mushroom body defective, NuMA
involved in spindle orientation during asymmetric cell division - asymmetrically localized Partner of inscuteable-Gαi complexes regulate spindle orientation by directly binding to Mud which in turn binds microtubules
Gene model reviewed during 5.39
Apparent introns within longest coding exon in cDNAs and RNA-seq junctions within the same region are likely to be artifacts; possibly caused by reverse transcriptase template-switching.
Low-frequency RNA-Seq exon junction(s) not annotated.
Gene model reviewed during 5.45
Gene model reviewed during 5.55
6.003 (longest cDNA)
None of the polypeptides share 100% sequence identity.
2501, 1871 (aa)
Each mud protein isoform is predicted to have a long coiled-coil in the central region, and a carboxy-terminal transmembrane domain. The region predicted to form a coiled-coil includes a segment of 42 amino acids that is repeated 10 times. The 1871 amino acid isoform is predicted to have a single transmembrane segment, whereas the two longer isoforms are predicted to have two transmembrane segments each.
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\mud using the Feature Mapper tool.
GBrowse - Visual display of RNA-Seq signalsView Dmel\mud in GBrowse 2
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Expression is enriched in embryonic gonads.
Mutation of mud interferes with the regulation of central nervous system development by affecting the proliferation pattern.
Neuropil of mushroom bodies (usually in dorsal brain) is missing (Heisenberg, 1980); penetrance for this anatomical phenotype (on which criterion the mutant was isolated) ca. 90%. Calyces that should innervate pedunculi and lobes of mushroom bodies are enlarged, as are antennal lobes in anterior brain. At sites of calyces, large numbers of thin axons form distinct lobes outside main neuropil of brain. Viability of mutant females poor and they are sterile as well. Development of mushroom bodies apparently normal until pupation, when 'reconstruction' of this bilaterally paired brain entity (this process being a normal feature of wild-type metamorphosis) is aberrant (Technau and Heisenberg, 1982). Supernumerary neuroblasts observed in the larval brain, owing to anomalous proliferation of such cells postembryonically.