FlyBase Gene Report: Dmel\ncd

General Information

Symbol

Dmel\ncd

Species

D. melanogaster

Name

non-claret disjunctional

Annotation Symbol

CG7831

Feature Type

protein_coding_gene

FlyBase ID

FBgn0002924

Gene Model Status

Current

Stock Availability

21 publicly available

Enzyme Name (EC)

Adenosinetriphosphatase (3.6.1.3)

Minus-end-directed kinesin ATPase (3.6.4.5)

Gene Snapshot

Non-claret disjunctional is a minus-end-directed kinesin microtubule motor protein and the sole member of the kinesin-14 motor family. It is required for spindle assembly in oocytes and chromosome attachment to spindles in early embryos. [Date last reviewed: 2016-06-23]

Other Summaries

Auto summary
Gene Group
UniProtKB
Red Book
Interactive Fly

Also Known As

DmNcd, l(3)05884, ca^nd

Key Links

Genomic Location

Cytogenetic map

99C1-99C1

Sequence location

3R:29,804,290..29,807,127 [-]

Recombination map

3-99

Sequence

Get Decorated FASTA

Genomic Maps

GBrowse JBrowse

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Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

NCBI Genome Data Viewer

UCSC Genome Browser

Ensembl Genome Browser

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GO Summary Ribbons

[Detailed GO annotations]

Families, Domains and Molecular Function

Gene Group Membership (FlyBase)

KINESINS

Protein Family (UniProt, Sequence Similarities)

Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. NCD subfamily. (P20480)

Protein Domains/Motifs

InterPro

Kinesin motor domain; Kinesin motor domain, conserved site; P-loop containing nucleoside triphosphate hydrolase; Kinesin-like protein; Spindle pole body-associated protein Vik1/Cik1, microtubule binding domain; Kinesin motor domain superfamily

Molecular Function (see GO section for details)

Experimental Evidence

protein homodimerization activity

Predictions / Assertions

ATP binding; ATP-dependent microtubule motor activity, minus-end-directed; ATPase activity; microtubule binding; microtubule motor activity

Catalytic Activity (EC)

Experimental Evidence

Predictions / Assertions

ATP + H(2)O = ADP + phosphate (3.6.1.3)

ATP + H(2)O = ADP + phosphate (3.6.4.5)

Summaries

Gene Group Membership

KINESINS -: Kinesin superfamily proteins (KIFs) are microtubule motor proteins which use the hydrolysis of ATP to drive directional movement along microtubules. KIFs possess a well-conserved 360 residue globular head domain which binds and hydrolyses ATP and interacts with microtubules. Many KIFs homodimerize via coiled-coil interactions in the stalk region. KIFs bind cargo through their variable tail regions and are involved in transporting organelles, protein complexes, mRNAs and the movement of spindles and chromosomes during cell division. (Adapted from FBrf0219884).

UniProt Contributed Function Data

NCD is required for normal chromosomal segregation in meiosis, in females, and in early mitotic divisions of the embryo. The NCD motor activity is directed toward the microtubule's minus end.

(UniProt, P20480)

Phenotypic Description from the Red Book (Lindsley and Zimm 1992)

ncd: non-claret disjunctional

Disjunction in homozygous females abnormal; incidence of nondisjunction of all chromosome pairs in the first meiotic division and of meiotic and early-cleavage mitotic loss of maternally inherited chromosomes is high. X-chromosome recombination normal among both regular and exceptional progeny. Behavior of nonhomologues correlated; doubly disomic and doubly nullosomic ova more frequent than expected (Davis). Similar in action to ca of D. simulans (Sturtevant, 1929, Z. Wiss. Biol. Abt. A 135: 323-56). Two thirds of mitotic loss of chromosomes in progeny of ncd mothers takes place in the first zygotic division; one third takes place subsequently. The majority of X-chromosome loss (85-95%) is of the maternally inherited X but there is also appreciable loss of the paternally inherited X as well (Sequeira et al.). Somatic loss of X and 4 correlated (Portin, 1978, Heredity 41: 193-203). Cytological description of meiotic behavior in D. simulans ca females (Wald, 1936, Genetics 21: 264-81) includes abnormal first meiotic spindle, second meiotic arrest, and dispersal of chromosomes into multiple micronuclei; micronuclei also observed in ncd females (Roberts). Spindles frequently multipolar in first meiotic division (Puro) and in early-embryo nuclear divisions, and nuclei remain close together in center of egg (Kimble and Sandstedt, 1981, Genetics 978: s97). Kimble and Church (1981, J. Cell Sci. 62: 301-18) observed four classes of metaphase 1 configurations: (1) two or more spindles (2) abnormally wide spindles with widely separated bivalents (3) unipolar spindles, and (4) normal spindles; the first three comprise 80% of configurations. Approximately 20% of eggs of ncd1 females asymmetrical or with more than two appendages (Kimble and Church). Hinton and McEarchen (1963, DIS 37: 90) reported a haploid-diploid mosaic. ncd ovaries transplanted into normal host behave autonomously (Roberts, 1962, DIS 36: 120). Chromosome segregation normal in ncd males.

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the GBrowse view of Dmel\ncd or the JBrowse view of Dmel\ncd for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Comments on Gene Model

Gene model reviewed during 5.49

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.55

Sequence Ontology: Class of Gene

nuclear_gene

protein_coding_gene

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

ncd-RA

FBtr0085534

NM_057303

2340

700

ncd-RB

FBtr0344976

NM_001300663

2720

700

Additional Transcript Data and Comments

Reported size (kB)

2.3 (northern blot)

(Komma et al., 1991)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

RefSeq ID

GenBank

ncd-PA

FBpp0084900

77.5

700

9.65

NP_476651

AAF56942

ncd-PB

FBpp0311231

77.5

700

9.65

NP_001287592

AHN57591

Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

700 aa isoforms: ncd-PA, ncd-PB

Additional Polypeptide Data and Comments

Reported size (kDa)

44 (kD observed)

(Walker, 1995)

685 (aa)

(Stewart et al., 1993)

79 (kD)

(Hatsumi and Endow, 1992)

700 (aa)

(Komma et al., 1991, Endow et al., 1990)

685 (aa); 76 (kD predicted)

(McDonald and Goldstein, 1990)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

PDB - An information portal to biological macromolecular structures

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\ncd using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Linkouts

Gene Ontology (32 terms)

Molecular Function (6 terms)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

protein homodimerization activity

inferred from direct assay

(Tao et al., 2006)

Terms Based on Predictions or Assertions (5 terms)

CV Term

Evidence

References

ATP binding

inferred from electronic annotation with InterPro:IPR001752, InterPro:IPR019821

(assigned by InterPro )

(FlyBase Curators et al., 2004-)

ATP-dependent microtubule motor activity, minus-end-directed

non-traceable author statement

(Hirokawa et al., 1998)

ATPase activity

inferred from biological aspect of ancestor with PANTHER:PTN000648413

(assigned by GO_Central )

(Gaudet et al., 2011)

microtubule binding

inferred from biological aspect of ancestor with PANTHER:PTN000648413

(assigned by GO_Central )

(Gaudet et al., 2011)

microtubule motor activity

inferred from biological aspect of ancestor with PANTHER:PTN000648413

(assigned by GO_Central )

(Gaudet et al., 2011)

inferred from sequence or structural similarity

(Goldstein and Gunawardena, 2000)

Biological Process (16 terms)

Terms Based on Experimental Evidence (14 terms)

CV Term

Evidence

References

chromosome segregation

inferred from mutant phenotype

(Hallen et al., 2008)

distributive segregation

inferred from mutant phenotype

(Whyte et al., 1993)

inferred from genetic interaction with FLYBASE:Axs; FB:FBgn0000152

(Whyte et al., 1993)

meiotic spindle organization

inferred from mutant phenotype

(Komma and Endow, 1997)

microtubule bundle formation

inferred from direct assay

(Tao et al., 2006)

minus-end directed microtubule sliding

inferred from direct assay

(Tao et al., 2006)

mitotic centrosome separation

inferred from mutant phenotype

(Sharp et al., 1999)

inferred from genetic interaction with FLYBASE:Klp61F; FB:FBgn0004378

(Sharp et al., 1999)

mitotic spindle assembly

inferred from mutant phenotype

(Hallen et al., 2008)

mitotic spindle elongation

inferred from mutant phenotype

(Goshima et al., 2005)

mitotic spindle organization

inferred from mutant phenotype

(Goshima and Vale, 2005)

mRNA transport

inferred from mutant phenotype

(Fahmy et al., 2014)

inferred from genetic interaction with FLYBASE:αTub67C; FB:FBgn0087040

(Fahmy et al., 2014)

regulation of mitotic spindle assembly

inferred from genetic interaction with FLYBASE:SAK; FB:FBgn0026371

(Basto et al., 2008)

regulation of mitotic spindle elongation

inferred from mutant phenotype

(Hallen et al., 2008)

spindle assembly involved in meiosis

inferred from mutant phenotype

(Hallen et al., 2008)

spindle organization

inferred from mutant phenotype

(Morales-Mulia and Scholey, 2005)

Terms Based on Predictions or Assertions (3 terms)

CV Term

Evidence

References

microtubule-based movement

inferred from biological aspect of ancestor with PANTHER:PTN000648413

(assigned by GO_Central )

(Gaudet et al., 2011)

inferred from sequence or structural similarity

(Goldstein and Gunawardena, 2000)

mitotic spindle assembly

inferred from biological aspect of ancestor with PANTHER:PTN001537590

(assigned by GO_Central )

(Gaudet et al., 2011)

spindle assembly involved in female meiosis

non-traceable author statement

(Endow, 2003)

Cellular Component (10 terms)

Terms Based on Experimental Evidence (7 terms)

CV Term

Evidence

References

centrosome

inferred from direct assay

(Goshima and Vale, 2005)

colocalizes_with cortical microtubule cytoskeleton

inferred from direct assay

(Fahmy et al., 2014)

meiotic spindle

inferred from direct assay

(Zou et al., 2008)

mitotic spindle microtubule

inferred from direct assay

(Goshima and Vale, 2005)

nucleus

inferred from direct assay

(Goshima and Vale, 2005)

colocalizes_with perinuclear region of cytoplasm

inferred from direct assay

(Fahmy et al., 2014)

spindle

inferred from direct assay

(Komma and Endow, 1997)

Terms Based on Predictions or Assertions (4 terms)

CV Term

Evidence

References

kinesin complex

inferred from sequence or structural similarity

(Goldstein and Gunawardena, 2000)

inferred from biological aspect of ancestor with PANTHER:PTN000648413

(assigned by GO_Central )

(Gaudet et al., 2011)

microtubule

inferred from biological aspect of ancestor with PANTHER:PTN000648413

(assigned by GO_Central )

(Gaudet et al., 2011)

mitotic spindle

inferred from biological aspect of ancestor with PANTHER:PTN001537590

(assigned by GO_Central )

(Gaudet et al., 2011)

nucleus

inferred from biological aspect of ancestor with PANTHER:PTN001537590

(assigned by GO_Central )

(Gaudet et al., 2011)

Expression Data

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 1 -- 3

organism

Comment: maternally deposited

(Fisher et al., 2012)

embryonic stage 4 -- 6

organism | ubiquitous

(Fisher et al., 2012)

embryonic stage 7 -- 8

organism | ubiquitous

(Fisher et al., 2012)

embryonic stage 9 -- 10

antennal primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)

central brain primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)

visual primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)

dorsal head epidermis primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)

lateral head epidermis primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)

ventral head epidermis primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)

organism | ubiquitous

(Fisher et al., 2012)

ventral nerve cord primordium

(Fisher et al., 2012)

embryonic stage 11 -- 12

central brain primordium

(Fisher et al., 2012)

ventral nerve cord primordium

(Fisher et al., 2012)

embryonic stage 13 -- 16

embryonic brain

(Fisher et al., 2012)

embryonic central brain neuron

(Fisher et al., 2012)

embryonic central brain surface glia

(Fisher et al., 2012)

embryonic/larval nervous system

(Fisher et al., 2012)

lateral cord neuron

(Fisher et al., 2012)

ventral nerve cord

(Fisher et al., 2012)

Additional Descriptive Data

ncd transcripts are present in approximately wild type amounts in ncd^D females.

(Komma et al., 1991)

ncd transcripts are present in adult females and in gradually decreasing amounts during embryogenesis.

(Komma et al., 1991)

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

No Assay Recorded

Stage

Tissue/Position (including subcellular localization)

Reference

oogenesis

(Chandra et al., 1993)

Additional Descriptive Data

ncd protein is observed in early embryos in mitotic spindles and in polar bodies.

(Hatsumi and Endow, 1992)

ncd protein staining is observed in meiotic spindles.

(Hatsumi and Endow, 1992)

Marker for

Subcellular Localization

CV Term

Evidence

References

centrosome

inferred from direct assay

(Goshima and Vale, 2005)

colocalizes_with cortical microtubule cytoskeleton

inferred from direct assay

(Fahmy et al., 2014)

meiotic spindle

inferred from direct assay

(Zou et al., 2008)

mitotic spindle microtubule

inferred from direct assay

(Goshima and Vale, 2005)

nucleus

inferred from direct assay

(Goshima and Vale, 2005)

colocalizes_with perinuclear region of cytoplasm

inferred from direct assay

(Fahmy et al., 2014)

spindle

inferred from direct assay

(Komma and Endow, 1997)

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\ncd in GBrowse 2

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\ncd

View exonic expression by tissue for Dmel\ncd

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0002924

FLIGHT - Cell culture data for RNAi and other high-throughput technologies

FBgn0002924

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

CG7831-RA

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG7831

Flygut - An atlas of the Drosophila adult midgut

FBgn0002924

Images

FlyExpress - Embryonic expression images (BDGP data)

Show all FlyExpress processed images for Dmel\ncd

Stages(s) 1-3
Stages(s) 4-6
Stages(s) 9-10
Stages(s) 11-12
Stages(s) 13-16

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs and Phenotypes

Classical and Insertion Alleles ( 15 )

For All Classical and Insertion Alleles Show

Allele of ncd

Class

Mutagen

Associated Insertion

Stocks

Known lesion

ncd¹

loss of function allele

X ray

Yes

ncd^D

loss of function allele

ethyl methanesulfonate

Yes

ncd²

loss of function allele

ethyl methanesulfonate

Yes

ncd⁰⁵⁸⁸⁴

P-element activity

P{PZ}ncd⁰⁵⁸⁸⁴

Yes

ncd^EY03397

P-element activity

P{EPgy2}ncd^EY03397

Yes

ncd⁷

loss of function allele

spontaneous

Yes

ncd^GAL80ts-7

P-element activity

P{tubP-GAL80^ts}ncd^GAL80ts-7

Yes

ncd^5-HA-2411

P{RS5}ncd^5-HA-2411

Yes

ncd³

gamma ray

ncd⁴

gamma ray

ncd⁵

Yes

ncd⁶

Yes

ncd⁸

PM hybrid dysgenesis

Yes

ncd⁹

Yes

ncd^P39

loss of function allele

Delta2-3 transposase

P{lacW}ncd^P39

Yes

Other relevant insertions

Transgenic Constructs ( 23 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of ncd

Allele of ncd

Mutagen

Associated Transgenic Construct

Stocks

in vitro construct - coding region fusion

in vitro construct - coding region fusion

in vitro construct

P{ncd^+mEa}

ncd^+t5.3

in vitro construct - genomic fragment

P{ncd^+t5.3}

ncd^+t11.5

in vitro construct - genomic fragment

P{ncd-ca.11.5}

ncd^DN.54aa.GFP

P{ncdY485K-GFP}

ncd^{dsRNA.shRNA.UAS.V22}

ncd^HL.ncd.Venus

P{ncd-ncd.HL.YFP}

ncd^MC2

in vitro construct - deletion

in vitro construct - coding region fusion

P{ncdnk11-gfp*}

ncd^R6.9

in vitro construct - genomic fragment

P{ncd-ca.6.9}

ncd^{tCH322-118A01}

in vitro construct - genomic fragment

Transgenic constructs containing regulatory region of ncd

Deletions and Duplications ( 5 )

Disrupted in

Df(3R)ca^nd1

(Yamamoto et al., 1989)

Df(3R)ca^nd5

(Yamamoto et al., 1989)

Df(3R)ca^nd6

(Yamamoto et al., 1989)

Df(3R)ca^nd7

(Yamamoto et al., 1989)

Df(3R)ca^nd8

(Yamamoto et al., 1989)

Summary of Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

lethal | recessive

lethal - all die before end of embryonic stage

ncd¹

lethal - all die before end of embryonic stage | partially | recessive

ncd²

lethal - all die before end of embryonic stage | recessive

ncd¹

partially lethal | semidominant

ncd²

partially lethal - majority die | recessive

ncd⁰⁵⁸⁸⁴

viable

ncd^EY03397

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

ncd^GD12296

viable, with Scer\GAL4^Mef2.PR

ncd^GD12296

viable, with Scer\GAL4^pnr-MD237

ncd^GD12296

viable, with Scer\GAL4^tin.CΔ4

ncd^GD12296

Sterility

Allele

fertile

ncd^EY03397

Other Phenotypes

Allele

meiotic cell cycle defective

meiotic cell cycle defective, with ncd¹

meiotic cell cycle defective, with ncd^HL.ncd.Venus

ncd¹

meiotic cell cycle defective, with ncd^TL.ncd.Venus

ncd¹

meiotic cell cycle defective | embryonic stage

ncd^DN.54aa.GFP

meiotic cell cycle defective | female (with ncd¹)

ncd^D

meiotic cell cycle defective | female (with ncd^D)

ncd¹

meiotic cell cycle defective | mammalian oogenesis stage

ncd¹

meiotic cell cycle defective | recessive

mitotic cell cycle defective

mitotic cell cycle defective, with ncd¹

mitotic cell cycle defective, with ncd^HL.ncd.Venus

ncd¹

mitotic cell cycle defective, with ncd^TL.ncd.Venus

ncd¹

mitotic cell cycle defective | embryonic stage

ncd¹

mitotic cell cycle defective | larval stage

ncd¹

mitotic cell cycle defective | recessive

some die during embryonic stage

ncd¹

some die during embryonic stage | recessive

wild-type

Phenotype manifest in

Allele

aster | embryonic stage

ncd^DN.54aa.GFP

brain | larval stage

ncd¹

chromosome | oogenesis, with Scer\GAL4^{VP16.mat.αTub67C}

ncd^{dsRNA.shRNA.UAS.V22}

meiosis & nuclear chromosome

meiosis & nuclear chromosome & oocyte

meiosis & nuclear chromosome | female (with ncd¹)

ncd^D

meiosis & nuclear chromosome | female (with ncd^D)

ncd¹

meiosis II & spindle & egg

ncd¹

meiotic spindle | oogenesis, with Scer\GAL4^{VP16.mat.αTub67C}

ncd^{dsRNA.shRNA.UAS.V22}

mitosis & nuclear chromosome

mitotic anaphase & spindle

ncd¹

mitotic cell cycle

ncd¹

mitotic metaphase & spindle

ncd¹

oocyte | embryonic stage

ncd^DN.54aa.GFP

spindle

spindle & oocyte

spindle | embryonic stage

Orthologs

Downloads

Download All DIOPT Orthologs

Download All OrthoDB Orthologs

Human Orthologs (via DIOPT v7.1)

Homo sapiens (Human) (4)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Hsap\KIFC1

10 of 15

Yes

Hsap\KIFC3

3 of 15

Yes

Hsap\KIFC2

2 of 15

Yes

Hsap\KIF25

1 of 15

Yes

Model Organism Orthologs (via DIOPT v7.1)

Mus musculus (laboratory mouse) (4)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Mmus\Kifc5b

11 of 15

Yes

Mmus\Kifc1

7 of 15

Yes

Mmus\Kifc3

3 of 15

Yes

Mmus\Kifc2

1 of 15

Yes

Rattus norvegicus (Norway rat) (3)

Rnor\Kifc1

10 of 13

Yes

Rnor\Kifc3

2 of 13

Yes

Rnor\Kifc2

1 of 13

Yes

Xenopus tropicalis (Western clawed frog) (2)

Xtro\kifc1

8 of 12

Yes

Xtro\kifc3

2 of 12

Yes

Danio rerio (Zebrafish) (5)

Drer\kifc1

10 of 15

Yes

Drer\si:ch211-257p13.3

3 of 15

Yes

Drer\kifc3

2 of 15

Yes

Drer\kif25

1 of 15

Yes

Drer\si:dkey-96l17.6

1 of 15

Yes

Caenorhabditis elegans (Nematode, roundworm) (5)

Cele\klp-17

8 of 15

Yes

Cele\klp-15

5 of 15

Yes

Cele\klp-16

5 of 15

Yes

Cele\klp-3

3 of 15

Yes

Cele\C55B7.11

1 of 15

Yes

Arabidopsis thaliana (thale-cress) (18)

Atha\ATK1

7 of 9

Yes

Atha\ATK2

7 of 9

Yes

Atha\ATK3

7 of 9

Yes

Atha\ATK5

6 of 9

Yes

Atha\AT1G72250

3 of 9

Yes

Atha\AT2G22610

3 of 9

Yes

Atha\AT1G63640

2 of 9

Yes

Atha\AT1G73860

2 of 9

Yes

Atha\AT5G27550

2 of 9

Yes

Atha\AT1G09170

1 of 9

Yes

Atha\AT1G18410

1 of 9

Yes

Atha\AT1G55550

1 of 9

Yes

Atha\AT2G47500

1 of 9

Yes

Atha\AT3G10310

1 of 9

Yes

Atha\AT5G27950

1 of 9

Yes

Atha\AT5G41310

1 of 9

Yes

Atha\ATK4

1 of 9

Yes

Atha\KP1

1 of 9

Yes

Saccharomyces cerevisiae (Brewer's yeast) (1)

Scer\KAR3

9 of 15

Yes

Schizosaccharomyces pombe (Fission yeast) (2)

Spom\klp2

7 of 12

Yes

Spom\pkl1

7 of 12

Yes

Orthologs in Drosophila Species (via OrthoDB v9.1) ( EOG0919047N )

Organism

Common Name

Gene

AAA Syntenic Ortholog

Multiple Dmel Genes in this Orthologous Group

Drosophila melanogaster

fruit fly

Dmel\ncd

Drosophila suzukii

Spotted wing Drosophila

Drosophila simulans

Drosophila sechellia

Drosophila erecta

Drosophila yakuba

Drosophila ananassae

Drosophila pseudoobscura pseudoobscura

Dpse\GA20615

Drosophila persimilis

Dper\GL24007

Drosophila willistoni

Dwil\GK11161

Drosophila virilis

Dvir\GJ23134

Drosophila mojavensis

Dmoj\GI10718

Drosophila grimshawi

Dgri\GH20888

Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG091503OV )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Musca domestica

House fly

Mdoa\17012791

Glossina morsitans

Tsetse fly

Gmor\GMOY007841

Glossina morsitans

Tsetse fly

Gmor\GMOY004622

Lucilia cuprina

Australian sheep blowfly

Lcup\FF38_11858

Mayetiola destructor

Hessian fly

Mdes\Mdes002518

Aedes aegypti

Yellow fever mosquito

Aaeg\AAEL010803

Anopheles darlingi

American malaria mosquito

Adar\ADAC009704

Anopheles gambiae

Malaria mosquito

Agam\AGAP002248

Culex quinquefasciatus

Southern house mosquito

Cqui\CPIJ013519

Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W09HW )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Bombyx mori

Silkmoth

Bmor\BGIBMGA006545

Danaus plexippus

Monarch butterfly

Dple\DPOGS213806-PA

Heliconius melpomene

Postman butterfly

Hmel\HMEL014724

Heliconius melpomene

Postman butterfly

Hmel\HMEL008796

Heliconius melpomene

Postman butterfly

Hmel\HMEL014723

Apis florea

Little honeybee

Aflo\2314378436

Apis mellifera

Western honey bee

Amel\kinesin-14

Bombus impatiens

Common eastern bumble bee

Bimp\BIMP11265

Bombus impatiens

Common eastern bumble bee

Bimp\BIMP14615

Bombus terrestris

Buff-tailed bumblebee

Bter\15204655

Bombus terrestris

Buff-tailed bumblebee

Bter\15201571

Linepithema humile

Argentine ant

Lhum\LH16971

Megachile rotundata

Alfalfa leafcutting bee

Mrot\MROTU:00304d

Nasonia vitripennis

Parasitic wasp

Nvit\Nasvi2EG012225

Tribolium castaneum

Red flour beetle

Tcas\TC002539

Pediculus humanus

Human body louse

Phum\PHUM127680

Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X07XX )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Strigamia maritima

European centipede

Smar\SMAR012040

Ixodes scapularis

Black-legged tick

Isca\ISCW001730

Stegodyphus mimosarum

African social velvet spider

Smim\KFM82426.1

Daphnia pulex

Water flea

Dpux\DAPPUDRAFT_299597

Daphnia pulex

Water flea

Dpux\DAPPUDRAFT_237863

Daphnia pulex

Water flea

Dpux\DAPPUDRAFT_95626

Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G0DJX )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-KifC1

Ciona intestinalis

Vase tunicate

Cint\LOC100175368

Gallus gallus

Domestic chicken

Ggal\ENSGALG00000026798

Human Disease Model Data

FlyBase Human Disease Model Reports

Alleles Reported to Model Human Disease (Disease Ontology)

Download

Models ( 0 )

Allele

Disease

Evidence

References

Interactions ( 0 )

Allele

Disease

Interaction

References

Comments ( 0 )

Human Orthologs (via DIOPT v7.1)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

Complementation?

Transgene?

KIFC1; kinesin family member C1

10 of 15

603763

KIFC3; kinesin family member C3

3 of 15

604535

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

esyN Network Diagram

Interactions Browser

View in Interactions Browser

Please look at the Interaction Group reports for full details of the physical interactions

protein-protein

Interacting group

Assay

References

ncd

fluorescence technology, molecular sieving, molecular weight estimation by staining

(Fink et al., 2009)

ncd - 14-3-3ε

pull down, Identification by mass spectrometry, western blot, molecular weight estimation by staining

(Beaven et al., 2017)

ncd - Cenp-C

anti tag coimmunoprecipitation, peptide massfingerprinting

(Przewloka et al., 2011)

ncd - Eb1

fluorescent resonance energy transfer

(Szczęsna and Kasprzak, 2016)

ncd - Lkb1

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

ncd - Pdk1

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

ncd - Pi3K92E

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

ncd - Pten

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

ncd - S6kII

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

ncd - gig

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

ncd - sima

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

Summary of Genetic Interactions

esyN Network Diagram

esyN Network Key:

Suppression

Enhancement

View in Interactions Browser

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

ncd

suppressible

lwr

(Apionishev et al., 2001)

ncd

enhanceable

sub

(Giunta et al., 2002)

ncd

enhanceable

αTub67C

(Komma and Endow, 1997)

ncd

enhanceable

γTub37C

(Endow and Komma, 1998)

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Klp61F

enhanceable

ncd

(Wilson et al., 2004)

Klp61F

suppressible

ncd

(Radford et al., 2017, Wilson et al., 2004)

nod

enhanceable

ncd

(Knowles and Hawley, 1991)

SAK

enhanceable

ncd

(Basto et al., 2008)

sub

enhanceable

ncd

(Giunta et al., 2002)

sub

suppressible

ncd

(Cesario et al., 2006)

αTub67C

enhanceable

ncd

(Komma and Endow, 1997)

αTub67C

suppressible

ncd

(Gaspar and Szabad, 2009)

External Data

Linkouts

BioGRID - A database of protein and genetic interactions.

68381

DroID - A comprehensive database of gene and protein interactions.

FBgn0002924

InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.

43517

Pathways

Gene Group - Pathway Membership (FlyBase)

External Data

Linkouts

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

3-99

Cytogenetic map

99C1-99C1

Sequence location

3R:29,804,290..29,807,127 [-]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

99C1-99C1

Limits computationally determined from genome sequence between P{PZ}l(3)06743⁰⁶⁷⁴³ and P{PZ}ncd⁰⁵⁸⁸⁴

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

99C1-99C2

(determined by in situ hybridisation)

(Spradling et al., 1999)

99B-99B

(determined by in situ hybridisation)

(Sekelsky et al., 1999, Stewart et al., 1991)

99C1-99C2

(BDGP Project Members, 1994-1999)

99B-99C

(determined by in situ hybridisation)

(Endow and Hatsumi, 1991, McDonald and Goldstein, 1990)

99B8-99B10

(determined by in situ hybridisation)

(Yamamoto et al., 1989)

Experimentally Determined Recombination Data

Location

3-99

(FlyBase, 2016)

3-97.0

(Comeron et al., 2012)

3-100.7

(Komma et al., 1991)

Left of (cM)

(Komma et al., 1991)

Right of (cM)

(Komma et al., 1991)

Notes

Stocks and Reagents

Stocks (21)

Bloomington

2243

st¹ ncd^D

58144

y¹ v¹; P{TRiP.HMJ22094}attP40

19672

y¹ w^67c23; P{EPgy2}ncd^EY03397

58372

w¹¹¹⁸/Dp(1;Y)B^S; l(2)*^*/SM5; P{ncd-ncd.mRFP}F1F1

7018

w^*; sna^Sco/CyO; P{tubP-GAL80^ts}ncd^GAL80ts-7

11676

ry⁵⁰⁶ P{PZ}ncd⁰⁵⁸⁸⁴/TM3, ry^RK Sb¹ Ser¹

2245

Dp(1;Y)B^S; h¹ αTub67C³ st¹ ncd^D/TM3, Sb¹

Kyoto

106752

st¹ ncd^D

125618

w¹¹¹⁸; P{RS5}ncd^5-HA-2411

106753

Dp(1;Y)B^S; h¹ αTub67C³ st¹ ncd^D/TM3, Sb¹

VDRC

v22570

w¹¹¹⁸; P{GD12296}v22570

v22571

w¹¹¹⁸; P{GD12296}v22571/CyO

More stocks available...

Genomic Clones (17)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (68)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequences

BDGP DGC clones

LD29131

Other clones

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0002924

cDNA Clones, End Sequenced (ESTs)

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0002924

GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents

43517

Antibody Information

Laboratory Generated Antibodies

polyclonal

(Beaven et al., 2017, Hatsumi and Endow, 1992)

Commercially Available Antibodies

Other Information

Relationship to Other Genes

Source for database identify of

Source for database merge of

Source for merge of: ncd l(3)05884

(Spradling et al., 1999)

Additional comments

Most ncd mutations recovered simultaneously with ca mutations; the double mutants are designated "ca^nd" in the claret entry; they are caused by a single lesion affecting both transcription units and are inseparable.

Other Comments

RNAi screen using dsRNA made from templates generated with primers directed against this gene causes defects in spindle shape and unfocused spindle microtubules when assayed in S2 cells. This phenotype can be observed when the screen is performed with or without Cdc27 dsRNA.

(Goshima et al., 2007)

S2 cells transfected with dsRNA made from templates generated with primers directed against this gene show detachment of centrosomes from the spindle poles, resulting in a slight increase of spindle size.

(Goshima et al., 2005)

dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R⁺ cell morphology.

(Kiger et al., 2003)

Spindle pole movements in embryos are directed by a temporally coordinated balance of forces generated by three mitotic motors; cytoplasmic dynein, Klp61F and ncd. Dynein acts to move the poles apart throughout mitosis, and this activity is augmented by Klp61F after the fenestration of the nuclear envelope, which occurs at the onset of prometaphase. ncd generates forces that pull the poles together between interphase and metaphase, antagonising the activity of both cytoplasmic dynein and Klp61F and serving as a brake for spindle assembly.

(Sharp et al., 2000)

The ncd tail domain can promote microtubule assembly and stability.

(Karabay and Walker, 1999)

Mutants show disruption of chromosome segregation in meiosis whether or not they have undergone exchange and without any direct effect on the level of exchange.

(Sekelsky et al., 1999)

The inhibition of Klp61F function (via injected antibodies) embryos inhibits the formation of bipolar metaphase spindles.

(Sharp et al., 1999)

Analysis of Khc-ncd fusion proteins indicates that residues or regions contributing to motor polarity are present in the ncd neck region. The neck-motor junction is also critical for ncd minus-end movement.

(Endow and Waligora, 1998)

ncd is necessary for chromosome segregation and can interact specifically with the centromere. ncd requires only centromeric sequences for its action in chromosome segregation.

(Cook et al., 1997)

AMPPNP (a non-hydrolyzable ATP analog) is hydrolysed by the motor domain of ncd with a slow turnover. Turnover cannot be accelerated by microtubules.

(Suzuki et al., 1997)

Medium-resolution three-dimensional structure of microtubules interacting with two functional dimeric motors with opposite directionality (Khc and ncd) is determined.

(Arnal et al., 1996)

ncd microtubule motor performs an active role during mitosis in early embryos. The motor acts to maintain centrosome integrity and attachment to nuclei, contributes to midbody stability and helps to prevent chromosome loss during the early mitotic divisions.

(Endow and Komma, 1996)

ncd protein is required for normal spindle assembly kinetics and stabilisation of the spindle during metaphase arrest. Immunolocalisation analyses demonstrate that ncd is associated with spindle microtubules. Results suggest that microtubule binding by ncd promotes assembly of a stable bipolar spindle in the absence of typical microtubule organising centres (MTOCs).

(Matthies et al., 1996)

Missense mutation at residue 556, part of the motor domain, allows translocation on microtubules but at a reduced velocity relative to wild type. This provides evidence that the reduced rate of translocation is caused by altered binding of the mutant motor to microtubules.

(Moore et al., 1996)

The crystal structure of the MgADP complex of the ncd motor domain is determined to 2.5A by X ray crystallography and compared to the Khc motor domain. The domains are similar in structure and locations of conserved surface amino acids suggest the motors share a common microtubule-binding site. Structural and functional comparisons indicate the NTPases may have a similar strategy of changing conformation between NTP and NDP states.

(Sablin et al., 1996)

ncd and Khc differ in their initial, weak binding to microtubules which causes the proteins to move in opposite directions. The nature of a structural bias that may serve as a determinant of motor polarity is not clear, results suggest the microtubule binding site may determine direction.

(Song and Endow, 1996)

Neutron scattering study reveals the overall shape of the motor domain is not the major determinant of the directionality of the movement along microtubules.

(Eden et al., 1995, Fujiwara et al., 1995)

Three dimensional reconstruction of the monomeric motor domain at the carboxy terminus of ncd is presented (FBrf0083611).

(Hackney, 1995)

A three dimensional map of tubulin sheets decorated with monomeric recombinant ncd motor domains has been calculated by negative-stain electron microscopy and image analysis. Comparisons with a control structure of tubulin alone reveals that each motor domain binds to the crest of a single protofilament making extensive contacts with both the α and β tubulin monomers, binding of the motor domain results in significant conformational change in both the tubulin monomers.

(Hoenger et al., 1995)

ADP release is the rate-limiting step for ATP turnover for ncd protein.

(Lockhart et al., 1995)

The motile and enzymatic properties of the ncd protein have been analysed.

(Shimizu et al., 1995)

Mixtures of ncd motor domain and full length ncd protein treated with the zero-length cross linker EDC generates covalently cross linked products of ncd with βTub56D and ncd with αTub84B. These results indicate that the ncd motor domain interacts with both βTub56D and αTub84B.

(Walker, 1995)

Identified as a 90kD polypeptide in an ATP MAPs 1-24 hour embryonic fraction.

(Cole et al., 1994)

The sequence of the ncd protein has been compared with the sequences of a variety of kinesin family proteins.

(Goodson et al., 1994)

Despite ncds reversed directionality relative to kinesin, ncd has very similar ATPase kinetics to kinesin and an identical mode of coupling to microtubule binding.

(Lockhart and Cross, 1994)

Encoded protein consists of 3 domains: a basic, proline-rich N terminal tail, a central α-helical coiled coil stalk, and a C terminal motor. Expression of different regions of ncd in bacteria indicates that ncd consists of three domains, a basic, proline rich N-terminal tail, a central alpha-helical coiled coil stalk and a C-terminal motor domain. N terminus proteins bundle microtubules in motility assays and show ATP-independent binding to microtubule in solution. C terminus proteins retain the ability to hydrolyse ATP in solution and the stalk region is important for dimerisation.

(Chandra et al., 1993)

N-terminal truncation of the 'tail' region of the protein identifies a weak binding state of the ncd motor. This weak binding state may be important in the mechanochemical function of the ncd motor protein.

(Chandra et al., 1993)

A series of truncated kinesin heavy chain and ncd proteins were generated and assayed for movement along microtubules in vitro: conserved domain of both proteins has microtubule motor activity, and direction of movement is intrinsic to conserved motor domain.

(Stewart et al., 1993)

Mutations at ncd disrupt meiotic spindle formation.

(Whyte et al., 1993)

ncd protein localizes to both the mitotic and meiotic spindle.

(Hatsumi and Endow, 1992)

ncd has been cloned and characterised.

(McDonald and Goldstein, 1990)

The behaviour of the ncd protein has been studied in vitro, showing that ncd is a minus end-directed microtubule motor.

(McDonald et al., 1990)

ncd is a minus-end directed microtubule motor. It also generates torque, causing microtubules to rotate as they move forward in in vitro motility assays.

(Walker et al., 1990)

The 'ca^nd' locus has been found to be two closely linked but separate genes, ca and ncd.

(Yamamoto et al., 1989)

Disjunction in homozygous females abnormal; incidence of nondisjunction of all chromosome pairs in the first meiotic division and of meiotic and early-cleavage mitotic loss of maternally inherited chromosomes is high. X-chromosome recombination normal among both regular and exceptional progeny. Behavior of nonhomologues correlated; doubly disomic and doubly nullosomic ova more frequent than expected (Davis, 1969). Similar in action to ca of D.simulans (Sturtevant, 1929). Two thirds of mitotic loss of chromosomes in progeny of ncd mothers takes place in the first zygotic division; one third takes place subsequently. The majority of X-chromosome loss (85-95%) is of the maternally inherited X but there is also appreciable loss of the paternally inherited X as well (Sequeira et al., 1989). Somatic loss of X and 4 correlated (Portin, 1978). Cytological description of meiotic behavior in D.simulans ca females (Wald, 1936) includes abnormal first meiotic spindle, second meiotic arrest, and dispersal of chromosomes into multiple micronuclei; micronuclei also observed in ncd females (Roberts, 1962). Spindles frequently multipolar in first meiotic division (Puro) and in early-embryo nuclear divisions and nuclei remain close together in center of egg (Kimble and Sandstedt, 1981). Kimble and Church (1981) observed four classes of metaphase 1 configurations: (1) two or more spindles (2) abnormally wide spindles with widely separated bivalents (3) unipolar spindles and (4) normal spindles; the first three comprise 80% of configurations. Approximately 20% of eggs of ncd¹ females asymmetrical or with more than two appendages (Kimble and Church, 1981). Hinton and McEarchen (1963) reported a haploid-diploid mosaic. ncd ovaries transplanted into normal host behave autonomously (Roberts, 1962). Chromosome segregation normal in ncd males.

Origin and Etymology

Discoverer

Etymology

Identification

External Crossreferences and Linkouts ( 52 )

Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

43517

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information

P20480

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Other crossreferences

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0002924

InterPro - A database of protein families, domains and functional sites

PDB - An information portal to biological macromolecular structures

Linkouts

BioGRID - A database of protein and genetic interactions.

68381

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center cDNA clones

FBgn0002924

DroID - A comprehensive database of gene and protein interactions.

FBgn0002924

DRSC - Results frm RNAi screens

FBgn0002924

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

FLIGHT - Cell culture data for RNAi and other high-throughput technologies

FBgn0002924

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

CG7831-RA

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG7831

Flygut - An atlas of the Drosophila adult midgut

FBgn0002924

FlyMine - An integrated database for Drosophila genomics

FBgn0002924

GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents

43517

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

TC002539

Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution

Interactive Fly

InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.

43517

KEGG Genes - Molecular building blocks of life in the genomic space.

Dmel_CG7831

modMine - A data warehouse for the modENCODE project

FBgn0002924

Synonyms and Secondary IDs (24)

Reported As

Symbol Synonym

CG7831

(Kolkhof et al., 2017, Çiçek et al., 2016, Moutinho-Pereira et al., 2013, Salemi et al., 2013, Chen et al., 2012, Müller et al., 2010, Ni et al., 2010.12.1, Zhang et al., 2010, Keleman et al., 2009.8.5, Maresca and Salmon, 2009, Goshima et al., 2007, Asha et al., 2003, Goldstein and Gunawardena, 2000)

DmNCD

(Matthies et al., 2001, Hirokawa et al., 1998)

DmNcd

(Hirokawa, 2012, Simeonov et al., 2009, Dagenbach and Endow, 2004, Wang et al., 2002, Moore and Endow, 1996)

KIF C1

(Miki et al., 2001)

KIFC1

(Hirokawa, 2012.11.20)

NCD

(Lawrence et al., 2002)

Ncd

(Beaven et al., 2017, Molodtsov et al., 2016, Szczęsna and Kasprzak, 2016, Zhang et al., 2015, Braun et al., 2013, Moutinho-Pereira et al., 2013, Salemi et al., 2013, Hirokawa, 2012.11.20, Liu et al., 2012, Szczęsna and Kasprzak, 2012, Braun et al., 2011, Cochran et al., 2011, Przewloka et al., 2011, Civelekoglu-Scholey et al., 2010, Heuston et al., 2010, Hjelm et al., 2010, Tao and Scholey, 2010, Ally et al., 2009, Brust-Mascher et al., 2009, Ding et al., 2009, Fink et al., 2009, Kocik et al., 2009, Maresca and Salmon, 2009, Moutinho-Pereira et al., 2009, Venken et al., 2009, Cheerambathur et al., 2008, Furuta and Toyoshima, 2008, Hallen et al., 2008, Kwon et al., 2008, Rogers et al., 2008, Shaklee et al., 2008, Trammell et al., 2008, Goshima et al., 2007, Goshima et al., 2007, Oladipo et al., 2007, Tao et al., 2006, Cytrynbaum et al., 2005, Goshima and Vale, 2005, Goshima et al., 2005, Miki et al., 2005, Morales-Mulia and Scholey, 2005, Skold et al., 2005, Wilson et al., 2005, Kwon et al., 2004, Goshima and Vale, 2003, Miki et al., 2001, Goodson et al., 1994)

(Walker et al., 1990)

ca^nd

(Brust-Mascher et al., 2009)

(Pokrywka et al., 2014)

l(3)05884

(Meister and Braun, 1995.10, BDGP Project Members, 1994-1999, Berkeley Drosophila Genome Project, 1993.6.1)

ncd

(Hughes et al., 2018, Radford et al., 2017, Bougé and Parmentier, 2016, Das et al., 2016, Baumbach et al., 2015, Fahmy et al., 2014, Gupta et al., 2014, Liang et al., 2014, Colombié et al., 2013, Kwon et al., 2013, Japanese National Institute of Genetics, 2012.5.21, Korenjak et al., 2012, Endow and Hallen, 2011, Friedman et al., 2011, Naber et al., 2011, Reis et al., 2011, Butterfield et al., 2010, Mattie et al., 2010, Müller et al., 2010, Wendler et al., 2010, Anderson et al., 2009, Gaspar and Szabad, 2009, Hallen and Endow, 2009, Basto et al., 2008, Cesario and McKim, 2008, Hallen et al., 2008, Somma et al., 2008, Zou et al., 2008, Georlette et al., 2007, Makino et al., 2007, Page et al., 2007, Cesario et al., 2006, Ferree and Sullivan, 2006, Ito et al., 2006, Mukai et al., 2006, Cullen et al., 2005, Jang et al., 2005, Sciambi et al., 2005, Skold et al., 2005, Apionishev et al., 2001, Whyte et al., 1993)

ndc

(Asha et al., 2003)

Name Synonyms

Claret nondisjunctional

(Brust-Mascher et al., 2009)

Kinesin-14

(Szczęsna and Kasprzak, 2016, Braun et al., 2011, Sciambi et al., 2005)

Kinesin3A

(Kollmar, 2015.9.15)

Non-Claret Disjunctional

(Hirokawa, 2012.11.20)

Nonclaret disjunctional

(Skold et al., 2005)

kinesin-14

(Molodtsov et al., 2016, Salemi et al., 2013, Liu et al., 2012, Cochran et al., 2011, Butterfield et al., 2010, Civelekoglu-Scholey et al., 2010, Tao and Scholey, 2010, Fink et al., 2009)

non-claret disjunction

(Page et al., 2007)

non-claret disjunctional

(Das et al., 2016, Mukai et al., 2006)

non-claret-disjunctional

(Gaspar and Szabad, 2009)

nonclaret disjunction

(Maresca and Salmon, 2009)

nonclaret disjunctional

(Fahmy et al., 2014, Naber et al., 2011, Hallen et al., 2008, Zou et al., 2008, Ito et al., 2006)

Secondary FlyBase IDs

FBgn0010880

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

References (362)

The following external sites may use different assemblies or annotations than FlyBase.

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