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General Information
Symbol
Dmel\Myb
Species
D. melanogaster
Name
Myb oncogene-like
Annotation Symbol
CG9045
Feature Type
FlyBase ID
FBgn0002914
Gene Model Status
Stock Availability
Gene Snapshot
Myb oncogene-like (Myb) encodes a transcription factor that activates the transcription of genes involved in the G2/M phases of the cell cycle. This activation occurs by inhibition of the highly conseved MuvB multi-protein repressor complex. [Date last reviewed: 2019-03-14]
Also Known As
Dm-Myb, Dm myb, dMyb, D-myb, c-Myb
Key Links
Genomic Location
Cytogenetic map
Sequence location
X:15,854,832..15,857,823 [-]
Recombination map
1-52
Sequence
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
Function
GO Summary Ribbons
Protein Family (UniProt)
-
Summaries
Gene Group (FlyBase)
SANT-MYB DOMAIN TRANSCRIPTION FACTORS -
The SANT-MYB domain transcription factors are sequence specific DNA-binding proteins that regulate transcription. The Myb domain is a DNA binding helix-turn-helix domain that contains three tandem repeats of 50 amino acids, termed R1, R2 and R3. The α-helical repeats R2 and R3 are involved in the DNA interaction. (Adapted from PMID:10378697).
Protein Function (UniProtKB)
DNA-binding protein that specifically recognizes the sequence 5'-YAAC[GT]G-3'. Component of the DREAM complex, a multiprotein complex that can both act as a transcription activator or repressor depending on the context. In follicle cells, the complex plays a central role in the site-specific DNA replication at the chorion loci. During development, the complex represses transcription of developmentally controlled E2F target genes.
(UniProt, P04197)
Phenotypic Description (Red Book; Lindsley and Zimm 1992)
Myb: Myb proto-oncongene sequence
Considered to be the Drosophila homologue of avian c-myb. Open reading frame identified to date encodes a polypeptide exhibiting 73% homology with chicken c-myb protein.
Summary (Interactive Fly)
transcription factor - Myb DNA-binding domain - required for mitosis and prevention of endoreduplication in wing cells - activates the transcription of genes involved in the G2/M phases of the cell cycle by inhibition of the highly conserved MuvB multi-protein repressor complex.
Gene Model and Products
Number of Transcripts
4
Number of Unique Polypeptides
1

Please see the GBrowse view of Dmel\Myb or the JBrowse view of Dmel\Myb for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model
Gene model reviewed during 6.01
Gene model reviewed during 5.50
Annotated transcripts do not represent all supported alternative splices within 5' UTR.
Low-frequency RNA-Seq exon junction(s) not annotated.
Annotated transcripts do not represent all possible combinations of alternative exons and/or alternative promoters.
Gene model reviewed during 5.55
gene_with_dicistronic_mRNA ; SO:0000722
Gene model reviewed during 6.29
Sequence Ontology: Class of Gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
FBtr0074169
2808
657
FBtr0074170
2732
657
FBtr0074171
2865
657
FBtr0074173
2903
657
Additional Transcript Data and Comments
Reported size (kB)
3.2 (northern blot)
2.814 (longest cDNA)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
FBpp0073961
74.0
657
9.20
FBpp0089402
74.0
657
9.20
FBpp0089403
74.0
657
9.20
FBpp0089405
74.0
657
9.20
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

657 aa isoforms: Myb-PA, Myb-PB, Myb-PD, Myb-PE
Additional Polypeptide Data and Comments
Reported size (kDa)
657 (aa); 74 (kD predicted)
Comments
External Data
Subunit Structure (UniProtKB)
Component of the DREAM complex at least composed of Myb, Caf1, mip40, mip120, mip130, E2f2, Dp, Rbf, Rbf2, lin-52, Rpd3 and l(3)mbt.
(UniProt, P04197)
Crossreferences
Linkouts
Sequences Consistent with the Gene Model
Nucleotide / Polypeptide Records
 
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Myb using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Gene Ontology (23 terms)
Molecular Function (3 terms)
Terms Based on Experimental Evidence (2 terms)
CV Term
Evidence
References
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
Biological Process (16 terms)
Terms Based on Experimental Evidence (15 terms)
CV Term
Evidence
References
inferred from mutant phenotype
inferred from mutant phenotype
inferred from mutant phenotype
inferred from mutant phenotype
inferred from mutant phenotype
inferred from direct assay
inferred from mutant phenotype
inferred from direct assay
inferred from mutant phenotype
inferred from genetic interaction with FLYBASE:nej; FB:FBgn0261617
inferred from mutant phenotype
Terms Based on Predictions or Assertions (3 terms)
CV Term
Evidence
References
inferred from biological aspect of ancestor with PANTHER:PTN000067791
(assigned by GO_Central )
inferred from biological aspect of ancestor with PANTHER:PTN000067791
(assigned by GO_Central )
Cellular Component (4 terms)
Terms Based on Experimental Evidence (4 terms)
CV Term
Evidence
References
Terms Based on Predictions or Assertions (0 terms)
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
organism

Comment: maternally deposited

radioisotope in situ
Stage
Tissue/Position (including subcellular localization)
Reference
RT-PCR
Stage
Tissue/Position (including subcellular localization)
Reference
Additional Descriptive Data
The 3.2 kb Myb transcript is detected throughout development. Myb transcript is detected mainly in proliferating tissues, though expression is seen at lower levels in some post-mitotic tissues. Expression is uniform and high in preblastoderm embryos, and continues to be high during cellular blastoderm formation and germ band extension. Message is less uniform in contracted germ band embryos, with no expression seen in the amnioserosa, and low expression in the salivary glands. Later in embryogenesis, Myb transcript is high only in the CNS. In climbing third instar larvae, tissues contributing to the adult express Myb at high levels: imaginal disc, brain, ventral ganglion, testes, ovaries, and nests of imaginal cells in the gut. Expression in these tissues continues in the early pupa, with additional expression detected in histoblasts and epithelial cells of the developing imaginal gut. Myb levels decline in everted imaginal tissues. Ovary, testis, and neural tissue continue to express Myb transcript through pupal development. Myb is detected at low levels in the brain and thoracic ganglia of adults, and expression is high in adult testes and ovaries.
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
immunolocalization
Stage
Tissue/Position (including subcellular localization)
Reference
western blot
Stage
Tissue/Position (including subcellular localization)
Reference
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\Myb in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
Alleles, Insertions, and Transgenic Constructs
Classical and Insertion Alleles ( 9 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 59 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of Myb
Transgenic constructs containing regulatory region of Myb
Deletions and Duplications ( 8 )
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
Other Phenotypes
Allele
Phenotype manifest in
Allele
hemocyte & nucleus
macrochaeta & wing | maternal effect
microchaeta & adult abdomen
microchaeta & wing | maternal effect
mitosis & nuclear chromosome
mitosis & nuclear chromosome (with Df(1)sd72a)
wing & cell
wing & macrochaeta
wing & nucleus
Orthologs
Human Orthologs (via DIOPT v7.1)
Homo sapiens (Human) (5)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Alignment
Complementation?
Transgene?
12 of 15
Yes
Yes
12 of 15
Yes
Yes
10 of 15
No
Yes
2 of 15
No
No
1 of 15
No
Yes
Model Organism Orthologs (via DIOPT v7.1)
Mus musculus (laboratory mouse) (6)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Alignment
Complementation?
Transgene?
12 of 15
Yes
Yes
12 of 15
Yes
Yes
9 of 15
No
Yes
2 of 15
No
Yes
2 of 15
No
No
1 of 15
No
Yes
Rattus norvegicus (Norway rat) (3)
10 of 13
Yes
Yes
7 of 13
No
Yes
Xenopus tropicalis (Western clawed frog) (3)
6 of 12
Yes
Yes
6 of 12
Yes
Yes
1 of 12
No
Yes
Danio rerio (Zebrafish) (6)
11 of 15
Yes
Yes
11 of 15
Yes
Yes
6 of 15
No
Yes
4 of 15
No
Yes
1 of 15
No
Yes
1 of 15
No
No
Caenorhabditis elegans (Nematode, roundworm) (1)
2 of 15
Yes
No
Arabidopsis thaliana (thale-cress) (124)
5 of 9
Yes
Yes
5 of 9
Yes
Yes
4 of 9
No
Yes
4 of 9
No
Yes
3 of 9
No
Yes
2 of 9
No
Yes
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No
Yes
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No
Yes
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Yes
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Yes
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No
Yes
1 of 9
No
Yes
1 of 9
No
Yes
1 of 9
No
Yes
1 of 9
No
Yes
1 of 9
No
Yes
Saccharomyces cerevisiae (Brewer's yeast) (3)
8 of 15
Yes
Yes
1 of 15
No
Yes
1 of 15
No
Yes
Schizosaccharomyces pombe (Fission yeast) (3)
1 of 12
Yes
No
1 of 12
Yes
Yes
1 of 12
Yes
Yes
Orthologs in Drosophila Species (via OrthoDB v9.1) ( EOG09190416 )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila melanogaster
fruit fly
Drosophila suzukii
Spotted wing Drosophila
Drosophila simulans
Drosophila sechellia
Drosophila erecta
Drosophila yakuba
Drosophila ananassae
Drosophila pseudoobscura pseudoobscura
Drosophila persimilis
Drosophila willistoni
Drosophila virilis
Drosophila mojavensis
Drosophila grimshawi
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG0915021I )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Glossina morsitans
Tsetse fly
Lucilia cuprina
Australian sheep blowfly
Mayetiola destructor
Hessian fly
Aedes aegypti
Yellow fever mosquito
Anopheles darlingi
American malaria mosquito
Anopheles gambiae
Malaria mosquito
Culex quinquefasciatus
Southern house mosquito
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W01TT )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Bombyx mori
Silkmoth
Bombyx mori
Silkmoth
Danaus plexippus
Monarch butterfly
Heliconius melpomene
Postman butterfly
Apis florea
Little honeybee
Apis mellifera
Western honey bee
Bombus impatiens
Common eastern bumble bee
Bombus terrestris
Buff-tailed bumblebee
Linepithema humile
Argentine ant
Megachile rotundata
Alfalfa leafcutting bee
Nasonia vitripennis
Parasitic wasp
Dendroctonus ponderosae
Mountain pine beetle
Tribolium castaneum
Red flour beetle
Pediculus humanus
Human body louse
Cimex lectularius
Bed bug
Acyrthosiphon pisum
Pea aphid
Zootermopsis nevadensis
Nevada dampwood termite
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X01RI )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strigamia maritima
European centipede
Ixodes scapularis
Black-legged tick
Stegodyphus mimosarum
African social velvet spider
Tetranychus urticae
Two-spotted spider mite
Tetranychus urticae
Two-spotted spider mite
Daphnia pulex
Water flea
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( None identified )
No non-Arthropod Metazoa orthologies identified
Paralogs
Paralogs (via DIOPT v7.1)
Drosophila melanogaster (Fruit fly) (1)
3 of 10
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Model Summary Ribbon
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 0 )
    Human Ortholog
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Interaction
    References
    Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
     
    Disease Associations of Human Orthologs (via DIOPT v7.1 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    Functional Complementation Data
    Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
    Interactions
    Summary of Physical Interactions
    esyN Network Diagram
    Show neighbor-neighbor interactions:
    Select Layout:
    Legend:
    Protein
    RNA
    Selected Interactor(s)
    Interactions Browser

    Please see the Physical Interaction reports below for full details
    protein-protein
    Physical Interaction
    Assay
    References
    Summary of Genetic Interactions
    esyN Network Diagram
    esyN Network Key:
    Suppression
    Enhancement

    Please look at the allele data for full details of the genetic interactions
    Starting gene(s)
    Interaction type
    Interacting gene(s)
    Reference
    Starting gene(s)
    Interaction type
    Interacting gene(s)
    Reference
    External Data
    Subunit Structure (UniProtKB)
    Component of the DREAM complex at least composed of Myb, Caf1, mip40, mip120, mip130, E2f2, Dp, Rbf, Rbf2, lin-52, Rpd3 and l(3)mbt.
    (UniProt, P04197 )
    Linkouts
    BioGRID - A database of protein and genetic interactions.
    DroID - A comprehensive database of gene and protein interactions.
    InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
    MIST (genetic) - An integrated Molecular Interaction Database
    MIST (protein-protein) - An integrated Molecular Interaction Database
    Pathways
    Gene Group - Pathway Membership (FlyBase)
    External Data
    Linkouts
    SignaLink - A signaling pathway resource with multi-layered regulatory networks.
    Genomic Location and Detailed Mapping Data
    Chromosome (arm)
    X
    Recombination map
    1-52
    Cytogenetic map
    Sequence location
    X:15,854,832..15,857,823 [-]
    FlyBase Computed Cytological Location
    Cytogenetic map
    Evidence for location
    13F14-13F14
    Limits computationally determined from genome sequence between P{EP}BEST:RE35685EP1581&P{EP}sdEP1088 and P{EP}Gβ13FEP1071
    Experimentally Determined Cytological Location
    Cytogenetic map
    Notes
    References
    13E-13F
    (determined by in situ hybridisation)
    13F-13F
    (determined by in situ hybridisation)
    Experimentally Determined Recombination Data
    Location
    Left of (cM)
    Right of (cM)
    Notes
    Stocks and Reagents
    Stocks (18)
    Genomic Clones (18)
     

    Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

    cDNA Clones (170)
     

    Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

    cDNA clones, fully sequences
    BDGP DGC clones
    Other clones
      Drosophila Genomics Resource Center cDNA clones

      For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

      cDNA Clones, End Sequenced (ESTs)
      RNAi and Array Information
      Linkouts
      DRSC - Results frm RNAi screens
      GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
      Antibody Information
      Laboratory Generated Antibodies
       
      polyclonal
      Commercially Available Antibodies
       
      Other Information
      Relationship to Other Genes
      Source for database identify of
      Source for identity of: Myb CG9045
      Source for database merge of
      Additional comments
      One or more of the processed transcripts for this gene contain(s) two non-overlapping open reading frames (ORFs). The non-overlapping ORFs are represented by Myb and CG46440.
      Other Comments
      Duplicate transcripts identified and eliminated during the migration of annotations from the release 5 genome assembly to the release 6 assembly.
      Myb is involved in centriole duplication and is required for efficient recruitment of pericentriolar material.
      Loss of Myb causes mitotic delay with spindle pole abnormalities.
      RNAi screen using dsRNA made from templates generated with primers directed against this gene results in the formation of monastral bipolar, long spindles, detachment of the spindle pole and few mitoses when assayed in S2 cells. This phenotype can be observed when the screen is performed with or without Cdc27 dsRNA.
      RNAi screen using dsRNA made from templates generated with primers directed against this gene in S2 cells results in the formation of normal bipolar or occasionally multipolar spindles. Subsequently one or more of the centrosomes detech from the spindle poles and wonder toward the center of the cell. In some instances, centrosomes fuse, resulting in a monastral bipolar spindle.
      nej and Myb work together to promote efficient progression through mitosis.
      In abdominal epidermal cell, Myb is required to sustain the appropriate rate of proliferation, to suppress formation of supernumerary centrosomes, and to maintain genomic integrity.
      Myb induces expression of CycB in the eye imaginal disc.
      Myb regulates the G2/M transition by inducing CycB expression via binding to AACNG sequences in its promoter.
      Mutant wing cells fail to complete the final mitosis in their developmental lineage and a subset of nuclei enter endoreplication cycles. The failure of mutant wing cells to complete the final cell division cycle is likely to be an immediate consequence of the deficiency in Myb function.
      Myb is required for both mitosis and prevention of endoreplication in wing cells. Myb acts at or near the time of the G2/M transition.
      A series of phylogenetic analyses is performed to explore the interrelationships among 42 Myb proteins from both plants and animals - a test of the null hypothesis 'Myb proteins are a homogeneous, monophyletic, evolutionary lineage'.
      Using the co-transfection assay with the nej expression plasmid results demonstrate trans-activation by Myb and functional domains of Myb involved in this activity are identified.
      There is a quasihydrophobic site on the protein to which the hydrophobic probe TNS (6-p-Toluidino-2-naphthalenesulfonate) binds. This binding site is found within the vicinity of Tyr and several Trp residues.
      The DNA binding domain of Myb has been overexpressed in E.coli, purified, and subjected to 2D and 3D NMR experiments.
      Myb is an essential gene whose function is important during most stages of development. Aspects of the mutant phenotype implicate Myb in the control of cell division.
      Myb has been cloned and sequenced. It contains two regions of homology to vertebrate myb proteins. DNA-binding experiments show that the amino-terminal proximal region of homology functions as a DNA binding domain.
      Considered to be the Drosophila homologue of avian c-myb. Open reading frame identified to date encodes a polypeptide exhibiting 73% homology with chicken c-myb protein.
      Origin and Etymology
      Discoverer
      Etymology
      Identification
      External Crossreferences and Linkouts ( 49 )
      Sequence Crossreferences
      NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
      GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
      GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
      RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
      UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
      UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
      Other crossreferences
      BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
      Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
      Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
      Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
      Flygut - An atlas of the Drosophila adult midgut
      GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
      iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
      KEGG Genes - Molecular building blocks of life in the genomic space.
      modMine - A data warehouse for the modENCODE project
      SignaLink - A signaling pathway resource with multi-layered regulatory networks.
      Linkouts
      BioGRID - A database of protein and genetic interactions.
      DroID - A comprehensive database of gene and protein interactions.
      DRSC - Results frm RNAi screens
      FLIGHT - Cell culture data for RNAi and other high-throughput technologies
      FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
      FlyMine - An integrated database for Drosophila genomics
      Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
      InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
      MIST (genetic) - An integrated Molecular Interaction Database
      MIST (protein-protein) - An integrated Molecular Interaction Database
      Synonyms and Secondary IDs (21)
      Reported As
      Symbol Synonym
      l(1)XVI
      Name Synonyms
      Secondary FlyBase IDs
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        References (177)