Gene Dmel\nw

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General Information

Symbol

Dmel\nw

Species

D. melanogaster

Name

narrow

Annotation symbol

Feature type

gene

FlyBase ID

FBgn0002974

Created / Updated

2006-08-22/2006-08-22

Genomic Location

Chromosome (arm)

Recombination map

Cytogenetic map

54A1-55A4

Sequence location

Summary Information

Automatically generated summary

See sections below for more information

The gene narrow is referred to in FlyBase by the symbol nw (FBgn0002974). It has the cytological map location 54A1-55A4. It has not been localized to the genome sequence. Its molecular function is unknown. The biological processes in which it is involved are not known. 4 alleles are reported. The phenotypes of these alleles are annotated with: wing; wing margin bristle; ovary; oogonial cell; egg chamber. It has no annotated transcripts.

Phenotypic Description from the Red Book (Lindsley & Zimm 1992)

Gene/Allele symbols may differ from current usage

*nw: narrow

Wings long, narrow, and somewhat pointed. Low viability and fertility in both sexes. At 25C, may overlap wild type; at 19, nearly all flies approach wild type but have longer wings. RK2.

nw2

nw2: narrow 2
From Payne, 1924, Genetics 9: 327-42.

Wings like nw, long, narrow, and somewhat pointed. Classification easier in females. Slight notching or tufting of marginal hairs on tip of wings. Both sexes nearly sterile. Ovaries tumorous at eclosion [King, Burnett, and Staley, 1957, Growth 21: 239-61 (fig.); King, 1964, Roy. Entomol. Soc. (London) Symp. Insect Reproduction, pp. 13-25]. Oogonia proliferate asynchronously within ovariole; follicle development inhibited [Beatty, 1949, Proc. R. Soc. Edinburgh, B 63: 249-70 (fig.)]. RK2.

nwB: narrow-Blade

Wings of nwB/+ long and narrow; variable but does not overlap wild type. Female fertility reduced. Homozygote and nwB/nw2 heterozygote lethal. RK2.

nwD: narrow-Dominant

Wings of heterozygote longer and narrower than normal. Expression variable and sometimes approaches wild type. Viability of nwD/+ low. Homozygous lethal, as is nwD/nw2. RK2.

Detailed Mapping Data

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

54A1-55A4

Left limit from recombination mapping relative to mapP (FBrf0045961) Right limit from recombination mapping relative to Bc (FBrf0063385)

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

Experimentally Determined Recombination Data

Location

2-79.6

(Rizki et al., 1980)

2-79.3 +/- 0.2

(Doane and Clark, 1984)

2-75

(Craymer, 1980)

Left of (cM)

(Doane and Clark, 1984)

(Craymer, 1980)

Right of (cM)

(Craymer, 1980)

(Doane and Clark, 1984)

mapP

(Doane, 1987)

Notes

Based on mapping of nw^D.

(Rizki et al., 1980)

Based on mapping of nw².

(Doane and Clark, 1984)

Molecular Map Data

Gene Order (in direction of increasing cytology)

References

Gene Order (overall orientation not stated)

References

Gene Model & Products

Comments on Gene Model

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Associated CDS (aa)

Additional Transcript Data & Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kD)

Length (aa)

Theoretical pI

RefSeq ID

GenBank protein

Additional Polypeptide Data & Comments

Reported size (kD)

Comments

External Data

Linkouts

Crossreferences

Sequences Consistent with the Gene Model

DDBJ /
EMBL /
GenBank

DNA sequence

Protein sequence

Name

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Maps to

Does NOT map to

Identified with

Mapped Features & Mutations

Type

Symbol & Location

Additional Notes

References

External Data

Linkouts

Crossreferences

Expression Data

FlyBase-Curated Data

Transcript and
Protein data

Please see the FlyBase Gene Expression Report for details of gene expression from the literature.

Summary of Transcript Expression

Stage

Tissue/Position

Reference

Marker for

Subcellular Localization

CV Term

Summary of Polypeptide Expression

Stage

Tissue/Position

Reference

Marker for

Subcellular Localization

CV Term

External Data & Images

Linkouts

FLIGHT - Cell culture data for RNAi and other high-throughput technologies

•

FBgn0002974

Alleles & Phenotypes

Summary of Allele Phenotypes

Lethality

Allele

viable | poor

nw¹

lethal | recessive

nw^B

Other Phenotypes

Allele

visible

visible | dominant

Sterility

Allele

female sterile

nw²

male sterile

nw²

fertile | poor

nw¹

female fertile | dominant | reduced

nw^B

Phenotype manifest in

Allele

wing

wing margin bristle

nw²

ovary

nw²

oogonial cell

nw²

egg chamber

nw²

Classical Alleles ( 4 )

For All Classical Alleles Show

Allele of nw	Mutagen	Stocks	Known lesion
nw¹	spontaneous	0	--
nw²	spontaneous	2	--
nw^B	X ray	6	--
nw^D	X ray	7	--

Alleles Carried on Transgenic Constructs ( 0 )

For All Alleles Carried on Transgenic Constructs Show

Allele of nw	Class	Mutagen	Stocks	Known lesion

Aneuploid Aberrations

Useful duplication

Dp(2;Y)53D;57C

Transgenic Constructs & Insertions

Transgenic Constructs

Type of construct

Name

Expression data

Insertions

Type of insertions

Name

Expression data

Related Comments

Please look at the allele reports for the complete phenotype data

Mutants display germline hyperplastic phenotype.

(Mechler, 1994)

Gene Ontology: Function, Process & Cellular Component ( 0 )

Molecular Function

CV term

Evidence

References

Biological Process

CV term

Evidence

References

Cellular Component

CV term

Evidence

References

Sequence Ontology: Class of Gene

gene

Interactions & Pathways

Summary of Genetic Interactions

Interacts with

Please look at the allele data for full details of the genetic interactions

nw allele

Gene

References

unspecified

(Bien-Willner and Doane, 1997, Bien-Willner et al., 1997)

External Data

Linkouts

BioGRID - Interaction data, including yeast 2-hybrid and genetic interactions

•

68732

Orthologs

Genome-wide drosophilid orthologs

Curated drosophilid orthologs

Linkouts

Functional Complementation between Species

Inter-Species Misexpression Data

Produces phenotype in

Produces NO phenotype in

Stocks & Reagents

Stocks Listed in FlyBase ( 15 )

Bloomington

240

nw^B/SM5

359

nw²/In(2L)Cy, In(2R)NS, Cy¹

2605

Df(2R)Pu-D17, nw^D Pin^Yt/SM1

1571

nw^D Pin^Yt/CyO; ry⁵⁰⁶ e¹

1564

nw^D Pu² Egfr^E1 Pin^Yt/SM1

3981

L¹ Got1^lo nw^D/CyO, P{sevRas1.V12}FK1

Kyoto

105809

nw^B/SM5

107425

Df(2R)Pu-D17, nw^D Pin^Yt/SM1

101514

In(2L)Cy In(2R)NS, Cy¹ / nw²

106392

nw^D Pin^Yt/CyO; ry⁵⁰⁶ e¹

106389

nw^D Pu² Egfr^E1 Pin^Yt/SM1

107694

S¹ wg^Sp-1 Tft¹ nw^B Pin^Yt/CyO

More stocks available...

Genomic Clones ( 0 )

cDNA Clones ( 0 )

cDNA Clones, Fully Sequenced

BDGP DGC clones

Other clones

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi & Array Information

Affy Oligo

Linkouts

Antibody Information

Other Information

Discoverer

Etymology

Identification

Position Effect Variegation Data

Relationship to Other Genes

Source for database identity of

Source for database merge of

Additional comments

Comments About Role

Comments About Molecular Function

Other Comments

Genetic combinations with mutants of nub cause additive phenotypes.

(Cifuentes and Garcia-Bellido, 1997)

External Crossreferences & Linkouts

Sequence Crossreferences

Other Crossreferences

Linkouts

BioGRID - Interaction data, including yeast 2-hybrid and genetic interactions

•

68732

FLIGHT - Cell culture data for RNAi and other high-throughput technologies

•

FBgn0002974

Synonyms & Secondary IDs ( 5 )

Reported As

Symbol Synonym

Bla

lance

Name Synonym

Blade

narrow

Secondary FlyBase IDs

References ( 29 )

Generate a list of

All references relating to this gene ( 29 )

List References by type

Research paper ( 18 )
Review ( 5 )
Abstract ( 4 )
Book ( 2 )

Recent research papers (0)

All research papers listed in FlyBase were published before 2006

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Recent reviews (0)

All reviews listed in FlyBase were published before 2006

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