FB2019_05, released Oct 15, 2019

Gene: Dmel\Atpα

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General Information
Symbol
Dmel\Atpα
Species
D. melanogaster
Name
Na pump α subunit
Annotation Symbol
CG5670
Feature Type
protein_coding_gene
FlyBase ID
FBgn0002921
Gene Model Status
Current
Stock Availability
29 publicly available
Gene Snapshot
Na pump α subunit (Atpα) encodes an integral membrane cation antiporter protein that utilizes ATP to shuttle Na[+] and K[+] across the plasma membrane to maintain ion homeostasis. [Date last reviewed: 2019-03-07]
Other Summaries
Also Known As
Na,K-ATPase, Na+K+ATPase, Na pump alpha subunit, Na+,K+-ATPase α-subunit, l(3)01164
Key Links
Genomic Location
Cytogenetic map
93A4-93A4
Sequence location
3R:20,948,714..20,976,239 [+]
Recombination map
3-69
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
GO Summary Ribbons
Gene Group (FlyBase)
Protein Family (UniProt)
Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIC subfamily. (P13607)
Protein Signatures (InterPro)
Molecular Function (GO)
[Detailed GO annotations]
Experimental Evidence
contributes_to cation transmembrane transporter activity; contributes_to sodium:potassium-exchanging ATPase activity
Predictions / Assertions
ATP binding; sodium:potassium-exchanging ATPase activity
Summaries
Gene Group (FlyBase)
NA+/K+ TRANSPORTING P-ATPASE - ALPHA SUBUNITS -
The Na[+]/K[+] transporting P-ATPase α-subunit is the catalytic component of the sodium pump, which catalyzes hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. (Adapted FBrf0155879).
Protein Function (UniProtKB)
This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients.
(UniProt, P13607)
Phenotypic Description (Red Book; Lindsley and Zimm 1992)
Atpα: (Na+ + K+) ATPase α subunit
Structural gene for the α or catalytic subunit of Na+ K+ ATPase (ouabain sensitive). Immunofluorescence microscopy with a monoclonal antibody demonstrates high concentrations of (ATPase in adult muscle, nervous tissue, and Malpighian tubules; strong immunofluorescence observed in brain, optic lobes, photoreceptor cells of retina, and ventral thoracic neuromere. Flies heterozygous for Df(3R)r1-G6 which lacks Atpα, are sluggish and less tolerant of physical stress than normal.
Summary (Interactive Fly)
ion pump responsible for the cellular balance of sodium and potassium ions - regulation of neuronal excitability and auditory mechanosensation - epithelial junction function - tracheal tube-size control - septate junction function - neurodegeneration - muscles - malpighian tubules
Gene Model and Products
Number of Transcripts
11
Number of Unique Polypeptides
6

Please see the GBrowse view of Dmel\Atpα or the JBrowse view of Dmel\Atpα for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model
Tissue-specific extension of 3' UTRs observed during later stages (FBrf0218523, FBrf0219848); all variants may not be annotated
Low-frequency RNA-Seq exon junction(s) not annotated.
Annotated transcripts do not represent all supported alternative splices within 5' UTR.
Annotated transcripts do not represent all possible combinations of alternative exons and/or alternative promoters.
Gene model reviewed during 5.46
Gene model reviewed during 5.55
Sequence Ontology: Class of Gene
gene_with_edited_transcript
(Rodriguez et al., 2012, Graveley et al., 2011, Stapleton et al., 2006)
nuclear_gene
protein_coding_gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
Atpα-RA
FBtr0089510
NM_169936
3558
1041
Atpα-RB
FBtr0089511
NM_169937
3861
1002
Atpα-RC
FBtr0089509
NM_169938
4524
1002
Atpα-RD
FBtr0089512
NM_169939
5099
839
Atpα-RE
FBtr0089513
NM_206528
5033
1002
Atpα-RF
FBtr0089514
NM_206527
4524
1002
Atpα-RG
FBtr0089515
NM_206526
4524
1002
Atpα-RH
FBtr0089516
NM_206525
4808
1002
Atpα-RI
FBtr0300191
NM_001170196
4524
1002
Atpα-RJ
FBtr0333324
NM_001275861
5545
1002
Atpα-RK
FBtr0333325
NM_001275862
3721
1002
Additional Transcript Data and Comments
Reported size (kB)
4.8, 3.8 (northern blot); 3.6 (unknown)
(Lebovitz et al., 1989)
6.5, 4.5, 4.2 (northern blot)
(Varadi et al., 1989)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
Atpα-PA
FBpp0088502
115.6
1041
5.40
NP_732572
AAF55825
Atpα-PB
FBpp0088503
111.1
1002
5.25
NP_732573
AAF55828
Atpα-PC
FBpp0088501
111.1
1002
5.25
NP_732574
AAF55827
Atpα-PD
FBpp0088504
92.0
839
5.33
NP_732575
AAF55826
Atpα-PE
FBpp0088984
111.1
1002
5.25
NP_996250
AAS65183
Atpα-PF
FBpp0088983
111.2
1002
5.20
NP_996249
AAS65184
Atpα-PG
FBpp0088982
111.3
1002
5.26
NP_996248
AAS65186
Atpα-PH
FBpp0088981
111.2
1002
5.20
NP_996247
AAS65185
Atpα-PI
FBpp0289428
111.2
1002
5.15
NP_001163667
ACZ94963
Atpα-PJ
FBpp0305516
111.1
1002
5.25
NP_001262790
AGB96170
Atpα-PK
FBpp0305517
111.1
1002
5.25
NP_001262791
AGB96171
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

1002 aa isoforms: Atpα-PB, Atpα-PC, Atpα-PE, Atpα-PJ, Atpα-PK
1002 aa isoforms: Atpα-PF, Atpα-PH
Additional Polypeptide Data and Comments
Reported size (kDa)
1038 (aa); 100 (kD observed)
(Lebovitz et al., 1989)
Comments
External Data
Subunit Structure (UniProtKB)
The sodium/potassium-transporting ATPase is composed of a catalytic alpha subunit, an auxiliary non-catalytic beta subunit and an additional regulatory subunit.
(UniProt, P13607)
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Nucleotide / Polypeptide Records
 
UniProt
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Atpα using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Gene Ontology (30 terms)
Molecular Function (3 terms)
Terms Based on Experimental Evidence (2 terms)
CV Term
Evidence
References
contributes_to cation transmembrane transporter activity
inferred from direct assay
(Sun et al., 1998)
sodium:potassium-exchanging ATPase activity
inferred from mutant phenotype
(Feng et al., 1997, Schubiger et al., 1994)
contributes_to sodium:potassium-exchanging ATPase activity
inferred from mutant phenotype
(Sun et al., 1998)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
ATP binding
inferred from electronic annotation with InterPro:IPR005775
(assigned by InterPro )
(FlyBase Curators et al., 2004-)
sodium:potassium-exchanging ATPase activity
inferred from biological aspect of ancestor with PANTHER:PTN000643123
(assigned by GO_Central )
(Gaudet et al., 2011)
inferred from sequence or structural similarity with RGD:2167
(Lebovitz et al., 1989)
Biological Process (20 terms)
Terms Based on Experimental Evidence (16 terms)
CV Term
Evidence
References
adult locomotory behavior
inferred from mutant phenotype
(Ashmore et al., 2009, Palladino et al., 2003)
cation transport
inferred from direct assay
(Sun et al., 1998, Feng et al., 1997)
chemical synaptic transmission
inferred from direct assay
(Trotta et al., 2004)
determination of adult lifespan
inferred from mutant phenotype
(Ashmore et al., 2009, Fergestad et al., 2006, Palladino et al., 2003)
jump response
inferred from mutant phenotype
(Ashmore et al., 2009)
locomotory behavior
inferred from mutant phenotype
(Sun et al., 2001)
neuromuscular process
inferred from mutant phenotype
(Palladino et al., 2003)
regulation of tube diameter, open tracheal system
inferred from mutant phenotype
(Hemphala et al., 2003, Paul et al., 2003)
regulation of tube length, open tracheal system
inferred from mutant phenotype
(Hemphala et al., 2003, Paul et al., 2003)
response to mechanical stimulus
inferred from mutant phenotype
(Palladino et al., 2003, Sun et al., 2001, Schubiger et al., 1994)
response to temperature stimulus
inferred from mutant phenotype
(Palladino et al., 2003, Feng et al., 1997)
sensory perception of sound
inferred from mutant phenotype
(Roy et al., 2013)
septate junction assembly
inferred from mutant phenotype
(Paul et al., 2003)
synaptic growth at neuromuscular junction
inferred from mutant phenotype
(Trotta et al., 2004)
tissue homeostasis
inferred from mutant phenotype
(Palladino et al., 2003)
trachea morphogenesis
inferred from mutant phenotype
(Ashmore et al., 2009)
Terms Based on Predictions or Assertions (4 terms)
CV Term
Evidence
References
cellular potassium ion homeostasis
inferred from biological aspect of ancestor with PANTHER:PTN000643123
(assigned by GO_Central )
(Gaudet et al., 2011)
cellular sodium ion homeostasis
inferred from biological aspect of ancestor with PANTHER:PTN000643123
(assigned by GO_Central )
(Gaudet et al., 2011)
potassium ion import across plasma membrane
inferred from biological aspect of ancestor with PANTHER:PTN000643123
(assigned by GO_Central )
(Gaudet et al., 2011)
sodium ion export across plasma membrane
inferred from biological aspect of ancestor with PANTHER:PTN000643123
(assigned by GO_Central )
(Gaudet et al., 2011)
Cellular Component (7 terms)
Terms Based on Experimental Evidence (5 terms)
CV Term
Evidence
References
basolateral plasma membrane
inferred from direct assay
(Yano et al., 2012, Torrie et al., 2004)
cytoplasm
inferred from high throughput direct assay
(Lee et al., 2014)
nucleus
inferred from direct assay
(Schubiger et al., 1994)
plasma membrane
inferred from high throughput direct assay
(Tan et al., 2009)
inferred from direct assay
(Roy et al., 2013, Clyne et al., 2003, Schubiger et al., 1994)
septate junction
inferred from direct assay
(Genova and Fehon, 2003, Paul et al., 2003)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
integral component of membrane
inferred from electronic annotation with InterPro:IPR001757, InterPro:IPR005775
(assigned by InterPro )
(FlyBase Curators et al., 2004-)
sodium:potassium-exchanging ATPase complex
inferred by curator from GO:0005391
(Sun et al., 1998)
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
microinjection
Stage
Tissue/Position (including subcellular localization)
Reference
larval stage
embryonic/larval midgut

Comment: enriched in acidic region

(Overend et al., 2016)
gastric caecum
(Overend et al., 2016)
northern blot
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage -- adult stage
(Lebovitz et al., 1989)
larval stage
Malpighian tubule
(Lebovitz et al., 1989)
embryonic/larval brain
(Lebovitz et al., 1989)
embryonic/larval salivary gland
(Lebovitz et al., 1989)
adult stage
abdomen
(Lebovitz et al., 1989)
thorax
(Lebovitz et al., 1989)
adult head
(Lebovitz et al., 1989)
head
(Lebovitz et al., 1989)
adult thorax
(Lebovitz et al., 1989)
Additional Descriptive Data
RNA-seq data show that Atpα is expressed throughout the larval midgut but is enriched in the acidic region of the larval midgut. It is also expressed in the gastric caecum.
(Overend et al., 2016)
Atpα transcripts are found in all body parts and stages examined by northern blots. The smaller transcripts are found in greater abundance than the larger transcript in adult abdomens, embryos, larval salivary glands, and larval Malpighian tubules and the reverse is true in the adult head and larval brain. The three transcripts are found at roughly equal abundance in the adult thorax.
(Lebovitz et al., 1989)
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
immunolocalization
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 16
epithelial cell of embryonic/larval salivary gland
(Paul et al., 2003)
embryonic/larval tracheocyte
(Paul et al., 2003)
epidermal cell
(Paul et al., 2003)
adult stage
Malpighian tubule
(Lebovitz et al., 1989)
indirect flight muscle
(Lebovitz et al., 1989)
tubular muscle
(Lebovitz et al., 1989)
retina
(Baumann et al., 2010, Lebovitz et al., 1989)
adult optic lobe

Comment: exhibits circadian cycling

(Baumann et al., 2010, Górska-Andrzejak et al., 2009, Lebovitz et al., 1989)
thoracico-abdominal ganglion
(Lebovitz et al., 1989)
adult brain
(Baumann et al., 2010, Lebovitz et al., 1989)
photoreceptor cell
(Lebovitz et al., 1989)
Johnston organ
(Roy et al., 2013)
Johnston organ neuron
(Roy et al., 2013)
lamina

Comment: exhibits circadian cycling

(Górska-Andrzejak et al., 2009)
medulla

Comment: exhibits circadian cycling

(Górska-Andrzejak et al., 2009)
glial cell | subset of lamina

Comment: exhibits circadian cycling

(Górska-Andrzejak et al., 2009)
ocellus retinula cell
(Mishra et al., 2012)
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
adult head
(Aradska et al., 2015)
day 7 of adulthood -- day 49 of adulthood
adult heart
(Cammarato et al., 2011)
Additional Descriptive Data
Atpα protein is expressed in the Johnston organ, with highest expression levels observed in the scolopale cells.
(Roy et al., 2013)
In retinula cells (photoreceptors) of ocelli, Atpα is restricted to membranes proximal to the rhabdomeres.
(Mishra et al., 2012)
Atpα is prominent in all areas of the brain including the optic lobes and the retina.
(Baumann et al., 2010)
Atpα protein is detected in the optic neuropil in both the lamina and the medulla and exhibits cirdacian cycling. Levels are highest at ZT13 and lowest at ZT16. The highest signal is in epithelial glial cells.
(Górska-Andrzejak et al., 2009)
Atpα protein shows high expression in Malpighian tubules, muscles and the nervous system (as assayed in adult sections with an antibody to avian sodium pump alpha subunit).
(Lebovitz et al., 1989)
Marker for
 
Subcellular Localization
CV Term
Evidence
References
basolateral plasma membrane
inferred from direct assay
(Yano et al., 2012, Torrie et al., 2004)
cytoplasm
inferred from high throughput direct assay
(Lee et al., 2014)
nucleus
inferred from direct assay
(Schubiger et al., 1994)
plasma membrane
inferred from high throughput direct assay
(Tan et al., 2009)
inferred from direct assay
(Roy et al., 2013, Clyne et al., 2003, Schubiger et al., 1994)
septate junction
inferred from direct assay
(Genova and Fehon, 2003, Paul et al., 2003)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\Atpα in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyBase Wiki
Image Based Resources
Alleles, Insertions, and Transgenic Constructs
Classical and Insertion Alleles ( 75 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 23 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of Atpα
Transgenic constructs containing regulatory region of Atpα
Deletions and Duplications ( 8 )
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
lethal
lethal, with Scer\GAL4btl.PS
lethal, with Scer\GAL4elav.PU
lethal, with Scer\GAL4nrv1.PS
lethal, with Scer\GAL4repo.PU
lethal (with AtpαCJ4)
lethal (with AtpαCJ5)
lethal (with AtpαCJ6)
lethal (with AtpαCJ10)
lethal (with AtpαCJ12)
lethal (with AtpαCJ13)
lethal (with AtpαDTS1R1)
lethal (with AtpαDTS2R3)
lethal | embryonic stage
lethal | embryonic stage | recessive
lethal | embryonic stage | rescuable maternal effect
lethal | heat sensitive (with AtpαCJ6)
lethal | heat sensitive (with AtpαCJ7)
lethal | heat sensitive (with AtpαCJ12)
lethal | heat sensitive (with AtpαCJ13)
lethal | recessive
lethal | recessive | cold sensitive
lethal - all die before end of embryonic stage
lethal - all die before end of embryonic stage (with Atpα01453a)
lethal - all die before end of embryonic stage (with Atpα2206)
lethal - all die before end of embryonic stage (with AtpαDTS1)
lethal - all die before end of embryonic stage (with AtpαDTS1R1)
lethal - all die before end of embryonic stage (with AtpαDTS1R2)
lethal - all die before end of embryonic stage (with AtpαDTS2)
lethal - all die before end of embryonic stage (with AtpαDTS2R1)
lethal - all die before end of embryonic stage (with AtpαDTS2R2)
lethal - all die before end of embryonic stage (with AtpαDTS2R3)
lethal - all die before end of embryonic stage (with AtpαH64)
lethal - all die before end of embryonic stage | recessive
lethal - all die before end of pupal stage, with Scer\GAL4pnr-MD237
lethal - all die before end of pupal stage (with Atpα2206)
lethal - all die before end of pupal stage (with AtpαDTS2)
lethal - all die during P-stage, with Scer\GAL4Mef2.PR
partially lethal, with Scer\GAL4nrv2.PS
partially lethal - majority die (with Atpα01453a)
partially lethal - majority die (with AtpαCJ4)
partially lethal - majority die (with AtpαCJ7)
partially lethal - majority die (with AtpαCJ12)
partially lethal - majority die (with AtpαDTS1)
partially lethal - majority die (with AtpαDTS2)
partially lethal - majority die | heat sensitive (with AtpαCJ5)
partially lethal - majority die | heat sensitive (with AtpαCJ7)
partially lethal - majority die | heat sensitive (with AtpαCJ10)
partially lethal - majority die | heat sensitive (with AtpαCJ12)
partially lethal - majority die | heat sensitive (with AtpαCJ13)
partially lethal - majority live (with Atpα01453a)
partially lethal - majority live (with Atpα2206)
viable
viable, with Dcr-2UAS.cDa, Scer\GAL4elav.PLu
viable, with Scer\GAL4tin.CΔ4
viable (with AtpαCJ5)
viable (with AtpαCJ6)
viable (with AtpαCJ7)
viable (with AtpαCJ10)
viable (with AtpαCJ12)
viable (with AtpαCJ13)
Sterility
Allele
fertile
Other Phenotypes
Allele
auditory perception defective, with Scer\GAL4ato.PU
auditory perception defective, with Scer\GAL4nompA.cK
bang sensitive
bang sensitive (with Atpα2206)
bang sensitive (with AtpαCJ4)
bang sensitive (with AtpαCJ6)
bang sensitive (with AtpαCJ7)
bang sensitive (with AtpαCJ12)
bang sensitive (with AtpαCJ13)
bang sensitive (with AtpαDTS1)
bang sensitive (with AtpαDTS1R1)
bang sensitive (with AtpαDTS2R3)
bang sensitive | adult stage | progressive, with Scer\GAL4repo
bang sensitive | dominant
bang sensitive | dominant | heat sensitive
bang sensitive | dominant | progressive
bang sensitive | dominant | progressive | heat sensitive
bang sensitive | heat sensitive
bang sensitive | heat sensitive, with Atpα2206
bang sensitive | heat sensitive, with AtpαD369N.hs
bang sensitive | heat sensitive (with AtpαCJ5)
bang sensitive | heat sensitive (with AtpαCJ7)
bang sensitive | heat sensitive (with AtpαCJ10)
bang sensitive | heat sensitive (with AtpαCJ12)
bang sensitive | recessive | cold sensitive
behavior defective, with Scer\GAL4nrv2.PS
chemical resistant, with Scer\GAL4nrv2.PS
chemical resistant | heat sensitive
chemical sensitive
chemical sensitive, with Scer\GAL4nrv2.PS
chemical sensitive | heat sensitive
chemical sensitive | heat sensitive, with Atpα2206
chemical sensitive | heat sensitive, with AtpαD369N.hs
circadian behavior defective | adult stage, with Scer\GAL4P2.4.Pdf
hypoactive
hypoactive | heat sensitive
hypoactive | heat sensitive, with Atpα2206
hypoactive | heat sensitive, with AtpαD369N.hs
increased cell death | adult stage | progressive, with Scer\GAL4GMR.long
locomotor behavior defective | adult stage
locomotor behavior defective | dominant
locomotor behavior defective | recessive
locomotor rhythm defective | dominant
long lived | dominant
neuroanatomy defective
neuroanatomy defective | adult stage | dominant
neuroanatomy defective | adult stage | recessive
neuroanatomy defective | dominant
neurophysiology defective
neurophysiology defective | adult stage, with Scer\GAL4GMR.long
neurophysiology defective | adult stage, with Scer\GAL4GMR.PF
neurophysiology defective | heat sensitive
neurophysiology defective | larval stage, with Scer\GAL4futsch-C380
optomotor response defective, with Scer\GAL4GMR.long
paralytic
paralytic | conditional
paralytic | dominant
paralytic | dominant | heat sensitive
paralytic | heat sensitive
paralytic | heat sensitive (with Atpα01453a)
paralytic | heat sensitive (with Atpα2206)
paralytic | heat sensitive (with AtpαDTS1)
paralytic | heat sensitive (with AtpαDTS2)
phototaxis defective | adult stage, with Scer\GAL4GMR.long
phototaxis defective | recessive
short lived
short lived | dominant
some die during embryonic stage
some die during embryonic stage (with Atpα01453a)
some die during embryonic stage (with Atpα2206)
some die during embryonic stage (with AtpαDTS1)
some die during embryonic stage (with AtpαDTS1R1)
some die during embryonic stage (with AtpαDTS1R2)
some die during embryonic stage (with AtpαDTS2)
some die during embryonic stage (with AtpαDTS2R1)
some die during embryonic stage (with AtpαDTS2R2)
some die during embryonic stage (with AtpαDTS2R3)
some die during embryonic stage (with AtpαH64)
some die during embryonic stage | recessive
some die during pupal stage, with Scer\GAL4pnr-MD237
some die during pupal stage (with Atpα2206)
some die during pupal stage (with AtpαDTS2)
Phenotype manifest in
Allele
adult brain
dorsal medial indirect flight muscle
dorsal trunk primordium
dorsal trunk primordium | embryonic stage 14
embryonic/first instar larval cuticle
embryonic/larval dorsal trunk
embryonic/larval ganglionic branch
embryonic segment
embryonic somatic muscle
eye, with Scer\GAL4GMR.long
eye, with Scer\GAL4GMR.PF
eye photoreceptor cell, with Scer\GAL4GMR.long
flight muscle
ganglionic branch primordium
giant fiber neuron, with Scer\GAL4GMR.long
Johnston organ, with Scer\GAL4nompA.cK
Malpighian tubule
neuromuscular junction
NMJ bouton | supernumerary
ommatidium, with Scer\GAL4GMR.long
presumptive embryonic/larval tracheal system
presumptive embryonic salivary gland
rhabdomere of eye photoreceptor cell | progressive, with Scer\GAL4GMR.long
segment
septate junction
thoracico-abdominal ganglion
tracheal branch primordium
Orthologs
Downloads
Download All DIOPT Orthologs
Download All OrthoDB Orthologs
Human Orthologs (via DIOPT v7.1)
Homo sapiens (Human) (6)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Hsap\ATP1A1
13 of 15
Yes
Yes
Hsap\ATP1A3
13 of 15
Yes
Yes
 
Hsap\ATP1A2
11 of 15
No
Yes
Hsap\ATP1A4
8 of 15
No
Yes
Hsap\ATP12A
7 of 15
No
Yes
Hsap\ATP4A
6 of 15
No
Yes
Model Organism Orthologs (via DIOPT v7.1)
Mus musculus (laboratory mouse) (6)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Mmus\Atp1a3
14 of 15
Yes
Yes
Mmus\Atp1a1
13 of 15
No
Yes
Mmus\Atp1a2
11 of 15
No
Yes
Mmus\Atp1a4
9 of 15
No
Yes
Mmus\Atp12a
7 of 15
No
Yes
Mmus\Atp4a
5 of 15
No
Yes
Rattus norvegicus (Norway rat) (6)
Rnor\Atp1a1
11 of 13
Yes
Yes
 
 
Rnor\Atp1a2
9 of 13
No
Yes
Rnor\Atp1a3
9 of 13
No
Yes
Rnor\Atp12a
7 of 13
No
Yes
Rnor\Atp1a4
6 of 13
No
Yes
Rnor\Atp4a
5 of 13
No
Yes
Xenopus tropicalis (Western clawed frog) (5)
Xtro\atp1a3
8 of 12
Yes
Yes
Xtro\atp1a1
7 of 12
No
Yes
Xtro\atp1a2
7 of 12
No
Yes
Xtro\atp12a-like
4 of 12
No
Yes
Xtro\atp4a
3 of 12
No
Yes
Danio rerio (Zebrafish) (9)
Drer\atp1a3a
14 of 15
Yes
Yes
Drer\atp1a1a.1
12 of 15
No
Yes
Drer\atp1a1a.2
9 of 15
No
Yes
Drer\atp1a1a.4
8 of 15
No
Yes
Drer\atp1a1b
8 of 15
No
Yes
Drer\atp1a2a
8 of 15
No
Yes
Drer\atp1a1a.3
7 of 15
No
Yes
Drer\atp1a1a.5
7 of 15
No
Yes
Drer\atp1a3b
6 of 15
No
Yes
Caenorhabditis elegans (Nematode, roundworm) (5)
Cele\eat-6
13 of 15
Yes
Yes
Cele\catp-3
4 of 15
No
No
Cele\catp-2
3 of 15
No
No
Cele\catp-4
3 of 15
No
No
Cele\catp-1
2 of 15
No
No
Arabidopsis thaliana (thale-cress) (0)
No records found.
Saccharomyces cerevisiae (Brewer's yeast) (5)
Scer\ENA1
1 of 15
Yes
No
Scer\ENA2
1 of 15
Yes
No
Scer\ENA5
1 of 15
Yes
No
Scer\PMA1
1 of 15
Yes
Yes
Scer\PMR1
1 of 15
Yes
No
Schizosaccharomyces pombe (Fission yeast) (1)
Spom\cta3
1 of 12
Yes
No
Orthologs in Drosophila Species (via OrthoDB v9.1) ( EOG091901EL )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila melanogaster
fruit fly
Dmel\Atpα
Drosophila suzukii
Spotted wing Drosophila
Dsuz\DS10_00009030
Drosophila simulans
Dsim\GD19388
Drosophila sechellia
Dsec\GM15055
Drosophila erecta
Dere\GG24266
Drosophila yakuba
Dyak\GE25699
Drosophila ananassae
Dana\GF17998
Drosophila pseudoobscura pseudoobscura
Dpse\GA19046
Drosophila persimilis
Dper\GL24291
Drosophila willistoni
Dwil\GK11950
Drosophila virilis
Dvir\GJ10697
Drosophila mojavensis
Dmoj\GI10755
Drosophila grimshawi
Dgri\GH21713
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG091500TG )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Mdoa\17012568
Glossina morsitans
Tsetse fly
Gmor\GMOY003579
Lucilia cuprina
Australian sheep blowfly
Lcup\FF38_14114
Mayetiola destructor
Hessian fly
Mdes\Mdes001311
Aedes aegypti
Yellow fever mosquito
Aaeg\AAEL012062
Anopheles darlingi
American malaria mosquito
Adar\ADAC005766
Anopheles gambiae
Malaria mosquito
Agam\AGAP002858
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ005966
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W00OH )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Bombyx mori
Silkmoth
Bmor\BGIBMGA005058
Danaus plexippus
Monarch butterfly
Dple\DPOGS214640-PA
Heliconius melpomene
Postman butterfly
Hmel\HMEL005691
Apis florea
Little honeybee
Aflo\2157450900
Apis mellifera
Western honey bee
Amel\GB42054
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP10181
Bombus terrestris
Buff-tailed bumblebee
Bter\15216345
Linepithema humile
Argentine ant
Lhum\LH21769
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:001d88
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG012301
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_11557
Tribolium castaneum
Red flour beetle
Tcas\TC033838
Pediculus humanus
Human body louse
Phum\PHUM336910
Pediculus humanus
Human body louse
Phum\PHUM361900
Rhodnius prolixus
Kissing bug
Rpro\RPRC000444
Cimex lectularius
Bed bug
Clec\CLEC006776
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI008640
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_11385
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X00OF )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strigamia maritima
European centipede
Smar\SMAR009306
Strigamia maritima
European centipede
Smar\SMAR006718
Strigamia maritima
European centipede
Smar\SMAR006716
Ixodes scapularis
Black-legged tick
Isca\ISCW002538
Stegodyphus mimosarum
African social velvet spider
Smim\KFM73790.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM68400.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM80606.1
Tetranychus urticae
Two-spotted spider mite
Turt\tetur08g05620
Tetranychus urticae
Two-spotted spider mite
Turt\tetur27g01220
Tetranychus urticae
Two-spotted spider mite
Turt\tetur01g07010
Tetranychus urticae
Two-spotted spider mite
Turt\tetur08g05230
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_202800
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_305634
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_256165
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_305693
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G01BB )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Atp1a3
Ciona intestinalis
Vase tunicate
Cint\LOC100175029
Gallus gallus
Domestic chicken
Ggal\ATP12A
Gallus gallus
Domestic chicken
Ggal\ATP1A1
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v7.1)
Drosophila melanogaster (Fruit fly) (5)
Gene Symbol
Score
Source
Compara
eggNOG
Homologene
Inparanoid
Isobase
OrthoDB
OrthoFinder
orthoMCL
Panther
RoundUp
Alignment
JYalpha
5 of 10
CG45062
2 of 10
CG45063
1 of 10
SERCA
1 of 10
SPoCk
1 of 10
Human Disease Associations
FlyBase Human Disease Model Reports
Disease Model Summary Ribbon
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 6 )
Potential Models Based on Orthology ( 4 )
Modifiers Based on Experimental Evidence ( 0 )
Allele
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease Associations of Human Orthologs (via DIOPT v7.1 and OMIM)
Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
Homo sapiens (Human)
Gene name
Score
OMIM
OMIM Phenotype
DO term
Complementation?
Transgene?
ATP1A1; ATPase Na+/K+ transporting subunit alpha 1
13 of 15
182310
    ATP1A3; ATPase Na+/K+ transporting subunit alpha 3
    13 of 15
    182350
     
    ATP1A2; ATPase Na+/K+ transporting subunit alpha 2
    11 of 15
    182340
    ATP1A4; ATPase Na+/K+ transporting subunit alpha 4
    8 of 15
    607321
        ATP12A; ATPase H+/K+ transporting non-gastric alpha2 subunit
        7 of 15
        182360
            ATP4A; ATPase H+/K+ transporting subunit alpha
            6 of 15
            137216
                Functional Complementation Data
                Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
                Dmel gene
                Ortholog showing functional complementation
                Supporting References
                Atpα
                Rnor\Atp1a1
                (Paul et al., 2007)
                Interactions
                Summary of Physical Interactions
                esyN Network Diagram
                Show neighbor-neighbor interactions:
                Select Layout:
                Legend:
                Protein
                RNA
                Selected Interactor(s)
                Interactions Browser
                View in Interactions Browser
                Please see the Physical Interaction reports below for full details
                protein-protein
                Physical Interaction
                Assay
                References
                Atpα - Akt1
                anti tag coimmunoprecipitation, Identification by mass spectrometry
                (Vinayagam et al., 2016)
                Atpα - CG33303
                experimental knowledge based
                (Guruharsha et al., 2011)
                Atpα - Chc
                experimental knowledge based
                (Guruharsha et al., 2011)
                Atpα - Hel25E
                experimental knowledge based
                (Guruharsha et al., 2011)
                Atpα - Kap-α3
                experimental knowledge based
                (Guruharsha et al., 2011)
                Atpα - Karyβ3
                experimental knowledge based
                (Guruharsha et al., 2011)
                Atpα - MRP
                experimental knowledge based
                (Guruharsha et al., 2011)
                Atpα - Mcad
                experimental knowledge based
                (Guruharsha et al., 2011)
                Atpα - Mec2
                experimental knowledge based
                (Guruharsha et al., 2011)
                Atpα - Ost48
                experimental knowledge based
                (Guruharsha et al., 2011)
                Atpα - OstΔ
                experimental knowledge based
                (Guruharsha et al., 2011)
                Atpα - Past1
                experimental knowledge based
                (Guruharsha et al., 2011)
                Atpα - Rab1
                experimental knowledge based
                (Guruharsha et al., 2011)
                Atpα - Ranbp9
                experimental knowledge based
                (Guruharsha et al., 2011)
                Atpα - SERCA
                experimental knowledge based
                (Guruharsha et al., 2011)
                Atpα - Sc2
                experimental knowledge based
                (Guruharsha et al., 2011)
                Atpα - Scamp
                experimental knowledge based
                (Guruharsha et al., 2011)
                Atpα - Sec61α
                experimental knowledge based
                (Guruharsha et al., 2011)
                Atpα - UQCR-C2
                experimental knowledge based
                (Guruharsha et al., 2011)
                Atpα - Ube3a
                enzymatic study, western blot
                (Jensen et al., 2013)
                Atpα - Vha68-2
                experimental knowledge based
                (Guruharsha et al., 2011)
                Atpα - ZnT63C
                experimental knowledge based
                (Guruharsha et al., 2011)
                Atpα - gig
                anti tag coimmunoprecipitation, Identification by mass spectrometry
                (Vinayagam et al., 2016)
                Atpα - mats
                anti tag coimmunoprecipitation, peptide massfingerprinting
                (Kwon et al., 2013)
                Atpα - nrv2
                experimental knowledge based
                (Guruharsha et al., 2011)
                Atpα - spidey
                experimental knowledge based
                (Guruharsha et al., 2011)
                Atpα - wal
                experimental knowledge based
                (Guruharsha et al., 2011)
                Atpα - yki
                anti tag coimmunoprecipitation, peptide massfingerprinting
                (Kwon et al., 2013)
                Summary of Genetic Interactions
                esyN Network Diagram
                esyN Network Key:
                Suppression
                Enhancement
                View in Interactions Browser
                Please look at the allele data for full details of the genetic interactions
                Starting gene(s)
                Interaction type
                Interacting gene(s)
                Reference
                Atpα
                enhanceable
                para
                (Fergestad et al., 2006)
                Atpα
                suppressible
                para
                (Trotta et al., 2004)
                Atpα
                suppressible
                sesB
                (Trotta et al., 2004)
                Starting gene(s)
                Interaction type
                Interacting gene(s)
                Reference
                para
                enhanceable
                Atpα
                (Fergestad et al., 2006)
                sesB
                suppressible
                Atpα
                (Trotta et al., 2004)
                Ube3a
                suppressible
                Atpα
                (Hope et al., 2017)
                External Data
                Subunit Structure (UniProtKB)
                The sodium/potassium-transporting ATPase is composed of a catalytic alpha subunit, an auxiliary non-catalytic beta subunit and an additional regulatory subunit.
                (UniProt, P13607 )
                Linkouts
                BioGRID - A database of protein and genetic interactions.
                DroID - A comprehensive database of gene and protein interactions.
                InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
                MIST (protein-protein) - An integrated Molecular Interaction Database
                Pathways
                Gene Group - Pathway Membership (FlyBase)
                External Data
                Linkouts
                Genomic Location and Detailed Mapping Data
                Chromosome (arm)
                3R
                Recombination map
                3-69
                Cytogenetic map
                93A4-93A4
                Sequence location
                3R:20,948,714..20,976,239 [+]
                FlyBase Computed Cytological Location
                Cytogenetic map
                Evidence for location
                93A4-93A4
                Limits computationally determined from genome sequence between P{EP}SyndEP409 and P{lacW}l(3)j5C7j5C7
                Experimentally Determined Cytological Location
                Cytogenetic map
                Notes
                References
                93A7-93B1
                (determined by in situ hybridisation)
                (Ranz et al., 2001)
                93B2-93B2
                (Sun, 1998.1.25)
                93B-93B
                (determined by in situ hybridisation)
                (Feng et al., 1997, Lebovitz et al., 1989)
                93B1-93B2
                (determined by in situ hybridisation)
                (Spradling et al., 1999, Perrimon et al., 1996, Schwarz, 1996, Schubiger et al., 1994, Berg and Spradling, 1991)
                93B1-93B2
                93B1--3 93B2--3
                (BDGP Project Members, 1994-1999)
                Experimentally Determined Recombination Data
                Location
                3-69
                (FlyBase, 2016)
                3-73.4
                (Comeron et al., 2012)
                Left of (cM)
                Right of (cM)
                Notes
                Stocks and Reagents
                Stocks (29)
                Genomic Clones (31)
                cDNA Clones (194)
                 

                Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

                cDNA clones, fully sequences
                BDGP DGC clones
                Other clones
                Drosophila Genomics Resource Center cDNA clones

                For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

                cDNA Clones, End Sequenced (ESTs)
                BDGP DGC clones
                Other clones
                RNAi and Array Information
                Linkouts
                DRSC - Results frm RNAi screens
                GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
                Antibody Information
                Laboratory Generated Antibodies
                 
                Commercially Available Antibodies
                 
                Developmental Studies Hybridoma Bank - Monoclonal antibodies for use in research
                Other Information
                Relationship to Other Genes
                Source for database identify of
                Source for database merge of
                Source for merge of: Atpα l(3)04492
                (Beaton, 1999.12.12)
                Source for merge of: Atpα CG5670
                (Bayraktaroglu, 2000.4.13)
                Additional comments
                Other Comments
                Mutant embryos have lengthened primary tracheal tubes with expanded diameters, and defective septate junctions.
                (Paul et al., 2003)
                Analysis of the conserved core sequence in 159 P-type ATPases from the 3 domains of life (Archaea, Bacteria and Eukarya) establishes 5 major groups of P-type ATPases.
                (Axelsen and Palmgren, 1998)
                The genomic organisation of the Atpα locus has been characterised.
                (Feng et al., 1997)
                The autosomal "FLP-DFS" technique (using the P{ovoD1-18} P{FRT(whs)} P{hsFLP} chromosomes) has been used to identify the specific maternal effect phenotype for the zygotic lethal mutation.
                (Perrimon et al., 1996)
                Atpα and l(3)01453 are likely to be the same gene but it is not yet proven.
                (Schwarz, 1996)
                Structural gene for the α or catalytic subunit of Na+ K+ ATPase (ouabain sensitive). Immunofluorescence microscopy with a monoclonal antibody demonstrates high concentrations of αATPase in adult muscle, nervous tissue and Malpighian tubules; strong immunofluorescence observed in brain, optic lobes, photoreceptor cells of retina and ventral thoracic neuromere.
                Flies heterozygous for Hypomorphic mutant alleles show a bang-sensitive phenotype and are lethargic. Haplo-insufficient - flies heterozygous for a complete deletion are sluggish and less tolerant of physical stress than normal.
                Origin and Etymology
                Discoverer
                Etymology
                Identification
                External Crossreferences and Linkouts ( 102 )
                Sequence Crossreferences
                NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
                GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
                GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
                RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
                UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
                UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
                Other crossreferences
                Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
                Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
                Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
                Flygut - An atlas of the Drosophila adult midgut
                GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
                iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
                InterPro - A database of protein families, domains and functional sites
                KEGG Genes - Molecular building blocks of life in the genomic space.
                modMine - A data warehouse for the modENCODE project
                Linkouts
                ApoDroso - Functional genomic database for photoreceptor development, survival and function
                BioGRID - A database of protein and genetic interactions.
                DroID - A comprehensive database of gene and protein interactions.
                DRSC - Results frm RNAi screens
                Developmental Studies Hybridoma Bank - Monoclonal antibodies for use in research
                FLIGHT - Cell culture data for RNAi and other high-throughput technologies
                FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
                FlyMine - An integrated database for Drosophila genomics
                Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
                InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
                MIST (protein-protein) - An integrated Molecular Interaction Database
                Synonyms and Secondary IDs (76)
                Reported As
                Symbol Synonym
                (Na+/k+)-ATPase
                (Verma and Tapadia, 2014)
                ATP-alpha
                (Zhang et al., 2013)
                ATP-α
                (Lee et al., 2014)
                ATPBagr
                (Nakahara and Carthew, 2004)
                ATPa
                (Paul et al., 2003)
                ATPalpha
                (Aw et al., 2017, Talsma et al., 2014, Caldwell et al., 2013, Liu et al., 2012, Ashmore et al., 2009, Palladino and Miller, 2007, Paul et al., 2005, Wu and Beitel, 2004, Anholt et al., 2003, Clyne et al., 2003, Palladino and Johnston, 2003, Palladino et al., 2003, Palladino et al., 2003)
                ATPα
                (Yang et al., 2019, Dalla et al., 2017, Hope et al., 2017, Matsushima et al., 2017, Overend et al., 2016, de Madrid et al., 2015, Gautam et al., 2015, Jensen et al., 2013, Roy et al., 2013, Gistelinck et al., 2012, Franco et al., 2011, Jayanandanan et al., 2011, Nilton et al., 2010, Tiklová et al., 2010, Górska-Andrzejak et al., 2009, Fergestad et al., 2008, Nicholson et al., 2008, Blard et al., 2007, Wu et al., 2004, Ghabrial et al., 2003, Paul et al., 2003)
                Atp
                (Neuert et al., 2017)
                Atp a
                (Trotta et al., 2003)
                Atpa
                (Yang et al., 2004)
                Atpalpha
                (Kuznetsova et al., 2018, Wang et al., 2018, Kline et al., 2017, Transgenic RNAi Project members, 2017-, Clandinin and Owens, 2016-, Lee et al., 2016, Aradska et al., 2015, Chen et al., 2015, Gene Disruption Project members, 2015-, Ramirez et al., 2015, Van Bortle et al., 2015, Ashwal-Fluss et al., 2014, Kwon et al., 2013, Kwon et al., 2013, Schertel et al., 2013, Japanese National Institute of Genetics, 2012.5.21, Rodriguez et al., 2012, Friedman et al., 2011, Seong et al., 2011, Christensen et al., 2009.6.15, Tan et al., 2009, Buszczak et al., 2007, Quinones-Coello, 2007, Molnar et al., 2006, Laviolette et al., 2005, Wang et al., 2004, Watson et al., 2001)
                Atpα
                (Sakakibara et al., 2018, Aigouy and Le Bivic, 2016, DeSalvo et al., 2014, Luan et al., 2014, Van Vranken et al., 2014, Chen and Zhang, 2013, Jaiswal et al., 2012, Paik et al., 2012, Baumann et al., 2010, Nelson et al., 2010, Nilton et al., 2010, Chew et al., 2009, Laprise et al., 2009, Loevenich et al., 2009, Jayaram et al., 2008, Kapelnikov et al., 2008, Paul et al., 2007, Stapleton et al., 2006, Wang et al., 2006, Tonning et al., 2005, Trotta et al., 2004)
                CG5670
                (Kolkhof et al., 2017, Neuert et al., 2017, Çiçek et al., 2016, Aradska et al., 2015, Hosono et al., 2015, Jensen et al., 2013, Schertel et al., 2013, Christis and Munro, 2012, Jaspers et al., 2012, Yano et al., 2012, Cammarato et al., 2011, Khanna et al., 2010, Ni et al., 2010.12.1, Keleman et al., 2009.8.5, Loevenich et al., 2009, Perkins et al., 2009, Quinones-Coello, 2007, Molnar et al., 2006, Laviolette et al., 2005, Brody et al., 2002, Labourier et al., 2002)
                Da-47
                (Lebovitz, 1995.3.21)
                JY
                NKA
                (D'Silva et al., 2017)
                Na+-K+-ATPase
                (Satoh et al., 2002)
                Na+/K+ ATPase alpha subunit
                (Sun, 1998.1.25)
                Na+/K+-ATPase
                (Choubey and Roy, 2017, D'Silva et al., 2017)
                Na,K ATPase
                (Dubreuil et al., 1999)
                Na,K-ATPase
                (Okamura et al., 2001, Baumann et al., 1999, Bohrmann and Braun, 1999)
                Na-p
                Na/K ATPase
                (Peterson and Krasnow, 2015)
                Na/K-ATPase
                (Muller, 2000)
                Na/K-ATPase alpha-subunit
                (Feng, 1996.4.18)
                Na/K-ATPase α-subunit
                (Yasuhara et al., 2000)
                Na+, K+ -ATPase
                (Cereijido et al., 2003)
                Na+,K+-ATPase
                (Tepass et al., 2001)
                Na+,K+-ATPase α subunit
                (Sun et al., 2001)
                Na+,K+-ATPase α-subunit
                (Baumann, 2001, Sun et al., 1998, Sun and Salvaterra, 1995)
                Na+-K+-ATPase α5-subunit
                (Sciortino et al., 2001)
                Na+/K+ ATPase
                (Chen and Haddad, 2004)
                Na+/K+-ATPase
                (Linton and O'Donnell, 1999)
                Na+/K+ATPase
                (Chen et al., 2002)
                Na+K+ ATPase
                (Moyer and Jacobs, 2008)
                Na+K+-ATPase
                (Satoh et al., 2013)
                Na+K+ATPase
                (Iwanami et al., 2016, Müller and Bossinger, 2003)
                NaK
                (Satoh et al., 2013, Li et al., 2007)
                NaK ATPase
                (Wu and Beitel, 2003)
                NaK-ATPase
                (Tepass, 2012)
                atpalpha
                (Chintapalli et al., 2013)
                atpα
                (Chen et al., 2012)
                dnATPase
                (Parisky et al., 2008)
                l(3)01164
                (Russell et al., 1998, Perrimon et al., 1996)
                l(3)01453
                l(3)04492
                (Lee et al., 1993)
                l(3)j3B2
                l(3)j3B7
                l(3)j6A4
                l(3)rM454
                l(3)ry136
                sodium/potassium transporting ATPase alpha
                (Varadi, 1995.2.23)
                α-ATPase
                (Wang et al., 2018)
                Name Synonyms
                (Na+ + K+)-ATPase α-subunit
                (Lebovitz et al., 1989)
                (Na+,K+)ATPase α subunit
                (Schubiger et al., 1994)
                ATPalpha
                (Gohl et al., 2014)
                ATPase α
                (Schulte et al., 2006)
                ATPase α subunit
                (Schubiger et al., 1994)
                Atpalpha
                (Giot et al., 2003, Spradling et al., 1999)
                Na pump alpha subunit
                (Jaspers et al., 2012, Cammarato et al., 2011, Tan et al., 2009)
                Na pump α subunit
                (Chen and Zhang, 2013, Yano et al., 2012)
                Na+,K+ ATPase alpha-subunit
                (Lebovitz, 1995.3.21)
                Na, K ATPase a subunit
                (Robinson et al., 2010)
                Na,K ATPase
                (Baumann et al., 2010)
                Na,K ATPase α subunit
                (Dubreuil et al., 2000)
                Na,K-ATPase
                (Laprise et al., 2008)
                Na,K-ATPase alpha
                (Dalla et al., 2013)
                Na,K-ATPase α subunit
                (Dubreuil et al., 1997, Feng et al., 1997)
                Na,K-ATPase α-subunit
                (Dobler et al., 2012, Feng et al., 1997)
                Na<up> +</up> , K<up> +</up> -ATPase
                (Yano et al., 2012)
                Na+ pump α subunit
                (Kapelnikov et al., 2008)
                Na+, K+ ATPase alpha
                (Ashmore et al., 2009)
                Na+,K+ ATPase α subunit
                (Torrie et al., 2004)
                Na+,K+-ATPase α subunit
                (Sun et al., 1998)
                Na+-K+ ATPase
                (Li et al., 2007)
                Na+/K+ ATPase (α subunit)
                (Khanna et al., 2010)
                Na+/K+ ATPase alpha subunit
                (Pulver and Griffith, 2010)
                Na+K+ ATPase alpha subunit
                (Wightman et al., 2012)
                Na+K+ATPase
                (Satoh et al., 2015)
                NaK-ATPase
                (Laprise and Tepass, 2011)
                Sodium pump alpha subunit
                (Khanna et al., 2010)
                sodium pump α-subunit
                (Górska-Andrzejak et al., 2009)
                α-subunit of ATPase
                (Lee et al., 1993)
                Secondary FlyBase IDs
                • FBgn0004667
                • FBgn0010739
                • FBgn0010749
                • FBgn0011344
                • FBgn0011348
                • FBgn0011389
                • FBgn0011518
                • FBgn0014319
                • FBgn0024511
                • FBgn0038844
                Datasets (0)
                Study focus (0)
                Experimental Role
                Project
                Project Type
                Title
                References (263)