FB2019_05, released Oct 15, 2019

Gene: Dmel\ndl

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General Information
Symbol
Dmel\ndl
Species
D. melanogaster
Name
nudel
Annotation Symbol
CG10129
Feature Type
protein_coding_gene
FlyBase ID
FBgn0002926
Gene Model Status
Current
Stock Availability
8 publicly available
Gene Snapshot
nudel (ndl) encodes a multi-functional protein with serine protease activity. It is required for both eggshell biogenesis and embryonic dorsoventral patterning. [Date last reviewed: 2019-03-14]
Other Summaries
Also Known As
SP89
Key Links
Genomic Location
Cytogenetic map
65B5-65B5
Sequence location
3L:6,593,938..6,603,366 [-]
Recombination map
3-17
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
GO Summary Ribbons
Gene Group (FlyBase)
Pathway (FlyBase)
Protein Family (UniProt)
Belongs to the peptidase S1 family. (P98159)
Protein Signatures (InterPro)
Molecular Function (GO)
[Detailed GO annotations]
Experimental Evidence
serine-type endopeptidase activity
Predictions / Assertions
serine-type endopeptidase activity
Summaries
Gene Group (FlyBase)
DORSAL GROUP -
The Dorsal group genes encode components of the Toll pathway and were initially identified by maternal effect mutations resulting in the dorsalization of the embryo. (Adapted from FBrf0091014 and FBrf0223077).
S1A SERINE PROTEASES - TRYPSIN-LIKE -
Trypsin-like serine proteases of the S1A family are endopeptidases that cleave amide substrates following Arginine or Lysine at the P1 position. (Adapted from FBrf0239469).
Pathway (FlyBase)
Extracellular Spatzle Activating Pathway Core Components -
In Drosophila, activation of the Toll pathway is controlled by the generation of a cleaved, active, Toll-binding form of spatzle ligand. Proteolytic activation of spatzle ligand lies downstream of several zymogen activation cascades that are initiated by different cues. In dorsal-ventral patterning, localized activation of spz results in ventral nuclear accumulation of dl. During viral and fungal and gram positive bacterial immune challenge, zymogen cascades are activated by extracellular pattern recognition receptors or virulence factor-mediated cleavage of the zymogen persephone (psh). (Adapted from FBrf0091014 and FBrf0223077).
Protein Function (UniProtKB)
Component of the extracellular signaling pathway that establishes the dorsal-ventral pathway of the embryo. Three proteases; ndl, gd and snk process easter to create active easter. Active easter defines cell identities along the dorsal-ventral continuum by activating the spz ligand for the Tl receptor in the ventral region of the embryo. Nudel, pipe and windbeutel together trigger the protease cascade within the extraembryonic perivitelline compartment which induces dorsoventral polarity of the Drosophila embryo.
(UniProt, P98159)
Phenotypic Description (Red Book; Lindsley and Zimm 1992)
ndl: nudel
Maternal effect mutation producing totally dorsalized embryos. Spacing of transverse stripes of ftz protein altered in mutant embryos (Carroll, Winslow, Twombly, and Scott, 1987, Development 99: 327-32).
Summary (Interactive Fly)
serine protease - docking protein - dorsal group - part of a signaling cascade that determines dorsal/ventral polarity of the embryo - required for eggshell biogenesis
Gene Model and Products
Number of Transcripts
1
Number of Unique Polypeptides
1

Please see the GBrowse view of Dmel\ndl or the JBrowse view of Dmel\ndl for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model
Gene model reviewed during 5.46
Sequence Ontology: Class of Gene
nuclear_gene
protein_coding_gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
ndl-RA
FBtr0076984
NM_079223
8230
2616
Additional Transcript Data and Comments
Reported size (kB)
8.4 (northern blot)
(Hong and Hashimoto, 1995)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
ndl-PA
FBpp0076693
292.5
2616
5.77
NP_523947
AAF50656
Polypeptides with Identical Sequences

There is only one protein coding transcript and one polypeptide associated with this gene

Additional Polypeptide Data and Comments
Reported size (kDa)
2616 (aa); 292 (kD predicted)
(Hong and Hashimoto, 1995)
Comments
External Data
Post Translational Modification
Requires cleavage for activation (presumably).
(UniProt, P98159)
Crossreferences
InterPro - A database of protein families, domains and functional sites
MEROPS - An information resource for peptidases (also termed proteases, proteinases and proteolytic enzymes) and the proteins that inhibit them.
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\ndl using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Gene Ontology (12 terms)
Molecular Function (1 term)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
serine-type endopeptidase activity
inferred from mutant phenotype
(Mineo et al., 2017, LeMosy et al., 1998)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
serine-type endopeptidase activity
inferred from sequence model
(Cao and Jiang, 2018, Ross et al., 2003)
Biological Process (9 terms)
Terms Based on Experimental Evidence (7 terms)
CV Term
Evidence
References
dorsal/ventral axis specification
inferred from mutant phenotype
(Mineo et al., 2017, LeMosy et al., 1998, Hong and Hashimoto, 1996, Hong and Hashimoto, 1995, Stein et al., 1991)
inferred from genetic interaction with FLYBASE:ea; FB:FBgn0000533
(Chasan et al., 1992)
egg activation
inferred from mutant phenotype
(Tadros et al., 2003)
eggshell chorion assembly
inferred from mutant phenotype
(Hong and Hashimoto, 1996)
positive regulation of Toll signaling pathway
inferred from mutant phenotype
(LeMosy et al., 1998, Misra et al., 1998)
inferred from direct assay
(LeMosy et al., 2001)
protein autoprocessing
inferred from mutant phenotype
(LeMosy et al., 1998)
protein processing
inferred from mutant phenotype
(Mineo et al., 2017)
zymogen activation
inferred from mutant phenotype
(Steen et al., 2010, LeMosy et al., 2001, LeMosy et al., 1998)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
maternal specification of dorsal/ventral axis, oocyte, soma encoded
inferred from electronic annotation with InterPro:IPR034381
(assigned by InterPro )
(FlyBase Curators et al., 2004-)
proteolysis
inferred from sequence model
(Ross et al., 2003)
Cellular Component (2 terms)
Terms Based on Experimental Evidence (2 terms)
CV Term
Evidence
References
extracellular region
inferred from direct assay
(Mineo et al., 2017)
perivitelline space
inferred from direct assay
(LeMosy et al., 1998)
Terms Based on Predictions or Assertions (0 terms)
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
oogenesis stage S7 -- S10
follicle cell
(Hong and Hashimoto, 1995)
northern blot
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage | female
ovary
(Hong and Hashimoto, 1995)
Additional Descriptive Data
ndl transcripts are expressed almost exclusively in follicle cells. They are first detected at stage S7 of oogenesis but reach a peak at stages S9 and S10. In the majority of egg chambers, the transcript is asymmetrically distributed with a higher level seen in ventral than in dorsal follicle cells. The transcript decreases in abundance dramatically in late stage S10 and is undetectable by stage S11.
(Hong and Hashimoto, 1995)
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Proteolytically processed segments of ndl protein are secreted into the perivitelline space and stably localized.
(Stein et al., 2008)
Marker for
 
Subcellular Localization
CV Term
Evidence
References
extracellular region
inferred from direct assay
(Mineo et al., 2017)
perivitelline space
inferred from direct assay
(LeMosy et al., 1998)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\ndl in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
Flygut - An atlas of the Drosophila adult midgut
Images
FlyBase Wiki
Image Based Resources
Alleles, Insertions, and Transgenic Constructs
Classical and Insertion Alleles ( 23 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 9 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of ndl
Transgenic constructs containing regulatory region of ndl
Deletions and Duplications ( 3 )
Phenotypes
Orthologs
Downloads
Download All DIOPT Orthologs
Download All OrthoDB Orthologs
Human Orthologs (via DIOPT v7.1)
Homo sapiens (Human) (0)
No records found.
Model Organism Orthologs (via DIOPT v7.1)
Mus musculus (laboratory mouse) (0)
No records found.
Rattus norvegicus (Norway rat) (0)
No records found.
Xenopus tropicalis (Western clawed frog) (0)
No records found.
Danio rerio (Zebrafish) (0)
No records found.
Caenorhabditis elegans (Nematode, roundworm) (0)
No records found.
Arabidopsis thaliana (thale-cress) (0)
No records found.
Saccharomyces cerevisiae (Brewer's yeast) (0)
No records found.
Schizosaccharomyces pombe (Fission yeast) (0)
No records found.
Orthologs in Drosophila Species (via OrthoDB v9.1) ( EOG0919005B )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila melanogaster
fruit fly
Dmel\ndl
Drosophila suzukii
Spotted wing Drosophila
Dsuz\DS10_00004200
Drosophila simulans
Dsim\GD13121
Drosophila sechellia
Dsec\GM13834
Drosophila erecta
Dere\GG14054
Drosophila yakuba
Dyak\GE20478
Drosophila ananassae
Dana\GF10896
Drosophila pseudoobscura pseudoobscura
Dpse\GA10095
Drosophila willistoni
Dwil\GK12588
Drosophila virilis
Dvir\GJ11983
Drosophila mojavensis
Dmoj\GI13207
Drosophila grimshawi
Dgri\GH16271
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG0915003C )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Mdoa\17007822
Glossina morsitans
Tsetse fly
Gmor\GMOY007795
Lucilia cuprina
Australian sheep blowfly
Lcup\FF38_11201
Mayetiola destructor
Hessian fly
Mdes\Mdes002448
Mayetiola destructor
Hessian fly
Mdes\Mdes002449
Aedes aegypti
Yellow fever mosquito
Aaeg\AAEL016971
Anopheles darlingi
American malaria mosquito
Adar\ADAC002420
Anopheles gambiae
Malaria mosquito
Agam\AGAP007280
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ002112
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W02G4 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Bombyx mori
Silkmoth
Bmor\BGIBMGA014089
Danaus plexippus
Monarch butterfly
Dple\DPOGS208138-PA
Heliconius melpomene
Postman butterfly
Hmel\HMEL016514
Apis florea
Little honeybee
Aflo\2561786676
Apis mellifera
Western honey bee
Amel\GB40567
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP11541
Bombus terrestris
Buff-tailed bumblebee
Bter\15207134
Linepithema humile
Argentine ant
Lhum\LH20772
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:001446
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG005462
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG023071
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_02794
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_02791
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_02793
Tribolium castaneum
Red flour beetle
Tcas\P19
Pediculus humanus
Human body louse
Phum\PHUM269170
Rhodnius prolixus
Kissing bug
Rpro\RPRC000049
Cimex lectularius
Bed bug
Clec\CLEC007702
Cimex lectularius
Bed bug
Clec\CLEC004686
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI009492
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI083514
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_02313
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X02DP )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Stegodyphus mimosarum
African social velvet spider
Smim\KFM59828.1
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_317027
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G0DF7 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Srcr146
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Polsrs
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Srcr224
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Sr/Lrr/Gpcr
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Srcr22
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Srcr197
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Srcr149
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Srcr13
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Klkb1
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Srcr96
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Srcr120
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Srcr167
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Srcr53
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Ly/Cub/Sr/Zp
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Srcr196
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Ela2L
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Srcr1
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Srcr215
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Tmprss9L
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Srcr59
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Srcr64
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Hypp_1191
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Srcr105
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Srcr218
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Srcr170
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Srcr227
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Srcr85
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-GramarL3
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Srcr66
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Srcr136
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Srcr25
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Srcr61
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Srcr71
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Dmbt1L_5
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Srcr82
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Srcr8
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Srcr52
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Srcr222
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Srcr40
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Prss12L
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Srcr23
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Srcr77
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Srcr127
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Srcr134
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Srcr10
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Srcr223
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Srcr63
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Sr/Gpcr
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Srcr83
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Srcr32
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Srcr101
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Srcr100
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Tmprss6
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Srcr12_1
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Srcr113
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Dmbt1L_10
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Srcr107
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Srcr219
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Srcr189
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Srcr57
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Srcr4
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Srcr122
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Srcr154
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Srcr188
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Srcr104
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-NotchL_2
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Tmps9
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Srcr192
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Srcr81
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-St14L_4
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Srcr5
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Srcr28
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-KlkB
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Srcr220
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Srcr69
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Srcr60
Strongylocentrotus purpuratus
Purple sea urchin
Spur\SPU_015154gn
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Lrp4_6
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Srcr176
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Srcr194
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Srcr15
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Sr/Egf/Lnb/7Tm/Gpcr
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-St14L_29
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Srcr79
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Srcr161
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Srcr91
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Sr/Lrr/Gpcr_2
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Srcr123
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-trypsinL_2
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Srcr172
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Srcr166
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Sr/Lrr/Gpcr_3
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Srcr137
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Tmprss9
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Srcr213
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Egfia_5
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-trypsinL_1
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Srcr163
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Dmbt1L
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Sorl1L
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Srcr14
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Lrp2L
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Srcr179
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Srcr92
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Hypp_143
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Srcr206
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Tmprss3
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Srcr18
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Dmbt1L_3
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Srcr50
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Srcr165
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Srcr42
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Srcr75
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Egfiii
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Masp
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Srcr204
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Srcr48
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Srcr94
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Srcr228
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Srcr193
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Cubn-5
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Hypp_2211
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Srcr34
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Srcr97
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Srcr37
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Srcr214
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Srcr112
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Srcr80
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Tll2L_1
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Srcr46
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Hypp_73
Strongylocentrotus purpuratus
Purple sea urchin
Spur\SPU_026637gn
Strongylocentrotus purpuratus
Purple sea urchin
Spur\SPU_000926gn
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Srcr216
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Prss7_1
Strongylocentrotus purpuratus
Purple sea urchin
Spur\SPU_001110gn
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Srcr174
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Srcr143
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Srcr187
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Tmprss9L_1
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Srcr226
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Srcr159
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Srcr43
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Srcr76
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Srcr173
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Srcr11
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Srcr47
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Srcr152
Strongylocentrotus purpuratus
Purple sea urchin
Spur\SPU_018949gn
Strongylocentrotus purpuratus
Purple sea urchin
Spur\SPU_026926gn
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Srcr114
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Srcr160
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Srcr198
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Srcr86
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Srcr221
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Srcr180
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Srcr103
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-St14L_2
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-GramarL2
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-trypsinL
Strongylocentrotus purpuratus
Purple sea urchin
Spur\SPU_010210gn
Strongylocentrotus purpuratus
Purple sea urchin
Spur\SPU_003549gn
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Srcr119
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Srcr125
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Srcr108
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Srcr147
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Dmbt1L_6
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Srcr207
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Srcr70
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Clect_113
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-GramarL1
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Srcr9
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Srcr110
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Srcr155
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Klkb1L1
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Srcr2
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Srcr44
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Srcr51
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Srcr116
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Srcr157
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Cgsp1
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Tmprss9_2
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Srcr72
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Srcr106
Strongylocentrotus purpuratus
Purple sea urchin
Spur\SPU_005658gn
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-St14L
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Srcr175
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Tmprss2L_2
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Srcr142
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Srcr118
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Srcr162
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-trypsinL_3
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Srcr56
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Srcr58
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Srcr225
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Srcr121
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Hypp_119
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Srcr24
Strongylocentrotus purpuratus
Purple sea urchin
Spur\SPU_003041gn
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Hypp_242
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Srcr153
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Srcr65
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Srcr210
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Srcr84
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Sea/Ldla/Cub
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-EgfiiiL
Strongylocentrotus purpuratus
Purple sea urchin
Spur\SPU_020206gn
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Srcr164
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Srcr144
Strongylocentrotus purpuratus
Purple sea urchin
Spur\SPU_005560gn
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Dmbt1L_4
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Srcr186
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Srcr6
Strongylocentrotus purpuratus
Purple sea urchin
Spur\SPU_022975gn
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Srcr29
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Prss7L
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Srcr41
Strongylocentrotus purpuratus
Purple sea urchin
Spur\SPU_019928gn
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Srcr78
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Srcr129
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Hypp_373
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Srcr30
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Srcr26
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Srcr67
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Srcr93
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Srcr68
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Srcr208
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Tmprss5L
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Srcr168
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Srcr191
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Srcr169
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Tmprss2L
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Srcr95
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Srcr141
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-St14L_3
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Srcr145
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-SerpineL
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Tmprss3_1
Ciona intestinalis
Vase tunicate
Cint\LOC100175526
Ciona intestinalis
Vase tunicate
Cint\LOC100183060
Ciona intestinalis
Vase tunicate
Cint\LOC100187393
Ciona intestinalis
Vase tunicate
Cint\ENSCING00000018117
Ciona intestinalis
Vase tunicate
Cint\LOC100177359
Ciona intestinalis
Vase tunicate
Cint\LOC100178581
Ciona intestinalis
Vase tunicate
Cint\LOC101242191
Ciona intestinalis
Vase tunicate
Cint\LOC100177776
Ciona intestinalis
Vase tunicate
Cint\ENSCING00000016095
Ciona intestinalis
Vase tunicate
Cint\ENSCING00000018648
Ciona intestinalis
Vase tunicate
Cint\LOC100179458
Ciona intestinalis
Vase tunicate
Cint\LOC100175462
Ciona intestinalis
Vase tunicate
Cint\ENSCING00000007782
Ciona intestinalis
Vase tunicate
Cint\ENSCING00000020354
Ciona intestinalis
Vase tunicate
Cint\ENSCING00000020838
Ciona intestinalis
Vase tunicate
Cint\ENSCING00000023443
Ciona intestinalis
Vase tunicate
Cint\LOC100182594
Ciona intestinalis
Vase tunicate
Cint\LOC100182053
Ciona intestinalis
Vase tunicate
Cint\ENSCING00000013897
Ciona intestinalis
Vase tunicate
Cint\LOC100182205
Ciona intestinalis
Vase tunicate
Cint\LOC100183738
Ciona intestinalis
Vase tunicate
Cint\ENSCING00000003449
Ciona intestinalis
Vase tunicate
Cint\ENSCING00000007451
Ciona intestinalis
Vase tunicate
Cint\ENSCING00000023472
Ciona intestinalis
Vase tunicate
Cint\LOC100185223
Ciona intestinalis
Vase tunicate
Cint\LOC100185892
Ciona intestinalis
Vase tunicate
Cint\ENSCING00000009644
Ciona intestinalis
Vase tunicate
Cint\ENSCING00000009888
Ciona intestinalis
Vase tunicate
Cint\LOC100187379
Ciona intestinalis
Vase tunicate
Cint\ENSCING00000006812
Ciona intestinalis
Vase tunicate
Cint\ENSCING00000016299
Ciona intestinalis
Vase tunicate
Cint\LOC100179089
Gallus gallus
Domestic chicken
Ggal\ENSGALG00000009588
Gallus gallus
Domestic chicken
Ggal\PRSS7
Gallus gallus
Domestic chicken
Ggal\TMPRSS6
Gallus gallus
Domestic chicken
Ggal\ENSGALG00000014720
Gallus gallus
Domestic chicken
Ggal\ENSGALG00000028071
Gallus gallus
Domestic chicken
Ggal\TMPRSS7
Gallus gallus
Domestic chicken
Ggal\ENSGALG00000025752
Gallus gallus
Domestic chicken
Ggal\LOC423740
Gallus gallus
Domestic chicken
Ggal\TMPRSS3
Gallus gallus
Domestic chicken
Ggal\LOC423942
Gallus gallus
Domestic chicken
Ggal\LOC418421
Gallus gallus
Domestic chicken
Ggal\ENSGALG00000004866
Gallus gallus
Domestic chicken
Ggal\LOC768817
Gallus gallus
Domestic chicken
Ggal\ENSGALG00000026051
Gallus gallus
Domestic chicken
Ggal\ENSGALG00000009103
Gallus gallus
Domestic chicken
Ggal\ST14
Gallus gallus
Domestic chicken
Ggal\TMPRSS2
Gallus gallus
Domestic chicken
Ggal\ENSGALG00000001917
Gallus gallus
Domestic chicken
Ggal\ENSGALG00000027189
Gallus gallus
Domestic chicken
Ggal\OVCH2
Gallus gallus
Domestic chicken
Ggal\ENSGALG00000002213
Gallus gallus
Domestic chicken
Ggal\TMPRSS11F
Gallus gallus
Domestic chicken
Ggal\CELA2A
Gallus gallus
Domestic chicken
Ggal\PRSS3
Gallus gallus
Domestic chicken
Ggal\PRSS2
Gallus gallus
Domestic chicken
Ggal\PRSS12
Gallus gallus
Domestic chicken
Ggal\LOC770974
Gallus gallus
Domestic chicken
Ggal\ENSGALG00000026134
Gallus gallus
Domestic chicken
Ggal\TMPRSS9
Gallus gallus
Domestic chicken
Ggal\LOC776414
Gallus gallus
Domestic chicken
Ggal\ENSGALG00000028082
Gallus gallus
Domestic chicken
Ggal\ENSGALG00000006081
Gallus gallus
Domestic chicken
Ggal\CORIN
Gallus gallus
Domestic chicken
Ggal\TMPRSS13
Gallus gallus
Domestic chicken
Ggal\LOC100857124
Gallus gallus
Domestic chicken
Ggal\CTRC
Gallus gallus
Domestic chicken
Ggal\ENSGALG00000027497
Gallus gallus
Domestic chicken
Ggal\ENSGALG00000010831
Gallus gallus
Domestic chicken
Ggal\ENSGALG00000009118
Gallus gallus
Domestic chicken
Ggal\ENSGALG00000028894
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v7.1)
Drosophila melanogaster (Fruit fly) (45)
Gene Symbol
Score
Source
Compara
eggNOG
Homologene
Inparanoid
Isobase
OrthoDB
OrthoFinder
orthoMCL
Panther
RoundUp
Alignment
CG7432
2 of 10
CG9372
2 of 10
CG32260
2 of 10
mas
2 of 10
CG1299
1 of 10
CG1632
1 of 10
CG1773
1 of 10
CG3355
1 of 10
CG3700
1 of 10
CG4259
1 of 10
CG4613
1 of 10
CG4914
1 of 10
CG4927
1 of 10
CG4998
1 of 10
CG6865
1 of 10
CG8170
1 of 10
CG8172
1 of 10
CG9294
1 of 10
CG9631
1 of 10
CG10041
1 of 10
CG10663
1 of 10
CG11668
1 of 10
CG11670
1 of 10
CG11836
1 of 10
CG13744
1 of 10
CG14642
1 of 10
CG14760
1 of 10
CG18477
1 of 10
CG18735
1 of 10
CG30002
1 of 10
CG30371
1 of 10
CG30375
1 of 10
CG31200
1 of 10
CG34290
1 of 10
CG34436
1 of 10
CG34437
1 of 10
flz
1 of 10
gd
1 of 10
l(2)k05911
1 of 10
Np
1 of 10
Sb
1 of 10
Ser7
1 of 10
Sp212
1 of 10
teq
1 of 10
tpr
1 of 10
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Model Summary Ribbon
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 0 )
    Human Ortholog
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Interaction
    References
    Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
     
    Disease Associations of Human Orthologs (via DIOPT v7.1 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    Functional Complementation Data
    Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
    Interactions
    Summary of Physical Interactions
    esyN Network Diagram
    Show neighbor-neighbor interactions:
    Select Layout:
    Legend:
    Protein
    RNA
    Selected Interactor(s)
    Interactions Browser
    View in Interactions Browser
    Please see the Physical Interaction reports below for full details
    protein-protein
    Physical Interaction
    Assay
    References
    ndl - cnn
    anti bait coimmunoprecipitation, peptide massfingerprinting
    (Habermann et al., 2012)
    Summary of Genetic Interactions
    esyN Network Diagram
    Starting gene(s)
    Interaction type
    Interacting gene(s)
    Reference
    Starting gene(s)
    Interaction type
    Interacting gene(s)
    Reference
    External Data
    Linkouts
    BioGRID - A database of protein and genetic interactions.
    DroID - A comprehensive database of gene and protein interactions.
    InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
    MIST (protein-protein) - An integrated Molecular Interaction Database
    Pathways
    Gene Group - Pathway Membership (FlyBase)
    Extracellular Spatzle Activating Pathway Core Components -
    In Drosophila, activation of the Toll pathway is controlled by the generation of a cleaved, active, Toll-binding form of spatzle ligand. Proteolytic activation of spatzle ligand lies downstream of several zymogen activation cascades that are initiated by different cues. In dorsal-ventral patterning, localized activation of spz results in ventral nuclear accumulation of dl. During viral and fungal and gram positive bacterial immune challenge, zymogen cascades are activated by extracellular pattern recognition receptors or virulence factor-mediated cleavage of the zymogen persephone (psh). (Adapted from FBrf0091014 and FBrf0223077).
    External Data
    Linkouts
    Genomic Location and Detailed Mapping Data
    Chromosome (arm)
    3L
    Recombination map
    3-17
    Cytogenetic map
    65B5-65B5
    Sequence location
    3L:6,593,938..6,603,366 [-]
    FlyBase Computed Cytological Location
    Cytogenetic map
    Evidence for location
    65B5-65B5
    Limits computationally determined from genome sequence between P{PZ}l(3)0209402094 and P{lacW}l(3)L4060L4060
    Experimentally Determined Cytological Location
    Cytogenetic map
    Notes
    References
    Experimentally Determined Recombination Data
    Location
    3-17
    (FlyBase, 2016, Tearle and Nusslein-Volhard, 1987)
    3-15.1
    (Comeron et al., 2012)
    Left of (cM)
    Right of (cM)
    Notes
    Stocks and Reagents
    Stocks (8)
    Genomic Clones (23)
    cDNA Clones (6)
     

    Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

    cDNA clones, fully sequences
    BDGP DGC clones
      Other clones
        Drosophila Genomics Resource Center cDNA clones

        For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

          cDNA Clones, End Sequenced (ESTs)
          BDGP DGC clones
            Other clones
              RNAi and Array Information
              Linkouts
              DRSC - Results frm RNAi screens
              GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
              Antibody Information
              Laboratory Generated Antibodies
               
              Commercially Available Antibodies
               
              Other Information
              Relationship to Other Genes
              Source for database identify of
              Source for identity of: ndl CG10129
              (Gabrielian, 1999.11)
              Source for database merge of
              Additional comments
              Other Comments
              The non-protease domains of ndl do not influence the signaling pathway that establishes embryonic DV polarity.
              (Stein et al., 2008)
              ndl has an integral role in the biogenesis of the vitelline membrane and may function in embryonic dorsal ventral patterning through creation of a matrix structure necessary for activity of the dorsal ventral protease cascade.
              (LeMosy and Hashimoto, 2000)
              Catalytic activity of the protease domain of the modular ndl protein is required for dorsoventral patterning of the embryo.
              (LeMosy et al., 2000)
              The serine protease activity of ndl protein is essential for embryonic dorsoventral polarity. Active ndl protease is generated by autoproteolytic cleavage of a zymogen form. This activation is independent of the other known proteases involved in establishment of dorsoventral polarity and appears to occur symmetrically on the surface of the embryo.
              (LeMosy et al., 1998)
              A follicular cell marker system that yields a visible phenotype within the mature egg shell allows direct comparison of a clone and its effect on the dorsal ventral pattern of the embryos. Follicular epithelium has a lack of a localised requirement for ndl protease activity.
              (Nilson and Schupbach, 1998)
              Phenotypic and genetic analysis reveals that ndl has two distinct roles important for embryogenesis: one in establishing dorsoventral polarity, the other in ensuring structural integrity of the egg.
              (Hong and Hashimoto, 1996)
              ndl is a somatic-dependent gene required to activate and localise the serine protease cascade that produces Tls ligand.
              (Hong and Hashimoto, 1995)
              Local activation of the protease cascade within the extra embryonic perivitelline compartment that defines embryonic dorsoventral polarity depends on a positional cue that is laid down during oogenesis outside the oocyte, ndl encodes an essential component of this cue. ndl function is required during oogenesis and also during the early stages of embryogenesis.
              (Hong and Hashimoto, 1995)
              Double mutant combinations of ndl with ea alleles demonstrate that spatial regulation of ea activity by localized zymogen activation is a key initial event in defining the polarity of the dorsal-ventral embryonic pattern.
              (Chasan et al., 1992)
              Strong dorsalizing mutants of ndl, snk, gd or pip have wild type axial ratios in pupae.
              (Letsou et al., 1991)
              Analysis of mosaic females indicates that the expression of ndl, pip and wbl is required in the somatic tissue, in the follicle cells that surround the oocyte, for the production of embryos with the correct dorsoventral axis.
              (Stein et al., 1991)
              Origin and Etymology
              Discoverer
              Etymology
              Identification
              External Crossreferences and Linkouts ( 32 )
              Sequence Crossreferences
              NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
              GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
              GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
              RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
              UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
              Other crossreferences
              Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
              Flygut - An atlas of the Drosophila adult midgut
              GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
              iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
              InterPro - A database of protein families, domains and functional sites
              KEGG Genes - Molecular building blocks of life in the genomic space.
              MEROPS - An information resource for peptidases (also termed proteases, proteinases and proteolytic enzymes) and the proteins that inhibit them.
              modMine - A data warehouse for the modENCODE project
              Linkouts
              BioGRID - A database of protein and genetic interactions.
              DroID - A comprehensive database of gene and protein interactions.
              DRSC - Results frm RNAi screens
              FLIGHT - Cell culture data for RNAi and other high-throughput technologies
              FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
              FlyMine - An integrated database for Drosophila genomics
              Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
              InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
              MIST (protein-protein) - An integrated Molecular Interaction Database
              Synonyms and Secondary IDs (9)
              Datasets (0)
              Study focus (0)
              Experimental Role
              Project
              Project Type
              Title
              References (142)