cell of the oocysts which may be the oocyte. At stages S5 to S6, transcripts become transiently more concentrated at the posterior end of the oocyte. After stage S8-S9, they accumulate at the anterior end of the oocyte where they form a ring-shaped pattern. mu2 transcripts are also observed in larval somatic cells especially in proliferating tissues. Expression is increased in proliferating zones in the brain and the morphogenetic furrow of the eye disc. In embryos, mu2 transcripts are ubiquitous at early stages. In later stages, they are expressed in the proliferating nervous system. (Kasravi et al., 1999)
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: larval central nervous system, adult ovary. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    177.55 Larval Midgut    14.9 Larval Hindgut    24.6 Larval Malpighian Tubules    15.7 Larval Fat Body    20.2 Larval Salivary Gland    28.2 Larval Trachea    80.975 Larval Carcass    33.975 Adult Head    17.3 Adult Eye    16.45 Adult Brain    53.1 Adult Thoracic-Abdominal Ganglion    43.2 Adult Crop    14.7 Adult Midgut    14 Adult Hindgut    11.9 Adult Malpighian Tubules    14.9 Adult Fat Body    14.3 Adult Salivary Gland    4.1 Adult Heart    13.8 Adult VirginFemale Spermatheca    14 Adult InseminatedFemale Spermatheca    17.8 Adult Ovary    224.9 Adult Testis    58.6 Adult Male Accessory Gland    11.5 Adult Carcass    13.1 Expression Level Scale  None   Low   Moderate  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    177.55 Larval Midgut    14.9 Larval Hindgut    24.6 Larval Malpighian Tubules    15.7 Larval Fat Body    20.2 Larval Salivary Gland    28.2 Larval Trachea    80.975 Larval Carcass    33.975 Adult Head    17.3 Adult Eye    16.45 Adult Brain    53.1 Adult Thoracic-Abdominal Ganglion    43.2 Adult Crop    14.7 Adult Midgut    14 Adult Hindgut    11.9 Adult Malpighian Tubules    14.9 Adult Fat Body    14.3 Adult Salivary Gland    4.1 Adult Heart    13.8 Adult VirginFemale Spermatheca    14 Adult InseminatedFemale Spermatheca    17.8 Adult Ovary    224.9 Adult Testis    58.6 Adult Male Accessory Gland    11.5 Adult Carcass    13.1 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    177.55 Larval Midgut    14.9 Larval Hindgut    24.6 Larval Malpighian Tubules    15.7 Larval Fat Body    20.2 Larval Salivary Gland    28.2 Larval Trachea    80.975 Larval Carcass    33.975 Adult Head    17.3 Adult Eye    16.45 Adult Brain    53.1 Adult Thoracic-Abdominal Ganglion    43.2 Adult Crop    14.7 Adult Midgut    14 Adult Hindgut    11.9 Adult Malpighian Tubules    14.9 Adult Fat Body    14.3 Adult Salivary Gland    4.1 Adult Heart    13.8 Adult VirginFemale Spermatheca    14 Adult InseminatedFemale Spermatheca    17.8 Adult Ovary    224.9 Adult Testis    58.6 Adult Male Accessory Gland    11.5 Adult Carcass    13.1 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    177.55 Larval Midgut    14.9 Larval Hindgut    24.6 Larval Malpighian Tubules    15.7 Larval Fat Body    20.2 Larval Salivary Gland    28.2 Larval Trachea    80.975 Larval Carcass    33.975 Adult Head    17.3 Adult Eye    16.45 Adult Brain    53.1 Adult Thoracic-Abdominal Ganglion    43.2 Adult Crop    14.7 Adult Midgut    14 Adult Hindgut    11.9 Adult Malpighian Tubules    14.9 Adult Fat Body    14.3 Adult Salivary Gland    4.1 Adult Heart    13.8 Adult VirginFemale Spermatheca    14 Adult InseminatedFemale Spermatheca    17.8 Adult Ovary    224.9 Adult Testis    58.6 Adult Male Accessory Gland    11.5 Adult Carcass    13.1 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    177.55 Larval Midgut    14.9 Larval Hindgut    24.6 Larval Malpighian Tubules    15.7 Larval Fat Body    20.2 Larval Salivary Gland    28.2 Larval Trachea    80.975 Larval Carcass    33.975 Adult Head    17.3 Adult Eye    16.45 Adult Brain    53.1 Adult Thoracic-Abdominal Ganglion    43.2 Adult Crop    14.7 Adult Midgut    14 Adult Hindgut    11.9 Adult Malpighian Tubules    14.9 Adult Fat Body    14.3 Adult Salivary Gland    4.1 Adult Heart    13.8 Adult VirginFemale Spermatheca    14 Adult InseminatedFemale Spermatheca    17.8 Adult Ovary    224.9 Adult Testis    58.6 Adult Male Accessory Gland    11.5 Adult Carcass    13.1 Expression Level Scale  None   Low   Moderate  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    177.55 Larval Midgut    14.9 Larval Hindgut    24.6 Larval Malpighian Tubules    15.7 Larval Fat Body    20.2 Larval Salivary Gland    28.2 Larval Trachea    80.975 Larval Carcass    33.975 Adult Head    17.3 Adult Eye    16.45 Adult Brain    53.1 Adult Thoracic-Abdominal Ganglion    43.2 Adult Crop    14.7 Adult Midgut    14 Adult Hindgut    11.9 Adult Malpighian Tubules    14.9 Adult Fat Body    14.3 Adult Salivary Gland    4.1 Adult Heart    13.8 Adult VirginFemale Spermatheca    14 Adult InseminatedFemale Spermatheca    17.8 Adult Ovary    224.9 Adult Testis    58.6 Adult Male Accessory Gland    11.5 Adult Carcass    13.1 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    177.55 Larval Midgut    14.9 Larval Hindgut    24.6 Larval Malpighian Tubules    15.7 Larval Fat Body    20.2 Larval Salivary Gland    28.2 Larval Trachea    80.975 Larval Carcass    33.975 Adult Head    17.3 Adult Eye    16.45 Adult Brain    53.1 Adult Thoracic-Abdominal Ganglion    43.2 Adult Crop    14.7 Adult Midgut    14 Adult Hindgut    11.9 Adult Malpighian Tubules    14.9 Adult Fat Body    14.3 Adult Salivary Gland    4.1 Adult Heart    13.8 Adult VirginFemale Spermatheca    14 Adult InseminatedFemale Spermatheca    17.8 Adult Ovary    224.9 Adult Testis    58.6 Adult Male Accessory Gland    11.5 Adult Carcass    13.1 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    177.55 Larval Midgut    14.9 Larval Hindgut    24.6 Larval Malpighian Tubules    15.7 Larval Fat Body    20.2 Larval Salivary Gland    28.2 Larval Trachea    80.975 Larval Carcass    33.975 Adult Head    17.3 Adult Eye    16.45 Adult Brain    53.1 Adult Thoracic-Abdominal Ganglion    43.2 Adult Crop    14.7 Adult Midgut    14 Adult Hindgut    11.9 Adult Malpighian Tubules    14.9 Adult Fat Body    14.3 Adult Salivary Gland    4.1 Adult Heart    13.8 Adult VirginFemale Spermatheca    14 Adult InseminatedFemale Spermatheca    17.8 Adult Ovary    224.9 Adult Testis    58.6 Adult Male Accessory Gland    11.5 Adult Carcass    13.1 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    17.3   NA  Eye    16.45   NA  Brain    53.1   177.55  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    43.2   NA  Crop    no informative data   no informative data  Midgut    no informative data   24.6  Hindgut    no informative data   no informative data  Malpighian Tubules    no informative data   no informative data  Fat Body    14.3   28.2  Salivary Gland    4.1   NA  Heart    13.8   80.975  Trachea    NA   NA  VirginFemale Spermatheca    no informative data   NA  InseminatedFemale Spermatheca    17.8   NA  Ovary    224.9   NA  Testis    58.6   NA  Male Accessory Gland    no informative data   33.975  Carcass    no informative data FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    17 central nervous system, larvae L3    14 central nervous system, pupae P8    6 head, virgin 1-day female    2 head, virgin 4-day female    1 head, virgin 20-day female    1 head, mated 1-day female    3 head, mated 4-day female    1 head, mated 20-day female    1 head, mated 1-day male    3 head, mated 4-day male    2 head, mated 20-day male    3 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    2 digestive system, 1-day adult    1 digestive system, 4-day adult    2 digestive system, 20-day adult    2 fat body, larvae L3 wandering    1 fat body, white prepupae    4 fat body, pupae P8    0 carcass, larvae L3 wandering    7 carcass, 1-day adult    2 carcass, 4-day adult    3 carcass, 20-day adult    2 ovary, virgin 4-day female    54 ovary, mated 4-day female    55 testis, mated 4-day male    8 accessory gland, mated 4-day male    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    17 central nervous system, larvae L3    14 central nervous system, pupae P8    6 head, virgin 1-day female    2 head, virgin 4-day female    1 head, virgin 20-day female    1 head, mated 1-day female    3 head, mated 4-day female    1 head, mated 20-day female    1 head, mated 1-day male    3 head, mated 4-day male    2 head, mated 20-day male    3 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    2 digestive system, 1-day adult    1 digestive system, 4-day adult    2 digestive system, 20-day adult    2 fat body, larvae L3 wandering    1 fat body, white prepupae    4 fat body, pupae P8    0 carcass, larvae L3 wandering    7 carcass, 1-day adult    2 carcass, 4-day adult    3 carcass, 20-day adult    2 ovary, virgin 4-day female  (54) ovary, mated 4-day female  (55) testis, mated 4-day male    8 accessory gland, mated 4-day male    2 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    17 central nervous system, larvae L3    14 central nervous system, pupae P8    6 head, virgin 1-day female    2 head, virgin 4-day female    1 head, virgin 20-day female    1 head, mated 1-day female    3 head, mated 4-day female    1 head, mated 20-day female    1 head, mated 1-day male    3 head, mated 4-day male    2 head, mated 20-day male    3 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    2 digestive system, 1-day adult    1 digestive system, 4-day adult    2 digestive system, 20-day adult    2 fat body, larvae L3 wandering    1 fat body, white prepupae    4 fat body, pupae P8    0 carcass, larvae L3 wandering    7 carcass, 1-day adult    2 carcass, 4-day adult    3 carcass, 20-day adult    2 ovary, virgin 4-day female    54 ovary, mated 4-day female    55 testis, mated 4-day male    8 accessory gland, mated 4-day male    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    17 central nervous system, larvae L3    14 central nervous system, pupae P8    6 head, virgin 1-day female    2 head, virgin 4-day female    1 head, virgin 20-day female    1 head, mated 1-day female    3 head, mated 4-day female    1 head, mated 20-day female    1 head, mated 1-day male    3 head, mated 4-day male    2 head, mated 20-day male    3 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    2 digestive system, 1-day adult    1 digestive system, 4-day adult    2 digestive system, 20-day adult    2 fat body, larvae L3 wandering    1 fat body, white prepupae    4 fat body, pupae P8    0 carcass, larvae L3 wandering    7 carcass, 1-day adult    2 carcass, 4-day adult    3 carcass, 20-day adult    2 ovary, virgin 4-day female    54 ovary, mated 4-day female    55 testis, mated 4-day male    8 accessory gland, mated 4-day male    2 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    17 central nervous system, larvae L3    14 central nervous system, pupae P8    6 head, virgin 1-day female    2 head, virgin 4-day female    1 head, virgin 20-day female    1 head, mated 1-day female    3 head, mated 4-day female    1 head, mated 20-day female    1 head, mated 1-day male    3 head, mated 4-day male    2 head, mated 20-day male    3 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    2 digestive system, 1-day adult    1 digestive system, 4-day adult    2 digestive system, 20-day adult    2 fat body, larvae L3 wandering    1 fat body, white prepupae    4 fat body, pupae P8    0 carcass, larvae L3 wandering    7 carcass, 1-day adult    2 carcass, 4-day adult    3 carcass, 20-day adult    2 ovary, virgin 4-day female    54 ovary, mated 4-day female    55 testis, mated 4-day male    8 accessory gland, mated 4-day male    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    17 central nervous system, larvae L3    14 central nervous system, pupae P8    6 head, virgin 1-day female    2 head, virgin 4-day female    1 head, virgin 20-day female    1 head, mated 1-day female    3 head, mated 4-day female    1 head, mated 20-day female    1 head, mated 1-day male    3 head, mated 4-day male    2 head, mated 20-day male    3 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    2 digestive system, 1-day adult    1 digestive system, 4-day adult    2 digestive system, 20-day adult    2 fat body, larvae L3 wandering    1 fat body, white prepupae    4 fat body, pupae P8    0 carcass, larvae L3 wandering    7 carcass, 1-day adult    2 carcass, 4-day adult    3 carcass, 20-day adult    2 ovary, virgin 4-day female  (54) ovary, mated 4-day female  (55) testis, mated 4-day male    8 accessory gland, mated 4-day male    2 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    17 central nervous system, larvae L3    14 central nervous system, pupae P8    6 head, virgin 1-day female    2 head, virgin 4-day female    1 head, virgin 20-day female    1 head, mated 1-day female    3 head, mated 4-day female    1 head, mated 20-day female    1 head, mated 1-day male    3 head, mated 4-day male    2 head, mated 20-day male    3 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    2 digestive system, 1-day adult    1 digestive system, 4-day adult    2 digestive system, 20-day adult    2 fat body, larvae L3 wandering    1 fat body, white prepupae    4 fat body, pupae P8    0 carcass, larvae L3 wandering    7 carcass, 1-day adult    2 carcass, 4-day adult    3 carcass, 20-day adult    2 ovary, virgin 4-day female    54 ovary, mated 4-day female    55 testis, mated 4-day male    8 accessory gland, mated 4-day male    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    17 central nervous system, larvae L3    14 central nervous system, pupae P8    6 head, virgin 1-day female    2 head, virgin 4-day female    1 head, virgin 20-day female    1 head, mated 1-day female    3 head, mated 4-day female    1 head, mated 20-day female    1 head, mated 1-day male    3 head, mated 4-day male    2 head, mated 20-day male    3 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    2 digestive system, 1-day adult    1 digestive system, 4-day adult    2 digestive system, 20-day adult    2 fat body, larvae L3 wandering    1 fat body, white prepupae    4 fat body, pupae P8    0 carcass, larvae L3 wandering    7 carcass, 1-day adult    2 carcass, 4-day adult    3 carcass, 20-day adult    2 ovary, virgin 4-day female    54 ovary, mated 4-day female    55 testis, mated 4-day male    8 accessory gland, mated 4-day male    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of low expression. Peak expression observed within 00-12 hour embryonic stages, in adult female stages. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    31 embryo 02-04hr    32 embryo 04-06hr    30 embryo 06-08hr    25 embryo 08-10hr    20 embryo 10-12hr    7 embryo 12-14hr    8 embryo 14-16hr    7 embryo 16-18hr    5 embryo 18-20hr    3 embryo 20-22hr    7 embryo 22-24hr    7 larva L1    2 larva L2    2 larva L3 12hr old    2 larva L3 puffstage 1-2    3 larva L3 puffstage 3-6    4 larva L3 puffstage 7-9    5 white prepupae new    5 white prepupae 12hr    8 white prepupae 24hr    6 pupae 2d postWPP    4 pupae 3d postWPP    2 pupae 4d postWPP    2 adult male 01day    2 adult male 05day    3 adult male 30day    3 adult female 01day    12 adult female 05day    24 adult female 30day    24 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (31) embryo 02-04hr  (32) embryo 04-06hr  (30) embryo 06-08hr    25 embryo 08-10hr    20 embryo 10-12hr    7 embryo 12-14hr    8 embryo 14-16hr    7 embryo 16-18hr    5 embryo 18-20hr    3 embryo 20-22hr    7 embryo 22-24hr    7 larva L1    2 larva L2    2 larva L3 12hr old    2 larva L3 puffstage 1-2    3 larva L3 puffstage 3-6    4 larva L3 puffstage 7-9    5 white prepupae new    5 white prepupae 12hr    8 white prepupae 24hr    6 pupae 2d postWPP    4 pupae 3d postWPP    2 pupae 4d postWPP    2 adult male 01day    2 adult male 05day    3 adult male 30day    3 adult female 01day    12 adult female 05day    24 adult female 30day    24 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    31 embryo 02-04hr    32 embryo 04-06hr    30 embryo 06-08hr    25 embryo 08-10hr    20 embryo 10-12hr    7 embryo 12-14hr    8 embryo 14-16hr    7 embryo 16-18hr    5 embryo 18-20hr    3 embryo 20-22hr    7 embryo 22-24hr    7 larva L1    2 larva L2    2 larva L3 12hr old    2 larva L3 puffstage 1-2    3 larva L3 puffstage 3-6    4 larva L3 puffstage 7-9    5 white prepupae new    5 white prepupae 12hr    8 white prepupae 24hr    6 pupae 2d postWPP    4 pupae 3d postWPP    2 pupae 4d postWPP    2 adult male 01day    2 adult male 05day    3 adult male 30day    3 adult female 01day    12 adult female 05day    24 adult female 30day    24 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    31 embryo 02-04hr    32 embryo 04-06hr    30 embryo 06-08hr    25 embryo 08-10hr    20 embryo 10-12hr    7 embryo 12-14hr    8 embryo 14-16hr    7 embryo 16-18hr    5 embryo 18-20hr    3 embryo 20-22hr    7 embryo 22-24hr    7 larva L1    2 larva L2    2 larva L3 12hr old    2 larva L3 puffstage 1-2    3 larva L3 puffstage 3-6    4 larva L3 puffstage 7-9    5 white prepupae new    5 white prepupae 12hr    8 white prepupae 24hr    6 pupae 2d postWPP    4 pupae 3d postWPP    2 pupae 4d postWPP    2 adult male 01day    2 adult male 05day    3 adult male 30day    3 adult female 01day    12 adult female 05day    24 adult female 30day    24 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    31 embryo 02-04hr    32 embryo 04-06hr    30 embryo 06-08hr    25 embryo 08-10hr    20 embryo 10-12hr    7 embryo 12-14hr    8 embryo 14-16hr    7 embryo 16-18hr    5 embryo 18-20hr    3 embryo 20-22hr    7 embryo 22-24hr    7 larva L1    2 larva L2    2 larva L3 12hr old    2 larva L3 puffstage 1-2    3 larva L3 puffstage 3-6    4 larva L3 puffstage 7-9    5 white prepupae new    5 white prepupae 12hr    8 white prepupae 24hr    6 pupae 2d postWPP    4 pupae 3d postWPP    2 pupae 4d postWPP    2 adult male 01day    2 adult male 05day    3 adult male 30day    3 adult female 01day    12 adult female 05day    24 adult female 30day    24 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  31 embryo 02-04hr  32 embryo 04-06hr  30 embryo 06-08hr    25 embryo 08-10hr    20 embryo 10-12hr    7 embryo 12-14hr    8 embryo 14-16hr    7 embryo 16-18hr    5 embryo 18-20hr    3 embryo 20-22hr    7 embryo 22-24hr    7 larva L1    2 larva L2    2 larva L3 12hr old    2 larva L3 puffstage 1-2    3 larva L3 puffstage 3-6    4 larva L3 puffstage 7-9    5 white prepupae new    5 white prepupae 12hr    8 white prepupae 24hr    6 pupae 2d postWPP    4 pupae 3d postWPP    2 pupae 4d postWPP    2 adult male 01day    2 adult male 05day    3 adult male 30day    3 adult female 01day    12 adult female 05day    24 adult female 30day    24 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    31 embryo 02-04hr    32 embryo 04-06hr    30 embryo 06-08hr    25 embryo 08-10hr    20 embryo 10-12hr    7 embryo 12-14hr    8 embryo 14-16hr    7 embryo 16-18hr    5 embryo 18-20hr    3 embryo 20-22hr    7 embryo 22-24hr    7 larva L1    2 larva L2    2 larva L3 12hr old    2 larva L3 puffstage 1-2    3 larva L3 puffstage 3-6    4 larva L3 puffstage 7-9    5 white prepupae new    5 white prepupae 12hr    8 white prepupae 24hr    6 pupae 2d postWPP    4 pupae 3d postWPP    2 pupae 4d postWPP    2 adult male 01day    2 adult male 05day    3 adult male 30day    3 adult female 01day    12 adult female 05day    24 adult female 30day    24 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    31 embryo 02-04hr    32 embryo 04-06hr    30 embryo 06-08hr    25 embryo 08-10hr    20 embryo 10-12hr    7 embryo 12-14hr    8 embryo 14-16hr    7 embryo 16-18hr    5 embryo 18-20hr    3 embryo 20-22hr    7 embryo 22-24hr    7 larva L1    2 larva L2    2 larva L3 12hr old    2 larva L3 puffstage 1-2    3 larva L3 puffstage 3-6    4 larva L3 puffstage 7-9    5 white prepupae new    5 white prepupae 12hr    8 white prepupae 24hr    6 pupae 2d postWPP    4 pupae 3d postWPP    2 pupae 4d postWPP    2 adult male 01day    2 adult male 05day    3 adult male 30day    3 adult female 01day    12 adult female 05day    24 adult female 30day    24 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    27 Schneider line 2 Sg4    5 embryonic 1182-4H    10 embryonic GM2    22 embryonic Kc167    10 embryonic S1    24 embryonic S3    15 leg disc CME L1    7 wing disc CME-W2    9 wing disc ML-DmD8    15 wing disc ML-DmD9    12 wing disc ML-DmD16-c3    15 wing disc ML-DmD21    3 wing disc ML-DmD32    6 haltere disc ML-DmD17-c3    19 eye-antennal disc ML-DmD11    10 antennal disc ML-DmD20-c5    13 mixed discs ML-DmD4-c1    9 CNS ML-DmBG1-c1    18 CNS ML-DmBG2-c2    19 tumorous blood cells mbn2    6 ovary fGS/OSS    22 ovary OSC    13 ovary OSS    7 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (27) Schneider line 2 Sg4    5 embryonic 1182-4H    10 embryonic GM2    22 embryonic Kc167    10 embryonic S1    24 embryonic S3    15 leg disc CME L1    7 wing disc CME-W2    9 wing disc ML-DmD8    15 wing disc ML-DmD9    12 wing disc ML-DmD16-c3    15 wing disc ML-DmD21    3 wing disc ML-DmD32    6 haltere disc ML-DmD17-c3    19 eye-antennal disc ML-DmD11    10 antennal disc ML-DmD20-c5    13 mixed discs ML-DmD4-c1    9 CNS ML-DmBG1-c1    18 CNS ML-DmBG2-c2    19 tumorous blood cells mbn2    6 ovary fGS/OSS    22 ovary OSC    13 ovary OSS    7 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    27 Schneider line 2 Sg4    5 embryonic 1182-4H    10 embryonic GM2    22 embryonic Kc167    10 embryonic S1    24 embryonic S3    15 leg disc CME L1    7 wing disc CME-W2    9 wing disc ML-DmD8    15 wing disc ML-DmD9    12 wing disc ML-DmD16-c3    15 wing disc ML-DmD21    3 wing disc ML-DmD32    6 haltere disc ML-DmD17-c3    19 eye-antennal disc ML-DmD11    10 antennal disc ML-DmD20-c5    13 mixed discs ML-DmD4-c1    9 CNS ML-DmBG1-c1    18 CNS ML-DmBG2-c2    19 tumorous blood cells mbn2    6 ovary fGS/OSS    22 ovary OSC    13 ovary OSS    7 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    27 Schneider line 2 Sg4    5 embryonic 1182-4H    10 embryonic GM2    22 embryonic Kc167    10 embryonic S1    24 embryonic S3    15 leg disc CME L1    7 wing disc CME-W2    9 wing disc ML-DmD8    15 wing disc ML-DmD9    12 wing disc ML-DmD16-c3    15 wing disc ML-DmD21    3 wing disc ML-DmD32    6 haltere disc ML-DmD17-c3    19 eye-antennal disc ML-DmD11    10 antennal disc ML-DmD20-c5    13 mixed discs ML-DmD4-c1    9 CNS ML-DmBG1-c1    18 CNS ML-DmBG2-c2    19 tumorous blood cells mbn2    6 ovary fGS/OSS    22 ovary OSC    13 ovary OSS    7 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    27 Schneider line 2 Sg4    5 embryonic 1182-4H    10 embryonic GM2    22 embryonic Kc167    10 embryonic S1    24 embryonic S3    15 leg disc CME L1    7 wing disc CME-W2    9 wing disc ML-DmD8    15 wing disc ML-DmD9    12 wing disc ML-DmD16-c3    15 wing disc ML-DmD21    3 wing disc ML-DmD32    6 haltere disc ML-DmD17-c3    19 eye-antennal disc ML-DmD11    10 antennal disc ML-DmD20-c5    13 mixed discs ML-DmD4-c1    9 CNS ML-DmBG1-c1    18 CNS ML-DmBG2-c2    19 tumorous blood cells mbn2    6 ovary fGS/OSS    22 ovary OSC    13 ovary OSS    7 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  27 Schneider line 2 Sg4    5 embryonic 1182-4H    10 embryonic GM2    22 embryonic Kc167    10 embryonic S1    24 embryonic S3    15 leg disc CME L1    7 wing disc CME-W2    9 wing disc ML-DmD8    15 wing disc ML-DmD9    12 wing disc ML-DmD16-c3    15 wing disc ML-DmD21    3 wing disc ML-DmD32    6 haltere disc ML-DmD17-c3    19 eye-antennal disc ML-DmD11    10 antennal disc ML-DmD20-c5    13 mixed discs ML-DmD4-c1    9 CNS ML-DmBG1-c1    18 CNS ML-DmBG2-c2    19 tumorous blood cells mbn2    6 ovary fGS/OSS    22 ovary OSC    13 ovary OSS    7 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    27 Schneider line 2 Sg4    5 embryonic 1182-4H    10 embryonic GM2    22 embryonic Kc167    10 embryonic S1    24 embryonic S3    15 leg disc CME L1    7 wing disc CME-W2    9 wing disc ML-DmD8    15 wing disc ML-DmD9    12 wing disc ML-DmD16-c3    15 wing disc ML-DmD21    3 wing disc ML-DmD32    6 haltere disc ML-DmD17-c3    19 eye-antennal disc ML-DmD11    10 antennal disc ML-DmD20-c5    13 mixed discs ML-DmD4-c1    9 CNS ML-DmBG1-c1    18 CNS ML-DmBG2-c2    19 tumorous blood cells mbn2    6 ovary fGS/OSS    22 ovary OSC    13 ovary OSS    7 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    27 Schneider line 2 Sg4    5 embryonic 1182-4H    10 embryonic GM2    22 embryonic Kc167    10 embryonic S1    24 embryonic S3    15 leg disc CME L1    7 wing disc CME-W2    9 wing disc ML-DmD8    15 wing disc ML-DmD9    12 wing disc ML-DmD16-c3    15 wing disc ML-DmD21    3 wing disc ML-DmD32    6 haltere disc ML-DmD17-c3    19 eye-antennal disc ML-DmD11    10 antennal disc ML-DmD20-c5    13 mixed discs ML-DmD4-c1    9 CNS ML-DmBG1-c1    18 CNS ML-DmBG2-c2    19 tumorous blood cells mbn2    6 ovary fGS/OSS    22 ovary OSC    13 ovary OSS    7 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    8 cold shock, 4-day adult    6 heat shock, 4-day adult    12 Cadmium 50 mM 6 hrs, larvae L3    3 Cadmium 50 mM 12 hrs, larvae L3    3 Cadmium 50 mM 48 hrs, 4-day adult    13 Cadmium 100 mM 48 hrs, 4-day adult    33 Copper 0.5 mM 12 hrs, larvae L3    1 Copper 15 mM 48 hrs, 4-day adult    22 Zinc 5 mM 12 hrs, larvae L3    2 Zinc 4.5 mM 48 hrs, 4-day adult    11 Ethanol 2.5% 3 hrs, larvae L3    24 Ethanol 5% 3 hrs, larvae L3    3 Ethanol 10% 3 hrs, larvae L3    2 Caffeine 1.5 mg/ml 4 hrs, larvae L3    3 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    32 Caffeine 25 mg/ml 48 hrs, 4-day adult    10 Paraquat 5 mM 48 hrs, 4-day adult    23 Paraquat 10 mM 48 hrs, 4-day adult    19 Rotenone 2 μg 12 hrs, larvae L3    2 Rotenone 8 μg 12 hrs, larvae L3    1 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    8 cold shock, 4-day adult    6 heat shock, 4-day adult    12 Cadmium 50 mM 6 hrs, larvae L3    3 Cadmium 50 mM 12 hrs, larvae L3    3 Cadmium 50 mM 48 hrs, 4-day adult    13 Cadmium 100 mM 48 hrs, 4-day adult  (33) Copper 0.5 mM 12 hrs, larvae L3    1 Copper 15 mM 48 hrs, 4-day adult    22 Zinc 5 mM 12 hrs, larvae L3    2 Zinc 4.5 mM 48 hrs, 4-day adult    11 Ethanol 2.5% 3 hrs, larvae L3    24 Ethanol 5% 3 hrs, larvae L3    3 Ethanol 10% 3 hrs, larvae L3    2 Caffeine 1.5 mg/ml 4 hrs, larvae L3    3 Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (32) Caffeine 25 mg/ml 48 hrs, 4-day adult    10 Paraquat 5 mM 48 hrs, 4-day adult    23 Paraquat 10 mM 48 hrs, 4-day adult    19 Rotenone 2 μg 12 hrs, larvae L3    2 Rotenone 8 μg 12 hrs, larvae L3    1 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    8 cold shock, 4-day adult    6 heat shock, 4-day adult    12 Cadmium 50 mM 6 hrs, larvae L3    3 Cadmium 50 mM 12 hrs, larvae L3    3 Cadmium 50 mM 48 hrs, 4-day adult    13 Cadmium 100 mM 48 hrs, 4-day adult    33 Copper 0.5 mM 12 hrs, larvae L3    1 Copper 15 mM 48 hrs, 4-day adult    22 Zinc 5 mM 12 hrs, larvae L3    2 Zinc 4.5 mM 48 hrs, 4-day adult    11 Ethanol 2.5% 3 hrs, larvae L3    24 Ethanol 5% 3 hrs, larvae L3    3 Ethanol 10% 3 hrs, larvae L3    2 Caffeine 1.5 mg/ml 4 hrs, larvae L3    3 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    32 Caffeine 25 mg/ml 48 hrs, 4-day adult    10 Paraquat 5 mM 48 hrs, 4-day adult    23 Paraquat 10 mM 48 hrs, 4-day adult    19 Rotenone 2 μg 12 hrs, larvae L3    2 Rotenone 8 μg 12 hrs, larvae L3    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    8 cold shock, 4-day adult    6 heat shock, 4-day adult    12 Cadmium 50 mM 6 hrs, larvae L3    3 Cadmium 50 mM 12 hrs, larvae L3    3 Cadmium 50 mM 48 hrs, 4-day adult    13 Cadmium 100 mM 48 hrs, 4-day adult    33 Copper 0.5 mM 12 hrs, larvae L3    1 Copper 15 mM 48 hrs, 4-day adult    22 Zinc 5 mM 12 hrs, larvae L3    2 Zinc 4.5 mM 48 hrs, 4-day adult    11 Ethanol 2.5% 3 hrs, larvae L3    24 Ethanol 5% 3 hrs, larvae L3    3 Ethanol 10% 3 hrs, larvae L3    2 Caffeine 1.5 mg/ml 4 hrs, larvae L3    3 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    32 Caffeine 25 mg/ml 48 hrs, 4-day adult    10 Paraquat 5 mM 48 hrs, 4-day adult    23 Paraquat 10 mM 48 hrs, 4-day adult    19 Rotenone 2 μg 12 hrs, larvae L3    2 Rotenone 8 μg 12 hrs, larvae L3    1 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    8 cold shock, 4-day adult    6 heat shock, 4-day adult    12 Cadmium 50 mM 6 hrs, larvae L3    3 Cadmium 50 mM 12 hrs, larvae L3    3 Cadmium 50 mM 48 hrs, 4-day adult    13 Cadmium 100 mM 48 hrs, 4-day adult    33 Copper 0.5 mM 12 hrs, larvae L3    1 Copper 15 mM 48 hrs, 4-day adult    22 Zinc 5 mM 12 hrs, larvae L3    2 Zinc 4.5 mM 48 hrs, 4-day adult    11 Ethanol 2.5% 3 hrs, larvae L3    24 Ethanol 5% 3 hrs, larvae L3    3 Ethanol 10% 3 hrs, larvae L3    2 Caffeine 1.5 mg/ml 4 hrs, larvae L3    3 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    32 Caffeine 25 mg/ml 48 hrs, 4-day adult    10 Paraquat 5 mM 48 hrs, 4-day adult    23 Paraquat 10 mM 48 hrs, 4-day adult    19 Rotenone 2 μg 12 hrs, larvae L3    2 Rotenone 8 μg 12 hrs, larvae L3    1 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    8 cold shock, 4-day adult    6 heat shock, 4-day adult    12 Cadmium 50 mM 6 hrs, larvae L3    3 Cadmium 50 mM 12 hrs, larvae L3    3 Cadmium 50 mM 48 hrs, 4-day adult    13 Cadmium 100 mM 48 hrs, 4-day adult  (33) Copper 0.5 mM 12 hrs, larvae L3    1 Copper 15 mM 48 hrs, 4-day adult    22 Zinc 5 mM 12 hrs, larvae L3    2 Zinc 4.5 mM 48 hrs, 4-day adult    11 Ethanol 2.5% 3 hrs, larvae L3    24 Ethanol 5% 3 hrs, larvae L3    3 Ethanol 10% 3 hrs, larvae L3    2 Caffeine 1.5 mg/ml 4 hrs, larvae L3    3 Caffeine 2.5 mg/ml 48 hrs, 4-day adult  32 Caffeine 25 mg/ml 48 hrs, 4-day adult    10 Paraquat 5 mM 48 hrs, 4-day adult    23 Paraquat 10 mM 48 hrs, 4-day adult    19 Rotenone 2 μg 12 hrs, larvae L3    2 Rotenone 8 μg 12 hrs, larvae L3    1 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    8 cold shock, 4-day adult    6 heat shock, 4-day adult    12 Cadmium 50 mM 6 hrs, larvae L3    3 Cadmium 50 mM 12 hrs, larvae L3    3 Cadmium 50 mM 48 hrs, 4-day adult    13 Cadmium 100 mM 48 hrs, 4-day adult    33 Copper 0.5 mM 12 hrs, larvae L3    1 Copper 15 mM 48 hrs, 4-day adult    22 Zinc 5 mM 12 hrs, larvae L3    2 Zinc 4.5 mM 48 hrs, 4-day adult    11 Ethanol 2.5% 3 hrs, larvae L3    24 Ethanol 5% 3 hrs, larvae L3    3 Ethanol 10% 3 hrs, larvae L3    2 Caffeine 1.5 mg/ml 4 hrs, larvae L3    3 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    32 Caffeine 25 mg/ml 48 hrs, 4-day adult    10 Paraquat 5 mM 48 hrs, 4-day adult    23 Paraquat 10 mM 48 hrs, 4-day adult    19 Rotenone 2 μg 12 hrs, larvae L3    2 Rotenone 8 μg 12 hrs, larvae L3    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    8 cold shock, 4-day adult    6 heat shock, 4-day adult    12 Cadmium 50 mM 6 hrs, larvae L3    3 Cadmium 50 mM 12 hrs, larvae L3    3 Cadmium 50 mM 48 hrs, 4-day adult    13 Cadmium 100 mM 48 hrs, 4-day adult    33 Copper 0.5 mM 12 hrs, larvae L3    1 Copper 15 mM 48 hrs, 4-day adult    22 Zinc 5 mM 12 hrs, larvae L3    2 Zinc 4.5 mM 48 hrs, 4-day adult    11 Ethanol 2.5% 3 hrs, larvae L3    24 Ethanol 5% 3 hrs, larvae L3    3 Ethanol 10% 3 hrs, larvae L3    2 Caffeine 1.5 mg/ml 4 hrs, larvae L3    3 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    32 Caffeine 25 mg/ml 48 hrs, 4-day adult    10 Paraquat 5 mM 48 hrs, 4-day adult    23 Paraquat 10 mM 48 hrs, 4-day adult    19 Rotenone 2 μg 12 hrs, larvae L3    2 Rotenone 8 μg 12 hrs, larvae L3    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010, Graveley et al., 2011) mE2_34_mRNA_expression_cluster_17 mE1_20_mRNA_expression_cluster_06
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0002872 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG1960-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele viable mu2PL00250 viable, with Scer\GAL4pnr-MD237 mu2GD12728 Sterility Allele fertile mu2PL00250 Other Phenotypes Allele body color defective, with Scer\GAL4pnr-MD237 mu2GD12728 visible, with Scer\GAL4pnr-MD237 mu2GD12728 wild-type mu2+t8.5 mu2+t10.3 Phenotype manifest in Allele mesothoracic tergum, with Scer\GAL4pnr-MD237 mu2GD12728 trichogen cell, with Scer\GAL4pnr-MD237 mu2GD12728
Classical Alleles ( 8 )
For All Classical Alleles Show
Allele of mu2 Class Mutagen Stocks Known lesion mu21 spontaneous 4 -- mu2c02474 piggyBac transposase 1 -- mu2c 1 -- mu2e00267 piggyBac transposase 1 -- mu2f01648 piggyBac transposase 1 -- mu2PL00250 P-element activity 1 -- mu2b 0 -- mu2e01793 piggyBac transposase 0 --
Alleles Carried on Transgenic Constructs ( 5 )
For All Alleles Carried on Transgenic Constructs Show
Allele of mu2 Class Mutagen Stocks Known lesion mu2GD12728 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes mu2+t10.3 in vitro construct - genomic fragment 1 Yes mu2Scer\UAS.T:Avic\GFP-EGFP in vitro construct - regulatory fusion in vitro construct - coding region fusion 1 Yes mu2+t8.5 in vitro construct - genomic fragment 0 Yes mu2tA6c in vitro construct - genomic fragment 0 Yes
Aneuploid Aberrations
Disrupted in	Df(3L)Aprt-1 (Wang et al., 1994) Df(3L)Aprt-3 (Wang et al., 1994) Df(3L)Aprt-9 (Wang et al., 1994) Df(3L)Aprt-10 (Wang et al., 1994) Df(3L)Aprt-12 (Wang et al., 1994) Df(3L)Aprt-13 (Wang et al., 1994) Df(3L)Aprt-14 (Wang et al., 1994) Df(3L)Aprt-16 (Wang et al., 1994) Df(3L)Aprt-19 (Wang et al., 1994) Df(3L)Aprt-24 (Machado and Andrew, 2000, Wang et al., 1994) Df(3L)Aprt-26 (Wang et al., 1994) Df(3L)Aprt-27 (Wang et al., 1994) Df(3L)Aprt-29 (Wang et al., 1994) Df(3L)Aprt-31 (Wang et al., 1994) Df(3L)Aprt-32 (Wang et al., 1994) Df(3L)Aprt-36 (Wang et al., 1994) Df(3L)Aprt-42 (Wang et al., 1994) Df(3L)Aprt-46 (Wang et al., 1994) Df(3L)Aprt-47 (Wang et al., 1994) Df(3L)Aprt-54 (Wang et al., 1994) Df(3L)Aprt-61 (Wang et al., 1994) Df(3L)Aprt-65 (Wang et al., 1994) Df(3L)Aprt-71 (Wang et al., 1994) Df(3L)Aprt-72 (Wang et al., 1994) Df(3L)Aprt-73 (Wang et al., 1994) Df(3L)Aprt-74 (Wang et al., 1994) Df(3L)Aprt-79 (Wang et al., 1994) Df(3L)Aprt-87 (Wang et al., 1994) Df(3L)Aprt-88 (Wang et al., 1994) Df(3L)Aprt-91 (Wang et al., 1994) Df(3L)Aprt-92 (Wang et al., 1994) Df(3L)Aprt-93 (Wang et al., 1994) Df(3L)Aprt-95 (Wang et al., 1994) Df(3L)Aprt-96 (Wang et al., 1994) Df(3L)Aprt-98 (Wang et al., 1994) Df(3L)Aprt-99 (Wang et al., 1994) Df(3L)Aprt-100 (Wang et al., 1994) Df(3L)Aprt-102 (Wang et al., 1994) Df(3L)Aprt-103 (Wang et al., 1994) Df(3L)Aprt-104 (Kasravi et al., 1999, Wang et al., 1994) Df(3L)Aprt-105 (Wang et al., 1994) Df(3L)Aprt-106 (Wang et al., 1994) Df(3L)Aprt-107 (Wang et al., 1994) Df(3L)Aprt-108 (Wang et al., 1994) Df(3L)Aprt-109 (Wang et al., 1994) Df(3L)Aprt-110 (Wang et al., 1994) Df(3L)Aprt-111 (Wang et al., 1994) Df(3L)Aprt-112 (Wang et al., 1994) Df(3L)Aprt-113 (Wang et al., 1994) Df(3L)Aprt-114 (Wang et al., 1994) Df(3L)Aprt-117 (Wang et al., 1994) Df(3L)Aprt-118 (Wang et al., 1994) Df(3L)Aprt-119 (Wang et al., 1994) Df(3L)Aprt-120 (Wang et al., 1994) Df(3L)Aprt-122 (Wang et al., 1994) Df(3L)Aprt-123 (Machado and Andrew, 2000, Wang et al., 1994) Df(3L)Aprt-124 (Wang et al., 1994) Df(3L)Aprt-128 (Wang et al., 1994) Df(3L)Aprt-130 (Wang et al., 1994) Df(3L)Aprt-131 (Wang et al., 1994) Df(3L)Aprt-132 (Wang et al., 1994) Df(3L)Aprt-133 (Wang et al., 1994) Df(3L)Aprt-134 (Wang et al., 1994) Df(3L)Aprt-135 (Wang et al., 1994) Df(3L)Aprt-137 (Wang et al., 1994) Df(3L)Aprt-138 (Wang et al., 1994) Df(3L)Aprt-140 (Wang et al., 1994) Df(3L)Aprt-141 (Wang et al., 1994) Df(3L)Aprt-142 (Wang et al., 1994) Df(3L)Aprt-143 (Machado and Andrew, 2000, Wang et al., 1994) Df(3L)Aprt-144 (Wang et al., 1994) Df(3L)Aprt-146 (Wang et al., 1994) Df(3L)Aprt-148 (Wang et al., 1994) Df(3L)Aprt-151 (Wang et al., 1994) Df(3L)Aprt-152 (Wang et al., 1994) Df(3L)Aprt-153 (Wang et al., 1994) Df(3L)Aprt-156 (Wang et al., 1994) Df(3L)Aprt-159 (Wang et al., 1994) Df(3L)Aprt-161 (Wang et al., 1994) Df(3L)Aprt-162 (Wang et al., 1994) Df(3L)Aprt-163 (Wang et al., 1994) Df(3L)Aprt-164 (Wang et al., 1994) Df(3L)Aprt-165 (Wang et al., 1994) Df(3L)Aprt-166 (Wang et al., 1994) Df(3L)Aprt-167 (Wang et al., 1994) Df(3L)Aprt-169 (Wang et al., 1994) Df(3L)Aprt-170 (Wang et al., 1994) Df(3L)Aprt-172 (Wang et al., 1994) Df(3L)Aprt-173 (Wang et al., 1994) Df(3L)Aprt-174 (Wang et al., 1994) Df(3L)Aprt-175 (Wang et al., 1994) Df(3L)Aprt-176 (Wang et al., 1994) Df(3L)Aprt-177 (Wang et al., 1994) Df(3L)Aprt-178 (Wang et al., 1994) Df(3L)Aprt-179 (Wang et al., 1994) Df(3L)Aprt-181 (Wang et al., 1994) Df(3L)Aprt-184 (Wang et al., 1994) Df(3L)Aprt-186 (Wang et al., 1994) Df(3L)Aprt-187 (Wang et al., 1994) Df(3L)Aprt-189 (Wang et al., 1994) Df(3L)Aprt-191 (Wang et al., 1994) Df(3L)Aprt-192 (Wang et al., 1994) Df(3L)Aprt-193 (Wang et al., 1994) Df(3L)Aprt-194 (Wang et al., 1994) Df(3L)Aprt-195 (Wang et al., 1994) Df(3L)Aprt-198 (Kasravi et al., 1999, Wang et al., 1994) Df(3L)Aprt-199 (Wang et al., 1994) Df(3L)Aprt-201 (Wang et al., 1994) Df(3L)R-G5 (Wang et al., 1994) Df(3L)R-G7 (Wang et al., 1994) Ts(2Rt;3Rt)Aprt-185 (Wang et al., 1994)
Not disrupted in	Df(3L)Aprt-15 (Wang et al., 1994) Df(3L)Aprt-18 (Machado and Andrew, 2000, Wang et al., 1994) Df(3L)Aprt-21 (Wang et al., 1994) Df(3L)Aprt-48 (Wang et al., 1994) Df(3L)Aprt-53 (Wang et al., 1994) Df(3L)Aprt-56 (Wang et al., 1994) Df(3L)Aprt-57 (Wang et al., 1994) Df(3L)Aprt-66 (Kasravi et al., 1999, Wang et al., 1994) Df(3L)Aprt-77 (Kasravi et al., 1999, Wang et al., 1994) Df(3L)Aprt-84 (Wang et al., 1994) Df(3L)Aprt-89 (Wang et al., 1994) Df(3L)Aprt-90 (Wang et al., 1994) Df(3L)Aprt-94 (Wang et al., 1994) Df(3L)Aprt-97 (Wang et al., 1994) Df(3L)Aprt-101 (Wang et al., 1994) Df(3L)Aprt-115 (Wang et al., 1994) Df(3L)Aprt-116 (Wang et al., 1994) Df(3L)Aprt-121 (Wang et al., 1994) Df(3L)Aprt-125 (Wang et al., 1994) Df(3L)Aprt-126 (Machado and Andrew, 2000, Wang et al., 1994) Df(3L)Aprt-127 (Wang et al., 1994) Df(3L)Aprt-129 (Wang et al., 1994) Df(3L)Aprt-136 (Wang et al., 1994) Df(3L)Aprt-139 (Wang et al., 1994) Df(3L)Aprt-145 (Wang et al., 1994) Df(3L)Aprt-147 (Wang et al., 1994) Df(3L)Aprt-149 (Wang et al., 1994) Df(3L)Aprt-150 (Wang et al., 1994) Df(3L)Aprt-154 (Wang et al., 1994) Df(3L)Aprt-157 (Wang et al., 1994) Df(3L)Aprt-158 (Wang et al., 1994) Df(3L)Aprt-160 (Wang et al., 1994) Df(3L)Aprt-168 (Wang et al., 1994) Df(3L)Aprt-171 (Wang et al., 1994) Df(3L)Aprt-180 (Wang et al., 1994) Df(3L)Aprt-182 (Wang et al., 1994) Df(3L)Aprt-183 (Wang et al., 1994) Df(3L)Aprt-188 (Wang et al., 1994) Df(3L)Aprt-190 (Wang et al., 1994) Df(3L)Aprt-196 (Wang et al., 1994) Df(3L)R-G2 (Wang et al., 1994)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD12728} NA P{UAS-EGFP.mu2} NA characterization construct P{mu2+t8.5} NA P{mu2+t10.3} NA P{mu2tA6c} NA
Insertions
	Type of insertions Name Expression data miscellaneous insertions PBac{PB}mu2c02474 NA PBac{RB}mu2e00267 NA PBac{RB}mu2e01793 NA PBac{WH}mu2f01648 NA insertion of enhancer trap binary system PBac{GAL4D,EYFP}mu2PL00250 No
Gene Ontology: Function, Process & Cellular Component ( 1 unique term )
Terms Based on Experimental Evidence ( 1 term )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
double-strand break repair inferred from mutant phenotype (Wei and Rong, 2007)
Cellular Component ( 0 terms)
Terms Based on Predictions or Assertions ( 0 terms )
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions mu2 allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 63784 DroID - A comprehensive database of gene and protein interactions. • FBgn0002872
Orthologs
OrthoDB Orthologs (12) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG6K0R7B Dipteran inclusive ortholog search No orthologs identified Insect inclusive ortholog search No orthologs identified Arthropod inclusive ortholog search No orthologs identified Metazoa inclusive ortholog search No orthologs identified
Orthologs in Drosophila Species (EOG6K0R7B)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\mu2     Drosophila simulans   Dsim\GD13423 Y   Drosophila sechellia   Dsec\GM14153 Y   Drosophila erecta   Dere\GG14544 Y   Drosophila yakuba   Dyak\GE20898 Y   Drosophila ananassae   Dana\GF24946 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA15153 Y   Drosophila persimilis   Dper\GL24813 Y   Drosophila willistoni   Dwil\GK12613 Y   Drosophila virilis   Dvir\GJ13272 Y   Drosophila mojavensis   Dmoj\GI12002 Y   Drosophila grimshawi   Dgri\GH15292 Y
Orthologs in non-Drosophila Dipterans (None identified)
No non-Drosophilid orthologies identified
Orthologs in non-Dipteran Insects (None identified)
No non-Dipteran orthologies identified
Orthologs in non-Insect Arthropods (None identified)
No non-Insect Arthropod orthologies identified
Orthologs in non-Arthropod Metazoa (None identified)
No non-Arthropod Metazoa orthologies identified
Human Orthologs (0)
Gene OMIM HGNC
AAA Orthologs (11) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD13423 Drosophila sechellia Dsec\GM14153 Drosophila erecta Dere\GG14544 Drosophila yakuba Dyak\GE20898 Drosophila ananassae Dana\GF24946 Drosophila pseudoobscura pseudoobscura Dpse\GA15153 Drosophila persimilis Dper\GL24813 Drosophila willistoni Dwil\GK12613 Drosophila virilis Dvir\GJ13272 Drosophila mojavensis Dmoj\GI12002 Drosophila grimshawi Dgri\GH15292
Stocks & Reagents
Stocks Listed in FlyBase ( 13 )
Bloomington	42689 mu2c ca1 awdK 43325 w67c23; P{mu2+t10.3}E1 43636 mwh1 rhove-1 mu21 1220 mu21 st1/TM6C, ca1 43324 y1 w67c23; P{UAS-EGFP.mu2}2/CyO
Harvard	- PBac{PB}mu2c02474 - PBac{RB}mu2e00267 - PBac{WH}mu2f01648
Kyoto	106251 mu21 st1/TM6C, ca1 101895 Dp(1;Y)BS ; mu21 st1
VDRC	v28342 w1118; P{GD12728}v28342 v28343 w1118; P{GD12728}v28343
	More stocks available...
Genomic Clones ( 1 )
	BACR16A03 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 30 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	LD44171
Other clones	IP15561
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	GH15294 GH21591 GM01914 GM26524 LD10692 LD13776 LD21703 LD22674 LD35131 LD36994 LD45035 LP20157 RE02739 RH16561 RH41361 RH46680 RH52937 RH71486 RH71504
Other clones	67458 CK01.54D.F4 EK044454 EK195913 EK212402 IP03930 IP15261 LD09215 LD39253
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0002872 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 38257
Antibody Information
Other Information
Discoverer
	Green, 1977.
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: mu2 CG1960 (Zhong, 1999.11)
Source for database merge of
Additional comments
Other Comments
	dsRNA made from templates generated with primers directed against this gene results in a change in cell proliferation. (Guertin et al., 2006) mu2 controls some aspect of the oocyte nucleus, possibly chromosome structure or association of the chromosomes with the matrix, that modulates both DNA repair and meiotic recombination. (Mason et al., 1997) mu2 gene product potentiates the recovery of terminal (one break) deletions. The putative gene product is associated with oocyte chromosomes and modulates indirectly the repair of broken chromosome ends. Unrepaired broken ends are then 'healed' after fertilization to give terminally deleted chromosomes. mu2 gene product controls a structural element during meiosis that modulates the activity of DNA repair. (Mason and Champion, 1992) mu2 potentiates the recovery of terminal (one break) deletions, a type of chromosomal aberration that is otherwise very rare. (Wang et al., 1992) mu2 gene product potentiates the recovery of terminal (one break) deletions. The putative gene product is associated with oocyte chromosomes and modulates indirectly the repair of broken chromosome ends. Unrepaired broken ends are then 'healed' after fertilization to give terminally deleted chromosomes. (Wang and Mason, 1992)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_079163 NM_167927 NM_001169855 RefSeq (Proteins) • NP_523887 NP_728695 NP_001163326 DDBJ / EMBL / GenBank • AA735664 AAC83937 AAD35085 AAF47597 AAL29023 AAN11507 ACZ94598 AF108206 AF148494 AI239114 AI512334 AW943700 AY061475 CZ467975 CZ478163 CZ479614 CZ479615 CZ484116 Entrez Gene - A searchable database of RefSeq genes. • 38257 UniProtKB/TrEMBL • A2VEF9 O96685 Q9W061 Q95RC8
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • BRCT domain (IPR001357)
Linkouts
	BioGRID - A database of protein and genetic interactions • 63784 DroID - A comprehensive database of gene and protein interactions. • FBgn0002872 DRSC - Results from RNAi screens. • FBgn0002872 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0002872 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG1960-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0002872 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 38257 modMine - Data generated by the modENCODE project. • FBgn0002872
Synonyms & Secondary IDs ( 7 )
Reported As
Symbol Synonym	cDNA D (Kasravi et al., 1999) CG1960 (Mount, 2001.8.14, ) mu-2 (Machado and Andrew, 2000) mu2 (Dronamraju and Mason, 2007, Prasad and Mason, 2007, Mason and Dronamraju, 2007, Guertin et al., 2006, Junell et al., 2007, Wei and Rong, 2007, Kurzhals et al., 2011, Dronamraju and Mason, 2009, Mason, 2013.1.25, Antao et al., 2012) MU2 (Prasad and Mason, 2007, Dronamraju and Mason, 2009) mutator2 (Brand et al., 1997)
Name Synonym	mutator 2
Secondary FlyBase IDs
References ( 45 )
Generate a list of	All references relating to this gene ( 45 )
List References by type	Research paper  ( 15 ) Supplementary material  ( 3 ) Review  ( 2 ) Personal communication to FlyBase  ( 8 ) Abstract  ( 10 ) FlyBase analysis  ( 1 ) Curated genome annotation  ( 2 ) DNA/RNA sequence record  ( 2 ) Book  ( 1 )
Recent research papers ( 5 )
	Antao et al., 2012, Mol. Cell. Biol. 32(12): 2170--2182 Protein Landscape at Drosophila melanogaster Telomere-Associated Sequence Repeats. [FBrf0218429] Beaucher et al., 2012, Genetics 191(2): 407--417 Multiple pathways suppress telomere addition to DNA breaks in the Drosophila germline. [FBrf0218640] Luo and Ye, 2012, FEBS Lett. 586(4): 344--349 Dimerization, but not phosphothreonine binding, is conserved between the forkhead-associated domains of Drosophila MU2 and human MDC1. [FBrf0217526] Dronamraju and Mason, 2011, PLoS ONE 6(9): e25439 MU2 and HP1a Regulate the Recognition of Double Strand Breaks in Drosophila melanogaster. [FBrf0216284] Kurzhals et al., 2011, PLoS Genet. 7(6): e1002103 Chk2 and p53 are haploinsufficient with dependent and independent functions to eliminate cells after telomere loss. [FBrf0216299] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2011 Show reviews ...