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Gene: Dmel\Atpα

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General Information
Symbol
Dmel\Atpα
Species
D. melanogaster
Name
Na pump α subunit
Annotation Symbol
CG5670
Feature Type
protein_coding_gene
FlyBase ID
FBgn0002921
Gene Model Status
Current
Stock Availability
29 publicly available
Enzyme Name (EC)
Sodium/potassium-exchanging ATPase (3.6.3.9)
Gene Snapshot
Na pump α subunit is an integral membrane cation antiporter protein that utilizes ATP to shuttle Na+ and K+ across the plasma membrane to maintain ion homeostasis. [Date last reviewed: 2016-09-15]
Other Summaries
Also Known As
ATPα, Na+,K+-ATPase α-subunit, l(3)01164, Na,K-ATPase, Na+/K+-ATPase
Key Links
Genomic Location
Cytogenetic map
93A4-93A4
Sequence location
3R:20,948,714..20,976,239 [+]
Recombination map
3-69
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI Genome Data Viewer
UCSC Genome Browser
Ensembl Genome Browser
PopFly Genome Browser
GO Summary Ribbons
Families, Domains and Molecular Function
Gene Group Membership (FlyBase)
Protein Family (UniProt, Sequence Similarities)
Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIC subfamily. (P13607)
Protein Domains/Motifs
InterPro
P-type ATPase; Cation-transporting P-type ATPase, N-terminal; P-type ATPase subfamily IIC, subunit alpha; Cation-transporting P-type ATPase, C-terminal; P-type ATPase, A domain superfamily; P-type ATPase, phosphorylation site; HAD superfamily; P-type ATPase, transmembrane domain superfamily; P-type ATPase, cytoplasmic domain N; HAD-like superfamily
Molecular Function (see GO section for details)
Experimental Evidence
contributes_to cation transmembrane transporter activity; contributes_to sodium:potassium-exchanging ATPase activity
Predictions / Assertions
ATP binding; sodium:potassium-exchanging ATPase activity
Catalytic Activity (EC)
Experimental Evidence
ATP + H(2)O + Na(+)(In) + K(+)(Out) = ADP + phosphate + Na(+)(Out) + K(+)(In) (3.6.3.9)
Predictions / Assertions
ATP + H(2)O + Na(+)(In) + K(+)(Out) = ADP + phosphate + Na(+)(Out) + K(+)(In) (3.6.3.9)
Summaries
Gene Group Membership
NA+/K+ TRANSPORTING P-ATPASE - ALPHA SUBUNITS -
The Na[+]/K[+] transporting P-ATPase α-subunit is the catalytic component of the sodium pump, which catalyzes hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. (Adapted FBrf0155879).
UniProt Contributed Function Data
This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients.
(UniProt, P13607)
Phenotypic Description from the Red Book (Lindsley and Zimm 1992)
Atpα: (Na+ + K+) ATPase α subunit
Structural gene for the α or catalytic subunit of Na+ K+ ATPase (ouabain sensitive). Immunofluorescence microscopy with a monoclonal antibody demonstrates high concentrations of (ATPase in adult muscle, nervous tissue, and Malpighian tubules; strong immunofluorescence observed in brain, optic lobes, photoreceptor cells of retina, and ventral thoracic neuromere. Flies heterozygous for Df(3R)r1-G6 which lacks Atpα, are sluggish and less tolerant of physical stress than normal.
Interactive Fly
ion pump responsible for the cellular balance of sodium and potassium ions - regulation of neuronal excitability and auditory mechanosensation - epithelial junction function - tracheal tube-size control - septate junction function - neurodegeneration - muscles - malpighian tubules
Gene Model and Products
Number of Transcripts
11
Number of Unique Polypeptides
6

Please see the GBrowse view of Dmel\Atpα or the JBrowse view of Dmel\Atpα for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model
Tissue-specific extension of 3' UTRs observed during later stages (FBrf0218523, FBrf0219848); all variants may not be annotated
Low-frequency RNA-Seq exon junction(s) not annotated.
Annotated transcripts do not represent all supported alternative splices within 5' UTR.
Annotated transcripts do not represent all possible combinations of alternative exons and/or alternative promoters.
Gene model reviewed during 5.46
Gene model reviewed during 5.55
Sequence Ontology: Class of Gene
gene_with_edited_transcript
(Rodriguez et al., 2012, Graveley et al., 2011, Stapleton et al., 2006)
nuclear_gene
protein_coding_gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
Atpα-RA
FBtr0089510
NM_169936
3558
1041
Atpα-RB
FBtr0089511
NM_169937
3861
1002
Atpα-RC
FBtr0089509
NM_169938
4524
1002
Atpα-RD
FBtr0089512
NM_169939
5099
839
Atpα-RE
FBtr0089513
NM_206528
5033
1002
Atpα-RF
FBtr0089514
NM_206527
4524
1002
Atpα-RG
FBtr0089515
NM_206526
4524
1002
Atpα-RH
FBtr0089516
NM_206525
4808
1002
Atpα-RI
FBtr0300191
NM_001170196
4524
1002
Atpα-RJ
FBtr0333324
NM_001275861
5545
1002
Atpα-RK
FBtr0333325
NM_001275862
3721
1002
Additional Transcript Data and Comments
Reported size (kB)
4.8, 3.8 (northern blot); 3.6 (unknown)
(Lebovitz et al., 1989)
6.5, 4.5, 4.2 (northern blot)
(Varadi et al., 1989)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
Atpα-PA
FBpp0088502
115.6
1041
5.40
NP_732572
AAF55825
Atpα-PB
FBpp0088503
111.1
1002
5.25
NP_732573
AAF55828
Atpα-PC
FBpp0088501
111.1
1002
5.25
NP_732574
AAF55827
Atpα-PD
FBpp0088504
92.0
839
5.33
NP_732575
AAF55826
Atpα-PE
FBpp0088984
111.1
1002
5.25
NP_996250
AAS65183
Atpα-PF
FBpp0088983
111.2
1002
5.20
NP_996249
AAS65184
Atpα-PG
FBpp0088982
111.3
1002
5.26
NP_996248
AAS65186
Atpα-PH
FBpp0088981
111.2
1002
5.20
NP_996247
AAS65185
Atpα-PI
FBpp0289428
111.2
1002
5.15
NP_001163667
ACZ94963
Atpα-PJ
FBpp0305516
111.1
1002
5.25
NP_001262790
AGB96170
Atpα-PK
FBpp0305517
111.1
1002
5.25
NP_001262791
AGB96171
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

1002 aa isoforms: Atpα-PB, Atpα-PC, Atpα-PE, Atpα-PJ, Atpα-PK
1002 aa isoforms: Atpα-PF, Atpα-PH
Additional Polypeptide Data and Comments
Reported size (kDa)
1038 (aa); 100 (kD observed)
(Lebovitz et al., 1989)
Comments
External Data
Subunit Structure (UniProtKB)
The sodium/potassium-transporting ATPase is composed of a catalytic alpha subunit, an auxiliary non-catalytic beta subunit and an additional regulatory subunit.
(UniProt, P13607)
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Nucleotide / Polypeptide Records
 
UniProt
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Atpα using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Gene Ontology (31 terms)
Molecular Function (3 terms)
Terms Based on Experimental Evidence (2 terms)
CV Term
Evidence
References
contributes_to cation transmembrane transporter activity
inferred from direct assay
(Sun et al., 1998)
sodium:potassium-exchanging ATPase activity
inferred from mutant phenotype
(Feng et al., 1997, Schubiger et al., 1994)
contributes_to sodium:potassium-exchanging ATPase activity
inferred from mutant phenotype
(Sun et al., 1998)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
ATP binding
inferred from electronic annotation with InterPro:IPR005775
(assigned by InterPro )
(FlyBase Curators et al., 2004-)
sodium:potassium-exchanging ATPase activity
inferred from biological aspect of ancestor with PANTHER:PTN000643123
(assigned by GO_Central )
(Gaudet et al., 2011)
inferred from sequence or structural similarity with RGD:2167
(Lebovitz et al., 1989)
Biological Process (21 terms)
Terms Based on Experimental Evidence (16 terms)
CV Term
Evidence
References
adult locomotory behavior
inferred from mutant phenotype
(Ashmore et al., 2009, Palladino et al., 2003)
cation transport
inferred from direct assay
(Sun et al., 1998, Feng et al., 1997)
chemical synaptic transmission
inferred from direct assay
(Trotta et al., 2004)
determination of adult lifespan
inferred from mutant phenotype
(Ashmore et al., 2009, Fergestad et al., 2006, Palladino et al., 2003)
jump response
inferred from mutant phenotype
(Ashmore et al., 2009)
locomotory behavior
inferred from mutant phenotype
(Sun et al., 2001)
neuromuscular process
inferred from mutant phenotype
(Palladino et al., 2003)
regulation of tube diameter, open tracheal system
inferred from mutant phenotype
(Hemphala et al., 2003, Paul et al., 2003)
regulation of tube length, open tracheal system
inferred from mutant phenotype
(Hemphala et al., 2003, Paul et al., 2003)
response to mechanical stimulus
inferred from mutant phenotype
(Palladino et al., 2003, Sun et al., 2001, Schubiger et al., 1994)
response to temperature stimulus
inferred from mutant phenotype
(Palladino et al., 2003, Feng et al., 1997)
sensory perception of sound
inferred from mutant phenotype
(Roy et al., 2013)
septate junction assembly
inferred from mutant phenotype
(Paul et al., 2003)
synaptic growth at neuromuscular junction
inferred from mutant phenotype
(Trotta et al., 2004)
tissue homeostasis
inferred from mutant phenotype
(Palladino et al., 2003)
trachea morphogenesis
inferred from mutant phenotype
(Ashmore et al., 2009)
Terms Based on Predictions or Assertions (5 terms)
CV Term
Evidence
References
ATP hydrolysis coupled proton transport
inferred from biological aspect of ancestor with PANTHER:PTN000643123
(assigned by GO_Central )
(Gaudet et al., 2011)
cellular potassium ion homeostasis
inferred from biological aspect of ancestor with PANTHER:PTN000643123
(assigned by GO_Central )
(Gaudet et al., 2011)
cellular sodium ion homeostasis
inferred from biological aspect of ancestor with PANTHER:PTN000643123
(assigned by GO_Central )
(Gaudet et al., 2011)
potassium ion import across plasma membrane
inferred from biological aspect of ancestor with PANTHER:PTN000643123
(assigned by GO_Central )
(Gaudet et al., 2011)
sodium ion export across plasma membrane
inferred from biological aspect of ancestor with PANTHER:PTN000643123
(assigned by GO_Central )
(Gaudet et al., 2011)
Cellular Component (7 terms)
Terms Based on Experimental Evidence (5 terms)
CV Term
Evidence
References
basolateral plasma membrane
inferred from direct assay
(Yano et al., 2012, Torrie et al., 2004)
cytoplasm
inferred from high throughput direct assay
(Lee et al., 2014)
nucleus
inferred from direct assay
(Schubiger et al., 1994)
plasma membrane
inferred from high throughput direct assay
(Tan et al., 2009)
inferred from direct assay
(Roy et al., 2013, Clyne et al., 2003, Schubiger et al., 1994)
septate junction
inferred from direct assay
(Genova and Fehon, 2003, Paul et al., 2003)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
integral component of membrane
inferred from electronic annotation with InterPro:IPR001757, InterPro:IPR005775
(assigned by InterPro )
(FlyBase Curators et al., 2004-)
sodium:potassium-exchanging ATPase complex
inferred by curator from GO:0005391
(Sun et al., 1998)
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
microinjection
Stage
Tissue/Position (including subcellular localization)
Reference
larval stage
embryonic/larval midgut

Comment: enriched in acidic region

(Overend et al., 2016)
gastric caecum
(Overend et al., 2016)
northern blot
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage -- adult stage
(Lebovitz et al., 1989)
larval stage
Malpighian tubule
(Lebovitz et al., 1989)
embryonic/larval brain
(Lebovitz et al., 1989)
embryonic/larval salivary gland
(Lebovitz et al., 1989)
adult stage
abdomen
(Lebovitz et al., 1989)
thorax
(Lebovitz et al., 1989)
adult head
(Lebovitz et al., 1989)
head
(Lebovitz et al., 1989)
adult thorax
(Lebovitz et al., 1989)
Additional Descriptive Data
RNA-seq data show that Atpα is expressed throughout the larval midgut but is enriched in the acidic region of the larval midgut. It is also expressed in the gastric caecum.
(Overend et al., 2016)
Atpα transcripts are found in all body parts and stages examined by northern blots. The smaller transcripts are found in greater abundance than the larger transcript in adult abdomens, embryos, larval salivary glands, and larval Malpighian tubules and the reverse is true in the adult head and larval brain. The three transcripts are found at roughly equal abundance in the adult thorax.
(Lebovitz et al., 1989)
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
immunolocalization
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 16
epithelial cell of embryonic/larval salivary gland
(Paul et al., 2003)
embryonic/larval tracheocyte
(Paul et al., 2003)
epidermal cell
(Paul et al., 2003)
adult stage
Malpighian tubule
(Lebovitz et al., 1989)
indirect flight muscle
(Lebovitz et al., 1989)
tubular muscle
(Lebovitz et al., 1989)
retina
(Lebovitz et al., 1989)
adult optic lobe

Comment: exhibits circadian cycling

(Górska-Andrzejak et al., 2009, Lebovitz et al., 1989)
thoracico-abdominal ganglion
(Lebovitz et al., 1989)
adult brain
(Lebovitz et al., 1989)
photoreceptor cell
(Lebovitz et al., 1989)
Johnston organ
(Roy et al., 2013)
Johnston organ neuron
(Roy et al., 2013)
lamina

Comment: exhibits circadian cycling

(Górska-Andrzejak et al., 2009)
medulla

Comment: exhibits circadian cycling

(Górska-Andrzejak et al., 2009)
glial cell | subset of lamina

Comment: exhibits circadian cycling

(Górska-Andrzejak et al., 2009)
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
adult head
(Aradska et al., 2015)
day 7 of adulthood -- day 49 of adulthood
adult heart
(Cammarato et al., 2011)
Additional Descriptive Data
Atpα protein is expressed in the Johnston organ, with highest expression levels observed in the scolopale cells.
(Roy et al., 2013)
Atpα protein is detected in the optic neuropil in both the lamina and the medulla and exhibits cirdacian cycling. Levels are highest at ZT13 and lowest at ZT16. The highest signal is in epithelial glial cells.
(Górska-Andrzejak et al., 2009)
Atpα protein shows high expression in Malpighian tubules, muscles and the nervous system (as assayed in adult sections with an antibody to avian sodium pump alpha subunit).
(Lebovitz et al., 1989)
Marker for
 
Subcellular Localization
CV Term
Evidence
References
basolateral plasma membrane
inferred from direct assay
(Yano et al., 2012, Torrie et al., 2004)
cytoplasm
inferred from high throughput direct assay
(Lee et al., 2014)
nucleus
inferred from direct assay
(Schubiger et al., 1994)
plasma membrane
inferred from high throughput direct assay
(Tan et al., 2009)
inferred from direct assay
(Roy et al., 2013, Clyne et al., 2003, Schubiger et al., 1994)
septate junction
inferred from direct assay
(Genova and Fehon, 2003, Paul et al., 2003)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\Atpα in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyBase Wiki
Image Based Resources
Alleles, Insertions, and Transgenic Constructs
Classical and Insertion Alleles ( 74 )
For All Classical and Insertion Alleles Show
 
Allele of Atpα
Class
Mutagen
Associated Insertion
Stocks
Known lesion
Atpα01453a
1
Yes
Atpα2206
hypomorphic allele - genetic evidence
0
Yes
Atpα01164
0
Yes
AtpαDTS1R1
loss of function allele, hypomorphic allele - molecular evidence
0
Yes
AtpαDTS1R2
loss of function allele, hypomorphic allele - molecular evidence
0
Yes
Atpα01278
0
Yes
Atpα07008
0
Yes
AtpαDTS1
heat sensitive gain of function allele
0
Yes
AtpαS067611
0
--
Atpαunspecified
    0
    --
    Atpα00462
    cold sensitive hypomorphic allele - molecular evidence
    0
    Yes
    Atpα04694
    0
    --
    AtpαDTS2
    heat sensitive gain of function allele
    0
    Yes
    Atpαj6A4
    0
    --
    AtpαG00109
    1
    Yes
    Atpα01856
    0
    --
    Atpα03803
    0
    --
    Atpα03924
    0
    --
    Atpα04270
    0
    --
    Atpα04492
    0
    Yes
    Atpα05810
    0
    --
    Atpα07097
    0
    --
    Atpα10407a
    0
    --
    AtpαA344.1M3
    0
    --
    AtpαCJ4
    0
    Yes
    AtpαCJ5
    0
    Yes
    AtpαCJ6
    hypomorphic allele - molecular evidence
    0
    Yes
    AtpαCJ10
    0
    Yes
    AtpαCJ12
    0
    Yes
    AtpαCJ13
    hypomorphic allele - molecular evidence
    0
    Yes
    AtpαDTS2R2
    hypomorphic allele - molecular evidence
    0
    Yes
    AtpαDTS2R3
    loss of function allele, hypomorphic allele - molecular evidence
    0
    Yes
    Atpαj3B2
    0
    --
    Atpαj3B7
    0
    --
    Atpαj5B13b
    0
    --
    Atpαj6B7
    0
    --
    AtpαrM454
    0
    --
    Atpαry136
    0
    --
    Atpα0359-G4
    1
    Yes
    Atpα0712-G4
    1
    Yes
    Atpαc02092
    1
    Yes
    Atpαc07032
    1
    Yes
    AtpαCPTI002761
    1
    Yes
    AtpαCPTI003614
    1
    Yes
    Atpαd04576
    1
    Yes
    Atpαd07240
    1
    Yes
    Atpαd08645
    1
    Yes
    Atpαe03730
    1
    Yes
    AtpαEY02875
    1
    Yes
    AtpαEY05545
      1
      Yes
      AtpαEY13069
      1
      Yes
      AtpαGSG3285-1
        1
        Yes
        AtpαMI05598
          1
          Yes
          AtpαMI05598-GFSTF.0
          1
          Yes
          AtpαNP1602
            1
            Yes
            AtpαNP5397
              1
              Yes
              AtpαUM-8229-3
                1
                Yes
                Atpα7a
                0
                Yes
                Atpα0359
                0
                Yes
                AtpαCC00319
                0
                Yes
                AtpαCJ7
                hypomorphic allele - molecular evidence
                0
                Yes
                Atpαd02881
                0
                Yes
                Atpαd04171
                0
                Yes
                Atpαd09162
                0
                Yes
                AtpαDTS2R1
                loss of function allele
                0
                Yes
                AtpαEP3537
                  0
                  Yes
                  AtpαEP3661
                    0
                    Yes
                    AtpαEP-MS2-131
                    0
                    Yes
                    AtpαGS3301
                      0
                      Yes
                      AtpαGX26268
                      0
                      --
                      AtpαH64
                      0
                      --
                      AtpαNP7509
                        0
                        Yes
                        AtpαS083508
                        0
                        Yes
                        AtpαWee-P283
                          0
                          Yes
                          Other relevant insertions
                          insertion of mobile activating element
                          Name
                          Expression Data
                          P{GSV1}C407C407
                          NA
                          miscellaneous insertions
                          Name
                          Expression Data
                          P{Ecol\lacO.256x.w}J3.2
                          NA
                          P{lacW}l(3)SH093SH093
                          NA
                          Transgenic Constructs ( 23 )
                          For All Alleles Carried on Transgenic Constructs Show
                          Transgenic constructs containing/affecting coding region of Atpα
                          Allele of Atpα
                          Mutagen
                          Associated Transgenic Construct
                          Stocks
                          AtpαGD3093
                          1
                          AtpαHMS00703
                          1
                          AtpαKK108782
                          1
                          AtpαHMS00047
                          1
                          AtpαUAS.ORF
                          1
                          AtpαD369N.UAS
                          0
                          AtpαGLC01778
                          1
                          AtpαJF02910
                          1
                          AtpαTKO.GS00991
                          1
                          AtpαD355N.ShortC.UAS
                          0
                          AtpαD369N.hs
                          0
                          AtpαD394N.LongB.UAS
                          0
                          AtpαD394N.LongC.UAS
                          0
                          Atpαhs.PS
                          0
                          AtpαLongA.UAS
                          0
                          AtpαLongB.UAS
                          0
                          AtpαLongC.UAS
                          0
                          AtpαNIG.5670R
                          0
                          AtpαShortA.UAS
                          0
                          AtpαShortB.UAS
                          0
                          AtpαShortC.UAS
                          0
                          AtpαShortD.UAS
                          0
                          AtpαUAS.cSa
                          0
                          Transgenic constructs containing regulatory region of Atpα
                          Deletions and Duplications ( 8 )
                          Phenotypes
                          For more details about a specific phenotype click on the relevant allele symbol.
                          Lethality
                          Allele
                          lethal
                          lethal, with Scer\GAL4btl.PS
                          lethal, with Scer\GAL4elav.PU
                          lethal, with Scer\GAL4nrv1.PS
                          lethal, with Scer\GAL4repo.PU
                          lethal (with AtpαCJ4)
                          lethal (with AtpαCJ5)
                          lethal (with AtpαCJ6)
                          lethal (with AtpαCJ10)
                          lethal (with AtpαCJ12)
                          lethal (with AtpαCJ13)
                          lethal (with AtpαDTS1R1)
                          lethal (with AtpαDTS2R3)
                          lethal | embryonic stage
                          lethal | embryonic stage | recessive
                          lethal | embryonic stage | rescuable maternal effect
                          lethal | heat sensitive (with AtpαCJ6)
                          lethal | heat sensitive (with AtpαCJ7)
                          lethal | heat sensitive (with AtpαCJ12)
                          lethal | heat sensitive (with AtpαCJ13)
                          lethal | recessive
                          lethal | recessive | cold sensitive
                          lethal - all die before end of embryonic stage
                          lethal - all die before end of embryonic stage (with Atpα01453a)
                          lethal - all die before end of embryonic stage (with Atpα2206)
                          lethal - all die before end of embryonic stage (with AtpαDTS1)
                          lethal - all die before end of embryonic stage (with AtpαDTS1R1)
                          lethal - all die before end of embryonic stage (with AtpαDTS1R2)
                          lethal - all die before end of embryonic stage (with AtpαDTS2)
                          lethal - all die before end of embryonic stage (with AtpαDTS2R1)
                          lethal - all die before end of embryonic stage (with AtpαDTS2R2)
                          lethal - all die before end of embryonic stage (with AtpαDTS2R3)
                          lethal - all die before end of embryonic stage (with AtpαH64)
                          lethal - all die before end of embryonic stage | recessive
                          lethal - all die before end of pupal stage, with Scer\GAL4pnr-MD237
                          lethal - all die before end of pupal stage (with Atpα2206)
                          lethal - all die before end of pupal stage (with AtpαDTS2)
                          lethal - all die during P-stage, with Scer\GAL4Mef2.PR
                          partially lethal, with Scer\GAL4nrv2.PS
                          partially lethal - majority die (with Atpα01453a)
                          partially lethal - majority die (with AtpαCJ4)
                          partially lethal - majority die (with AtpαCJ7)
                          partially lethal - majority die (with AtpαCJ12)
                          partially lethal - majority die (with AtpαDTS1)
                          partially lethal - majority die (with AtpαDTS2)
                          partially lethal - majority die | heat sensitive (with AtpαCJ5)
                          partially lethal - majority die | heat sensitive (with AtpαCJ7)
                          partially lethal - majority die | heat sensitive (with AtpαCJ10)
                          partially lethal - majority die | heat sensitive (with AtpαCJ12)
                          partially lethal - majority die | heat sensitive (with AtpαCJ13)
                          partially lethal - majority live (with Atpα01453a)
                          partially lethal - majority live (with Atpα2206)
                          viable
                          viable, with Dcr-2UAS.cDa, Scer\GAL4elav.PLu
                          viable, with Scer\GAL4tin.CΔ4
                          viable (with AtpαCJ5)
                          viable (with AtpαCJ6)
                          viable (with AtpαCJ7)
                          viable (with AtpαCJ10)
                          viable (with AtpαCJ12)
                          viable (with AtpαCJ13)
                          Sterility
                          Allele
                          fertile
                          Other Phenotypes
                          Allele
                          auditory perception defective, with Scer\GAL4ato.PU
                          auditory perception defective, with Scer\GAL4nompA.cK
                          bang sensitive
                          bang sensitive (with Atpα2206)
                          bang sensitive (with AtpαCJ4)
                          bang sensitive (with AtpαCJ6)
                          bang sensitive (with AtpαCJ7)
                          bang sensitive (with AtpαCJ12)
                          bang sensitive (with AtpαCJ13)
                          bang sensitive (with AtpαDTS1)
                          bang sensitive (with AtpαDTS1R1)
                          bang sensitive (with AtpαDTS2R3)
                          bang sensitive | adult stage | progressive, with Scer\GAL4repo
                          bang sensitive | dominant
                          bang sensitive | dominant | heat sensitive
                          bang sensitive | dominant | progressive
                          bang sensitive | dominant | progressive | heat sensitive
                          bang sensitive | heat sensitive
                          bang sensitive | heat sensitive, with Atpα2206
                          bang sensitive | heat sensitive, with AtpαD369N.hs
                          bang sensitive | heat sensitive (with AtpαCJ5)
                          bang sensitive | heat sensitive (with AtpαCJ7)
                          bang sensitive | heat sensitive (with AtpαCJ10)
                          bang sensitive | heat sensitive (with AtpαCJ12)
                          bang sensitive | recessive | cold sensitive
                          behavior defective, with Scer\GAL4nrv2.PS
                          chemical resistant, with Scer\GAL4nrv2.PS
                          chemical resistant | heat sensitive
                          chemical sensitive
                          chemical sensitive, with Scer\GAL4nrv2.PS
                          chemical sensitive | heat sensitive
                          chemical sensitive | heat sensitive, with Atpα2206
                          chemical sensitive | heat sensitive, with AtpαD369N.hs
                          circadian behavior defective | adult stage, with Scer\GAL4P2.4.Pdf
                          hypoactive
                          hypoactive | heat sensitive
                          hypoactive | heat sensitive, with Atpα2206
                          hypoactive | heat sensitive, with AtpαD369N.hs
                          increased cell death | adult stage | progressive, with Scer\GAL4GMR.long
                          locomotor behavior defective | adult stage
                          locomotor behavior defective | dominant
                          locomotor behavior defective | recessive
                          locomotor rhythm defective | dominant
                          long lived | dominant
                          neuroanatomy defective
                          neuroanatomy defective | adult stage | dominant
                          neuroanatomy defective | adult stage | recessive
                          neuroanatomy defective | dominant
                          neurophysiology defective
                          neurophysiology defective | adult stage, with Scer\GAL4GMR.long
                          neurophysiology defective | adult stage, with Scer\GAL4GMR.PF
                          neurophysiology defective | heat sensitive
                          neurophysiology defective | larval stage, with Scer\GAL4futsch-C380
                          optomotor response defective, with Scer\GAL4GMR.long
                          paralytic
                          paralytic | conditional
                          paralytic | dominant
                          paralytic | dominant | heat sensitive
                          paralytic | heat sensitive
                          paralytic | heat sensitive (with Atpα01453a)
                          paralytic | heat sensitive (with Atpα2206)
                          paralytic | heat sensitive (with AtpαDTS1)
                          paralytic | heat sensitive (with AtpαDTS2)
                          phototaxis defective | adult stage, with Scer\GAL4GMR.long
                          phototaxis defective | recessive
                          short lived
                          short lived | dominant
                          some die during embryonic stage
                          some die during embryonic stage (with Atpα01453a)
                          some die during embryonic stage (with Atpα2206)
                          some die during embryonic stage (with AtpαDTS1)
                          some die during embryonic stage (with AtpαDTS1R1)
                          some die during embryonic stage (with AtpαDTS1R2)
                          some die during embryonic stage (with AtpαDTS2)
                          some die during embryonic stage (with AtpαDTS2R1)
                          some die during embryonic stage (with AtpαDTS2R2)
                          some die during embryonic stage (with AtpαDTS2R3)
                          some die during embryonic stage (with AtpαH64)
                          some die during embryonic stage | recessive
                          some die during pupal stage, with Scer\GAL4pnr-MD237
                          some die during pupal stage (with Atpα2206)
                          some die during pupal stage (with AtpαDTS2)
                          Phenotype manifest in
                          Allele
                          adult brain
                          dorsal medial indirect flight muscle
                          dorsal trunk primordium
                          dorsal trunk primordium | embryonic stage 14
                          embryonic/first instar larval cuticle
                          embryonic/larval dorsal trunk
                          embryonic/larval ganglionic branch
                          embryonic segment
                          embryonic somatic muscle
                          eye, with Scer\GAL4GMR.long
                          eye, with Scer\GAL4GMR.PF
                          eye photoreceptor cell, with Scer\GAL4GMR.long
                          flight muscle
                          ganglionic branch primordium
                          giant fiber neuron, with Scer\GAL4GMR.long
                          Johnston organ, with Scer\GAL4nompA.cK
                          Malpighian tubule
                          neuromuscular junction
                          NMJ bouton | supernumerary
                          ommatidium, with Scer\GAL4GMR.long
                          presumptive embryonic/larval tracheal system
                          presumptive embryonic salivary gland
                          rhabdomere of eye photoreceptor cell | progressive, with Scer\GAL4GMR.long
                          segment
                          septate junction
                          thoracico-abdominal ganglion
                          tracheal branch primordium
                          Orthologs
                          Downloads
                          Download All DIOPT Orthologs
                          Download All OrthoDB Orthologs
                          Human Orthologs (via DIOPT v7.1)
                          Homo sapiens (Human) (6)
                          Species\Gene Symbol
                          Score
                          Best Score
                          Best Reverse Score
                          Source
                          Compara
                          eggNOG
                          Hieranoid
                          Homologene
                          Inparanoid
                          Isobase
                          OMA
                          OrthoDB
                          OrthoFinder
                          OrthoInspector
                          orthoMCL
                          Panther
                          Phylome
                          RoundUp
                          TreeFam
                          ZFIN
                          Alignment
                          Complementation?
                          Transgene?
                          Hsap\ATP1A1
                          13 of 15
                          Yes
                          Yes
                          Hsap\ATP1A3
                          13 of 15
                          Yes
                          Yes
                           
                          Hsap\ATP1A2
                          11 of 15
                          No
                          Yes
                          Hsap\ATP1A4
                          8 of 15
                          No
                          Yes
                          Hsap\ATP12A
                          7 of 15
                          No
                          Yes
                          Hsap\ATP4A
                          6 of 15
                          No
                          Yes
                          Model Organism Orthologs (via DIOPT v7.1)
                          Mus musculus (laboratory mouse) (6)
                          Species\Gene Symbol
                          Score
                          Best Score
                          Best Reverse Score
                          Source
                          Compara
                          eggNOG
                          Hieranoid
                          Homologene
                          Inparanoid
                          Isobase
                          OMA
                          OrthoDB
                          OrthoFinder
                          OrthoInspector
                          orthoMCL
                          Panther
                          Phylome
                          RoundUp
                          TreeFam
                          ZFIN
                          Alignment
                          Complementation?
                          Transgene?
                          Mmus\Atp1a3
                          14 of 15
                          Yes
                          Yes
                          Mmus\Atp1a1
                          13 of 15
                          No
                          Yes
                          Mmus\Atp1a2
                          11 of 15
                          No
                          Yes
                          Mmus\Atp1a4
                          9 of 15
                          No
                          Yes
                          Mmus\Atp12a
                          7 of 15
                          No
                          Yes
                          Mmus\Atp4a
                          5 of 15
                          No
                          Yes
                          Rattus norvegicus (Norway rat) (6)
                          Rnor\Atp1a1
                          11 of 13
                          Yes
                          Yes
                           
                           
                          Rnor\Atp1a2
                          9 of 13
                          No
                          Yes
                          Rnor\Atp1a3
                          9 of 13
                          No
                          Yes
                          Rnor\Atp12a
                          7 of 13
                          No
                          Yes
                          Rnor\Atp1a4
                          6 of 13
                          No
                          Yes
                          Rnor\Atp4a
                          5 of 13
                          No
                          Yes
                          Xenopus tropicalis (Western clawed frog) (5)
                          Xtro\atp1a3
                          8 of 12
                          Yes
                          Yes
                          Xtro\atp1a1
                          7 of 12
                          No
                          Yes
                          Xtro\atp1a2
                          7 of 12
                          No
                          Yes
                          Xtro\atp12a-like
                          4 of 12
                          No
                          Yes
                          Xtro\atp4a
                          3 of 12
                          No
                          Yes
                          Danio rerio (Zebrafish) (9)
                          Drer\atp1a3a
                          14 of 15
                          Yes
                          Yes
                          Drer\atp1a1a.1
                          12 of 15
                          No
                          Yes
                          Drer\atp1a1a.2
                          9 of 15
                          No
                          Yes
                          Drer\atp1a1a.4
                          8 of 15
                          No
                          Yes
                          Drer\atp1a1b
                          8 of 15
                          No
                          Yes
                          Drer\atp1a2a
                          8 of 15
                          No
                          Yes
                          Drer\atp1a1a.3
                          7 of 15
                          No
                          Yes
                          Drer\atp1a1a.5
                          7 of 15
                          No
                          Yes
                          Drer\atp1a3b
                          6 of 15
                          No
                          Yes
                          Caenorhabditis elegans (Nematode, roundworm) (5)
                          Cele\eat-6
                          13 of 15
                          Yes
                          Yes
                          Cele\catp-3
                          4 of 15
                          No
                          No
                          Cele\catp-2
                          3 of 15
                          No
                          No
                          Cele\catp-4
                          3 of 15
                          No
                          No
                          Cele\catp-1
                          2 of 15
                          No
                          No
                          Arabidopsis thaliana (thale-cress) (0)
                          No orthologs reported.
                          Saccharomyces cerevisiae (Brewer's yeast) (5)
                          Scer\ENA1
                          1 of 15
                          Yes
                          No
                          Scer\ENA2
                          1 of 15
                          Yes
                          No
                          Scer\ENA5
                          1 of 15
                          Yes
                          No
                          Scer\PMA1
                          1 of 15
                          Yes
                          Yes
                          Scer\PMR1
                          1 of 15
                          Yes
                          No
                          Schizosaccharomyces pombe (Fission yeast) (1)
                          Spom\cta3
                          1 of 12
                          Yes
                          No
                          Orthologs in Drosophila Species (via OrthoDB v9.1) ( EOG091901EL )
                          Organism
                          Common Name
                          Gene
                          AAA Syntenic Ortholog
                          Multiple Dmel Genes in this Orthologous Group
                          Drosophila melanogaster
                          fruit fly
                          Dmel\Atpα
                          Drosophila suzukii
                          Spotted wing Drosophila
                          Dsuz\DS10_00009030
                          Drosophila simulans
                          Dsim\GD19388
                          Drosophila sechellia
                          Dsec\GM15055
                          Drosophila erecta
                          Dere\GG24266
                          Drosophila yakuba
                          Dyak\GE25699
                          Drosophila ananassae
                          Dana\GF17998
                          Drosophila pseudoobscura pseudoobscura
                          Dpse\GA19046
                          Drosophila persimilis
                          Dper\GL24291
                          Drosophila willistoni
                          Dwil\GK11950
                          Drosophila virilis
                          Dvir\GJ10697
                          Drosophila mojavensis
                          Dmoj\GI10755
                          Drosophila grimshawi
                          Dgri\GH21713
                          Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG091500TG )
                          Organism
                          Common Name
                          Gene
                          Multiple Dmel Genes in this Orthologous Group
                          Musca domestica
                          House fly
                          Mdoa\17012568
                          Glossina morsitans
                          Tsetse fly
                          Gmor\GMOY003579
                          Lucilia cuprina
                          Australian sheep blowfly
                          Lcup\FF38_14114
                          Mayetiola destructor
                          Hessian fly
                          Mdes\Mdes001311
                          Aedes aegypti
                          Yellow fever mosquito
                          Aaeg\AAEL012062
                          Anopheles darlingi
                          American malaria mosquito
                          Adar\ADAC005766
                          Anopheles gambiae
                          Malaria mosquito
                          Agam\AGAP002858
                          Culex quinquefasciatus
                          Southern house mosquito
                          Cqui\CPIJ005966
                          Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W00OH )
                          Organism
                          Common Name
                          Gene
                          Multiple Dmel Genes in this Orthologous Group
                          Bombyx mori
                          Silkmoth
                          Bmor\BGIBMGA005058
                          Danaus plexippus
                          Monarch butterfly
                          Dple\DPOGS214640-PA
                          Heliconius melpomene
                          Postman butterfly
                          Hmel\HMEL005691
                          Apis florea
                          Little honeybee
                          Aflo\2157450900
                          Apis mellifera
                          Western honey bee
                          Amel\GB42054
                          Bombus impatiens
                          Common eastern bumble bee
                          Bimp\BIMP10181
                          Bombus terrestris
                          Buff-tailed bumblebee
                          Bter\15216345
                          Linepithema humile
                          Argentine ant
                          Lhum\LH21769
                          Megachile rotundata
                          Alfalfa leafcutting bee
                          Mrot\MROTU:001d88
                          Nasonia vitripennis
                          Parasitic wasp
                          Nvit\Nasvi2EG012301
                          Dendroctonus ponderosae
                          Mountain pine beetle
                          Dpod\YQE_11557
                          Tribolium castaneum
                          Red flour beetle
                          Tcas\TC033838
                          Pediculus humanus
                          Human body louse
                          Phum\PHUM336910
                          Pediculus humanus
                          Human body louse
                          Phum\PHUM361900
                          Rhodnius prolixus
                          Kissing bug
                          Rpro\RPRC000444
                          Cimex lectularius
                          Bed bug
                          Clec\CLEC006776
                          Acyrthosiphon pisum
                          Pea aphid
                          Apim\ACYPI008640
                          Zootermopsis nevadensis
                          Nevada dampwood termite
                          Znev\Znev_11385
                          Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X00OF )
                          Organism
                          Common Name
                          Gene
                          Multiple Dmel Genes in this Orthologous Group
                          Strigamia maritima
                          European centipede
                          Smar\SMAR009306
                          Strigamia maritima
                          European centipede
                          Smar\SMAR006718
                          Strigamia maritima
                          European centipede
                          Smar\SMAR006716
                          Ixodes scapularis
                          Black-legged tick
                          Isca\ISCW002538
                          Stegodyphus mimosarum
                          African social velvet spider
                          Smim\KFM73790.1
                          Stegodyphus mimosarum
                          African social velvet spider
                          Smim\KFM68400.1
                          Stegodyphus mimosarum
                          African social velvet spider
                          Smim\KFM80606.1
                          Tetranychus urticae
                          Two-spotted spider mite
                          Turt\tetur08g05620
                          Tetranychus urticae
                          Two-spotted spider mite
                          Turt\tetur27g01220
                          Tetranychus urticae
                          Two-spotted spider mite
                          Turt\tetur01g07010
                          Tetranychus urticae
                          Two-spotted spider mite
                          Turt\tetur08g05230
                          Daphnia pulex
                          Water flea
                          Dpux\DAPPUDRAFT_202800
                          Daphnia pulex
                          Water flea
                          Dpux\DAPPUDRAFT_305634
                          Daphnia pulex
                          Water flea
                          Dpux\DAPPUDRAFT_256165
                          Daphnia pulex
                          Water flea
                          Dpux\DAPPUDRAFT_305693
                          Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G01BB )
                          Organism
                          Common Name
                          Gene
                          Multiple Dmel Genes in this Orthologous Group
                          Strongylocentrotus purpuratus
                          Purple sea urchin
                          Spur\Sp-Atp1a3
                          Ciona intestinalis
                          Vase tunicate
                          Cint\LOC100175029
                          Gallus gallus
                          Domestic chicken
                          Ggal\ATP12A
                          Gallus gallus
                          Domestic chicken
                          Ggal\ATP1A1
                          Human Disease Model Data
                          FlyBase Human Disease Model Reports
                          Alleles Reported to Model Human Disease (Disease Ontology)
                          Download
                          Models ( 6 )
                          Allele
                          Disease
                          Evidence
                          References
                          AtpαDTS1R1
                          model of  familial hemiplegic migraine
                          inferred from mutant phenotype
                          (Ashmore et al., 2009)
                          AtpαCJ5
                          model of  familial hemiplegic migraine
                          inferred from mutant phenotype
                          (Ashmore et al., 2009)
                          AtpαCJ6
                          model of  familial hemiplegic migraine
                          inferred from mutant phenotype
                          (Ashmore et al., 2009)
                          AtpαCJ7
                          model of  familial hemiplegic migraine
                          inferred from mutant phenotype
                          (Ashmore et al., 2009)
                          AtpαCJ10
                          model of  familial hemiplegic migraine
                          inferred from mutant phenotype
                          (Ashmore et al., 2009)
                          AtpαCJ13
                          model of  familial hemiplegic migraine
                          inferred from mutant phenotype
                          (Ashmore et al., 2009)
                          Interactions ( 0 )
                          Allele
                          Disease
                          Interaction
                          References
                          Comments ( 0 )
                           
                          Human Orthologs (via DIOPT v7.1)
                          Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
                          Homo sapiens (Human)
                          Gene name
                          Score
                          OMIM
                          OMIM Phenotype
                          Complementation?
                          Transgene?
                          ATP1A1; ATPase Na+/K+ transporting subunit alpha 1
                          13 of 15
                          182310
                          ATP1A3; ATPase Na+/K+ transporting subunit alpha 3
                          13 of 15
                          182350
                           
                          ATP1A2; ATPase Na+/K+ transporting subunit alpha 2
                          11 of 15
                          182340
                          ATP1A4; ATPase Na+/K+ transporting subunit alpha 4
                          8 of 15
                          607321
                            ATP12A; ATPase H+/K+ transporting non-gastric alpha2 subunit
                            7 of 15
                            182360
                              ATP4A; ATPase H+/K+ transporting subunit alpha
                              6 of 15
                              137216
                                Functional Complementation Data
                                Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
                                Dmel gene
                                Ortholog showing functional complementation
                                Supporting References
                                Atpα
                                Rnor\Atp1a1
                                (Paul et al., 2007)
                                Interactions
                                Summary of Physical Interactions
                                esyN Network Diagram
                                Show neighbor-neighbor interactions:
                                Select Layout:
                                Legend:
                                Protein
                                RNA
                                Selected Interactor(s)
                                Interactions Browser
                                View in Interactions Browser
                                Please look at the Interaction Group reports for full details of the physical interactions
                                protein-protein
                                Interacting group
                                Assay
                                References
                                Atpα - Akt1
                                anti tag coimmunoprecipitation, Identification by mass spectrometry
                                (Vinayagam et al., 2016)
                                Atpα - CG33303
                                experimental knowledge based
                                (Guruharsha et al., 2011)
                                Atpα - Chc
                                experimental knowledge based
                                (Guruharsha et al., 2011)
                                Atpα - Hel25E
                                experimental knowledge based
                                (Guruharsha et al., 2011)
                                Atpα - Kap-α3
                                experimental knowledge based
                                (Guruharsha et al., 2011)
                                Atpα - Karyβ3
                                experimental knowledge based
                                (Guruharsha et al., 2011)
                                Atpα - MRP
                                experimental knowledge based
                                (Guruharsha et al., 2011)
                                Atpα - Mcad
                                experimental knowledge based
                                (Guruharsha et al., 2011)
                                Atpα - Mec2
                                experimental knowledge based
                                (Guruharsha et al., 2011)
                                Atpα - Ost48
                                experimental knowledge based
                                (Guruharsha et al., 2011)
                                Atpα - OstΔ
                                experimental knowledge based
                                (Guruharsha et al., 2011)
                                Atpα - Past1
                                experimental knowledge based
                                (Guruharsha et al., 2011)
                                Atpα - Rab1
                                experimental knowledge based
                                (Guruharsha et al., 2011)
                                Atpα - Ranbp9
                                experimental knowledge based
                                (Guruharsha et al., 2011)
                                Atpα - SERCA
                                experimental knowledge based
                                (Guruharsha et al., 2011)
                                Atpα - Sc2
                                experimental knowledge based
                                (Guruharsha et al., 2011)
                                Atpα - Scamp
                                experimental knowledge based
                                (Guruharsha et al., 2011)
                                Atpα - Sec61α
                                experimental knowledge based
                                (Guruharsha et al., 2011)
                                Atpα - UQCR-C2
                                experimental knowledge based
                                (Guruharsha et al., 2011)
                                Atpα - Ube3a
                                enzymatic study, western blot
                                (Jensen et al., 2013)
                                Atpα - Vha68-2
                                experimental knowledge based
                                (Guruharsha et al., 2011)
                                Atpα - ZnT63C
                                experimental knowledge based
                                (Guruharsha et al., 2011)
                                Atpα - gig
                                anti tag coimmunoprecipitation, Identification by mass spectrometry
                                (Vinayagam et al., 2016)
                                Atpα - mats
                                anti tag coimmunoprecipitation, peptide massfingerprinting
                                (Kwon et al., 2013)
                                Atpα - nrv2
                                experimental knowledge based
                                (Guruharsha et al., 2011)
                                Atpα - spidey
                                experimental knowledge based
                                (Guruharsha et al., 2011)
                                Atpα - wal
                                experimental knowledge based
                                (Guruharsha et al., 2011)
                                Atpα - yki
                                anti tag coimmunoprecipitation, peptide massfingerprinting
                                (Kwon et al., 2013)
                                Summary of Genetic Interactions
                                esyN Network Diagram
                                esyN Network Key:
                                Suppression
                                Enhancement
                                View in Interactions Browser
                                Please look at the allele data for full details of the genetic interactions
                                Starting gene(s)
                                Interaction type
                                Interacting gene(s)
                                Reference
                                Atpα
                                enhanceable
                                para
                                (Fergestad et al., 2006)
                                Atpα
                                suppressible
                                para
                                (Trotta et al., 2004)
                                Atpα
                                suppressible
                                sesB
                                (Trotta et al., 2004)
                                Starting gene(s)
                                Interaction type
                                Interacting gene(s)
                                Reference
                                para
                                enhanceable
                                Atpα
                                (Fergestad et al., 2006)
                                sesB
                                suppressible
                                Atpα
                                (Trotta et al., 2004)
                                Ube3a
                                suppressible
                                Atpα
                                (Hope et al., 2017)
                                External Data
                                Subunit Structure (UniProtKB)
                                The sodium/potassium-transporting ATPase is composed of a catalytic alpha subunit, an auxiliary non-catalytic beta subunit and an additional regulatory subunit.
                                (UniProt, P13607 )
                                Linkouts
                                BioGRID - A database of protein and genetic interactions.
                                DroID - A comprehensive database of gene and protein interactions.
                                InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
                                Pathways
                                Gene Group - Pathway Membership (FlyBase)
                                External Data
                                Linkouts
                                Genomic Location and Detailed Mapping Data
                                Chromosome (arm)
                                3R
                                Recombination map
                                3-69
                                Cytogenetic map
                                93A4-93A4
                                Sequence location
                                3R:20,948,714..20,976,239 [+]
                                FlyBase Computed Cytological Location
                                Cytogenetic map
                                Evidence for location
                                93A4-93A4
                                Limits computationally determined from genome sequence between P{EP}SyndEP409 and P{lacW}l(3)j5C7j5C7
                                Experimentally Determined Cytological Location
                                Cytogenetic map
                                Notes
                                References
                                93A7-93B1
                                (determined by in situ hybridisation)
                                (Ranz et al., 2001)
                                93B2-93B2
                                (Sun, 1998.1.25)
                                93B1-93B2
                                (determined by in situ hybridisation)
                                (Spradling et al., 1999, Perrimon et al., 1996, Schwarz, 1996, Schubiger et al., 1994, Berg and Spradling, 1991)
                                93B-93B
                                (determined by in situ hybridisation)
                                (Feng et al., 1997, Lebovitz et al., 1989)
                                93B1-93B2
                                93B1--3 93B2--3
                                (BDGP Project Members, 1994-1999)
                                Experimentally Determined Recombination Data
                                Location
                                3-69
                                (FlyBase, 2016)
                                3-73.4
                                (Comeron et al., 2012)
                                Left of (cM)
                                Right of (cM)
                                Notes
                                Stocks and Reagents
                                Stocks (29)
                                Genomic Clones (31)
                                cDNA Clones (194)
                                 

                                Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

                                cDNA clones, fully sequences
                                BDGP DGC clones
                                Other clones
                                Drosophila Genomics Resource Center cDNA clones

                                For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

                                cDNA Clones, End Sequenced (ESTs)
                                BDGP DGC clones
                                Other clones
                                RNAi and Array Information
                                Linkouts
                                DRSC - Results frm RNAi screens
                                GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
                                Antibody Information
                                Laboratory Generated Antibodies
                                 
                                Commercially Available Antibodies
                                 
                                Developmental Studies Hybridoma Bank - Monoclonal antibodies for use in research
                                Other Information
                                Relationship to Other Genes
                                Source for database identify of
                                Source for database merge of
                                Source for merge of: Atpα l(3)04492
                                (Beaton, 1999.12.12)
                                Source for merge of: Atpα CG5670
                                (Bayraktaroglu, 2000.4.13)
                                Additional comments
                                Other Comments
                                Mutant embryos have lengthened primary tracheal tubes with expanded diameters, and defective septate junctions.
                                (Paul et al., 2003)
                                Analysis of the conserved core sequence in 159 P-type ATPases from the 3 domains of life (Archaea, Bacteria and Eukarya) establishes 5 major groups of P-type ATPases.
                                (Axelsen and Palmgren, 1998)
                                The genomic organisation of the Atpα locus has been characterised.
                                (Feng et al., 1997)
                                The autosomal "FLP-DFS" technique (using the P{ovoD1-18} P{FRT(whs)} P{hsFLP} chromosomes) has been used to identify the specific maternal effect phenotype for the zygotic lethal mutation.
                                (Perrimon et al., 1996)
                                Atpα and l(3)01453 are likely to be the same gene but it is not yet proven.
                                (Schwarz, 1996)
                                Structural gene for the α or catalytic subunit of Na+ K+ ATPase (ouabain sensitive). Immunofluorescence microscopy with a monoclonal antibody demonstrates high concentrations of αATPase in adult muscle, nervous tissue and Malpighian tubules; strong immunofluorescence observed in brain, optic lobes, photoreceptor cells of retina and ventral thoracic neuromere.
                                Flies heterozygous for Hypomorphic mutant alleles show a bang-sensitive phenotype and are lethargic. Haplo-insufficient - flies heterozygous for a complete deletion are sluggish and less tolerant of physical stress than normal.
                                Origin and Etymology
                                Discoverer
                                Etymology
                                Identification
                                External Crossreferences and Linkouts ( 103 )
                                Sequence Crossreferences
                                NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
                                GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
                                GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
                                RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
                                UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
                                UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
                                Other crossreferences
                                InterPro - A database of protein families, domains and functional sites
                                Linkouts
                                ApoDroso - Functional genomic database for photoreceptor development, survival and function
                                BioGRID - A database of protein and genetic interactions.
                                Drosophila Genomics Resource Center - Drosophila Genomics Resource Center cDNA clones
                                DroID - A comprehensive database of gene and protein interactions.
                                DRSC - Results frm RNAi screens
                                Developmental Studies Hybridoma Bank - Monoclonal antibodies for use in research
                                Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
                                FLIGHT - Cell culture data for RNAi and other high-throughput technologies
                                FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
                                FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
                                Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
                                Flygut - An atlas of the Drosophila adult midgut
                                FlyMine - An integrated database for Drosophila genomics
                                GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
                                iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
                                Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
                                InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
                                KEGG Genes - Molecular building blocks of life in the genomic space.
                                MIST (protein-protein) - An integrated Molecular Interaction Database
                                modMine - A data warehouse for the modENCODE project
                                Synonyms and Secondary IDs (76)
                                Reported As
                                Symbol Synonym
                                (Na+/k+)-ATPase
                                (Verma and Tapadia, 2014)
                                ATP-alpha
                                (Zhang et al., 2013)
                                ATP-α
                                (Lee et al., 2014)
                                ATPBagr
                                (Nakahara and Carthew, 2004)
                                ATPa
                                (Paul et al., 2003)
                                ATPalpha
                                (Aw et al., 2017, Talsma et al., 2014, Caldwell et al., 2013, Liu et al., 2012, Ashmore et al., 2009, Palladino and Miller, 2007, Paul et al., 2005, Wu and Beitel, 2004, Anholt et al., 2003, Clyne et al., 2003, Palladino and Johnston, 2003, Palladino et al., 2003, Palladino et al., 2003)
                                ATPα
                                (Dalla et al., 2017, Hope et al., 2017, Matsushima et al., 2017, Overend et al., 2016, de Madrid et al., 2015, Gautam et al., 2015, Jensen et al., 2013, Roy et al., 2013, Gistelinck et al., 2012, Franco et al., 2011, Jayanandanan et al., 2011, Nilton et al., 2010, Tiklová et al., 2010, Górska-Andrzejak et al., 2009, Fergestad et al., 2008, Nicholson et al., 2008, Blard et al., 2007, Wu et al., 2004, Ghabrial et al., 2003, Paul et al., 2003)
                                Atp
                                (Neuert et al., 2017)
                                Atp a
                                (Trotta et al., 2003)
                                Atpa
                                (Yang et al., 2004)
                                Atpalpha
                                (Wang et al., 2018, Kline et al., 2017, Transgenic RNAi Project members, 2017-, Clandinin and Owens, 2016-, Lee et al., 2016, Aradska et al., 2015, Chen et al., 2015, Gene Disruption Project members, 2015-, Ramirez et al., 2015, Van Bortle et al., 2015, Ashwal-Fluss et al., 2014, Kwon et al., 2013, Kwon et al., 2013, Schertel et al., 2013, Japanese National Institute of Genetics, 2012.5.21, Rodriguez et al., 2012, Friedman et al., 2011, Seong et al., 2011, Christensen et al., 2009.6.15, Tan et al., 2009, Buszczak et al., 2007, Quinones-Coello, 2007, Molnar et al., 2006, Laviolette et al., 2005, Wang et al., 2004, Watson et al., 2001)
                                Atpα
                                (Sakakibara et al., 2018, Aigouy and Le Bivic, 2016, DeSalvo et al., 2014, Luan et al., 2014, Van Vranken et al., 2014, Chen and Zhang, 2013, Jaiswal et al., 2012, Paik et al., 2012, Baumann et al., 2010, Nelson et al., 2010, Nilton et al., 2010, Chew et al., 2009, Laprise et al., 2009, Loevenich et al., 2009, Jayaram et al., 2008, Kapelnikov et al., 2008, Paul et al., 2007, Stapleton et al., 2006, Wang et al., 2006, Tonning et al., 2005, Trotta et al., 2004)
                                CG5670
                                (Kolkhof et al., 2017, Neuert et al., 2017, Çiçek et al., 2016, Aradska et al., 2015, Hosono et al., 2015, Jensen et al., 2013, Schertel et al., 2013, Christis and Munro, 2012, Jaspers et al., 2012, Yano et al., 2012, Cammarato et al., 2011, Khanna et al., 2010, Ni et al., 2010.12.1, Keleman et al., 2009.8.5, Loevenich et al., 2009, Perkins et al., 2009, Quinones-Coello, 2007, Molnar et al., 2006, Laviolette et al., 2005, Brody et al., 2002, Labourier et al., 2002)
                                Da-47
                                (Lebovitz, 1995.3.21)
                                JY
                                NKA
                                (D'Silva et al., 2017)
                                Na+-K+-ATPase
                                (Satoh et al., 2002)
                                Na+/K+ ATPase alpha subunit
                                (Sun, 1998.1.25)
                                Na+/K+-ATPase
                                (Choubey and Roy, 2017, D'Silva et al., 2017)
                                Na,K ATPase
                                (Dubreuil et al., 1999)
                                Na,K-ATPase
                                (Okamura et al., 2001, Baumann et al., 1999, Bohrmann and Braun, 1999)
                                Na-p
                                Na/K ATPase
                                (Peterson and Krasnow, 2015)
                                Na/K-ATPase
                                (Muller, 2000)
                                Na/K-ATPase alpha-subunit
                                (Feng, 1996.4.18)
                                Na/K-ATPase α-subunit
                                (Yasuhara et al., 2000)
                                Na+, K+ -ATPase
                                (Cereijido et al., 2003)
                                Na+,K+-ATPase
                                (Tepass et al., 2001)
                                Na+,K+-ATPase α subunit
                                (Sun et al., 2001)
                                Na+,K+-ATPase α-subunit
                                (Baumann, 2001, Sun et al., 1998, Sun and Salvaterra, 1995)
                                Na+-K+-ATPase α5-subunit
                                (Sciortino et al., 2001)
                                Na+/K+ ATPase
                                (Chen and Haddad, 2004)
                                Na+/K+-ATPase
                                (Linton and O'Donnell, 1999)
                                Na+/K+ATPase
                                (Chen et al., 2002)
                                Na+K+ ATPase
                                (Moyer and Jacobs, 2008)
                                Na+K+-ATPase
                                (Satoh et al., 2013)
                                Na+K+ATPase
                                (Iwanami et al., 2016, Müller and Bossinger, 2003)
                                NaK
                                (Satoh et al., 2013, Li et al., 2007)
                                NaK ATPase
                                (Wu and Beitel, 2003)
                                NaK-ATPase
                                (Tepass, 2012)
                                atpalpha
                                (Chintapalli et al., 2013)
                                atpα
                                (Chen et al., 2012)
                                dnATPase
                                (Parisky et al., 2008)
                                l(3)01164
                                (Russell et al., 1998, Perrimon et al., 1996)
                                l(3)01453
                                l(3)04492
                                (Lee et al., 1993)
                                l(3)j3B2
                                l(3)j3B7
                                l(3)j6A4
                                l(3)rM454
                                l(3)ry136
                                sodium/potassium transporting ATPase alpha
                                (Varadi, 1995.2.23)
                                α-ATPase
                                (Wang et al., 2018)
                                Name Synonyms
                                (Na+ + K+)-ATPase α-subunit
                                (Lebovitz et al., 1989)
                                (Na+,K+)ATPase α subunit
                                (Schubiger et al., 1994)
                                ATPalpha
                                (Gohl et al., 2014)
                                ATPase α
                                (Schulte et al., 2006)
                                ATPase α subunit
                                (Schubiger et al., 1994)
                                Atpalpha
                                (Giot et al., 2003, Spradling et al., 1999)
                                Na pump alpha subunit
                                (Jaspers et al., 2012, Cammarato et al., 2011, Tan et al., 2009)
                                Na pump α subunit
                                (Chen and Zhang, 2013, Yano et al., 2012)
                                Na+,K+ ATPase alpha-subunit
                                (Lebovitz, 1995.3.21)
                                Na, K ATPase a subunit
                                (Robinson et al., 2010)
                                Na,K ATPase
                                (Baumann et al., 2010)
                                Na,K ATPase α subunit
                                (Dubreuil et al., 2000)
                                Na,K-ATPase
                                (Laprise et al., 2008)
                                Na,K-ATPase alpha
                                (Dalla et al., 2013)
                                Na,K-ATPase α subunit
                                (Dubreuil et al., 1997, Feng et al., 1997)
                                Na,K-ATPase α-subunit
                                (Dobler et al., 2012, Feng et al., 1997)
                                Na<up> +</up> , K<up> +</up> -ATPase
                                (Yano et al., 2012)
                                Na+ pump α subunit
                                (Kapelnikov et al., 2008)
                                Na+, K+ ATPase alpha
                                (Ashmore et al., 2009)
                                Na+,K+ ATPase α subunit
                                (Torrie et al., 2004)
                                Na+,K+-ATPase α subunit
                                (Sun et al., 1998)
                                Na+-K+ ATPase
                                (Li et al., 2007)
                                Na+/K+ ATPase (α subunit)
                                (Khanna et al., 2010)
                                Na+/K+ ATPase alpha subunit
                                (Pulver and Griffith, 2010)
                                Na+K+ ATPase alpha subunit
                                (Wightman et al., 2012)
                                Na+K+ATPase
                                (Satoh et al., 2015)
                                NaK-ATPase
                                (Laprise and Tepass, 2011)
                                Sodium pump alpha subunit
                                (Khanna et al., 2010)
                                sodium pump α-subunit
                                (Górska-Andrzejak et al., 2009)
                                α-subunit of ATPase
                                (Lee et al., 1993)
                                Secondary FlyBase IDs
                                • FBgn0004667
                                • FBgn0010739
                                • FBgn0010749
                                • FBgn0011344
                                • FBgn0011348
                                • FBgn0011389
                                • FBgn0011518
                                • FBgn0014319
                                • FBgn0024511
                                • FBgn0038844
                                Datasets (0)
                                Study focus (0)
                                Experimental Role
                                Project
                                Project Type
                                Title
                                References (256)