A Database of Drosophila Genes & Genomes

FB2013_03, released May 7th, 2013
 

Gene Dmel\nos

General Information
SymbolDmel\nosSpeciesD. melanogaster
NamenanosAnnotation symbolCG5637
Feature typeprotein_coding_geneFlyBase IDFBgn0002962
Gene Model StatusCurrent Stock availability 18 publicly available
Also Known AsDRONANOS, NANOS, l(3)j3B6
Genomic Location
Chromosome (arm)3RRecombination map3-66.2
Cytogenetic map91F4-91F4Sequence location3R:14,982,960..14,985,924 [+]

Genomic Maps

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Automatically generated summary

See sections below for more information
The gene nanos is referred to in FlyBase by the symbol Dmel\nos (CG5637, FBgn0002962). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: protein binding. There is experimental evidence that it is involved in the biological process: germ-line stem cell maintenance; female meiosis chromosome segregation; dendrite morphogenesis; negative regulation of apoptotic process; segmentation; oogenesis; germ cell development; spermatogenesis. 284 alleles are reported. The phenotypes of these alleles are annotated with: multicellular structure; anatomical structure; organ system; abdominal segment; cytoplasmic part; cephalopharyngeal skeleton; organ system subdivision; extended germ band embryo; external compound sense organ; adult segment. It has 2 annotated transcripts and 2 annotated polypeptides. Protein features are: Nanos/Xcat2; Zinc finger, CCHC-type; Zinc finger, nanos-type. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of very low expression. Peak expression observed within 00-06 hour embryonic stages, in adult female stages. Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: adult ovary. Comments on Affy2 ProbeSet: ProbeSet 1632713_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of nos. Gene sequence location is 3R:14982960..14985924.

User Contributed Data
External Summaries

hide Phenotypic Description from the Red Book (Lindsley & Zimm 1992)
Gene/Allele symbols may differ from current usage
nos: nanos
Maternal-effect lethal. Mutant embryos lack abdominal segments, but have normal pole cells and pole plasm; no posterior activity in pole plasm. Transport or diffusion of the nos gene product from the posterior of the embryo seems to be essential for development of the wild-type abdominal pattern. Presence of the nos protein represses the activity of of the gene product encoded by the hb maternal transcript in the posterior half of the embryo (Hulskamp et al., 1989; Irish et al., 1989; Struhl, 1989). Eggs deficient for both hb and nos, when fertilized by hb+ sperm, develop into normal embryos and subsequently into viable flies.
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Description
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What does this section not display?
This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates Click here to see a list of all updates to this record from FB2010_08 and on.
hide Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map
Evidence for location
91F4-91F4  
Limits computationally determined from genome sequence between P{PZ}cdi07013&P{lacW}nosj3B6 and P{PZ}l(3)0334603346  
Experimentally Determined Cytological Location
Cytogenetic map
Notes
References
91F4-91F5  
(determined by in situ hybridisation)  
(Spradling et al., 1999)
91F13-91F13  
(determined by in situ hybridisation)  
(Wang and Lehmann, 1990)
70A1-70A2  
91E5--6  
(BDGP Project Members, 1994-1999)
91F13-91F13  
(determined by in situ hybridisation)  
(Wang and Lehmann, 1991)
91F-92A  
 
(Tearle and Nusslein-Volhard, 1987)
Experimentally Determined Recombination Data
Location
3-66.2
(Tearle and Nusslein-Volhard, 1987)
Left of (cM)
Right of (cM)
Notes
hide Gene Model & Products
Please see the GBrowse view of Dmel\nos for information on other features GBrowse View Help
To submit a correction to a gene model please use the Contact FlyBase form
detailed view FBtr0335020 FBtr0083750 FBtr0083732 FBtr0335019 FBtr0083749 FBtr0299958 FBtr0299957 FBpp0307026 FBpp0083164 FBpp0307025 FBpp0083146 FBpp0083163 FBpp0289235 FBpp0289234 FBti0025632 FBti0056222 FBti0113327 FBti0028972 FBti0007920 FBti0005580 FBti0004941 FBti0036183 FBti0036561 FBti0104990 FBti0033095 FBti0058910 FBti0108359 FBti0021124 FBti0043662 FBti0104886 FBti0126163_2 FBti0126163_1 FBti0100885 FBti0109857 FBti0099972 FBti0107146 FBti0040017 FBti0076921 FBti0111205 FBti0035924 FBti0139991 FBti0126164
Comments on Gene Model
Gene model reviewed during 5.47
hide Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Associated CDS (aa)
nos-RA
FBtr0083732
 NM_057310
  2349
  401
nos-RB
FBtr0335019
 NM_001275794
  2292
  382
Additional Transcript Data & Comments
Reported size (kB)
2.4 (northern blot)
(Wang and Lehmann, 1991)
Comments
External Data
Crossreferences
Rfam - RNA families database of alignments and covariance models
•
hide Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank protein
nos-PA  
FBpp0083146  
43.4  
401  
8.74  
  NP_476658
  AAF55641
nos-PB  
FBpp0307025  
41.5  
382  
8.56  
  NP_001262723
  AGB96103
Additional Polypeptide Data & Comments
Reported size (kDa)
401 (aa); 43 (kD predicted)
(Wang and Lehmann, 1991)
Comments
External Data
Linkouts
Crossreferences
InterPro domains - A database of protein families, domains, and functional sites
•
Nanos/Xcat2 (IPR008705)
Zinc finger, CCHC-type (IPR001878)
Zinc finger, nanos-type (IPR024161)
hide Sequences Consistent with the Gene Model
DDBJ /
EMBL /
GenBank
DNA sequence
Protein sequence
Name
AA978726
 
AE014297
AAF55641
 
AC006091
 
AF067873
 
AE014297
AGB96103
 
AQ034086
 
AW943146
 
AY075406
AAL68233
 
BI367670
 
BP544781
 
BT132708
 
CL705877
 
CO281261
 
CO291667
 
CO324230
 
CO328218
 
CZ467207
 
CZ467208
 
EC086455
 
EC200802
 
EC245157
 
EC256492
 
EV579242
 
EV579719
 
EV591523
 
G00548
 
GH753740
 
GH756775
 
GH757281
 
GH761383
 
GH773960
 
GH774219
 
GH776078
 
GH778522
 
GH793667
 
GH799769
 
GH811837
 
GH820710
 
GH821199
 
GH822879
 
GH823366
 
GH827678
 
GH829918
 
GH839542
 
GH840358
 
GH841422
 
GH843294
 
GH846453
 
GH848843
 
GH849199
 
GH858370
 
GH873831
 
GH881967
 
GH885840
 
GH887783
 
GH888577
 
GH895992
 
GH899171
 
GH901630
 
GH902398
 
GH906064
 
GH918663
 
GH918998
 
GH921636
 
GH923267
 
GH924598
 
GH928738
 
GH936754
 
M72421
AAA28715
 
 
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL
hide Mapped Features
Mapped Features have been reorganized, please see this article for details.
Additional mapped features and mutations can be found on GBrowse or related reports.
Type
Symbol & Location
Additional Notes
References
regulatory region
FBsf0000435201
3R:14,982,915..14,983,096
evidence=Reporter construct (in vivo)
(Ali et al., 2010, Halfon, 2012.6.19)
regulatory region
FBsf0000436581
3R:14,982,292..14,983,019
evidence=Reporter construct (in vivo)
(Ali et al., 2010, Halfon, 2012.6.19)
hide External Data
Linkouts
Crossreferences
hide Expression Data
hideTranscript Expression
No Assay Recorded
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage | early  
pole plasm  
(Barker et al., 1992)
organism | 0-10% egg length  
(Gavis and Lehmann, 1992)
Comment:0-2% egg length
distribution deduced from reporter
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage | female  
stage S4 oocyte & stage S5 oocyte & stage S6 oocyte  
• cell cortex
(Forrest and Gavis, 2003)
stage S8 oocyte | anterior & stage S9 oocyte | anterior  
(Forrest and Gavis, 2003)
stage S11 oocyte | posterior & stage S12 oocyte | posterior & stage S13 oocyte | posterior & stage S14 oocyte | posterior  
• cell cortex
(Forrest and Gavis, 2003)
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage  
organism | posterior  
(Bergsten and Gavis, 1999)
embryonic stage | early  
organism | anterior  
(Gavis and Lehmann, 1992)
embryonic stage 1 -- 2  
organism | posterior  
(Wang and Lehmann, 1991)
organism | 0-10% egg length  
(Polesello et al., 2002, Wang et al., 1994)
Comment:posterior pole
pole plasm  
(Wang et al., 1994)
embryonic stage 1 -- 3  
organism | posterior  
• germ plasm
(Robertson et al., 1999)
organism | posterior  
• perinuclear region of cytoplasm of germ cell nucleus
(Robertson et al., 1999)
embryonic stage 2  
organism | posterior  
(Bergsten and Gavis, 1999)
organism | 0-10% egg length  
(Bergsten and Gavis, 1999)
Comment:0-5% egg length
embryonic stage 3  
pole bud  
(Wang et al., 1994)
Comment:early stage 3
pole cell  
(Wang et al., 1994)
Comment:late stage 3
embryonic stage 4 -- 11  
pole cell  
(Wang et al., 1994)
oogenesis stage S5 -- S6  
nurse cell  
(Wang et al., 1994)
oocyte  
(Wang et al., 1994)
oogenesis stage S7 -- S8  
oocyte | anterior & restricted  
(Wang et al., 1994)
oogenesis stage S10A  
nurse cell  
(Wang et al., 1994)
oogenesis stage S11 -- S12  
oocyte  
(Wang et al., 1994)
oogenesis stage S13 -- S14  
oocyte | posterior  
(Wang et al., 1994)
northern blot
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 1 -- 12  
 
(Wang and Lehmann, 1991)
Comment:reference states 0-8 hr AEL
embryonic stage 3 -- 9  
pole cell  
(Wang and Lehmann, 1991)
oogenesis  
 
(Wang and Lehmann, 1991)
Additional Descriptive Data
in situ hybridization detects a localized nos transcript at the posterior pole in embryos, however, northern blot analysis detects high transcript levels in both anterior and posterior embryo halves, indicating that transcript is expressed uniformly, and subsequently localized to the posterior pole.
(Bergsten and Gavis, 1999)
As deduced from GFP labeled nos transcripts in early egg chambers nos transcript localizes to the posterior of the oocyte. There is a transient redistribution to an anterior ring at the margin of the oocyte during stages 8 and 9. nos transcript is no longer detected in the oocyte at stage 10. At stage 10b nurse cell dumping is initiated and by stage 11 nos transcript can be detected in the posterior cortex of the oocyte with a punctate distribution. Cooccurence with vas protein suggests that nos transcript associates with the germ plasm. Maximum accumulation of nos transcript is observed at stage 13/14.
(Forrest and Gavis, 2003)
In wild type and in pum mutant embryos, nos RNA is localized to the posterior pole plasm.
(Barker et al., 1992)
Wild type nos transcripts are expressed in a wild type pattern at the posterior pole in nosbcd.3UTR embryos. wild type nos transcripts are absent in nosbcd.3UTR embryos from osk1 females.
(Gavis and Lehmann, 1992)
The 2.4 kb nos transcript is detected at high levels in ovaries and in 0-2 hour embryos, and at much lower levels in 2-8 hour embryos. This transcript is not detected in older embryos, larvae, or pupae. The nos transcript localizes to the posterior pole of stage 1-2 embryos. The levels of nos transcript in pole cells are high at stage 3 and 4, and have declined dramatically by early germ band extension (stage 8), with no pole cell-specific staining detected after stage 10.
(Wang and Lehmann, 1991)
nos transcripts containing a bcd3'UTR are localized at the anterior end of embryos in a distributionresembling the wild type bcd pattern.
(Gavis and Lehmann, 1992)
During oogenesis, nos transcipt is first clearly detected at stage S5, in both nurse cells and oocytes. At stage S7-8, nos transcript transiently localizes to the anterior margin of the oocyte. At stage S10, a high level of nos transcript is present in oocytes; this transcript subsequently dumped into the oocyte. By stage S12, nos transcript begins to accumulate at the posterior pole of the oocyte, and is localized to the posterior pole of the oocyte at the later stages of oogenesis. In embryos, nos transcript is undetectable after germ band extension.
(Wang et al., 1994)
Marker for
Subcellular Localization
CV Term
hide Polypeptide Expression
No Assay Recorded
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage | early  
organism | gradient & posterior  
(Barker et al., 1992)
organism | gradient  
(Gavis and Lehmann, 1992)
immunolocalization
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 1  
organism | 0-10% egg length  
(Wang et al., 1994)
Comment:posterior pole
embryonic stage 2  
organism | 0-20% egg length  
(Gavis and Lehmann, 1994)
embryonic stage 3  
organism | 0-30% egg length & gradient  
(Wang et al., 1994)
Comment:early stage 3
pole cell  
(Wang et al., 1994)
Comment:late stage 3
embryonic stage 5  
pole cell  
(Matova and Cooley, 2001)
embryonic stage 6 -- 15  
germline stem cell  
(Matova and Cooley, 2001)
embryonic stage 12 -- 15  
germline cell  
(Wang et al., 1994)
third instar larval stage  
germline stem cell & cystoblast  
(Gilboa and Lehmann, 2004)
Comment:in primordial germ cell (PGC), at mid-third instar (ML3, 96hr AEL)
germline cyst  
(Gilboa and Lehmann, 2004)
adult stage | female  
germline stem cell & cystoblast  
(Gilboa and Lehmann, 2004)
germline cyst  
(Gilboa and Lehmann, 2004)
adult stage & oogenesis  
germline cyst of germarium region 2  
(Forbes and Lehmann, 1998)
female germline stem cell  
(Forbes and Lehmann, 1998)
cystoblast  
(Forbes and Lehmann, 1998)
oogenesis stage S1  
germarium region 1  
(Wang et al., 1994)
germarium region 2a  
(Wang et al., 1994)
oogenesis stage S3 -- S6  
nurse cell | faint  
(Wang et al., 1994)
oogenesis stage S10  
nurse cell | intense  
(Wang et al., 1994)
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 4 -- 11  
pole cell  
(Wang et al., 1994)
Additional Descriptive Data
During oogenesis, nos protein can be detected strongly in germarium region 1, and weakly in germarium region 2a. Low levels of nos protein can be observed in nurse cell/oocyte clusters at stages S3-6, and high levels in nurse cells at stage S10. nos protein is never observed in oocytes. After pole bud formation in embryos, nos protein is rapidly degraded outside of the pole cells. nos protein is observed in embryonic germline cells as late as embryonic stage 15.
(Wang et al., 1994)
Highest levels of nos protein in the germarium are detected in germline cysts in region 2. Levels decline as the cysts are encapsulated by somatic cells. Lower levels of nos protein have previously been observed in the germline stem cells and dividing cystoblasts (FBrf0074750).
(Forbes and Lehmann, 1998)
In wild type embryos, nos protein forms a concentration gradient emanating from the posterior pole and extending into the presumptive abdomen. nos protein distribution is indistinguishable in wild type and pum mutant embryos, as assayed by filtered fluorescence-imaging.
(Barker et al., 1992)
nos protein is expressed in opposing gradients emanating from the anterior and posterior poles of the embryo in nosbcd.3UTR embryos. In nosbcd.3UTR embryos from osk1 mothers, a single gradient of nos expression emanates from the anterior pole.
(Gavis and Lehmann, 1992)
Marker for
Subcellular Localization (GO Cellular Component)
CV term
Evidence
References
hide Expression Deduced from Reporters
Reporter: P{GAL4::VP16-nos.UTR}PBac{GreenEye.nosGAL4}
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage | mid  
germline cell  
(Van Doren et al., 1998)
embryonic stage | early  
pole cell  
(Van Doren et al., 1998)
embryonic stage 6  
organism | posterior  
(Van Doren et al., 1998)
embryonic stage 9  
germline cell  
(Van Doren et al., 1998)
embryonic stage 11 -- 15  
germline cell  
(Jenkins et al., 2003)
oogenesis  
female germline stem cell  
(Rorth, 1998)
Reporter: P{GAL4::VP16-nos.UTR}PBac{GreenEye.nosGAL4}
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage | mid  
germline cell  
(Van Doren et al., 1998)
embryonic stage | early  
pole cell  
(Van Doren et al., 1998)
embryonic stage 6  
organism | posterior  
(Van Doren et al., 1998)
embryonic stage 9  
germline cell  
(Van Doren et al., 1998)
embryonic stage 11 -- 15  
germline cell  
(Jenkins et al., 2003)
oogenesis  
female germline stem cell  
(Rorth, 1998)
hide High-Throughput Expression Data
Associated Tools
Reference
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
hide FlyAtlas Anatomy Microarray

FlyAtlas Anatomical Expression Data

(FlyAtlas-RNA.adult)

(FlyAtlas-RNA.larva)


   Styles
   Scales

Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: adult ovary.
[download data (TSV)]

Guide to FlyAtlas expression level colors
 
 No expression (0 - 9.999)
 
 Low expression (10 - 99.999)
 
 Moderate expression (100 - 499.999)
 
 High level expression (500 - 999.999)
 
 Very high expression (>999.999)

Linear, scaled to maximum expression level
Tissue   Expression Level
Larval Central Nervous System
 
 2.6
Larval Midgut
 
 8.8
Larval Hindgut
 
 4.6
Larval Malpighian Tubules
 
 5.2
Larval Fat Body
 
 16.5
Larval Salivary Gland
 
 2.3
Larval Trachea
 
 1.375
Larval Carcass
 
 1.375
Adult Head
 
 2
Adult Eye
 
 2.425
Adult Brain
 
 2.9
Adult Thoracic-Abdominal Ganglion
 
 4
Adult Crop
 
 4.6
Adult Midgut
 
 2
Adult Hindgut
 
 1.4
Adult Malpighian Tubules
 
 25.3
Adult Fat Body
 
 13.6
Adult Salivary Gland
 
 11.2
Adult Heart
 
 0.325
Adult VirginFemale Spermatheca
 
 18.2
Adult InseminatedFemale Spermatheca
 
 9.4
Adult Ovary
 
 2058.6
Adult Testis
 
 37.7
Adult Male Accessory Gland
 
 2.7
Adult Carcass
 
 32.9
Expression Level Scale
 None 
 Low 
 Moderate 
 High 
 Very high 
Linear, scaled to Moderate expression
Tissue   Expression Level
Larval Central Nervous System
 
 2.6
Larval Midgut
 
 8.8
Larval Hindgut
 
 4.6
Larval Malpighian Tubules
 
 5.2
Larval Fat Body
 
 16.5
Larval Salivary Gland
 
 2.3
Larval Trachea
 
 1.375
Larval Carcass
 
 1.375
Adult Head
 
 2
Adult Eye
 
 2.425
Adult Brain
 
 2.9
Adult Thoracic-Abdominal Ganglion
 
 4
Adult Crop
 
 4.6
Adult Midgut
 
 2
Adult Hindgut
 
 1.4
Adult Malpighian Tubules
 
 25.3
Adult Fat Body
 
 13.6
Adult Salivary Gland
 
 11.2
Adult Heart
 
 0.325
Adult VirginFemale Spermatheca
 
 18.2
Adult InseminatedFemale Spermatheca
 
 9.4
Adult Ovary
 (2058.6)
Adult Testis
 
 37.7
Adult Male Accessory Gland
 
 2.7
Adult Carcass
 
 32.9
Expression Level Scale
 None 
 Low 
 Moderate 
 High 
Linear, scaled to High level expression
Tissue   Expression Level
Larval Central Nervous System
 
 2.6
Larval Midgut
 
 8.8
Larval Hindgut
 
 4.6
Larval Malpighian Tubules
 
 5.2
Larval Fat Body
 
 16.5
Larval Salivary Gland
 
 2.3
Larval Trachea
 
 1.375
Larval Carcass
 
 1.375
Adult Head
 
 2
Adult Eye
 
 2.425
Adult Brain
 
 2.9
Adult Thoracic-Abdominal Ganglion
 
 4
Adult Crop
 
 4.6
Adult Midgut
 
 2
Adult Hindgut
 
 1.4
Adult Malpighian Tubules
 
 25.3
Adult Fat Body
 
 13.6
Adult Salivary Gland
 
 11.2
Adult Heart
 
 0.325
Adult VirginFemale Spermatheca
 
 18.2
Adult InseminatedFemale Spermatheca
 
 9.4
Adult Ovary
 (2058.6)
Adult Testis
 
 37.7
Adult Male Accessory Gland
 
 2.7
Adult Carcass
 
 32.9
Expression Level Scale
 None 
 Low 
 Moderate 
 High 
 Very high 
Linear, scaled to Very high expression
Tissue   Expression Level
Larval Central Nervous System
 
 2.6
Larval Midgut
 
 8.8
Larval Hindgut
 
 4.6
Larval Malpighian Tubules
 
 5.2
Larval Fat Body
 
 16.5
Larval Salivary Gland
 
 2.3
Larval Trachea
 
 1.375
Larval Carcass
 
 1.375
Adult Head
 
 2
Adult Eye
 
 2.425
Adult Brain
 
 2.9
Adult Thoracic-Abdominal Ganglion
 
 4
Adult Crop
 
 4.6
Adult Midgut
 
 2
Adult Hindgut
 
 1.4
Adult Malpighian Tubules
 
 25.3
Adult Fat Body
 
 13.6
Adult Salivary Gland
 
 11.2
Adult Heart
 
 0.325
Adult VirginFemale Spermatheca
 
 18.2
Adult InseminatedFemale Spermatheca
 
 9.4
Adult Ovary
 
 2058.6
Adult Testis
 
 37.7
Adult Male Accessory Gland
 
 2.7
Adult Carcass
 
 32.9
Expression Level Scale
 Very high 
log, scaled to maximum expression level
Tissue   Expression Level
Larval Central Nervous System
 
 2.6
Larval Midgut
 
 8.8
Larval Hindgut
 
 4.6
Larval Malpighian Tubules
 
 5.2
Larval Fat Body
 
 16.5
Larval Salivary Gland
 
 2.3
Larval Trachea
 
 1.375
Larval Carcass
 
 1.375
Adult Head
 
 2
Adult Eye
 
 2.425
Adult Brain
 
 2.9
Adult Thoracic-Abdominal Ganglion
 
 4
Adult Crop
 
 4.6
Adult Midgut
 
 2
Adult Hindgut
 
 1.4
Adult Malpighian Tubules
 
 25.3
Adult Fat Body
 
 13.6
Adult Salivary Gland
 
 11.2
Adult Heart
 
 0.325
Adult VirginFemale Spermatheca
 
 18.2
Adult InseminatedFemale Spermatheca
 
 9.4
Adult Ovary
 
 2058.6
Adult Testis
 
 37.7
Adult Male Accessory Gland
 
 2.7
Adult Carcass
 
 32.9
Expression Level Scale
 None 
 Low 
 Moderate 
 High 
 Very high 
log, scaled to Moderate expression
Tissue   Expression Level
Larval Central Nervous System
 
 2.6
Larval Midgut
 
 8.8
Larval Hindgut
 
 4.6
Larval Malpighian Tubules
 
 5.2
Larval Fat Body
 
 16.5
Larval Salivary Gland
 
 2.3
Larval Trachea
 
 1.375
Larval Carcass
 
 1.375
Adult Head
 
 2
Adult Eye
 
 2.425
Adult Brain
 
 2.9
Adult Thoracic-Abdominal Ganglion
 
 4
Adult Crop
 
 4.6
Adult Midgut
 
 2
Adult Hindgut
 
 1.4
Adult Malpighian Tubules
 
 25.3
Adult Fat Body
 
 13.6
Adult Salivary Gland
 
 11.2
Adult Heart
 
 0.325
Adult VirginFemale Spermatheca
 
 18.2
Adult InseminatedFemale Spermatheca
 
 9.4
Adult Ovary
 (2058.6)
Adult Testis
 
 37.7
Adult Male Accessory Gland
 
 2.7
Adult Carcass
 
 32.9
Expression Level Scale
 None 
 Low 
 Moderate 
 High 
log, scaled to High level expression
Tissue   Expression Level
Larval Central Nervous System
 
 2.6
Larval Midgut
 
 8.8
Larval Hindgut
 
 4.6
Larval Malpighian Tubules
 
 5.2
Larval Fat Body
 
 16.5
Larval Salivary Gland
 
 2.3
Larval Trachea
 
 1.375
Larval Carcass
 
 1.375
Adult Head
 
 2
Adult Eye
 
 2.425
Adult Brain
 
 2.9
Adult Thoracic-Abdominal Ganglion
 
 4
Adult Crop
 
 4.6
Adult Midgut
 
 2
Adult Hindgut
 
 1.4
Adult Malpighian Tubules
 
 25.3
Adult Fat Body
 
 13.6
Adult Salivary Gland
 
 11.2
Adult Heart
 
 0.325
Adult VirginFemale Spermatheca
 
 18.2
Adult InseminatedFemale Spermatheca
 
 9.4
Adult Ovary
 (2058.6)
Adult Testis
 
 37.7
Adult Male Accessory Gland
 
 2.7
Adult Carcass
 
 32.9
Expression Level Scale
 None 
 Low 
 Moderate 
 High 
 Very high 
log, scaled to Very high expression
Tissue   Expression Level
Larval Central Nervous System
 
 2.6
Larval Midgut
 
 8.8
Larval Hindgut
 
 4.6
Larval Malpighian Tubules
 
 5.2
Larval Fat Body
 
 16.5
Larval Salivary Gland
 
 2.3
Larval Trachea
 
 1.375
Larval Carcass
 
 1.375
Adult Head
 
 2
Adult Eye
 
 2.425
Adult Brain
 
 2.9
Adult Thoracic-Abdominal Ganglion
 
 4
Adult Crop
 
 4.6
Adult Midgut
 
 2
Adult Hindgut
 
 1.4
Adult Malpighian Tubules
 
 25.3
Adult Fat Body
 
 13.6
Adult Salivary Gland
 
 11.2
Adult Heart
 
 0.325
Adult VirginFemale Spermatheca
 
 18.2
Adult InseminatedFemale Spermatheca
 
 9.4
Adult Ovary
 
 2058.6
Adult Testis
 
 37.7
Adult Male Accessory Gland
 
 2.7
Adult Carcass
 
 32.9
Expression Level Scale
 None 
 Low 
 Moderate 
 High 
 Very high 
Heatmap
Tissue   Expression Level
Larval Central Nervous System
 
 
Larval Midgut
 
 
Larval Hindgut
 
 
Larval Malpighian Tubules
 
 
Larval Fat Body
 
 
Larval Salivary Gland
 
 
Larval Trachea
 
 
Larval Carcass
 
 
Adult Head
 
 
Adult Eye
 
 
Adult Brain
 
 
Adult Thoracic-Abdominal Ganglion
 
 
Adult Crop
 
 
Adult Midgut
 
 
Adult Hindgut
 
 
Adult Malpighian Tubules
 
 
Adult Fat Body
 
 
Adult Salivary Gland
 
 
Adult Heart
 
 
Adult VirginFemale Spermatheca
 
 
Adult InseminatedFemale Spermatheca
 
 
Adult Ovary
 
 
Adult Testis
 
 
Adult Male Accessory Gland
 
 
Adult Carcass
 
 

FlyAtlas Organ/Tissue Expression, larval vs. adult
Larval Expression Level Tissue Adult Expression Level
 
NA 		 Head
 
 2
 
NA 		 Eye
 
 2.425
 
NA 		 Brain
 
 2.9
 
2.6 		 Central Nervous System
 
 NA
 
NA 		 Thoracic-Abdominal Ganglion
 
 4
 
NA 		 Crop
 
 4.6
 
8.8 		 Midgut
 
 2
 
4.6 		 Hindgut
 
 1.4
 
5.2 		 Malpighian Tubules
 
 no informative data
 
no informative data 		 Fat Body
 
 no informative data
 
2.3 		 Salivary Gland
 
 no informative data
 
NA 		 Heart
 
 0.325
 
1.375 		 Trachea
 
 NA
 
NA 		 VirginFemale Spermatheca
 
 18.2
 
NA 		 InseminatedFemale Spermatheca
 
 9.4
 
NA 		 Ovary
 
 2058.6
 
NA 		 Testis
 
 37.7
 
NA 		 Male Accessory Gland
 
 2.7
 
1.375 		 Carcass
 
 no informative data

FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
hide modENCODE Anatomy RNA-Seq

modENCODE Tissue Expression Data

(modENCODE_mRNA-Seq_tissues)


   Styles
   Scales


[download data (TSV)]

Guide to modENCODE expression level colors
 
 No/Extremely low expression (0 - 0)
 
 Very low expression (1 - 3)
 
 Low expression (4 - 10)
 
 Moderate expression (11 - 25)
 
 Moderately high expression (26 - 50)
 
 High expression (51 - 100)
 
 Very high expression (101 - 1000)
 
 Extremely high expression (>1000)

Linear, scaled to maximum expression level
Tissue   Expression Level
imaginal disc, larvae L3 wandering
 
 1
central nervous system, larvae L3
 
 0
central nervous system, pupae P8
 
 0
head, virgin 1-day female
 
 0
head, virgin 4-day female
 
 0
head, virgin 20-day female
 
 0
head, mated 1-day female
 
 1
head, mated 4-day female
 
 0
head, mated 20-day female
 
 0
head, mated 1-day male
 
 0
head, mated 4-day male
 
 0
head, mated 20-day male
 
 0
salivary gland, larvae L3 wandering
 
 0
salivary gland, white prepupae
 
 0
digestive system, larvae L3 wandering
 
 0
digestive system, 1-day adult
 
 2
digestive system, 4-day adult
 
 4
digestive system, 20-day adult
 
 3
fat body, larvae L3 wandering
 
 0
fat body, white prepupae
 
 1
fat body, pupae P8
 
 1
carcass, larvae L3 wandering
 
 0
carcass, 1-day adult
 
 2
carcass, 4-day adult
 
 5
carcass, 20-day adult
 
 3
ovary, virgin 4-day female
 
 131
ovary, mated 4-day female
 
 86
testis, mated 4-day male
 
 2
accessory gland, mated 4-day male
 
 0
Expression Level Scale
 Very low 
 Low 
 Moderate 
 Moderately high 
 High 
 Very high 
Linear, scaled to Moderate expression
Tissue   Expression Level
imaginal disc, larvae L3 wandering
 
 1
central nervous system, larvae L3
 
 0
central nervous system, pupae P8
 
 0
head, virgin 1-day female
 
 0
head, virgin 4-day female
 
 0
head, virgin 20-day female
 
 0
head, mated 1-day female
 
 1
head, mated 4-day female
 
 0
head, mated 20-day female
 
 0
head, mated 1-day male
 
 0
head, mated 4-day male
 
 0
head, mated 20-day male
 
 0
salivary gland, larvae L3 wandering
 
 0
salivary gland, white prepupae
 
 0
digestive system, larvae L3 wandering
 
 0
digestive system, 1-day adult
 
 2
digestive system, 4-day adult
 
 4
digestive system, 20-day adult
 
 3
fat body, larvae L3 wandering
 
 0
fat body, white prepupae
 
 1
fat body, pupae P8
 
 1
carcass, larvae L3 wandering
 
 0
carcass, 1-day adult
 
 2
carcass, 4-day adult
 
 5
carcass, 20-day adult
 
 3
ovary, virgin 4-day female
 (131)
ovary, mated 4-day female
 (86)
testis, mated 4-day male
 
 2
accessory gland, mated 4-day male
 
 0
Expression Level Scale
 Very low 
 Low 
 Moderate 
 Moderately high 
Linear, scaled to High expression
Tissue   Expression Level
imaginal disc, larvae L3 wandering
 
 1
central nervous system, larvae L3
 
 0
central nervous system, pupae P8
 
 0
head, virgin 1-day female
 
 0
head, virgin 4-day female
 
 0
head, virgin 20-day female
 
 0
head, mated 1-day female
 
 1
head, mated 4-day female
 
 0
head, mated 20-day female
 
 0
head, mated 1-day male
 
 0
head, mated 4-day male
 
 0
head, mated 20-day male
 
 0
salivary gland, larvae L3 wandering
 
 0
salivary gland, white prepupae
 
 0
digestive system, larvae L3 wandering
 
 0
digestive system, 1-day adult
 
 2
digestive system, 4-day adult
 
 4
digestive system, 20-day adult
 
 3
fat body, larvae L3 wandering
 
 0
fat body, white prepupae
 
 1
fat body, pupae P8
 
 1
carcass, larvae L3 wandering
 
 0
carcass, 1-day adult
 
 2
carcass, 4-day adult
 
 5
carcass, 20-day adult
 
 3
ovary, virgin 4-day female
 (131)
ovary, mated 4-day female
 
 86
testis, mated 4-day male
 
 2
accessory gland, mated 4-day male
 
 0
Expression Level Scale
 Very low 
 Low 
 Moderate 
 Moderately high 
 High 
 Very high 
Linear, scaled to Extremely high expression
Tissue   Expression Level
imaginal disc, larvae L3 wandering
 
 1
central nervous system, larvae L3
 
 0
central nervous system, pupae P8
 
 0
head, virgin 1-day female
 
 0
head, virgin 4-day female
 
 0
head, virgin 20-day female
 
 0
head, mated 1-day female
 
 1
head, mated 4-day female
 
 0
head, mated 20-day female
 
 0
head, mated 1-day male
 
 0
head, mated 4-day male
 
 0
head, mated 20-day male
 
 0
salivary gland, larvae L3 wandering
 
 0
salivary gland, white prepupae
 
 0
digestive system, larvae L3 wandering
 
 0
digestive system, 1-day adult
 
 2
digestive system, 4-day adult
 
 4
digestive system, 20-day adult
 
 3
fat body, larvae L3 wandering
 
 0
fat body, white prepupae
 
 1
fat body, pupae P8
 
 1
carcass, larvae L3 wandering
 
 0
carcass, 1-day adult
 
 2
carcass, 4-day adult
 
 5
carcass, 20-day adult
 
 3
ovary, virgin 4-day female
 
 131
ovary, mated 4-day female
 
 86
testis, mated 4-day male
 
 2
accessory gland, mated 4-day male
 
 0
Expression Level Scale
 Extremely high 
log, scaled to maximum expression level
Tissue   Expression Level
imaginal disc, larvae L3 wandering
 
 1
central nervous system, larvae L3
 
 0
central nervous system, pupae P8
 
 0
head, virgin 1-day female
 
 0
head, virgin 4-day female
 
 0
head, virgin 20-day female
 
 0
head, mated 1-day female
 
 1
head, mated 4-day female
 
 0
head, mated 20-day female
 
 0
head, mated 1-day male
 
 0
head, mated 4-day male
 
 0
head, mated 20-day male
 
 0
salivary gland, larvae L3 wandering
 
 0
salivary gland, white prepupae
 
 0
digestive system, larvae L3 wandering
 
 0
digestive system, 1-day adult
 
 2
digestive system, 4-day adult
 
 4
digestive system, 20-day adult
 
 3
fat body, larvae L3 wandering
 
 0
fat body, white prepupae
 
 1
fat body, pupae P8
 
 1
carcass, larvae L3 wandering
 
 0
carcass, 1-day adult
 
 2
carcass, 4-day adult
 
 5
carcass, 20-day adult
 
 3
ovary, virgin 4-day female
 
 131
ovary, mated 4-day female
 
 86
testis, mated 4-day male
 
 2
accessory gland, mated 4-day male
 
 0
Expression Level Scale
 Very low 
 Low 
 Moderate 
 Moderately high 
 High 
 Very high 
log, scaled to Moderate expression
Tissue   Expression Level
imaginal disc, larvae L3 wandering
 
 1
central nervous system, larvae L3
 
 0
central nervous system, pupae P8
 
 0
head, virgin 1-day female
 
 0
head, virgin 4-day female
 
 0
head, virgin 20-day female
 
 0
head, mated 1-day female
 
 1
head, mated 4-day female
 
 0
head, mated 20-day female
 
 0
head, mated 1-day male
 
 0
head, mated 4-day male
 
 0
head, mated 20-day male
 
 0
salivary gland, larvae L3 wandering
 
 0
salivary gland, white prepupae
 
 0
digestive system, larvae L3 wandering
 
 0
digestive system, 1-day adult
 
 2
digestive system, 4-day adult
 
 4
digestive system, 20-day adult
 
 3
fat body, larvae L3 wandering
 
 0
fat body, white prepupae
 
 1
fat body, pupae P8
 
 1
carcass, larvae L3 wandering
 
 0
carcass, 1-day adult
 
 2
carcass, 4-day adult
 
 5
carcass, 20-day adult
 
 3
ovary, virgin 4-day female
 (131)
ovary, mated 4-day female
 (86)
testis, mated 4-day male
 
 2
accessory gland, mated 4-day male
 
 0
Expression Level Scale
 Very low 
 Low 
 Moderate 
 Moderately high 
log, scaled to High expression
Tissue   Expression Level
imaginal disc, larvae L3 wandering
 
 1
central nervous system, larvae L3
 
 0
central nervous system, pupae P8
 
 0
head, virgin 1-day female
 
 0
head, virgin 4-day female
 
 0
head, virgin 20-day female
 
 0
head, mated 1-day female
 
 1
head, mated 4-day female
 
 0
head, mated 20-day female
 
 0
head, mated 1-day male
 
 0
head, mated 4-day male
 
 0
head, mated 20-day male
 
 0
salivary gland, larvae L3 wandering
 
 0
salivary gland, white prepupae
 
 0
digestive system, larvae L3 wandering
 
 0
digestive system, 1-day adult
 
 2
digestive system, 4-day adult
 
 4
digestive system, 20-day adult
 
 3
fat body, larvae L3 wandering
 
 0
fat body, white prepupae
 
 1
fat body, pupae P8
 
 1
carcass, larvae L3 wandering
 
 0
carcass, 1-day adult
 
 2
carcass, 4-day adult
 
 5
carcass, 20-day adult
 
 3
ovary, virgin 4-day female
 131
ovary, mated 4-day female
 
 86
testis, mated 4-day male
 
 2
accessory gland, mated 4-day male
 
 0
Expression Level Scale
 Very low 
 Low 
 Moderate 
 Moderately high 
 High 
 Very high 
log, scaled to Extremely high expression
Tissue   Expression Level
imaginal disc, larvae L3 wandering
 
 1
central nervous system, larvae L3
 
 0
central nervous system, pupae P8
 
 0
head, virgin 1-day female
 
 0
head, virgin 4-day female
 
 0
head, virgin 20-day female
 
 0
head, mated 1-day female
 
 1
head, mated 4-day female
 
 0
head, mated 20-day female
 
 0
head, mated 1-day male
 
 0
head, mated 4-day male
 
 0
head, mated 20-day male
 
 0
salivary gland, larvae L3 wandering
 
 0
salivary gland, white prepupae
 
 0
digestive system, larvae L3 wandering
 
 0
digestive system, 1-day adult
 
 2
digestive system, 4-day adult
 
 4
digestive system, 20-day adult
 
 3
fat body, larvae L3 wandering
 
 0
fat body, white prepupae
 
 1
fat body, pupae P8
 
 1
carcass, larvae L3 wandering
 
 0
carcass, 1-day adult
 
 2
carcass, 4-day adult
 
 5
carcass, 20-day adult
 
 3
ovary, virgin 4-day female
 
 131
ovary, mated 4-day female
 
 86
testis, mated 4-day male
 
 2
accessory gland, mated 4-day male
 
 0
Expression Level Scale
 Very low 
 Low 
 Moderate 
 Moderately high 
 High 
 Very high 
 Extremely high 
Heatmap
Tissue   Expression Level
imaginal disc, larvae L3 wandering
 
 
central nervous system, larvae L3
 
 
central nervous system, pupae P8
 
 
head, virgin 1-day female
 
 
head, virgin 4-day female
 
 
head, virgin 20-day female
 
 
head, mated 1-day female
 
 
head, mated 4-day female
 
 
head, mated 20-day female
 
 
head, mated 1-day male
 
 
head, mated 4-day male
 
 
head, mated 20-day male
 
 
salivary gland, larvae L3 wandering
 
 
salivary gland, white prepupae
 
 
digestive system, larvae L3 wandering
 
 
digestive system, 1-day adult
 
 
digestive system, 4-day adult
 
 
digestive system, 20-day adult
 
 
fat body, larvae L3 wandering
 
 
fat body, white prepupae
 
 
fat body, pupae P8
 
 
carcass, larvae L3 wandering
 
 
carcass, 1-day adult
 
 
carcass, 4-day adult
 
 
carcass, 20-day adult
 
 
ovary, virgin 4-day female
 
 
ovary, mated 4-day female
 
 
testis, mated 4-day male
 
 
accessory gland, mated 4-day male
 
 

hide modENCODE Development RNA-Seq

modENCODE Temporal Expression Data

(modENCODE_mRNA-Seq_U)


   Styles
   Scales

Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of very low expression. Peak expression observed within 00-06 hour embryonic stages, in adult female stages.
[download data (TSV)]

Guide to modENCODE expression level colors
 
 No/Extremely low expression (0 - 0)
 
 Very low expression (1 - 3)
 
 Low expression (4 - 10)
 
 Moderate expression (11 - 25)
 
 Moderately high expression (26 - 50)
 
 High expression (51 - 100)
 
 Very high expression (101 - 1000)
 
 Extremely high expression (>1000)

Linear, scaled to maximum expression level
Developmental Stage   Expression Level
embryo 00-02hr
 
 243
embryo 02-04hr
 
 22
embryo 04-06hr
 
 8
embryo 06-08hr
 
 2
embryo 08-10hr
 
 3
embryo 10-12hr
 
 2
embryo 12-14hr
 
 1
embryo 14-16hr
 
 2
embryo 16-18hr
 
 1
embryo 18-20hr
 
 1
embryo 20-22hr
 
 1
embryo 22-24hr
 
 1
larva L1
 
 1
larva L2
 
 1
larva L3 12hr old
 
 1
larva L3 puffstage 1-2
 
 0
larva L3 puffstage 3-6
 
 0
larva L3 puffstage 7-9
 
 0
white prepupae new
 
 0
white prepupae 12hr
 
 1
white prepupae 24hr
 
 1
pupae 2d postWPP
 
 1
pupae 3d postWPP
 
 0
pupae 4d postWPP
 
 1
adult male 01day
 
 1
adult male 05day
 
 1
adult male 30day
 
 1
adult female 01day
 
 70
adult female 05day
 
 148
adult female 30day
 
 165
Expression Level Scale
 Very low 
 Low 
 Moderate 
 Moderately high 
 High 
 Very high 
Linear, scaled to Moderate expression
Developmental Stage   Expression Level
embryo 00-02hr
 (243)
embryo 02-04hr
 
 22
embryo 04-06hr
 
 8
embryo 06-08hr
 
 2
embryo 08-10hr
 
 3
embryo 10-12hr
 
 2
embryo 12-14hr
 
 1
embryo 14-16hr
 
 2
embryo 16-18hr
 
 1
embryo 18-20hr
 
 1
embryo 20-22hr
 
 1
embryo 22-24hr
 
 1
larva L1
 
 1
larva L2
 
 1
larva L3 12hr old
 
 1
larva L3 puffstage 1-2
 
 0
larva L3 puffstage 3-6
 
 0
larva L3 puffstage 7-9
 
 0
white prepupae new
 
 0
white prepupae 12hr
 
 1
white prepupae 24hr
 
 1
pupae 2d postWPP
 
 1
pupae 3d postWPP
 
 0
pupae 4d postWPP
 
 1
adult male 01day
 
 1
adult male 05day
 
 1
adult male 30day
 
 1
adult female 01day
 (70)
adult female 05day
 (148)
adult female 30day
 (165)
Expression Level Scale
 Very low 
 Low 
 Moderate 
 Moderately high 
Linear, scaled to High expression
Developmental Stage   Expression Level
embryo 00-02hr
 (243)
embryo 02-04hr
 
 22
embryo 04-06hr
 
 8
embryo 06-08hr
 
 2
embryo 08-10hr
 
 3
embryo 10-12hr
 
 2
embryo 12-14hr
 
 1
embryo 14-16hr
 
 2
embryo 16-18hr
 
 1
embryo 18-20hr
 
 1
embryo 20-22hr
 
 1
embryo 22-24hr
 
 1
larva L1
 
 1
larva L2
 
 1
larva L3 12hr old
 
 1
larva L3 puffstage 1-2
 
 0
larva L3 puffstage 3-6
 
 0
larva L3 puffstage 7-9
 
 0
white prepupae new
 
 0
white prepupae 12hr
 
 1
white prepupae 24hr
 
 1
pupae 2d postWPP
 
 1
pupae 3d postWPP
 
 0
pupae 4d postWPP
 
 1
adult male 01day
 
 1
adult male 05day
 
 1
adult male 30day
 
 1
adult female 01day
 
 70
adult female 05day
 (148)
adult female 30day
 (165)
Expression Level Scale
 Very low 
 Low 
 Moderate 
 Moderately high 
 High 
 Very high 
Linear, scaled to Extremely high expression
Developmental Stage   Expression Level
embryo 00-02hr
 
 243
embryo 02-04hr
 
 22
embryo 04-06hr
 
 8
embryo 06-08hr
 
 2
embryo 08-10hr
 
 3
embryo 10-12hr
 
 2
embryo 12-14hr
 
 1
embryo 14-16hr
 
 2
embryo 16-18hr
 
 1
embryo 18-20hr
 
 1
embryo 20-22hr
 
 1
embryo 22-24hr
 
 1
larva L1
 
 1
larva L2
 
 1
larva L3 12hr old
 
 1
larva L3 puffstage 1-2
 
 0
larva L3 puffstage 3-6
 
 0
larva L3 puffstage 7-9
 
 0
white prepupae new
 
 0
white prepupae 12hr
 
 1
white prepupae 24hr
 
 1
pupae 2d postWPP
 
 1
pupae 3d postWPP
 
 0
pupae 4d postWPP
 
 1
adult male 01day
 
 1
adult male 05day
 
 1
adult male 30day
 
 1
adult female 01day
 
 70
adult female 05day
 
 148
adult female 30day
 
 165
Expression Level Scale
 Extremely high 
log, scaled to maximum expression level
Developmental Stage   Expression Level
embryo 00-02hr
 
 243
embryo 02-04hr
 
 22
embryo 04-06hr
 
 8
embryo 06-08hr
 
 2
embryo 08-10hr
 
 3
embryo 10-12hr
 
 2
embryo 12-14hr
 
 1
embryo 14-16hr
 
 2
embryo 16-18hr
 
 1
embryo 18-20hr
 
 1
embryo 20-22hr
 
 1
embryo 22-24hr
 
 1
larva L1
 
 1
larva L2
 
 1
larva L3 12hr old
 
 1
larva L3 puffstage 1-2
 
 0
larva L3 puffstage 3-6
 
 0
larva L3 puffstage 7-9
 
 0
white prepupae new
 
 0
white prepupae 12hr
 
 1
white prepupae 24hr
 
 1
pupae 2d postWPP
 
 1
pupae 3d postWPP
 
 0
pupae 4d postWPP
 
 1
adult male 01day
 
 1
adult male 05day
 
 1
adult male 30day
 
 1
adult female 01day
 
 70
adult female 05day
 
 148
adult female 30day
 
 165
Expression Level Scale
 Very low 
 Low 
 Moderate 
 Moderately high 
 High 
 Very high 
log, scaled to Moderate expression
Developmental Stage   Expression Level
embryo 00-02hr
 (243)
embryo 02-04hr
 
 22
embryo 04-06hr
 
 8
embryo 06-08hr
 
 2
embryo 08-10hr
 
 3
embryo 10-12hr
 
 2
embryo 12-14hr
 
 1
embryo 14-16hr
 
 2
embryo 16-18hr
 
 1
embryo 18-20hr
 
 1
embryo 20-22hr
 
 1
embryo 22-24hr
 
 1
larva L1
 
 1
larva L2
 
 1
larva L3 12hr old
 
 1
larva L3 puffstage 1-2
 
 0
larva L3 puffstage 3-6
 
 0
larva L3 puffstage 7-9
 
 0
white prepupae new
 
 0
white prepupae 12hr
 
 1
white prepupae 24hr
 
 1
pupae 2d postWPP
 
 1
pupae 3d postWPP
 
 0
pupae 4d postWPP
 
 1
adult male 01day
 
 1
adult male 05day
 
 1
adult male 30day
 
 1
adult female 01day
 (70)
adult female 05day
 (148)
adult female 30day
 (165)
Expression Level Scale
 Very low 
 Low 
 Moderate 
 Moderately high 
log, scaled to High expression
Developmental Stage   Expression Level
embryo 00-02hr
 (243)
embryo 02-04hr
 
 22
embryo 04-06hr
 
 8
embryo 06-08hr
 
 2
embryo 08-10hr
 
 3
embryo 10-12hr
 
 2
embryo 12-14hr
 
 1
embryo 14-16hr
 
 2
embryo 16-18hr
 
 1
embryo 18-20hr
 
 1
embryo 20-22hr
 
 1
embryo 22-24hr
 
 1
larva L1
 
 1
larva L2
 
 1
larva L3 12hr old
 
 1
larva L3 puffstage 1-2
 
 0
larva L3 puffstage 3-6
 
 0
larva L3 puffstage 7-9
 
 0
white prepupae new
 
 0
white prepupae 12hr
 
 1
white prepupae 24hr
 
 1
pupae 2d postWPP
 
 1
pupae 3d postWPP
 
 0
pupae 4d postWPP
 
 1
adult male 01day
 
 1
adult male 05day
 
 1
adult male 30day
 
 1
adult female 01day
 
 70
adult female 05day
 (148)
adult female 30day
 (165)
Expression Level Scale
 Very low 
 Low 
 Moderate 
 Moderately high 
 High 
 Very high 
log, scaled to Extremely high expression
Developmental Stage   Expression Level
embryo 00-02hr
 
 243
embryo 02-04hr
 
 22
embryo 04-06hr
 
 8
embryo 06-08hr
 
 2
embryo 08-10hr
 
 3
embryo 10-12hr
 
 2
embryo 12-14hr
 
 1
embryo 14-16hr
 
 2
embryo 16-18hr
 
 1
embryo 18-20hr
 
 1
embryo 20-22hr
 
 1
embryo 22-24hr
 
 1
larva L1
 
 1
larva L2
 
 1
larva L3 12hr old
 
 1
larva L3 puffstage 1-2
 
 0
larva L3 puffstage 3-6
 
 0
larva L3 puffstage 7-9
 
 0
white prepupae new
 
 0
white prepupae 12hr
 
 1
white prepupae 24hr
 
 1
pupae 2d postWPP
 
 1
pupae 3d postWPP
 
 0
pupae 4d postWPP
 
 1
adult male 01day
 
 1
adult male 05day
 
 1
adult male 30day
 
 1
adult female 01day
 
 70
adult female 05day
 
 148
adult female 30day
 
 165
Expression Level Scale
 Very low 
 Low 
 Moderate 
 Moderately high 
 High 
 Very high 
 Extremely high 
Heatmap
Developmental Stage   Expression Level
embryo 00-02hr
 
 
embryo 02-04hr
 
 
embryo 04-06hr
 
 
embryo 06-08hr
 
 
embryo 08-10hr
 
 
embryo 10-12hr
 
 
embryo 12-14hr
 
 
embryo 14-16hr
 
 
embryo 16-18hr
 
 
embryo 18-20hr
 
 
embryo 20-22hr
 
 
embryo 22-24hr
 
 
larva L1
 
 
larva L2
 
 
larva L3 12hr old
 
 
larva L3 puffstage 1-2
 
 
larva L3 puffstage 3-6
 
 
larva L3 puffstage 7-9
 
 
white prepupae new
 
 
white prepupae 12hr
 
 
white prepupae 24hr
 
 
pupae 2d postWPP
 
 
pupae 3d postWPP
 
 
pupae 4d postWPP
 
 
adult male 01day
 
 
adult male 05day
 
 
adult male 30day
 
 
adult female 01day
 
 
adult female 05day
 
 
adult female 30day
 
 

modENCODE Temporal Expression Data (Graveley et al., 2011)
hide modENCODE Cell Lines RNA-Seq

modENCODE Cell Line Expression Data

(modENCODE_mRNA-Seq_cell.A)

(modENCODE_mRNA-Seq_cell.B)


   Styles
   Scales


[download data (TSV)]

Guide to modENCODE expression level colors
 
 No/Extremely low expression (0 - 0)
 
 Very low expression (1 - 3)
 
 Low expression (4 - 10)
 
 Moderate expression (11 - 25)
 
 Moderately high expression (26 - 50)
 
 High expression (51 - 100)
 
 Very high expression (101 - 1000)
 
 Extremely high expression (>1000)

Linear, scaled to maximum expression level
Cell Line   Expression Level
Schneider line 2 S2R+
 
 0
Schneider line 2 Sg4
 
 0
embryonic 1182-4H
 
 0
embryonic GM2
 
 0
embryonic Kc167
 
 4
embryonic S1
 
 0
embryonic S3
 
 0
leg disc CME L1
 
 0
wing disc CME-W2
 
 2
wing disc ML-DmD8
 
 0
wing disc ML-DmD9
 
 0
wing disc ML-DmD16-c3
 
 0
wing disc ML-DmD21
 
 0
wing disc ML-DmD32
 
 0
haltere disc ML-DmD17-c3
 
 0
eye-antennal disc ML-DmD11
 
 0
antennal disc ML-DmD20-c5
 
 0
mixed discs ML-DmD4-c1
 
 0
CNS ML-DmBG1-c1
 
 0
CNS ML-DmBG2-c2
 
 0
tumorous blood cells mbn2
 
 0
ovary fGS/OSS
 
 0
ovary OSC
 
 0
ovary OSS
 
 0
Expression Level Scale
 Very low 
 Low 
 Moderate 
Linear, scaled to Moderate expression
Cell Line   Expression Level
Schneider line 2 S2R+
 
 0
Schneider line 2 Sg4
 
 0
embryonic 1182-4H
 
 0
embryonic GM2
 
 0
embryonic Kc167
 
 4
embryonic S1
 
 0
embryonic S3
 
 0
leg disc CME L1
 
 0
wing disc CME-W2
 
 2
wing disc ML-DmD8
 
 0
wing disc ML-DmD9
 
 0
wing disc ML-DmD16-c3
 
 0
wing disc ML-DmD21
 
 0
wing disc ML-DmD32
 
 0
haltere disc ML-DmD17-c3
 
 0
eye-antennal disc ML-DmD11
 
 0
antennal disc ML-DmD20-c5
 
 0
mixed discs ML-DmD4-c1
 
 0
CNS ML-DmBG1-c1
 
 0
CNS ML-DmBG2-c2
 
 0
tumorous blood cells mbn2
 
 0
ovary fGS/OSS
 
 0
ovary OSC
 
 0
ovary OSS
 
 0
Expression Level Scale
 Very low 
 Low 
 Moderate 
 Moderately high 
Linear, scaled to High expression
Cell Line   Expression Level
Schneider line 2 S2R+
 
 0
Schneider line 2 Sg4
 
 0
embryonic 1182-4H
 
 0
embryonic GM2
 
 0
embryonic Kc167
 
 4
embryonic S1
 
 0
embryonic S3
 
 0
leg disc CME L1
 
 0
wing disc CME-W2
 
 2
wing disc ML-DmD8
 
 0
wing disc ML-DmD9
 
 0
wing disc ML-DmD16-c3
 
 0
wing disc ML-DmD21
 
 0
wing disc ML-DmD32
 
 0
haltere disc ML-DmD17-c3
 
 0
eye-antennal disc ML-DmD11
 
 0
antennal disc ML-DmD20-c5
 
 0
mixed discs ML-DmD4-c1
 
 0
CNS ML-DmBG1-c1
 
 0
CNS ML-DmBG2-c2
 
 0
tumorous blood cells mbn2
 
 0
ovary fGS/OSS
 
 0
ovary OSC
 
 0
ovary OSS
 
 0
Expression Level Scale
 Very low 
 Low 
 Moderate 
 Moderately high 
 High 
 Very high 
Linear, scaled to Extremely high expression
Cell Line   Expression Level
Schneider line 2 S2R+
 
 0
Schneider line 2 Sg4
 
 0
embryonic 1182-4H
 
 0
embryonic GM2
 
 0
embryonic Kc167
 
 4
embryonic S1
 
 0
embryonic S3
 
 0
leg disc CME L1
 
 0
wing disc CME-W2
 
 2
wing disc ML-DmD8
 
 0
wing disc ML-DmD9
 
 0
wing disc ML-DmD16-c3
 
 0
wing disc ML-DmD21
 
 0
wing disc ML-DmD32
 
 0
haltere disc ML-DmD17-c3
 
 0
eye-antennal disc ML-DmD11
 
 0
antennal disc ML-DmD20-c5
 
 0
mixed discs ML-DmD4-c1
 
 0
CNS ML-DmBG1-c1
 
 0
CNS ML-DmBG2-c2
 
 0
tumorous blood cells mbn2
 
 0
ovary fGS/OSS
 
 0
ovary OSC
 
 0
ovary OSS
 
 0
Expression Level Scale
 Extremely high 
log, scaled to maximum expression level
Cell Line   Expression Level
Schneider line 2 S2R+
 
 0
Schneider line 2 Sg4
 
 0
embryonic 1182-4H
 
 0
embryonic GM2
 
 0
embryonic Kc167
 
 4
embryonic S1
 
 0
embryonic S3
 
 0
leg disc CME L1
 
 0
wing disc CME-W2
 
 2
wing disc ML-DmD8
 
 0
wing disc ML-DmD9
 
 0
wing disc ML-DmD16-c3
 
 0
wing disc ML-DmD21
 
 0
wing disc ML-DmD32
 
 0
haltere disc ML-DmD17-c3
 
 0
eye-antennal disc ML-DmD11
 
 0
antennal disc ML-DmD20-c5
 
 0
mixed discs ML-DmD4-c1
 
 0
CNS ML-DmBG1-c1
 
 0
CNS ML-DmBG2-c2
 
 0
tumorous blood cells mbn2
 
 0
ovary fGS/OSS
 
 0
ovary OSC
 
 0
ovary OSS
 
 0
Expression Level Scale
 Very low 
 Low 
 Moderate 
log, scaled to Moderate expression
Cell Line   Expression Level
Schneider line 2 S2R+
 
 0
Schneider line 2 Sg4
 
 0
embryonic 1182-4H
 
 0
embryonic GM2
 
 0
embryonic Kc167
 
 4
embryonic S1
 
 0
embryonic S3
 
 0
leg disc CME L1
 
 0
wing disc CME-W2
 
 2
wing disc ML-DmD8
 
 0
wing disc ML-DmD9
 
 0
wing disc ML-DmD16-c3
 
 0
wing disc ML-DmD21
 
 0
wing disc ML-DmD32
 
 0
haltere disc ML-DmD17-c3
 
 0
eye-antennal disc ML-DmD11
 
 0
antennal disc ML-DmD20-c5
 
 0
mixed discs ML-DmD4-c1
 
 0
CNS ML-DmBG1-c1
 
 0
CNS ML-DmBG2-c2
 
 0
tumorous blood cells mbn2
 
 0
ovary fGS/OSS
 
 0
ovary OSC
 
 0
ovary OSS
 
 0
Expression Level Scale
 Very low 
 Low 
 Moderate 
 Moderately high 
log, scaled to High expression
Cell Line   Expression Level
Schneider line 2 S2R+
 
 0
Schneider line 2 Sg4
 
 0
embryonic 1182-4H
 
 0
embryonic GM2
 
 0
embryonic Kc167
 
 4
embryonic S1
 
 0
embryonic S3
 
 0
leg disc CME L1
 
 0
wing disc CME-W2
 
 2
wing disc ML-DmD8
 
 0
wing disc ML-DmD9
 
 0
wing disc ML-DmD16-c3
 
 0
wing disc ML-DmD21
 
 0
wing disc ML-DmD32
 
 0
haltere disc ML-DmD17-c3
 
 0
eye-antennal disc ML-DmD11
 
 0
antennal disc ML-DmD20-c5
 
 0
mixed discs ML-DmD4-c1
 
 0
CNS ML-DmBG1-c1
 
 0
CNS ML-DmBG2-c2
 
 0
tumorous blood cells mbn2
 
 0
ovary fGS/OSS
 
 0
ovary OSC
 
 0
ovary OSS
 
 0
Expression Level Scale
 Very low 
 Low 
 Moderate 
 Moderately high 
 High 
 Very high 
log, scaled to Extremely high expression
Cell Line   Expression Level
Schneider line 2 S2R+
 
 0
Schneider line 2 Sg4
 
 0
embryonic 1182-4H
 
 0
embryonic GM2
 
 0
embryonic Kc167
 
 4
embryonic S1
 
 0
embryonic S3
 
 0
leg disc CME L1
 
 0
wing disc CME-W2
 
 2
wing disc ML-DmD8
 
 0
wing disc ML-DmD9
 
 0
wing disc ML-DmD16-c3
 
 0
wing disc ML-DmD21
 
 0
wing disc ML-DmD32
 
 0
haltere disc ML-DmD17-c3
 
 0
eye-antennal disc ML-DmD11
 
 0
antennal disc ML-DmD20-c5
 
 0
mixed discs ML-DmD4-c1
 
 0
CNS ML-DmBG1-c1
 
 0
CNS ML-DmBG2-c2
 
 0
tumorous blood cells mbn2
 
 0
ovary fGS/OSS
 
 0
ovary OSC
 
 0
ovary OSS
 
 0
Expression Level Scale
 Very low 
 Low 
 Moderate 
 Moderately high 
 High 
 Very high 
 Extremely high 
Heatmap
Cell Line   Expression Level
Schneider line 2 S2R+
 
 
Schneider line 2 Sg4
 
 
embryonic 1182-4H
 
 
embryonic GM2
 
 
embryonic Kc167
 
 
embryonic S1
 
 
embryonic S3
 
 
leg disc CME L1
 
 
wing disc CME-W2
 
 
wing disc ML-DmD8
 
 
wing disc ML-DmD9
 
 
wing disc ML-DmD16-c3
 
 
wing disc ML-DmD21
 
 
wing disc ML-DmD32
 
 
haltere disc ML-DmD17-c3
 
 
eye-antennal disc ML-DmD11
 
 
antennal disc ML-DmD20-c5
 
 
mixed discs ML-DmD4-c1
 
 
CNS ML-DmBG1-c1
 
 
CNS ML-DmBG2-c2
 
 
tumorous blood cells mbn2
 
 
ovary fGS/OSS
 
 
ovary OSC
 
 
ovary OSS
 
 

hide modENCODE Treatments RNA-Seq

modENCODE Treatment Expression Data

(modENCODE_mRNA-Seq_treatments)


   Styles
   Scales


[download data (TSV)]

Guide to modENCODE expression level colors
 
 No/Extremely low expression (0 - 0)
 
 Very low expression (1 - 3)
 
 Low expression (4 - 10)
 
 Moderate expression (11 - 25)
 
 Moderately high expression (26 - 50)
 
 High expression (51 - 100)
 
 Very high expression (101 - 1000)
 
 Extremely high expression (>1000)

Linear, scaled to maximum expression level
Treatment   Expression Level
extended cold, 4-day adult
 
 14
cold shock, 4-day adult
 
 7
heat shock, 4-day adult
 
 44
Cadmium 50 mM 6 hrs, larvae L3
 
 0
Cadmium 50 mM 12 hrs, larvae L3
 
 0
Cadmium 50 mM 48 hrs, 4-day adult
 
 27
Cadmium 100 mM 48 hrs, 4-day adult
 
 79
Copper 0.5 mM 12 hrs, larvae L3
 
 0
Copper 15 mM 48 hrs, 4-day adult
 
 41
Zinc 5 mM 12 hrs, larvae L3
 
 0
Zinc 4.5 mM 48 hrs, 4-day adult
 
 9
Ethanol 2.5% 3 hrs, larvae L3
 
 106
Ethanol 5% 3 hrs, larvae L3
 
 0
Ethanol 10% 3 hrs, larvae L3
 
 0
Caffeine 1.5 mg/ml 4 hrs, larvae L3
 
 0
Caffeine 2.5 mg/ml 48 hrs, 4-day adult
 
 66
Caffeine 25 mg/ml 48 hrs, 4-day adult
 
 17
Paraquat 5 mM 48 hrs, 4-day adult
 
 55
Paraquat 10 mM 48 hrs, 4-day adult
 
 46
Rotenone 2 μg 12 hrs, larvae L3
 
 0
Rotenone 8 μg 12 hrs, larvae L3
 
 0
Expression Level Scale
 Very low 
 Low 
 Moderate 
 Moderately high 
 High 
 Very high 
Linear, scaled to Moderate expression
Treatment   Expression Level
extended cold, 4-day adult
 
 14
cold shock, 4-day adult
 
 7
heat shock, 4-day adult
 (44)
Cadmium 50 mM 6 hrs, larvae L3
 
 0
Cadmium 50 mM 12 hrs, larvae L3
 
 0
Cadmium 50 mM 48 hrs, 4-day adult
 (27)
Cadmium 100 mM 48 hrs, 4-day adult
 (79)
Copper 0.5 mM 12 hrs, larvae L3
 
 0
Copper 15 mM 48 hrs, 4-day adult
 (41)
Zinc 5 mM 12 hrs, larvae L3
 
 0
Zinc 4.5 mM 48 hrs, 4-day adult
 
 9
Ethanol 2.5% 3 hrs, larvae L3
 (106)
Ethanol 5% 3 hrs, larvae L3
 
 0
Ethanol 10% 3 hrs, larvae L3
 
 0
Caffeine 1.5 mg/ml 4 hrs, larvae L3
 
 0
Caffeine 2.5 mg/ml 48 hrs, 4-day adult
 (66)
Caffeine 25 mg/ml 48 hrs, 4-day adult
 
 17
Paraquat 5 mM 48 hrs, 4-day adult
 (55)
Paraquat 10 mM 48 hrs, 4-day adult
 (46)
Rotenone 2 μg 12 hrs, larvae L3
 
 0
Rotenone 8 μg 12 hrs, larvae L3
 
 0
Expression Level Scale
 Very low 
 Low 
 Moderate 
 Moderately high 
Linear, scaled to High expression
Treatment   Expression Level
extended cold, 4-day adult
 
 14
cold shock, 4-day adult
 
 7
heat shock, 4-day adult
 
 44
Cadmium 50 mM 6 hrs, larvae L3
 
 0
Cadmium 50 mM 12 hrs, larvae L3
 
 0
Cadmium 50 mM 48 hrs, 4-day adult
 
 27
Cadmium 100 mM 48 hrs, 4-day adult
 
 79
Copper 0.5 mM 12 hrs, larvae L3
 
 0
Copper 15 mM 48 hrs, 4-day adult
 
 41
Zinc 5 mM 12 hrs, larvae L3
 
 0
Zinc 4.5 mM 48 hrs, 4-day adult
 
 9
Ethanol 2.5% 3 hrs, larvae L3
 106
Ethanol 5% 3 hrs, larvae L3
 
 0
Ethanol 10% 3 hrs, larvae L3
 
 0
Caffeine 1.5 mg/ml 4 hrs, larvae L3
 
 0
Caffeine 2.5 mg/ml 48 hrs, 4-day adult
 
 66
Caffeine 25 mg/ml 48 hrs, 4-day adult
 
 17
Paraquat 5 mM 48 hrs, 4-day adult
 
 55
Paraquat 10 mM 48 hrs, 4-day adult
 
 46
Rotenone 2 μg 12 hrs, larvae L3
 
 0
Rotenone 8 μg 12 hrs, larvae L3
 
 0
Expression Level Scale
 Very low 
 Low 
 Moderate 
 Moderately high 
 High 
 Very high 
Linear, scaled to Extremely high expression
Treatment   Expression Level
extended cold, 4-day adult
 
 14
cold shock, 4-day adult
 
 7
heat shock, 4-day adult
 
 44
Cadmium 50 mM 6 hrs, larvae L3
 
 0
Cadmium 50 mM 12 hrs, larvae L3
 
 0
Cadmium 50 mM 48 hrs, 4-day adult
 
 27
Cadmium 100 mM 48 hrs, 4-day adult
 
 79
Copper 0.5 mM 12 hrs, larvae L3
 
 0
Copper 15 mM 48 hrs, 4-day adult
 
 41
Zinc 5 mM 12 hrs, larvae L3
 
 0
Zinc 4.5 mM 48 hrs, 4-day adult
 
 9
Ethanol 2.5% 3 hrs, larvae L3
 
 106
Ethanol 5% 3 hrs, larvae L3
 
 0
Ethanol 10% 3 hrs, larvae L3
 
 0
Caffeine 1.5 mg/ml 4 hrs, larvae L3
 
 0
Caffeine 2.5 mg/ml 48 hrs, 4-day adult
 
 66
Caffeine 25 mg/ml 48 hrs, 4-day adult
 
 17
Paraquat 5 mM 48 hrs, 4-day adult
 
 55
Paraquat 10 mM 48 hrs, 4-day adult
 
 46
Rotenone 2 μg 12 hrs, larvae L3
 
 0
Rotenone 8 μg 12 hrs, larvae L3
 
 0
Expression Level Scale
 Extremely high 
log, scaled to maximum expression level
Treatment   Expression Level
extended cold, 4-day adult
 
 14
cold shock, 4-day adult
 
 7
heat shock, 4-day adult
 
 44
Cadmium 50 mM 6 hrs, larvae L3
 
 0
Cadmium 50 mM 12 hrs, larvae L3
 
 0
Cadmium 50 mM 48 hrs, 4-day adult
 
 27
Cadmium 100 mM 48 hrs, 4-day adult
 
 79
Copper 0.5 mM 12 hrs, larvae L3
 
 0
Copper 15 mM 48 hrs, 4-day adult
 
 41
Zinc 5 mM 12 hrs, larvae L3
 
 0
Zinc 4.5 mM 48 hrs, 4-day adult
 
 9
Ethanol 2.5% 3 hrs, larvae L3
 
 106
Ethanol 5% 3 hrs, larvae L3
 
 0
Ethanol 10% 3 hrs, larvae L3
 
 0
Caffeine 1.5 mg/ml 4 hrs, larvae L3
 
 0
Caffeine 2.5 mg/ml 48 hrs, 4-day adult
 
 66
Caffeine 25 mg/ml 48 hrs, 4-day adult
 
 17
Paraquat 5 mM 48 hrs, 4-day adult
 
 55
Paraquat 10 mM 48 hrs, 4-day adult
 
 46
Rotenone 2 μg 12 hrs, larvae L3
 
 0
Rotenone 8 μg 12 hrs, larvae L3
 
 0
Expression Level Scale
 Very low 
 Low 
 Moderate 
 Moderately high 
 High 
 Very high 
log, scaled to Moderate expression
Treatment   Expression Level
extended cold, 4-day adult
 
 14
cold shock, 4-day adult
 
 7
heat shock, 4-day adult
 (44)
Cadmium 50 mM 6 hrs, larvae L3
 
 0
Cadmium 50 mM 12 hrs, larvae L3
 
 0
Cadmium 50 mM 48 hrs, 4-day adult
 27
Cadmium 100 mM 48 hrs, 4-day adult
 (79)
Copper 0.5 mM 12 hrs, larvae L3
 
 0
Copper 15 mM 48 hrs, 4-day adult
 (41)
Zinc 5 mM 12 hrs, larvae L3
 
 0
Zinc 4.5 mM 48 hrs, 4-day adult
 
 9
Ethanol 2.5% 3 hrs, larvae L3
 (106)
Ethanol 5% 3 hrs, larvae L3
 
 0
Ethanol 10% 3 hrs, larvae L3
 
 0
Caffeine 1.5 mg/ml 4 hrs, larvae L3
 
 0
Caffeine 2.5 mg/ml 48 hrs, 4-day adult
 (66)
Caffeine 25 mg/ml 48 hrs, 4-day adult
 
 17
Paraquat 5 mM 48 hrs, 4-day adult
 (55)
Paraquat 10 mM 48 hrs, 4-day adult
 (46)
Rotenone 2 μg 12 hrs, larvae L3
 
 0
Rotenone 8 μg 12 hrs, larvae L3
 
 0
Expression Level Scale
 Very low 
 Low 
 Moderate 
 Moderately high 
log, scaled to High expression
Treatment   Expression Level
extended cold, 4-day adult
 
 14
cold shock, 4-day adult
 
 7
heat shock, 4-day adult
 
 44
Cadmium 50 mM 6 hrs, larvae L3
 
 0
Cadmium 50 mM 12 hrs, larvae L3
 
 0
Cadmium 50 mM 48 hrs, 4-day adult
 
 27
Cadmium 100 mM 48 hrs, 4-day adult
 
 79
Copper 0.5 mM 12 hrs, larvae L3
 
 0
Copper 15 mM 48 hrs, 4-day adult
 
 41
Zinc 5 mM 12 hrs, larvae L3
 
 0
Zinc 4.5 mM 48 hrs, 4-day adult
 
 9
Ethanol 2.5% 3 hrs, larvae L3
 106
Ethanol 5% 3 hrs, larvae L3
 
 0
Ethanol 10% 3 hrs, larvae L3
 
 0
Caffeine 1.5 mg/ml 4 hrs, larvae L3
 
 0
Caffeine 2.5 mg/ml 48 hrs, 4-day adult
 
 66
Caffeine 25 mg/ml 48 hrs, 4-day adult
 
 17
Paraquat 5 mM 48 hrs, 4-day adult
 
 55
Paraquat 10 mM 48 hrs, 4-day adult
 
 46
Rotenone 2 μg 12 hrs, larvae L3
 
 0
Rotenone 8 μg 12 hrs, larvae L3
 
 0
Expression Level Scale
 Very low 
 Low 
 Moderate 
 Moderately high 
 High 
 Very high 
log, scaled to Extremely high expression
Treatment   Expression Level
extended cold, 4-day adult
 
 14
cold shock, 4-day adult
 
 7
heat shock, 4-day adult
 
 44
Cadmium 50 mM 6 hrs, larvae L3
 
 0
Cadmium 50 mM 12 hrs, larvae L3
 
 0
Cadmium 50 mM 48 hrs, 4-day adult
 
 27
Cadmium 100 mM 48 hrs, 4-day adult
 
 79
Copper 0.5 mM 12 hrs, larvae L3
 
 0
Copper 15 mM 48 hrs, 4-day adult
 
 41
Zinc 5 mM 12 hrs, larvae L3
 
 0
Zinc 4.5 mM 48 hrs, 4-day adult
 
 9
Ethanol 2.5% 3 hrs, larvae L3
 
 106
Ethanol 5% 3 hrs, larvae L3
 
 0
Ethanol 10% 3 hrs, larvae L3
 
 0
Caffeine 1.5 mg/ml 4 hrs, larvae L3
 
 0
Caffeine 2.5 mg/ml 48 hrs, 4-day adult
 
 66
Caffeine 25 mg/ml 48 hrs, 4-day adult
 
 17
Paraquat 5 mM 48 hrs, 4-day adult
 
 55
Paraquat 10 mM 48 hrs, 4-day adult
 
 46
Rotenone 2 μg 12 hrs, larvae L3
 
 0
Rotenone 8 μg 12 hrs, larvae L3
 
 0
Expression Level Scale
 Very low 
 Low 
 Moderate 
 Moderately high 
 High 
 Very high 
 Extremely high 
Heatmap
Treatment   Expression Level
extended cold, 4-day adult
 
 
cold shock, 4-day adult
 
 
heat shock, 4-day adult
 
 
Cadmium 50 mM 6 hrs, larvae L3
 
 
Cadmium 50 mM 12 hrs, larvae L3
 
 
Cadmium 50 mM 48 hrs, 4-day adult
 
 
Cadmium 100 mM 48 hrs, 4-day adult
 
 
Copper 0.5 mM 12 hrs, larvae L3
 
 
Copper 15 mM 48 hrs, 4-day adult
 
 
Zinc 5 mM 12 hrs, larvae L3
 
 
Zinc 4.5 mM 48 hrs, 4-day adult
 
 
Ethanol 2.5% 3 hrs, larvae L3
 
 
Ethanol 5% 3 hrs, larvae L3
 
 
Ethanol 10% 3 hrs, larvae L3
 
 
Caffeine 1.5 mg/ml 4 hrs, larvae L3
 
 
Caffeine 2.5 mg/ml 48 hrs, 4-day adult
 
 
Caffeine 25 mg/ml 48 hrs, 4-day adult
 
 
Paraquat 5 mM 48 hrs, 4-day adult
 
 
Paraquat 10 mM 48 hrs, 4-day adult
 
 
Rotenone 2 μg 12 hrs, larvae L3
 
 
Rotenone 8 μg 12 hrs, larvae L3
 
 

hide Expression Clusters
A cluster of genes with similar mRNA expression dynamics across development.
(The modENCODE Consortium, 2010, Graveley et al., 2011)
hide External Data & Images
Linkouts
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
•
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
•
hide Alleles & Phenotypes
hide Summary of Allele Phenotypes
Lethality
Allele
lethal, with Scer\GAL4h-1J3
lethal, with Scer\GAL4HD34A
lethal, with Scer\GAL4how-24B
lethal | dominant | embryonic stage | maternal effect
lethal | dominant | maternal effect
lethal | embryonic stage | maternal effect
lethal | maternal effect | recessive
lethal | partially
lethal | partially, with Scer\GAL4elav.PLu
lethal | pupal stage, with Scer\GAL4pnr-MD237
lethal | recessive
partially lethal - majority die, with Scer\GAL4h-1J3
partially lethal - majority die, with Scer\GAL4HD34A
partially lethal - majority die | embryonic stage | recessive
partially lethal - majority live | embryonic stage | maternal effect
viable
viable, with Scer\GAL47B
viable, with Scer\GAL4HD34A
Sterility
Allele
female fertile
female sterile
female sterile (with Df(3R)Dl-FX1)
female sterile (with Df(3R)nos)
female sterile | dominant
female sterile | recessive
fertile
Other Phenotypes
Allele
increased cell death | embryonic stage 12 | maternal effect
increased cell death | embryonic stage 13 | maternal effect
increased cell death | embryonic stage 14 | maternal effect
increased cell death | embryonic stage 15 | maternal effect
increased cell death | embryonic stage 16 | maternal effect
meiotic cell cycle defective | dominant
neuroanatomy defective, with Scer\GAL47B
neuroanatomy defective, with Scer\GAL48-123
neuroanatomy defective, with Scer\GAL4109(2)80
neuroanatomy defective, with Scer\GAL4477
neuroanatomy defective, with Scer\GAL4ey-OK107
neuroanatomy defective | late third instar larval stage (with Df(3R)Dl-X43)
neuroanatomy defective | late third instar larval stage (with nos18)
neuroanatomy defective | late third instar larval stage (with nos53)
neuroanatomy defective | somatic clone
neuroanatomy defective | third instar larval stage
visible
visible, with Scer\GAL4GMR.PF
visible, with Scer\GAL4hs.2sev
wild-type
Phenotype manifest in
Allele
abdomen
abdomen | ectopic
abdominal 1 ventral denticle belt | maternal effect
abdominal 2 ventral denticle belt | maternal effect
abdominal 3 ventral denticle belt | maternal effect
abdominal 4 ventral denticle belt | maternal effect
abdominal 5 ventral denticle belt | maternal effect
abdominal 6 ventral denticle belt | maternal effect
abdominal 7 ventral denticle belt | maternal effect
abdominal segment
abdominal segment, with nos+1+3.T:MS2\MCP.BS
abdominal segment, with nosBN
adult cuticle, with Scer\GAL4Eh.2.4
adult cuticle, with Scer\GAL4HD23A
adult cuticle, with Scer\GAL4HD44A
adult cuticle, with Scer\GAL4hs.2sev
adult cuticle, with Scer\GAL4KF42A
adult cuticle, with Scer\GAL4sca-109-68
cephalopharyngeal skeleton
cephalopharyngeal skeleton | embryonic stage | maternal effect
class IV dendritic arborizing neuron | late third instar larval stage (with Df(3R)Dl-X43)
class IV dendritic arborizing neuron | late third instar larval stage (with nos18)
class IV dendritic arborizing neuron | late third instar larval stage (with nos53)
class IV dendritic arborizing neuron | third instar larval stage
cystoblast & plasma membrane
cystocyte
cystocyte & plasma membrane
dendritic arborising neuron & dendrite | somatic clone
dendritic arborising neuron & dendritic tree, with Scer\GAL48-123
dendritic arborising neuron & dendritic tree, with Scer\GAL4109(2)80
dendritic arborising neuron & dendritic tree, with Scer\GAL4477
dorsal bridge
dorsal closure embryo
egg
egg chamber
egg chamber (with nos18)
egg chamber (with nos53)
embryo | anterior
embryo | ectopic | posterior
embryonic/first instar larval cuticle
embryonic abdominal segment
embryonic abdominal segment 1
embryonic abdominal segment 2
embryonic abdominal segment 3
embryonic abdominal segment 4
embryonic abdominal segment 5
embryonic abdominal segment 6
embryonic abdominal segment 7
embryonic abdominal segment 8
embryonic abdominal segment 9
embryonic abdominal segment 10
embryonic abdominal segment 11
embryonic abdominal segment, with nosBN
embryonic abdominal segment, with nosΔBX
embryonic epidermis
embryonic epidermis | maternal effect
embryonic head
embryonic head | maternal effect
embryonic thoracic segment
embryonic thoracic segment | maternal effect
embryonic thorax | anterior
extended germ band embryo
eye
female germline stem cell
female germline stem cell & plasma membrane
female germline stem cell | somatic clone
filzkorper | maternal effect
fusome
germarium
germarium (with Df(3R)Exel6183)
germarium | anterior
germline cell
germline cyst (with nos18)
germline cyst (with nos53)
germline cyst | ectopic (with Df(3R)Dl-FX3)
germline stem cell (with Df(3R)nos)
gonad | larval stage (with Df(3R)Dl-FX3)
Kenyon cell, with Scer\GAL47B
Kenyon cell, with Scer\GAL4ey-OK107
mesothoracic ventral denticle belt | maternal effect
metathoracic ventral denticle belt | maternal effect
mitochondrion
mushroom body & axon, with Scer\GAL47B
mushroom body & axon, with Scer\GAL4ey-OK107
ommatidium, with Scer\GAL4GMR.PF
ommatidium, with Scer\GAL4hs.2sev
ovariole
ovariole (with nos18)
ovariole (with nos53)
ovary
ovary (with Df(3R)nos)
pole cell
pole cell | embryonic stage 12 | maternal effect
pole cell | embryonic stage 13 | maternal effect
pole cell | embryonic stage 14 | maternal effect
pole cell | embryonic stage 15 | maternal effect
pole cell | embryonic stage 16 | maternal effect
pole cell | maternal effect
prothoracic ventral denticle belt | maternal effect
spectrosome
telson
testis
vertical bridge
wing, with Scer\GAL4Eh.2.4
wing, with Scer\GAL4HD23A
wing, with Scer\GAL4HD44A
wing, with Scer\GAL4hs.2sev
wing, with Scer\GAL4KF42A
wing, with Scer\GAL4sca-109-68
hide Classical Alleles ( 25 )
For All Classical Alleles Show

Allele of nosClassMutagenStocksKnown lesion
nosL7loss of function allele, hypomorphic allele - genetic evidence5 Yes
nosj3B62 --
nos01
1 Yes
nosc014941 --
nosCB-6897-3
1 --
nosEY013311 Yes
nosNP4727
1 --
nosNP5363
1 --
nosUY47411 Yes
nos18amorphic allele - genetic evidence, loss of function allele0 Yes
nos015360 --
nos056780 --
nos071170 --
nos17
0 Yes
nos53loss of function allele0 Yes
nosBNloss of function allele0 Yes
nosBNX2.1
0 Yes
nosEY00281
0 --
nosGS5240
0 Yes
nosj4B60 --
nosM820 --
nosNP4407
0 --
nosP510 --
nosScim0 Yes
nosunspecified
0 --
hide Alleles Carried on Transgenic Constructs ( 259 )
For All Alleles Carried on Transgenic Constructs Show

Allele of nosClassMutagenStocksKnown lesion
nosGD117151 Yes
nosHMS007851 Yes
nosHMS009301 Yes
nosJF029311 Yes
nos+1+3.T:MS2\MCP.BS0 Yes
nos+1.18.T:MS2\MCP.BS0 Yes
nos+2.18.T:MS2\MCP.BS0 Yes
nos+4.4.T:Ivir\HA10 Yes
nos+mSa0 Yes
nos+t5.70 Yes
nos108.T:Zzzz\FLAG0 Yes
nos108.αTub84B.UTR.T:Ivir\HA1wild-type allele0 Yes
nos111.αTub84B.UTR.T:Ivir\HA10 Yes
nos122.αTub84B.UTR.T:Ivir\HA10 Yes
nos139.αTub84B.UTR.T:Ivir\HA10 Yes
nos153.αTub84B.UTR.T:Ivir\HA10 Yes
nos154.αTub84B.UTR.T:Ivir\HA10 Yes
nos165.αTub84B.UTR.T:Ivir\HA10 Yes
nos18.T:MS2\MCP.BS0 Yes
nos18.αTub84B.UTR.T:Ivir\HA10 Yes
nos183.αTub84B.UTR.T:Ivir\HA10 Yes
nos19.αTub84B.UTR.T:Ivir\HA10 Yes
nos197.αTub84B.UTR.T:Ivir\HA10 Yes
nos204.αTub84B.UTR.T:Ivir\HA10 Yes
nos207.T:Zzzz\FLAG0 Yes
nos212.αTub84B.UTR.T:Ivir\HA10 Yes
nos21730 Yes
nos243.αTub84B.UTR.T:Ivir\HA10 Yes
nos246.αTub84B.UTR.T:Ivir\HA10 Yes
nos253.αTub84B.UTR.T:Ivir\HA10 Yes
nos254.αTub84B.UTR.T:Ivir\HA10 Yes
nos258.αTub84B.UTR.T:Ivir\HA10 Yes
nos263.αTub84B.UTR.T:Ivir\HA10 Yes
nos264.αTub84B.UTR.T:Ivir\HA10 Yes
nos272.αTub84B.UTR.T:Ivir\HA10 Yes
nos273.αTub84B.UTR.T:Ivir\HA10 Yes
nos277.αTub84B.UTR.T:Ivir\HA10 Yes
nos286.αTub84B.UTR.T:Ivir\HA10 Yes
nos295.αTub84B.UTR.T:Ivir\HA1wild-type allele0 Yes
nos3.αTub84B.UTR.T:Ivir\HA1wild-type allele0 Yes
nos3xSRE+0 Yes
nos3xSRE-0 Yes
nos4CF10 Yes
nos4CF20 Yes
nos504.T:Zzzz\FLAG0 Yes
nos505.αTub84B.UTR.T:Ivir\HA10 Yes
nos506.αTub84B.UTR.T:Ivir\HA10 Yes
nos512.αTub84B.UTR.T:Ivir\HA10 Yes
nos516.αTub84B.UTR.T:Ivir\HA10 Yes
nos517.αTub84B.UTR.T:Ivir\HA10 Yes
nos520.αTub84B.UTR.T:Ivir\HA10 Yes
nos524.αTub84B.UTR.T:Ivir\HA10 Yes
nos526.αTub84B.UTR.T:Ivir\HA10 Yes
nos538.αTub84B.UTR.T:Ivir\HA10 Yes
nos539.αTub84B.UTR.T:Ivir\HA10 Yes
nos549.αTub84B.UTR.T:Ivir\HA10 Yes
nos554.αTub84B.UTR.T:Ivir\HA10 Yes
nos558.αTub84B.UTR.T:Ivir\HA10 Yes
nos560.αTub84B.UTR.T:Ivir\HA10 Yes
nos565.αTub84B.UTR.T:Ivir\HA10 Yes
nos568.αTub84B.UTR.T:Ivir\HA10 Yes
nos579.αTub84B.UTR.T:Ivir\HA10 Yes
nos581.αTub84B.UTR.T:Ivir\HA10 Yes
nos585.αTub84B.UTR.T:Ivir\HA10 Yes
nos587.αTub84B.UTR.T:Ivir\HA10 Yes
nos592.αTub84B.UTR.T:Ivir\HA10 Yes
nos594.αTub84B.UTR.T:Ivir\HA10 Yes
nos595.αTub84B.UTR.T:Ivir\HA10 Yes
nos599.αTub84B.UTR.T:Ivir\HA10 Yes
nos6.T:MS2\MCP.BS0 Yes
nos6.αTub84B.UTR.T:Ivir\HA10 Yes
nos607.αTub84B.UTR.T:Ivir\HA10 Yes
nos614.αTub84B.UTR.T:Ivir\HA10 Yes
nos620.αTub84B.UTR.T:Ivir\HA10 Yes
nos623.αTub84B.UTR.T:Ivir\HA10 Yes
nos626.αTub84B.UTR.T:Ivir\HA10 Yes
nos627.αTub84B.UTR.T:Ivir\HA10 Yes
nos635.αTub84B.UTR.T:Ivir\HA10 Yes
nos641.αTub84B.UTR.T:Ivir\HA10 Yes
nos672.αTub84B.UTR.T:Ivir\HA10 Yes
nos75.T:Zzzz\FLAG0 Yes
nos805.T:Zzzz\FLAG0 Yes
nos85.T:Zzzz\FLAG0 Yes
nosALL.T:Hsap\MYC0 Yes
nosb.n.1-160 Yes
nosb.n.1-320 Yes
nosb.n.1-480 Yes
nosb.n.1-640 Yes
nosb.n.1-800 Yes
nosb.n.1-96.T:Ivir\HA10 Yes
nosb.n.1-960 Yes
nosb.n.21-80.A27U.T:Ivir\HA10 Yes
nosb.n.21-80.A37U.T:Ivir\HA10 Yes
nosb.n.21-80.C32G.T:Ivir\HA10 Yes
nosb.n.21-80.G28C.T:Ivir\HA10 Yes
nosb.n.21-80.G34C.T:Ivir\HA10 Yes
nosb.n.21-80.G38C.T:Ivir\HA10 Yes
nosb.n.21-80.T:Ivir\HA10 Yes
nosb.n.21-80.U41A.T:Ivir\HA10 Yes
nosb.n.21-80.U42C.T:Ivir\HA10 Yes
nosb.n.21-960 Yes
nosb.n.41-960 Yes
nosb.n.61-960 Yes
nosb.n.96-1.T:Ivir\HA10 Yes
nosb.n.96-10 Yes
nosb.n.T:Ivir\HA10 Yes
nosbam.3'UTR.T:Avic\GFP-EGFP0 --
nosbcd.3UTR.D0 Yes
nosbcd.3UTR0 Yes
nosbcd.nos.UTR0 Yes
nosbcdUTR.nos0 Yes
nosC.T:MS2\MCP0 Yes
nosC319Y,C354Y0 Yes
nosC319Y0 Yes
nosC354Y0 Yes
noscBa0 --
nosfl.cCa0 --
nosfs0 Yes
nosGMR.PW0 Yes
nosgnosb0 Yes
nosgnosGRH-0 Yes
nosgnosSREs-.GRH-0 Yes
nosgnosSREs-0 Yes
noshs.PW0 Yes
nosKK1056870 Yes
nosL7.cAa0 Yes
nosM.T:MS2\MCP0 Yes
nosN.T:MS2\MCP0 Yes
nosN50 Yes
nosnos.+1.+2'0 Yes
nosnos.+1.Hsp830 Yes
nosnos.+10.Hsp830 Yes
nosnos.+2'-2X.T:Ivir\HA10 Yes
nosnos.+2'-3X.T:Ivir\HA10 Yes
nosnos.+2'.Hsp830 Yes
nosnos.+2'A-3X.T:Ivir\HA10 Yes
nosnos.+2'B-3X.T:Ivir\HA10 Yes
nosnos.+2'C-3X.T:Ivir\HA10 Yes
nosnos.+2'D-3X.T:Ivir\HA10 Yes
nosnos.+2'E-3X.T:Ivir\HA10 Yes
nosnos.+2'F-3X.T:Ivir\HA10 Yes
nosnos.+2'ME-3X.T:Ivir\HA10 Yes
nosnos.+2(A)G:C0 Yes
nosnos.+2(D)G:C0 Yes
nosnos.+2,3.Hsp830 Yes
nosnos.+2-2X.T:Ivir\HA10 Yes
nosnos.+2-3X.T:Ivir\HA10 Yes
nosnos.+2.Hsp830 Yes
nosnos.+2.IIA:U+U51A0 Yes
nosnos.+2.IIA:U0 Yes
nosnos.+2.U51A0 Yes
nosnos.+2A.T:Ivir\HA10 Yes
nosnos.+2C.T:Ivir\HA10 Yes
nosnos.+2E.T:Ivir\HA10 Yes
nosnos.+2RO.T:Ivir\HA10 Yes
nosnos.+3-2X.T:Ivir\HA10 Yes
nosnos.+3-3X.T:Ivir\HA10 Yes
nosnos.+3.Hsp830 Yes
nosnos.+4-2X.T:Ivir\HA10 Yes
nosnos.+4-3X.T:Ivir\HA10 Yes
nosnos.+4.Hsp830 Yes
nosnos.+6.Hsp830 Yes
nosnos.+9.Hsp830 Yes
nosnos.IIA:U+U51A0 Yes
nososk.UTR0 Yes
nosRC.T:Hsap\MYC0 Yes
nosS3-.T:Hsap\MYC0 Yes
nosS5-.T:Hsap\MYC0 Yes
nosScer\UAS.T:Ivir\HA10 Yes
nosSI-.T:Hsap\MYC0 Yes
nosSRE1.SRE20 Yes
nosT:Avic\GFP-EGFP0 Yes
nosT:Hsap\MYC0 Yes
nosTCE+0 Yes
nosTCE.A15G0 Yes
nosTCE.bcdUTR0 Yes
nosTCE.G12U0 Yes
nosTCE.II^III.T:Ivir\HA10 Yes
nosTCE.IIIA.Tloop0 Yes
nosTCE.IIIA:U.Tloop0 Yes
nosTCE.IIIA:U0 Yes
nosTCE.IIIA:U^C720 Yes
nosTCE.IIIA0 Yes
nosTCE.IIIGC:GC0 Yes
nosTCE.IIIGC0 Yes
nosTCE.IIIU0 Yes
nosTCE.SRE-0 Yes
nosTCE.U18C0 Yes
nosTCE.ΔProxIII0 Yes
nosTCE10 Yes
nosTCE20 Yes
nosTCE30 Yes
nosTCE40 Yes
nosTCE50 Yes
nosTCE60 Yes
nosTCE70 Yes
nosTCE80 Yes
nosTCE90 Yes
nosTCEIIA.U0 Yes
nosTCEIIA0 Yes
nosTCEIII.TLoop0 Yes
nosTCEIII.U51A0 Yes
nosTCEIIU0 Yes
nosTCEIIUC.AG0 Yes
nostub3'UTR.Scer\UAS.T:Ivir\HA10 Yes
nosvir3'UTR0 Yes
nosWT.T:Hsap\MYC0 Yes
nosαTub84B.3'UTR.Brd.Scer\UAS0 Yes
nosαTub84B.3'UTR.nos+2.Scer\UAS0 Yes
nosαTub84B.3'UTR.nosB1m.TCEIIU.B3m1.Scer\UAS0 Yes
nosαTub84B.3'UTR.nosB3m1.Scer\UAS0 Yes
nosαTub84B.3'UTR.nosB3m2.Scer\UAS0 Yes
nosαTub84B.3'UTR.nosNR.Scer\UAS0 Yes
nosαTub84B.3'UTR.nosSRE.Scer\UAS0 Yes
nosαTub84B.3'UTR.nosTCE.Scer\UAS0 Yes
nosαTub84B.3'UTR.nosTCEIIA.IIIA.Scer\UAS0 Yes
nosαTub84B.3'UTR.nosTCEIIA.Scer\UAS0 Yes
nosαTub84B.3'UTR.nosTCEIIIA.Scer\UAS0 Yes
nosαTub84B.3'UTR.nosTCEIIU.B3m1.Scer\UAS0 Yes
nosαTub84B.3'UTR.nosTCEIIU.Scer\UAS0 Yes
nosαTub84B.3'UTR.pho.Scer\UAS0 Yes
nosαTub84B.3'UTR.Scer\UAS0 Yes
nosαTub84B.3'UTR.T:Avic\GFP-EGFP0 Yes
nosαTub84B.UTR.T:Ivir\HA10 Yes
nosαTub84B.UTR.virTCE.T:Ivir\HA10 Yes
nosΔ100 Yes
nosΔ2-2870 Yes
nosΔ2-3010 Yes
nosΔ2-3140 Yes
nosΔ218-2870 Yes
nosΔ288-3140 Yes
nosΔ33.T:Zzzz\FLAG0 Yes
nosΔ4.T:Zzzz\FLAG0 Yes
nosΔ5.T:Zzzz\FLAG0 Yes
nosΔ50-2180 Yes
nosΔA0 Yes
nosΔB.αTub84B.3'UTR.nos+2.Scer\UAS0 Yes
nosΔB.αTub84B.3'UTR.Scer\UAS0 Yes
nosΔB0 Yes
nosΔBE0 Yes
nosΔBX-tetra20 Yes
nosΔBX0 Yes
nosΔC0 Yes
nosΔD0 Yes
nosΔE0 Yes
nosΔEE0 Yes
nosΔEX0 Yes
nosΔF0 Yes
nosΔG0 Yes
nosΔLS.18.T:MS2\MCP.BS0 Yes
nosΔpi4120 Yes
nosΔpiroo-Δpi4120 Yes
nosΔpiroo0 Yes
nosΔTCE+HDE0 Yes
nosΔTCE-A0 Yes
nosΔTCE-B0 Yes
nosΔTCE.nos0 Yes
nosΔTCE0 Yes
nosΔX.αTub84B0 Yes
hide Aneuploid Aberrations
Disrupted in
(Wang and Lehmann, 1991)
(Spradling et al., 1999, BDGP Project Members, 1994-1999)
(Forbes and Lehmann, 1998, Bhat, 1999)
(Curtis et al., 1995)
(Ryder and Roote, 2004.11.10)
(Ryder, 2004.4.26)
(Li et al., 2009)
Not disrupted in
(Spradling et al., 1999, BDGP Project Members, 1994-1999)
(Wang and Lehmann, 1991)
(Wang and Lehmann, 1991)
hide Transgenic Constructs & Insertions
Transgenic Constructs
reporter construct
NameExpression Data
P{lacZ-nos3'UTR}No
P{lacZ-nos+2'}No
P{lacZ-nos+3}No
P{lacZ-nos+4}No
P{lacZ-nos+9}No
P{lacZ-nos+10}No
P{lacZ-nosΔ1}No
P{lacZ-nosΔ2}No
P{lacZ-nosΔ3}No
P{lacZ-nosΔ4}No
P{lacZ-nosΔ6}No
P{lacZ-nosΔ7}No
P{lacZ-nosΔ8}No
P{lacZ-nosΔ9}No
P{lacZ-nosΔ10}No
UAS construct
NameExpression Data
P{GD11715}NA
P{KK105687}NA
P{TRiP.HMS00785}NA
P{TRiP.HMS00930}NA
P{TRiP.JF02931}NA
P{UAS-HA-nos-tub3'UTR}NA
P{UAS-nos.HA}NA
P{UAS-nos-tub3'UTR}NA
P{UAS-nos-tub:B1m.TCEIIU.B3m1}NA
P{UAS-nos-tub:B3m1}NA
P{UAS-nos-tub:B3m2}NA
P{UAS-nos-tub:Brd}NA
P{UAS-nos-tub:nos+2}NA
P{UAS-nos-tub:NR}NA
P{UAS-nos-tub:pho}NA
P{UAS-nos-tub:SRE}NA
P{UAS-nos-tub:TCE}NA
P{UAS-nos-tub:TCEIIA.IIIA}NA
P{UAS-nos-tub:TCEIIA}NA
P{UAS-nos-tub:TCEIIU.B3m1}NA
P{UAS-nos-tub:TCEIIU}NA
P{UAS-nosΔB-tub3'UTR}NA
P{UAS-nosΔB-tub:nos+2}NA
GAL4 construct
NameExpression Data
P{GAL4::VP16-nos.UTR}No
P{GAL4-nos.NGT}No
P{GAL4-nos.UTR}No
P{nos-GAL4.U}No
P{nos-Gal4-GCN4.bcd3'UTR}No
PBac{GreenEye.nosGAL4}No
characterization construct
NameExpression Data
M{nos-int.B}NA
M{nos-int.NLS}NA
P{1-16}NA
P{1-32}NA
P{1-48}NA
P{1-64}NA
P{1-80}NA
P{1-96}NA
P{3xSRE+}NA
P{3xSRE-}NA
P{21-96}NA
P{41-96}NA
P{61-96}NA
P{96-1}NA
P{2173}NA
P{Dmnos}NA
P{GMR-nos.W}NA
P{gnosb}NA
P{gnosGRH-}NA
P{gnosSREs-}NA
P{gnosSREs-GRH-}NA
P{HA/1-96}NA
P{HA/21-80}NA
P{HA/96-1}NA
P{HA/A27U}NA
P{HA/A37U}NA
P{HA/C32G}NA
P{HA/G28C}NA
P{HA/G34C}NA
P{HA/G38C}NA
P{HA/U41A}NA
P{HA/U42C}NA
P{mel-vir3'UTR}NA
P{nos/bcd}NA
P{nos.3xFlag.75}NA
P{nos.3xFlag.85}NA
P{nos.3xFlag.108}NA
P{nos.3xFlag.207}NA
P{nos.3xFlag.504}NA
P{nos.3xFlag.805}NA
P{nos.3xFlag.Δ4}NA
P{nos.3xFlag.Δ5}NA
P{nos.3xFlag.Δ33}NA
P{nos-(ms2).6}NA
P{nos-(ms2).18}NA
P{nos(ΔBE)}NA
P{nos(ΔBX,tetra2)}NA
P{nos(ΔBX)}NA
P{nos(ΔEE)}NA
P{nos(ΔEX)}NA
P{nos(ΔTCE)}NA
P{nos(ΔTCE-A)}NA
P{nos(ΔTCE-B)}NA
P{nos(ΔX+αTub84B)}NA
P{nos}NA
P{nos+1-(ms2).18}NA
P{nos+1+3}NA
P{nos+2-(ms2).18}NA
P{nos3.αTub84B.UTR.T:Ivir\HA1}NA
P{nos6.αTub84B.UTR.T:Ivir\HA1}NA
P{nos19.αTub84B.UTR.T:Ivir\HA1}NA
P{nos108.αTub84B.UTR.T:Ivir\HA1}NA
P{nos111.αTub84B.UTR.T:Ivir\HA1}NA
P{nos122.αTub84B.UTR.T:Ivir\HA1}NA
P{nos139.αTub84B.UTR.T:Ivir\HA1}NA
P{nos153.αTub84B.UTR.T:Ivir\HA1}NA
P{nos154.αTub84B.UTR.T:Ivir\HA1}NA
P{nos165.αTub84B.UTR.T:Ivir\HA1}NA
P{nos183.αTub84B.UTR.T:Ivir\HA1}NA
P{nos197.αTub84B.UTR.T:Ivir\HA1}NA
P{nos204.αTub84B.UTR.T:Ivir\HA1}NA
P{nos212.αTub84B.UTR.T:Ivir\HA1}NA
P{nos243.αTub84B.UTR.T:Ivir\HA1}NA
P{nos246.αTub84B.UTR.T:Ivir\HA1}NA
P{nos253.αTub84B.UTR.T:Ivir\HA1}NA
P{nos254.αTub84B.UTR.T:Ivir\HA1}NA
P{nos258.αTub84B.UTR.T:Ivir\HA1}NA
P{nos263.αTub84B.UTR.T:Ivir\HA1}NA
P{nos264.αTub84B.UTR.T:Ivir\HA1}NA
P{nos272.αTub84B.UTR.T:Ivir\HA1}NA
P{nos273.αTub84B.UTR.T:Ivir\HA1}NA
P{nos277.αTub84B.UTR.T:Ivir\HA1}NA
P{nos286.αTub84B.UTR.T:Ivir\HA1}NA
P{nos295.αTub84B.UTR.T:Ivir\HA1}NA
P{nos505.αTub84B.UTR.T:Ivir\HA1}NA
P{nos506.αTub84B.UTR.T:Ivir\HA1}NA
P{nos512.αTub84B.UTR.T:Ivir\HA1}NA
P{nos516.αTub84B.UTR.T:Ivir\HA1}NA
P{nos517.αTub84B.UTR.T:Ivir\HA1}NA
P{nos520.αTub84B.UTR.T:Ivir\HA1}NA
P{nos524.αTub84B.UTR.T:Ivir\HA1}NA
P{nos526.αTub84B.UTR.T:Ivir\HA1}NA
P{nos538.αTub84B.UTR.T:Ivir\HA1}NA
P{nos539.αTub84B.UTR.T:Ivir\HA1}NA
P{nos549.αTub84B.UTR.T:Ivir\HA1}NA
P{nos554.αTub84B.UTR.T:Ivir\HA1}NA
P{nos558.αTub84B.UTR.T:Ivir\HA1}NA
P{nos560.αTub84B.UTR.T:Ivir\HA1}NA
P{nos565.αTub84B.UTR.T:Ivir\HA1}NA
P{nos568.αTub84B.UTR.T:Ivir\HA1}NA
P{nos579.αTub84B.UTR.T:Ivir\HA1}NA
P{nos581.αTub84B.UTR.T:Ivir\HA1}NA
P{nos585.αTub84B.UTR.T:Ivir\HA1}NA
P{nos587.αTub84B.UTR.T:Ivir\HA1}NA
P{nos592.αTub84B.UTR.T:Ivir\HA1}NA
P{nos594.αTub84B.UTR.T:Ivir\HA1}NA
P{nos595.αTub84B.UTR.T:Ivir\HA1}NA
P{nos599.αTub84B.UTR.T:Ivir\HA1}NA
P{nos607.αTub84B.UTR.T:Ivir\HA1}NA
P{nos614.αTub84B.UTR.T:Ivir\HA1}NA
P{nos620.αTub84B.UTR.T:Ivir\HA1}NA
P{nos623.αTub84B.UTR.T:Ivir\HA1}NA
P{nos626.αTub84B.UTR.T:Ivir\HA1}NA
P{nos627.αTub84B.UTR.T:Ivir\HA1}NA
P{nos635.αTub84B.UTR.T:Ivir\HA1}NA
P{nos641.αTub84B.UTR.T:Ivir\HA1}NA
P{nos672.αTub84B.UTR.T:Ivir\HA1}NA
P{nos+}NA
P{nosA18.αTub84B.UTR.T:Ivir\HA1}NA
P{nosbam.3'UTR.T:Avic\GFP-EGFP}NA
P{nosnos.+2-2X.T:Ivir\HA1}NA
P{nosnos.+2-3X.T:Ivir\HA1}NA
P{nosnos.+2'-2X.T:Ivir\HA1}NA
P{nosnos.+2'-3X.T:Ivir\HA1}NA
P{nosnos.+3-2X.T:Ivir\HA1}NA
P{nosnos.+3-3X.T:Ivir\HA1}NA
P{nosnos.+4-2X.T:Ivir\HA1}NA
P{nosnos.+4-3X.T:Ivir\HA1}NA
P{nosT:Avic\GFP-EGFP}NA
P{nosTCE.A15G}NA
P{nosTCE.G12U}NA
P{nosTCE.U18C}NA
P{nosTCE+}NA
P{nosΔA}NA
P{nosΔB}NA
P{nosΔC}NA
P{nosΔD}NA
P{nosΔE}NA
P{nosΔF}NA
P{nosΔG}NA
P{nosΔTCE.nos}NA
P{nosΔTCE+HDE}NA
P{nosαTub84B.3'UTR.T:Avic\GFP-EGFP}NA
P{nos-bam-GFP}NA
P{nos-bcd3'UTR}NA
P{nos-bcd/nos3'UTR}NA
P{nos-bcd}NA
P{nos-CP.C}NA
P{nos-CP.M}NA
P{nos-CP.N}NA
P{nos-cre}NA
P{nosHA/bcd}NA
P{nos-myc.ALL}NA
P{nos-myc.RC}NA
P{nos-myc.S3-}NA
P{nos-myc.S5-}NA
P{nos-myc.SI-}NA
P{nos-myc.V}NA
P{nos-myc.WT}NA
P{nos-osk3'UTR}NA
P{nos-phiC31\int.NLS}NA
P{nosSRE-}NA
P{nos-TCE-bcd}NA
P{nos-tub3'UTR.w}NA
P{nos-tub3'UTR}NA
P{nos-tub:nos+2.IIA/U}NA
P{nos-tub:nos+2.IIA/U+U51A}NA
P{nos-tub:nos+2.U51A}NA
P{nos-tub:nos+2'(A)-3X}NA
P{nos-tub:nos+2'(B)-3X}NA
P{nos-tub:nos+2'(C)-3X}NA
P{nos-tub:nos+2'(D)-3X}NA
P{nos-tub:nos+2'(E)-3X}NA
P{nos-tub:nos+2'(F)-3X}NA
P{nos-tub:nos+2'ME-3X}NA
P{nos-tub:nos+2(^)}NA
P{nos-tub:nos+2(A)}NA
P{nos-tub:nos+2(A)G:C}NA
P{nos-tub:nos+2(C)}NA
P{nos-tub:nos+2(D)G:C}NA
P{nos-tub:nos+2(E)}NA
P{nos-tub:nos+2(RO)}NA
P{nos-tub:nosIIA/U+U51A}NA
P{nos-tub:TCE.IIIA/U.Tloop}NA
P{nos-tub:TCE.IIIA/U^C72}NA
P{nos-tub:TCE.IIIA/U}NA
P{nos-tub:TCE.IIIA.Tloop}NA
P{nos-tub:TCE.IIIA}NA
P{nos-tub:TCE.IIIGC/GC}NA
P{nos-tub:TCE.IIIGC}NA
P{nos-tub:TCE.IIIU}NA
P{nos-tub:TCE.SRE-}NA
P{nos-tub:TCE.ΔProxIII}NA
P{nos-tub:TCEII^III}NA
P{nos-tub:TCEIIA/U}NA
P{nos-tub:TCEIIA}NA
P{nos-tub:TCEIII.TLoop}NA
P{nos-tub:TCEIII.U51A}NA
P{nos-tub:TCEIIU}NA
P{nos-tub:TCEIIUC:AG}NA
P{nos-tub:virTCE}NA
P{nosΔ10}NA
P{nos-Δ412}NA
P{nosΔLS-(ms2).18}NA
P{nos-Δpiroo}NA
P{nos-Δpiroo-Δpi412}NA
P{TCE1}NA
P{TCE2}NA
P{TCE3}NA
P{TCE4}NA
P{TCE5}NA
P{TCE6}NA
P{TCE7}NA
P{TCE8}NA
P{TCE9}NA
heat-shock construct
NameExpression Data
P{hs-nos.W}NA
P{nos-tub:nos+1}NA
P{nos-tub:nos+2,3}NA
P{nos-tub:nos+2'}NA
P{nos-tub:nos+2}NA
P{nos-tub:nos+3}NA
P{nos-tub:nos+4}NA
P{nos-tub:nos+6}NA
P{nos-tub:nos+9}NA
P{nos-tub:nos+10}NA
Insertions
Type of insertions
Name
Expression data
insertion of mobile activating element
P{EPgy2}CG11779EY01331
NA
P{EPgy2}nosEY00281
NA
P{GSV1}GSd302GSd302
NA
P{GSV2}CG11779GS5240
NA
P{Mae-UAS.6.11}nosUY4741
NA
miscellaneous insertions
P{5'SUPor-P}nosScim
NA
P{}nosBN
NA
P{RS3}nosCB-6897-3
NA
P{UAST-YFP.Rab40.H25N}CG1177901
NA
PBac{PB}nosc01494
NA
insertion of enhancer trap binary system
P{GawB}nosNP4407
No
P{GawB}nosNP4727
No
P{GawB}nosNP5363
No
insertion of enhancer trap
P{lacW}nosj3B6
No
P{lacW}nosj4B6
No
P{PZ}nos01536
No
P{PZ}nos05678
No
P{PZ}nos07117
No
hide Gene Ontology: Function, Process & Cellular Component ( 22 unique terms )
hide Terms Based on Experimental Evidence ( 9 terms )
Molecular Function
CV term
Evidence
References
protein binding
inferred from physical interaction with brat
(assigned by UniProtKB)
(Sonoda and Wharton, 2001)
inferred from physical interaction with cup
(Verrotti and Wharton, 2000)
Biological Process
CV term
Evidence
References
dendrite morphogenesis
inferred from mutant phenotype
(Ye et al., 2004, Brechbiel and Gavis, 2008)
female meiosis chromosome segregation
inferred from mutant phenotype
(Dobie et al., 2001)
germ cell development
inferred from mutant phenotype
(Wang and Lin, 2004)
germ-line stem cell maintenance
inferred from direct assay
(Li et al., 2009)
negative regulation of apoptotic process
inferred from genetic interaction with W
(Sato et al., 2007)
oogenesis
inferred from mutant phenotype
(Bhat, 1999)
segmentation
inferred from mutant phenotype
(Becalska et al., 2011)
spermatogenesis
inferred from mutant phenotype
(Bhat, 1999)
Cellular Component ( 0 terms)
hide Terms Based on Predictions or Assertions ( 14 terms )
Molecular Function
CV term
Evidence
References
RNA binding
inferred from electronic annotation with InterPro:IPR008705
(FlyBase Curators et al., 2004-)
zinc ion binding
inferred from electronic annotation with InterPro:IPR001878, InterPro:IPR008705
(FlyBase Curators et al., 2004-)
Biological Process
CV term
Evidence
References
anterior/posterior axis specification, embryo
non-traceable author statement
(Swiss-Prot Project Members, 1992.5.1)
traceable author statement
(Baek and Lee, 1999)
cell fate determination
traceable author statement
(Deng and Lin, 2001)
germ cell development
traceable author statement
(Deng and Lin, 2001)
germ cell migration
traceable author statement
(Wylie, 1999, Coffman, 2003)
germ-line cyst formation
non-traceable author statement
(Deng and Lin, 2001)
germ-line stem cell division
non-traceable author statement
(Mahowald, 2001)
mRNA polyadenylation
traceable author statement
(Johnstone and Lasko, 2001)
negative regulation of transcription, DNA-dependent
traceable author statement
(Leatherman and Jongens, 2003)
negative regulation of translation
non-traceable author statement
(Dean et al., 2002)
traceable author statement
(Deng and Lin, 2001, Johnstone and Lasko, 2001, Lall and Patel, 2001, Leatherman and Jongens, 2003)
oocyte anterior/posterior axis specification
non-traceable author statement
(Martin-Blanco, 2000)
pole cell migration
traceable author statement
(Leatherman and Jongens, 2003)
Cellular Component
CV term
Evidence
References
pole plasm
traceable author statement
(van Eeden and St. Johnston, 1999)
hide Sequence Ontology: Class of Gene
nuclear_gene
 
protein_coding_gene
 
hide Interactions & Pathways
hide Summary of Physical Interactions
protein-protein
Interacting group
Assay
References
nos - lost
pull down, peptide massfingerprinting
(Sinsimer et al., 2011)
nos - rump
nucleic acid uv cross-linking assay, autoradiography, pull down, peptide massfingerprinting, anti bait coimmunoprecipitation, primer specific pcr
(Sinsimer et al., 2011, Jain and Gavis, 2008)
hide Summary of Genetic Interactions
Interacts with
Please look at the allele data for full details of the genetic interactions
nos allele
Gene
References
nos18
cup
(Verrotti and Wharton, 2000)
dpp
(Gilboa and Lehmann, 2004)
tkv
(Gilboa and Lehmann, 2004)
nosbcd.3UTR
bcd
(Simpson-Brose et al., 1994)
hb
(Schulz and Tautz, 1994)
nosBN
Sxl
(Deshpande et al., 1999)
nosGMR.PW
pum
(Wharton et al., 1998)
nosL7
hb
(Arrizabalaga and Lehmann, 1999, Bajusz et al., 2001)
nosM82
osk
(Wilson et al., 1996)
nosN5
capu
(Wang and Lehmann, 1991)
osk
(Wang and Lehmann, 1991)
pum
(Wang and Lehmann, 1991)
spir
(Wang and Lehmann, 1991)
stau
(Wang and Lehmann, 1991)
tud
(Wang and Lehmann, 1991)
vas
(Wang and Lehmann, 1991)
vls
(Wang and Lehmann, 1991)
nosnos.+2'ME-3X.T:Ivir\HA1
vas
(Bergsten et al., 2001)
nosP51
osk
(Wilson et al., 1996)
nosSRE1.SRE2
osk
(Smibert et al., 1996)
nosunspecified
E(z)
(Pelegri and Lehmann, 1994)
pho
(Pelegri and Lehmann, 1994)
nosαTub84B.3'UTR.Scer\UAS
pum
(Ye et al., 2004)
nosαTub84B.UTR.T:Ivir\HA1
vas
(Crucs et al., 2000)
unspecified
stwl
(Maines et al., 2007)
hide External Data
Linkouts
BioGRID - A database of protein and genetic interactions
•
DroID - A comprehensive database of gene and protein interactions.
•
InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets.
•
hide Orthologs
hide OrthoDB Orthologs (45) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
OrthoDB orthology group searches
(Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288)
Drosophila inclusive ortholog search
EOG6M0FN1
Dipteran inclusive ortholog search
EOG6H72MN
Insect inclusive ortholog search
EOG6HHMZJ
Arthropod inclusive ortholog search
EOG644J2F
Metazoa inclusive ortholog search
EOG6ZSNZV
hideOrthologs in Drosophila Species (EOG6M0FN1)
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila melanogaster
fruit fly 
 
 
Drosophila simulans
 
Y
 
Drosophila sechellia
 
Y
 
Drosophila erecta
 
Y
 
Drosophila yakuba
 
 
 
Drosophila yakuba
 
Y
 
Drosophila ananassae
 
Y
 
Drosophila pseudoobscura pseudoobscura
 
 
 
Drosophila virilis
 
Y
 
Drosophila mojavensis
 
Y
 
Drosophila grimshawi
 
Y
 
hideOrthologs in non-Drosophila Dipterans (EOG6H72MN)
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Aedes aegypti
Yellow fever mosquito 
 
Anopheles gambiae
Malaria mosquito 
 
Culex quinquefasciatus
Southern house mosquito 
 
hideOrthologs in non-Dipteran Insects (EOG6HHMZJ)
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Apis mellifera
Western honey bee 
Amel\GB52596
 
Nasonia vitripennis
Parasitic wasp 
Nvit\nos
 
Acromyrmex echinatior
Panamanian leafcutter ant 
Aech\AECH13653
 
Atta cephalotes
Leafcutter ant 
Acep\ACEP23059
 
Camponotus floridanus
Florida carpenter ant 
Cflo\CFLO14286
 
Harpegnathos saltator
Jerdons jumping ant 
Hsal\HSAL14275
 
Linepithema humile
Argentine ant 
Lhum\LH25627
 
Pogonomyrmex barbatus
Red harvester ant 
Pbar\PB22443
 
Acyrthosiphon pisum
Pea aphid 
 
Acyrthosiphon pisum
Pea aphid 
 
Acyrthosiphon pisum
Pea aphid 
 
Bombyx mori
Silkmoth 
 
Bombyx mori
Silkmoth 
 
Orthologs in non-Insect Arthropods (None identified)
No non-Insect Arthropod orthologies identified
hideOrthologs in non-Arthropod Metazoa (EOG6ZSNZV)
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strongylocentrotus purpuratus
Purple sea urchin 
 
Strongylocentrotus purpuratus
Purple sea urchin 
 
Strongylocentrotus purpuratus
Purple sea urchin 
 
Strongylocentrotus purpuratus
Purple sea urchin 
 
Danio rerio
Zebrafish 
 
Danio rerio
Zebrafish 
 
Xenopus tropicalis
Western clawed frog 
 
Xenopus tropicalis
Western clawed frog 
 
Xenopus tropicalis
Western clawed frog 
 
Mus musculus
House mouse 
 
Mus musculus
House mouse 
 
Mus musculus
House mouse 
 
Rattus norvegicus
Norway rat 
 
Rattus norvegicus
Norway rat 
 
Rattus norvegicus
Norway rat 
 
Homo sapiens
Human 
 
Homo sapiens
Human 
 
Homo sapiens
Human 
 
hide Human Orthologs (3)
Gene
OMIM
HGNC
 
 
 
 
 
 
hideAAA Orthologs (9) based on analysis using Dmel annotation version 4.3
Organism
Gene
Drosophila simulans
Drosophila sechellia
Drosophila erecta
Drosophila yakuba
Drosophila ananassae
Drosophila willistoni
Drosophila virilis
Drosophila mojavensis
Drosophila grimshawi
hide Stocks & Reagents
hide Stocks Listed in FlyBase ( 18 )
Bloomington
32985
y1 sc* v1; P{TRiP.HMS00785}attP2
33973
y1 sc* v1; P{TRiP.HMS00930}attP2
7347
y1 w67c23; P{Mae-UAS.6.11}nosUY4741
28300
y1 v1; P{TRiP.JF02931}attP2/TM3, Sb1
3285
st1 nosL7 e1/TM3, Sb1 Ser1
20114
y1 w67c23; P{EPgy2}CG11779EY01331 nosEY01331
Harvard
-
PBac{PB}nosc01494
Kyoto
106942
st1 pum13 nosL7 e1
106957
st1 nosL7 e1/TM3, Sb1
124257
w1118; P{RS3}nosCB-6897-3 / TM6C, Sb1
113697
w*; P{GawB}nosNP5363 / TM6, P{UAS-lacZ.UW23-1}UW23-1
VDRC
v22693
w1118; P{GD11715}v22693
hide Genomic Clones ( 2 )

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
hide cDNA Clones ( 56 )

Please Note
This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones
Other clones
hide RNAi & Array Information
Linkouts
DRSC - Results from RNAi screens.
•
GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents
•
hide Antibody Information
polyclonal
(Xia et al., 2012, Gilboa and Lehmann, 2004, Wang et al., 1994)
hide Other Information
hide Discoverer
Lehmann.
 
hide Etymology
hide Identification
hide Relationship to Other Genes
Source for database identity of
Source for database merge of
Source for merge of: nos l(3)j3B6
(Spradling et al., 1999)
Additional comments
hide Other Comments
smg protein interacts with AGO1 protein, and AGO1 protein interacts with and is required for the translational repression of the smg target, nos mRNA. The AGO1 protein/nos mRNA interaction does not require a miRNA, but does require msg protein.
(Pinder and Smibert, 2013)
The repression of nos protein expression seen in the daughter cells of the germline stem cells in the female germarium is dependent on the presence of Sxl protein binding site in the nos 3' UTR.
(Chau et al., 2012)
Regulation of nos protein expression in wild-type germaria depends on sequences in the 3'UTR of the transcript.
(Li et al., 2009)
nos is not required for the initial elaboration of dendritic branches in class IV da neurons, but is required at later stages of development to maintain dendrite complexity.
(Brechbiel and Gavis, 2008)
nos mRNA localisation is dispensible for normal abdominal patterning in the embryo, providing that nos translation is properly modulated. In contrast, localisation of nos mRNA to the germ plasm, but not translational regulation, is essential for nos function in the developing germ cells.
(Gavis et al., 2008)
nos is essential for establishing and maintaining germline stem cells by preventing their precocious entry into oogenesis. nos is required cell autonomously for germline stem cell renewal (though not cyst differentiation). It is likely that nos represses the translation of differentiation factors in primoridal germ cells and germline stem cells. Zygotic nos is required at two distinct phases during pre-oogenic PGC development. The first pase is embryonic to first larval instar. The second phase is from the late third-instar to the pupal stage, that spans germline stenm cell establishment.
(Wang and Lin, 2004)
nos and pum control the elaboration of high-order dendritic branches of class III and IV, but not class I and II, dendritic arborization neurons. nos and pum require each other to control dendrite morphogenesis, but hb is not required.
(Ye et al., 2004)
Posterior localization of nos RNA initiates immediately upon nurse cell dumping and occurs by diffusion, entrapment and actin-dependent anchoring of RNA entering the oocyte. Long range movement of nos RNA can occur in the absence of oocyte streaming.
(Forrest and Gavis, 2003)
The CCHC zinc finger motifs of nos, which coordinate two metal ions, are essential for all known functions of the nos protein. The "tail region" C-terminal to the zinc fingers is required for abdomen formation and germ cell migration, but not for oogenesis.
(Arrizabalaga and Lehmann, 1999)
The joint action of two RNA degradation pathways (a maternally encoded and a zygotic pathway) controls maternal transcript degradation and its timing in the early embryo. nos transcripts (relatively rare in abundance) are degraded almost exclusively by the maternal pathway.
(Bashirullah et al., 1999)
Localisation of nos RNA by components of the posteriorly localised germ plasm activates its translation by preventing interaction of nos RNA with translational repressors.
(Bergsten and Gavis, 1999)
In the female germ line nos is required for the functioning of stem cells. In the male germline, nos is required for the maintenance of stem cells.
(Bhat, 1999)
In mutant females, germline stem cells divide only a few times and then degenerate, due to loss of plasma membrane. Following germ cell loss, germaria carry on massive mitochondrial biogenesis activity. In mutant males, spermatogenesis is progressively affected and the males eventually become sterile.
(Bhat, 1999)
The developmental defects of nos- pole cells can be traced to the blastoderm stage. nos- pole cells, but not nos+ pole cells, are transcriptionally active in the blastoderm. The nos- pole cells also abnormally continue dividing, instead of becoming quiescent. Sxl is an important target for repression by nos in germ cells.
(Deshpande et al., 1999)
The nos gene product forms a ternary complex with the RNA-binding domain of pum and the hb NRE (nos response element).
(Sonoda and Wharton, 1999)
Maternally deposited nos is essential for normal germ cell migration. Lack of zygotic activity of nos and pum has a dramatic effect on germline development of homozygous females. nos and pum act in the germline, affecting germline stem cell development. nos function lies in the differentiation of the stem cell progeny, the cystoblast. nos and pum may interact with different partners in the germline.
(Forbes and Lehmann, 1998)
Germ cells of embryos deriving from nos females do not show premature enhancer trap line gene expression, contrary to previous reports (FBrf0087514).
(Heller and Steinmann-Zwicky, 1998)
In a sample of 79 genes with multiple introns, 33 showed significant heterogeneity in G+C content among introns of the same gene and significant positive correspondence between the intron and the third codon position G+C content within genes. These results are consistent with selection adding against preferred codons at the start of genes.
(Kliman and Eyre-Walker, 1998)
A Cys-Cys-His-Cys metal-binding domain in nos is essential for translational regulation. Each of two CCHC motifs are essential for nos activity. Each is capable of binding Zn(II) or Co(II) ions. nos binds to RNA with high affinity but cannot alone discriminate between mutant and wild-type NRE RNAs.
(Curtis et al., 1997)
A study of the mechanisms of nos-mediated translational repression indicates that nos and pum determine posterior morphology by promoting the deadenylation of maternal hb mRNA, thereby repressing its translation.
(Wreden et al., 1997)
The nos protein gradient in embryos is generated by translational regulation acting through the 184bp TCE (Translational Control Element) of the 3' UTR. The TCE is required to prevent the translation of unlocalized nos mRNA.
(Dahanukar and Wharton, 1996)
Cis-acting sequences within the nos 3'UTR, both necessary and sufficient for localisation of RNA to the posterior of the embryo, occupy a 547 nucleotide region and contain sequences that are partially redundant in function.
(Gavis et al., 1996)
A 90 nucleotide region of the nos 3'UTR is identified that mediated translational repression of unlocalised nos RNA, this region is designated as the nos translational control element (TCE).
(Gavis et al., 1996)
nos is essential for germline formation, pole cells lacking nos activity fail to migrate into the gonads so do not become functional germ cells. In such pole cells, gene expression begins prematurely during pole cell migration. Premature activation of genes in these germline precursors may mean that these cells fail to develop normally.
(Kobayashi et al., 1996)
smg protein represses translation of unlocalized nos mRNA in the embryo. Two SREs (smg Response elements) map to the nos 3' UTR.
(Smibert et al., 1996)
nos is a conserved organiser of anterior-posterior patterning in the Diptera.
(Curtis et al., 1995)
Posterior localisation of the nos RNA is mediated by sequences within the 3' untranslated region and requires the function of eight posterior group genes. Unlocalised nos RNA is translationally repressed, this repression is mediated by the 3' untranslated region. Sequences that mediate translational repression overlap but are independent of those required for localisation.
(Gavis and Lehmann, 1995)
Variation of a microsatellite within the nos locus has been studied in North American populations of D.melanogaster.
(Goldstein and Clark, 1995)
nos response elements (NRE) in the hb mRNA mediate nos repression of hb maternal transcript translation. pum protein is an NRE binding factor, pum recognises the NRE and recruits nos, the resulting complex is thought to inhibit some component of the translation machinery.
(Murata and Wharton, 1995)
A small part of the nos 3'UTR, called NTE1, inhibits translation of the nos product. Additional sequences in the 3'UTR are required for posterior group gene-dependent activation of nos translation.
(Smibert et al., 1995)
The nos gene product primarily recognises nanos response element (NRE) bound proteins, the pum gene product, and this complex interferes with translation of hb mRNA.
(Wharton et al., 1995)
Posterior localisation of nos RNA is mediated by sequences within the nos 3' untranslated region (3'UTR) and required the function of eight genes of the posterior group. Unlocalised nos RNA in embryos mutant for any of the posterior genes is stable and the embryos develop abdominal defects characteristic of nos mutants. Unlocalised nos RNA is translationally repressed, repression is mediated by the 3' UTR and can be alleviated by replacement of the UTR with heterologous UTR sequences or posterior localisation.
(Gavis and Lehmann, 1994)
nos is involved in the directed intercalation of cells during germ band extension.
(Irvine and Wieschaus, 1994)
Comparisons of early development to that in other insects have revealed conservation of some aspects of development, as well as differences that may explain variations in early patterning events.
(Patel, 1994)
A screen for suppressors of nos mutations identified alleles of E(z). E(z) is required to maintain the expression domain of kni and gt initiated by the maternal hb gradient. A small region of the kni promoter mediates regulation by E(z) and hb. Imprinting at the chromatin level may underlie the determination of anteroposterior polarity in the early embryo.
(Pelegri and Lehmann, 1994)
Distribution of tud protein in mutant embryos has been studied.
(Bardsley et al., 1993)
pumilio, expressed in the same pattern as nanos, is not required for either the expression of nanos protein or its transport to the presumptive abdomen.
(Barker et al., 1992)
nanos 3' untranslated region is sufficient for nanos RNA localization. In experiments using bicoid sequences to mislocalise nanos, embryos with mirror image symmetry with double abdomens result if nanos is localised at both the anterior and posterior ends. Anteriorly localised nos suppresses translation of maternally supplied hunchback mRNA and thereby alters gap gene expression.
(Gavis and Lehmann, 1992)
Overexpression of osk leads to higher levels of osk mRNA that is both correctly localised to the posterior pole and unlocalised. Consequently nos is activated ectopically causing extensive shifts in body patterning. Germ cell formation is also affected, this can be enhanced by genetically decreasing nos activity.
(Smith et al., 1992)
nos acts to prevent the expression of hb in the posterior half of the embryo.
(Eldon and Pirrotta, 1991)
Expression from the Ecol\lacZ-Kr730 Kr-promoter fusion construct was monitored in nos- embryos to ensure the target site for nos mediated Kr expression has not been lost.
(Hoch et al., 1991)
gt may respond to the posterior morphogen nos in the embryo. nos represses maternal hb expression post-transcriptionally, so the effect of nos on gt expression may be mediated through hb.
(Kraut and Levine, 1991)
nos is critical for pole plasm formation and is required for the synthesis of the posterior signal in the nurse cells. The distribution of the signal to the presumptive posterior pole occurs after egg deposition. BicD,nos embryos suppress all abdominal development: the nos gene is critical for the normal and ectopic presence of the posterior signal.
(Lehmann and Nusslein-Volhard, 1991)
Mutations in maternal posterior class gene nos do not interact with RpII140wimp.
(Parkhurst and Ish-Horowicz, 1991)
nos gene product has been isolated and characterised.
(Wang and Lehmann, 1991)
The degree of regulation mediated by the NREs in maternal hb mRNA depends on the level of nos.
(Wharton and Struhl, 1991)
nos mutants exhibit deletion of the abdomen and pole plasm.
(Gaul and Jaeckle, 1990)
Mature follicles are immunologically stained for asymmetric distribution of ecdysteroid-related antigen. During late oogenesis localisation of the antigen changes dramatically suggesting the antigen plays a role in early embryogenesis and, perhaps, in pattern formation.
(Grau and Gutzeit, 1990)
nos gene function is not required for pole cell formation.
(Lasko and Ashburner, 1990)
nos plays a role in polar granule formation.
(Raff et al., 1990)
Double anterior structure induction in nos is more efficient by genetic methods, within nos mutant embryos, than removal of posterior cytoplasm.
(Sugiyama and Okada, 1990)
hide External Crossreferences & Linkouts
Sequence Crossreferences
RefSeq (Transcripts)
•
RefSeq (Proteins)
•
DDBJ / EMBL / GenBank
•
Entrez Gene - A searchable database of RefSeq genes.
•
UniProtKB/Swiss-Prot
•
UniProtKB/TrEMBL
•
Other Crossreferences
InterPro domains - A database of protein families, domains, and functional sites
•
Nanos/Xcat2 (IPR008705)
Zinc finger, CCHC-type (IPR001878)
Zinc finger, nanos-type (IPR024161)
Rfam - RNA families database of alignments and covariance models
•
Linkouts
BioGRID - A database of protein and genetic interactions
•
DroID - A comprehensive database of gene and protein interactions.
•
DRSC - Results from RNAi screens.
•
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
•
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
•
FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans
•
GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents
•
Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
•
InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets.
•
modMine - Data generated by the modENCODE project.
•
hide Synonyms & Secondary IDs ( 13 )
Reported As
Symbol Synonym
CG5637
(Laviolette et al., 2005, Keleman et al., 2009.8.5, Perkins et al., 2009, Ni et al., 2010.12.1)
DRONANOS
(Fernando Vazquez et al., 2000, Colson and Goldstein, 1999, Schug et al., 1998, Schug et al., 1997, Kennington et al., 2006)
Dronanos
(Lopez et al., 2002)
l(3)07117
 
l(3)j3B6
(Meister and Braun, 1995.10, BDGP Project Members, 1994-1999, )
l(3)j4B6
 
NANOS
(Colson and Goldstein, 1999)
nanos
(Muraro et al., 2008, Li et al., 2012)
nNOS
(Yamaguchi et al., 2006)
nos
(Jain and Gavis, 2007, Wawersik and Van, 2005, Anne et al., 2007, Deshpande et al., 2006, Deshpande et al., 2007, Gamberi and Lasko, 2007, Goldman et al., 2007, Kalifa and Gavis, 2007, McGregor, 2006, Laviolette et al., 2005, Shigenobu et al., 2006, Shapiro and Anderson, 2006, Arkov et al., 2006, Jeske et al., 2006, Zaessinger et al., 2006, Gavis et al., 2008, Sofola et al., 2007, McDermott et al., 2012, Maines et al., 2007, Zhang et al., 2007, Snowflack and Gavis, 2008, Lerit et al., 2008, Gamberi and Lasko, 2008, Lecuyer et al., 2007, Kadyrova et al., 2007, Xia et al., 2012, Weil et al., 2006, Sano et al., 2005, Jain and Gavis, 2008, Georlette et al., 2007, Song et al., 2007, Minidorff et al., 2007, Kim et al., 2011, Ali et al., 2010, Papatsenko and Levine, 2011, Fernandez-Gonzalez and Zallen, 2011, Minidorff et al., 2007, Sato et al., 2007, Blankenship et al., 2006, Tadros et al., 2007, Cinnamon et al., 2008, Benoit et al., 2008, Pope and Harris, 2008, Spirov et al., 2009, Brechbiel and Gavis, 2008, Weil et al., 2008, Verrotti et al., 1999, Rangan et al., 2009, Rhiner et al., 2009, Wang et al., 1994, Xie et al., 2005, Brechbiel and Gavis, 2008, Maezawa et al., 2009, Li et al., 2009, Chen et al., 2009, Fernandez-Gonzalez et al., 2009, Lim et al., 2009, Sheng et al., 2009, Kim et al., 2010, Becalska and Gavis, 2010, Flaherty et al., 2010, Jin et al., 2008, Leatherman and DiNardo, 2008, Kitadate and Kobayashi, 2010, Becalska et al., 2011, Jeske et al., 2011, Yatsu et al., 2008, Janic et al., 2010, Lerit and Gavis, 2011, Smibert et al., 1999, Garcia et al., 2011, Sinsimer et al., 2011, Parisi et al., 2004, Rouget et al., 2010, Tchuraev and Galimzyanov, 2009, Andrews et al., 2011, Pinder and Smibert, 2013, Takahashi et al., 2012, Chau et al., 2012, Rangan et al., 2008, Miles et al., 2012, Meier et al., 2012)
NOS
(Peel et al., 2005, Megosh et al., 2006, Megosh et al., 2006, Thomson and Lasko, 2004, Sofola et al., 2007)
Nos
(Trainor, 2004, Cho et al., 2006, Yu et al., 2008, Maines et al., 2008, Kim et al., 2010, Harris et al., 2011, Zhang et al., 2011, Kim et al., 2012, Kim et al., 2012)
Name Synonym
nanos
(Colson, 1998.5.26, Jain and Gavis, 2007, Wawersik and Van, 2005, Anne et al., 2007, Deshpande et al., 2007, Andrews and Gavis, 2007, Kalifa and Gavis, 2007, Ho and Gavis, 2007, Nystul and Spradling, 2006, Seydoux and Braun, 2006, Shigenobu et al., 2006, Shapiro and Anderson, 2006, Jeske et al., 2006, Zaessinger et al., 2006, Kalifa et al., 2006, Pavesi et al., 2004, Gavis et al., 2008, Lemke et al., 2008, Lerit et al., 2008, Shav-Tal and Singer, 2005, Jain and Gavis, 2008, Ali et al., 2010, Fernandez-Sanchez et al., 2010, Ishihara and Shibata, 2008, Blankenship et al., 2006, da Silva and Vincent, 2007, De Renzis et al., 2007, Cinnamon et al., 2008, Pope and Harris, 2008, Spirov et al., 2009, Brechbiel and Gavis, 2008, Weil et al., 2008, Parrish et al., 2007, McGraw et al., 2008, Rangan et al., 2009, Rhiner et al., 2009, Lu et al., 2009, Lim et al., 2009, Li et al., 2009, Sheng et al., 2009, Sato et al., 2008, Gurunathan et al., 2004, Martin et al., 2010, Holloway and Harrison, 1999, Jeske et al., 2011, Yatsu et al., 2008, Janic et al., 2010, Eliazer et al., 2011, Yu et al., 2010, Smibert et al., 1999, Johnson and Donaldson, 2006, Sinsimer et al., 2011, Scherp and Hasenstein, 2008, Rangan et al., 2008, Miles et al., 2012, Conte et al., 2012)
Nanos
(Pinder et al., 2007, Maines et al., 2007, Cho et al., 2006, Strome and Lehmann, 2007, Niki et al., 2006, Niki, 2006, Nurminsky, 2007, Maines et al., 2007, Yu et al., 2008, Nomie and Wharton, 2008, Kadyrova et al., 2007, Leatherman and DiNardo, 2008, Kitadate and Kobayashi, 2010, Kim et al., 2010, Tastan et al., 2010, Zhang et al., 2011, Kim et al., 2012, Chau et al., 2012)
Secondary FlyBase IDs
  • FBgn0010916
  • FBgn0011347
  • FBgn0011364
  • FBgn0026836
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hide Recent research papers ( 25 )
Pinder and Smibert, 2013, EMBO Rep. 14(1): 80--86
microRNA-independent recruitment of Argonaute 1 to nanos mRNA through the Smaug RNA-binding protein. [FBrf0220359]
Staller et al., 2013, Genetics 193(1): 51--61
Depleting Gene Activities in Early Drosophila Embryos with the "Maternal-Gal4-shRNA" System. [FBrf0220341]
Chau et al., 2012, Proc. Natl. Acad. Sci. U.S.A. 109(24): 9465--9470
Sex-lethal enables germline stem cell differentiation by down-regulating Nanos protein levels during Drosophila oogenesis. [FBrf0218549]
Conte et al., 2012, PLoS ONE 7(4): e34473
A biomechanical analysis of ventral furrow formation in the Drosophila melanogaster embryo. [FBrf0218026]
Kim et al., 2012, BMC Syst. Biol. 6: 31
Spatiotemporal network motif reveals the biological traits of developmental gene regulatory networks in Drosophila melanogaster. [FBrf0219366]
Kim et al., 2012, PLoS ONE 7(4): e34016
Negative Regulation of EGFR/MAPK Pathway by Pumilio in Drosophila melanogaster. [FBrf0218126]
Li et al., 2012, Development 139(9): 1547--1556
Mei-P26 regulates the maintenance of ovarian germline stem cells by promoting BMP signaling. [FBrf0218009]
McDermott et al., 2012, Biol. Open 1(5): 488--497
Drosophila Syncrip binds the gurken mRNA localisation signal and regulates localised transcripts during axis specification. [FBrf0218722]
Meier et al., 2012, PLoS Genet. 8(5): e1002676
LINT, a Novel dL(3)mbt-Containing Complex, Represses Malignant Brain Tumour Signature Genes. [FBrf0218194]
Miles et al., 2012, Genes Dev. 26(4): 356--368
Pumilio facilitates miRNA regulation of the E2F3 oncogene. [FBrf0217481]
Takahashi et al., 2012, Evolution 66(9): 2878--2890
Deficiency screening for genomic regions with effects on environmental sensitivity of the sensory bristles of Drosophila melanogaster. [FBrf0219405]
Weidmann and Goldstrohm, 2012, Mol. Cell. Biol. 32(2): 527--540
Drosophila Pumilio Protein Contains Multiple Autonomous Repression Domains That Regulate mRNAs Independently of Nanos and Brain Tumor. [FBrf0217089]
Xia et al., 2012, Curr. Biol. 22(6): 515--521
The Niche-Dependent Feedback Loop Generates a BMP Activity Gradient to Determine the Germline Stem Cell Fate. [FBrf0217877]
Andrews et al., 2011, RNA 17(5): 967--977
Multiple mechanisms collaborate to repress nanos translation in the Drosophila ovary and embryo. [FBrf0213495]
Becalska et al., 2011, Dev. Biol. 349(1): 46--52
Aubergine is a component of a nanos mRNA localization complex. [FBrf0212348]
Eliazer et al., 2011, Proc. Natl. Acad. Sci. U.S.A. 108(17): 7064--7069
Loss of lysine-specific demethylase 1 nonautonomously causes stem cell tumors in the Drosophila ovary. [FBrf0213593]
Fernandez-Gonzalez and Zallen, 2011, Phys. Biol. 8(4): 045005
Oscillatory behaviors and hierarchical assembly of contractile structures in intercalating cells. [FBrf0214479]
Garcia et al., 2011, BMC Mol. Biol. 12: 32
Functional characterization of the sciarid BhC4-1 core promoter in transgenic Drosophila. [FBrf0214770]
Harris et al., 2011, Dev. Cell 20(1): 72--83
Brat Promotes Stem Cell Differentiation via Control of a Bistable Switch that Restricts BMP Signaling. [FBrf0212787]
Jeske et al., 2011, EMBO J. 30(1): 90--103
Smaug assembles an ATP-dependent stable complex repressing nanos mRNA translation at multiple levels. [FBrf0212721]
Kim et al., 2011, Dev. Cell 20(6): 880--887
Gene regulation by MAPK substrate competition. [FBrf0213872]
Lerit and Gavis, 2011, Curr. Biol. 21(6): 439--448
Transport of germ plasm on astral microtubules directs germ cell development in Drosophila. [FBrf0213255]
Papatsenko and Levine, 2011, PLoS ONE 6(7): e21145
The Drosophila gap gene network is composed of two parallel toggle switches. [FBrf0214233]
Sinsimer et al., 2011, Development 138(16): 3431--3440
A late phase of germ plasm accumulation during Drosophila oogenesis requires Lost and Rumpelstiltskin. [FBrf0214542]
Zhang et al., 2011, Dev. Biol. 353(2): 259--265
Drosophila long-chain acyl-CoA synthetase acts like a gap gene in embryonic segmentation. [FBrf0213522]
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