FB2025_02 , released April 17, 2025
Gene: Dmel\Atpα
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General Information
Symbol
Dmel\Atpα
Species
D. melanogaster
Name
Na pump α subunit
Annotation Symbol
CG5670
Feature Type
FlyBase ID
FBgn0002921
Gene Model Status
Stock Availability
Enzyme Name (EC)
Na(+)/K(+)-exchanging ATPase (7.2.2.13)
P-type K(+) transporter (7.2.2.6)
Gene Summary
Na pump α subunit (Atpα) encodes an integral membrane cation antiporter protein that utilizes ATP to shuttle Na[+] and K[+] across the plasma membrane to maintain ion homeostasis. [Date last reviewed: 2019-03-07] (FlyBase Gene Snapshot)
Also Known As

Na,K-ATPase, Na pump alpha subunit, Na+K+ATPase, Na+/K+-ATPase, l(3)01164

Key Links
Genomic Location
Cytogenetic map
Sequence location
Recombination map
3-69
RefSeq locus
NT_033777 REGION:20948714..20976239
Sequence
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
Function
Gene Ontology (GO) Annotations (34 terms)
Molecular Function (5 terms)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
Terms Based on Predictions or Assertions (5 terms)
CV Term
Evidence
References
enables ATP binding
inferred from electronic annotation with InterPro:IPR001757, InterPro:IPR005775
inferred from electronic annotation with InterPro:IPR001757
inferred from electronic annotation with InterPro:IPR023299
inferred from sequence or structural similarity with RGD:2167
inferred from biological aspect of ancestor with PANTHER:PTN000643123
Biological Process (22 terms)
Terms Based on Experimental Evidence (16 terms)
CV Term
Evidence
References
inferred from mutant phenotype
inferred from direct assay
involved_in jump response
inferred from mutant phenotype
inferred from mutant phenotype
inferred from direct assay
inferred from mutant phenotype
inferred from mutant phenotype
inferred from mutant phenotype
inferred from mutant phenotype
involved_in tissue homeostasis
inferred from mutant phenotype
inferred from mutant phenotype
Terms Based on Predictions or Assertions (6 terms)
CV Term
Evidence
References
inferred from biological aspect of ancestor with PANTHER:PTN000643123
inferred from biological aspect of ancestor with PANTHER:PTN000643123
inferred from electronic annotation with InterPro:IPR005775
inferred from biological aspect of ancestor with PANTHER:PTN001944065
inferred from biological aspect of ancestor with PANTHER:PTN000643123
Cellular Component (7 terms)
Terms Based on Experimental Evidence (6 terms)
CV Term
Evidence
References
located_in cytoplasm
inferred from high throughput direct assay
located_in nucleus
inferred from direct assay
located_in plasma membrane
inferred from high throughput direct assay
located_in septate junction
inferred from direct assay
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
located_in membrane
inferred from electronic annotation with InterPro:IPR001757, InterPro:IPR005775
is_active_in plasma membrane
inferred from biological aspect of ancestor with PANTHER:PTN001944065
Protein Family (UniProt)
Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIC subfamily. (P13607)
Catalytic Activity (EC/Rhea)
P-type sodium:potassium-exchanging transporter activity
K(+)(out) + Na(+)(in) + ATP + H2O = K(+)(in) + Na(+)(out) + ADP + phosphate + H(+) (7.2.2.13)
RHEA 18353: P-type potassium transmembrane transporter activity
K(+)(out) + ATP + H2O = K(+)(in) + ADP + phosphate + H(+) (7.2.2.6)
RHEA 16777: ATP hydrolysis activity
RHEA 13065:
Summaries
Gene Snapshot
Na pump α subunit (Atpα) encodes an integral membrane cation antiporter protein that utilizes ATP to shuttle Na[+] and K[+] across the plasma membrane to maintain ion homeostasis. [Date last reviewed: 2019-03-07]
Gene Group (FlyBase)
NA+/K+ TRANSPORTING P-ATPASE - ALPHA SUBUNITS -
The Na+/K+ transporting P-ATPase α-subunit is the catalytic component of the sodium pump, which catalyzes hydrolysis of ATP coupled with the exchange of Na+ and K+ ions across the plasma membrane. (Adapted FBrf0155879.)
Protein Function (UniProtKB)
This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients.
(UniProt, P13607)
Phenotypic Description (Red Book; Lindsley and Zimm 1992)
Atpα: (Na+ + K+) ATPase α subunit
Structural gene for the α or catalytic subunit of Na+ K+ ATPase (ouabain sensitive). Immunofluorescence microscopy with a monoclonal antibody demonstrates high concentrations of (ATPase in adult muscle, nervous tissue, and Malpighian tubules; strong immunofluorescence observed in brain, optic lobes, photoreceptor cells of retina, and ventral thoracic neuromere. Flies heterozygous for Df(3R)r1-G6 which lacks Atpα, are sluggish and less tolerant of physical stress than normal.
Summary (Interactive Fly)

ion pump responsible for the cellular balance of sodium and potassium ions - regulation of neuronal excitability and auditory mechanosensation - epithelial junction function - tracheal tube-size control - septate junction function - neurodegeneration - muscles - malpighian tubules

Gene Model and Products
Number of Transcripts
11
Number of Unique Polypeptides
6

Please see the JBrowse view of Dmel\Atpα for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Structure
Protein 3D structure   (Predicted by AlphaFold)   (AlphaFold entry P13607)

If you don't see a structure in the viewer, refresh your browser.
Model Confidence:
  • Very high (pLDDT > 90)
  • Confident (90 > pLDDT > 70)
  • Low (70 > pLDDT > 50)
  • Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures
Crossreferences
Comments on Gene Model

Tissue-specific extension of 3' UTRs observed during later stages (FBrf0218523, FBrf0219848); all variants may not be annotated

Low-frequency RNA-Seq exon junction(s) not annotated.

Annotated transcripts do not represent all supported alternative splices within 5' UTR.

Annotated transcripts do not represent all possible combinations of alternative exons and/or alternative promoters.

Gene model reviewed during 5.46

Gene model reviewed during 5.55

Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
FBtr0089510
3558
1041
FBtr0089511
3861
1002
FBtr0089509
4524
1002
FBtr0089512
5099
839
FBtr0089513
5033
1002
FBtr0089514
4524
1002
FBtr0089515
4524
1002
FBtr0089516
4808
1002
FBtr0300191
4524
1002
FBtr0333324
5545
1002
FBtr0333325
3721
1002
Additional Transcript Data and Comments
Reported size (kB)

4.8, 3.8 (northern blot); 3.6 (unknown)

6.5, 4.5, 4.2 (northern blot)

Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
UniProt
RefSeq ID
GenBank
FBpp0088502
115.6
1041
5.40
FBpp0088503
111.1
1002
5.25
FBpp0088501
111.1
1002
5.25
FBpp0088504
92.0
839
5.33
FBpp0088984
111.1
1002
5.25
FBpp0088983
111.2
1002
5.20
FBpp0088982
111.3
1002
5.26
FBpp0088981
111.2
1002
5.20
FBpp0289428
111.2
1002
5.15
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

1002 aa isoforms: Atpα-PF, Atpα-PH
Additional Polypeptide Data and Comments
Reported size (kDa)

1038 (aa); 100 (kD observed)

Comments
External Data
Subunit Structure (UniProtKB)

The sodium/potassium-transporting ATPase is composed of a catalytic alpha subunit, an auxiliary non-catalytic beta subunit and an additional regulatory subunit.

(UniProt, P13607)
Linkouts
Sequences Consistent with the Gene Model
Nucleotide / Polypeptide Records
 
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Atpα using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-0.87

Transcript Expression
microinjection
Stage
Tissue/Position (including subcellular localization)
Reference
northern blot
Stage
Tissue/Position (including subcellular localization)
Reference
Additional Descriptive Data

RNA-seq data show that Atpα is expressed throughout the larval midgut but is enriched in the acidic region of the larval midgut. It is also expressed in the gastric caecum.

Atpα transcripts are found in all body parts and stages examined by northern blots. The smaller transcripts are found in greater abundance than the larger transcript in adult abdomens, embryos, larval salivary glands, and larval Malpighian tubules and the reverse is true in the adult head and larval brain. The three transcripts are found at roughly equal abundance in the adult thorax.

Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
immunolocalization
Stage
Tissue/Position (including subcellular localization)
Reference
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
Additional Descriptive Data

Atpα protein is expressed in the Johnston organ, with highest expression levels observed in the scolopale cells.

In retinula cells (photoreceptors) of ocelli, Atpα is restricted to membranes proximal to the rhabdomeres.

Atpα is prominent in all areas of the brain including the optic lobes and the retina.

Atpα protein is detected in the optic neuropil in both the lamina and the medulla and exhibits cirdacian cycling. Levels are highest at ZT13 and lowest at ZT16. The highest signal is in epithelial glial cells.

Atpα protein shows high expression in Malpighian tubules, muscles and the nervous system (as assayed in adult sections with an antibody to avian sodium pump alpha subunit).

Marker for
 
Subcellular Localization
CV Term
Evidence
References
located_in cytoplasm
inferred from high throughput direct assay
located_in nucleus
inferred from direct assay
located_in plasma membrane
inferred from high throughput direct assay
located_in septate junction
inferred from direct assay
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\Atpα in JBrowse
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 116 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 23 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of Atpα
Transgenic constructs containing regulatory region of Atpα
Aberrations (Deficiencies and Duplications) ( 8 )
Variants
Variant Molecular Consequences
Alleles Representing Disease-Implicated Variants
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
Sterility
Allele
Other Phenotypes
Allele
Phenotype manifest in
Allele
Orthologs
Human Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Alignment
Complementation?
Transgene?
Homo sapiens (Human) (23)
13 of 14
Yes
Yes
1  
12 of 14
No
Yes
12 of 14
No
Yes
10 of 14
No
Yes
7 of 14
No
Yes
7 of 14
No
Yes
2 of 14
No
No
2 of 14
No
No
2 of 14
No
No
2 of 14
No
No
2 of 14
No
No
2  
2 of 14
No
No
2 of 14
No
No
1  
2 of 14
No
No
2 of 14
No
No
1 of 14
No
No
2  
1 of 14
No
No
1 of 14
No
No
1  
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1  
1 of 14
No
No
1 of 14
No
No
Model Organism Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Alignment
Complementation?
Transgene?
Rattus norvegicus (Norway rat) (15)
13 of 14
Yes
Yes
12 of 14
No
Yes
 
1  
12 of 14
No
Yes
11 of 14
No
Yes
7 of 14
No
Yes
7 of 14
No
Yes
2 of 14
No
No
2 of 14
No
No
2 of 14
No
No
2 of 14
No
No
2 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
Mus musculus (laboratory mouse) (15)
13 of 14
Yes
Yes
12 of 14
No
Yes
12 of 14
No
Yes
10 of 14
No
Yes
7 of 14
No
Yes
7 of 14
No
Yes
2 of 14
No
No
2 of 14
No
No
2 of 14
No
No
2 of 14
No
No
2 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
Xenopus tropicalis (Western clawed frog) (16)
8 of 13
Yes
Yes
7 of 13
No
Yes
7 of 13
No
Yes
4 of 13
No
Yes
2 of 13
No
No
2 of 13
No
No
2 of 13
No
No
2 of 13
No
No
2 of 13
No
Yes
1 of 13
No
No
1 of 13
No
No
1 of 13
No
No
1 of 13
No
No
1 of 13
No
No
1 of 13
No
No
1 of 13
No
Yes
Danio rerio (Zebrafish) (22)
13 of 14
Yes
Yes
12 of 14
No
Yes
12 of 14
No
Yes
12 of 14
No
Yes
12 of 14
No
Yes
12 of 14
No
Yes
12 of 14
No
Yes
12 of 14
No
Yes
10 of 14
No
Yes
2 of 14
No
No
2 of 14
No
No
2 of 14
No
No
2 of 14
No
No
2 of 14
No
No
2 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
Caenorhabditis elegans (Nematode, roundworm) (15)
13 of 14
Yes
Yes
8 of 14
No
Yes
7 of 14
No
Yes
6 of 14
No
No
5 of 14
No
Yes
2 of 14
No
No
2 of 14
No
No
2 of 14
No
No
2 of 14
No
No
2 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
Anopheles gambiae (African malaria mosquito) (7)
11 of 12
Yes
Yes
2 of 12
No
No
Arabidopsis thaliana (thale-cress) (36)
3 of 13
Yes
No
3 of 13
Yes
No
3 of 13
Yes
No
2 of 13
No
No
2 of 13
No
No
2 of 13
No
No
2 of 13
No
No
2 of 13
No
No
2 of 13
No
No
2 of 13
No
No
2 of 13
No
No
2 of 13
No
No
2 of 13
No
No
2 of 13
No
No
2 of 13
No
No
1 of 13
No
Yes
1 of 13
No
Yes
1 of 13
No
Yes
1 of 13
No
Yes
1 of 13
No
Yes
1 of 13
No
Yes
1 of 13
No
Yes
1 of 13
No
Yes
1 of 13
No
Yes
1 of 13
No
Yes
1 of 13
No
Yes
1 of 13
No
Yes
1 of 13
No
No
1 of 13
No
No
1 of 13
No
No
1 of 13
No
No
1 of 13
No
No
1 of 13
No
No
1 of 13
No
No
1 of 13
No
No
1 of 13
No
No
Saccharomyces cerevisiae (Brewer's yeast) (11)
2 of 13
Yes
No
2 of 13
Yes
No
2 of 13
Yes
No
2 of 13
Yes
No
2 of 13
Yes
No
1 of 13
No
No
1 of 13
No
No
1 of 13
No
No
1 of 13
No
No
1 of 13
No
No
1 of 13
No
No
Schizosaccharomyces pombe (Fission yeast) (5)
3 of 12
Yes
No
2 of 12
No
No
1 of 12
No
Yes
1 of 12
No
Yes
1 of 12
No
No
Escherichia coli (enterobacterium) (1)
6 of 11
Yes
Yes
Other Organism Orthologs (via OrthoDB)
Data provided directly from OrthoDB:Atpα. Refer to their site for version information.
Paralogs
Paralogs (via DIOPT v9.1)
Drosophila melanogaster (Fruit fly) (10)
9 of 13
5 of 13
4 of 13
3 of 13
1 of 13
1 of 13
1 of 13
1 of 13
1 of 13
1 of 13
Human Disease Associations
FlyBase Human Disease Model Reports
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 16 )
Potential Models Based on Orthology ( 7 )
Modifiers Based on Experimental Evidence ( 3 )
Allele
Disease
Interaction
References
is ameliorated by Sec152
is ameliorated by slmb00295
is ameliorated by Dyrk21
is ameliorated by spz5e03444
is ameliorated by GαoMI00833
is ameliorated by Pur1
is ameliorated by cact7
is ameliorated by painEP2451
Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)
Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
Functional Complementation Data
Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
Dmel gene
Ortholog showing functional complementation
Supporting References
Interactions
Summary of Physical Interactions
Interaction Browsers

Please see the Physical Interaction reports below for full details
protein-protein
Physical Interaction
Assay
References
Summary of Genetic Interactions
Interaction Browsers

Please look at the allele data for full details of the genetic interactions
Starting gene(s)
Interaction type
Interacting gene(s)
Reference
Starting gene(s)
Interaction type
Interacting gene(s)
Reference
External Data
Subunit Structure (UniProtKB)
The sodium/potassium-transporting ATPase is composed of a catalytic alpha subunit, an auxiliary non-catalytic beta subunit and an additional regulatory subunit.
(UniProt, P13607 )
Linkouts
BioGRID - A database of protein and genetic interactions.
DroID - A comprehensive database of gene and protein interactions.
MIST (protein-protein) - An integrated Molecular Interaction Database
Pathways
Signaling Pathways (FlyBase)
Metabolic Pathways
FlyBase
External Links
External Data
Linkouts
Class of Gene
Genomic Location and Detailed Mapping Data
Chromosome (arm)
3R
Recombination map
3-69
Cytogenetic map
Sequence location
FlyBase Computed Cytological Location
Cytogenetic map
Evidence for location
93A4-93A4
Limits computationally determined from genome sequence between P{EP}SyndEP409 and P{lacW}l(3)j5C7j5C7
Experimentally Determined Cytological Location
Cytogenetic map
Notes
References
93A7-93B1
(determined by in situ hybridisation)
93B2-93B2
93B-93B
(determined by in situ hybridisation)
93B1-93B2
93B1--3 93B2--3
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Stocks and Reagents
Stocks (48)
Genomic Clones (31)
cDNA Clones (154)
 

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced
BDGP DGC clones
Other clones
Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

cDNA Clones, End Sequenced (ESTs)
RNAi and Array Information
Linkouts
DRSC - Results frm RNAi screens
Antibody Information
Laboratory Generated Antibodies
 
Commercially Available Antibodies
 
Developmental Studies Hybridoma Bank - Monoclonal antibodies for use in research
Cell Line Information
Publicly Available Cell Lines
 
    Other Stable Cell Lines
     
      Other Comments

      Mutant embryos have lengthened primary tracheal tubes with expanded diameters, and defective septate junctions.

      Analysis of the conserved core sequence in 159 P-type ATPases from the 3 domains of life (Archaea, Bacteria and Eukarya) establishes 5 major groups of P-type ATPases.

      The genomic organisation of the Atpα locus has been characterised.

      The autosomal "FLP-DFS" technique (using the P{ovoD1-18} P{FRT(whs)} P{hsFLP} chromosomes) has been used to identify the specific maternal effect phenotype for the zygotic lethal mutation.

      Atpα and l(3)01453 are likely to be the same gene but it is not yet proven.

      Structural gene for the α or catalytic subunit of Na+ K+ ATPase (ouabain sensitive). Immunofluorescence microscopy with a monoclonal antibody demonstrates high concentrations of αATPase in adult muscle, nervous tissue and Malpighian tubules; strong immunofluorescence observed in brain, optic lobes, photoreceptor cells of retina and ventral thoracic neuromere.

      Flies heterozygous for Hypomorphic mutant alleles show a bang-sensitive phenotype and are lethargic. Haplo-insufficient - flies heterozygous for a complete deletion are sluggish and less tolerant of physical stress than normal.

      Relationship to Other Genes
      Source for database merge of

      Source for merge of: Atpα l(3)04492

      Source for merge of: Atpα CG5670

      Additional comments
      Nomenclature History
      Source for database identify of
      Nomenclature comments
      Etymology
      Synonyms and Secondary IDs (80)
      Reported As
      Symbol Synonym
      (Na+/k+)-ATPase
      JY
      Na+-K+-ATPase
      Na+/K+ ATPase alpha subunit
      Na-p
      Na/K-ATPase
      Na/K-ATPase alpha-subunit
      Na/K-ATPase α-subunit
      Na+, K+ -ATPase
      Na+,K+-ATPase
      Na+,K+-ATPase α subunit
      Na+-K+-ATPase α5-subunit
      Na+/K+ ATPase
      Na+/K+ATPase
      Na+K+-ATPase
      NaK-ATPase
      l(3)01453
      l(3)04492
      l(3)j3B2
      l(3)j3B7
      l(3)j6A4
      l(3)rM454
      l(3)ry136
      sodium/potassium transporting ATPase alpha
      Name Synonyms
      (Na+ + K+)-ATPase α-subunit
      (Na+,K+)ATPase α subunit
      ATPase α subunit
      Na+,K+ ATPase alpha-subunit
      Na+K+ ATPase α subunit
      Na, K ATPase a subunit
      Na,K ATPase α subunit
      Na,K-ATPase alpha
      Na,K-ATPase α subunit
      Na,K-ATPase α-subunit
      Na<up> +</up> , K<up> +</up> -ATPase
      Na+ pump α subunit
      Na+, K+ ATPase alpha
      Na+,K+ ATPase α subunit
      Na+,K+-ATPase α subunit
      Na+-K+ ATPase
      Na+/K+ ATPase (α subunit)
      Na+/K+ ATPase alpha subunit
      Na+/K+-ATPase
      Na+K+ ATPase alpha subunit
      Na+K+ATPase
      Sodium pump alpha subunit
      sodium pump α-subunit
      α-subunit of ATPase
      Secondary FlyBase IDs
      • FBgn0004667
      • FBgn0010739
      • FBgn0010749
      • FBgn0011344
      • FBgn0011348
      • FBgn0011389
      • FBgn0011518
      • FBgn0014319
      • FBgn0024511
      • FBgn0038844
      Datasets (0)
      Study focus (0)
      Experimental Role
      Project
      Project Type
      Title
      Study result (0)
      Result
      Result Type
      Title
      External Crossreferences and Linkouts ( 107 )
      Sequence Crossreferences
      NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
      GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
      RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
      UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.
      UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
      UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
      Other crossreferences
      AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.
      DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
      EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
      FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
      FlyMine - An integrated database for Drosophila genomics
      KEGG Genes - Molecular building blocks of life in the genomic space.
      MARRVEL_MODEL - MARRVEL (model organism gene)
      Linkouts
      BioGRID - A database of protein and genetic interactions.
      Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
      DroID - A comprehensive database of gene and protein interactions.
      DRSC - Results frm RNAi screens
      Developmental Studies Hybridoma Bank - Monoclonal antibodies for use in research
      Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
      FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
      FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
      Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
      Flygut - An atlas of the Drosophila adult midgut
      FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.
      iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
      Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
      MIST (protein-protein) - An integrated Molecular Interaction Database
      References (321)