Na,K-ATPase, Na+K+ATPase, Na pump alpha subunit, l(3)01164, Na+,K+-ATPase α-subunit
ion pump responsible for the cellular balance of sodium and potassium ions - regulation of neuronal excitability and auditory mechanosensation - epithelial junction function - tracheal tube-size control - septate junction function - neurodegeneration - muscles - malpighian tubules
Low-frequency RNA-Seq exon junction(s) not annotated.
Annotated transcripts do not represent all supported alternative splices within 5' UTR.
Annotated transcripts do not represent all possible combinations of alternative exons and/or alternative promoters.
Gene model reviewed during 5.46
Gene model reviewed during 5.55
1038 (aa); 100 (kD observed)
The sodium/potassium-transporting ATPase is composed of a catalytic alpha subunit, an auxiliary non-catalytic beta subunit and an additional regulatory subunit.
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Atpα using the Feature Mapper tool.
RNA-seq data show that Atpα is expressed throughout the larval midgut but is enriched in the acidic region of the larval midgut. It is also expressed in the gastric caecum.
Atpα transcripts are found in all body parts and stages examined by northern blots. The smaller transcripts are found in greater abundance than the larger transcript in adult abdomens, embryos, larval salivary glands, and larval Malpighian tubules and the reverse is true in the adult head and larval brain. The three transcripts are found at roughly equal abundance in the adult thorax.
Comment: exhibits circadian cycling
Atpα protein is expressed in the Johnston organ, with highest expression levels observed in the scolopale cells.
In retinula cells (photoreceptors) of ocelli, Atpα is restricted to membranes proximal to the rhabdomeres.
Atpα is prominent in all areas of the brain including the optic lobes and the retina.
Atpα protein is detected in the optic neuropil in both the lamina and the medulla and exhibits cirdacian cycling. Levels are highest at ZT13 and lowest at ZT16. The highest signal is in epithelial glial cells.
GBrowse - Visual display of RNA-Seq signalsView Dmel\Atpα in GBrowse 2
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Mutant embryos have lengthened primary tracheal tubes with expanded diameters, and defective septate junctions.
Analysis of the conserved core sequence in 159 P-type ATPases from the 3 domains of life (Archaea, Bacteria and Eukarya) establishes 5 major groups of P-type ATPases.
Structural gene for the α or catalytic subunit of Na+ K+ ATPase (ouabain sensitive). Immunofluorescence microscopy with a monoclonal antibody demonstrates high concentrations of αATPase in adult muscle, nervous tissue and Malpighian tubules; strong immunofluorescence observed in brain, optic lobes, photoreceptor cells of retina and ventral thoracic neuromere.
Flies heterozygous for Hypomorphic mutant alleles show a bang-sensitive phenotype and are lethargic. Haplo-insufficient - flies heterozygous for a complete deletion are sluggish and less tolerant of physical stress than normal.