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Gene Dmel\mus304

General Information
Symbol	Dmel\mus304	Species	D. melanogaster
Name	mutagen-sensitive 304	Annotation symbol	CG7347
Feature type	protein_coding_gene	FlyBase ID	FBgn0002901
Gene Model Status	Current	Stock availability	6 publicly available
Also Known As	ATRIP
Genomic Location
Chromosome (arm)	3L	Recombination map	3-46
Cytogenetic map	75B9-75B10	Sequence location	3L:18,102,897..18,105,947 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene mutagen-sensitive 304 is referred to in FlyBase by the symbol Dmel\mus304 (CG7347, FBgn0002901). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: ATP-dependent DNA helicase activity. There is experimental evidence that it is involved in the biological process: female meiosis chromosome segregation; reciprocal meiotic recombination; female meiosis; DNA repair; telomere maintenance; mitotic cell cycle G2/M transition DNA damage checkpoint; regulation of syncytial blastoderm mitotic cell cycle; DNA damage checkpoint. 15 alleles are reported. The phenotypes of these alleles are annotated with: cycle 13 embryo; wing disc; mitotic cell cycle; macrochaeta; cycle 12 embryo; mesothoracic tergum; cycle 14 embryo. It has one annotated transcript and one annotated polypeptide. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of very low expression. Peak expression observed within 00-06 hour embryonic stages. Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: adult ovary, adult testis. Comments on Affy2 ProbeSet: ProbeSet 1638933_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of mus304. Gene sequence location is 3L:18102897..18105947.
Phenotypic Description from the Red Book (Lindsley & Zimm 1992)
Gene/Allele symbols may differ from current usage	mus304 (J.B. Boyd) Larval survival hypersensitive to exposure to methyl methanesulfonate and nitrogen mustard. Neither hypermutable to alkylating agents nor defective in alkylation repair pathway; however, defective in UV-damage repair pathway (Smith and Dusenberg, 1988, Mechanisms and Consequences of DNA Damage Processing, Alan R. Liss, Inc., pp. 251-55). When fertile, homozygous females exhibit uniformly decreased recombination along the X chromosome (Green, 1982, Biol. Zentralbl. 101: 223-26). Partially deficient in post-replication repair (Boyd and Shaw, 1982, Mol. Gen. Genet. 186: 289-94) and excision (Boyd and Harris, 1981, Chromosoma 97: 607-23); DNA synthesis modified (Boyd and Shaw).
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2011_10
FB2012_01	Sequence features BKN23604 HFA11372
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 75B9-75B10   Limits computationally determined from genome sequence between P{lacW}l(3)j11B2j11B2 and P{PZ}W05014
Experimentally Determined Cytological Location
Cytogenetic map Notes References 75B-75B     (Brodsky, 2000.1.13)
Experimentally Determined Recombination Data
Location	3-46   3- (Boyd et al., 1981)
Left of (cM)	cu (Boyd et al., 1981)
Right of (cM)	st (Boyd et al., 1981)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\mus304 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) mus304-RA FBtr0075122  NM_079411   2833   846
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein mus304-PA   FBpp0074888   96.1   846   6.55     NP_524135   AAF49277
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA201912   AA950556   AA979073   AE014296 AAF49277   AF224715 AAF43388   AI404661   AI405759   AI512826   AI516616   AI518856   AW943749   AX154733   AY118585 AAM49954   BF496080   BF503232   BF503943   BG638705   BI373269   CK131978   CO179097   CO179105   EC058378   EC253965   GH747657   GH750704   GH751619   GH754648   GH756184   GH758386   GH778557   GH783355   GH794431   GH796536   GH801689   GH806368   GH817764   GH822006   GH829422   GH830390   GH838574   GH840298   GH847531   GH850043   GH855158   GH862746   GH863056   GH863655   GH863702   GH876179   GH876984   GH877673   GH887634   GH893669   GH900390   GH901921   GH902646   GH920485   GH923780   GH924084   GH924617   GH933182
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q9VVN4
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic cycle 1 -- embryonic cycle 13   organism | ubiquitous & uniform   (Brodsky et al., 2000) adult stage | femaleoogenesis stage S5 -- S14   nurse cell   (Brodsky et al., 2000) oocyte   (Brodsky et al., 2000)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0002901    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0002901 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of very low expression. Peak expression observed within 00-06 hour embryonic stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0002901 expression level Developmental Stage   Expression Level embryo 00-02hr    1644 embryo 02-04hr    1062 embryo 04-06hr    632 embryo 06-08hr    354 embryo 08-10hr    474 embryo 10-12hr    249 embryo 12-14hr    380 embryo 14-16hr    343 embryo 16-18hr    250 embryo 18-20hr    83 embryo 20-22hr    172 embryo 22-24hr    323 larva L1    95 larva L2    107 larva L3 12hr old    102 larva L3 puffstage 1-2    174 larva L3 puffstage 3-6    263 larva L3 puffstage 7-9    321 white prepupae new    302 white prepupae 12hr    360 white prepupae 24hr    414 pupae 2d postWPP    306 pupae 3d postWPP    186 pupae 4d postWPP    140 adult male 01day    262 adult male 05day    377 adult male 30day    329 adult female 01day    338 adult female 05day    985 adult female 30day    1000 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (1644) embryo 02-04hr  (1062) embryo 04-06hr  (632) embryo 06-08hr  (354) embryo 08-10hr  (474) embryo 10-12hr  (249) embryo 12-14hr  (380) embryo 14-16hr  (343) embryo 16-18hr  (250) embryo 18-20hr    83 embryo 20-22hr  (172) embryo 22-24hr  (323) larva L1    95 larva L2  107 larva L3 12hr old  102 larva L3 puffstage 1-2  (174) larva L3 puffstage 3-6  (263) larva L3 puffstage 7-9  (321) white prepupae new  (302) white prepupae 12hr  (360) white prepupae 24hr  (414) pupae 2d postWPP  (306) pupae 3d postWPP  (186) pupae 4d postWPP  (140) adult male 01day  (262) adult male 05day  (377) adult male 30day  (329) adult female 01day  (338) adult female 05day  (985) adult female 30day  (1000) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (1644) embryo 02-04hr    1062 embryo 04-06hr    632 embryo 06-08hr    354 embryo 08-10hr    474 embryo 10-12hr    249 embryo 12-14hr    380 embryo 14-16hr    343 embryo 16-18hr    250 embryo 18-20hr    83 embryo 20-22hr    172 embryo 22-24hr    323 larva L1    95 larva L2    107 larva L3 12hr old    102 larva L3 puffstage 1-2    174 larva L3 puffstage 3-6    263 larva L3 puffstage 7-9    321 white prepupae new    302 white prepupae 12hr    360 white prepupae 24hr    414 pupae 2d postWPP    306 pupae 3d postWPP    186 pupae 4d postWPP    140 adult male 01day    262 adult male 05day    377 adult male 30day    329 adult female 01day    338 adult female 05day    985 adult female 30day    1000 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    1644 embryo 02-04hr    1062 embryo 04-06hr    632 embryo 06-08hr    354 embryo 08-10hr    474 embryo 10-12hr    249 embryo 12-14hr    380 embryo 14-16hr    343 embryo 16-18hr    250 embryo 18-20hr    83 embryo 20-22hr    172 embryo 22-24hr    323 larva L1    95 larva L2    107 larva L3 12hr old    102 larva L3 puffstage 1-2    174 larva L3 puffstage 3-6    263 larva L3 puffstage 7-9    321 white prepupae new    302 white prepupae 12hr    360 white prepupae 24hr    414 pupae 2d postWPP    306 pupae 3d postWPP    186 pupae 4d postWPP    140 adult male 01day    262 adult male 05day    377 adult male 30day    329 adult female 01day    338 adult female 05day    985 adult female 30day    1000 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    1644 embryo 02-04hr    1062 embryo 04-06hr    632 embryo 06-08hr    354 embryo 08-10hr    474 embryo 10-12hr    249 embryo 12-14hr    380 embryo 14-16hr    343 embryo 16-18hr    250 embryo 18-20hr    83 embryo 20-22hr    172 embryo 22-24hr    323 larva L1    95 larva L2    107 larva L3 12hr old    102 larva L3 puffstage 1-2    174 larva L3 puffstage 3-6    263 larva L3 puffstage 7-9    321 white prepupae new    302 white prepupae 12hr    360 white prepupae 24hr    414 pupae 2d postWPP    306 pupae 3d postWPP    186 pupae 4d postWPP    140 adult male 01day    262 adult male 05day    377 adult male 30day    329 adult female 01day    338 adult female 05day    985 adult female 30day    1000 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0002901 expression level Developmental Stage   Expression Level embryo 00-02hr    1644 embryo 02-04hr    1062 embryo 04-06hr    632 embryo 06-08hr    354 embryo 08-10hr    474 embryo 10-12hr    249 embryo 12-14hr    380 embryo 14-16hr    343 embryo 16-18hr    250 embryo 18-20hr    83 embryo 20-22hr    172 embryo 22-24hr    323 larva L1    95 larva L2    107 larva L3 12hr old    102 larva L3 puffstage 1-2    174 larva L3 puffstage 3-6    263 larva L3 puffstage 7-9    321 white prepupae new    302 white prepupae 12hr    360 white prepupae 24hr    414 pupae 2d postWPP    306 pupae 3d postWPP    186 pupae 4d postWPP    140 adult male 01day    262 adult male 05day    377 adult male 30day    329 adult female 01day    338 adult female 05day    985 adult female 30day    1000 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (1644) embryo 02-04hr  (1062) embryo 04-06hr  (632) embryo 06-08hr  (354) embryo 08-10hr  (474) embryo 10-12hr  (249) embryo 12-14hr  (380) embryo 14-16hr  (343) embryo 16-18hr  (250) embryo 18-20hr    83 embryo 20-22hr  (172) embryo 22-24hr  (323) larva L1    95 larva L2  107 larva L3 12hr old  102 larva L3 puffstage 1-2  (174) larva L3 puffstage 3-6  (263) larva L3 puffstage 7-9  (321) white prepupae new  (302) white prepupae 12hr  (360) white prepupae 24hr  (414) pupae 2d postWPP  (306) pupae 3d postWPP  (186) pupae 4d postWPP  140 adult male 01day  (262) adult male 05day  (377) adult male 30day  (329) adult female 01day  (338) adult female 05day  (985) adult female 30day  (1000) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  1644 embryo 02-04hr    1062 embryo 04-06hr    632 embryo 06-08hr    354 embryo 08-10hr    474 embryo 10-12hr    249 embryo 12-14hr    380 embryo 14-16hr    343 embryo 16-18hr    250 embryo 18-20hr    83 embryo 20-22hr    172 embryo 22-24hr    323 larva L1    95 larva L2    107 larva L3 12hr old    102 larva L3 puffstage 1-2    174 larva L3 puffstage 3-6    263 larva L3 puffstage 7-9    321 white prepupae new    302 white prepupae 12hr    360 white prepupae 24hr    414 pupae 2d postWPP    306 pupae 3d postWPP    186 pupae 4d postWPP    140 adult male 01day    262 adult male 05day    377 adult male 30day    329 adult female 01day    338 adult female 05day    985 adult female 30day    1000 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    1644 embryo 02-04hr    1062 embryo 04-06hr    632 embryo 06-08hr    354 embryo 08-10hr    474 embryo 10-12hr    249 embryo 12-14hr    380 embryo 14-16hr    343 embryo 16-18hr    250 embryo 18-20hr    83 embryo 20-22hr    172 embryo 22-24hr    323 larva L1    95 larva L2    107 larva L3 12hr old    102 larva L3 puffstage 1-2    174 larva L3 puffstage 3-6    263 larva L3 puffstage 7-9    321 white prepupae new    302 white prepupae 12hr    360 white prepupae 24hr    414 pupae 2d postWPP    306 pupae 3d postWPP    186 pupae 4d postWPP    140 adult male 01day    262 adult male 05day    377 adult male 30day    329 adult female 01day    338 adult female 05day    985 adult female 30day    1000 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    1644 embryo 02-04hr    1062 embryo 04-06hr    632 embryo 06-08hr    354 embryo 08-10hr    474 embryo 10-12hr    249 embryo 12-14hr    380 embryo 14-16hr    343 embryo 16-18hr    250 embryo 18-20hr    83 embryo 20-22hr    172 embryo 22-24hr    323 larva L1    95 larva L2    107 larva L3 12hr old    102 larva L3 puffstage 1-2    174 larva L3 puffstage 3-6    263 larva L3 puffstage 7-9    321 white prepupae new    302 white prepupae 12hr    360 white prepupae 24hr    414 pupae 2d postWPP    306 pupae 3d postWPP    186 pupae 4d postWPP    140 adult male 01day    262 adult male 05day    377 adult male 30day    329 adult female 01day    338 adult female 05day    985 adult female 30day    1000 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0002901    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0002901 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: adult ovary, adult testis. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0002901 expression level Tissue   Expression Level Larval Central Nervous System    48.325 Larval Midgut no informative data Larval Hindgut    28.1 Larval Malpighian Tubules    38.5 Larval Fat Body    43.6 Larval Salivary Gland    49.4 Larval Trachea    36.05 Larval Carcass    32.775 Adult Head no informative data Adult Eye no informative data Adult Brain    30.5 Adult Thoracic-Abdominal Ganglion    33.2 Adult Crop    29.3 Adult Midgut    29.3 Adult Hindgut no informative data Adult Malpighian Tubules no informative data Adult Fat Body no informative data Adult Salivary Gland no informative data Adult Heart no informative data Adult VirginFemale Spermatheca    24.6 Adult InseminatedFemale Spermatheca    24.8 Adult Ovary    162.3 Adult Testis    101.6 Adult Male Accessory Gland no informative data Adult Carcass no informative data Expression Level Scale  None   Low   Moderate  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    48.325 Larval Midgut no informative data Larval Hindgut    28.1 Larval Malpighian Tubules    38.5 Larval Fat Body    43.6 Larval Salivary Gland    49.4 Larval Trachea    36.05 Larval Carcass    32.775 Adult Head no informative data Adult Eye no informative data Adult Brain    30.5 Adult Thoracic-Abdominal Ganglion    33.2 Adult Crop    29.3 Adult Midgut    29.3 Adult Hindgut no informative data Adult Malpighian Tubules no informative data Adult Fat Body no informative data Adult Salivary Gland no informative data Adult Heart no informative data Adult VirginFemale Spermatheca    24.6 Adult InseminatedFemale Spermatheca    24.8 Adult Ovary    162.3 Adult Testis    101.6 Adult Male Accessory Gland no informative data Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    48.325 Larval Midgut no informative data Larval Hindgut    28.1 Larval Malpighian Tubules    38.5 Larval Fat Body    43.6 Larval Salivary Gland    49.4 Larval Trachea    36.05 Larval Carcass    32.775 Adult Head no informative data Adult Eye no informative data Adult Brain    30.5 Adult Thoracic-Abdominal Ganglion    33.2 Adult Crop    29.3 Adult Midgut    29.3 Adult Hindgut no informative data Adult Malpighian Tubules no informative data Adult Fat Body no informative data Adult Salivary Gland no informative data Adult Heart no informative data Adult VirginFemale Spermatheca    24.6 Adult InseminatedFemale Spermatheca    24.8 Adult Ovary    162.3 Adult Testis    101.6 Adult Male Accessory Gland no informative data Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    48.325 Larval Midgut no informative data Larval Hindgut    28.1 Larval Malpighian Tubules    38.5 Larval Fat Body    43.6 Larval Salivary Gland    49.4 Larval Trachea    36.05 Larval Carcass    32.775 Adult Head no informative data Adult Eye no informative data Adult Brain    30.5 Adult Thoracic-Abdominal Ganglion    33.2 Adult Crop    29.3 Adult Midgut    29.3 Adult Hindgut no informative data Adult Malpighian Tubules no informative data Adult Fat Body no informative data Adult Salivary Gland no informative data Adult Heart no informative data Adult VirginFemale Spermatheca    24.6 Adult InseminatedFemale Spermatheca    24.8 Adult Ovary    162.3 Adult Testis    101.6 Adult Male Accessory Gland no informative data Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0002901 expression level Tissue   Expression Level Larval Central Nervous System    48.325 Larval Midgut no informative data Larval Hindgut    28.1 Larval Malpighian Tubules    38.5 Larval Fat Body    43.6 Larval Salivary Gland    49.4 Larval Trachea    36.05 Larval Carcass    32.775 Adult Head no informative data Adult Eye no informative data Adult Brain    30.5 Adult Thoracic-Abdominal Ganglion    33.2 Adult Crop    29.3 Adult Midgut    29.3 Adult Hindgut no informative data Adult Malpighian Tubules no informative data Adult Fat Body no informative data Adult Salivary Gland no informative data Adult Heart no informative data Adult VirginFemale Spermatheca    24.6 Adult InseminatedFemale Spermatheca    24.8 Adult Ovary    162.3 Adult Testis    101.6 Adult Male Accessory Gland no informative data Adult Carcass no informative data Expression Level Scale  None   Low   Moderate  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    48.325 Larval Midgut no informative data Larval Hindgut    28.1 Larval Malpighian Tubules    38.5 Larval Fat Body    43.6 Larval Salivary Gland    49.4 Larval Trachea    36.05 Larval Carcass    32.775 Adult Head no informative data Adult Eye no informative data Adult Brain    30.5 Adult Thoracic-Abdominal Ganglion    33.2 Adult Crop    29.3 Adult Midgut    29.3 Adult Hindgut no informative data Adult Malpighian Tubules no informative data Adult Fat Body no informative data Adult Salivary Gland no informative data Adult Heart no informative data Adult VirginFemale Spermatheca    24.6 Adult InseminatedFemale Spermatheca    24.8 Adult Ovary    162.3 Adult Testis    101.6 Adult Male Accessory Gland no informative data Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    48.325 Larval Midgut no informative data Larval Hindgut    28.1 Larval Malpighian Tubules    38.5 Larval Fat Body    43.6 Larval Salivary Gland    49.4 Larval Trachea    36.05 Larval Carcass    32.775 Adult Head no informative data Adult Eye no informative data Adult Brain    30.5 Adult Thoracic-Abdominal Ganglion    33.2 Adult Crop    29.3 Adult Midgut    29.3 Adult Hindgut no informative data Adult Malpighian Tubules no informative data Adult Fat Body no informative data Adult Salivary Gland no informative data Adult Heart no informative data Adult VirginFemale Spermatheca    24.6 Adult InseminatedFemale Spermatheca    24.8 Adult Ovary    162.3 Adult Testis    101.6 Adult Male Accessory Gland no informative data Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    48.325 Larval Midgut no informative data Larval Hindgut    28.1 Larval Malpighian Tubules    38.5 Larval Fat Body    43.6 Larval Salivary Gland    49.4 Larval Trachea    36.05 Larval Carcass    32.775 Adult Head no informative data Adult Eye no informative data Adult Brain    30.5 Adult Thoracic-Abdominal Ganglion    33.2 Adult Crop    29.3 Adult Midgut    29.3 Adult Hindgut no informative data Adult Malpighian Tubules no informative data Adult Fat Body no informative data Adult Salivary Gland no informative data Adult Heart no informative data Adult VirginFemale Spermatheca    24.6 Adult InseminatedFemale Spermatheca    24.8 Adult Ovary    162.3 Adult Testis    101.6 Adult Male Accessory Gland no informative data Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut no informative data Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head no informative data Adult Eye no informative data Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut no informative data Adult Malpighian Tubules no informative data Adult Fat Body no informative data Adult Salivary Gland no informative data Adult Heart no informative data Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland no informative data Adult Carcass no informative data FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    no informative data   NA  Eye    no informative data   NA  Brain    30.5   48.325  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    33.2   NA  Crop    29.3   no informative data  Midgut    29.3   28.1  Hindgut    no informative data   38.5  Malpighian Tubules    no informative data   43.6  Fat Body    no informative data   49.4  Salivary Gland    no informative data   NA  Heart    no informative data   36.05  Trachea    NA   NA  VirginFemale Spermatheca    24.6   NA  InseminatedFemale Spermatheca    24.8   NA  Ovary    162.3   NA  Testis    101.6   NA  Male Accessory Gland    no informative data   32.775  Carcass    no informative data modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_13
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0002901 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG7347-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele viable mus3044 mus3045 mus3046 mus304ZIII-0610 mus304ZIII-2785 viable, with Scer\GAL4pnr-MD237 mus304GD4217 Other Phenotypes Allele chemical sensitive mus304ZIII-0610 mus304ZIII-2785 chemical sensitive | recessive mus304D1 mus304D2 mus304D3 DNA repair defective mus304D3 increased cell death mus304unspecified meiotic cell cycle defective | recessive mus304D1 mus304D3 mitotic cell cycle defective | recessive mus304unspecified radiation sensitive | recessive mus304D1 visible, with Scer\GAL4pnr-MD237 mus304GD4217 visible | recessive mus3044 mus3045 mus3046 mus304D1 mus304D2 wild-type mus304T:Zzzz\FLAG Phenotype manifest in Allele cycle 12 embryo mus304unspecified cycle 13 embryo mus304unspecified cycle 14 embryo mus304unspecified macrochaeta mus3044 mus3045 mus3046 mus304D1 mus304D2 mesothoracic tergum, with Scer\GAL4pnr-MD237 mus304GD4217 mitosis & nuclear chromosome mus304unspecified mitotic cell cycle mus304unspecified nucleus | embryonic stage mus304unspecified wing disc mus304unspecified
Classical Alleles ( 10 )
For All Classical Alleles Show
Allele of mus304 Class Mutagen Stocks Known lesion mus304D1 ethyl methanesulfonate 2 Yes mus304D3 ethyl methanesulfonate 2 Yes mus3044 ethyl methanesulfonate 0 Yes mus3045 ethyl methanesulfonate 0 Yes mus3046 ethyl methanesulfonate 0 Yes mus304D2 ethyl methanesulfonate 0 Yes mus304D4 0 -- mus304unspecified 0 -- mus304ZIII-0610 ethyl methanesulfonate 0 -- mus304ZIII-2785 ethyl methanesulfonate 0 --
Alleles Carried on Transgenic Constructs ( 5 )
For All Alleles Carried on Transgenic Constructs Show
Allele of mus304 Class Mutagen Stocks Known lesion mus304GD4217 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes mus304GUS.T:Hsap\MYC in vitro construct - coding region fusion in vitro construct - regulatory fusion 0 Yes mus304GUS.T:Zzzz\FLAG in vitro construct - coding region fusion in vitro construct - regulatory fusion 0 Yes mus304T:Hsap\MYC in vitro construct - coding region fusion in vitro construct - regulatory fusion 0 Yes mus304T:Zzzz\FLAG in vitro construct - coding region fusion in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(3L)Exel6133 (Ryder, 2004.4.26) Df(3L)W4 (Brodsky et al., 2000) Df(3L)x37 (Brodsky et al., 2000)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD4217} NA characterization construct P{mus304GUS.T:Hsap\MYC} NA P{mus304GUS.T:Zzzz\FLAG} NA P{mus304T:Hsap\MYC} NA P{mus304T:Zzzz\FLAG} NA
Insertions
	Type of insertions Name Expression data
Gene Ontology: Function, Process & Cellular Component ( 15 unique terms )
Terms Based on Experimental Evidence ( 9 terms )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
DNA damage checkpoint inferred from mutant phenotype (Brodsky et al., 2000) DNA repair inferred from mutant phenotype (Brodsky et al., 2000) female meiosis inferred from mutant phenotype (Brodsky et al., 2000) female meiosis chromosome segregation inferred from mutant phenotype (Brodsky et al., 2000) mitotic cell cycle G2/M transition DNA damage checkpoint inferred from genetic interaction with nbs (Kondo and Perrimon, 2011) reciprocal meiotic recombination inferred from mutant phenotype (Brodsky et al., 2000) regulation of syncytial blastoderm mitotic cell cycle inferred from mutant phenotype (Brodsky et al., 2000) telomere maintenance inferred from genetic interaction with tefu (Bi et al., 2005)
Cellular Component
CV term Evidence References
cytoplasm inferred from direct assay (Brodsky et al., 2000)
Terms Based on Predictions or Assertions ( 7 terms )
Molecular Function
CV term Evidence References
ATP-dependent DNA helicase activity inferred from sequence or structural similarity (Sekelsky et al., 1998)
Biological Process
CV term Evidence References
cell cycle checkpoint traceable author statement (Lee and Orr-Weaver, 2003) imaginal disc development traceable author statement (Walworth, 2000) mitotic cell cycle checkpoint traceable author statement (Walworth, 2000) response to DNA damage stimulus non-traceable author statement (Brodsky, 2000.1.13) response to radiation traceable author statement (Walworth, 2000)
Cellular Component
CV term Evidence References
cytoplasm traceable author statement (Lee and Orr-Weaver, 2003)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions mus304 allele Gene References mus304D1 DNApol-α180 (Brodsky et al., 2000) mus304D2 DNApol-α180 (Brodsky et al., 2000)
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 65288 DroID - A comprehensive database of gene and protein interactions. • FBgn0002901 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 40003
Orthologs
Genome-wide drosophilid orthologs	Dana\GF23614 Dere\GG13649 Dgri\GH10057 Dmoj\GI16418 Dper\GL22861 Dpse\GA23899 Dsec\GM14964 Dsim\GD14744 Dvir\GJ16213 Dwil\GK21090 Dyak\GE19943
Curated drosophilid orthologs	Dpse\GA20282   Dsim\mus304 (Anderson et al., 2009)
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL002238-PA Aedes aegypti (mosquito) AGAP008194-PA Anopheles gambiae (mosquito) XP_001949425.1 Acyrthosiphon pisum (pea aphid) ENSBTAP00000048150 Bos taurus (bovine) ENSCAFP00000018463 Canis familiaris (dog) CPIJ004338 Culex pipens (mosquito) ENSGACP00000005672 Gymnopilus aculeatus (mushroom) ENSP00000323099 Homo sapiens (human) ENSMODP00000027806 Monodelphis domestica (gray opossum) ENSMMUP00000013155 Macaca mulatta (rhesus monkey) ENSMUSP00000044831 Mus musculus (house mouse) PHUM008542-PA Pediculus humanus (human body louse) ENSPPYP00000015553 Pongo pygmaeus (orangutan) ENSPTRP00000025685 Pan troglodytes (chimpanzee) ENSRNOP00000028055 Rattus norvegicus (norway rat) ENSXETP00000045231 Xenopus tropicalis (frog) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • FBgn0237272 FBgn0223082 FBgn0203398 FBgn0186419 FBgn0169885 FBgn0245298 FBgn0160451 FBgn0139166 FBgn0117538 FBgn0105913 FBgn0100608 CPIJ004338 BGIBMGA009371 AGAP008194 AAEL002238 PHUM319020
Stocks & Reagents
Stocks Listed in FlyBase ( 6 )
Bloomington	923 st1 mus304D3 922 st1 mus304D1/TM3, Sb1 Ser1
Kyoto	106127 st1 mus304D3 106126 st1 mus304D1/TM3, Sb1 Ser1
VDRC	v46012 w1118 P{GD4217}v46012 v46011 w1118; P{GD4217}v46011/TM3
Genomic Clones ( 1 )
	BACR26J11 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 55 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	LD44887
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	AT05183 AT09880 AT19171 GH24454 GH25881 LD03994 LD30404 LD35263 LD42540 LP13121 RE60526
Other clones	214509.49 CK01.74B.D6 EK058403 EK058447 LD33335 RP003032532 RP003037218 RP003052724 RP003057842 RP003098266 RP003118806 RP003161418 RP003165073 RP003168822 RP003177562 RP003188911 RP003197120 RP003198579 RP003240960 RP003248730 RP003253743 RP003297103 RP003299716 RP003341218 RP003345099 RP003346186 RP003348746 RP003348842 RP003352434 RP003354049 RP003359949 RP003369343 RP003507539 RP003514823 RP003525070 RP003530771 RP003542200 RP003581128 RP003593152 RP003620618 RP003644930 RP003653554 RP003675018
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0002901 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 40003
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of	Source for merge of: mus304 anon-WO0140519.82 (FlyBase, 1996-) Source for merge of: mus304 CG7347 (Millburn, 2000.4.17)
Additional comments	Source for merge of mus304 anon-WO0140519.82 was sequence comparison (date:051113). (FlyBase, 1996-)
Other Comments
	mus304 is essential for cell cycle arrest at high doses of X-irradiation. (Oikemus et al., 2006) mus304 is required for a functional DNA damage checkpoint in the developing eye. (Brodsky et al., 2000) Gene is involved in post-replication recombination repair. (de Buendia, 1998) Larval survival hypersensitive to exposure to methyl methanesulfonate and nitrogen mustard. Neither hypermutable to alkylating agents nor defective in alkylation repair pathway; however, defective in UV-damage repair pathway (Smith and Dusenbery, 1988). When fertile, homozygous females exhibit uniformly decreased recombination along the X chromosome (Green, 1982). Partially deficient in post-replication repair (Boyd and Shaw, 1982) and excision (Boyd and Harris, 1981); DNA synthesis modified (Boyd and Shaw, 1982).
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_079411 RefSeq (Proteins) • NP_524135 DDBJ / EMBL / GenBank • AAF43388 AAF49277 AAM49954 AF224715 AI512826 AW943749 AX154733 AY118585 Entrez Gene - A searchable database of RefSeq genes. • 40003 UniProtKB/TrEMBL • Q9VVN4
Other Crossreferences
Linkouts
	BioGRID - A database of protein and genetic interactions • 65288 DroID - A comprehensive database of gene and protein interactions. • FBgn0002901 DRSC - Results from RNAi screens. • FBgn0002901 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0002901 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG7347-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0002901 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 40003 InParanoid A subset of ortholog calls from InParanoid. • AAEL002238-PA Aedes aegypti (mosquito) AGAP008194-PA Anopheles gambiae (mosquito) XP_001949425.1 Acyrthosiphon pisum (pea aphid) ENSBTAP00000048150 Bos taurus (bovine) ENSCAFP00000018463 Canis familiaris (dog) CPIJ004338 Culex pipens (mosquito) ENSGACP00000005672 Gymnopilus aculeatus (mushroom) ENSP00000323099 Homo sapiens (human) ENSMODP00000027806 Monodelphis domestica (gray opossum) ENSMMUP00000013155 Macaca mulatta (rhesus monkey) ENSMUSP00000044831 Mus musculus (house mouse) PHUM008542-PA Pediculus humanus (human body louse) ENSPPYP00000015553 Pongo pygmaeus (orangutan) ENSPTRP00000025685 Pan troglodytes (chimpanzee) ENSRNOP00000028055 Rattus norvegicus (norway rat) ENSXETP00000045231 Xenopus tropicalis (frog) InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 40003 modMine - Data generated by the modENCODE project. • FBgn0002901 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • FBgn0237272 FBgn0223082 FBgn0203398 FBgn0186419 FBgn0169885 FBgn0245298 FBgn0160451 FBgn0139166 FBgn0117538 FBgn0105913 FBgn0100608 CPIJ004338 BGIBMGA009371 AGAP008194 AAEL002238 PHUM319020
Synonyms & Secondary IDs ( 11 )
Reported As
Symbol Synonym	anon-WO0140519.82   ATRIP (Cenci et al., 2008, Rong, 2008, Kondo and Perrimon, 2011) atrip (Oikemus et al., 2006, Morciano et al., 2009) CG7347 (Millburn, 2000.4.17, ) mus-304 (Walworth, 2000) mus304 (Mukai et al., 2006, Bi et al., 2005, LaRocque et al., 2007, Cenci et al., 2008, Oikemus et al., 2006, Wei and Rong, 2007, Anderson et al., 2009, Musarò et al., 2008, Morciano et al., 2009, Radcliffe et al., 2002, Kondo and Perrimon, 2011, Reis et al., 2011) Mus304 (Hochwagen, 2006) mus(3)304 (The Moscow Regional Drosophila melanogaster Stock Center, Dubna)
Name Synonym	ATR-interacting protein (Rong, 2008) mutagen-sensitive 304 (Mukai et al., 2006) mutagen sensitive 304 (Morciano et al., 2009)
Secondary FlyBase IDs
	FBgn0036776 FBgn0044544
References ( 48 )
Generate a list of	All references relating to this gene ( 48 )
List References by type	Research paper  ( 25 ) Supplementary material  ( 3 ) Review  ( 6 ) Personal communication to FlyBase  ( 3 ) Abstract  ( 4 ) FlyBase analysis  ( 1 ) Stock list  ( 1 ) DNA/RNA sequence record  ( 1 ) Computer file  ( 1 ) Automatic genome annotation  ( 1 ) Patent  ( 1 ) Conference report  ( 1 )
Recent research papers ( 2 )
	Kondo and Perrimon, 2011, Sci. Signal. 4(154): rs1 A Genome-Wide RNAi Screen Identifies Core Components of the G2-M DNA Damage Checkpoint. [FBrf0212700] Reis et al., 2011, PLoS ONE 6(3): e17512 Drosophila Genes That Affect Meiosis Duration Are among the Meiosis Related Genes That Are More Often Found Duplicated. [FBrf0213266] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2010 Show reviews ...