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FB2025_02
,
released April 17, 2025
Na,K-ATPase, Na pump alpha subunit, Na+K+ATPase, Na+/K+-ATPase, l(3)01164
ion pump responsible for the cellular balance of sodium and potassium ions - regulation of neuronal excitability and auditory mechanosensation - epithelial junction function - tracheal tube-size control - septate junction function - neurodegeneration - muscles - malpighian tubules
Please see the JBrowse view of Dmel\Atpα for information on other features
To submit a correction to a gene model please use the Contact FlyBase form
AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.
Tissue-specific extension of 3' UTRs observed during later stages (FBrf0218523, FBrf0219848); all variants may not be annotated
Low-frequency RNA-Seq exon junction(s) not annotated.
Annotated transcripts do not represent all supported alternative splices within 5' UTR.
Annotated transcripts do not represent all possible combinations of alternative exons and/or alternative promoters.
Gene model reviewed during 5.46
Gene model reviewed during 5.55
4.8, 3.8 (northern blot); 3.6 (unknown)
6.5, 4.5, 4.2 (northern blot)
1038 (aa); 100 (kD observed)
The sodium/potassium-transporting ATPase is composed of a catalytic alpha subunit, an auxiliary non-catalytic beta subunit and an additional regulatory subunit.
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Atpα using the Feature Mapper tool.
The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).
Comment: enriched in acidic region
RNA-seq data show that Atpα is expressed throughout the larval midgut but is enriched in the acidic region of the larval midgut. It is also expressed in the gastric caecum.
Atpα transcripts are found in all body parts and stages examined by northern blots. The smaller transcripts are found in greater abundance than the larger transcript in adult abdomens, embryos, larval salivary glands, and larval Malpighian tubules and the reverse is true in the adult head and larval brain. The three transcripts are found at roughly equal abundance in the adult thorax.
Comment: exhibits circadian cycling
Comment: exhibits circadian cycling
Comment: exhibits circadian cycling
Atpα protein is expressed in the Johnston organ, with highest expression levels observed in the scolopale cells.
In retinula cells (photoreceptors) of ocelli, Atpα is restricted to membranes proximal to the rhabdomeres.
Atpα is prominent in all areas of the brain including the optic lobes and the retina.
Atpα protein is detected in the optic neuropil in both the lamina and the medulla and exhibits cirdacian cycling. Levels are highest at ZT13 and lowest at ZT16. The highest signal is in epithelial glial cells.
Atpα protein shows high expression in Malpighian tubules, muscles and the nervous system (as assayed in adult sections with an antibody to avian sodium pump alpha subunit).
JBrowse - Visual display of RNA-Seq signals
View Dmel\Atpα in JBrowse
3-69
3-73.4
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Mutant embryos have lengthened primary tracheal tubes with expanded diameters, and defective septate junctions.
Analysis of the conserved core sequence in 159 P-type ATPases from the 3 domains of life (Archaea, Bacteria and Eukarya) establishes 5 major groups of P-type ATPases.
The genomic organisation of the Atpα locus has been characterised.
The autosomal "FLP-DFS" technique (using the P{ovoD1-18} P{FRT(whs)} P{hsFLP} chromosomes) has been used to identify the specific maternal effect phenotype for the zygotic lethal mutation.
Atpα and l(3)01453 are likely to be the same gene but it is not yet proven.
Structural gene for the α or catalytic subunit of Na+ K+ ATPase (ouabain sensitive). Immunofluorescence microscopy with a monoclonal antibody demonstrates high concentrations of αATPase in adult muscle, nervous tissue and Malpighian tubules; strong immunofluorescence observed in brain, optic lobes, photoreceptor cells of retina and ventral thoracic neuromere.
Flies heterozygous for Hypomorphic mutant alleles show a bang-sensitive phenotype and are lethargic. Haplo-insufficient - flies heterozygous for a complete deletion are sluggish and less tolerant of physical stress than normal.
Source for merge of: Atpα l(3)04492
Source for merge of: Atpα CG5670
