• Home
• Tools
  • Tools Overview
  • Query Tools

    
    • QuickSearch
    • QueryBuilder
    • TermLink
    • CytoSearch
    • RNA-Seq Search
    • Interactions Browser
    • ImageBrowse
    • Find A Person
    • Google™ FlyBase
  • Genomic/Map Tools

    
    • BLAST
    • GBrowse
    • GBrowse 2 Beta
    • CytoSearch
    • Feature Mapper
    • Aberrations Maps
    • Chromosome Maps
    • Coordinates Converter
  • Retrieve/Convert

    
    • Batch Download
    • Coordinates Converter
    • ID Converter
  • Data Submission

    
    • Fast-Track Your Paper
    • Submit Personal Comm
    • Add A New Person
    • Update Person Info
  • People

    
    • Find A Person
    • Add A New Person
    • Update Person Info
• Files
  • Files Overview
  • Current release
  • Archived releases
  • Map Conversion
  • FTP site:
  • Releases (FTP)
  • Genomes (FTP)
• Species
  • Phylogeny
  • Sequenced Species
  • Synteny Table
  • Color Illustrations
  • Abbreviations
• Documents
  • About FlyBase
  • Reference Manual:
  • Sections
  • Contents
  • Nomenclature
  • Release Notes
• Resources
  • All Resources
  • Model Organisms
  • Stock Collections
  • Vectors & Constructs
  • Other links:
  • BDGP
  • DGRC
  • DIS by issue
  • FlyExpress
  • Interactive Fly
  • modENCODE
  • Textpresso for Fly
• News
  • News
  • FlyBase Forum
  • FlyBase Positions
  • Meetings
  • Courses
  • Fly Board
  • White papers
  • Funding
  • bionet.dros
• Help
  • Google™ FlyBase
  • Site Map
  • FAQs
  • FlyBase Guides
  • Video Tutorials
  • Report help
  • New to Flies
  • Pers. comm.
  • Author guidelines
  • Contact FlyBase
• Archives
  • Prior Release
  • Other Archives
  • Coordinate Converter

Gene Dmel\opa

General Information
Symbol	Dmel\opa	Species	D. melanogaster
Name	odd paired	Annotation symbol	CG1133
Feature type	protein_coding_gene	FlyBase ID	FBgn0003002
Gene Model Status	Current	Stock availability	10 publicly available
Genomic Location
Chromosome (arm)	3R	Recombination map	3-48
Cytogenetic map	82D8-82E1	Sequence location	3R:678,535..695,701 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene odd paired is referred to in FlyBase by the symbol Dmel\opa (CG1133, FBgn0003002). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: sequence-specific DNA binding transcription factor activity. There is experimental evidence that it is involved in the biological process: decapentaplegic signaling pathway; eye-antennal disc morphogenesis; germ cell migration; midgut development. 43 alleles are reported. The phenotypes of these alleles are annotated with: multicellular structure; anatomical structure; organ system; acellular anatomical structure; late extended germ band embryo; imaginal precursor; extended germ band embryo; embryonic gnathal segment; non-connected developing system; larval head segment; heart primordium; external compound sense organ. It has one annotated transcript and one annotated polypeptide. Protein features are: Zinc finger C2H2-type/integrase DNA-binding domain; Zinc finger, C2H2; Zinc finger, C2H2-like. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of extremely low expression. Peak expression observed within 00-06 hour embryonic stages. Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: larval central nervous system. Comments on Affy2 ProbeSet: ProbeSet 1628865_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of opa. Gene sequence location is 3R:678535..695701.
User Contributed Data
	Beta version, feedback welcome
External Summaries
Phenotypic Description from the Red Book (Lindsley & Zimm 1992)
Gene/Allele symbols may differ from current usage	opa: odd paired Deletes alternate metasegments, as defined by a line separating the anterior from the posterior parts of the anterior compartments; portions of denticle bands of T2, A1, A3, A5, and A7 and naked cuticle of T3, A2, A4 and A6 missing. Pattern of Ubx protein distribution in the double-sized units reveals them to be composite, the anterior half being derived from an odd-numbered parasegment and the posterior half from an even-numbered parasegment (read metasegment) (Ingham and Martinez-Arias, Nature 324: 592-97). Without discernable effect on ftz expression (Carrol and Scott, 1980, Cell 45: 113-26). However, exhibits loss of en product with a consequent increase in Ubx expression in even-numbered parasegments (Martinez-Arias and White, 1988, Development 102: 325-38).
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 82D8-82E1   Limits computationally determined from genome sequence between P{PZ}l(3)0273302733 and P{EP}EP974
Experimentally Determined Cytological Location
Cytogenetic map Notes References 82A-82E     (Tearle and Nusslein-Volhard, 1987)
Experimentally Determined Recombination Data
Location	3-48 (Tearle and Nusslein-Volhard, 1987)
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\opa for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.49
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) opa-RA FBtr0078836  NM_079504   2939   609
Additional Transcript Data & Comments
Reported size (kB)	3.0 (northern blot) (Benedyk et al., 1994)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein opa-PA   FBpp0078477   66.2   609   8.42     NP_524228   AAF52084
Additional Polypeptide Data & Comments
Reported size (kDa)	609 (aa); 66 (kD predicted) (Cimbora and Sakonju, 1995) 609 (aa) (Benedyk et al., 1994)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Zinc finger C2H2-type/integrase DNA-binding domain (IPR013087) Zinc finger, C2H2-like (IPR015880) Zinc finger, C2H2 (IPR007087)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA950584   AE014297 AAF52084   AW943028   AY051783 AAK93207   BI364445   BT029391   CO189097   CO189099   CO291525   CO310309   CO328116   EC063482   EC203309   EC229831   EC229833   EC248451   EC255394   GH739669   GH739778   GH742409   GH742797   GH743111   GH747362   GH765860   GH766254   GH766944   GH767225   GH767822   GH768401   GH769199   GO254419   GO254443   GO254456   S78339 AAB34592   U04435 AAA18958
UniProtKB/Swiss-Prot	P39768
UniProtKB/TrEMBL
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References regulatory region FBsf0000435479 3R:696,534..703,535 evidence=Reporter construct (in vivo) (Lee et al., 2007, Halfon, 2012.6.19) regulatory region FBsf0000436034 3R:684,034..690,534 evidence=Reporter construct (in vivo) (Lee et al., 2007, Halfon, 2012.6.19) regulatory region FBsf0000436087 3R:677,534..684,534 evidence=Reporter construct (in vivo) (Lee et al., 2007, Halfon, 2012.6.19)
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage 1 -- 3   organism   (Fisher et al., 2012) Comment:maternally deposited embryonic stage 4 -- 6   dorsal ectoderm anlage   (Fisher et al., 2012) Comment:anlage in statu nascendi mesoderm anlage   (Fisher et al., 2012) Comment:anlage in statu nascendi organism | gap expression pattern   (Fisher et al., 2012) organism | ubiquitous   (Fisher et al., 2012) ventral ectoderm anlage   (Fisher et al., 2012) Comment:anlage in statu nascendi embryonic stage 5   organism | 10-80% egg length   (Cimbora and Sakonju, 1995) Comment:16-78% egg length embryonic stage 6   mesoderm   (Cimbora and Sakonju, 1995) ectoderm   (Cimbora and Sakonju, 1995) embryonic stage 7   organism | striped   (Cimbora and Sakonju, 1995, Benedyk et al., 1994) embryonic stage 7 -- 8   dorsal ectoderm   (Fisher et al., 2012) trunk mesoderm   (Fisher et al., 2012) ventral ectoderm   (Fisher et al., 2012) organism | gap expression pattern   (Fisher et al., 2012) organism | faint & ubiquitous   (Fisher et al., 2012) embryonic stage 9 -- 10   ventral ectoderm   (Fisher et al., 2012) organism | faint & ubiquitous   (Fisher et al., 2012) embryonic stage 11 -- 12   visceral mesoderm   (Cimbora and Sakonju, 1995) visceral muscle primordium   (Fisher et al., 2012) organism | faint & ubiquitous   (Fisher et al., 2012) embryonic stage 13 -- 16   embryonic/larval midgut   (Fisher et al., 2012) embryonic/larval visceral muscle   (Fisher et al., 2012) organism | faint & ubiquitous   (Fisher et al., 2012) embryonic stage 13 -- 17   visceral mesoderm of parasegment 9 -- parasegment 12   (Cimbora and Sakonju, 1995) parasegment 5 of visceral mesoderm   (Cimbora and Sakonju, 1995) northern blot Stage Tissue/Position (including subcellular localization) Reference embryonic stage -- pupal stage     (Benedyk et al., 1994) embryonic stage 5   organism | 80% egg length   (Benedyk et al., 1994) Comment:early stage 5 embryonic stage 5 -- 6   organism | 20-80% egg length   (Benedyk et al., 1994)
Additional Descriptive Data
	opa transcripts are detected in embryonic, larval, and pupal stages with peak levels between 2 and 12 hours of embryogenesis. opa transcripts are first detected in early stage 5 embryos in a 10 cell wide stripe at about 80% egg length. Expression extends posteriorly and becomes uniform over the region from 20% to 80% egg length with the posterior border being more sharply defined than the anterior border. Expression continues in this domain through gastrulation. During germ band extension, a pattern of 14 stripes develops over a low background level of expression. (Benedyk et al., 1994) opa is expressed in a broad domain encompassing the entire segmented region of the embryo during stages 5-9. At stage 5, expression extends from 16%-78% egg length in ventrally located cells fated to become mesoderm and in dorsally located ectodermal cells. During gastrulation, expression becomes periodic, showing 14 stripes. By late stage 9, expression is no longer seen in the ectoderm or the mesoderm with the exception of a small number of cells in the neurogenic region, the tip of the germ band, and the head. Late in stage 11, opa expression initiates in the visceral mesoderm in seven discrete clusters of cells, arranged in two groups. In stage 12, expression becomes continuous in each region yielding at stage 13, two distinct domains of expression in the visceral mesoderm. The anterior domain corresponds to parasegment 5 and the posterior domain to parasegments 9-12. During stage 15, the 2nd midgut constriction forms between the opa expression domains. At stage 16, the first midgut constriction forms at the posterior boundary of the anterior opa expression domain and the third midgut constriction forms within the anterior margin of the posterior opa expression domain. (Cimbora and Sakonju, 1995)
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
immunolocalization Stage Tissue/Position (including subcellular localization) Reference embryonic stage 5 -- 7   organism | 20-80% egg length   (Benedyk et al., 1994) embryonic stage 7   organism | striped   (Benedyk et al., 1994)
Additional Descriptive Data
	opa protein ispresent in a block from 20% to 80% egg length during cellularization andinto gastrulation. During germ band extension, a pattern of 14 stripesdevelops over a low background level of expression. (Benedyk et al., 1994)
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
nucleus inferred from direct assay (Benedyk et al., 1994)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: larval central nervous system. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    313.2 Larval Midgut    18.8 Larval Hindgut    5.4 Larval Malpighian Tubules    5 Larval Fat Body    1.9 Larval Salivary Gland    4.8 Larval Trachea    15.075 Larval Carcass    26.175 Adult Head    31.2 Adult Eye    6.425 Adult Brain    78.7 Adult Thoracic-Abdominal Ganglion    52.5 Adult Crop    5.5 Adult Midgut    13.7 Adult Hindgut    4.3 Adult Malpighian Tubules    4.1 Adult Fat Body    11.7 Adult Salivary Gland    11.7 Adult Heart    3.05 Adult VirginFemale Spermatheca    5.2 Adult InseminatedFemale Spermatheca    3.6 Adult Ovary    1.9 Adult Testis    0.6 Adult Male Accessory Gland    4.8 Adult Carcass    17 Expression Level Scale  None   Low   Moderate  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    313.2 Larval Midgut    18.8 Larval Hindgut    5.4 Larval Malpighian Tubules    5 Larval Fat Body    1.9 Larval Salivary Gland    4.8 Larval Trachea    15.075 Larval Carcass    26.175 Adult Head    31.2 Adult Eye    6.425 Adult Brain    78.7 Adult Thoracic-Abdominal Ganglion    52.5 Adult Crop    5.5 Adult Midgut    13.7 Adult Hindgut    4.3 Adult Malpighian Tubules    4.1 Adult Fat Body    11.7 Adult Salivary Gland    11.7 Adult Heart    3.05 Adult VirginFemale Spermatheca    5.2 Adult InseminatedFemale Spermatheca    3.6 Adult Ovary    1.9 Adult Testis    0.6 Adult Male Accessory Gland    4.8 Adult Carcass    17 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    313.2 Larval Midgut    18.8 Larval Hindgut    5.4 Larval Malpighian Tubules    5 Larval Fat Body    1.9 Larval Salivary Gland    4.8 Larval Trachea    15.075 Larval Carcass    26.175 Adult Head    31.2 Adult Eye    6.425 Adult Brain    78.7 Adult Thoracic-Abdominal Ganglion    52.5 Adult Crop    5.5 Adult Midgut    13.7 Adult Hindgut    4.3 Adult Malpighian Tubules    4.1 Adult Fat Body    11.7 Adult Salivary Gland    11.7 Adult Heart    3.05 Adult VirginFemale Spermatheca    5.2 Adult InseminatedFemale Spermatheca    3.6 Adult Ovary    1.9 Adult Testis    0.6 Adult Male Accessory Gland    4.8 Adult Carcass    17 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    313.2 Larval Midgut    18.8 Larval Hindgut    5.4 Larval Malpighian Tubules    5 Larval Fat Body    1.9 Larval Salivary Gland    4.8 Larval Trachea    15.075 Larval Carcass    26.175 Adult Head    31.2 Adult Eye    6.425 Adult Brain    78.7 Adult Thoracic-Abdominal Ganglion    52.5 Adult Crop    5.5 Adult Midgut    13.7 Adult Hindgut    4.3 Adult Malpighian Tubules    4.1 Adult Fat Body    11.7 Adult Salivary Gland    11.7 Adult Heart    3.05 Adult VirginFemale Spermatheca    5.2 Adult InseminatedFemale Spermatheca    3.6 Adult Ovary    1.9 Adult Testis    0.6 Adult Male Accessory Gland    4.8 Adult Carcass    17 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    313.2 Larval Midgut    18.8 Larval Hindgut    5.4 Larval Malpighian Tubules    5 Larval Fat Body    1.9 Larval Salivary Gland    4.8 Larval Trachea    15.075 Larval Carcass    26.175 Adult Head    31.2 Adult Eye    6.425 Adult Brain    78.7 Adult Thoracic-Abdominal Ganglion    52.5 Adult Crop    5.5 Adult Midgut    13.7 Adult Hindgut    4.3 Adult Malpighian Tubules    4.1 Adult Fat Body    11.7 Adult Salivary Gland    11.7 Adult Heart    3.05 Adult VirginFemale Spermatheca    5.2 Adult InseminatedFemale Spermatheca    3.6 Adult Ovary    1.9 Adult Testis    0.6 Adult Male Accessory Gland    4.8 Adult Carcass    17 Expression Level Scale  None   Low   Moderate   High  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    313.2 Larval Midgut    18.8 Larval Hindgut    5.4 Larval Malpighian Tubules    5 Larval Fat Body    1.9 Larval Salivary Gland    4.8 Larval Trachea    15.075 Larval Carcass    26.175 Adult Head    31.2 Adult Eye    6.425 Adult Brain    78.7 Adult Thoracic-Abdominal Ganglion    52.5 Adult Crop    5.5 Adult Midgut    13.7 Adult Hindgut    4.3 Adult Malpighian Tubules    4.1 Adult Fat Body    11.7 Adult Salivary Gland    11.7 Adult Heart    3.05 Adult VirginFemale Spermatheca    5.2 Adult InseminatedFemale Spermatheca    3.6 Adult Ovary    1.9 Adult Testis    0.6 Adult Male Accessory Gland    4.8 Adult Carcass    17 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    313.2 Larval Midgut    18.8 Larval Hindgut    5.4 Larval Malpighian Tubules    5 Larval Fat Body    1.9 Larval Salivary Gland    4.8 Larval Trachea    15.075 Larval Carcass    26.175 Adult Head    31.2 Adult Eye    6.425 Adult Brain    78.7 Adult Thoracic-Abdominal Ganglion    52.5 Adult Crop    5.5 Adult Midgut    13.7 Adult Hindgut    4.3 Adult Malpighian Tubules    4.1 Adult Fat Body    11.7 Adult Salivary Gland    11.7 Adult Heart    3.05 Adult VirginFemale Spermatheca    5.2 Adult InseminatedFemale Spermatheca    3.6 Adult Ovary    1.9 Adult Testis    0.6 Adult Male Accessory Gland    4.8 Adult Carcass    17 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    313.2 Larval Midgut    18.8 Larval Hindgut    5.4 Larval Malpighian Tubules    5 Larval Fat Body    1.9 Larval Salivary Gland    4.8 Larval Trachea    15.075 Larval Carcass    26.175 Adult Head    31.2 Adult Eye    6.425 Adult Brain    78.7 Adult Thoracic-Abdominal Ganglion    52.5 Adult Crop    5.5 Adult Midgut    13.7 Adult Hindgut    4.3 Adult Malpighian Tubules    4.1 Adult Fat Body    11.7 Adult Salivary Gland    11.7 Adult Heart    3.05 Adult VirginFemale Spermatheca    5.2 Adult InseminatedFemale Spermatheca    3.6 Adult Ovary    1.9 Adult Testis    0.6 Adult Male Accessory Gland    4.8 Adult Carcass    17 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    31.2   NA  Eye    6.425   NA  Brain    78.7   313.2  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    52.5   NA  Crop    5.5   18.8  Midgut    13.7   5.4  Hindgut    4.3   5  Malpighian Tubules    4.1   1.9  Fat Body    11.7   4.8  Salivary Gland    no informative data   NA  Heart    3.05   15.075  Trachea    NA   NA  VirginFemale Spermatheca    5.2   NA  InseminatedFemale Spermatheca    3.6   NA  Ovary    1.9   NA  Testis    0.6   NA  Male Accessory Gland    4.8   26.175  Carcass    no informative data FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    12 central nervous system, larvae L3    22 central nervous system, pupae P8    4 head, virgin 1-day female    2 head, virgin 4-day female    1 head, virgin 20-day female    1 head, mated 1-day female    2 head, mated 4-day female    1 head, mated 20-day female    2 head, mated 1-day male    3 head, mated 4-day male    3 head, mated 20-day male    2 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    1 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    1 fat body, pupae P8    0 carcass, larvae L3 wandering    6 carcass, 1-day adult    0 carcass, 4-day adult    1 carcass, 20-day adult    0 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    0 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    12 central nervous system, larvae L3    22 central nervous system, pupae P8    4 head, virgin 1-day female    2 head, virgin 4-day female    1 head, virgin 20-day female    1 head, mated 1-day female    2 head, mated 4-day female    1 head, mated 20-day female    2 head, mated 1-day male    3 head, mated 4-day male    3 head, mated 20-day male    2 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    1 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    1 fat body, pupae P8    0 carcass, larvae L3 wandering    6 carcass, 1-day adult    0 carcass, 4-day adult    1 carcass, 20-day adult    0 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    0 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    12 central nervous system, larvae L3    22 central nervous system, pupae P8    4 head, virgin 1-day female    2 head, virgin 4-day female    1 head, virgin 20-day female    1 head, mated 1-day female    2 head, mated 4-day female    1 head, mated 20-day female    2 head, mated 1-day male    3 head, mated 4-day male    3 head, mated 20-day male    2 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    1 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    1 fat body, pupae P8    0 carcass, larvae L3 wandering    6 carcass, 1-day adult    0 carcass, 4-day adult    1 carcass, 20-day adult    0 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    12 central nervous system, larvae L3    22 central nervous system, pupae P8    4 head, virgin 1-day female    2 head, virgin 4-day female    1 head, virgin 20-day female    1 head, mated 1-day female    2 head, mated 4-day female    1 head, mated 20-day female    2 head, mated 1-day male    3 head, mated 4-day male    3 head, mated 20-day male    2 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    1 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    1 fat body, pupae P8    0 carcass, larvae L3 wandering    6 carcass, 1-day adult    0 carcass, 4-day adult    1 carcass, 20-day adult    0 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    0 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    12 central nervous system, larvae L3    22 central nervous system, pupae P8    4 head, virgin 1-day female    2 head, virgin 4-day female    1 head, virgin 20-day female    1 head, mated 1-day female    2 head, mated 4-day female    1 head, mated 20-day female    2 head, mated 1-day male    3 head, mated 4-day male    3 head, mated 20-day male    2 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    1 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    1 fat body, pupae P8    0 carcass, larvae L3 wandering    6 carcass, 1-day adult    0 carcass, 4-day adult    1 carcass, 20-day adult    0 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    0 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    12 central nervous system, larvae L3    22 central nervous system, pupae P8    4 head, virgin 1-day female    2 head, virgin 4-day female    1 head, virgin 20-day female    1 head, mated 1-day female    2 head, mated 4-day female    1 head, mated 20-day female    2 head, mated 1-day male    3 head, mated 4-day male    3 head, mated 20-day male    2 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    1 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    1 fat body, pupae P8    0 carcass, larvae L3 wandering    6 carcass, 1-day adult    0 carcass, 4-day adult    1 carcass, 20-day adult    0 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    0 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    12 central nervous system, larvae L3    22 central nervous system, pupae P8    4 head, virgin 1-day female    2 head, virgin 4-day female    1 head, virgin 20-day female    1 head, mated 1-day female    2 head, mated 4-day female    1 head, mated 20-day female    2 head, mated 1-day male    3 head, mated 4-day male    3 head, mated 20-day male    2 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    1 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    1 fat body, pupae P8    0 carcass, larvae L3 wandering    6 carcass, 1-day adult    0 carcass, 4-day adult    1 carcass, 20-day adult    0 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    12 central nervous system, larvae L3    22 central nervous system, pupae P8    4 head, virgin 1-day female    2 head, virgin 4-day female    1 head, virgin 20-day female    1 head, mated 1-day female    2 head, mated 4-day female    1 head, mated 20-day female    2 head, mated 1-day male    3 head, mated 4-day male    3 head, mated 20-day male    2 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    1 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    1 fat body, pupae P8    0 carcass, larvae L3 wandering    6 carcass, 1-day adult    0 carcass, 4-day adult    1 carcass, 20-day adult    0 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of extremely low expression. Peak expression observed within 00-06 hour embryonic stages. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    3 embryo 02-04hr    90 embryo 04-06hr    31 embryo 06-08hr    18 embryo 08-10hr    22 embryo 10-12hr    15 embryo 12-14hr    13 embryo 14-16hr    10 embryo 16-18hr    6 embryo 18-20hr    7 embryo 20-22hr    5 embryo 22-24hr    4 larva L1    4 larva L2    1 larva L3 12hr old    1 larva L3 puffstage 1-2    2 larva L3 puffstage 3-6    3 larva L3 puffstage 7-9    4 white prepupae new    4 white prepupae 12hr    3 white prepupae 24hr    5 pupae 2d postWPP    3 pupae 3d postWPP    1 pupae 4d postWPP    1 adult male 01day    1 adult male 05day    1 adult male 30day    1 adult female 01day    1 adult female 05day    0 adult female 30day    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    3 embryo 02-04hr  (90) embryo 04-06hr  (31) embryo 06-08hr    18 embryo 08-10hr    22 embryo 10-12hr    15 embryo 12-14hr    13 embryo 14-16hr    10 embryo 16-18hr    6 embryo 18-20hr    7 embryo 20-22hr    5 embryo 22-24hr    4 larva L1    4 larva L2    1 larva L3 12hr old    1 larva L3 puffstage 1-2    2 larva L3 puffstage 3-6    3 larva L3 puffstage 7-9    4 white prepupae new    4 white prepupae 12hr    3 white prepupae 24hr    5 pupae 2d postWPP    3 pupae 3d postWPP    1 pupae 4d postWPP    1 adult male 01day    1 adult male 05day    1 adult male 30day    1 adult female 01day    1 adult female 05day    0 adult female 30day    0 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    3 embryo 02-04hr    90 embryo 04-06hr    31 embryo 06-08hr    18 embryo 08-10hr    22 embryo 10-12hr    15 embryo 12-14hr    13 embryo 14-16hr    10 embryo 16-18hr    6 embryo 18-20hr    7 embryo 20-22hr    5 embryo 22-24hr    4 larva L1    4 larva L2    1 larva L3 12hr old    1 larva L3 puffstage 1-2    2 larva L3 puffstage 3-6    3 larva L3 puffstage 7-9    4 white prepupae new    4 white prepupae 12hr    3 white prepupae 24hr    5 pupae 2d postWPP    3 pupae 3d postWPP    1 pupae 4d postWPP    1 adult male 01day    1 adult male 05day    1 adult male 30day    1 adult female 01day    1 adult female 05day    0 adult female 30day    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    3 embryo 02-04hr    90 embryo 04-06hr    31 embryo 06-08hr    18 embryo 08-10hr    22 embryo 10-12hr    15 embryo 12-14hr    13 embryo 14-16hr    10 embryo 16-18hr    6 embryo 18-20hr    7 embryo 20-22hr    5 embryo 22-24hr    4 larva L1    4 larva L2    1 larva L3 12hr old    1 larva L3 puffstage 1-2    2 larva L3 puffstage 3-6    3 larva L3 puffstage 7-9    4 white prepupae new    4 white prepupae 12hr    3 white prepupae 24hr    5 pupae 2d postWPP    3 pupae 3d postWPP    1 pupae 4d postWPP    1 adult male 01day    1 adult male 05day    1 adult male 30day    1 adult female 01day    1 adult female 05day    0 adult female 30day    0 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    3 embryo 02-04hr    90 embryo 04-06hr    31 embryo 06-08hr    18 embryo 08-10hr    22 embryo 10-12hr    15 embryo 12-14hr    13 embryo 14-16hr    10 embryo 16-18hr    6 embryo 18-20hr    7 embryo 20-22hr    5 embryo 22-24hr    4 larva L1    4 larva L2    1 larva L3 12hr old    1 larva L3 puffstage 1-2    2 larva L3 puffstage 3-6    3 larva L3 puffstage 7-9    4 white prepupae new    4 white prepupae 12hr    3 white prepupae 24hr    5 pupae 2d postWPP    3 pupae 3d postWPP    1 pupae 4d postWPP    1 adult male 01day    1 adult male 05day    1 adult male 30day    1 adult female 01day    1 adult female 05day    0 adult female 30day    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    3 embryo 02-04hr  (90) embryo 04-06hr  31 embryo 06-08hr    18 embryo 08-10hr    22 embryo 10-12hr    15 embryo 12-14hr    13 embryo 14-16hr    10 embryo 16-18hr    6 embryo 18-20hr    7 embryo 20-22hr    5 embryo 22-24hr    4 larva L1    4 larva L2    1 larva L3 12hr old    1 larva L3 puffstage 1-2    2 larva L3 puffstage 3-6    3 larva L3 puffstage 7-9    4 white prepupae new    4 white prepupae 12hr    3 white prepupae 24hr    5 pupae 2d postWPP    3 pupae 3d postWPP    1 pupae 4d postWPP    1 adult male 01day    1 adult male 05day    1 adult male 30day    1 adult female 01day    1 adult female 05day    0 adult female 30day    0 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    3 embryo 02-04hr    90 embryo 04-06hr    31 embryo 06-08hr    18 embryo 08-10hr    22 embryo 10-12hr    15 embryo 12-14hr    13 embryo 14-16hr    10 embryo 16-18hr    6 embryo 18-20hr    7 embryo 20-22hr    5 embryo 22-24hr    4 larva L1    4 larva L2    1 larva L3 12hr old    1 larva L3 puffstage 1-2    2 larva L3 puffstage 3-6    3 larva L3 puffstage 7-9    4 white prepupae new    4 white prepupae 12hr    3 white prepupae 24hr    5 pupae 2d postWPP    3 pupae 3d postWPP    1 pupae 4d postWPP    1 adult male 01day    1 adult male 05day    1 adult male 30day    1 adult female 01day    1 adult female 05day    0 adult female 30day    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    3 embryo 02-04hr    90 embryo 04-06hr    31 embryo 06-08hr    18 embryo 08-10hr    22 embryo 10-12hr    15 embryo 12-14hr    13 embryo 14-16hr    10 embryo 16-18hr    6 embryo 18-20hr    7 embryo 20-22hr    5 embryo 22-24hr    4 larva L1    4 larva L2    1 larva L3 12hr old    1 larva L3 puffstage 1-2    2 larva L3 puffstage 3-6    3 larva L3 puffstage 7-9    4 white prepupae new    4 white prepupae 12hr    3 white prepupae 24hr    5 pupae 2d postWPP    3 pupae 3d postWPP    1 pupae 4d postWPP    1 adult male 01day    1 adult male 05day    1 adult male 30day    1 adult female 01day    1 adult female 05day    0 adult female 30day    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    3 cold shock, 4-day adult    3 heat shock, 4-day adult    1 Cadmium 50 mM 6 hrs, larvae L3    1 Cadmium 50 mM 12 hrs, larvae L3    1 Cadmium 50 mM 48 hrs, 4-day adult    1 Cadmium 100 mM 48 hrs, 4-day adult    1 Copper 0.5 mM 12 hrs, larvae L3    1 Copper 15 mM 48 hrs, 4-day adult    1 Zinc 5 mM 12 hrs, larvae L3    2 Zinc 4.5 mM 48 hrs, 4-day adult    0 Ethanol 2.5% 3 hrs, larvae L3    0 Ethanol 5% 3 hrs, larvae L3    1 Ethanol 10% 3 hrs, larvae L3    1 Caffeine 1.5 mg/ml 4 hrs, larvae L3    1 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    0 Caffeine 25 mg/ml 48 hrs, 4-day adult    2 Paraquat 5 mM 48 hrs, 4-day adult    0 Paraquat 10 mM 48 hrs, 4-day adult    1 Rotenone 2 μg 12 hrs, larvae L3    1 Rotenone 8 μg 12 hrs, larvae L3    2 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    3 cold shock, 4-day adult    3 heat shock, 4-day adult    1 Cadmium 50 mM 6 hrs, larvae L3    1 Cadmium 50 mM 12 hrs, larvae L3    1 Cadmium 50 mM 48 hrs, 4-day adult    1 Cadmium 100 mM 48 hrs, 4-day adult    1 Copper 0.5 mM 12 hrs, larvae L3    1 Copper 15 mM 48 hrs, 4-day adult    1 Zinc 5 mM 12 hrs, larvae L3    2 Zinc 4.5 mM 48 hrs, 4-day adult    0 Ethanol 2.5% 3 hrs, larvae L3    0 Ethanol 5% 3 hrs, larvae L3    1 Ethanol 10% 3 hrs, larvae L3    1 Caffeine 1.5 mg/ml 4 hrs, larvae L3    1 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    0 Caffeine 25 mg/ml 48 hrs, 4-day adult    2 Paraquat 5 mM 48 hrs, 4-day adult    0 Paraquat 10 mM 48 hrs, 4-day adult    1 Rotenone 2 μg 12 hrs, larvae L3    1 Rotenone 8 μg 12 hrs, larvae L3    2 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    3 cold shock, 4-day adult    3 heat shock, 4-day adult    1 Cadmium 50 mM 6 hrs, larvae L3    1 Cadmium 50 mM 12 hrs, larvae L3    1 Cadmium 50 mM 48 hrs, 4-day adult    1 Cadmium 100 mM 48 hrs, 4-day adult    1 Copper 0.5 mM 12 hrs, larvae L3    1 Copper 15 mM 48 hrs, 4-day adult    1 Zinc 5 mM 12 hrs, larvae L3    2 Zinc 4.5 mM 48 hrs, 4-day adult    0 Ethanol 2.5% 3 hrs, larvae L3    0 Ethanol 5% 3 hrs, larvae L3    1 Ethanol 10% 3 hrs, larvae L3    1 Caffeine 1.5 mg/ml 4 hrs, larvae L3    1 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    0 Caffeine 25 mg/ml 48 hrs, 4-day adult    2 Paraquat 5 mM 48 hrs, 4-day adult    0 Paraquat 10 mM 48 hrs, 4-day adult    1 Rotenone 2 μg 12 hrs, larvae L3    1 Rotenone 8 μg 12 hrs, larvae L3    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    3 cold shock, 4-day adult    3 heat shock, 4-day adult    1 Cadmium 50 mM 6 hrs, larvae L3    1 Cadmium 50 mM 12 hrs, larvae L3    1 Cadmium 50 mM 48 hrs, 4-day adult    1 Cadmium 100 mM 48 hrs, 4-day adult    1 Copper 0.5 mM 12 hrs, larvae L3    1 Copper 15 mM 48 hrs, 4-day adult    1 Zinc 5 mM 12 hrs, larvae L3    2 Zinc 4.5 mM 48 hrs, 4-day adult    0 Ethanol 2.5% 3 hrs, larvae L3    0 Ethanol 5% 3 hrs, larvae L3    1 Ethanol 10% 3 hrs, larvae L3    1 Caffeine 1.5 mg/ml 4 hrs, larvae L3    1 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    0 Caffeine 25 mg/ml 48 hrs, 4-day adult    2 Paraquat 5 mM 48 hrs, 4-day adult    0 Paraquat 10 mM 48 hrs, 4-day adult    1 Rotenone 2 μg 12 hrs, larvae L3    1 Rotenone 8 μg 12 hrs, larvae L3    2 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    3 cold shock, 4-day adult    3 heat shock, 4-day adult    1 Cadmium 50 mM 6 hrs, larvae L3    1 Cadmium 50 mM 12 hrs, larvae L3    1 Cadmium 50 mM 48 hrs, 4-day adult    1 Cadmium 100 mM 48 hrs, 4-day adult    1 Copper 0.5 mM 12 hrs, larvae L3    1 Copper 15 mM 48 hrs, 4-day adult    1 Zinc 5 mM 12 hrs, larvae L3    2 Zinc 4.5 mM 48 hrs, 4-day adult    0 Ethanol 2.5% 3 hrs, larvae L3    0 Ethanol 5% 3 hrs, larvae L3    1 Ethanol 10% 3 hrs, larvae L3    1 Caffeine 1.5 mg/ml 4 hrs, larvae L3    1 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    0 Caffeine 25 mg/ml 48 hrs, 4-day adult    2 Paraquat 5 mM 48 hrs, 4-day adult    0 Paraquat 10 mM 48 hrs, 4-day adult    1 Rotenone 2 μg 12 hrs, larvae L3    1 Rotenone 8 μg 12 hrs, larvae L3    2 Expression Level Scale  Very low   Low   Moderate  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    3 cold shock, 4-day adult    3 heat shock, 4-day adult    1 Cadmium 50 mM 6 hrs, larvae L3    1 Cadmium 50 mM 12 hrs, larvae L3    1 Cadmium 50 mM 48 hrs, 4-day adult    1 Cadmium 100 mM 48 hrs, 4-day adult    1 Copper 0.5 mM 12 hrs, larvae L3    1 Copper 15 mM 48 hrs, 4-day adult    1 Zinc 5 mM 12 hrs, larvae L3    2 Zinc 4.5 mM 48 hrs, 4-day adult    0 Ethanol 2.5% 3 hrs, larvae L3    0 Ethanol 5% 3 hrs, larvae L3    1 Ethanol 10% 3 hrs, larvae L3    1 Caffeine 1.5 mg/ml 4 hrs, larvae L3    1 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    0 Caffeine 25 mg/ml 48 hrs, 4-day adult    2 Paraquat 5 mM 48 hrs, 4-day adult    0 Paraquat 10 mM 48 hrs, 4-day adult    1 Rotenone 2 μg 12 hrs, larvae L3    1 Rotenone 8 μg 12 hrs, larvae L3    2 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    3 cold shock, 4-day adult    3 heat shock, 4-day adult    1 Cadmium 50 mM 6 hrs, larvae L3    1 Cadmium 50 mM 12 hrs, larvae L3    1 Cadmium 50 mM 48 hrs, 4-day adult    1 Cadmium 100 mM 48 hrs, 4-day adult    1 Copper 0.5 mM 12 hrs, larvae L3    1 Copper 15 mM 48 hrs, 4-day adult    1 Zinc 5 mM 12 hrs, larvae L3    2 Zinc 4.5 mM 48 hrs, 4-day adult    0 Ethanol 2.5% 3 hrs, larvae L3    0 Ethanol 5% 3 hrs, larvae L3    1 Ethanol 10% 3 hrs, larvae L3    1 Caffeine 1.5 mg/ml 4 hrs, larvae L3    1 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    0 Caffeine 25 mg/ml 48 hrs, 4-day adult    2 Paraquat 5 mM 48 hrs, 4-day adult    0 Paraquat 10 mM 48 hrs, 4-day adult    1 Rotenone 2 μg 12 hrs, larvae L3    1 Rotenone 8 μg 12 hrs, larvae L3    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    3 cold shock, 4-day adult    3 heat shock, 4-day adult    1 Cadmium 50 mM 6 hrs, larvae L3    1 Cadmium 50 mM 12 hrs, larvae L3    1 Cadmium 50 mM 48 hrs, 4-day adult    1 Cadmium 100 mM 48 hrs, 4-day adult    1 Copper 0.5 mM 12 hrs, larvae L3    1 Copper 15 mM 48 hrs, 4-day adult    1 Zinc 5 mM 12 hrs, larvae L3    2 Zinc 4.5 mM 48 hrs, 4-day adult    0 Ethanol 2.5% 3 hrs, larvae L3    0 Ethanol 5% 3 hrs, larvae L3    1 Ethanol 10% 3 hrs, larvae L3    1 Caffeine 1.5 mg/ml 4 hrs, larvae L3    1 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    0 Caffeine 25 mg/ml 48 hrs, 4-day adult    2 Paraquat 5 mM 48 hrs, 4-day adult    0 Paraquat 10 mM 48 hrs, 4-day adult    1 Rotenone 2 μg 12 hrs, larvae L3    1 Rotenone 8 μg 12 hrs, larvae L3    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010, Graveley et al., 2011) mE2_34_mRNA_expression_cluster_11 mE1_20_mRNA_expression_cluster_06
External Data & Images
Linkouts	BDGP expression data • CG1133 LD30441 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0003002 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG1133-RA FlyExpress - Embryonic expression images (BDGP data) • Show all FlyExpress processed images for opa Stages(s) 1-3 Stages(s) 4-6 Stages(s) 7-8
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal | embryonic stage (with opa7) opa12.3 opa32.3 opaM opaQ lethal | embryonic stage (with opa8) opa12.3 opa32.3 opaM opaQ lethal | embryonic stage (with opa12.3) opa7 opa8 lethal | embryonic stage (with opa32.3) opa7 opa8 lethal | embryonic stage (with opaM) opa7 opa8 lethal | embryonic stage (with opaQ) opa7 opa8 lethal | embryonic stage | pair rule expression pattern | recessive opaunspecified lethal | embryonic stage | recessive opa1 opa2 opa12.3 opa32.3 opaM opaQ lethal | recessive opaC418 opaC974 opal12 opal27 lethal | recessive | heat sensitive opatsl25 Other Phenotypes Allele pair rule phenotype | embryonic stage oparSS visible, with Scer\GAL4ey.PH opaScer\UAS.cLa visible | heat sensitive (with opa12.3) opatsl25 visible | heat sensitive (with opatsl25) opa12.3 visible | somatic clone opa7 Phenotype manifest in Allele adult antennal segment | supernumerary, with Scer\GAL4ey.PH opaScer\UAS.cLa adult head | somatic clone | ventral opa7 adult head | ventral | heat sensitive (with opa12.3) opatsl25 adult head | ventral | heat sensitive (with opatsl25) opa12.3 antenna | heat sensitive (with opa12.3) opatsl25 antenna | heat sensitive (with opatsl25) opa12.3 antenna | somatic clone opa7 antennal disc, with Scer\GAL4ey.PH opaScer\UAS.cLa arista | supernumerary, with Scer\GAL4ey.PH opaScer\UAS.cLa denticle belt opa5 opa8 opaIIC71 embryonic/first instar larval cuticle opa1 opa2 embryonic/larval cuticle oparSS embryonic maxillary segment opa1 embryonic segment opa1 opa2 opaB3-2 eye, with Scer\GAL4ey.PH opaScer\UAS.cLa eye | heat sensitive (with opa12.3) opatsl25 eye | heat sensitive (with opatsl25) opa12.3 eye | somatic clone opa7 eye disc, with Scer\GAL4ey.PH opaScer\UAS.cLa fat body/gonad primordium opaunspecified gena | heat sensitive (with opa12.3) opatsl25 gena | heat sensitive (with opatsl25) opa12.3 gonadal sheath proper primordium opaunspecified heart primordium opadsRNA.cKa opadsRNA.si.cKa maxillary palpus | heat sensitive (with opa12.3) opatsl25 maxillary palpus | heat sensitive (with opatsl25) opa12.3 maxillary palpus | somatic clone opa7 maxillary palpus | supernumerary, with Scer\GAL4ey.PH opaScer\UAS.cLa midgut constriction opa1 opa2 opaB3-2 rostral membrane | somatic clone opa7 vibrissae | heat sensitive (with opa12.3) opatsl25 vibrissae | heat sensitive (with opatsl25) opa12.3 vibrissae | somatic clone opa7
Classical Alleles ( 31 )
For All Classical Alleles Show
Allele of opa Class Mutagen Stocks Known lesion opa1 amorphic allele - genetic evidence ethyl methanesulfonate 3 Yes opa8 loss of function allele ethyl methanesulfonate 3 -- opa5 ethyl methanesulfonate 1 -- opatsl25 1 -- opa2 amorphic allele - genetic evidence ethyl methanesulfonate 0 Yes opa12.3 0 -- opa32.3 0 -- opa3 ethyl methanesulfonate 0 -- opa3D246 Delta2-3 0 Yes opa4 ethyl methanesulfonate 0 -- opa5H57 0 -- opa6 ethyl methanesulfonate 0 -- opa7 loss of function allele ethyl methanesulfonate 0 -- opa9 ethyl methanesulfonate 0 -- opaA3 ethyl methanesulfonate 0 -- opaB28 ethyl methanesulfonate 0 Yes opaB3-2 Delta2-3 0 Yes opaC418 0 -- opaC974 0 -- opaGAL4 P-element activity 0 Yes opaIIC71 0 -- opal12 0 -- opal27 0 -- opaM 0 -- opaQ 0 -- oparSS 0 -- opaSIE-19 ethyl methanesulfonate 0 Yes opaSIE-24 ethyl methanesulfonate 0 Yes opaSJE-2 ethyl methanesulfonate 0 -- opaSKE-5 ethyl methanesulfonate 0 Yes opaunspecified ethyl methanesulfonate 0 --
Alleles Carried on Transgenic Constructs ( 12 )
For All Alleles Carried on Transgenic Constructs Show
Allele of opa Class Mutagen Stocks Known lesion opaHMS01185 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes opaKK108975 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes opacBa in vitro construct 0 Yes opadsRNA.103-1124 in vitro construct - RNAi 0 Yes opadsRNA.135-1156 in vitro construct - RNAi 0 Yes opadsRNA.cKa in vitro construct - RNAi 0 Yes opadsRNA.si.cKa in vitro construct - RNAi 0 Yes opahs.PB in vitro construct - regulatory fusion in vitro construct 0 Yes opahs.T:Ecol\dam,T:Hsap\MYC in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes opaNIG.1133R in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes opaScer\UAS.cLa in vitro construct - regulatory fusion 0 Yes opaScer\UAS.cSa in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(3R)6-7 (Megraw and Kaufman, 1998.10.2) Df(3R)63 (Benedyk et al., 1994) Df(3R)107 (Megraw and Kaufman, 1998.10.2) Df(3R)110 (Megraw and Kaufman, 1998.10.2, Colas et al., 1995) Df(3R)ED5066 (Roote, 2004.7.20) Df(3R)ED5071 (Roote, 2004.7.20, Ryder and Roote, 2004.11.10) Df(3R)ED5095 (Ryder and Roote, 2004.11.10) Df(3R)ED5138 (Roote, 2004.7.20, Ryder and Roote, 2004.11.10) Df(3R)ED5142 (Ryder and Roote, 2004.11.10) Df(3R)opaB3-2 (Cimbora and Sakonju, 1995) Df(3R)Z1 (Megraw and Kaufman, 1998.10.2, Benedyk et al., 1994) Ts(YSt;3Lt)J17+Ts(YSt;3Rt)D107 (Jurgens et al., 1984)
Not disrupted in	Df(3R)3-4 (Megraw and Kaufman, 1998.10.2)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data reporter construct P{opa-lacZ.01} No P{opa-lacZ.02} No P{opa-lacZ.03} No P{opa-lacZ.04} No P{opa-lacZ.05} No UAS construct P{KK108975} NA P{NIG.1133R} NA P{TRiP.HMS01185} NA P{UAS-opa.L} NA P{UAS-opa.VZ} NA heat-shock construct P{HSopaC} NA
Insertions
	Type of insertions Name Expression data insertion of enhancer trap P{lacZ-un1}opa3D246 No insertion of enhancer trap binary system P{GAL4}opaGAL4 No
Gene Ontology: Function, Process & Cellular Component ( 10 unique terms )
Terms Based on Experimental Evidence ( 5 terms )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
decapentaplegic signaling pathway inferred from mutant phenotype (Lee et al., 2007) eye-antennal disc morphogenesis inferred from mutant phenotype (Lee et al., 2007) germ cell migration inferred from mutant phenotype (Moore et al., 1998) midgut development inferred from expression pattern AND inferred from mutant phenotype (Cimbora and Sakonju, 1995)
Cellular Component
CV term Evidence References
nucleus inferred from direct assay (Benedyk et al., 1994)
Terms Based on Predictions or Assertions ( 6 terms )
Molecular Function
CV term Evidence References
nucleic acid binding inferred from electronic annotation with InterPro:IPR013087 (FlyBase Curators et al., 2004-) sequence-specific DNA binding transcription factor activity inferred from sequence or structural similarity with ci AND inferred from sequence or structural similarity with human GLI3 (Cimbora and Sakonju, 1995) inferred from sequence or structural similarity with UniProtKB:O95409 (FlyBase, 1992-) non-traceable author statement (Swiss-Prot Project Members, 1995.2.1) zinc ion binding inferred from electronic annotation with InterPro:IPR007087, InterPro:IPR015880 (FlyBase Curators et al., 2004-)
Biological Process
CV term Evidence References
periodic partitioning non-traceable author statement (Swiss-Prot Project Members, 1995.2.1) regulation of transcription from RNA polymerase II promoter inferred from sequence or structural similarity with UniProtKB:O95409 (FlyBase, 1992-)
Cellular Component
CV term Evidence References
nucleus inferred from sequence or structural similarity with UniProtKB:O95409 (FlyBase, 1992-) non-traceable author statement (Swiss-Prot Project Members, 1995.2.1)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions opa allele Gene References unspecified Psn (Mahoney et al., 2006) RpII140 (Parkhurst and Ish-Horowicz, 1991)
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 65820 DroID - A comprehensive database of gene and protein interactions. • FBgn0003002 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 40605 SignaLink - A protein-protein and protein-miRNA interaction database with multi-layered structure and multiple confidence scores. • P39768
Orthologs
OrthoDB Orthologs (58) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG6T1J6N Dipteran inclusive ortholog search EOG6XD40Z Insect inclusive ortholog search EOG612K2N Arthropod inclusive ortholog search EOG68GTKH Metazoa inclusive ortholog search EOG61GFZP
Orthologs in Drosophila Species (EOG6T1J6N)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\opa     Drosophila simulans   Dsim\GD19752 Y   Drosophila sechellia   Dsec\GM10780 Y   Drosophila yakuba   Dyak\GE25438 Y   Drosophila ananassae   Dana\GF18915 Y
Orthologs in non-Drosophila Dipterans (EOG6XD40Z)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL001344   Anopheles gambiae Malaria mosquito  Agam\AGAP001291   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ018949
Orthologs in non-Dipteran Insects (EOG612K2N)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\GB54250   Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG003326   Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH24917   Atta cephalotes Leafcutter ant  Acep\ACEP13418   Camponotus floridanus Florida carpenter ant  Cflo\CFLO24484   Linepithema humile Argentine ant  Lhum\LH19729   Pogonomyrmex barbatus Red harvester ant  Pbar\PB12056   Solenopsis invicta Red fire ant  Sinv\SINV14412   Acyrthosiphon pisum Pea aphid  Apim\ACYPI009007   Bombyx mori Silkmoth  Bmor\BGIBMGA007595   Pediculus humanus Human body louse  Phum\PHUM303860   Tribolium castaneum Red flour beetle  Tcas\TC010234
Orthologs in non-Insect Arthropods (EOG68GTKH)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\OPA   Daphnia pulex Water flea  Dpux\JGI_V11_102025
Orthologs in non-Arthropod Metazoa (EOG61GFZP)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Caenorhabditis elegans Nematode  Cele\ref-2 Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_028583gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_010542gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_017579gn Y Danio rerio Zebrafish  Drer\zic1 Y Danio rerio Zebrafish  Drer\zic2b Y Danio rerio Zebrafish  Drer\si:rp71-84k24.2 Y Danio rerio Zebrafish  Drer\zic5 Y Danio rerio Zebrafish  Drer\zic6 Y Danio rerio Zebrafish  Drer\zic2a Y Danio rerio Zebrafish  Drer\zic3 Y Danio rerio Zebrafish  Drer\zic4 Y Danio rerio Zebrafish  Drer\si:dkey-149i17.7 Y Danio rerio Zebrafish  Drer\gli1 Y Danio rerio Zebrafish  Drer\ENSDARG00000078388 Y Xenopus tropicalis Western clawed frog  Xtro\zic5 Y Xenopus tropicalis Western clawed frog  Xtro\zic4 Y Xenopus tropicalis Western clawed frog  Xtro\ENSXETG00000024432 Y Xenopus tropicalis Western clawed frog  Xtro\zic3 Y Xenopus tropicalis Western clawed frog  Xtro\gli1.1 Y Xenopus tropicalis Western clawed frog  Xtro\zic1 Y Gallus gallus Domestic chicken  Ggal\ZIC3 Y Gallus gallus Domestic chicken  Ggal\ZIC1 Y Gallus gallus Domestic chicken  Ggal\ZIC4 Y Mus musculus House mouse  Mmus\Zic3 Y Mus musculus House mouse  Mmus\Glis2 Y Mus musculus House mouse  Mmus\Zic4 Y Mus musculus House mouse  Mmus\ENSMUSG00000041703 Y Rattus norvegicus Norway rat  Rnor\Zic5 Y Rattus norvegicus Norway rat  Rnor\Zic2 Y Rattus norvegicus Norway rat  Rnor\Zic1 Y Rattus norvegicus Norway rat  Rnor\Glis2 Y Rattus norvegicus Norway rat  Rnor\Zic3 Y Homo sapiens Human  Hsap\ZIC5 Y Homo sapiens Human  Hsap\GLIS2 Y Homo sapiens Human  Hsap\ZIC4 Y
Human Orthologs (3)
Gene OMIM HGNC Hsap\ZIC5     Hsap\GLIS2     Hsap\ZIC4
AAA Orthologs (11) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD19752 Drosophila sechellia Dsec\GM10780 Drosophila erecta Dere\GG12590 Drosophila yakuba Dyak\GE25438 Drosophila ananassae Dana\GF18915 Drosophila pseudoobscura pseudoobscura Dpse\GA10924 Drosophila persimilis Dper\GL21621 Drosophila willistoni Dwil\GK13239 Drosophila virilis Dvir\GJ11051 Drosophila mojavensis Dmoj\GI10245 Drosophila grimshawi Dgri\GH23039
Stocks & Reagents
Stocks Listed in FlyBase ( 10 )
Bloomington	4820 opatsl25/TM3, Sb1 5334 P{ftz/lacC}1, opa5/TM3, Sb1 5335 P{ftz/lacC}1, opa8/TM3, Sb1 5340 P{ftz/lacC}4; opa8/TM3, Sb1 34706 y1 sc* v1; P{TRiP.HMS01185}attP2/TM3, Sb1 3312 h41 th1 st1 opa1 cu1 sr1 es ca1/TM3, Sb1
Kyoto	106972 h41 th1 st1 opa1 cu1 sr1 es ca1/TM3, Sb1 106928 ru1 h1 th1 st1 opa1 cu1 sr1 es ca1/TM3, Sb1 Ser1 101742 ru1 klar1 opa8 / TM3, y+ ru1 klar1 kniri-1 pp vvlsep Sb1 Ubxbx-34e es Ser1
VDRC	v101531 P{KK108975}VIE-260B
Genomic Clones ( 1 )
	BACR11M01 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 29 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	LD30441
Other clones	FI01113
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	RE49549
Other clones	69943 125686 214503.66 CK01.53B.E1 CK01.53B.F1 EK043017 EK043021 EK197553 EK221207 EP08610 RP01413 RP01445 RP01479 RP001001776 RP001007264 RP001011672 RP001018785 RP001019765 RP001024615 RP001029127 RP001032427 RP001040622 RP001042161 RP001047812 RP001055343 RP001056425
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0003002 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 40605
Antibody Information
	polyclonal (Benedyk et al., 1994)
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: opa CG1133 (Guan, 1999.11)
Source for database merge of
Additional comments
Other Comments
	One of 42 Drosophila genes identified as being most likely to reveal molecular and cellular mechanisms of nervous system development or plasticity relevant to human Mental Retardation disorders. (Inlow and Restifo, 2004) Mutants exhibit pair-rule pattern defects. (Moore et al., 1998) opa is required for formation of the three characteristic midgut constrictions. At the locations of the first and third constrictions, opa is positively regulated by Antp and abd-A, respectively, and negatively regulated by Ubx and dpp. (Cimbora and Sakonju, 1995) opa activity is essential for the appropriate level and timing of en and wg expression in all parasegments, but does not determine their restricted spatial domains of expression. (Benedyk et al., 1994) Deletes alternate metasegments, as defined by a line separating the anterior from the posterior parts of the anterior compartments; portions of denticle bands of T2, A1, A3, A5 and A7 and naked cuticle of T3, A2, A4 and A6 missing. (Lindsley and Zimm, 1992) Mutant analysis shows that wild type opa function is required to set up expression of ac in row B of the embryonic proneural cluster. (Skeath et al., 1992) Mutations in zygotic pair rule gene opa interact with RpII140wimp. (Parkhurst and Ish-Horowicz, 1991) The transition of prd RNA expression from the early 'pair-rule' pattern to the 'segment-polarity' pattern is regulated by the secondary pair-rule genes opa and odd. (Baumgartner and Noll, 1990) Genetic analysis demonstrates that opa is dispensable for efficient homeotic gene expression in the visceral mesoderm. (Tremml and Bienz, 1989) opa mutants display pair-rule segmentation defects. (Jurgens et al., 1984)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_079504 RefSeq (Proteins) • NP_524228 DDBJ / EMBL / GenBank • AA950584 AAA18958 AAB34592 AAF52084 AAF52084.1 AAK93207 AW943028 AY051783 S78339 U04435 Entrez Gene - A searchable database of RefSeq genes. • 40605 UniProtKB/Swiss-Prot • P39768
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Zinc finger C2H2-type/integrase DNA-binding domain (IPR013087) Zinc finger, C2H2-like (IPR015880) Zinc finger, C2H2 (IPR007087) BDGP expression data - Patterns of gene expression in Drosophila embryogenesis • CG1133 LD30441
Linkouts
	BioGRID - A database of protein and genetic interactions • 65820 DroID - A comprehensive database of gene and protein interactions. • FBgn0003002 DRSC - Results from RNAi screens. • FBgn0003002 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0003002 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG1133-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0003002 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 40605 Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution • /segment/oddpair.htm InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 40605 modMine - Data generated by the modENCODE project. • FBgn0003002 SignaLink - A protein-protein and protein-miRNA interaction database with multi-layered structure and multiple confidence scores. • P39768
Synonyms & Secondary IDs ( 8 )
Reported As
Symbol Synonym	CG1133 (Lu et al., 2009, Keleman et al., 2009.8.5, Ni et al., 2010.12.1) opa (Tucker and Chiquet-Ehrismann, 2006, Moorman et al., 2006, Moorman et al., 2006, Jacobsen et al., 2006, Sandmann et al., 2007, Hazelett et al., 2012, Lee et al., 2007, Sen et al., 2008, Wang et al., 2007, Kaplan et al., 2011, Vanderzwan-Butler et al., 2007, Harrison et al., 2011, Zheng et al., 2011, Liu et al., 2009, Lu et al., 2009, Grad et al., 2004, Walrad et al., 2010, Sen et al., 2010, Walrad et al., 2011, Prazak et al., 2010, Kazemian et al., 2010, Dougherty et al., 2008, Abruzzi et al., 2011, Japanese National Institute of Genetics, 2012.5.21) Opa (Prazak et al., 2007, Mahoney et al., 2006, Noyes et al., 2008, Bandyopadhyay et al., 2006)
Name Synonym	GLI-Kr zinc finger pair-rule protein (Benedyk, 1993.12.15) odd-paired (Aruga, 2004, Lee et al., 2007, Sen et al., 2008, Ishihara and Shibata, 2008) odd paired (Jones et al., 2006, Moorman et al., 2006, Moorman et al., 2006, Munoz-Descalzo et al., 2007, Zheng et al., 2011, Sen et al., 2010) Odd paired (Tucker and Chiquet-Ehrismann, 2006) Odd-paired (Veitia, 2006, Prazak et al., 2010)
Secondary FlyBase IDs
References ( 128 )
Generate a list of	All references relating to this gene ( 128 )
List References by type	Research paper  ( 82 ) Supplementary material  ( 4 ) Review  ( 12 ) Personal communication to FlyBase  ( 8 ) Abstract  ( 10 ) FlyBase analysis  ( 1 ) DNA/RNA sequence record  ( 1 ) Stock list  ( 2 ) Curated genome annotation  ( 3 ) Book  ( 1 ) Protein sequence record  ( 1 ) Website  ( 1 ) Letter  ( 1 )
Recent research papers ( 10 )
	Schaub and Frasch, 2013, Dev. Biol. 376(2): 245--259 Org-1 is required for the diversification of circular visceral muscle founder cells and normal midgut morphogenesis. [FBrf0221030] Shu and Li, 2013, Theor. Biol. Med. Model. 10(1): 11 A statistical thin-tail test of predicting regulatory regions in the Drosophila genome. [FBrf0221021] Gaertner et al., 2012, Cell Rep. 2(6): 1670--1683 Poised RNA Polymerase II Changes over Developmental Time and Prepares Genes for Future Expression. [FBrf0220312] Hazelett et al., 2012, G3 (Bethesda) 2(7): 789--802 Comparison of Parallel High-Throughput RNA Sequencing Between Knockout of TDP-43 and Its Overexpression Reveals Primarily Nonreciprocal and Nonoverlapping Gene Expression Changes in the Central Nervous System of Drosophila. [FBrf0219102] Shu and Li, 2012, Comput. Biol. Med. 42(9): 935--941 A statistical fat-tail test of predicting regulatory regions in the Drosophila genome. [FBrf0219304] Abruzzi et al., 2011, Genes Dev. 25(22): 2374--2386 Drosophila CLOCK target gene characterization: implications for circadian tissue-specific gene expression. [FBrf0216798] Harrison et al., 2011, PLoS Genet. 7(10): e1002266 Zelda Binding in the Early Drosophila melanogaster Embryo Marks Regions Subsequently Activated at the Maternal-to-Zygotic Transition. [FBrf0216528] Kaplan et al., 2011, PLoS Genet. 7(2): e1001290 Quantitative Models of the Mechanisms That Control Genome-Wide Patterns of Transcription Factor Binding during Early Drosophila Development. [FBrf0213025] Walrad et al., 2011, Mol. Biol. Cell 22(8): 1364--1374 Hairless is a cofactor for Runt-dependent transcriptional regulation. [FBrf0213441] Zheng et al., 2011, PLoS ONE 6(8): e22956 Drosophila Ten-m and Filamin Affect Motor Neuron Growth Cone Guidance. [FBrf0214744] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2011 Show reviews ...