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Gene Dmel\nos

General Information
Symbol	Dmel\nos	Species	D. melanogaster
Name	nanos	Annotation symbol	CG5637
Feature type	protein_coding_gene	FlyBase ID	FBgn0002962
Gene Model Status	Current	Stock availability	21 publicly available
Also Known As	DRONANOS, NANOS, l(3)j3B6
Genomic Location
Chromosome (arm)	3R	Recombination map	3-66.2
Cytogenetic map	91F4-91F4	Sequence location	3R:14,982,962..14,985,924 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene nanos is referred to in FlyBase by the symbol Dmel\nos (CG5637, FBgn0002962). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: protein binding. There is experimental evidence that it is involved in the biological process: germ-line stem cell maintenance; female meiosis chromosome segregation; dendrite morphogenesis; negative regulation of apoptosis; oogenesis; germ cell development; spermatogenesis. 269 alleles are reported. The phenotypes of these alleles are annotated with: embryonic abdomen; organ system; embryonic segment; organ system subdivision; germarium; cytoplasmic part; cephalopharyngeal skeleton; external compound sense organ; extended germ band embryo; adult segment. It has one annotated transcript and one annotated polypeptide. Protein features are: Nanos/Xcat2; Zinc finger, CCHC-type; Zinc finger, nanos-type. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of very low expression. Peak expression observed within 00-06 hour embryonic stages, in adult female stages. Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: adult ovary. Comments on Affy2 ProbeSet: ProbeSet 1632713_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of nos. Gene sequence location is 3R:14982962..14985924.
External Summaries
Phenotypic Description from the Red Book (Lindsley & Zimm 1992)
Gene/Allele symbols may differ from current usage	nos: nanos Maternal-effect lethal. Mutant embryos lack abdominal segments, but have normal pole cells and pole plasm; no posterior activity in pole plasm. Transport or diffusion of the nos gene product from the posterior of the embryo seems to be essential for development of the wild-type abdominal pattern. Presence of the nos protein represses the activity of of the gene product encoded by the hb maternal transcript in the posterior half of the embryo (Hulskamp et al., 1989; Irish et al., 1989; Struhl, 1989). Eggs deficient for both hb and nos, when fertilized by hb+ sperm, develop into normal embryos and subsequently into viable flies.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2012_01	Controlled Vocabulary Terms oogenesis stage S8 oocyte oogenesis stage S5 germline cell oogenesis stage S11 germarium region 1 oogenesis stage S4 faint oogenesis stage S14 nurse cell oogenesis stage S10 oogenesis stage S1 intense 0-30% egg length oogenesis stage S13 pole bud germarium region 2a oogenesis stage S7 oogenesis stage S6 oogenesis stage S3 oogenesis stage S12 oogenesis stage S10A Alleles nos[Deltapiroo] nos[Deltapiroo-Deltapi412] nos[Deltapi412] References Rouget et al., 2010, Nature 467(7319): 1128--1132 Tchuraev and Galimzyanov, 2009, J. Theor. Biol. 259(4): 659--669 Andrews et al., 2011, RNA 17(5): 967--977 Sequence features HFA17018 BKN20023
FB2011_10	References Gurunathan et al., 2004, BMC Bioinformatics 5: 202
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 91F4-91F4   Limits computationally determined from genome sequence between P{PZ}cdi07013&P{lacW}nosj3B6 and P{PZ}l(3)0334603346
Experimentally Determined Cytological Location
Cytogenetic map Notes References 91F4-91F5   (determined by in situ hybridisation)   (Spradling et al., 1999) 91F13-91F13   (determined by in situ hybridisation)   (Wang and Lehmann, 1990) 70A1-70A2   91E5--6   (BDGP Project Members, 1994-1999) 91F13-91F13   (determined by in situ hybridisation)   (Wang and Lehmann, 1991) 91F-92A     (Tearle and Nusslein-Volhard, 1987)
Experimentally Determined Recombination Data
Location	3-66.2 (Tearle and Nusslein-Volhard, 1987)
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\nos for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) nos-RA FBtr0083732  NM_057310   2347   401
Additional Transcript Data & Comments
Reported size (kB)	2.4 (northern blot) (Wang and Lehmann, 1991)
Comments
External Data
Crossreferences	Rfam - RNA families database of alignments and covariance models • RF00161
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein nos-PA   FBpp0083146   43.4   401   8.74     NP_476658   AAF55641
Additional Polypeptide Data & Comments
Reported size (kDa)	401 (aa); 43 (kD predicted) (Wang and Lehmann, 1991)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Nanos/Xcat2 (IPR008705) Zinc finger, CCHC-type (IPR001878) Zinc finger, nanos-type (IPR024161)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA978726   AE014297 AAF55641   AC006091   AF067873   AQ034086   AW943146   AY075406 AAL68233   BI367670   BP544781   BT132708   CL705877   CO281261   CO291667   CO324230   CO328218   CZ467207   CZ467208   EC086455   EC200802   EC245157   EC256492   EV579242   EV579719   EV591523   G00548   GH753740   GH756775   GH757281   GH761383   GH773960   GH774219   GH776078   GH778522   GH793667   GH799769   GH811837   GH820710   GH821199   GH822879   GH823366   GH827678   GH829918   GH839542   GH840358   GH841422   GH843294   GH846453   GH848843   GH849199   GH858370   GH873831   GH881967   GH885840   GH887783   GH888577   GH895992   GH899171   GH901630   GH902398   GH906064   GH918663   GH918998   GH921636   GH923267   GH924598   GH928738   GH936754   M72421 AAA28715
UniProtKB/Swiss-Prot	P25724
UniProtKB/TrEMBL	Q8SY38
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
No Assay Recorded Stage Tissue/Position (including subcellular localization) Reference embryonic stage | early   pole plasm   (Barker et al., 1992) organism | 0-10% egg length   (Gavis and Lehmann, 1992) Comment:0-2% egg length distribution deduced from reporter Stage Tissue/Position (including subcellular localization) Reference adult stage | female   stage S4 oocyte & stage S5 oocyte & stage S6 oocyte   • cell cortex (Forrest and Gavis, 2003) stage S8 oocyte | anterior & stage S9 oocyte | anterior   (Forrest and Gavis, 2003) stage S11 oocyte | posterior & stage S12 oocyte | posterior & stage S13 oocyte | posterior & stage S14 oocyte | posterior   • cell cortex (Forrest and Gavis, 2003) in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage   organism | posterior   (Bergsten and Gavis, 1999) embryonic stage | early   organism | anterior   (Gavis and Lehmann, 1992) embryonic stage 1 -- 2   organism | posterior   (Wang and Lehmann, 1991) organism | 0-10% egg length   (Polesello et al., 2002, Wang et al., 1994) Comment:posterior pole pole plasm   (Wang et al., 1994) embryonic stage 1 -- 3   organism | posterior   • germ plasm (Robertson et al., 1999) organism | posterior   • perinuclear region of cytoplasm of germ cell nucleus (Robertson et al., 1999) embryonic stage 2   organism | posterior   (Bergsten and Gavis, 1999) organism | 0-10% egg length   (Bergsten and Gavis, 1999) Comment:0-5% egg length embryonic stage 3   pole bud   (Wang et al., 1994) Comment:early stage 3 pole cell   (Wang et al., 1994) Comment:late stage 3 embryonic stage 4 -- 11   pole cell   (Wang et al., 1994) oogenesis stage S5 -- S6   nurse cell   (Wang et al., 1994) oocyte   (Wang et al., 1994) oogenesis stage S7 -- S8   oocyte | anterior & restricted   (Wang et al., 1994) oogenesis stage S10A   nurse cell   (Wang et al., 1994) oogenesis stage S11 -- S12   oocyte   (Wang et al., 1994) oogenesis stage S13 -- S14   oocyte | posterior   (Wang et al., 1994) northern blot Stage Tissue/Position (including subcellular localization) Reference embryonic stage 1 -- 12     (Wang and Lehmann, 1991) Comment:reference states 0-8 hr AEL embryonic stage 3 -- 9   pole cell   (Wang and Lehmann, 1991) oogenesis     (Wang and Lehmann, 1991)
Additional Descriptive Data
	The 2.4 kb nos transcript is detected at high levels in ovaries and in 0-2 hour embryos, and at much lower levels in 2-8 hour embryos. This transcript is not detected in older embryos, larvae, or pupae. The nos transcript localizes to the posterior pole of stage 1-2 embryos. The levels of nos transcript in pole cells are high at stage 3 and 4, and have declined dramatically by early germ band extension (stage 8), with no pole cell-specific staining detected after stage 10. (Wang and Lehmann, 1991) nos transcripts containing a bcd3'UTR are localized at the anterior end of embryos in a distributionresembling the wild type bcd pattern. (Gavis and Lehmann, 1992) During oogenesis, nos transcipt is first clearly detected at stage S5, in both nurse cells and oocytes. At stage S7-8, nos transcript transiently localizes to the anterior margin of the oocyte. At stage S10, a high level of nos transcript is present in oocytes; this transcript subsequently dumped into the oocyte. By stage S12, nos transcript begins to accumulate at the posterior pole of the oocyte, and is localized to the posterior pole of the oocyte at the later stages of oogenesis. In embryos, nos transcript is undetectable after germ band extension. (Wang et al., 1994) in situ hybridization detects a localized nos transcript at the posterior pole in embryos, however, northern blot analysis detects high transcript levels in both anterior and posterior embryo halves, indicating that transcript is expressed uniformly, and subsequently localized to the posterior pole. (Bergsten and Gavis, 1999) As deduced from GFP labeled nos transcripts in early egg chambers nos transcript localizes to the posterior of the oocyte. There is a transient redistribution to an anterior ring at the margin of the oocyte during stages 8 and 9. nos transcript is no longer detected in the oocyte at stage 10. At stage 10b nurse cell dumping is initiated and by stage 11 nos transcript can be detected in the posterior cortex of the oocyte with a punctate distribution. Cooccurence with vas protein suggests that nos transcript associates with the germ plasm. Maximum accumulation of nos transcript is observed at stage 13/14. (Forrest and Gavis, 2003) In wild type and in pum mutant embryos, nos RNA is localized to the posterior pole plasm. (Barker et al., 1992) Wild type nos transcripts are expressed in a wild type pattern at the posterior pole in nosbcd.3UTR embryos. wild type nos transcripts are absent in nosbcd.3UTR embryos from osk1 females. (Gavis and Lehmann, 1992)
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
No Assay Recorded Stage Tissue/Position (including subcellular localization) Reference embryonic stage | early   organism | gradient & posterior   (Barker et al., 1992) organism | gradient   (Gavis and Lehmann, 1992) immunolocalization Stage Tissue/Position (including subcellular localization) Reference embryonic stage 1   organism | 0-10% egg length   (Wang et al., 1994) Comment:posterior pole embryonic stage 2   organism | 0-20% egg length   (Gavis and Lehmann, 1994) embryonic stage 3   organism | 0-30% egg length & gradient   (Wang et al., 1994) Comment:early stage 3 pole cell   (Wang et al., 1994) Comment:late stage 3 embryonic stage 5   pole cell   (Matova and Cooley, 2001) embryonic stage 6 -- 15   germline stem cell   (Matova and Cooley, 2001) embryonic stage 12 -- 15   germline cell   (Wang et al., 1994) third instar larval stage   germline stem cell & cystoblast   (Gilboa and Lehmann, 2004) Comment:in primordial germ cell (PGC), at mid-third instar (ML3, 96hr AEL) germline cyst   (Gilboa and Lehmann, 2004) adult stage | female   germline stem cell & cystoblast   (Gilboa and Lehmann, 2004) germline cyst   (Gilboa and Lehmann, 2004) adult stage & oogenesis   germline cyst of germarium region 2   (Forbes and Lehmann, 1998) female germline stem cell   (Forbes and Lehmann, 1998) cystoblast   (Forbes and Lehmann, 1998) oogenesis stage S1   germarium region 1   (Wang et al., 1994) germarium region 2a   (Wang et al., 1994) oogenesis stage S3 -- S6   nurse cell | faint   (Wang et al., 1994) oogenesis stage S10   nurse cell | intense   (Wang et al., 1994) in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage 4 -- 11   pole cell   (Wang et al., 1994)
Additional Descriptive Data
	During oogenesis, nos protein can be detected strongly in germarium region 1, and weakly in germarium region 2a. Low levels of nos protein can be observed in nurse cell/oocyte clusters at stages S3-6, and high levels in nurse cells at stage S10. nos protein is never observed in oocytes. After pole bud formation in embryos, nos protein is rapidly degraded outside of the pole cells. nos protein is observed in embryonic germline cells as late as embryonic stage 15. (Wang et al., 1994) Highest levels of nos protein in the germarium are detected in germline cysts in region 2. Levels decline as the cysts are encapsulated by somatic cells. Lower levels of nos protein have previously been observed in the germline stem cells and dividing cystoblasts (FBrf0074750). (Forbes and Lehmann, 1998) In wild type embryos, nos protein forms a concentration gradient emanating from the posterior pole and extending into the presumptive abdomen. nos protein distribution is indistinguishable in wild type and pum mutant embryos, as assayed by filtered fluorescence-imaging. (Barker et al., 1992) nos protein is expressed in opposing gradients emanating from the anterior and posterior poles of the embryo in nosbcd.3UTR embryos. In nosbcd.3UTR embryos from osk1 mothers, a single gradient of nos expression emanates from the anterior pole. (Gavis and Lehmann, 1992)
Marker for
	germline stem cell
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0002962    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0002962 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of very low expression. Peak expression observed within 00-06 hour embryonic stages, in adult female stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0002962 expression level Developmental Stage   Expression Level embryo 00-02hr    14849 embryo 02-04hr    1411 embryo 04-06hr    591 embryo 06-08hr    197 embryo 08-10hr    219 embryo 10-12hr    156 embryo 12-14hr    85 embryo 14-16hr    119 embryo 16-18hr    73 embryo 18-20hr    86 embryo 20-22hr    89 embryo 22-24hr    112 larva L1    93 larva L2    72 larva L3 12hr old    53 larva L3 puffstage 1-2    39 larva L3 puffstage 3-6    41 larva L3 puffstage 7-9    49 white prepupae new    59 white prepupae 12hr    91 white prepupae 24hr    101 pupae 2d postWPP    127 pupae 3d postWPP    101 pupae 4d postWPP    114 adult male 01day    139 adult male 05day    156 adult male 30day    159 adult female 01day    4195 adult female 05day    9445 adult female 30day    10132 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (14849) embryo 02-04hr  (1411) embryo 04-06hr  (591) embryo 06-08hr  (197) embryo 08-10hr  (219) embryo 10-12hr  (156) embryo 12-14hr    85 embryo 14-16hr  (119) embryo 16-18hr    73 embryo 18-20hr    86 embryo 20-22hr    89 embryo 22-24hr  (112) larva L1    93 larva L2    72 larva L3 12hr old    53 larva L3 puffstage 1-2    39 larva L3 puffstage 3-6    41 larva L3 puffstage 7-9    49 white prepupae new    59 white prepupae 12hr    91 white prepupae 24hr  101 pupae 2d postWPP  (127) pupae 3d postWPP  101 pupae 4d postWPP  (114) adult male 01day  (139) adult male 05day  (156) adult male 30day  (159) adult female 01day  (4195) adult female 05day  (9445) adult female 30day  (10132) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (14849) embryo 02-04hr  1411 embryo 04-06hr    591 embryo 06-08hr    197 embryo 08-10hr    219 embryo 10-12hr    156 embryo 12-14hr    85 embryo 14-16hr    119 embryo 16-18hr    73 embryo 18-20hr    86 embryo 20-22hr    89 embryo 22-24hr    112 larva L1    93 larva L2    72 larva L3 12hr old    53 larva L3 puffstage 1-2    39 larva L3 puffstage 3-6    41 larva L3 puffstage 7-9    49 white prepupae new    59 white prepupae 12hr    91 white prepupae 24hr    101 pupae 2d postWPP    127 pupae 3d postWPP    101 pupae 4d postWPP    114 adult male 01day    139 adult male 05day    156 adult male 30day    159 adult female 01day  (4195) adult female 05day  (9445) adult female 30day  (10132) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr  (14849) embryo 02-04hr    1411 embryo 04-06hr    591 embryo 06-08hr    197 embryo 08-10hr    219 embryo 10-12hr    156 embryo 12-14hr    85 embryo 14-16hr    119 embryo 16-18hr    73 embryo 18-20hr    86 embryo 20-22hr    89 embryo 22-24hr    112 larva L1    93 larva L2    72 larva L3 12hr old    53 larva L3 puffstage 1-2    39 larva L3 puffstage 3-6    41 larva L3 puffstage 7-9    49 white prepupae new    59 white prepupae 12hr    91 white prepupae 24hr    101 pupae 2d postWPP    127 pupae 3d postWPP    101 pupae 4d postWPP    114 adult male 01day    139 adult male 05day    156 adult male 30day    159 adult female 01day    4195 adult female 05day    9445 adult female 30day  10132 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    14849 embryo 02-04hr    1411 embryo 04-06hr    591 embryo 06-08hr    197 embryo 08-10hr    219 embryo 10-12hr    156 embryo 12-14hr    85 embryo 14-16hr    119 embryo 16-18hr    73 embryo 18-20hr    86 embryo 20-22hr    89 embryo 22-24hr    112 larva L1    93 larva L2    72 larva L3 12hr old    53 larva L3 puffstage 1-2    39 larva L3 puffstage 3-6    41 larva L3 puffstage 7-9    49 white prepupae new    59 white prepupae 12hr    91 white prepupae 24hr    101 pupae 2d postWPP    127 pupae 3d postWPP    101 pupae 4d postWPP    114 adult male 01day    139 adult male 05day    156 adult male 30day    159 adult female 01day    4195 adult female 05day    9445 adult female 30day    10132 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0002962 expression level Developmental Stage   Expression Level embryo 00-02hr    14849 embryo 02-04hr    1411 embryo 04-06hr    591 embryo 06-08hr    197 embryo 08-10hr    219 embryo 10-12hr    156 embryo 12-14hr    85 embryo 14-16hr    119 embryo 16-18hr    73 embryo 18-20hr    86 embryo 20-22hr    89 embryo 22-24hr    112 larva L1    93 larva L2    72 larva L3 12hr old    53 larva L3 puffstage 1-2    39 larva L3 puffstage 3-6    41 larva L3 puffstage 7-9    49 white prepupae new    59 white prepupae 12hr    91 white prepupae 24hr    101 pupae 2d postWPP    127 pupae 3d postWPP    101 pupae 4d postWPP    114 adult male 01day    139 adult male 05day    156 adult male 30day    159 adult female 01day    4195 adult female 05day    9445 adult female 30day    10132 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (14849) embryo 02-04hr  (1411) embryo 04-06hr  (591) embryo 06-08hr  (197) embryo 08-10hr  (219) embryo 10-12hr  (156) embryo 12-14hr    85 embryo 14-16hr  119 embryo 16-18hr    73 embryo 18-20hr    86 embryo 20-22hr    89 embryo 22-24hr  112 larva L1    93 larva L2    72 larva L3 12hr old    53 larva L3 puffstage 1-2    39 larva L3 puffstage 3-6    41 larva L3 puffstage 7-9    49 white prepupae new    59 white prepupae 12hr    91 white prepupae 24hr  101 pupae 2d postWPP  127 pupae 3d postWPP  101 pupae 4d postWPP  114 adult male 01day  139 adult male 05day  (156) adult male 30day  (159) adult female 01day  (4195) adult female 05day  (9445) adult female 30day  (10132) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (14849) embryo 02-04hr  1411 embryo 04-06hr    591 embryo 06-08hr    197 embryo 08-10hr    219 embryo 10-12hr    156 embryo 12-14hr    85 embryo 14-16hr    119 embryo 16-18hr    73 embryo 18-20hr    86 embryo 20-22hr    89 embryo 22-24hr    112 larva L1    93 larva L2    72 larva L3 12hr old    53 larva L3 puffstage 1-2    39 larva L3 puffstage 3-6    41 larva L3 puffstage 7-9    49 white prepupae new    59 white prepupae 12hr    91 white prepupae 24hr    101 pupae 2d postWPP    127 pupae 3d postWPP    101 pupae 4d postWPP    114 adult male 01day    139 adult male 05day    156 adult male 30day    159 adult female 01day  (4195) adult female 05day  (9445) adult female 30day  (10132) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr  14849 embryo 02-04hr    1411 embryo 04-06hr    591 embryo 06-08hr    197 embryo 08-10hr    219 embryo 10-12hr    156 embryo 12-14hr    85 embryo 14-16hr    119 embryo 16-18hr    73 embryo 18-20hr    86 embryo 20-22hr    89 embryo 22-24hr    112 larva L1    93 larva L2    72 larva L3 12hr old    53 larva L3 puffstage 1-2    39 larva L3 puffstage 3-6    41 larva L3 puffstage 7-9    49 white prepupae new    59 white prepupae 12hr    91 white prepupae 24hr    101 pupae 2d postWPP    127 pupae 3d postWPP    101 pupae 4d postWPP    114 adult male 01day    139 adult male 05day    156 adult male 30day    159 adult female 01day    4195 adult female 05day    9445 adult female 30day  10132 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    14849 embryo 02-04hr    1411 embryo 04-06hr    591 embryo 06-08hr    197 embryo 08-10hr    219 embryo 10-12hr    156 embryo 12-14hr    85 embryo 14-16hr    119 embryo 16-18hr    73 embryo 18-20hr    86 embryo 20-22hr    89 embryo 22-24hr    112 larva L1    93 larva L2    72 larva L3 12hr old    53 larva L3 puffstage 1-2    39 larva L3 puffstage 3-6    41 larva L3 puffstage 7-9    49 white prepupae new    59 white prepupae 12hr    91 white prepupae 24hr    101 pupae 2d postWPP    127 pupae 3d postWPP    101 pupae 4d postWPP    114 adult male 01day    139 adult male 05day    156 adult male 30day    159 adult female 01day    4195 adult female 05day    9445 adult female 30day    10132 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0002962    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0002962 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: adult ovary. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0002962 expression level Tissue   Expression Level Larval Central Nervous System    2.6 Larval Midgut    8.8 Larval Hindgut    4.6 Larval Malpighian Tubules    5.2 Larval Fat Body no informative data Larval Salivary Gland    2.3 Larval Trachea    1.375 Larval Carcass    1.375 Adult Head    2 Adult Eye    2.425 Adult Brain    2.9 Adult Thoracic-Abdominal Ganglion    4 Adult Crop    4.6 Adult Midgut    2 Adult Hindgut    1.4 Adult Malpighian Tubules no informative data Adult Fat Body no informative data Adult Salivary Gland no informative data Adult Heart    0.325 Adult VirginFemale Spermatheca    18.2 Adult InseminatedFemale Spermatheca    9.4 Adult Ovary    2058.6 Adult Testis    37.7 Adult Male Accessory Gland    2.7 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    2.6 Larval Midgut    8.8 Larval Hindgut    4.6 Larval Malpighian Tubules    5.2 Larval Fat Body no informative data Larval Salivary Gland    2.3 Larval Trachea    1.375 Larval Carcass    1.375 Adult Head    2 Adult Eye    2.425 Adult Brain    2.9 Adult Thoracic-Abdominal Ganglion    4 Adult Crop    4.6 Adult Midgut    2 Adult Hindgut    1.4 Adult Malpighian Tubules no informative data Adult Fat Body no informative data Adult Salivary Gland no informative data Adult Heart    0.325 Adult VirginFemale Spermatheca    18.2 Adult InseminatedFemale Spermatheca    9.4 Adult Ovary  (2058.6) Adult Testis    37.7 Adult Male Accessory Gland    2.7 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    2.6 Larval Midgut    8.8 Larval Hindgut    4.6 Larval Malpighian Tubules    5.2 Larval Fat Body no informative data Larval Salivary Gland    2.3 Larval Trachea    1.375 Larval Carcass    1.375 Adult Head    2 Adult Eye    2.425 Adult Brain    2.9 Adult Thoracic-Abdominal Ganglion    4 Adult Crop    4.6 Adult Midgut    2 Adult Hindgut    1.4 Adult Malpighian Tubules no informative data Adult Fat Body no informative data Adult Salivary Gland no informative data Adult Heart    0.325 Adult VirginFemale Spermatheca    18.2 Adult InseminatedFemale Spermatheca    9.4 Adult Ovary  (2058.6) Adult Testis    37.7 Adult Male Accessory Gland    2.7 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    2.6 Larval Midgut    8.8 Larval Hindgut    4.6 Larval Malpighian Tubules    5.2 Larval Fat Body no informative data Larval Salivary Gland    2.3 Larval Trachea    1.375 Larval Carcass    1.375 Adult Head    2 Adult Eye    2.425 Adult Brain    2.9 Adult Thoracic-Abdominal Ganglion    4 Adult Crop    4.6 Adult Midgut    2 Adult Hindgut    1.4 Adult Malpighian Tubules no informative data Adult Fat Body no informative data Adult Salivary Gland no informative data Adult Heart    0.325 Adult VirginFemale Spermatheca    18.2 Adult InseminatedFemale Spermatheca    9.4 Adult Ovary    2058.6 Adult Testis    37.7 Adult Male Accessory Gland    2.7 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0002962 expression level Tissue   Expression Level Larval Central Nervous System    2.6 Larval Midgut    8.8 Larval Hindgut    4.6 Larval Malpighian Tubules    5.2 Larval Fat Body no informative data Larval Salivary Gland    2.3 Larval Trachea    1.375 Larval Carcass    1.375 Adult Head    2 Adult Eye    2.425 Adult Brain    2.9 Adult Thoracic-Abdominal Ganglion    4 Adult Crop    4.6 Adult Midgut    2 Adult Hindgut    1.4 Adult Malpighian Tubules no informative data Adult Fat Body no informative data Adult Salivary Gland no informative data Adult Heart    0.325 Adult VirginFemale Spermatheca    18.2 Adult InseminatedFemale Spermatheca    9.4 Adult Ovary    2058.6 Adult Testis    37.7 Adult Male Accessory Gland    2.7 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    2.6 Larval Midgut    8.8 Larval Hindgut    4.6 Larval Malpighian Tubules    5.2 Larval Fat Body no informative data Larval Salivary Gland    2.3 Larval Trachea    1.375 Larval Carcass    1.375 Adult Head    2 Adult Eye    2.425 Adult Brain    2.9 Adult Thoracic-Abdominal Ganglion    4 Adult Crop    4.6 Adult Midgut    2 Adult Hindgut    1.4 Adult Malpighian Tubules no informative data Adult Fat Body no informative data Adult Salivary Gland no informative data Adult Heart    0.325 Adult VirginFemale Spermatheca    18.2 Adult InseminatedFemale Spermatheca    9.4 Adult Ovary  (2058.6) Adult Testis    37.7 Adult Male Accessory Gland    2.7 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    2.6 Larval Midgut    8.8 Larval Hindgut    4.6 Larval Malpighian Tubules    5.2 Larval Fat Body no informative data Larval Salivary Gland    2.3 Larval Trachea    1.375 Larval Carcass    1.375 Adult Head    2 Adult Eye    2.425 Adult Brain    2.9 Adult Thoracic-Abdominal Ganglion    4 Adult Crop    4.6 Adult Midgut    2 Adult Hindgut    1.4 Adult Malpighian Tubules no informative data Adult Fat Body no informative data Adult Salivary Gland no informative data Adult Heart    0.325 Adult VirginFemale Spermatheca    18.2 Adult InseminatedFemale Spermatheca    9.4 Adult Ovary  (2058.6) Adult Testis    37.7 Adult Male Accessory Gland    2.7 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    2.6 Larval Midgut    8.8 Larval Hindgut    4.6 Larval Malpighian Tubules    5.2 Larval Fat Body no informative data Larval Salivary Gland    2.3 Larval Trachea    1.375 Larval Carcass    1.375 Adult Head    2 Adult Eye    2.425 Adult Brain    2.9 Adult Thoracic-Abdominal Ganglion    4 Adult Crop    4.6 Adult Midgut    2 Adult Hindgut    1.4 Adult Malpighian Tubules no informative data Adult Fat Body no informative data Adult Salivary Gland no informative data Adult Heart    0.325 Adult VirginFemale Spermatheca    18.2 Adult InseminatedFemale Spermatheca    9.4 Adult Ovary    2058.6 Adult Testis    37.7 Adult Male Accessory Gland    2.7 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body no informative data Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules no informative data Adult Fat Body no informative data Adult Salivary Gland no informative data Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass no informative data FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    2   NA  Eye    2.425   NA  Brain    2.9   2.6  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    4   NA  Crop    4.6   8.8  Midgut    2   4.6  Hindgut    1.4   5.2  Malpighian Tubules    no informative data   no informative data  Fat Body    no informative data   2.3  Salivary Gland    no informative data   NA  Heart    0.325   1.375  Trachea    NA   NA  VirginFemale Spermatheca    18.2   NA  InseminatedFemale Spermatheca    9.4   NA  Ovary    2058.6   NA  Testis    37.7   NA  Male Accessory Gland    2.7   1.375  Carcass    no informative data modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_13
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0002962 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG5637-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal, with Scer\GAL4h-1J3 nosαTub84B.3'UTR.nos+2.Scer\UAS nosαTub84B.3'UTR.nosTCE.Scer\UAS nosαTub84B.3'UTR.Scer\UAS lethal, with Scer\GAL4HD34A nosαTub84B.3'UTR.nosB1m.TCEIIU.B3m1.Scer\UAS nosαTub84B.3'UTR.nosB3m1.Scer\UAS nosαTub84B.3'UTR.nosB3m2.Scer\UAS nosαTub84B.3'UTR.nosNR.Scer\UAS nosαTub84B.3'UTR.nosTCEIIU.B3m1.Scer\UAS nosαTub84B.3'UTR.Scer\UAS lethal, with Scer\GAL4how-24B nosαTub84B.3'UTR.Brd.Scer\UAS nosαTub84B.3'UTR.nos+2.Scer\UAS nosαTub84B.3'UTR.nosTCE.Scer\UAS nosαTub84B.3'UTR.Scer\UAS lethal | dominant | embryonic stage | maternal effect nosαTub84B.UTR.T:Ivir\HA1 lethal | dominant | maternal effect nosbcd.3UTR nosΔTCE lethal | embryonic stage | maternal effect nos3xSRE- nosb.n.1-16 nosb.n.1-32 nosb.n.1-48 nosb.n.1-64 nosb.n.41-96 nosb.n.61-96 nosb.n.96-1.T:Ivir\HA1 nosb.n.96-1 nosb.n.T:Ivir\HA1 nosbcd.3UTR.D nosbcdUTR.nos nosSRE1.SRE2 nosTCE2 nosTCE7 nosTCE8 lethal | maternal effect | recessive nos17 nos18 nos53 nosL7 lethal | partially, with Scer\GAL41407 nosαTub84B.3'UTR.nos+2.Scer\UAS nosαTub84B.3'UTR.Scer\UAS lethal | partially, with Scer\GAL4elav.PLu nosαTub84B.3'UTR.nos+2.Scer\UAS nosαTub84B.3'UTR.Scer\UAS lethal | pupal stage, with Scer\GAL4pnr-MD237 nosGD11715 lethal | recessive nos01536 nos07117 nosj3B6 nosj4B6 semi-lethal, with Scer\GAL4h-1J3 nosαTub84B.3'UTR.Brd.Scer\UAS semi-lethal, with Scer\GAL4HD34A nosαTub84B.3'UTR.Brd.Scer\UAS nosαTub84B.3'UTR.nos+2.Scer\UAS nosαTub84B.3'UTR.nosSRE.Scer\UAS nosαTub84B.3'UTR.nosTCE.Scer\UAS nosαTub84B.3'UTR.nosTCEIIA.IIIA.Scer\UAS nosαTub84B.3'UTR.nosTCEIIA.Scer\UAS nosαTub84B.3'UTR.nosTCEIIIA.Scer\UAS nosαTub84B.3'UTR.nosTCEIIU.Scer\UAS semi-lethal | embryonic stage | recessive nosScim semi-viable | embryonic stage | maternal effect nosΔEX viable nosEY01331 viable, with Scer\GAL47B nosUY4741 nosαTub84B.3'UTR.Scer\UAS viable, with Scer\GAL4HD34A nosΔB.αTub84B.3'UTR.nos+2.Scer\UAS nosαTub84B.3'UTR.pho.Scer\UAS Sterility Allele female fertile nos3.αTub84B.UTR.T:Ivir\HA1 nos6.αTub84B.UTR.T:Ivir\HA1 nos18.αTub84B.UTR.T:Ivir\HA1 nos19.αTub84B.UTR.T:Ivir\HA1 nos108.αTub84B.UTR.T:Ivir\HA1 nos111.αTub84B.UTR.T:Ivir\HA1 nos122.αTub84B.UTR.T:Ivir\HA1 nos139.αTub84B.UTR.T:Ivir\HA1 nos153.αTub84B.UTR.T:Ivir\HA1 nos154.αTub84B.UTR.T:Ivir\HA1 nos165.αTub84B.UTR.T:Ivir\HA1 nos183.αTub84B.UTR.T:Ivir\HA1 nos197.αTub84B.UTR.T:Ivir\HA1 nos204.αTub84B.UTR.T:Ivir\HA1 nos212.αTub84B.UTR.T:Ivir\HA1 nos243.αTub84B.UTR.T:Ivir\HA1 nos246.αTub84B.UTR.T:Ivir\HA1 nos253.αTub84B.UTR.T:Ivir\HA1 nos254.αTub84B.UTR.T:Ivir\HA1 nos258.αTub84B.UTR.T:Ivir\HA1 nos263.αTub84B.UTR.T:Ivir\HA1 nos264.αTub84B.UTR.T:Ivir\HA1 nos272.αTub84B.UTR.T:Ivir\HA1 nos273.αTub84B.UTR.T:Ivir\HA1 nos277.αTub84B.UTR.T:Ivir\HA1 nos286.αTub84B.UTR.T:Ivir\HA1 nos295.αTub84B.UTR.T:Ivir\HA1 nos505.αTub84B.UTR.T:Ivir\HA1 nos506.αTub84B.UTR.T:Ivir\HA1 nos512.αTub84B.UTR.T:Ivir\HA1 nos516.αTub84B.UTR.T:Ivir\HA1 nos517.αTub84B.UTR.T:Ivir\HA1 nos520.αTub84B.UTR.T:Ivir\HA1 nos524.αTub84B.UTR.T:Ivir\HA1 nos526.αTub84B.UTR.T:Ivir\HA1 nos538.αTub84B.UTR.T:Ivir\HA1 nos539.αTub84B.UTR.T:Ivir\HA1 nos549.αTub84B.UTR.T:Ivir\HA1 nos554.αTub84B.UTR.T:Ivir\HA1 nos558.αTub84B.UTR.T:Ivir\HA1 nos560.αTub84B.UTR.T:Ivir\HA1 nos565.αTub84B.UTR.T:Ivir\HA1 nos568.αTub84B.UTR.T:Ivir\HA1 nos579.αTub84B.UTR.T:Ivir\HA1 nos581.αTub84B.UTR.T:Ivir\HA1 nos585.αTub84B.UTR.T:Ivir\HA1 nos587.αTub84B.UTR.T:Ivir\HA1 nos592.αTub84B.UTR.T:Ivir\HA1 nos594.αTub84B.UTR.T:Ivir\HA1 nos595.αTub84B.UTR.T:Ivir\HA1 nos599.αTub84B.UTR.T:Ivir\HA1 nos607.αTub84B.UTR.T:Ivir\HA1 nos614.αTub84B.UTR.T:Ivir\HA1 nos620.αTub84B.UTR.T:Ivir\HA1 nos623.αTub84B.UTR.T:Ivir\HA1 nos626.αTub84B.UTR.T:Ivir\HA1 nos627.αTub84B.UTR.T:Ivir\HA1 nos635.αTub84B.UTR.T:Ivir\HA1 nos641.αTub84B.UTR.T:Ivir\HA1 nos672.αTub84B.UTR.T:Ivir\HA1 female sterile nos18 female sterile (with Df(3R)Dl-FX1) nos18 female sterile (with Df(3R)nos) nos18 female sterile | dominant nosbcd.3UTR nosαTub84B.UTR.T:Ivir\HA1 female sterile | recessive nos05678 fertile nosEY01331 Other Phenotypes Allele meiotic cell cycle defective | dominant nosScim neuroanatomy defective, with Scer\GAL47B nosUY4741 neuroanatomy defective, with Scer\GAL48-123 nosαTub84B.3'UTR.nos+2.Scer\UAS nosαTub84B.3'UTR.Scer\UAS neuroanatomy defective, with Scer\GAL4109(2)80 nosαTub84B.3'UTR.Scer\UAS neuroanatomy defective, with Scer\GAL4477 nosαTub84B.3'UTR.Scer\UAS neuroanatomy defective, with Scer\GAL4ey-OK107 nosUY4741 nosαTub84B.3'UTR.Scer\UAS neuroanatomy defective | late third instar larval stage (with Df(3R)Dl-X43) nos18 neuroanatomy defective | late third instar larval stage (with nos18) nos53 neuroanatomy defective | late third instar larval stage (with nos53) nos18 neuroanatomy defective | somatic clone nos18 neuroanatomy defective | third instar larval stage nosgnosGRH- nosgnosSREs-.GRH- nosgnosSREs- nosαTub84B.UTR.T:Ivir\HA1 visible nosGMR.PW visible, with Scer\GAL4GMR.PF nosαTub84B.3'UTR.nos+2.Scer\UAS nosαTub84B.3'UTR.Scer\UAS visible, with Scer\GAL4hs.2sev nosαTub84B.3'UTR.nos+2.Scer\UAS nosαTub84B.3'UTR.Scer\UAS wild-type nos+4.4.T:Ivir\HA1 nos+mSa nos+t5.7 nosfl.cCa nosN5 nosnos.+1.+2' nosnos.+2.Hsp83 nosnos.+2'-3X.T:Ivir\HA1 nosnos.+2'A-3X.T:Ivir\HA1 nosnos.+2'B-3X.T:Ivir\HA1 nosnos.+2'C-3X.T:Ivir\HA1 nosnos.+2'D-3X.T:Ivir\HA1 nosnos.+2'ME-3X.T:Ivir\HA1 nosT:Hsap\MYC nosTCE.IIIA:U nosTCE.IIIA.Tloop nosTCE.IIIA nosTCE.IIIGC:GC nosTCE.IIIGC nosTCE.IIIU nosTCEIIA nosTCEIIU nosΔ218-287 nosΔA nosΔB nosΔBX nosΔC nosΔD nosΔE nosΔF nosΔG Phenotype manifest in Allele abdomen nos18 nos53 nosL7 abdomen | ectopic nosbcd.3UTR abdominal 1 ventral denticle belt | maternal effect nosbcd.3UTR abdominal 2 ventral denticle belt | maternal effect nosbcd.3UTR abdominal 3 ventral denticle belt | maternal effect nosbcd.3UTR abdominal 4 ventral denticle belt | maternal effect nosbcd.3UTR abdominal 5 ventral denticle belt | maternal effect nosbcd.3UTR abdominal 6 ventral denticle belt | maternal effect nosbcd.3UTR abdominal 7 ventral denticle belt | maternal effect nosbcd.3UTR abdominal segment nosBN nosL7 abdominal segment, with nos+1+3.T:MS2\MCP.BS nosBN abdominal segment, with nosBN nos+1+3.T:MS2\MCP.BS adult cuticle, with Scer\GAL4Eh.2.4 nosαTub84B.3'UTR.Scer\UAS nosαTub84B.3'UTR.nos+2.Scer\UAS adult cuticle, with Scer\GAL4HD23A nosαTub84B.3'UTR.Scer\UAS nosαTub84B.3'UTR.nos+2.Scer\UAS adult cuticle, with Scer\GAL4HD44A nosαTub84B.3'UTR.Scer\UAS nosαTub84B.3'UTR.nos+2.Scer\UAS adult cuticle, with Scer\GAL4hs.2sev nosαTub84B.3'UTR.Scer\UAS nosαTub84B.3'UTR.nos+2.Scer\UAS adult cuticle, with Scer\GAL4KF42A nosαTub84B.3'UTR.Scer\UAS adult cuticle, with Scer\GAL4sca-109-68 nosαTub84B.3'UTR.Scer\UAS nosαTub84B.3'UTR.nos+2.Scer\UAS cephalopharyngeal skeleton nosΔTCE+HDE nosΔTCE.nos cephalopharyngeal skeleton | embryonic stage | maternal effect nosΔEX class IV dendritic arborizing neuron | late third instar larval stage (with Df(3R)Dl-X43) nos18 class IV dendritic arborizing neuron | late third instar larval stage (with nos18) nos53 class IV dendritic arborizing neuron | late third instar larval stage (with nos53) nos18 class IV dendritic arborizing neuron | third instar larval stage nosαTub84B.UTR.T:Ivir\HA1 nosgnosGRH- nosgnosSREs- nosgnosSREs-.GRH- cystoblast & plasma membrane nos18 nos53 cystocyte nos18 cystocyte & plasma membrane nos18 nos53 dendritic arborising neuron & dendrite | somatic clone nos18 dendritic arborising neuron & dendritic tree, with Scer\GAL48-123 nosαTub84B.3'UTR.Scer\UAS nosαTub84B.3'UTR.nos+2.Scer\UAS dendritic arborising neuron & dendritic tree, with Scer\GAL4109(2)80 nosαTub84B.3'UTR.Scer\UAS dendritic arborising neuron & dendritic tree, with Scer\GAL4477 nosαTub84B.3'UTR.Scer\UAS dorsal bridge nosΔTCE+HDE nosΔTCE.nos dorsal closure embryo nosBN egg nos18 egg chamber nos18 egg chamber (with nos18) nos53 egg chamber (with nos53) nos18 embryo | anterior nosTCE.IIIA nosTCE.IIIA.Tloop nosTCE.IIIA:U nosTCE.IIIGC nosTCE.IIIGC:GC nosTCE.IIIU nosTCEIIA nosTCEIIU nosbcd.3UTR nosnos.+2'A-3X.T:Ivir\HA1 nosnos.+2'B-3X.T:Ivir\HA1 nosnos.+2'C-3X.T:Ivir\HA1 nosnos.+2'D-3X.T:Ivir\HA1 embryo | ectopic | posterior nosbcd.3UTR embryonic/first instar larval cuticle nosL7 embryonic abdominal segment nosBN nosL7 embryonic abdominal segment 1 nosL7 nosunspecified embryonic abdominal segment 2 nosL7 nosunspecified embryonic abdominal segment 3 nosL7 nosunspecified embryonic abdominal segment 4 nosL7 nosunspecified embryonic abdominal segment 5 nosL7 nosunspecified embryonic abdominal segment 6 nosL7 nosunspecified embryonic abdominal segment 7 nosL7 nosunspecified embryonic abdominal segment 8 nosL7 nosunspecified embryonic abdominal segment 9 nosL7 nosunspecified embryonic abdominal segment 10 nosL7 nosunspecified embryonic abdominal segment 11 nosL7 nosunspecified embryonic abdominal segment, with nosBN nosΔBX embryonic abdominal segment, with nosΔBX nosBN embryonic epidermis nosΔBE nosΔBX nosΔEE nosΔEX nosΔX.αTub84B nos3xSRE+ nosTCE.bcdUTR nosb.n.21-80.A27U.T:Ivir\HA1 nosb.n.21-80.A37U.T:Ivir\HA1 nosb.n.21-80.C32G.T:Ivir\HA1 nosb.n.21-80.G28C.T:Ivir\HA1 nosb.n.21-80.G34C.T:Ivir\HA1 nosb.n.21-80.G38C.T:Ivir\HA1 nosb.n.21-80.U41A.T:Ivir\HA1 nosb.n.21-80.U42C.T:Ivir\HA1 embryonic epidermis | maternal effect nos3xSRE- nosb.n.1-16 nosb.n.1-32 nosb.n.1-48 nosb.n.1-64 nosb.n.41-96 nosb.n.61-96 nosb.n.96-1 nosb.n.96-1.T:Ivir\HA1 nosb.n.T:Ivir\HA1 nosbcd.3UTR.D nosbcdUTR.nos embryonic head nosαTub84B.UTR.T:Ivir\HA1 nosTCE.A15G nosTCE.G12U nosb.n.1-80 nosb.n.1-96 nosb.n.1-96.T:Ivir\HA1 nosb.n.21-80.T:Ivir\HA1 nosb.n.21-96 embryonic head | maternal effect nosΔTCE nosαTub84B.UTR.T:Ivir\HA1 nosSRE1.SRE2 nosTCE2 nosTCE7 nosTCE8 nosbcd.3UTR embryonic thoracic segment nosαTub84B.UTR.T:Ivir\HA1 embryonic thoracic segment | maternal effect nosαTub84B.UTR.T:Ivir\HA1 embryonic thorax | anterior nosbcd.3UTR extended germ band embryo nosL7 eye nosGMR.PW female germline stem cell nos18 nos53 female germline stem cell & plasma membrane nos18 nos53 female germline stem cell | somatic clone nos18 nos53 filzkorper | maternal effect nosbcd.3UTR fusome nos18 germarium nos18 nos53 germarium | anterior nos18 germline cell nos18 nosBN nosL7 germline cyst (with nos18) nos53 germline cyst (with nos53) nos18 germline cyst | ectopic (with Df(3R)Dl-FX3) nos18 germline stem cell (with Df(3R)nos) nos18 nos53 gonad | larval stage (with Df(3R)Dl-FX3) nos18 Kenyon cell, with Scer\GAL47B nosUY4741 Kenyon cell, with Scer\GAL4ey-OK107 nosαTub84B.3'UTR.Scer\UAS nosUY4741 mesothoracic ventral denticle belt | maternal effect nosbcd.3UTR metathoracic ventral denticle belt | maternal effect nosbcd.3UTR mitochondrion nos18 nos53 mushroom body & axon, with Scer\GAL47B nosUY4741 mushroom body & axon, with Scer\GAL4ey-OK107 nosαTub84B.3'UTR.Scer\UAS nosUY4741 ommatidium, with Scer\GAL4GMR.PF nosαTub84B.3'UTR.Scer\UAS nosαTub84B.3'UTR.nos+2.Scer\UAS ommatidium, with Scer\GAL4hs.2sev nosαTub84B.3'UTR.Scer\UAS nosαTub84B.3'UTR.nos+2.Scer\UAS ovariole nos18 nos53 ovariole (with nos18) nos53 ovariole (with nos53) nos18 ovary nos18 ovary (with Df(3R)nos) nos18 nos53 pole cell nosBN pole cell | maternal effect nosBN prothoracic ventral denticle belt | maternal effect nosbcd.3UTR spectrosome nos18 telson nos18 nos53 testis nos18 nos53 vertical bridge nosΔTCE+HDE wing, with Scer\GAL4Eh.2.4 nosαTub84B.3'UTR.Scer\UAS nosαTub84B.3'UTR.nos+2.Scer\UAS wing, with Scer\GAL4HD23A nosαTub84B.3'UTR.Scer\UAS nosαTub84B.3'UTR.nos+2.Scer\UAS wing, with Scer\GAL4HD44A nosαTub84B.3'UTR.Scer\UAS nosαTub84B.3'UTR.nos+2.Scer\UAS wing, with Scer\GAL4hs.2sev nosαTub84B.3'UTR.Scer\UAS nosαTub84B.3'UTR.nos+2.Scer\UAS wing, with Scer\GAL4KF42A nosαTub84B.3'UTR.Scer\UAS wing, with Scer\GAL4sca-109-68 nosαTub84B.3'UTR.Scer\UAS nosαTub84B.3'UTR.nos+2.Scer\UAS
Classical Alleles ( 25 )
For All Classical Alleles Show
Allele of nos Class Mutagen Stocks Known lesion nosL7 loss of function allele, hypomorphic allele - genetic evidence ethyl methanesulfonate 8 Yes nosj3B6 P-element activity 2 -- nos01 1 Yes nosc01494 piggyBac transposase 1 -- nosCB-6897-3 1 -- nosEY01331 P-element activity 1 Yes nosNP4727 1 -- nosNP5363 1 -- nosUY4741 P-element activity 1 Yes nos18 amorphic allele - genetic evidence, loss of function allele ethyl methanesulfonate 0 Yes nos01536 P-element activity 0 -- nos05678 P-element activity 0 -- nos07117 P-element activity 0 -- nos17 0 Yes nos53 loss of function allele ethyl methanesulfonate 0 Yes nosBN loss of function allele P-element activity 0 Yes nosBNX2.1 0 Yes nosEY00281 0 -- nosGS5240 0 Yes nosj4B6 P-element activity 0 -- nosM82 ethyl methanesulfonate 0 -- nosNP4407 0 -- nosP51 ethyl methanesulfonate 0 -- nosScim Delta2-3 0 Yes nosunspecified 0 --
Alleles Carried on Transgenic Constructs ( 244 )
For All Alleles Carried on Transgenic Constructs Show
Allele of nos Class Mutagen Stocks Known lesion nosGD11715 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes nosHMS00785 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes nosHMS00930 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes nosJF02931 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes nos+1+3.T:MS2\MCP.BS in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes nos+1.18.T:MS2\MCP.BS in vitro construct - deletion in vitro construct 0 Yes nos+2.18.T:MS2\MCP.BS in vitro construct - deletion in vitro construct 0 Yes nos+4.4.T:Ivir\HA1 in vitro construct - coding region fusion 0 Yes nos+mSa in vitro construct - minigene 0 Yes nos+t5.7 in vitro construct - genomic fragment 0 Yes nos108.αTub84B.UTR.T:Ivir\HA1 wild-type allele ethyl methanesulfonate 0 Yes nos111.αTub84B.UTR.T:Ivir\HA1 ethyl methanesulfonate 0 Yes nos122.αTub84B.UTR.T:Ivir\HA1 ethyl methanesulfonate 0 Yes nos139.αTub84B.UTR.T:Ivir\HA1 ethyl methanesulfonate 0 Yes nos153.αTub84B.UTR.T:Ivir\HA1 ethyl methanesulfonate 0 Yes nos154.αTub84B.UTR.T:Ivir\HA1 ethyl methanesulfonate 0 Yes nos165.αTub84B.UTR.T:Ivir\HA1 ethyl methanesulfonate 0 Yes nos18.T:MS2\MCP.BS in vitro construct 0 Yes nos18.αTub84B.UTR.T:Ivir\HA1 ethyl methanesulfonate 0 Yes nos183.αTub84B.UTR.T:Ivir\HA1 ethyl methanesulfonate 0 Yes nos19.αTub84B.UTR.T:Ivir\HA1 ethyl methanesulfonate 0 Yes nos197.αTub84B.UTR.T:Ivir\HA1 ethyl methanesulfonate 0 Yes nos204.αTub84B.UTR.T:Ivir\HA1 ethyl methanesulfonate 0 Yes nos212.αTub84B.UTR.T:Ivir\HA1 ethyl methanesulfonate 0 Yes nos2173 in vitro construct - regulatory fusion 0 Yes nos243.αTub84B.UTR.T:Ivir\HA1 ethyl methanesulfonate 0 Yes nos246.αTub84B.UTR.T:Ivir\HA1 ethyl methanesulfonate 0 Yes nos253.αTub84B.UTR.T:Ivir\HA1 ethyl methanesulfonate 0 Yes nos254.αTub84B.UTR.T:Ivir\HA1 ethyl methanesulfonate 0 Yes nos258.αTub84B.UTR.T:Ivir\HA1 ethyl methanesulfonate 0 Yes nos263.αTub84B.UTR.T:Ivir\HA1 ethyl methanesulfonate 0 Yes nos264.αTub84B.UTR.T:Ivir\HA1 ethyl methanesulfonate 0 Yes nos272.αTub84B.UTR.T:Ivir\HA1 ethyl methanesulfonate 0 Yes nos273.αTub84B.UTR.T:Ivir\HA1 ethyl methanesulfonate 0 Yes nos277.αTub84B.UTR.T:Ivir\HA1 ethyl methanesulfonate 0 Yes nos286.αTub84B.UTR.T:Ivir\HA1 ethyl methanesulfonate 0 Yes nos295.αTub84B.UTR.T:Ivir\HA1 wild-type allele ethyl methanesulfonate 0 Yes nos3.αTub84B.UTR.T:Ivir\HA1 wild-type allele ethyl methanesulfonate 0 Yes nos3xSRE+ in vitro construct - regulatory fusion 0 Yes nos3xSRE- in vitro construct - site directed mutagenesis 0 Yes nos4CF1 in vitro construct - site directed mutagenesis in vitro construct - amino acid replacement 0 Yes nos4CF2 in vitro construct - site directed mutagenesis in vitro construct - amino acid replacement 0 Yes nos505.αTub84B.UTR.T:Ivir\HA1 ethyl methanesulfonate 0 Yes nos506.αTub84B.UTR.T:Ivir\HA1 ethyl methanesulfonate 0 Yes nos512.αTub84B.UTR.T:Ivir\HA1 ethyl methanesulfonate 0 Yes nos516.αTub84B.UTR.T:Ivir\HA1 ethyl methanesulfonate 0 Yes nos517.αTub84B.UTR.T:Ivir\HA1 ethyl methanesulfonate 0 Yes nos520.αTub84B.UTR.T:Ivir\HA1 ethyl methanesulfonate 0 Yes nos524.αTub84B.UTR.T:Ivir\HA1 ethyl methanesulfonate 0 Yes nos526.αTub84B.UTR.T:Ivir\HA1 ethyl methanesulfonate 0 Yes nos538.αTub84B.UTR.T:Ivir\HA1 ethyl methanesulfonate 0 Yes nos539.αTub84B.UTR.T:Ivir\HA1 ethyl methanesulfonate 0 Yes nos549.αTub84B.UTR.T:Ivir\HA1 ethyl methanesulfonate 0 Yes nos554.αTub84B.UTR.T:Ivir\HA1 ethyl methanesulfonate 0 Yes nos558.αTub84B.UTR.T:Ivir\HA1 ethyl methanesulfonate 0 Yes nos560.αTub84B.UTR.T:Ivir\HA1 ethyl methanesulfonate 0 Yes nos565.αTub84B.UTR.T:Ivir\HA1 ethyl methanesulfonate 0 Yes nos568.αTub84B.UTR.T:Ivir\HA1 ethyl methanesulfonate 0 Yes nos579.αTub84B.UTR.T:Ivir\HA1 ethyl methanesulfonate 0 Yes nos581.αTub84B.UTR.T:Ivir\HA1 ethyl methanesulfonate 0 Yes nos585.αTub84B.UTR.T:Ivir\HA1 ethyl methanesulfonate 0 Yes nos587.αTub84B.UTR.T:Ivir\HA1 ethyl methanesulfonate 0 Yes nos592.αTub84B.UTR.T:Ivir\HA1 ethyl methanesulfonate 0 Yes nos594.αTub84B.UTR.T:Ivir\HA1 ethyl methanesulfonate 0 Yes nos595.αTub84B.UTR.T:Ivir\HA1 ethyl methanesulfonate 0 Yes nos599.αTub84B.UTR.T:Ivir\HA1 ethyl methanesulfonate 0 Yes nos6.T:MS2\MCP.BS in vitro construct 0 Yes nos6.αTub84B.UTR.T:Ivir\HA1 ethyl methanesulfonate 0 Yes nos607.αTub84B.UTR.T:Ivir\HA1 ethyl methanesulfonate 0 Yes nos614.αTub84B.UTR.T:Ivir\HA1 ethyl methanesulfonate 0 Yes nos620.αTub84B.UTR.T:Ivir\HA1 ethyl methanesulfonate 0 Yes nos623.αTub84B.UTR.T:Ivir\HA1 ethyl methanesulfonate 0 Yes nos626.αTub84B.UTR.T:Ivir\HA1 ethyl methanesulfonate 0 Yes nos627.αTub84B.UTR.T:Ivir\HA1 ethyl methanesulfonate 0 Yes nos635.αTub84B.UTR.T:Ivir\HA1 ethyl methanesulfonate 0 Yes nos641.αTub84B.UTR.T:Ivir\HA1 ethyl methanesulfonate 0 Yes nos672.αTub84B.UTR.T:Ivir\HA1 ethyl methanesulfonate 0 Yes nosb.n.1-16 in vitro construct - regulatory fusion 0 Yes nosb.n.1-32 in vitro construct - regulatory fusion 0 Yes nosb.n.1-48 in vitro construct - regulatory fusion 0 Yes nosb.n.1-64 in vitro construct - regulatory fusion 0 Yes nosb.n.1-80 in vitro construct - regulatory fusion 0 Yes nosb.n.1-96.T:Ivir\HA1 in vitro construct - regulatory fusion 0 Yes nosb.n.1-96 in vitro construct - regulatory fusion 0 Yes nosb.n.21-80.A27U.T:Ivir\HA1 in vitro construct - site directed mutagenesis 0 Yes nosb.n.21-80.A37U.T:Ivir\HA1 in vitro construct - site directed mutagenesis 0 Yes nosb.n.21-80.C32G.T:Ivir\HA1 in vitro construct - site directed mutagenesis 0 Yes nosb.n.21-80.G28C.T:Ivir\HA1 in vitro construct - site directed mutagenesis 0 Yes nosb.n.21-80.G34C.T:Ivir\HA1 in vitro construct - site directed mutagenesis 0 Yes nosb.n.21-80.G38C.T:Ivir\HA1 in vitro construct - site directed mutagenesis 0 Yes nosb.n.21-80.T:Ivir\HA1 in vitro construct - regulatory fusion 0 Yes nosb.n.21-80.U41A.T:Ivir\HA1 in vitro construct - site directed mutagenesis 0 Yes nosb.n.21-80.U42C.T:Ivir\HA1 in vitro construct - site directed mutagenesis 0 Yes nosb.n.21-96 in vitro construct - regulatory fusion 0 Yes nosb.n.41-96 in vitro construct - regulatory fusion 0 Yes nosb.n.61-96 in vitro construct - regulatory fusion 0 Yes nosb.n.96-1.T:Ivir\HA1 in vitro construct - regulatory fusion 0 Yes nosb.n.96-1 in vitro construct - regulatory fusion 0 Yes nosb.n.T:Ivir\HA1 in vitro construct - coding region fusion 0 Yes nosbam.3'UTR.T:Avic\GFP-EGFP in vitro construct 0 -- nosbcd.3UTR.D in vitro construct - regulatory fusion 0 Yes nosbcd.3UTR in vitro construct - regulatory fusion 0 Yes nosbcd.nos.UTR in vitro construct - regulatory fusion 0 Yes nosbcdUTR.nos in vitro construct - regulatory fusion 0 Yes nosC.T:MS2\MCP in vitro construct - coding region fusion 0 Yes nosC319Y,C354Y in vitro construct - amino acid replacement 0 Yes nosC319Y in vitro construct - amino acid replacement 0 Yes nosC354Y in vitro construct - amino acid replacement 0 Yes noscBa in vitro construct 0 -- nosfl.cCa in vitro construct 0 -- nosfs in vitro construct 0 Yes nosGMR.PW in vitro construct - regulatory fusion 0 Yes nosgnosb in vitro construct - genomic fragment 0 Yes nosgnosGRH- in vitro construct 0 Yes nosgnosSREs-.GRH- in vitro construct 0 Yes nosgnosSREs- in vitro construct 0 Yes noshs.PW in vitro construct - regulatory fusion 0 Yes nosKK105687 in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes nosL7.cAa in vitro construct 0 Yes nosM.T:MS2\MCP in vitro construct - coding region fusion 0 Yes nosN.T:MS2\MCP in vitro construct - coding region fusion 0 Yes nosN5 in vitro construct - minigene 0 Yes nosnos.+1.+2' in vitro construct 0 Yes nosnos.+1.Hsp83 in vitro construct - deletion 0 Yes nosnos.+10.Hsp83 in vitro construct - deletion 0 Yes nosnos.+2'-2X.T:Ivir\HA1 in vitro construct - regulatory fusion 0 Yes nosnos.+2'-3X.T:Ivir\HA1 in vitro construct - regulatory fusion 0 Yes nosnos.+2'.Hsp83 in vitro construct - deletion 0 Yes nosnos.+2'A-3X.T:Ivir\HA1 in vitro construct 0 Yes nosnos.+2'B-3X.T:Ivir\HA1 in vitro construct 0 Yes nosnos.+2'C-3X.T:Ivir\HA1 in vitro construct 0 Yes nosnos.+2'D-3X.T:Ivir\HA1 in vitro construct 0 Yes nosnos.+2'E-3X.T:Ivir\HA1 in vitro construct 0 Yes nosnos.+2'F-3X.T:Ivir\HA1 in vitro construct 0 Yes nosnos.+2'ME-3X.T:Ivir\HA1 in vitro construct 0 Yes nosnos.+2(A)G:C in vitro construct 0 Yes nosnos.+2(D)G:C in vitro construct 0 Yes nosnos.+2,3.Hsp83 in vitro construct - deletion 0 Yes nosnos.+2-2X.T:Ivir\HA1 in vitro construct - regulatory fusion 0 Yes nosnos.+2-3X.T:Ivir\HA1 in vitro construct - regulatory fusion 0 Yes nosnos.+2.Hsp83 in vitro construct - deletion 0 Yes nosnos.+2.IIA:U+U51A in vitro construct 0 Yes nosnos.+2.IIA:U in vitro construct 0 Yes nosnos.+2.U51A in vitro construct 0 Yes nosnos.+2A.T:Ivir\HA1 in vitro construct 0 Yes nosnos.+2C.T:Ivir\HA1 in vitro construct 0 Yes nosnos.+2E.T:Ivir\HA1 in vitro construct 0 Yes nosnos.+2RO.T:Ivir\HA1 in vitro construct 0 Yes nosnos.+3-2X.T:Ivir\HA1 in vitro construct - regulatory fusion 0 Yes nosnos.+3-3X.T:Ivir\HA1 in vitro construct - regulatory fusion 0 Yes nosnos.+3.Hsp83 in vitro construct - deletion 0 Yes nosnos.+4-2X.T:Ivir\HA1 in vitro construct - regulatory fusion 0 Yes nosnos.+4-3X.T:Ivir\HA1 in vitro construct - regulatory fusion 0 Yes nosnos.+4.Hsp83 in vitro construct - deletion 0 Yes nosnos.+6.Hsp83 in vitro construct - deletion 0 Yes nosnos.+9.Hsp83 in vitro construct - deletion 0 Yes nosnos.IIA:U+U51A in vitro construct 0 Yes nososk.UTR in vitro construct - regulatory fusion 0 Yes nosRC.T:Hsap\MYC in vitro construct - coding region fusion 0 Yes nosSRE1.SRE2 in vitro construct - site directed mutagenesis 0 Yes nosT:Avic\GFP-EGFP in vitro construct - coding region fusion 0 Yes nosT:Hsap\MYC in vitro construct - coding region fusion 0 Yes nosTCE+ in vitro construct 0 Yes nosTCE.A15G in vitro construct - site directed mutagenesis 0 Yes nosTCE.bcdUTR in vitro construct - regulatory fusion 0 Yes nosTCE.G12U in vitro construct - site directed mutagenesis 0 Yes nosTCE.II^III.T:Ivir\HA1 in vitro construct - regulatory fusion 0 Yes nosTCE.IIIA.Tloop in vitro construct 0 Yes nosTCE.IIIA:U.Tloop in vitro construct 0 Yes nosTCE.IIIA:U in vitro construct - site directed mutagenesis 0 Yes nosTCE.IIIA:U^C72 in vitro construct 0 Yes nosTCE.IIIA in vitro construct - site directed mutagenesis 0 Yes nosTCE.IIIGC:GC in vitro construct - site directed mutagenesis 0 Yes nosTCE.IIIGC in vitro construct - site directed mutagenesis 0 Yes nosTCE.IIIU in vitro construct - site directed mutagenesis 0 Yes nosTCE.SRE- in vitro construct - site directed mutagenesis 0 Yes nosTCE.U18C in vitro construct - site directed mutagenesis 0 Yes nosTCE.ΔProxIII in vitro construct - deletion 0 Yes nosTCE1 in vitro construct 0 Yes nosTCE2 in vitro construct 0 Yes nosTCE3 in vitro construct 0 Yes nosTCE4 in vitro construct 0 Yes nosTCE5 in vitro construct 0 Yes nosTCE6 in vitro construct 0 Yes nosTCE7 in vitro construct 0 Yes nosTCE8 in vitro construct 0 Yes nosTCE9 in vitro construct 0 Yes nosTCEIIA.U in vitro construct - site directed mutagenesis 0 Yes nosTCEIIA in vitro construct - site directed mutagenesis 0 Yes nosTCEIII.TLoop in vitro construct - site directed mutagenesis 0 Yes nosTCEIII.U51A in vitro construct - site directed mutagenesis 0 Yes nosTCEIIU in vitro construct - site directed mutagenesis 0 Yes nosTCEIIUC.AG in vitro construct 0 Yes nostub3'UTR.Scer\UAS.T:Ivir\HA1 in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes nosvir3'UTR in vitro construct - regulatory fusion 0 Yes nosαTub84B.3'UTR.Brd.Scer\UAS in vitro construct - regulatory fusion 0 Yes nosαTub84B.3'UTR.nos+2.Scer\UAS in vitro construct - regulatory fusion 0 Yes nosαTub84B.3'UTR.nosB1m.TCEIIU.B3m1.Scer\UAS in vitro construct - site directed mutagenesis 0 Yes nosαTub84B.3'UTR.nosB3m1.Scer\UAS in vitro construct - regulatory fusion in vitro construct - site directed mutagenesis 0 Yes nosαTub84B.3'UTR.nosB3m2.Scer\UAS in vitro construct - regulatory fusion in vitro construct - site directed mutagenesis 0 Yes nosαTub84B.3'UTR.nosNR.Scer\UAS in vitro construct - regulatory fusion 0 Yes nosαTub84B.3'UTR.nosSRE.Scer\UAS in vitro construct - regulatory fusion in vitro construct - site directed mutagenesis 0 Yes nosαTub84B.3'UTR.nosTCE.Scer\UAS in vitro construct - regulatory fusion 0 Yes nosαTub84B.3'UTR.nosTCEIIA.IIIA.Scer\UAS in vitro construct - regulatory fusion in vitro construct - site directed mutagenesis 0 Yes nosαTub84B.3'UTR.nosTCEIIA.Scer\UAS in vitro construct - regulatory fusion in vitro construct - site directed mutagenesis 0 Yes nosαTub84B.3'UTR.nosTCEIIIA.Scer\UAS in vitro construct - regulatory fusion in vitro construct - site directed mutagenesis 0 Yes nosαTub84B.3'UTR.nosTCEIIU.B3m1.Scer\UAS in vitro construct - regulatory fusion in vitro construct - site directed mutagenesis 0 Yes nosαTub84B.3'UTR.nosTCEIIU.Scer\UAS in vitro construct - regulatory fusion in vitro construct - site directed mutagenesis 0 Yes nosαTub84B.3'UTR.pho.Scer\UAS in vitro construct - regulatory fusion 0 Yes nosαTub84B.3'UTR.Scer\UAS in vitro construct - regulatory fusion 0 Yes nosαTub84B.3'UTR.T:Avic\GFP-EGFP in vitro construct 0 Yes nosαTub84B.UTR.T:Ivir\HA1 in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes nosαTub84B.UTR.virTCE.T:Ivir\HA1 in vitro construct - regulatory fusion 0 Yes nosΔ10 in vitro construct - deletion 0 Yes nosΔ2-287 in vitro construct - deletion 0 Yes nosΔ2-301 in vitro construct - deletion 0 Yes nosΔ2-314 in vitro construct - deletion 0 Yes nosΔ218-287 in vitro construct - deletion 0 Yes nosΔ288-314 in vitro construct - deletion 0 Yes nosΔ50-218 in vitro construct - deletion 0 Yes nosΔA in vitro construct - deletion 0 Yes nosΔB.αTub84B.3'UTR.nos+2.Scer\UAS in vitro construct 0 Yes nosΔB.αTub84B.3'UTR.Scer\UAS in vitro construct 0 Yes nosΔB in vitro construct - deletion 0 Yes nosΔBE in vitro construct - deletion 0 Yes nosΔBX-tetra2 in vitro construct - site directed mutagenesis 0 Yes nosΔBX in vitro construct - deletion 0 Yes nosΔC in vitro construct - deletion 0 Yes nosΔD in vitro construct - deletion 0 Yes nosΔE in vitro construct - deletion 0 Yes nosΔEE in vitro construct - deletion 0 Yes nosΔEX in vitro construct - deletion 0 Yes nosΔF in vitro construct - deletion 0 Yes nosΔG in vitro construct - deletion 0 Yes nosΔLS.18.T:MS2\MCP.BS in vitro construct - deletion in vitro construct 0 Yes nosΔpi412 in vitro construct - deletion 0 Yes nosΔpiroo-Δpi412 in vitro construct - deletion 0 Yes nosΔpiroo in vitro construct - deletion 0 Yes nosΔTCE+HDE in vitro construct - regulatory fusion 0 Yes nosΔTCE-A in vitro construct - deletion 0 Yes nosΔTCE-B in vitro construct - deletion 0 Yes nosΔTCE.nos in vitro construct 0 Yes nosΔTCE in vitro construct - deletion 0 Yes nosΔX.αTub84B in vitro construct 0 Yes
Aneuploid Aberrations
Disrupted in	Df(3R)Dl-A143 (Wang and Lehmann, 1991) Df(3R)Dl-BX12 (Spradling et al., 1999, BDGP Project Members, 1994-1999) Df(3R)Dl-FX3 (Forbes and Lehmann, 1998, Bhat, 1999) Df(3R)Dl-X43 (Curtis et al., 1995) Df(3R)ED5911 (Ryder and Roote, 2004.11.10) Df(3R)Exel6183 (Ryder, 2004.4.26) Df(3R)nos (Li et al., 2009)
Not disrupted in	Df(3R)Cha7 (Spradling et al., 1999, BDGP Project Members, 1994-1999) Df(3R)Dl-HD28 (Wang and Lehmann, 1991) In(3LR)Dl-KX12 (Wang and Lehmann, 1991)
Transgenic Constructs & Insertions
Transgenic Constructs
UAS construct	Name Expression Data P{GD11715} NA P{KK105687} NA P{TRiP.HMS00785} NA P{TRiP.HMS00930} NA P{TRiP.JF02931} NA P{UAS-HA-nos-tub3'UTR} NA P{UAS-nos-tub3'UTR} NA P{UAS-nos-tub:B1m.TCEIIU.B3m1} NA P{UAS-nos-tub:B3m1} NA P{UAS-nos-tub:B3m2} NA P{UAS-nos-tub:Brd} NA P{UAS-nos-tub:nos+2} NA P{UAS-nos-tub:NR} NA P{UAS-nos-tub:pho} NA P{UAS-nos-tub:SRE} NA P{UAS-nos-tub:TCE} NA P{UAS-nos-tub:TCEIIA.IIIA} NA P{UAS-nos-tub:TCEIIA} NA P{UAS-nos-tub:TCEIIU.B3m1} NA P{UAS-nos-tub:TCEIIU} NA P{UAS-nosΔB-tub3'UTR} NA P{UAS-nosΔB-tub:nos+2} NA
heat-shock construct	Name Expression Data P{hs-nos.W} NA P{nos-tub:nos+1} NA P{nos-tub:nos+2,3} NA P{nos-tub:nos+2'} NA P{nos-tub:nos+2} NA P{nos-tub:nos+3} NA P{nos-tub:nos+4} NA P{nos-tub:nos+6} NA P{nos-tub:nos+9} NA P{nos-tub:nos+10} NA
reporter construct	Name Expression Data P{lacZ-nos3'UTR} No P{lacZ-nos+2'} No P{lacZ-nos+3} No P{lacZ-nos+4} No P{lacZ-nos+9} No P{lacZ-nos+10} No P{lacZ-nosΔ1} No P{lacZ-nosΔ2} No P{lacZ-nosΔ3} No P{lacZ-nosΔ4} No P{lacZ-nosΔ6} No P{lacZ-nosΔ7} No P{lacZ-nosΔ8} No P{lacZ-nosΔ9} No P{lacZ-nosΔ10} No
characterization construct	Name Expression Data M{nos-int.B} NA M{nos-int.NLS} NA P{1-16} NA P{1-32} NA P{1-48} NA P{1-64} NA P{1-80} NA P{1-96} NA P{3xSRE+} NA P{3xSRE-} NA P{21-96} NA P{41-96} NA P{61-96} NA P{96-1} NA P{2173} NA P{Dmnos} NA P{GMR-nos.W} NA P{gnosb} NA P{gnosGRH-} NA P{gnosSREs-} NA P{gnosSREs-GRH-} NA P{HA/1-96} NA P{HA/21-80} NA P{HA/96-1} NA P{HA/A27U} NA P{HA/A37U} NA P{HA/C32G} NA P{HA/G28C} NA P{HA/G34C} NA P{HA/G38C} NA P{HA/U41A} NA P{HA/U42C} NA P{mel-vir3'UTR} NA P{nos/bcd} NA P{nos-(ms2).6} NA P{nos-(ms2).18} NA P{nos(ΔBE)} NA P{nos(ΔBX,tetra2)} NA P{nos(ΔBX)} NA P{nos(ΔEE)} NA P{nos(ΔEX)} NA P{nos(ΔTCE)} NA P{nos(ΔTCE-A)} NA P{nos(ΔTCE-B)} NA P{nos(ΔX+αTub84B)} NA P{nos} NA P{nos+1-(ms2).18} NA P{nos+1+3} NA P{nos+2-(ms2).18} NA P{nos3.αTub84B.UTR.T:Ivir\HA1} NA P{nos6.αTub84B.UTR.T:Ivir\HA1} NA P{nos19.αTub84B.UTR.T:Ivir\HA1} NA P{nos108.αTub84B.UTR.T:Ivir\HA1} NA P{nos111.αTub84B.UTR.T:Ivir\HA1} NA P{nos122.αTub84B.UTR.T:Ivir\HA1} NA P{nos139.αTub84B.UTR.T:Ivir\HA1} NA P{nos153.αTub84B.UTR.T:Ivir\HA1} NA P{nos154.αTub84B.UTR.T:Ivir\HA1} NA P{nos165.αTub84B.UTR.T:Ivir\HA1} NA P{nos183.αTub84B.UTR.T:Ivir\HA1} NA P{nos197.αTub84B.UTR.T:Ivir\HA1} NA P{nos204.αTub84B.UTR.T:Ivir\HA1} NA P{nos212.αTub84B.UTR.T:Ivir\HA1} NA P{nos243.αTub84B.UTR.T:Ivir\HA1} NA P{nos246.αTub84B.UTR.T:Ivir\HA1} NA P{nos253.αTub84B.UTR.T:Ivir\HA1} NA P{nos254.αTub84B.UTR.T:Ivir\HA1} NA P{nos258.αTub84B.UTR.T:Ivir\HA1} NA P{nos263.αTub84B.UTR.T:Ivir\HA1} NA P{nos264.αTub84B.UTR.T:Ivir\HA1} NA P{nos272.αTub84B.UTR.T:Ivir\HA1} NA P{nos273.αTub84B.UTR.T:Ivir\HA1} NA P{nos277.αTub84B.UTR.T:Ivir\HA1} NA P{nos286.αTub84B.UTR.T:Ivir\HA1} NA P{nos295.αTub84B.UTR.T:Ivir\HA1} NA P{nos505.αTub84B.UTR.T:Ivir\HA1} NA P{nos506.αTub84B.UTR.T:Ivir\HA1} NA P{nos512.αTub84B.UTR.T:Ivir\HA1} NA P{nos516.αTub84B.UTR.T:Ivir\HA1} NA P{nos517.αTub84B.UTR.T:Ivir\HA1} NA P{nos520.αTub84B.UTR.T:Ivir\HA1} NA P{nos524.αTub84B.UTR.T:Ivir\HA1} NA P{nos526.αTub84B.UTR.T:Ivir\HA1} NA P{nos538.αTub84B.UTR.T:Ivir\HA1} NA P{nos539.αTub84B.UTR.T:Ivir\HA1} NA P{nos549.αTub84B.UTR.T:Ivir\HA1} NA P{nos554.αTub84B.UTR.T:Ivir\HA1} NA P{nos558.αTub84B.UTR.T:Ivir\HA1} NA P{nos560.αTub84B.UTR.T:Ivir\HA1} NA P{nos565.αTub84B.UTR.T:Ivir\HA1} NA P{nos568.αTub84B.UTR.T:Ivir\HA1} NA P{nos579.αTub84B.UTR.T:Ivir\HA1} NA P{nos581.αTub84B.UTR.T:Ivir\HA1} NA P{nos585.αTub84B.UTR.T:Ivir\HA1} NA P{nos587.αTub84B.UTR.T:Ivir\HA1} NA P{nos592.αTub84B.UTR.T:Ivir\HA1} NA P{nos594.αTub84B.UTR.T:Ivir\HA1} NA P{nos595.αTub84B.UTR.T:Ivir\HA1} NA P{nos599.αTub84B.UTR.T:Ivir\HA1} NA P{nos607.αTub84B.UTR.T:Ivir\HA1} NA P{nos614.αTub84B.UTR.T:Ivir\HA1} NA P{nos620.αTub84B.UTR.T:Ivir\HA1} NA P{nos623.αTub84B.UTR.T:Ivir\HA1} NA P{nos626.αTub84B.UTR.T:Ivir\HA1} NA P{nos627.αTub84B.UTR.T:Ivir\HA1} NA P{nos635.αTub84B.UTR.T:Ivir\HA1} NA P{nos641.αTub84B.UTR.T:Ivir\HA1} NA P{nos672.αTub84B.UTR.T:Ivir\HA1} NA P{nos+} NA P{nosA18.αTub84B.UTR.T:Ivir\HA1} NA P{nosbam.3'UTR.T:Avic\GFP-EGFP} NA P{nosnos.+2-2X.T:Ivir\HA1} NA P{nosnos.+2-3X.T:Ivir\HA1} NA P{nosnos.+2'-2X.T:Ivir\HA1} NA P{nosnos.+2'-3X.T:Ivir\HA1} NA P{nosnos.+3-2X.T:Ivir\HA1} NA P{nosnos.+3-3X.T:Ivir\HA1} NA P{nosnos.+4-2X.T:Ivir\HA1} NA P{nosnos.+4-3X.T:Ivir\HA1} NA P{nosT:Avic\GFP-EGFP} NA P{nosTCE.A15G} NA P{nosTCE.G12U} NA P{nosTCE.U18C} NA P{nosTCE+} NA P{nosΔA} NA P{nosΔB} NA P{nosΔC} NA P{nosΔD} NA P{nosΔE} NA P{nosΔF} NA P{nosΔG} NA P{nosΔTCE.nos} NA P{nosΔTCE+HDE} NA P{nosαTub84B.3'UTR.T:Avic\GFP-EGFP} NA P{nos-bam-GFP} NA P{nos-bcd3'UTR} NA P{nos-bcd/nos3'UTR} NA P{nos-bcd} NA P{nos-CP.C} NA P{nos-CP.M} NA P{nos-CP.N} NA P{nosHA/bcd} NA P{nos-myc.RC} NA P{nos-myc.V} NA P{nos-osk3'UTR} NA P{nos-phiC31\int.NLS} NA P{nosSRE-} NA P{nos-TCE-bcd} NA P{nos-tub3'UTR.w} NA P{nos-tub3'UTR} NA P{nos-tub:nos+2.IIA/U} NA P{nos-tub:nos+2.IIA/U+U51A} NA P{nos-tub:nos+2.U51A} NA P{nos-tub:nos+2'(A)-3X} NA P{nos-tub:nos+2'(B)-3X} NA P{nos-tub:nos+2'(C)-3X} NA P{nos-tub:nos+2'(D)-3X} NA P{nos-tub:nos+2'(E)-3X} NA P{nos-tub:nos+2'(F)-3X} NA P{nos-tub:nos+2'ME-3X} NA P{nos-tub:nos+2(^)} NA P{nos-tub:nos+2(A)} NA P{nos-tub:nos+2(A)G:C} NA P{nos-tub:nos+2(C)} NA P{nos-tub:nos+2(D)G:C} NA P{nos-tub:nos+2(E)} NA P{nos-tub:nos+2(RO)} NA P{nos-tub:nosIIA/U+U51A} NA P{nos-tub:TCE.IIIA/U.Tloop} NA P{nos-tub:TCE.IIIA/U^C72} NA P{nos-tub:TCE.IIIA/U} NA P{nos-tub:TCE.IIIA.Tloop} NA P{nos-tub:TCE.IIIA} NA P{nos-tub:TCE.IIIGC/GC} NA P{nos-tub:TCE.IIIGC} NA P{nos-tub:TCE.IIIU} NA P{nos-tub:TCE.SRE-} NA P{nos-tub:TCE.ΔProxIII} NA P{nos-tub:TCEII^III} NA P{nos-tub:TCEIIA/U} NA P{nos-tub:TCEIIA} NA P{nos-tub:TCEIII.TLoop} NA P{nos-tub:TCEIII.U51A} NA P{nos-tub:TCEIIU} NA P{nos-tub:TCEIIUC:AG} NA P{nos-tub:virTCE} NA P{nosΔ10} NA P{nosΔLS-(ms2).18} NA P{TCE1} NA P{TCE2} NA P{TCE3} NA P{TCE4} NA P{TCE5} NA P{TCE6} NA P{TCE7} NA P{TCE8} NA P{TCE9} NA
Insertions
	Type of insertions Name Expression data insertion of enhancer trap P{lacW}nosj3B6 No P{lacW}nosj4B6 No P{PZ}nos01536 No P{PZ}nos05678 No P{PZ}nos07117 No insertion of mobile activating element P{EPgy2}CG11779EY01331 NA P{EPgy2}nosEY00281 NA P{GSV1}GSd302GSd302 NA P{GSV2}CG11779GS5240 NA P{Mae-UAS.6.11}nosUY4741 NA insertion of enhancer trap binary system P{GawB}nosNP4407 No P{GawB}nosNP4727 No P{GawB}nosNP5363 No miscellaneous insertions P{5'SUPor-P}nosScim NA P{}nosBN NA P{RS3}nosCB-6897-3 NA P{UAST-YFP.Rab40.H25N}CG1177901 NA PBac{PB}nosc01494 NA
Gene Ontology: Function, Process & Cellular Component ( 21 unique terms )
Terms Based on Experimental Evidence ( 8 terms )
Molecular Function
CV term Evidence References
protein binding inferred from physical interaction with brat (assigned by UniProtKB) (Sonoda and Wharton, 2001) inferred from physical interaction with cup (Verrotti and Wharton, 2000)
Biological Process
CV term Evidence References
dendrite morphogenesis inferred from mutant phenotype (Ye et al., 2004, Brechbiel and Gavis, 2008) female meiosis chromosome segregation inferred from mutant phenotype (Dobie et al., 2001) germ cell development inferred from mutant phenotype (Wang and Lin, 2004) germ-line stem cell maintenance inferred from direct assay (Li et al., 2009) negative regulation of apoptosis inferred from genetic interaction with W (Sato et al., 2007) oogenesis inferred from mutant phenotype (Bhat, 1999) spermatogenesis inferred from mutant phenotype (Bhat, 1999)
Cellular Component ( 0 terms)
Terms Based on Predictions or Assertions ( 14 terms )
Molecular Function
CV term Evidence References
RNA binding inferred from electronic annotation with InterPro:IPR008705 (FlyBase Curators et al., 2004-) zinc ion binding inferred from electronic annotation with InterPro:IPR001878, InterPro:IPR008705 (FlyBase Curators et al., 2004-)
Biological Process
CV term Evidence References
anterior/posterior axis specification, embryo non-traceable author statement (Swiss-Prot Project Members, 1992.5.1) traceable author statement (Baek and Lee, 1999) cell fate determination traceable author statement (Deng and Lin, 2001) germ cell development traceable author statement (Deng and Lin, 2001) germ cell migration traceable author statement (Wylie, 1999, Coffman, 2003) germ-line cyst formation non-traceable author statement (Deng and Lin, 2001) germ-line stem cell division non-traceable author statement (Mahowald, 2001) mRNA polyadenylation traceable author statement (Johnstone and Lasko, 2001) negative regulation of transcription, DNA-dependent traceable author statement (Leatherman and Jongens, 2003) negative regulation of translation non-traceable author statement (Dean et al., 2002) traceable author statement (Deng and Lin, 2001, Johnstone and Lasko, 2001, Lall and Patel, 2001, Leatherman and Jongens, 2003) oocyte anterior/posterior axis specification non-traceable author statement (Martin-Blanco, 2000) pole cell migration traceable author statement (Leatherman and Jongens, 2003)
Cellular Component
CV term Evidence References
pole plasm traceable author statement (van Eeden and St. Johnston, 1999)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions nos allele Gene References nos18 cup (Verrotti and Wharton, 2000) dpp (Gilboa and Lehmann, 2004) tkv (Gilboa and Lehmann, 2004) nosbcd.3UTR bcd (Simpson-Brose et al., 1994) hb (Schulz and Tautz, 1994) nosBN Sxl (Deshpande et al., 1999) nosGMR.PW pum (Wharton et al., 1998) nosL7 hb (Arrizabalaga and Lehmann, 1999, Bajusz et al., 2001) nosM82 osk (Wilson et al., 1996) nosN5 capu (Wang and Lehmann, 1991) osk (Wang and Lehmann, 1991) pum (Wang and Lehmann, 1991) spir (Wang and Lehmann, 1991) stau (Wang and Lehmann, 1991) tud (Wang and Lehmann, 1991) vas (Wang and Lehmann, 1991) vls (Wang and Lehmann, 1991) nosnos.+2'ME-3X.T:Ivir\HA1 vas (Bergsten et al., 2001) nosP51 osk (Wilson et al., 1996) nosSRE1.SRE2 osk (Smibert et al., 1996) nosunspecified E(z) (Pelegri and Lehmann, 1994) pho (Pelegri and Lehmann, 1994) nosαTub84B.3'UTR.Scer\UAS pum (Ye et al., 2004) nosαTub84B.UTR.T:Ivir\HA1 vas (Crucs et al., 2000) unspecified stwl (Maines et al., 2007)
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 67295 DroID - A comprehensive database of gene and protein interactions. • FBgn0002962 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 42297
Orthologs
Genome-wide drosophilid orthologs	Dana\nos Dere\GG23152 Dgri\GH19104 Dmoj\GI23557 Dsec\nos Dsim\nos Dvir\nos Dwil\GK14056 Dyak\GE25585
Curated drosophilid orthologs	Dana\nos   Dbip\nos   Dmei\nos   Dmmm\nos   Dmpl\nos   Dnin\nos   Dpbp\nos   Dpse\GA19020   Dpsp\nos   Dsec\nos   Dsim\nos   Dvar\nos   Dvir\nos
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL012107-PA Aedes aegypti (mosquito) 85485 Branchiostoma floridae (lancelet) ENSCINP00000009192 Ciona intestinalis (sea squirt) PP03739 Pristionchus pacificus (nematode) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • NV18258 LH25627 ISCW024692 FBgn0242648 FBgn0232217 FBgn0013918 FBgn0025032 FBgn0025051 JGI_V11_109359 FBgn0146283 FBgn0126571 FBgn0115304 FBgn0083867 CPIJ011551 BGIBMGA005417 BGIBMGA005410 BGIBMGA002187 ACYPI27888 ACYPI24752 ACYPI20951 AGAP006098 AAEL012107 PB22443 GLEAN_01298_B
Stocks & Reagents
Stocks Listed in FlyBase ( 21 )
Bloomington	3254 st1 pum13 nosL7 e1 32985 y1 sc* v1; P{TRiP.HMS00785}attP2 33973 y1 sc* v1; P{TRiP.HMS00930}attP2 7347 y1 w67c23; P{Mae-UAS.6.11}nosUY4741 28300 y1 v1; P{TRiP.JF02931}attP2/TM3, Sb1 3285 st1 nosL7 e1/TM3, Sb1 Ser1
Harvard	- PBac{PB}nosc01494
Kyoto	106942 st1 pum13 nosL7 e1 106957 st1 nosL7 e1/TM3, Sb1 124257 w1118; P{RS3}nosCB-6897-3 / TM6C, Sb1 113697 w*; P{GawB}nosNP5363 / TM6, P{UAS-lacZ.UW23-1}UW23-1
VDRC	v22693 w1118; P{GD11715}v22693
	More stocks available...
Genomic Clones ( 2 )
	BACR17F04 BACR48G05 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 56 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	LD32741 RE53469
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones
Other clones	39377 65622 70227 214435.71 Dmel_dig_011303_0678_2079 Dmel_dig_011971_0664_2111 Dmel_neb_015231_0399_2294 EK156317 EK193028 EK197934 EP08756 FGC027G04 RP003018390 RP003045649 RP003047291 RP003108210 RP003110519 RP003112429 RP003120986 RP003126406 RP003175883 RP003176807 RP003225829 RP003238781 RP003240045 RP003247803 RP003260233 RP003262981 RP003274554 RP003276077 RP003285219 RP003311489 RP003315519 RP003319548 RP003337697 RP003354886 RP003355321 RP003389815 RP003430434 RP003442815 RP003507813 RP003512287 RP003521148 RP003527284 RP003536812 RP003539442 RP003547708 RP003558758 RP003577575 RP003616851 RP003625529 RP003654237 RP003657783 RP003670892
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0002962 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 42297
Antibody Information
	polyclonal (Gilboa and Lehmann, 2004, Wang et al., 1994)
Other Information
Discoverer
	Lehmann.
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of	Source for merge of: nos l(3)j3B6 (Spradling et al., 1999)
Additional comments
Other Comments
	Regulation of nos protein expression in wild-type germaria depends on sequences in the 3'UTR of the transcript. (Li et al., 2009) nos is not required for the initial elaboration of dendritic branches in class IV da neurons, but is required at later stages of development to maintain dendrite complexity. (Brechbiel and Gavis, 2008) nos mRNA localisation is dispensible for normal abdominal patterning in the embryo, providing that nos translation is properly modulated. In contrast, localisation of nos mRNA to the germ plasm, but not translational regulation, is essential for nos function in the developing germ cells. (Gavis et al., 2008) nos is essential for establishing and maintaining germline stem cells by preventing their precocious entry into oogenesis. nos is required cell autonomously for germline stem cell renewal (though not cyst differentiation). It is likely that nos represses the translation of differentiation factors in primoridal germ cells and germline stem cells. Zygotic nos is required at two distinct phases during pre-oogenic PGC development. The first pase is embryonic to first larval instar. The second phase is from the late third-instar to the pupal stage, that spans germline stenm cell establishment. (Wang and Lin, 2004) nos and pum control the elaboration of high-order dendritic branches of class III and IV, but not class I and II, dendritic arborization neurons. nos and pum require each other to control dendrite morphogenesis, but hb is not required. (Ye et al., 2004) Posterior localization of nos RNA initiates immediately upon nurse cell dumping and occurs by diffusion, entrapment and actin-dependent anchoring of RNA entering the oocyte. Long range movement of nos RNA can occur in the absence of oocyte streaming. (Forrest and Gavis, 2003) The CCHC zinc finger motifs of nos, which coordinate two metal ions, are essential for all known functions of the nos protein. The "tail region" C-terminal to the zinc fingers is required for abdomen formation and germ cell migration, but not for oogenesis. (Arrizabalaga and Lehmann, 1999) The joint action of two RNA degradation pathways (a maternally encoded and a zygotic pathway) controls maternal transcript degradation and its timing in the early embryo. nos transcripts (relatively rare in abundance) are degraded almost exclusively by the maternal pathway. (Bashirullah et al., 1999) Localisation of nos RNA by components of the posteriorly localised germ plasm activates its translation by preventing interaction of nos RNA with translational repressors. (Bergsten and Gavis, 1999) In the female germ line nos is required for the functioning of stem cells. In the male germline, nos is required for the maintenance of stem cells. (Bhat, 1999) In mutant females, germline stem cells divide only a few times and then degenerate, due to loss of plasma membrane. Following germ cell loss, germaria carry on massive mitochondrial biogenesis activity. In mutant males, spermatogenesis is progressively affected and the males eventually become sterile. (Bhat, 1999) The developmental defects of nos- pole cells can be traced to the blastoderm stage. nos- pole cells, but not nos+ pole cells, are transcriptionally active in the blastoderm. The nos- pole cells also abnormally continue dividing, instead of becoming quiescent. Sxl is an important target for repression by nos in germ cells. (Deshpande et al., 1999) The nos gene product forms a ternary complex with the RNA-binding domain of pum and the hb NRE (nos response element). (Sonoda and Wharton, 1999) Maternally deposited nos is essential for normal germ cell migration. Lack of zygotic activity of nos and pum has a dramatic effect on germline development of homozygous females. nos and pum act in the germline, affecting germline stem cell development. nos function lies in the differentiation of the stem cell progeny, the cystoblast. nos and pum may interact with different partners in the germline. (Forbes and Lehmann, 1998) Germ cells of embryos deriving from nos females do not show premature enhancer trap line gene expression, contrary to previous reports (FBrf0087514). (Heller and Steinmann-Zwicky, 1998) In a sample of 79 genes with multiple introns, 33 showed significant heterogeneity in G+C content among introns of the same gene and significant positive correspondence between the intron and the third codon position G+C content within genes. These results are consistent with selection adding against preferred codons at the start of genes. (Kliman and Eyre-Walker, 1998) A Cys-Cys-His-Cys metal-binding domain in nos is essential for translational regulation. Each of two CCHC motifs are essential for nos activity. Each is capable of binding Zn(II) or Co(II) ions. nos binds to RNA with high affinity but cannot alone discriminate between mutant and wild-type NRE RNAs. (Curtis et al., 1997) A study of the mechanisms of nos-mediated translational repression indicates that nos and pum determine posterior morphology by promoting the deadenylation of maternal hb mRNA, thereby repressing its translation. (Wreden et al., 1997) The nos protein gradient in embryos is generated by translational regulation acting through the 184bp TCE (Translational Control Element) of the 3' UTR. The TCE is required to prevent the translation of unlocalized nos mRNA. (Dahanukar and Wharton, 1996) Cis-acting sequences within the nos 3'UTR, both necessary and sufficient for localisation of RNA to the posterior of the embryo, occupy a 547 nucleotide region and contain sequences that are partially redundant in function. (Gavis et al., 1996) A 90 nucleotide region of the nos 3'UTR is identified that mediated translational repression of unlocalised nos RNA, this region is designated as the nos translational control element (TCE). (Gavis et al., 1996) nos is essential for germline formation, pole cells lacking nos activity fail to migrate into the gonads so do not become functional germ cells. In such pole cells, gene expression begins prematurely during pole cell migration. Premature activation of genes in these germline precursors may mean that these cells fail to develop normally. (Kobayashi et al., 1996) smg protein represses translation of unlocalized nos mRNA in the embryo. Two SREs (smg Response elements) map to the nos 3' UTR. (Smibert et al., 1996) nos is a conserved organiser of anterior-posterior patterning in the Diptera. (Curtis et al., 1995) Posterior localisation of the nos RNA is mediated by sequences within the 3' untranslated region and requires the function of eight posterior group genes. Unlocalised nos RNA is translationally repressed, this repression is mediated by the 3' untranslated region. Sequences that mediate translational repression overlap but are independent of those required for localisation. (Gavis and Lehmann, 1995) Variation of a microsatellite within the nos locus has been studied in North American populations of D.melanogaster. (Goldstein and Clark, 1995) nos response elements (NRE) in the hb mRNA mediate nos repression of hb maternal transcript translation. pum protein is an NRE binding factor, pum recognises the NRE and recruits nos, the resulting complex is thought to inhibit some component of the translation machinery. (Murata and Wharton, 1995) A small part of the nos 3'UTR, called NTE1, inhibits translation of the nos product. Additional sequences in the 3'UTR are required for posterior group gene-dependent activation of nos translation. (Smibert et al., 1995) The nos gene product primarily recognises nanos response element (NRE) bound proteins, the pum gene product, and this complex interferes with translation of hb mRNA. (Wharton et al., 1995) Posterior localisation of nos RNA is mediated by sequences within the nos 3' untranslated region (3'UTR) and required the function of eight genes of the posterior group. Unlocalised nos RNA in embryos mutant for any of the posterior genes is stable and the embryos develop abdominal defects characteristic of nos mutants. Unlocalised nos RNA is translationally repressed, repression is mediated by the 3' UTR and can be alleviated by replacement of the UTR with heterologous UTR sequences or posterior localisation. (Gavis and Lehmann, 1994) nos is involved in the directed intercalation of cells during germ band extension. (Irvine and Wieschaus, 1994) Comparisons of early development to that in other insects have revealed conservation of some aspects of development, as well as differences that may explain variations in early patterning events. (Patel, 1994) A screen for suppressors of nos mutations identified alleles of E(z). E(z) is required to maintain the expression domain of kni and gt initiated by the maternal hb gradient. A small region of the kni promoter mediates regulation by E(z) and hb. Imprinting at the chromatin level may underlie the determination of anteroposterior polarity in the early embryo. (Pelegri and Lehmann, 1994) Distribution of tud protein in mutant embryos has been studied. (Bardsley et al., 1993) pumilio, expressed in the same pattern as nanos, is not required for either the expression of nanos protein or its transport to the presumptive abdomen. (Barker et al., 1992) nanos 3' untranslated region is sufficient for nanos RNA localization. In experiments using bicoid sequences to mislocalise nanos, embryos with mirror image symmetry with double abdomens result if nanos is localised at both the anterior and posterior ends. Anteriorly localised nos suppresses translation of maternally supplied hunchback mRNA and thereby alters gap gene expression. (Gavis and Lehmann, 1992) Overexpression of osk leads to higher levels of osk mRNA that is both correctly localised to the posterior pole and unlocalised. Consequently nos is activated ectopically causing extensive shifts in body patterning. Germ cell formation is also affected, this can be enhanced by genetically decreasing nos activity. (Smith et al., 1992) nos acts to prevent the expression of hb in the posterior half of the embryo. (Eldon and Pirrotta, 1991) Expression from the Ecol\lacZ-Kr730 Kr-promoter fusion construct was monitored in nos- embryos to ensure the target site for nos mediated Kr expression has not been lost. (Hoch et al., 1991) gt may respond to the posterior morphogen nos in the embryo. nos represses maternal hb expression post-transcriptionally, so the effect of nos on gt expression may be mediated through hb. (Kraut and Levine, 1991) nos is critical for pole plasm formation and is required for the synthesis of the posterior signal in the nurse cells. The distribution of the signal to the presumptive posterior pole occurs after egg deposition. BicD,nos embryos suppress all abdominal development: the nos gene is critical for the normal and ectopic presence of the posterior signal. (Lehmann and Nusslein-Volhard, 1991) Mutations in maternal posterior class gene nos do not interact with RpII140wimp. (Parkhurst and Ish-Horowicz, 1991) nos gene product has been isolated and characterised. (Wang and Lehmann, 1991) The degree of regulation mediated by the NREs in maternal hb mRNA depends on the level of nos. (Wharton and Struhl, 1991) nos mutants exhibit deletion of the abdomen and pole plasm. (Gaul and Jaeckle, 1990) Mature follicles are immunologically stained for asymmetric distribution of ecdysteroid-related antigen. During late oogenesis localisation of the antigen changes dramatically suggesting the antigen plays a role in early embryogenesis and, perhaps, in pattern formation. (Grau and Gutzeit, 1990) nos gene function is not required for pole cell formation. (Lasko and Ashburner, 1990) nos plays a role in polar granule formation. (Raff et al., 1990) Double anterior structure induction in nos is more efficient by genetic methods, within nos mutant embryos, than removal of posterior cytoplasm. (Sugiyama and Okada, 1990)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_057310 RefSeq (Proteins) • NP_476658 DDBJ / EMBL / GenBank • AA978726 AAA28715 AAF55641 AAL68233 AC006091 AF067873 AQ034086 AW943146 AY075406 CL705877 CZ467207 CZ467208 G00548 M72421 Entrez Gene - A searchable database of RefSeq genes. • 42297 UniProtKB/Swiss-Prot • P25724 UniProtKB/TrEMBL • Q8SY38
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Nanos/Xcat2 (IPR008705) Zinc finger, CCHC-type (IPR001878) Zinc finger, nanos-type (IPR024161) Rfam - RNA families database of alignments and covariance models • RF00161
Linkouts
	BioGRID - A database of protein and genetic interactions • 67295 DroID - A comprehensive database of gene and protein interactions. • FBgn0002962 DRSC - Results from RNAi screens. • FBgn0002962 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0002962 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG5637-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0002962 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 42297 InParanoid A subset of ortholog calls from InParanoid. • AAEL012107-PA Aedes aegypti (mosquito) 85485 Branchiostoma floridae (lancelet) ENSCINP00000009192 Ciona intestinalis (sea squirt) PP03739 Pristionchus pacificus (nematode) Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution • /torstoll/nanos1.htm InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 42297 modMine - Data generated by the modENCODE project. • FBgn0002962 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • NV18258 LH25627 ISCW024692 FBgn0242648 FBgn0232217 FBgn0013918 FBgn0025032 FBgn0025051 JGI_V11_109359 FBgn0146283 FBgn0126571 FBgn0115304 FBgn0083867 CPIJ011551 BGIBMGA005417 BGIBMGA005410 BGIBMGA002187 ACYPI27888 ACYPI24752 ACYPI20951 AGAP006098 AAEL012107 PB22443 GLEAN_01298_B
Synonyms & Secondary IDs ( 13 )
Reported As
Symbol Synonym	CG5637 (Laviolette et al., 2005, Keleman et al., 2009.8.5, Perkins et al., 2009, Ni et al., 2010.12.1) DRONANOS (Fernando Vazquez et al., 2000, Colson and Goldstein, 1999, Schug et al., 1998, Schug et al., 1997, Kennington et al., 2006) Dronanos (Lopez et al., 2002) l(3)07117   l(3)j3B6 (Meister and Braun, 1995.10, BDGP Project Members, 1994-1999, ) l(3)j4B6   NANOS (Colson and Goldstein, 1999) nanos (Muraro et al., 2008) nNOS (Yamaguchi et al., 2006) nos (Jain and Gavis, 2007, Wawersik and Van, 2005, Anne et al., 2007, Deshpande et al., 2006, Deshpande et al., 2007, Gamberi and Lasko, 2007, Goldman et al., 2007, Kalifa and Gavis, 2007, McGregor, 2006, Laviolette et al., 2005, Shigenobu et al., 2006, Shapiro and Anderson, 2006, Arkov et al., 2006, Jeske et al., 2006, Zaessinger et al., 2006, Gavis et al., 2008, Maines et al., 2007, Zhang et al., 2007, Snowflack and Gavis, 2008, Lerit et al., 2008, Gamberi and Lasko, 2008, Lecuyer et al., 2007, Kadyrova et al., 2007, Weil et al., 2006, Sano et al., 2005, Jain and Gavis, 2008, Georlette et al., 2007, Song et al., 2007, Minidorff et al., 2007, Minidorff et al., 2007, Sato et al., 2007, Blankenship et al., 2006, Tadros et al., 2007, Cinnamon et al., 2008, Benoit et al., 2008, Pope and Harris, 2008, Spirov et al., 2009, Brechbiel and Gavis, 2008, Weil et al., 2008, Verrotti et al., 1999, Rangan et al., 2009, Rhiner et al., 2009, Wang et al., 1994, Xie et al., 2005, Brechbiel and Gavis, 2008, Maezawa et al., 2009, Li et al., 2009, Chen et al., 2009, Fernandez-Gonzalez et al., 2009, Lim et al., 2009, Sheng et al., 2009, Kim et al., 2010, Becalska and Gavis, 2010, Flaherty et al., 2010, Jin et al., 2008, Leatherman and DiNardo, 2008, Kitadate and Kobayashi, 2010, Becalska et al., 2011, Jeske et al., 2011, Yatsu et al., 2008, Janic et al., 2010, Lerit and Gavis, 2011, Smibert et al., 1999, Garcia et al., 2011, Sinsimer et al., 2011, Parisi et al., 2004, Rouget et al., 2010, Tchuraev and Galimzyanov, 2009, Andrews et al., 2011) NOS (Peel et al., 2005, Megosh et al., 2006, Megosh et al., 2006, Thomson and Lasko, 2004) Nos (Trainor, 2004, Cho et al., 2006, Yu et al., 2008, Maines et al., 2008, Kim et al., 2010, Harris et al., 2011, Zhang et al., 2011)
Name Synonym	nanos (Colson, 1998.5.26, Jain and Gavis, 2007, Wawersik and Van, 2005, Anne et al., 2007, Deshpande et al., 2007, Andrews and Gavis, 2007, Kalifa and Gavis, 2007, Ho and Gavis, 2007, Nystul and Spradling, 2006, Seydoux and Braun, 2006, Shigenobu et al., 2006, Shapiro and Anderson, 2006, Jeske et al., 2006, Zaessinger et al., 2006, Kalifa et al., 2006, Pavesi et al., 2004, Gavis et al., 2008, Lemke et al., 2008, Lerit et al., 2008, Shav-Tal and Singer, 2005, Jain and Gavis, 2008, Blankenship et al., 2006, da Silva and Vincent, 2007, De Renzis et al., 2007, Cinnamon et al., 2008, Pope and Harris, 2008, Spirov et al., 2009, Brechbiel and Gavis, 2008, Weil et al., 2008, Parrish et al., 2007, McGraw et al., 2008, Rangan et al., 2009, Rhiner et al., 2009, Lu et al., 2009, Lim et al., 2009, Li et al., 2009, Sheng et al., 2009, Sato et al., 2008, Gurunathan et al., 2004, Martin et al., 2010, Holloway and Harrison, 1999, Jeske et al., 2011, Yatsu et al., 2008, Janic et al., 2010, Eliazer et al., 2011, Yu et al., 2010, Smibert et al., 1999, Johnson and Donaldson, 2006, Sinsimer et al., 2011) Nanos (Pinder et al., 2007, Maines et al., 2007, Cho et al., 2006, Strome and Lehmann, 2007, Niki et al., 2006, Niki, 2006, Nurminsky, 2007, Maines et al., 2007, Yu et al., 2008, Nomie and Wharton, 2008, Kadyrova et al., 2007, Leatherman and DiNardo, 2008, Kitadate and Kobayashi, 2010, Kim et al., 2010, Tastan et al., 2010, Zhang et al., 2011)
Secondary FlyBase IDs
	FBgn0010916 FBgn0011347 FBgn0011364 FBgn0026836
References ( 576 )
Generate a list of	All references relating to this gene ( 576 )
List References by type	Research paper  ( 267 ) Supplementary material  ( 9 ) Review  ( 149 ) Erratum  ( 1 ) Personal communication to FlyBase  ( 10 ) Abstract  ( 119 ) FlyBase analysis  ( 3 ) DNA/RNA sequence record  ( 1 ) Computer file  ( 4 ) Conference report  ( 6 ) Stock list  ( 1 ) Protein sequence record  ( 1 ) Automatic genome annotation  ( 1 ) Letter  ( 2 ) Curated genome annotation  ( 1 ) Book  ( 1 )
Recent research papers ( 19 )
	Andrews et al., 2011, RNA 17(5): 967--977 Multiple mechanisms collaborate to repress nanos translation in the Drosophila ovary and embryo. [FBrf0213495] Becalska et al., 2011, Dev. Biol. 349(1): 46--52 Aubergine is a component of a nanos mRNA localization complex. [FBrf0212348] Eliazer et al., 2011, Proc. Natl. Acad. Sci. U.S.A. 108(17): 7064--7069 Loss of lysine-specific demethylase 1 nonautonomously causes stem cell tumors in the Drosophila ovary. [FBrf0213593] Garcia et al., 2011, BMC Mol. Biol. 12: 32 Functional characterization of the sciarid BhC4-1 core promoter in transgenic Drosophila. [FBrf0214770] Harris et al., 2011, Dev. Cell 20(1): 72--83 Brat Promotes Stem Cell Differentiation via Control of a Bistable Switch that Restricts BMP Signaling. [FBrf0212787] Jeske et al., 2011, EMBO J. 30(1): 90--103 Smaug assembles an ATP-dependent stable complex repressing nanos mRNA translation at multiple levels. [FBrf0212721] Lerit and Gavis, 2011, Curr. Biol. 21(6): 439--448 Transport of germ plasm on astral microtubules directs germ cell development in Drosophila. [FBrf0213255] Sinsimer et al., 2011, Development 138(16): 3431--3440 A late phase of germ plasm accumulation during Drosophila oogenesis requires Lost and Rumpelstiltskin. [FBrf0214542] Zhang et al., 2011, Dev. Biol. 353(2): 259--265 Drosophila long-chain acyl-CoA synthetase acts like a gap gene in embryonic segmentation. [FBrf0213522] Becalska and Gavis, 2010, Dev. Biol. 340(2): 528--538 Bazooka regulates microtubule organization and spatial restriction of germ plasm assembly in the Drosophila oocyte. [FBrf0210533] Flaherty et al., 2010, Dev. Cell 18(4): 556--568 chinmo is a functional effector of the JAK/STAT pathway that regulates eye development, tumor formation, and stem cell self-renewal in Drosophila. [FBrf0210682] Janic et al., 2010, Science 330(6012): 1824--1827 Ectopic expression of germline genes drives malignant brain tumor growth in Drosophila. [FBrf0212713] Kim et al., 2010, Curr. Biol. 20(5): 446--451 MAPK Substrate Competition Integrates Patterning Signals in the Drosophila Embryo. [FBrf0210220] Kim et al., 2010, J. Biol. Chem. 285(7): 4741--4746 Direct inhibition of pumilo activity by bam and bgcn in Drosophila germ line stem cell differentiation. [FBrf0209919] Kitadate and Kobayashi, 2010, Proc. Natl. Acad. Sci. U.S.A. 107(32): 14241--14246 Notch and Egfr signaling act antagonistically to regulate germ-line stem cell niche formation in Drosophila male embryonic gonads. [FBrf0211513] Martin et al., 2010, J. Cell Biol. 188(5): 735--749 Integration of contractile forces during tissue invagination. [FBrf0210158] Rouget et al., 2010, Nature 467(7319): 1128--1132 Maternal mRNA deadenylation and decay by the piRNA pathway in the early Drosophila embryo. [FBrf0212183] Tastan et al., 2010, Development 137(19): 3167--3176 Drosophila Ataxin 2-binding protein 1 marks an intermediate step in the molecular differentiation of female germline cysts. [FBrf0211752] Yu et al., 2010, genesis 48(3): 161--170 E(nos)/CG4699 required for nanos function in the female germ line of Drosophila. [FBrf0210233] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2010 Show reviews ...