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Gene Dmel\Myb

General Information
Symbol	Dmel\Myb	Species	D. melanogaster
Name	Myb oncogene-like	Annotation symbol	CG9045
Feature type	protein_coding_gene	FlyBase ID	FBgn0002914
Gene Model Status	Current	Stock availability	8 publicly available
Also Known As	Dm-Myb, Dm myb, dMyb, c-Myb, DmMyb, D-myb
Genomic Location
Chromosome (arm)	X	Recombination map
Cytogenetic map	13F14-13F14	Sequence location	X:15,748,865..15,751,854 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Myb oncogene-like is referred to in FlyBase by the symbol Dmel\Myb (CG9045, FBgn0002914). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: DNA binding. There is experimental evidence for 14 unique biological process terms, many of which group under: cellular component organization or biogenesis; cell cycle; organelle organization; cell cycle process; biological regulation; cellular process involved in reproduction; cell proliferation; microtubule organizing center organization; cell division; regulation of biological process. 45 alleles are reported. The phenotypes of these alleles are annotated with: cell cycle; adult segment; organ system subdivision; external compound sense organ; cell cycle process; imaginal precursor; nuclear part; cellular component organization or biogenesis; dorsal thoracic disc; embryonic/larval hemocoel. It has 5 annotated transcripts and 5 annotated polypeptides. Protein features are: C-myb, C-terminal; Homeodomain-like; Homeodomain-related; MYB-like; Myb transcription factor; Myb, DNA-binding; SANT domain, DNA binding; Transcription regulator HTH, Myb-type, DNA-binding. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed within 00-18 hour embryonic stages, during early pupal stages. Summary of FlyAtlas Anatomical Expression Data: Nearly all larval and adult tissues/organs expressed at moderate levels. Expression at high levels in the following post-embryonic organs or tissues: larval central nervous system. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, larval/adult salivary gland, larval trachea, adult female reproductive system, adult male reproductive system, larval/adult carcass. Comments on Affy2 ProbeSet: ProbeSet 1627567_at completely aligns to an exonic region common to each of the 5 FlyBase-annotated transcript isoforms of Myb. Gene sequence location is X:15748865..15751854.
External Summaries
Phenotypic Description from the Red Book (Lindsley & Zimm 1992)
Gene/Allele symbols may differ from current usage	Myb: Myb proto-oncongene sequence Considered to be the Drosophila homologue of avian c-myb. Open reading frame identified to date encodes a polypeptide exhibiting 73% homology with chicken c-myb protein.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2011_10
FB2012_01	Sequence features HFA20260 BKN20863
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 13F14-13F14   Limits computationally determined from genome sequence between P{EP}BEST:RE35685EP1581&P{EP}sdEP1088 and P{EP}Gβ13FEP1071
Experimentally Determined Cytological Location
Cytogenetic map Notes References 13E-13F   (determined by in situ hybridisation)   (Peters et al., 1987) 13F-13F   (determined by in situ hybridisation)   (Katzen et al., 1985)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\Myb for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Myb-RA FBtr0074169  NM_078615   2813   657 Myb-RB FBtr0074170  NM_206734   2755   657 Myb-RC FBtr0074172  NM_206732   2831   657 Myb-RD FBtr0074171  NM_206733   2863   657 Myb-RE FBtr0074173  NM_206731   2926   657
Additional Transcript Data & Comments
Reported size (kB)	3.2 (northern blot) (Katzen and Bishop, 1996) 2.814 (longest cDNA) (Peters et al., 1987)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Myb-PA   FBpp0073961   74.0   657   9.20     NP_511170   AAF48529 Myb-PB   FBpp0089402   74.0   657   9.20     NP_996457   AAS65355 Myb-PC   FBpp0089404   74.0   657   9.20     NP_996455   AAS65356 Myb-PD   FBpp0089403   74.0   657   9.20     NP_996456   AAS65357 Myb-PE   FBpp0089405   74.0   657   9.20     NP_996454   AAS65358
Additional Polypeptide Data & Comments
Reported size (kDa)	657 (aa); 74 (kD predicted) (Peters et al., 1987)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • SANT domain, DNA binding (IPR001005) Homeodomain-like (IPR009057) Homeodomain-related (IPR012287) Myb, DNA-binding (IPR014778) C-myb, C-terminal (IPR015395) Myb transcription factor (IPR015495) MYB-like (IPR017877) Transcription regulator HTH, Myb-type, DNA-binding (IPR017930)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA247073   AA439578   AA440489   AA441656   AA816637   AA817467   AA940734   AA949195   AA949205   AA949242   AA949821   AA979101   AE014298 AAF48529   AE014298 AAS65355   AE014298 AAS65356   AE014298 AAS65357   AE014298 AAS65358   AI134426   AI531195   AI542689   AI546293   BF495599   BF495798   BF497939   BF501021   BF505142   BF505887   BI169183   BI212240   BI215747   BI216632   BI230541   BI230824   BI231441   BI232067   BI232112   BI233216   BI240187   BI241692   BI243629   BI357073   BI363438   BI364355   BI365941   BI368176   BI368271   BI369918   BI371184   BI373136   BI373402   BI374324   BI481643   BI481761   BI482664   BI482994   BI484744   BI567302   BI575462   BI579080   BI583835   BI628288   BI636041   BI636435   BP545188   BP545189   BP547082   BT003262 AAO25019   CK659189   CO177291   CO177648   CO193148   CO265770   CO280405   CO283886   CO300749   CO304464   CO312147   CO313882   CO324557   DN154324   EC073311   EC073952   EC076678   EC091077   EC195673   EC202459   EC204089   EC221023   EC221764   EC236472   EC236741   EC236775   EC237256   EC246758   EC247825   EC249356   EL870361   EV589370   EV589952   EV591799   GH755710   GH756226   GH759298   GH760529   GH760566   GH770789   GH774135   GH775951   GH776677   GH776995   GH778473   GH780873   GH781529   GH782777   GH783008   GH783492   GH790361   GH790685   GH801043   GH801563   GH803966   GH804833   GH809483   GH809612   GH811736   GH815405   GH815444   GH818025   GH818111   GH823373   GH824531   GH826134   GH826456   GH826673   GH829224   GH838933   GH842636   GH843552   GH844470   GH849614   GH850568   GH851470   GH851726   GH853096   GH855236   GH865169   GH870215   GH872865   GH873563   GH873743   GH876695   GH876990   GH884977   GH886842   GH892100   GH892515   GH896112   GH902561   GH905903   GH907191   GH907593   GH909584   GH910811   GH912062   GH912927   GH917737   GH917932   GH918217   GH918554   GH921174   GH922538   GH926745   GH926919   GH933996   GH934280   GH935716   GH940009   GH940242   M11281 AAA70367   X05939 CAA29373
UniProtKB/Swiss-Prot	P04197
UniProtKB/TrEMBL	Q53YG3
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
radioisotope in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage | early     (Katzen and Bishop, 1996) embryonic stage | late   presumptive embryonic/larval central nervous system   (Katzen and Bishop, 1996) third instar larval stage   ovary   (Katzen and Bishop, 1996) testis   (Katzen and Bishop, 1996) imaginal disc   (Katzen and Bishop, 1996) brain   (Katzen and Bishop, 1996) ventral nerve cord   (Katzen and Bishop, 1996) pupal stage | early   adult brain   (Katzen and Bishop, 1996) imaginal disc   (Katzen and Bishop, 1996) thoracico-abdominal ganglion   (Katzen and Bishop, 1996) pupal stage   nervous system   (Katzen and Bishop, 1996) pupal stage -- adult stage   ovary   (Katzen and Bishop, 1996) testis   (Katzen and Bishop, 1996) adult stage   adult brain   (Katzen and Bishop, 1996) thoracico-abdominal ganglion   (Katzen and Bishop, 1996) adult stage & oogenesis   oocyte   (Katzen and Bishop, 1996) nurse cell   (Katzen and Bishop, 1996) RT-PCR Stage Tissue/Position (including subcellular localization) Reference adult stage | female   ovary   (Beall et al., 2004)
Additional Descriptive Data
	The 3.2 kb Myb transcript is detected throughout development. Myb transcript is detected mainly in proliferating tissues, though expression is seen at lower levels in some post-mitotic tissues. Expression is uniform and high in preblastoderm embryos, and continues to be high during cellular blastoderm formation and germ band extension. Message is less uniform in contracted germ band embryos, with no expression seen in the amnioserosa, and low expression in the salivary glands. Later in embryogenesis, Myb transcript is high only in the CNS. In climbing third instar larvae, tissues contributing to the adult express Myb at high levels: imaginal disc, brain, ventral ganglion, testes, ovaries, and nests of imaginal cells in the gut. Expression in these tissues continues in the early pupa, with additional expression detected in histoblasts and epithelial cells of the developing imaginal gut. Myb levels decline in everted imaginal tissues. Ovary, testis, and neural tissue continue to express Myb transcript through pupal development. Myb is detected at low levels in the brain and thoracic ganglia of adults, and expression is high in adult testes and ovaries. (Katzen and Bishop, 1996)
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
immunolocalization Stage Tissue/Position (including subcellular localization) Reference adult stage | female   follicle cell   • nucleus (Beall et al., 2004) western blot Stage Tissue/Position (including subcellular localization) Reference embryonic stage -- adult stage   organism   (Beall et al., 2004)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0002914    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0002914 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed within 00-18 hour embryonic stages, during early pupal stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0002914 expression level Developmental Stage   Expression Level embryo 00-02hr    5419 embryo 02-04hr    6272 embryo 04-06hr    7721 embryo 06-08hr    8652 embryo 08-10hr    7526 embryo 10-12hr    5151 embryo 12-14hr    4574 embryo 14-16hr    3588 embryo 16-18hr    3470 embryo 18-20hr    2610 embryo 20-22hr    3772 embryo 22-24hr    3516 larva L1    1846 larva L2    1321 larva L3 12hr old    1072 larva L3 puffstage 1-2    1643 larva L3 puffstage 3-6    2511 larva L3 puffstage 7-9    3160 white prepupae new    3172 white prepupae 12hr    3650 white prepupae 24hr    4086 pupae 2d postWPP    2590 pupae 3d postWPP    2087 pupae 4d postWPP    1467 adult male 01day    2169 adult male 05day    2560 adult male 30day    2545 adult female 01day    2603 adult female 05day    3865 adult female 30day    3868 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (5419) embryo 02-04hr  (6272) embryo 04-06hr  (7721) embryo 06-08hr  (8652) embryo 08-10hr  (7526) embryo 10-12hr  (5151) embryo 12-14hr  (4574) embryo 14-16hr  (3588) embryo 16-18hr  (3470) embryo 18-20hr  (2610) embryo 20-22hr  (3772) embryo 22-24hr  (3516) larva L1  (1846) larva L2  (1321) larva L3 12hr old  (1072) larva L3 puffstage 1-2  (1643) larva L3 puffstage 3-6  (2511) larva L3 puffstage 7-9  (3160) white prepupae new  (3172) white prepupae 12hr  (3650) white prepupae 24hr  (4086) pupae 2d postWPP  (2590) pupae 3d postWPP  (2087) pupae 4d postWPP  (1467) adult male 01day  (2169) adult male 05day  (2560) adult male 30day  (2545) adult female 01day  (2603) adult female 05day  (3865) adult female 30day  (3868) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (5419) embryo 02-04hr  (6272) embryo 04-06hr  (7721) embryo 06-08hr  (8652) embryo 08-10hr  (7526) embryo 10-12hr  (5151) embryo 12-14hr  (4574) embryo 14-16hr  (3588) embryo 16-18hr  (3470) embryo 18-20hr  (2610) embryo 20-22hr  (3772) embryo 22-24hr  (3516) larva L1  (1846) larva L2    1321 larva L3 12hr old    1072 larva L3 puffstage 1-2  (1643) larva L3 puffstage 3-6  (2511) larva L3 puffstage 7-9  (3160) white prepupae new  (3172) white prepupae 12hr  (3650) white prepupae 24hr  (4086) pupae 2d postWPP  (2590) pupae 3d postWPP  (2087) pupae 4d postWPP  1467 adult male 01day  (2169) adult male 05day  (2560) adult male 30day  (2545) adult female 01day  (2603) adult female 05day  (3865) adult female 30day  (3868) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    5419 embryo 02-04hr    6272 embryo 04-06hr    7721 embryo 06-08hr    8652 embryo 08-10hr    7526 embryo 10-12hr    5151 embryo 12-14hr    4574 embryo 14-16hr    3588 embryo 16-18hr    3470 embryo 18-20hr    2610 embryo 20-22hr    3772 embryo 22-24hr    3516 larva L1    1846 larva L2    1321 larva L3 12hr old    1072 larva L3 puffstage 1-2    1643 larva L3 puffstage 3-6    2511 larva L3 puffstage 7-9    3160 white prepupae new    3172 white prepupae 12hr    3650 white prepupae 24hr    4086 pupae 2d postWPP    2590 pupae 3d postWPP    2087 pupae 4d postWPP    1467 adult male 01day    2169 adult male 05day    2560 adult male 30day    2545 adult female 01day    2603 adult female 05day    3865 adult female 30day    3868 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    5419 embryo 02-04hr    6272 embryo 04-06hr    7721 embryo 06-08hr    8652 embryo 08-10hr    7526 embryo 10-12hr    5151 embryo 12-14hr    4574 embryo 14-16hr    3588 embryo 16-18hr    3470 embryo 18-20hr    2610 embryo 20-22hr    3772 embryo 22-24hr    3516 larva L1    1846 larva L2    1321 larva L3 12hr old    1072 larva L3 puffstage 1-2    1643 larva L3 puffstage 3-6    2511 larva L3 puffstage 7-9    3160 white prepupae new    3172 white prepupae 12hr    3650 white prepupae 24hr    4086 pupae 2d postWPP    2590 pupae 3d postWPP    2087 pupae 4d postWPP    1467 adult male 01day    2169 adult male 05day    2560 adult male 30day    2545 adult female 01day    2603 adult female 05day    3865 adult female 30day    3868 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0002914 expression level Developmental Stage   Expression Level embryo 00-02hr    5419 embryo 02-04hr    6272 embryo 04-06hr    7721 embryo 06-08hr    8652 embryo 08-10hr    7526 embryo 10-12hr    5151 embryo 12-14hr    4574 embryo 14-16hr    3588 embryo 16-18hr    3470 embryo 18-20hr    2610 embryo 20-22hr    3772 embryo 22-24hr    3516 larva L1    1846 larva L2    1321 larva L3 12hr old    1072 larva L3 puffstage 1-2    1643 larva L3 puffstage 3-6    2511 larva L3 puffstage 7-9    3160 white prepupae new    3172 white prepupae 12hr    3650 white prepupae 24hr    4086 pupae 2d postWPP    2590 pupae 3d postWPP    2087 pupae 4d postWPP    1467 adult male 01day    2169 adult male 05day    2560 adult male 30day    2545 adult female 01day    2603 adult female 05day    3865 adult female 30day    3868 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (5419) embryo 02-04hr  (6272) embryo 04-06hr  (7721) embryo 06-08hr  (8652) embryo 08-10hr  (7526) embryo 10-12hr  (5151) embryo 12-14hr  (4574) embryo 14-16hr  (3588) embryo 16-18hr  (3470) embryo 18-20hr  (2610) embryo 20-22hr  (3772) embryo 22-24hr  (3516) larva L1  (1846) larva L2  (1321) larva L3 12hr old  (1072) larva L3 puffstage 1-2  (1643) larva L3 puffstage 3-6  (2511) larva L3 puffstage 7-9  (3160) white prepupae new  (3172) white prepupae 12hr  (3650) white prepupae 24hr  (4086) pupae 2d postWPP  (2590) pupae 3d postWPP  (2087) pupae 4d postWPP  (1467) adult male 01day  (2169) adult male 05day  (2560) adult male 30day  (2545) adult female 01day  (2603) adult female 05day  (3865) adult female 30day  (3868) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (5419) embryo 02-04hr  (6272) embryo 04-06hr  (7721) embryo 06-08hr  (8652) embryo 08-10hr  (7526) embryo 10-12hr  (5151) embryo 12-14hr  (4574) embryo 14-16hr  (3588) embryo 16-18hr  (3470) embryo 18-20hr  (2610) embryo 20-22hr  (3772) embryo 22-24hr  (3516) larva L1  1846 larva L2    1321 larva L3 12hr old    1072 larva L3 puffstage 1-2  1643 larva L3 puffstage 3-6  (2511) larva L3 puffstage 7-9  (3160) white prepupae new  (3172) white prepupae 12hr  (3650) white prepupae 24hr  (4086) pupae 2d postWPP  (2590) pupae 3d postWPP  2087 pupae 4d postWPP  1467 adult male 01day  2169 adult male 05day  (2560) adult male 30day  (2545) adult female 01day  (2603) adult female 05day  (3865) adult female 30day  (3868) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    5419 embryo 02-04hr    6272 embryo 04-06hr    7721 embryo 06-08hr    8652 embryo 08-10hr    7526 embryo 10-12hr    5151 embryo 12-14hr    4574 embryo 14-16hr    3588 embryo 16-18hr    3470 embryo 18-20hr    2610 embryo 20-22hr    3772 embryo 22-24hr    3516 larva L1    1846 larva L2    1321 larva L3 12hr old    1072 larva L3 puffstage 1-2    1643 larva L3 puffstage 3-6    2511 larva L3 puffstage 7-9    3160 white prepupae new    3172 white prepupae 12hr    3650 white prepupae 24hr    4086 pupae 2d postWPP    2590 pupae 3d postWPP    2087 pupae 4d postWPP    1467 adult male 01day    2169 adult male 05day    2560 adult male 30day    2545 adult female 01day    2603 adult female 05day    3865 adult female 30day    3868 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    5419 embryo 02-04hr    6272 embryo 04-06hr    7721 embryo 06-08hr    8652 embryo 08-10hr    7526 embryo 10-12hr    5151 embryo 12-14hr    4574 embryo 14-16hr    3588 embryo 16-18hr    3470 embryo 18-20hr    2610 embryo 20-22hr    3772 embryo 22-24hr    3516 larva L1    1846 larva L2    1321 larva L3 12hr old    1072 larva L3 puffstage 1-2    1643 larva L3 puffstage 3-6    2511 larva L3 puffstage 7-9    3160 white prepupae new    3172 white prepupae 12hr    3650 white prepupae 24hr    4086 pupae 2d postWPP    2590 pupae 3d postWPP    2087 pupae 4d postWPP    1467 adult male 01day    2169 adult male 05day    2560 adult male 30day    2545 adult female 01day    2603 adult female 05day    3865 adult female 30day    3868 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0002914    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0002914 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Nearly all larval and adult tissues/organs expressed at moderate levels. Expression at high levels in the following post-embryonic organs or tissues: larval central nervous system. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, larval/adult salivary gland, larval trachea, adult female reproductive system, adult male reproductive system, larval/adult carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0002914 expression level Tissue   Expression Level Larval Central Nervous System    576.625 Larval Midgut    120.7 Larval Hindgut    167.9 Larval Malpighian Tubules    242.9 Larval Fat Body    163.9 Larval Salivary Gland    155 Larval Trachea    252.825 Larval Carcass    175.375 Adult Head    197.5 Adult Eye    193.025 Adult Brain    276 Adult Thoracic-Abdominal Ganglion    246.8 Adult Crop    240.3 Adult Midgut    158.7 Adult Hindgut    163.5 Adult Malpighian Tubules    148.1 Adult Fat Body    112.8 Adult Salivary Gland    172.4 Adult Heart    104.85 Adult VirginFemale Spermatheca    99.5 Adult InseminatedFemale Spermatheca    109.5 Adult Ovary    340.2 Adult Testis    235.9 Adult Male Accessory Gland    178 Adult Carcass    117.8 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System  (576.625) Larval Midgut    120.7 Larval Hindgut    167.9 Larval Malpighian Tubules    242.9 Larval Fat Body    163.9 Larval Salivary Gland    155 Larval Trachea    252.825 Larval Carcass    175.375 Adult Head    197.5 Adult Eye    193.025 Adult Brain    276 Adult Thoracic-Abdominal Ganglion    246.8 Adult Crop    240.3 Adult Midgut    158.7 Adult Hindgut    163.5 Adult Malpighian Tubules    148.1 Adult Fat Body    112.8 Adult Salivary Gland    172.4 Adult Heart    104.85 Adult VirginFemale Spermatheca    99.5 Adult InseminatedFemale Spermatheca    109.5 Adult Ovary    340.2 Adult Testis    235.9 Adult Male Accessory Gland    178 Adult Carcass    117.8 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    576.625 Larval Midgut    120.7 Larval Hindgut    167.9 Larval Malpighian Tubules    242.9 Larval Fat Body    163.9 Larval Salivary Gland    155 Larval Trachea    252.825 Larval Carcass    175.375 Adult Head    197.5 Adult Eye    193.025 Adult Brain    276 Adult Thoracic-Abdominal Ganglion    246.8 Adult Crop    240.3 Adult Midgut    158.7 Adult Hindgut    163.5 Adult Malpighian Tubules    148.1 Adult Fat Body    112.8 Adult Salivary Gland    172.4 Adult Heart    104.85 Adult VirginFemale Spermatheca    99.5 Adult InseminatedFemale Spermatheca    109.5 Adult Ovary    340.2 Adult Testis    235.9 Adult Male Accessory Gland    178 Adult Carcass    117.8 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    576.625 Larval Midgut    120.7 Larval Hindgut    167.9 Larval Malpighian Tubules    242.9 Larval Fat Body    163.9 Larval Salivary Gland    155 Larval Trachea    252.825 Larval Carcass    175.375 Adult Head    197.5 Adult Eye    193.025 Adult Brain    276 Adult Thoracic-Abdominal Ganglion    246.8 Adult Crop    240.3 Adult Midgut    158.7 Adult Hindgut    163.5 Adult Malpighian Tubules    148.1 Adult Fat Body    112.8 Adult Salivary Gland    172.4 Adult Heart    104.85 Adult VirginFemale Spermatheca    99.5 Adult InseminatedFemale Spermatheca    109.5 Adult Ovary    340.2 Adult Testis    235.9 Adult Male Accessory Gland    178 Adult Carcass    117.8 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0002914 expression level Tissue   Expression Level Larval Central Nervous System    576.625 Larval Midgut    120.7 Larval Hindgut    167.9 Larval Malpighian Tubules    242.9 Larval Fat Body    163.9 Larval Salivary Gland    155 Larval Trachea    252.825 Larval Carcass    175.375 Adult Head    197.5 Adult Eye    193.025 Adult Brain    276 Adult Thoracic-Abdominal Ganglion    246.8 Adult Crop    240.3 Adult Midgut    158.7 Adult Hindgut    163.5 Adult Malpighian Tubules    148.1 Adult Fat Body    112.8 Adult Salivary Gland    172.4 Adult Heart    104.85 Adult VirginFemale Spermatheca    99.5 Adult InseminatedFemale Spermatheca    109.5 Adult Ovary    340.2 Adult Testis    235.9 Adult Male Accessory Gland    178 Adult Carcass    117.8 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System  576.625 Larval Midgut    120.7 Larval Hindgut    167.9 Larval Malpighian Tubules    242.9 Larval Fat Body    163.9 Larval Salivary Gland    155 Larval Trachea    252.825 Larval Carcass    175.375 Adult Head    197.5 Adult Eye    193.025 Adult Brain    276 Adult Thoracic-Abdominal Ganglion    246.8 Adult Crop    240.3 Adult Midgut    158.7 Adult Hindgut    163.5 Adult Malpighian Tubules    148.1 Adult Fat Body    112.8 Adult Salivary Gland    172.4 Adult Heart    104.85 Adult VirginFemale Spermatheca    99.5 Adult InseminatedFemale Spermatheca    109.5 Adult Ovary    340.2 Adult Testis    235.9 Adult Male Accessory Gland    178 Adult Carcass    117.8 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    576.625 Larval Midgut    120.7 Larval Hindgut    167.9 Larval Malpighian Tubules    242.9 Larval Fat Body    163.9 Larval Salivary Gland    155 Larval Trachea    252.825 Larval Carcass    175.375 Adult Head    197.5 Adult Eye    193.025 Adult Brain    276 Adult Thoracic-Abdominal Ganglion    246.8 Adult Crop    240.3 Adult Midgut    158.7 Adult Hindgut    163.5 Adult Malpighian Tubules    148.1 Adult Fat Body    112.8 Adult Salivary Gland    172.4 Adult Heart    104.85 Adult VirginFemale Spermatheca    99.5 Adult InseminatedFemale Spermatheca    109.5 Adult Ovary    340.2 Adult Testis    235.9 Adult Male Accessory Gland    178 Adult Carcass    117.8 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    576.625 Larval Midgut    120.7 Larval Hindgut    167.9 Larval Malpighian Tubules    242.9 Larval Fat Body    163.9 Larval Salivary Gland    155 Larval Trachea    252.825 Larval Carcass    175.375 Adult Head    197.5 Adult Eye    193.025 Adult Brain    276 Adult Thoracic-Abdominal Ganglion    246.8 Adult Crop    240.3 Adult Midgut    158.7 Adult Hindgut    163.5 Adult Malpighian Tubules    148.1 Adult Fat Body    112.8 Adult Salivary Gland    172.4 Adult Heart    104.85 Adult VirginFemale Spermatheca    99.5 Adult InseminatedFemale Spermatheca    109.5 Adult Ovary    340.2 Adult Testis    235.9 Adult Male Accessory Gland    178 Adult Carcass    117.8 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    197.5   NA  Eye    193.025   NA  Brain    276   576.625  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    246.8   NA  Crop    240.3   120.7  Midgut    158.7   167.9  Hindgut    163.5   242.9  Malpighian Tubules    148.1   163.9  Fat Body    112.8   155  Salivary Gland    172.4   NA  Heart    104.85   252.825  Trachea    NA   NA  VirginFemale Spermatheca    99.5   NA  InseminatedFemale Spermatheca    109.5   NA  Ovary    340.2   NA  Testis    235.9   NA  Male Accessory Gland    178   175.375  Carcass    117.8 modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_17
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0002914 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG9045-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal, with Scer\GAL4Act5C.PI MybΔ.Scer\UAS lethal | heat sensitive Myb1 Myb2 lethal | heat sensitive, with Scer\GAL4Act5C.PI MybScer\UAS.cFa lethal | larval stage | recessive Mybel1 Mybel2507 lethal | maternal effect | recessive | heat sensitive Myb1 lethal | recessive MybMH107 lethal | recessive | heat sensitive Myb1 Myb2 Mybel1 viable, with Scer\GAL4pnr-MD237 MybGD4472 Other Phenotypes Allele cell cycle defective | recessive MybMH107 cytokinesis defective MybMH107 increased cell death MybMH107 MybΔC.GMR increased cell death, with Scer\GAL4en-e16E MybScer\UAS.cFa MybΔ.Scer\UAS increased cell death, with Scer\GAL4sd-SG29.1 MybScer\UAS.cFa MybΔ.Scer\UAS mitotic cell cycle defective Myb1 MybMH107 MybΔC.GMR visible, with Scer\GAL4sd-SG29.1 MybScer\UAS.cFa visible | dominant MybΔC.GMR visible | recessive Myb1 Myb2 wild-type Myb+t6.7 Myb+t9.0 Myb+t15 Phenotype manifest in Allele abdomen Myb1 Myb2 abdomen (with Df(1)sd72a) Myb1 Myb2 adult abdomen | maternal effect Myb1 adult abdominal segment Myb1 adult abdominal sensillum Myb1 adult cuticle Myb1 Myb2 adult cuticle (with Df(1)sd72a) Myb2 cell cycle Myb2 cell cycle (with Df(1)sd72a) Myb2 centrosome Myb1 Myb2 MybMH107 centrosome (with Df(1)sd72a) Myb2 chorion | somatic clone MybMH107 chromosome MybMH107 condensed nuclear chromosome MybMH107 crystal cell MybMH107 dorsal appendage | somatic clone MybMH107 embryo Myb1 embryonic/larval lymph gland MybMH107 embryonic/larval salivary gland, with Scer\GAL4fkh.PB MybΔ.Scer\UAS embryonic/larval salivary gland, with Scer\GAL4sd-SG29.1 MybΔ.Scer\UAS MybScer\UAS.cFa eye MybΔC.GMR eye disc MybΔC.GMR eye photoreceptor cell MybΔC.GMR G2 phase MybMH107 haltere disc, with Scer\GAL4en-e16E MybΔ.Scer\UAS hemocyte & nucleus MybMH107 histoblast Myb2 histoblast (with Df(1)sd72a) Myb1 Myb2 macrochaeta Myb1 macrochaeta & wing | maternal effect Myb1 microchaeta Myb1 microchaeta & adult abdomen Myb1 Myb2 microchaeta & wing | maternal effect Myb1 mitosis & nuclear chromosome Myb2 MybMH107 mitosis & nuclear chromosome (with Df(1)sd72a) Myb2 mitotic anaphase MybMH107 mitotic cell cycle Myb2 MybMH107 mitotic cell cycle, with Scer\GAL4en-e16E MybΔ.Scer\UAS MybScer\UAS.cFa mitotic cell cycle, with Scer\GAL4fkh.PB MybΔ.Scer\UAS mitotic cell cycle, with Scer\GAL4sd-SG29.1 MybΔ.Scer\UAS MybScer\UAS.cFa mitotic cell cycle (with Df(1)sd72a) Myb2 mitotic prophase Myb2 mitotic prophase (with Df(1)sd72a) Myb2 M phase of mitotic cell cycle MybMH107 neuroblast MybMH107 nuclear chromosome Myb1 ommatidium MybΔC.GMR plasmatocyte MybMH107 rhabdomere MybΔC.GMR S phase MybMH107 spindle MybMH107 ventral thoracic disc, with Scer\GAL4en-e16E MybScer\UAS.cFa wing Myb1 Myb2 wing, with Scer\GAL4sd-SG29.1 MybScer\UAS.cFa wing & cell Myb1 wing & macrochaeta Myb1 wing & nucleus Myb1 wing | maternal effect Myb1 wing disc, with Scer\GAL4en-e16E MybΔ.Scer\UAS MybScer\UAS.cFa wing disc, with Scer\GAL4sd-SG29.1 MybΔ.Scer\UAS MybScer\UAS.cFa wing hair Myb1 Myb2 wing hair | ectopic Myb1 wing hair | precursor Myb1 wing hair | precursor | supernumerary Myb1 wing sensillum Myb1 wing vein Myb1 wing vein | maternal effect Myb1
Classical Alleles ( 7 )
For All Classical Alleles Show
Allele of Myb Class Mutagen Stocks Known lesion Mybel1 hypomorphic allele - genetic evidence ethyl methanesulfonate 1 Yes Mybel2507 hypomorphic allele - genetic evidence ethyl methanesulfonate 1 -- MybG233 P-element activity 1 -- Myb1 hypomorphic allele - genetic evidence ethyl methanesulfonate 0 Yes Myb2 hypomorphic allele - genetic evidence ethyl methanesulfonate 0 Yes MybMH107 Delta2-3 0 Yes Mybunspecified 0 --
Alleles Carried on Transgenic Constructs ( 38 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Myb Class Mutagen Stocks Known lesion MybGD4472 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes MybHMS01467 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes MybJF02135 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes MybT:Avic\GFP-EGFP in vitro construct - regulatory fusion in vitro construct - coding region fusion 1 Yes Myb+t13 in vitro construct - genomic fragment 0 Yes Myb+t15 in vitro construct - genomic fragment 0 Yes Myb+t6.6 in vitro construct - genomic fragment 0 Yes Myb+t6.7 in vitro construct - genomic fragment 0 Yes Myb+t9.0 in vitro construct - genomic fragment 0 Yes Myb11.6-S:S in vitro construct - genomic fragment 0 Yes Myb6.7-FS-K:B in vitro construct 0 Yes MybAct5C.PH in vitro construct - regulatory fusion 0 Yes MybCMV.cFa in vitro construct - regulatory fusion 0 Yes MybCterm.T:Avic\GFP-EGFP in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes MybdsRNA.cLa in vitro construct - RNAi 0 Yes MybdsRNA.cOa in vitro construct - RNAi 0 Yes MybdsRNA.cRa in vitro construct - RNAi 0 Yes MybGMR.PO in vitro construct - regulatory fusion 0 Yes MybKK100767 in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes MybMtnA.C.T:Avic\GFP in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes MybMtnA.N.T:Avic\GFP in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes MybScer\UAS.cDa in vitro construct - regulatory fusion 0 Yes MybScer\UAS.cFa in vitro construct - regulatory fusion 0 Yes MybScer\UAS.cMa in vitro construct - regulatory fusion 0 Yes MybScer\UAS.N.T:Avic\GFP-EGFP in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes MybScer\UAS.N.T:Disc\RFP in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes MybScer\UAS.T:Avic\GFP-EGFP in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes MybScer\UAS.T:Hsap\MYC in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes Mybt9.8 in vitro construct - genomic fragment 0 Yes MybΔ.Scer\UAS.T:Hsap\MYC in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes MybΔ.Scer\UAS in vitro construct - regulatory fusion 0 Yes MybΔ239-657.Act5C in vitro construct - deletion 0 Yes MybΔ316-657.Act5C in vitro construct - deletion 0 Yes MybΔ411-499.Act5C in vitro construct - deletion 0 Yes MybΔ416-657.Act5C in vitro construct - deletion 0 Yes MybΔ519-531.Act5C in vitro construct - deletion 0 Yes MybΔ531-657.Act5C in vitro construct - deletion 0 Yes MybΔC.GMR in vitro construct - deletion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(1)EM43 (Katzen, 1990) Df(1)Exel6251 (Ryder, 2004.4.26) Df(1)sd72b (Katzen et al., 1998, Katzen, 1990, Katzen and Bishop, 1996)
Duplicated in	Dp(1;4)r+l (Katzen, 1990) Dp(1;Y)shi+1 (Katzen, 1990, Katzen and Bishop, 1996)
Not disrupted in	Df(1)19 (Katzen, 1990, Katzen and Bishop, 1996) Dp(1;4)r+m (Katzen and Bishop, 1996) Dp(1;4)r+s (Katzen and Bishop, 1996)
Not duplicated in	Dp(1;4)r+m (Katzen, 1990) Dp(1;4)r+s (Katzen, 1990)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD4472} NA P{KK100767} NA P{TRiP.HMS01467} NA P{TRiP.JF02135} NA P{UAS-EGFP-Myb} NA P{UAS-Myb.D} NA P{UAS-Myb.F} NA P{UAS-Myb.GFP} NA P{UAS-Myb.M} NA P{UAS-Myb.MYC} NA P{UAS-Myb.Δ.MYC} NA P{UAS-Myb.Δ} NA P{UAS-RFP-Myb} NA characterization construct P{9.0-K/S} NA P{11.6-(3')-S/S} NA P{15-X/S} NA P{GMR-Myb.O} NA P{GMR-Myb.ΔC} NA P{Myb.13X} NA P{Myb+6.7} NA P{Myb+,AlkB-.6.6} NA P{Myb-,AlkB+.9.8} NA P{MybFS6.7} NA P{Myb-GFP.M} NA P{UAS-EGFP-Myb.Cterm} NA
Insertions
	Type of insertions Name Expression data insertion of mobile activating element P{EP}MybG233 NA
Gene Ontology: Function, Process & Cellular Component ( 20 unique terms )
Terms Based on Experimental Evidence ( 18 terms )
Molecular Function
CV term Evidence References
DNA binding inferred from direct assay (Beall et al., 2002)
Biological Process
CV term Evidence References
cell cycle inferred from genetic interaction with cdc2 (Okada et al., 2002) inferred from genetic interaction with CycB (Okada et al., 2002) inferred from genetic interaction with nej (Okada et al., 2002) inferred from genetic interaction with stg (Okada et al., 2002) inferred from mutant phenotype (Okada et al., 2002) cell proliferation inferred from mutant phenotype (Fung et al., 2002) centriole replication inferred from mutant phenotype (Dobbelaere et al., 2008) centrosome cycle inferred from mutant phenotype (Fung et al., 2002) centrosome organization inferred from mutant phenotype (Goshima et al., 2007) chromosome condensation inferred from mutant phenotype (Manak et al., 2007) cytokinesis inferred from mutant phenotype (Manak et al., 2002) eggshell chorion gene amplification inferred from mutant phenotype (Beall et al., 2002) mitosis inferred from mutant phenotype (Manak et al., 2002, Goshima et al., 2007) mitotic cell cycle inferred from direct assay (Wen et al., 2008) mitotic spindle organization inferred from mutant phenotype (Goshima et al., 2007) regulation of mitosis inferred from direct assay (Wen et al., 2008) inferred from genetic interaction with nej (Fung et al., 2003) inferred from mutant phenotype (Fung et al., 2003) regulation of transcription, DNA-dependent inferred from direct assay (Okada et al., 2002) spindle organization inferred from mutant phenotype (Manak et al., 2002)
Cellular Component
CV term Evidence References
Myb complex inferred from direct assay (Beall et al., 2002, Lewis et al., 2004, Korenjak et al., 2004) nuclear euchromatin inferred from direct assay (Manak et al., 2007, Scaria et al., 2008) polytene chromosome inferred from direct assay (Beall et al., 2007)
Terms Based on Predictions or Assertions ( 5 terms )
Molecular Function
CV term Evidence References
DNA binding inferred from sequence or structural similarity with UniProtKB:P01103 (FlyBase, 1992-) non-traceable author statement (Swiss-Prot Project Members, 1987.3.20) sequence-specific DNA binding transcription factor activity traceable author statement (Lee and Orr-Weaver, 2003)
Biological Process
CV term Evidence References
eggshell chorion gene amplification traceable author statement (Lee and Orr-Weaver, 2003) regulation of transcription, DNA-dependent inferred from sequence or structural similarity with UniProtKB:P01103 (FlyBase, 1992-)
Cellular Component
CV term Evidence References
nucleus inferred from sequence or structural similarity with UniProtKB:P01103 (FlyBase, 1992-) non-traceable author statement (Swiss-Prot Project Members, 1987.3.20)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Myb allele Gene References Myb1 nej (Fung et al., 2003) Myb2 cdc2 (Katzen et al., 1998) nej (Fung et al., 2003) stg (Katzen et al., 1998) Mybel2507 bon (Nomura et al., 2004) MybMH107 mip130 (Beall et al., 2004) MybΔ.Scer\UAS E2f (Fitzpatrick et al., 2002) MybΔC.GMR cdc2 (Okada et al., 2002) CycB (Okada et al., 2002) nej (Okada et al., 2002) stg (Okada et al., 2002)
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 58891 DroID - A comprehensive database of gene and protein interactions. • FBgn0002914 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 32543
Orthologs
Genome-wide drosophilid orthologs	Dana\GF19984 Dere\GG19364 Dgri\GH11855 Dper\GL24710 Dpse\GA21500 Dsec\GM22518 Dsim\GD24674 Dvir\GJ18431 Dwil\GK16252 Dyak\GE16012
Curated drosophilid orthologs	Dpse\GA21500
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL014286-PA Aedes aegypti (mosquito) AGAP008160-PA Anopheles gambiae (mosquito) XP_393231.3 Apis mellifera (honey bee) XP_001949674.1 Acyrthosiphon pisum (pea aphid) 123541 Branchiostoma floridae (lancelet) BGIBMGA013826-PA Bombyx mori (silk worm) ENSBTAP00000044253 Bos taurus (bovine) ENSCAFP00000000330 Canis familiaris (dog) CPIJ004862 Culex pipens (mosquito) ENSCPOP00000013161 Cavia porcellus (guinea pig) DDB0219992 Dictyostelium discoideum (amoeba) ENSDARP00000066654 Danio rerio (zebra fish) ENSECAP00000008584 Equus caballus (horse) ENSGACP00000003879 Gymnopilus aculeatus (mushroom) ENSGALP00000024981 Gallus gallus (chicken) 194177 Hypsipyla robusta (cedar shoot borer) ENSP00000339992 Homo sapiens (human) ISCW012531-PA Ixodes scapularis (deer tick) KLLA0F10978g Kluyveromyces lactis (yeast) ENSMODP00000021821 Monodelphis domestica (gray opossum) ENSMMUP00000023903 Macaca mulatta (rhesus monkey) ENSMUSP00000020156 Mus musculus (house mouse) XP_001600125.1 Nasonia vitripennis (wasp) ENSOANP00000004421 Ornithorynchus anatinus (platypus) ENSORLP00000010660 Oryzias latipes (japanese killifish) LOC_Os01g74590.1 Oryza sativa (asian rice) ENSPPYP00000020912 Pongo pygmaeus (orangutan) ENSPTRP00000031801 Pan troglodytes (chimpanzee) ENSRNOP00000019299 Rattus norvegicus (norway rat) YKR099W Saccharomyces cerevisiae (budding yeast) ENSTNIP00000013002 Tetraodon nigroviridis (green spotted pufferfish) ENSTRUP00000022155 Takifugu rubripes (pufferfish Takifugu) 3822.m00639 Tetrahymena thermophila (ciliate protozoa) ENSXETP00000008057 Xenopus tropicalis (frog) YALI0B13992g Yarrowia lipolytica (nonconventional yeast) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • NV17529 LH13898 ISCW012531 FBgn0233564 FBgn0218254 FBgn0205590 FBgn0196001 FBgn0177388 JGI_V11_6813 FBgn0081486 FBgn0162298 FBgn0119334 FBgn0111568 FBgn0096991 CPIJ004862 BGIBMGA013827 BGIBMGA013826 ACYPI008532 ACYPI005393 GB12498 AGAP008160 AAEL014286 PB22704 PHUM518530 GLEAN_10032
Stocks & Reagents
Stocks Listed in FlyBase ( 8 )
Bloomington	32044 w1118; P{Myb-GFP.M}A9 26237 y1 v1; P{TRiP.JF02135}attP2 33447 w* P{EP}MybG233/FM6, w1 35053 y1 sc* v1; P{TRiP.HMS01467}attP2
Kyoto	109167 w* Mybel1 / FM7c 109168 w* Mybel2507 / FM7c
VDRC	v37710 w1118; P{GD4472}v37710 v37711 w1118; P{GD4472}v37711
Genomic Clones ( 2 )
	BACR22H11 BACR25C18 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 170 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	LD22943
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	AT04548 AT07314 AT08126 AT09455 AT12268 AT16212 GH11890 LD02949 LD05095 LD13256 LD14184 LD16659 LD22905 LD28002 LD28014 LD28062 LD29852 LD33366 LD47833 LP16776 RE10282 RE14239 RE15271 RE17289 RE21911 RE22346 RE23834 RE28074 RE28129 RE29509 RE36875 RE38819 RE41326 RE43424 RE48245 RE49446 RE51346 RE54095 RE54212 RE56257 RE58030 RE60356 RE60673 RE61880 RE64231 RE64362 RE65381 RE65813 RE67891 RE73053 RH22539 RH31129 RH37426 RH56652 SD02133 SD09130 SD17606 SD18118
Other clones	14693 33213 40231 54462 66331 83692 97006 101540 102073 104422 107836 147736 162736 CK01.66D.G12 CK01.114C.D11 Dmel_neb_010553_0375_0608 Dmel_neb_011770_0330_3570 Dmel_neb_015487_0443_2750 EC35209 EK053103 EK053960 EK143611 EK153964 EK164727 EK179325 EK194231 EK217862 EK227945 EK234228 EK244737 FGC029H11 FGH113C03 IP02455 RP003009264 RP003012846 RP003014186 RP003029360 RP003032527 RP003055511 RP003059517 RP003074928 RP003076440 RP003105637 RP003113569 RP003123379 RP003125824 RP003126805 RP003151694 RP003165636 RP003165811 RP003177478 RP003178855 RP003192963 RP003194717 RP003197457 RP003198040 RP003202028 RP003202104 RP003204877 RP003229423 RP003240733 RP003244578 RP003260280 RP003264589 RP003267540 RP003267831 RP003273888 RP003275804 RP003281994 RP003282682 RP003289173 RP003294430 RP003295729 RP003300596 RP003306374 RP003311695 RP003314130 RP003314462 RP003315300 RP003317924 RP003326367 RP003330589 RP003342258 RP003342538 RP003344466 RP003353773 RP003354794 RP003358625 RP003361971 RP003380404 RP003399344 RP003477048 RP003487349 RP003489483 RP003516259 RP003518456 RP003518459 RP003520675 RP003540529 RP003560614 RP003568149 RP003589979 RP003593780 RP003604651 RP003643654 RP003645075 RP003646049 RP003656368 RP003660925 RP003666063 RP003681776
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0002914 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 32543
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: Myb CG9045 (Gong, 1999.11)
Source for database merge of
Additional comments
Other Comments
	Myb is involved in centriole duplication and is required for efficient recruitment of pericentriolar material. (Dobbelaere et al., 2008) Loss of Myb causes mitotic delay with spindle pole abnormalities. (Wen et al., 2008) RNAi screen using dsRNA made from templates generated with primers directed against this gene results in the formation of monastral bipolar, long spindles, detachment of the spindle pole and few mitoses when assayed in S2 cells. This phenotype can be observed when the screen is performed with or without Cdc27 dsRNA. (Goshima et al., 2007) RNAi screen using dsRNA made from templates generated with primers directed against this gene in S2 cells results in the formation of normal bipolar or occasionally multipolar spindles. Subsequently one or more of the centrosomes detech from the spindle poles and wonder toward the center of the cell. In some instances, centrosomes fuse, resulting in a monastral bipolar spindle. (Goshima et al., 2007) nej and Myb work together to promote efficient progression through mitosis. (Fung et al., 2003) In abdominal epidermal cell, Myb is required to sustain the appropriate rate of proliferation, to suppress formation of supernumerary centrosomes, and to maintain genomic integrity. (Fung et al., 2002) Myb induces expression of CycB in the eye imaginal disc. (Okada et al., 2002) Myb regulates the G2/M transition by inducing CycB expression via binding to AACNG sequences in its promoter. (Okada et al., 2002) Mutant wing cells fail to complete the final mitosis in their developmental lineage and a subset of nuclei enter endoreplication cycles. The failure of mutant wing cells to complete the final cell division cycle is likely to be an immediate consequence of the deficiency in Myb function. (Katzen et al., 1998) Myb is required for both mitosis and prevention of endoreplication in wing cells. Myb acts at or near the time of the G2/M transition. (Katzen et al., 1998) A series of phylogenetic analyses is performed to explore the interrelationships among 42 Myb proteins from both plants and animals - a test of the null hypothesis 'Myb proteins are a homogeneous, monophyletic, evolutionary lineage'. (Rosinski and Atchley, 1998) Using the co-transfection assay with the nej expression plasmid results demonstrate trans-activation by Myb and functional domains of Myb involved in this activity are identified. (Hou et al., 1997) There is a quasihydrophobic site on the protein to which the hydrophobic probe TNS (6-p-Toluidino-2-naphthalenesulfonate) binds. This binding site is found within the vicinity of Tyr and several Trp residues. (Madan et al., 1994) The DNA binding domain of Myb has been overexpressed in E.coli, purified, and subjected to 2D and 3D NMR experiments. (Radha et al., 1994) Myb is an essential gene whose function is important during most stages of development. Aspects of the mutant phenotype implicate Myb in the control of cell division. (Katzen, 1990) Myb has been cloned and sequenced. It contains two regions of homology to vertebrate myb proteins. DNA-binding experiments show that the amino-terminal proximal region of homology functions as a DNA binding domain. (Peters et al., 1987) Considered to be the Drosophila homologue of avian c-myb. Open reading frame identified to date encodes a polypeptide exhibiting 73% homology with chicken c-myb protein.
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_078615 NM_206731 NM_206732 NM_206733 NM_206734 RefSeq (Proteins) • NP_511170 NP_996454 NP_996455 NP_996456 NP_996457 DDBJ / EMBL / GenBank • AA817467 AAA70367 AAF48529 AAO25019 AAS65355 AAS65356 AAS65357 AAS65358 BT003262 CAA29373 M11281 X05939 Entrez Gene - A searchable database of RefSeq genes. • 32543 UniProtKB/Swiss-Prot • P04197 UniProtKB/TrEMBL • Q53YG3
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • SANT domain, DNA binding (IPR001005) Homeodomain-like (IPR009057) Homeodomain-related (IPR012287) Myb, DNA-binding (IPR014778) C-myb, C-terminal (IPR015395) Myb transcription factor (IPR015495) MYB-like (IPR017877) Transcription regulator HTH, Myb-type, DNA-binding (IPR017930)
Linkouts
	BioGRID - A database of protein and genetic interactions • 58891 DroID - A comprehensive database of gene and protein interactions. • FBgn0002914 DRSC - Results from RNAi screens. • FBgn0002914 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0002914 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG9045-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0002914 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 32543 InParanoid A subset of ortholog calls from InParanoid. • AAEL014286-PA Aedes aegypti (mosquito) AGAP008160-PA Anopheles gambiae (mosquito) XP_393231.3 Apis mellifera (honey bee) XP_001949674.1 Acyrthosiphon pisum (pea aphid) 123541 Branchiostoma floridae (lancelet) BGIBMGA013826-PA Bombyx mori (silk worm) ENSBTAP00000044253 Bos taurus (bovine) ENSCAFP00000000330 Canis familiaris (dog) CPIJ004862 Culex pipens (mosquito) ENSCPOP00000013161 Cavia porcellus (guinea pig) DDB0219992 Dictyostelium discoideum (amoeba) ENSDARP00000066654 Danio rerio (zebra fish) ENSECAP00000008584 Equus caballus (horse) ENSGACP00000003879 Gymnopilus aculeatus (mushroom) ENSGALP00000024981 Gallus gallus (chicken) 194177 Hypsipyla robusta (cedar shoot borer) ENSP00000339992 Homo sapiens (human) ISCW012531-PA Ixodes scapularis (deer tick) KLLA0F10978g Kluyveromyces lactis (yeast) ENSMODP00000021821 Monodelphis domestica (gray opossum) ENSMMUP00000023903 Macaca mulatta (rhesus monkey) ENSMUSP00000020156 Mus musculus (house mouse) XP_001600125.1 Nasonia vitripennis (wasp) ENSOANP00000004421 Ornithorynchus anatinus (platypus) ENSORLP00000010660 Oryzias latipes (japanese killifish) LOC_Os01g74590.1 Oryza sativa (asian rice) ENSPPYP00000020912 Pongo pygmaeus (orangutan) ENSPTRP00000031801 Pan troglodytes (chimpanzee) ENSRNOP00000019299 Rattus norvegicus (norway rat) YKR099W Saccharomyces cerevisiae (budding yeast) ENSTNIP00000013002 Tetraodon nigroviridis (green spotted pufferfish) ENSTRUP00000022155 Takifugu rubripes (pufferfish Takifugu) 3822.m00639 Tetrahymena thermophila (ciliate protozoa) ENSXETP00000008057 Xenopus tropicalis (frog) YALI0B13992g Yarrowia lipolytica (nonconventional yeast) Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution • /newgene/myb1.htm InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 32543 modMine - Data generated by the modENCODE project. • FBgn0002914 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • NV17529 LH13898 ISCW012531 FBgn0233564 FBgn0218254 FBgn0205590 FBgn0196001 FBgn0177388 JGI_V11_6813 FBgn0081486 FBgn0162298 FBgn0119334 FBgn0111568 FBgn0096991 CPIJ004862 BGIBMGA013827 BGIBMGA013826 ACYPI008532 ACYPI005393 GB12498 AGAP008160 AAEL014286 PB22704 PHUM518530 GLEAN_10032 REDfly - A database of transcriptional regulatory elements. • FBgn0002914
Synonyms & Secondary IDs ( 21 )
Reported As
Symbol Synonym	CG9045 (Ramet et al., 2002, Brody et al., 2002, Lipsick, 2000.9.11, Goshima et al., 2007, Beall et al., 2007, Dobbelaere et al., 2008, Perkins et al., 2009.3.31, Casola et al., 2007, Keleman et al., 2009.8.5, Ni et al., 2011.7.19) c-Myb (Bhaskar and Courey, 2002, Rosinski and Atchley, 1998, Radha et al., 1995, Mourikis et al., 2010) c-myb (Madan et al., 1994, Katzen, 1990) Dm-Myb (Davidson et al., 2005, Davidson et al., 2003, Manak et al., 2003, Manak et al., 2002, Davidson and Lipsick, 2002, Manak et al., 2001, Manak et al., 2001, Madan et al., 1995, Madan et al., 1995, Manak et al., 2007) DmMyb (Beall et al., 2004, Manak et al., 2007) Dm myb (Scaria et al., 2004, Katzen et al., 2004, Sharkov et al., 2002, Fitzpatrick et al., 2002, Katzen et al., 2001, Fitzpatrick et al., 2000, Katzen et al., 1999, Katzen et al., 1998, McEllin et al., 2006) dmMYB (Mohrmann et al., 2002) Dm-myb (Scaria et al., 2003, Madan et al., 1994) Dm Myb (Manak et al., 2000) DmMYB (Martin and Paz-Ares, 1997) dMyb (Korenjak and Brehm, 2005, Korenjak et al., 2004, Okada et al., 2002) dmyb (Nomura et al., 2004, Brun et al., 2006) DMyb (Fitzpatrick et al., 2003, Rovani et al., 2006, Rovani et al., 2008) D-myb (Vingron, 1987.9.24, Hou et al., 1997, Pribyl et al., 1988, Peters et al., 1987) Dmyb (Scaria et al., 2008) l(1)XVI   MYB (Lee and Orr-Weaver, 2003) myb (Scaria et al., 2004, Ren et al., 2004, Fung et al., 2003, Orian et al., 2003, Fung et al., 2002, Katzen et al., 2002, Fung et al., 2002, Fitzpatrick et al., 2001, Richards et al., 2001, Fung et al., 2000, Potter et al., 2000, Katzen et al., 1998, Walch et al., 1997, Katzen et al., 1997, Katzen and Bishop, 1996, van der Bliek and Meyerowitz, 1991, Beall et al., 2007, Hyun et al., 2005, Scaria et al., 2008) Myb (Goshima et al., 2007, Lipsick et al., 2007, Kohzaki and Murakami, 2005, Doggett et al., 2007, Garcia et al., 2007, Goshima et al., 2007, Wen et al., 2008, Beall et al., 2007, Georlette et al., 2007, Somma et al., 2008, Dobbelaere et al., 2008, Manak et al., 2007, Wen et al., 2008, Weake et al., 2011, Dworkin et al., 2009, Chew et al., 2009, Bin and Lipsick, 1993) p85 (Beall et al., 2002)
Name Synonym	Myb oncogene-like
Secondary FlyBase IDs
References ( 122 )
Generate a list of	All references relating to this gene ( 122 )
List References by type	Research paper  ( 53 ) Supplementary material  ( 5 ) Review  ( 11 ) Personal communication to FlyBase  ( 7 ) Abstract  ( 34 ) FlyBase analysis  ( 1 ) DNA/RNA sequence record  ( 1 ) Thesis  ( 1 ) Conference report  ( 1 ) Curated genome annotation  ( 2 ) Protein sequence record  ( 1 ) Computer file  ( 2 ) Automatic genome annotation  ( 1 ) Book  ( 1 )
Recent research papers ( 2 )
	Weake et al., 2011, Genes Dev. 25(14): 1499--1509 Post-transcription initiation function of the ubiquitous SAGA complex in tissue-specific gene activation. [FBrf0214372] Mourikis et al., 2010, BMC Dev. Biol. 10: 107 Modifiers of notch transcriptional activity identified by genome-wide RNAi. [FBrf0212287] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2010 Show reviews ...