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Gene Dmel\ninaB

General Information
Symbol	Dmel\ninaB	Species	D. melanogaster
Name	neither inactivation nor afterpotential B	Annotation symbol	CG9347
Feature type	protein_coding_gene	FlyBase ID	FBgn0002937
Gene Model Status	Current	Stock availability	4 publicly available
Also Known As	β-diox
Genomic Location
Chromosome (arm)	3R	Recombination map	3-53.5
Cytogenetic map	87F11-87F11	Sequence location	3R:9,526,287..9,528,886 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene neither inactivation nor afterpotential B is referred to in FlyBase by the symbol Dmel\ninaB (CG9347, FBgn0002937). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: retinal isomerase activity; beta-carotene 15,15'-monooxygenase activity; carotenoid dioxygenase activity. There is experimental evidence that it is involved in the biological process: retinal metabolic process; carotene metabolic process; rhodopsin biosynthetic process; phototransduction, UV; vitamin biosynthetic process; phototransduction, visible light; vitamin A biosynthetic process. 10 alleles are reported. The phenotypes of these alleles are annotated with: photoreceptor cell R7; photoreceptor cell R2; rhabdomere; eye; photoreceptor cell R1; photoreceptor cell R6; photoreceptor cell R5; photoreceptor cell R4; photoreceptor cell R8; photoreceptor cell R3. It has one annotated transcript and one annotated polypeptide. Protein features are: Carotenoid oxygenase. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderate expression to a trough of extremely low expression. Peak expression observed during late pupal stages, in adult male stages. Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: adult head, adult eye, adult central nervous system. Comments on Affy2 ProbeSet: ProbeSet 1625743_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of ninaB. Gene sequence location is 3R:9526287..9528886.
User Contributed Data
	Beta version, feedback welcome
Phenotypic Description from the Red Book (Lindsley & Zimm 1992)
Gene/Allele symbols may differ from current usage	ninaB (J.C. Hall) Superficially like ninaA in aberrant visual physiology, but all eight photoreceptors in each eye facet affected by ninaB; can be restored to wild-type phenotype by dietary supplement of retinal but not by other retinoids.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 87F11-87F11   Limits computationally determined from genome sequence between P{PZ}flfl01949 and P{lacW}trxj14A6&P{PZ}trx00347
Experimentally Determined Cytological Location
Cytogenetic map Notes References 87F-87F     (Sagara, 2000.4.7)
Experimentally Determined Recombination Data
Location	3-53.5
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\ninaB for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.47
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) ninaB-RA FBtr0082820  NM_142050   2164   620
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein ninaB-PA   FBpp0082288   69.9   620   6.78     NP_650307   AAF54978
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Carotenoid oxygenase (IPR004294)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AE014297 AAF54978   AB041507 BAA94508   AI063857   AJ276682 CAB93141   AW940152   AX189541 CAC50772   AX189675 CAC50781   AY121617 AAM51944   CO293591   CO340318   CO340605   EC086547   EC259256   GH973812   GH978563   GH979865   GH981378   GH982125
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q9VFS2 Q9NKW9
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
expression microarray Stage Tissue/Position (including subcellular localization) Reference adult stage   eye   (Xu et al., 2004) in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage 13 -- 16   Bolwig organ   (Fisher et al., 2012) adult stage   neuron | subset of adult brain   • nucleus (Yang and O'Tousa, 2007) optic lobe neuron   (Yang and O'Tousa, 2007) RT-PCR Stage Tissue/Position (including subcellular localization) Reference adult stage   adult head   (Yang and O'Tousa, 2007)
Additional Descriptive Data
	Eye-enriched transcripts determined by ratio of expression level in wild-type heads. versus expression level in so heads. (Xu et al., 2004)
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: adult head, adult eye, adult central nervous system. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    7.1 Larval Midgut    2.2 Larval Hindgut    5.7 Larval Malpighian Tubules    2.9 Larval Fat Body    6.6 Larval Salivary Gland    3.2 Larval Trachea    17.275 Larval Carcass    7.55 Adult Head    621 Adult Eye    1422.15 Adult Brain    501.1 Adult Thoracic-Abdominal Ganglion    503.5 Adult Crop    9.1 Adult Midgut    3.7 Adult Hindgut    9.7 Adult Malpighian Tubules    4.4 Adult Fat Body    8.8 Adult Salivary Gland    7.6 Adult Heart    3.95 Adult VirginFemale Spermatheca    7.7 Adult InseminatedFemale Spermatheca    9.2 Adult Ovary    3.3 Adult Testis    3.8 Adult Male Accessory Gland    3.9 Adult Carcass    11.8 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    7.1 Larval Midgut    2.2 Larval Hindgut    5.7 Larval Malpighian Tubules    2.9 Larval Fat Body    6.6 Larval Salivary Gland    3.2 Larval Trachea    17.275 Larval Carcass    7.55 Adult Head  (621) Adult Eye  (1422.15) Adult Brain  501.1 Adult Thoracic-Abdominal Ganglion  503.5 Adult Crop    9.1 Adult Midgut    3.7 Adult Hindgut    9.7 Adult Malpighian Tubules    4.4 Adult Fat Body    8.8 Adult Salivary Gland    7.6 Adult Heart    3.95 Adult VirginFemale Spermatheca    7.7 Adult InseminatedFemale Spermatheca    9.2 Adult Ovary    3.3 Adult Testis    3.8 Adult Male Accessory Gland    3.9 Adult Carcass    11.8 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    7.1 Larval Midgut    2.2 Larval Hindgut    5.7 Larval Malpighian Tubules    2.9 Larval Fat Body    6.6 Larval Salivary Gland    3.2 Larval Trachea    17.275 Larval Carcass    7.55 Adult Head    621 Adult Eye  (1422.15) Adult Brain    501.1 Adult Thoracic-Abdominal Ganglion    503.5 Adult Crop    9.1 Adult Midgut    3.7 Adult Hindgut    9.7 Adult Malpighian Tubules    4.4 Adult Fat Body    8.8 Adult Salivary Gland    7.6 Adult Heart    3.95 Adult VirginFemale Spermatheca    7.7 Adult InseminatedFemale Spermatheca    9.2 Adult Ovary    3.3 Adult Testis    3.8 Adult Male Accessory Gland    3.9 Adult Carcass    11.8 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    7.1 Larval Midgut    2.2 Larval Hindgut    5.7 Larval Malpighian Tubules    2.9 Larval Fat Body    6.6 Larval Salivary Gland    3.2 Larval Trachea    17.275 Larval Carcass    7.55 Adult Head    621 Adult Eye    1422.15 Adult Brain    501.1 Adult Thoracic-Abdominal Ganglion    503.5 Adult Crop    9.1 Adult Midgut    3.7 Adult Hindgut    9.7 Adult Malpighian Tubules    4.4 Adult Fat Body    8.8 Adult Salivary Gland    7.6 Adult Heart    3.95 Adult VirginFemale Spermatheca    7.7 Adult InseminatedFemale Spermatheca    9.2 Adult Ovary    3.3 Adult Testis    3.8 Adult Male Accessory Gland    3.9 Adult Carcass    11.8 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    7.1 Larval Midgut    2.2 Larval Hindgut    5.7 Larval Malpighian Tubules    2.9 Larval Fat Body    6.6 Larval Salivary Gland    3.2 Larval Trachea    17.275 Larval Carcass    7.55 Adult Head    621 Adult Eye    1422.15 Adult Brain    501.1 Adult Thoracic-Abdominal Ganglion    503.5 Adult Crop    9.1 Adult Midgut    3.7 Adult Hindgut    9.7 Adult Malpighian Tubules    4.4 Adult Fat Body    8.8 Adult Salivary Gland    7.6 Adult Heart    3.95 Adult VirginFemale Spermatheca    7.7 Adult InseminatedFemale Spermatheca    9.2 Adult Ovary    3.3 Adult Testis    3.8 Adult Male Accessory Gland    3.9 Adult Carcass    11.8 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    7.1 Larval Midgut    2.2 Larval Hindgut    5.7 Larval Malpighian Tubules    2.9 Larval Fat Body    6.6 Larval Salivary Gland    3.2 Larval Trachea    17.275 Larval Carcass    7.55 Adult Head  621 Adult Eye  (1422.15) Adult Brain  501.1 Adult Thoracic-Abdominal Ganglion  503.5 Adult Crop    9.1 Adult Midgut    3.7 Adult Hindgut    9.7 Adult Malpighian Tubules    4.4 Adult Fat Body    8.8 Adult Salivary Gland    7.6 Adult Heart    3.95 Adult VirginFemale Spermatheca    7.7 Adult InseminatedFemale Spermatheca    9.2 Adult Ovary    3.3 Adult Testis    3.8 Adult Male Accessory Gland    3.9 Adult Carcass    11.8 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    7.1 Larval Midgut    2.2 Larval Hindgut    5.7 Larval Malpighian Tubules    2.9 Larval Fat Body    6.6 Larval Salivary Gland    3.2 Larval Trachea    17.275 Larval Carcass    7.55 Adult Head    621 Adult Eye  1422.15 Adult Brain    501.1 Adult Thoracic-Abdominal Ganglion    503.5 Adult Crop    9.1 Adult Midgut    3.7 Adult Hindgut    9.7 Adult Malpighian Tubules    4.4 Adult Fat Body    8.8 Adult Salivary Gland    7.6 Adult Heart    3.95 Adult VirginFemale Spermatheca    7.7 Adult InseminatedFemale Spermatheca    9.2 Adult Ovary    3.3 Adult Testis    3.8 Adult Male Accessory Gland    3.9 Adult Carcass    11.8 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    7.1 Larval Midgut    2.2 Larval Hindgut    5.7 Larval Malpighian Tubules    2.9 Larval Fat Body    6.6 Larval Salivary Gland    3.2 Larval Trachea    17.275 Larval Carcass    7.55 Adult Head    621 Adult Eye    1422.15 Adult Brain    501.1 Adult Thoracic-Abdominal Ganglion    503.5 Adult Crop    9.1 Adult Midgut    3.7 Adult Hindgut    9.7 Adult Malpighian Tubules    4.4 Adult Fat Body    8.8 Adult Salivary Gland    7.6 Adult Heart    3.95 Adult VirginFemale Spermatheca    7.7 Adult InseminatedFemale Spermatheca    9.2 Adult Ovary    3.3 Adult Testis    3.8 Adult Male Accessory Gland    3.9 Adult Carcass    11.8 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    621   NA  Eye    1422.15   NA  Brain    501.1   7.1  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    503.5   NA  Crop    9.1   2.2  Midgut    3.7   5.7  Hindgut    9.7   2.9  Malpighian Tubules    4.4   6.6  Fat Body    8.8   3.2  Salivary Gland    7.6   NA  Heart    3.95   no informative data  Trachea    NA   NA  VirginFemale Spermatheca    7.7   NA  InseminatedFemale Spermatheca    9.2   NA  Ovary    3.3   NA  Testis    3.8   NA  Male Accessory Gland    3.9   7.55  Carcass    no informative data FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    0 central nervous system, larvae L3    0 central nervous system, pupae P8    0 head, virgin 1-day female    18 head, virgin 4-day female    14 head, virgin 20-day female    15 head, mated 1-day female    10 head, mated 4-day female    16 head, mated 20-day female    11 head, mated 1-day male    22 head, mated 4-day male    30 head, mated 20-day male    29 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    0 fat body, pupae P8    3 carcass, larvae L3 wandering    0 carcass, 1-day adult    0 carcass, 4-day adult    0 carcass, 20-day adult    0 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    0 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    0 central nervous system, larvae L3    0 central nervous system, pupae P8    0 head, virgin 1-day female    18 head, virgin 4-day female    14 head, virgin 20-day female    15 head, mated 1-day female    10 head, mated 4-day female    16 head, mated 20-day female    11 head, mated 1-day male    22 head, mated 4-day male  (30) head, mated 20-day male  (29) salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    0 fat body, pupae P8    3 carcass, larvae L3 wandering    0 carcass, 1-day adult    0 carcass, 4-day adult    0 carcass, 20-day adult    0 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    0 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    0 central nervous system, larvae L3    0 central nervous system, pupae P8    0 head, virgin 1-day female    18 head, virgin 4-day female    14 head, virgin 20-day female    15 head, mated 1-day female    10 head, mated 4-day female    16 head, mated 20-day female    11 head, mated 1-day male    22 head, mated 4-day male    30 head, mated 20-day male    29 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    0 fat body, pupae P8    3 carcass, larvae L3 wandering    0 carcass, 1-day adult    0 carcass, 4-day adult    0 carcass, 20-day adult    0 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    0 central nervous system, larvae L3    0 central nervous system, pupae P8    0 head, virgin 1-day female    18 head, virgin 4-day female    14 head, virgin 20-day female    15 head, mated 1-day female    10 head, mated 4-day female    16 head, mated 20-day female    11 head, mated 1-day male    22 head, mated 4-day male    30 head, mated 20-day male    29 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    0 fat body, pupae P8    3 carcass, larvae L3 wandering    0 carcass, 1-day adult    0 carcass, 4-day adult    0 carcass, 20-day adult    0 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    0 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    0 central nervous system, larvae L3    0 central nervous system, pupae P8    0 head, virgin 1-day female    18 head, virgin 4-day female    14 head, virgin 20-day female    15 head, mated 1-day female    10 head, mated 4-day female    16 head, mated 20-day female    11 head, mated 1-day male    22 head, mated 4-day male    30 head, mated 20-day male    29 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    0 fat body, pupae P8    3 carcass, larvae L3 wandering    0 carcass, 1-day adult    0 carcass, 4-day adult    0 carcass, 20-day adult    0 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    0 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    0 central nervous system, larvae L3    0 central nervous system, pupae P8    0 head, virgin 1-day female    18 head, virgin 4-day female    14 head, virgin 20-day female    15 head, mated 1-day female    10 head, mated 4-day female    16 head, mated 20-day female    11 head, mated 1-day male    22 head, mated 4-day male  30 head, mated 20-day male  29 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    0 fat body, pupae P8    3 carcass, larvae L3 wandering    0 carcass, 1-day adult    0 carcass, 4-day adult    0 carcass, 20-day adult    0 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    0 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    0 central nervous system, larvae L3    0 central nervous system, pupae P8    0 head, virgin 1-day female    18 head, virgin 4-day female    14 head, virgin 20-day female    15 head, mated 1-day female    10 head, mated 4-day female    16 head, mated 20-day female    11 head, mated 1-day male    22 head, mated 4-day male    30 head, mated 20-day male    29 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    0 fat body, pupae P8    3 carcass, larvae L3 wandering    0 carcass, 1-day adult    0 carcass, 4-day adult    0 carcass, 20-day adult    0 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    0 central nervous system, larvae L3    0 central nervous system, pupae P8    0 head, virgin 1-day female    18 head, virgin 4-day female    14 head, virgin 20-day female    15 head, mated 1-day female    10 head, mated 4-day female    16 head, mated 20-day female    11 head, mated 1-day male    22 head, mated 4-day male    30 head, mated 20-day male    29 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    0 fat body, pupae P8    3 carcass, larvae L3 wandering    0 carcass, 1-day adult    0 carcass, 4-day adult    0 carcass, 20-day adult    0 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderate expression to a trough of extremely low expression. Peak expression observed during late pupal stages, in adult male stages. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    0 embryo 10-12hr    0 embryo 12-14hr    0 embryo 14-16hr    0 embryo 16-18hr    0 embryo 18-20hr    1 embryo 20-22hr    1 embryo 22-24hr    1 larva L1    0 larva L2    0 larva L3 12hr old    0 larva L3 puffstage 1-2    0 larva L3 puffstage 3-6    0 larva L3 puffstage 7-9    0 white prepupae new    0 white prepupae 12hr    1 white prepupae 24hr    1 pupae 2d postWPP    1 pupae 3d postWPP    7 pupae 4d postWPP    7 adult male 01day    9 adult male 05day    8 adult male 30day    9 adult female 01day    5 adult female 05day    2 adult female 30day    1 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    0 embryo 10-12hr    0 embryo 12-14hr    0 embryo 14-16hr    0 embryo 16-18hr    0 embryo 18-20hr    1 embryo 20-22hr    1 embryo 22-24hr    1 larva L1    0 larva L2    0 larva L3 12hr old    0 larva L3 puffstage 1-2    0 larva L3 puffstage 3-6    0 larva L3 puffstage 7-9    0 white prepupae new    0 white prepupae 12hr    1 white prepupae 24hr    1 pupae 2d postWPP    1 pupae 3d postWPP    7 pupae 4d postWPP    7 adult male 01day    9 adult male 05day    8 adult male 30day    9 adult female 01day    5 adult female 05day    2 adult female 30day    1 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    0 embryo 10-12hr    0 embryo 12-14hr    0 embryo 14-16hr    0 embryo 16-18hr    0 embryo 18-20hr    1 embryo 20-22hr    1 embryo 22-24hr    1 larva L1    0 larva L2    0 larva L3 12hr old    0 larva L3 puffstage 1-2    0 larva L3 puffstage 3-6    0 larva L3 puffstage 7-9    0 white prepupae new    0 white prepupae 12hr    1 white prepupae 24hr    1 pupae 2d postWPP    1 pupae 3d postWPP    7 pupae 4d postWPP    7 adult male 01day    9 adult male 05day    8 adult male 30day    9 adult female 01day    5 adult female 05day    2 adult female 30day    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    0 embryo 10-12hr    0 embryo 12-14hr    0 embryo 14-16hr    0 embryo 16-18hr    0 embryo 18-20hr    1 embryo 20-22hr    1 embryo 22-24hr    1 larva L1    0 larva L2    0 larva L3 12hr old    0 larva L3 puffstage 1-2    0 larva L3 puffstage 3-6    0 larva L3 puffstage 7-9    0 white prepupae new    0 white prepupae 12hr    1 white prepupae 24hr    1 pupae 2d postWPP    1 pupae 3d postWPP    7 pupae 4d postWPP    7 adult male 01day    9 adult male 05day    8 adult male 30day    9 adult female 01day    5 adult female 05day    2 adult female 30day    1 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    0 embryo 10-12hr    0 embryo 12-14hr    0 embryo 14-16hr    0 embryo 16-18hr    0 embryo 18-20hr    1 embryo 20-22hr    1 embryo 22-24hr    1 larva L1    0 larva L2    0 larva L3 12hr old    0 larva L3 puffstage 1-2    0 larva L3 puffstage 3-6    0 larva L3 puffstage 7-9    0 white prepupae new    0 white prepupae 12hr    1 white prepupae 24hr    1 pupae 2d postWPP    1 pupae 3d postWPP    7 pupae 4d postWPP    7 adult male 01day    9 adult male 05day    8 adult male 30day    9 adult female 01day    5 adult female 05day    2 adult female 30day    1 Expression Level Scale  Very low   Low   Moderate  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    0 embryo 10-12hr    0 embryo 12-14hr    0 embryo 14-16hr    0 embryo 16-18hr    0 embryo 18-20hr    1 embryo 20-22hr    1 embryo 22-24hr    1 larva L1    0 larva L2    0 larva L3 12hr old    0 larva L3 puffstage 1-2    0 larva L3 puffstage 3-6    0 larva L3 puffstage 7-9    0 white prepupae new    0 white prepupae 12hr    1 white prepupae 24hr    1 pupae 2d postWPP    1 pupae 3d postWPP    7 pupae 4d postWPP    7 adult male 01day    9 adult male 05day    8 adult male 30day    9 adult female 01day    5 adult female 05day    2 adult female 30day    1 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    0 embryo 10-12hr    0 embryo 12-14hr    0 embryo 14-16hr    0 embryo 16-18hr    0 embryo 18-20hr    1 embryo 20-22hr    1 embryo 22-24hr    1 larva L1    0 larva L2    0 larva L3 12hr old    0 larva L3 puffstage 1-2    0 larva L3 puffstage 3-6    0 larva L3 puffstage 7-9    0 white prepupae new    0 white prepupae 12hr    1 white prepupae 24hr    1 pupae 2d postWPP    1 pupae 3d postWPP    7 pupae 4d postWPP    7 adult male 01day    9 adult male 05day    8 adult male 30day    9 adult female 01day    5 adult female 05day    2 adult female 30day    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    0 embryo 10-12hr    0 embryo 12-14hr    0 embryo 14-16hr    0 embryo 16-18hr    0 embryo 18-20hr    1 embryo 20-22hr    1 embryo 22-24hr    1 larva L1    0 larva L2    0 larva L3 12hr old    0 larva L3 puffstage 1-2    0 larva L3 puffstage 3-6    0 larva L3 puffstage 7-9    0 white prepupae new    0 white prepupae 12hr    1 white prepupae 24hr    1 pupae 2d postWPP    1 pupae 3d postWPP    7 pupae 4d postWPP    7 adult male 01day    9 adult male 05day    8 adult male 30day    9 adult female 01day    5 adult female 05day    2 adult female 30day    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    0 cold shock, 4-day adult    0 heat shock, 4-day adult    0 Cadmium 50 mM 6 hrs, larvae L3    0 Cadmium 50 mM 12 hrs, larvae L3    0 Cadmium 50 mM 48 hrs, 4-day adult    0 Cadmium 100 mM 48 hrs, 4-day adult    0 Copper 0.5 mM 12 hrs, larvae L3    0 Copper 15 mM 48 hrs, 4-day adult    0 Zinc 5 mM 12 hrs, larvae L3    0 Zinc 4.5 mM 48 hrs, 4-day adult    1 Ethanol 2.5% 3 hrs, larvae L3    1 Ethanol 5% 3 hrs, larvae L3    0 Ethanol 10% 3 hrs, larvae L3    0 Caffeine 1.5 mg/ml 4 hrs, larvae L3    0 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    0 Caffeine 25 mg/ml 48 hrs, 4-day adult    0 Paraquat 5 mM 48 hrs, 4-day adult    1 Paraquat 10 mM 48 hrs, 4-day adult    2 Rotenone 2 μg 12 hrs, larvae L3    0 Rotenone 8 μg 12 hrs, larvae L3    0 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    0 cold shock, 4-day adult    0 heat shock, 4-day adult    0 Cadmium 50 mM 6 hrs, larvae L3    0 Cadmium 50 mM 12 hrs, larvae L3    0 Cadmium 50 mM 48 hrs, 4-day adult    0 Cadmium 100 mM 48 hrs, 4-day adult    0 Copper 0.5 mM 12 hrs, larvae L3    0 Copper 15 mM 48 hrs, 4-day adult    0 Zinc 5 mM 12 hrs, larvae L3    0 Zinc 4.5 mM 48 hrs, 4-day adult    1 Ethanol 2.5% 3 hrs, larvae L3    1 Ethanol 5% 3 hrs, larvae L3    0 Ethanol 10% 3 hrs, larvae L3    0 Caffeine 1.5 mg/ml 4 hrs, larvae L3    0 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    0 Caffeine 25 mg/ml 48 hrs, 4-day adult    0 Paraquat 5 mM 48 hrs, 4-day adult    1 Paraquat 10 mM 48 hrs, 4-day adult    2 Rotenone 2 μg 12 hrs, larvae L3    0 Rotenone 8 μg 12 hrs, larvae L3    0 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    0 cold shock, 4-day adult    0 heat shock, 4-day adult    0 Cadmium 50 mM 6 hrs, larvae L3    0 Cadmium 50 mM 12 hrs, larvae L3    0 Cadmium 50 mM 48 hrs, 4-day adult    0 Cadmium 100 mM 48 hrs, 4-day adult    0 Copper 0.5 mM 12 hrs, larvae L3    0 Copper 15 mM 48 hrs, 4-day adult    0 Zinc 5 mM 12 hrs, larvae L3    0 Zinc 4.5 mM 48 hrs, 4-day adult    1 Ethanol 2.5% 3 hrs, larvae L3    1 Ethanol 5% 3 hrs, larvae L3    0 Ethanol 10% 3 hrs, larvae L3    0 Caffeine 1.5 mg/ml 4 hrs, larvae L3    0 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    0 Caffeine 25 mg/ml 48 hrs, 4-day adult    0 Paraquat 5 mM 48 hrs, 4-day adult    1 Paraquat 10 mM 48 hrs, 4-day adult    2 Rotenone 2 μg 12 hrs, larvae L3    0 Rotenone 8 μg 12 hrs, larvae L3    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    0 cold shock, 4-day adult    0 heat shock, 4-day adult    0 Cadmium 50 mM 6 hrs, larvae L3    0 Cadmium 50 mM 12 hrs, larvae L3    0 Cadmium 50 mM 48 hrs, 4-day adult    0 Cadmium 100 mM 48 hrs, 4-day adult    0 Copper 0.5 mM 12 hrs, larvae L3    0 Copper 15 mM 48 hrs, 4-day adult    0 Zinc 5 mM 12 hrs, larvae L3    0 Zinc 4.5 mM 48 hrs, 4-day adult    1 Ethanol 2.5% 3 hrs, larvae L3    1 Ethanol 5% 3 hrs, larvae L3    0 Ethanol 10% 3 hrs, larvae L3    0 Caffeine 1.5 mg/ml 4 hrs, larvae L3    0 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    0 Caffeine 25 mg/ml 48 hrs, 4-day adult    0 Paraquat 5 mM 48 hrs, 4-day adult    1 Paraquat 10 mM 48 hrs, 4-day adult    2 Rotenone 2 μg 12 hrs, larvae L3    0 Rotenone 8 μg 12 hrs, larvae L3    0 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    0 cold shock, 4-day adult    0 heat shock, 4-day adult    0 Cadmium 50 mM 6 hrs, larvae L3    0 Cadmium 50 mM 12 hrs, larvae L3    0 Cadmium 50 mM 48 hrs, 4-day adult    0 Cadmium 100 mM 48 hrs, 4-day adult    0 Copper 0.5 mM 12 hrs, larvae L3    0 Copper 15 mM 48 hrs, 4-day adult    0 Zinc 5 mM 12 hrs, larvae L3    0 Zinc 4.5 mM 48 hrs, 4-day adult    1 Ethanol 2.5% 3 hrs, larvae L3    1 Ethanol 5% 3 hrs, larvae L3    0 Ethanol 10% 3 hrs, larvae L3    0 Caffeine 1.5 mg/ml 4 hrs, larvae L3    0 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    0 Caffeine 25 mg/ml 48 hrs, 4-day adult    0 Paraquat 5 mM 48 hrs, 4-day adult    1 Paraquat 10 mM 48 hrs, 4-day adult    2 Rotenone 2 μg 12 hrs, larvae L3    0 Rotenone 8 μg 12 hrs, larvae L3    0 Expression Level Scale  Very low   Low   Moderate  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    0 cold shock, 4-day adult    0 heat shock, 4-day adult    0 Cadmium 50 mM 6 hrs, larvae L3    0 Cadmium 50 mM 12 hrs, larvae L3    0 Cadmium 50 mM 48 hrs, 4-day adult    0 Cadmium 100 mM 48 hrs, 4-day adult    0 Copper 0.5 mM 12 hrs, larvae L3    0 Copper 15 mM 48 hrs, 4-day adult    0 Zinc 5 mM 12 hrs, larvae L3    0 Zinc 4.5 mM 48 hrs, 4-day adult    1 Ethanol 2.5% 3 hrs, larvae L3    1 Ethanol 5% 3 hrs, larvae L3    0 Ethanol 10% 3 hrs, larvae L3    0 Caffeine 1.5 mg/ml 4 hrs, larvae L3    0 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    0 Caffeine 25 mg/ml 48 hrs, 4-day adult    0 Paraquat 5 mM 48 hrs, 4-day adult    1 Paraquat 10 mM 48 hrs, 4-day adult    2 Rotenone 2 μg 12 hrs, larvae L3    0 Rotenone 8 μg 12 hrs, larvae L3    0 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    0 cold shock, 4-day adult    0 heat shock, 4-day adult    0 Cadmium 50 mM 6 hrs, larvae L3    0 Cadmium 50 mM 12 hrs, larvae L3    0 Cadmium 50 mM 48 hrs, 4-day adult    0 Cadmium 100 mM 48 hrs, 4-day adult    0 Copper 0.5 mM 12 hrs, larvae L3    0 Copper 15 mM 48 hrs, 4-day adult    0 Zinc 5 mM 12 hrs, larvae L3    0 Zinc 4.5 mM 48 hrs, 4-day adult    1 Ethanol 2.5% 3 hrs, larvae L3    1 Ethanol 5% 3 hrs, larvae L3    0 Ethanol 10% 3 hrs, larvae L3    0 Caffeine 1.5 mg/ml 4 hrs, larvae L3    0 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    0 Caffeine 25 mg/ml 48 hrs, 4-day adult    0 Paraquat 5 mM 48 hrs, 4-day adult    1 Paraquat 10 mM 48 hrs, 4-day adult    2 Rotenone 2 μg 12 hrs, larvae L3    0 Rotenone 8 μg 12 hrs, larvae L3    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    0 cold shock, 4-day adult    0 heat shock, 4-day adult    0 Cadmium 50 mM 6 hrs, larvae L3    0 Cadmium 50 mM 12 hrs, larvae L3    0 Cadmium 50 mM 48 hrs, 4-day adult    0 Cadmium 100 mM 48 hrs, 4-day adult    0 Copper 0.5 mM 12 hrs, larvae L3    0 Copper 15 mM 48 hrs, 4-day adult    0 Zinc 5 mM 12 hrs, larvae L3    0 Zinc 4.5 mM 48 hrs, 4-day adult    1 Ethanol 2.5% 3 hrs, larvae L3    1 Ethanol 5% 3 hrs, larvae L3    0 Ethanol 10% 3 hrs, larvae L3    0 Caffeine 1.5 mg/ml 4 hrs, larvae L3    0 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    0 Caffeine 25 mg/ml 48 hrs, 4-day adult    0 Paraquat 5 mM 48 hrs, 4-day adult    1 Paraquat 10 mM 48 hrs, 4-day adult    2 Rotenone 2 μg 12 hrs, larvae L3    0 Rotenone 8 μg 12 hrs, larvae L3    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010, Graveley et al., 2011) mE2_34_mRNA_expression_cluster_00 mE1_20_mRNA_expression_cluster_20
External Data & Images
Linkouts	BDGP expression data • GH03958 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0002937 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG9347-RA FlyExpress - Embryonic expression images (BDGP data) • Show all FlyExpress processed images for ninaB Stages(s) 11-12 Stages(s) 13-16
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele viable, with Scer\GAL4pnr-MD237 ninaBGD14195 Other Phenotypes Allele courtship behavior defective | male ninaB3 neurophysiology defective ninaB1 phototaxis defective | third instar larval stage ninaB3 Phenotype manifest in Allele eye ninaB3 photoreceptor cell R1 ninaB1 photoreceptor cell R2 ninaB1 photoreceptor cell R3 ninaB1 photoreceptor cell R4 ninaB1 photoreceptor cell R5 ninaB1 photoreceptor cell R6 ninaB1 photoreceptor cell R7 ninaB1 photoreceptor cell R8 ninaB1 rhabdomere ninaB3
Classical Alleles ( 3 )
For All Classical Alleles Show
Allele of ninaB Class Mutagen Stocks Known lesion ninaB1 ethyl methanesulfonate 1 Yes ninaB2 ethyl methanesulfonate 0 -- ninaB3 ethyl methanesulfonate 0 Yes
Alleles Carried on Transgenic Constructs ( 7 )
For All Alleles Carried on Transgenic Constructs Show
Allele of ninaB Class Mutagen Stocks Known lesion ninaBGD14195 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes ninaBHMS01404 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes ninaBKK102352 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes ninaBScer\UAS.cGa in vitro construct - regulatory fusion 1 Yes ninaBhs.PG in vitro construct - regulatory fusion 0 Yes ninaBNIG.9347R in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes ninaBScer\UAS.cVa in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(3R)Exel6170 (Ryder, 2004.4.26)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data GAL4 construct P{ninaB-GAL4.W} No P{ninaB-GAL4.Y} No UAS construct P{GD14195} NA P{KK102352} NA P{NIG.9347R} NA P{TRiP.HMS01404} NA P{UAS-ninaB.G} NA P{UAS-ninaB.V} NA heat-shock construct P{hs-ninaB.G} NA
Insertions
	Type of insertions Name Expression data
Gene Ontology: Function, Process & Cellular Component ( 11 unique terms )
Terms Based on Experimental Evidence ( 10 terms )
Molecular Function
CV term Evidence References
beta-carotene 15,15'-monooxygenase activity inferred from direct assay AND inferred from mutant phenotype (von Lintig et al., 2001) carotenoid dioxygenase activity inferred from direct assay (Oberhauser et al., 2008) retinal isomerase activity inferred from direct assay (Oberhauser et al., 2008)
Biological Process
CV term Evidence References
carotene metabolic process inferred from direct assay (von Lintig et al., 2001, Oberhauser et al., 2008) phototransduction, UV inferred from mutant phenotype (Stephenson et al., 1983) phototransduction, visible light inferred from mutant phenotype (Stephenson et al., 1983) retinal metabolic process inferred from direct assay (Oberhauser et al., 2008) rhodopsin biosynthetic process inferred from direct assay (Oberhauser et al., 2008) inferred from mutant phenotype (Stephenson et al., 1983) vitamin A biosynthetic process inferred from direct assay AND inferred from mutant phenotype (von Lintig et al., 2001) vitamin biosynthetic process inferred from mutant phenotype (von Lintig et al., 2001)
Cellular Component ( 0 terms)
Terms Based on Predictions or Assertions ( 2 terms )
Molecular Function
CV term Evidence References
beta-carotene 15,15'-monooxygenase activity non-traceable author statement (von Lintig, 2000.3.14)
Biological Process
CV term Evidence References
phototransduction traceable author statement (Montell, 1999)
Cellular Component ( 0 terms)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions ninaB allele Gene References
External Data
Linkouts	DPiM - DPiM, Drosophila Protein interaction Map • FBgn0002937 DroID - A comprehensive database of gene and protein interactions. • FBgn0002937 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 41678
Orthologs
OrthoDB Orthologs (61) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG64F6VM Dipteran inclusive ortholog search EOG6VHKFK Insect inclusive ortholog search EOG68PKF6 Arthropod inclusive ortholog search EOG6QZ61X Metazoa inclusive ortholog search EOG6FFRV7
Orthologs in Drosophila Species (EOG64F6VM)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\ninaB     Drosophila simulans   Dsim\GD18923 Y   Drosophila sechellia   Dsec\GM24124 Y   Drosophila erecta   Dere\GG19789 Y   Drosophila yakuba   Dyak\GE26290 Y   Drosophila ananassae   Dana\GF16875 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA21719 Y   Drosophila persimilis   Dper\GL23083 Y   Drosophila willistoni   Dwil\GK14193 Y   Drosophila virilis   Dvir\GJ14471 Y   Drosophila mojavensis   Dmoj\GI23158 Y   Drosophila grimshawi   Dgri\GH14266 Y
Orthologs in non-Drosophila Dipterans (EOG6VHKFK)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL003211   Anopheles gambiae Malaria mosquito  Agam\AGAP008143   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ801511
Orthologs in non-Dipteran Insects (EOG68PKF6)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\GB52785   Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG015147   Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH19941   Atta cephalotes Leafcutter ant  Acep\ACEP22255   Camponotus floridanus Florida carpenter ant  Cflo\CFLO13586   Camponotus floridanus Florida carpenter ant  Cflo\CFLO13587   Camponotus floridanus Florida carpenter ant  Cflo\CFLO20020   Camponotus floridanus Florida carpenter ant  Cflo\CFLO13585   Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL17775   Linepithema humile Argentine ant  Lhum\LH24645   Pogonomyrmex barbatus Red harvester ant  Pbar\PB21991   Solenopsis invicta Red fire ant  Sinv\SINV12633   Acyrthosiphon pisum Pea aphid  Apim\ACYPI009634   Bombyx mori Silkmoth  Bmor\BGIBMGA005193   Tribolium castaneum Red flour beetle  Tcas\TC016092
Orthologs in non-Insect Arthropods (EOG6QZ61X)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\PRSS53   Ixodes scapularis Deer tick  Isca\ISCW021869
Orthologs in non-Arthropod Metazoa (EOG6FFRV7)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Caenorhabditis elegans Nematode  Cele\bcmo-1   Caenorhabditis elegans Nematode  Cele\bcmo-2   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_028139gn   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_024765gn   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_024058gn   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_016609gn   Danio rerio Zebrafish  Drer\rpe65b   Danio rerio Zebrafish  Drer\bcdo2l   Danio rerio Zebrafish  Drer\bco2a   Danio rerio Zebrafish  Drer\bcmo1   Danio rerio Zebrafish  Drer\rpe65a   Danio rerio Zebrafish  Drer\bco2b   Danio rerio Zebrafish  Drer\ENSDARG00000054420   Danio rerio Zebrafish  Drer\ENSDARG00000029446   Xenopus tropicalis Western clawed frog  Xtro\bco2   Xenopus tropicalis Western clawed frog  Xtro\rpe65   Xenopus tropicalis Western clawed frog  Xtro\ENSXETG00000026012   Gallus gallus Domestic chicken  Ggal\BCDO2   Gallus gallus Domestic chicken  Ggal\RPE65   Gallus gallus Domestic chicken  Ggal\BCMO1   Mus musculus House mouse  Mmus\Bcmo1   Mus musculus House mouse  Mmus\ENSMUSG00000028174   Mus musculus House mouse  Mmus\Bco2   Rattus norvegicus Norway rat  Rnor\Bcmo1   Rattus norvegicus Norway rat  Rnor\Bco2   Rattus norvegicus Norway rat  Rnor\ENSRNOG00000009582   Homo sapiens Human  Hsap\RPE65   Homo sapiens Human  Hsap\BCMO1   Homo sapiens Human  Hsap\BCO2
Human Orthologs (3)
Gene OMIM HGNC Hsap\RPE65     Hsap\BCMO1     Hsap\BCO2
AAA Orthologs (11) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD18923 Drosophila sechellia Dsec\GM24124 Drosophila erecta Dere\GG19789 Drosophila yakuba Dyak\GE26290 Drosophila ananassae Dana\GF16875 Drosophila pseudoobscura pseudoobscura Dpse\GA21719 Drosophila persimilis Dper\GL23083 Drosophila willistoni Dwil\GK14193 Drosophila virilis Dvir\GJ14471 Drosophila mojavensis Dmoj\GI23158 Drosophila grimshawi Dgri\GH14266
Stocks & Reagents
Stocks Listed in FlyBase ( 4 )
Bloomington	34994 y1 sc* v1; P{TRiP.HMS01404}attP2 24776 w*/Dp(1;Y)y+; ninaB1, P{UAS-ninaB.G}3
VDRC	v104683 P{KK102352}VIE-260B v29108 w1118; P{GD14195}v29108/CyO
Genomic Clones ( 2 )
	BACR03J04 BACR30G22 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 12 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	GH03958
Other clones	DPiM_GH03958
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones
Other clones	71545 214511.33 EK203807 EP10422 EP11001 RP004225045 RP004232195 RP004244591 RP004259481 RP004375550
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0002937 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 41678
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: RPE65 CG9347 (FlyBase, 1996-)
Source for database merge of	Source for merge of: ninaB RPE65 (von Lintig et al., 2001) Source for merge of: RPE65 β-diox (FlyBase, 1996-)
Additional comments	Source for merge of RPE65 β-diox was sequence comparison (date:000608). (FlyBase, 1996-) Source for identity of RPE65 CG9347 was sequence comparison (date:000414). (FlyBase, 1996-)
Other Comments
	ninaB and ninaD are not required in the retina, and exclusive retinal expression of either ninaB or ninaD, or both genes simultaneously, does not support rhodopsin biogenesis. Neuron-specific expression of ninaB and ninaD allows for rhodopsin biogenesis. (Gu et al., 2004) ninaB has a key role in the synthesis of vitamin A. (von Lintig et al., 2001)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_142050 RefSeq (Proteins) • NP_650307 DDBJ / EMBL / GenBank • AAF54978 AAM51944 AB041507 AI063857 AJ276682 AW940152 AX189541 AX189675 AY121617 BAA94508 CAB93141 CAC50772 CAC50781 Entrez Gene - A searchable database of RefSeq genes. • 41678 UniProtKB/TrEMBL • Q9NKW9 Q9VFS2
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Carotenoid oxygenase (IPR004294) BDGP expression data - Patterns of gene expression in Drosophila embryogenesis • GH03958
Linkouts
	DPiM - DPiM, Drosophila Protein interaction Map • FBgn0002937 DroID - A comprehensive database of gene and protein interactions. • FBgn0002937 DRSC - Results from RNAi screens. • FBgn0002937 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0002937 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG9347-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0002937 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 41678 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 41678 modMine - Data generated by the modENCODE project. • FBgn0002937
Synonyms & Secondary IDs ( 9 )
Reported As
Symbol Synonym	anon-WO0148162.1 (von Lintig, 2001.7.5) anon-WO0148163.1 (von Lintig, 2001.7.5) CG9347 (Keleman et al., 2009.8.5, Ni et al., 2011.7.19) DRPE65 (Sagara, 2000.4.7) ninaB (Wang and Montell, 2005, Wang et al., 2007, Yang and O'Tousa, 2007, Peschel et al., 2006, Meyer et al., 2006, Krstic et al., 2009, Oberhauser et al., 2008, Halme et al., 2010, Curtis et al., 2007, Voolstra et al., 2010, Michaut et al., 2011, Japanese National Institute of Genetics, 2012.5.21, Nfonsam et al., 2012) RPE65 (Xu et al., 2004, ) β-diox (von Lintig et al., 2001, von Lintig, 2000.3.14, von Lintig and Vogt, 2000, )
Name Synonym	neither inactivation nor afterpotential B (Wang et al., 2007) β-carotene dioxygenase (von Lintig and Vogt, 2000)
Secondary FlyBase IDs
	FBgn0038171
References ( 45 )
Generate a list of	All references relating to this gene ( 45 )
List References by type	Research paper  ( 20 ) Supplementary material  ( 3 ) Review  ( 6 ) Personal communication to FlyBase  ( 5 ) Abstract  ( 3 ) FlyBase analysis  ( 1 ) DNA/RNA sequence record  ( 4 ) Stock list  ( 1 ) Website  ( 1 ) Patent  ( 1 )
Recent research papers ( 3 )
	Kim et al., 2012, Nat. Neurosci. 15(6): 876--883 Contribution of visual and circadian neural circuits to memory for prolonged mating induced by rivals. [FBrf0219349] Nfonsam et al., 2012, PLoS ONE 7(8): e44583 Analysis of the Transcriptomes Downstream of Eyeless and the Hedgehog, Decapentaplegic and Notch Signaling Pathways in Drosophila melanogaster. [FBrf0219414] Michaut et al., 2011, Dev. Growth Differ. 53(9): 982--993 Analyzing the function of a hox gene: An evolutionary approach. [FBrf0216990] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2011 Show reviews ...