FB2021_02, released April 13, 2021

Gene: Dmel\osp

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General Information
Symbol
Dmel\osp
Species
D. melanogaster
Name
outspread
Annotation Symbol
CG3479
Feature Type
protein_coding_gene
FlyBase ID
FBgn0003016
Gene Model Status
Current
Stock Availability
21 publicly available
Gene Summary
outspread (osp) encodes a protein that contributes to embryonic crystal cell formation and the proper morphogenesis of the adult wing. [Date last reviewed: 2019-03-14] (FlyBase Gene Snapshot)
All Summaries
Also Known As

BG:DS01486.7

Key Links
Genomic Location
Cytogenetic map
35B3-35B4
Sequence location
2L:14,599,196..14,689,340 [-]
Recombination map
2-50
RefSeq locus
NT_033779 REGION:14599196..14689340
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
GO Summary Ribbons
Gene Ontology (GO) Annotations (3 terms)
Molecular Function (1 term)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
enables actin filament binding
inferred from sequence or structural similarity with UniProtKB:Q9H2D6
(FlyBase Curators, 2008--)
inferred from biological aspect of ancestor with PANTHER:PTN000425526
(assigned by GO_Central )
(Gaudet et al., 2011)
Biological Process (1 term)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
involved_in actin filament organization
inferred from biological aspect of ancestor with PANTHER:PTN000425526
(assigned by GO_Central )
(Gaudet et al., 2011)
Cellular Component (1 term)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
located_in actin cytoskeleton
inferred from biological aspect of ancestor with PANTHER:PTN000425526
(assigned by GO_Central )
(Gaudet et al., 2011)
inferred from sequence or structural similarity with UniProtKB:Q9H2D6
(FlyBase Curators, 2008--)
Gene Group (FlyBase)
Protein Family (UniProt)
-
Protein Signatures (InterPro)
Summaries
Gene Snapshot
outspread (osp) encodes a protein that contributes to embryonic crystal cell formation and the proper morphogenesis of the adult wing. [Date last reviewed: 2019-03-14]
Phenotypic Description (Red Book; Lindsley and Zimm 1992)
*alw: arclike wing
Wings evenly bent downward at tips. Overlaps wild type. RK2.
osp: outspread (M. Ashburner)
Wings held out at 45 to body axis. Strong alleles, and homozygous deficiencies show, in addition, a "tenting" of the wings so that they resemble those of arc. Df(2L)osp homozygous viable and fertile, though viability reduced in crowded cultures.
Gene Model and Products
Number of Transcripts
4
Number of Unique Polypeptides
4

Please see the JBrowse view of Dmel\osp for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model

Alternative translation stop created by use of multiphasic reading frames within coding region.

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.52

Sequence Ontology: Class of Gene
nuclear_gene
protein_coding_gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
osp-RC
FBtr0114465
NM_001144354
5917
1386
osp-RD
FBtr0301494
NM_165089
6239
1557
osp-RE
FBtr0301495
NM_078843
5890
1377
osp-RF
FBtr0301496
NM_001169504
6846
1566
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
osp-PC
FBpp0112957
156.2
1386
6.63
NP_001137826
ACL83032
osp-PD
FBpp0290709
174.5
1557
6.58
NP_723879
AAF53402
osp-PE
FBpp0290710
155.2
1377
6.63
NP_523567
AAN10878
osp-PF
FBpp0290711
175.5
1566
6.58
NP_001162975
ACZ94261
Polypeptides with Identical Sequences

None of the polypeptides share 100% sequence identity.

Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Nucleotide / Polypeptide Records
 
UniProt
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\osp using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
Polypeptide Expression
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
day 5 of adulthood & male -- day 7 of adulthood & male
spermatozoon
(Wasbrough et al., 2010)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\osp in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyExpress - Embryonic expression images (BDGP data)
  • Stages(s) 11-12
  • Stages(s) 13-16
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 60 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 3 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of osp
Transgenic constructs containing regulatory region of osp
Aberrations (Deficiencies and Duplications) ( 215 )
Inferred from experimentation ( 215 )
Gene disrupted in
Df(2L)64j
(Woodruff and Ashburner, 1979, Woodruff and Ashburner, 1979)
Df(2L)A47
(McNabb et al., 1996, Roote et al., 1996, Fossett et al., 1994, Gubb et al., 1990, Ashburner et al., 1982)
Df(2L)A48
(Ashraf et al., 1999, McNabb et al., 1996, Roote et al., 1996, Fossett et al., 1994, Gubb et al., 1990, Grau et al., 1984, Ashburner et al., 1982, Ashburner et al., 1982)
Df(2L)A63
(McNabb et al., 1996, Roote, 1996.8, Roote et al., 1996, Fossett et al., 1994, Ashburner et al., 1982, Ashburner et al., 1982)
Df(2L)A72
(McNabb et al., 1996, Roote et al., 1996, Fossett et al., 1994, Ashburner et al., 1982, Ashburner et al., 1982)
Df(2L)A178
(Roote et al., 1996, Fossett et al., 1994, Ashburner et al., 1982, Ashburner et al., 1982)
Df(2L)A215
(Fossett et al., 1994, Ashburner et al., 1982)
Df(2L)A217
(McNabb et al., 1996, Roote, 1996.8, Fossett et al., 1994, Ashburner et al., 1982)
Df(2L)A220
(McNabb et al., 1996, Roote et al., 1996, Fossett et al., 1994, Ashburner et al., 1982)
Df(2L)A245
(McNabb et al., 1996, Roote, 1996.8, Roote et al., 1996, Fossett et al., 1994, Ashburner et al., 1982)
Df(2L)A246
(Fossett et al., 1994, Ashburner et al., 1982)
Df(2L)A260
(McNabb et al., 1996, Roote, 1996.8, Ashburner et al., 1982)
Df(2L)A263
(Ashburner et al., 1982)
Df(2L)A264
(Fossett et al., 1994, Ashburner et al., 1982)
Df(2L)A266
(McNabb et al., 1996, Roote, 1996.8, Fossett et al., 1994, Ashburner et al., 1982, Ashburner et al., 1982)
Df(2L)A267
(Roote et al., 1996, Fossett et al., 1994, Ashburner et al., 1982, Ashburner et al., 1982)
Df(2L)A337
(Fossett et al., 1994)
Df(2L)A376
(Fossett et al., 1994, Ashburner et al., 1982)
Df(2L)A377
(Ashburner et al., 1982)
Df(2L)A379
(McNabb et al., 1996, Fossett et al., 1994, Ashburner et al., 1982, Ashburner et al., 1982)
Df(2L)A400
(Roote et al., 1996, Fossett et al., 1994, Ashburner et al., 1982, Ashburner et al., 1982)
Df(2L)A445
(McNabb et al., 1996, Roote, 1996.8, Roote et al., 1996, Fossett et al., 1994, Ashburner et al., 1982)
Df(2L)Adh-nBR41
(Fossett et al., 1990)
Df(2L)Adh-nBR55
(Fossett et al., 1990)
Df(2L)Adh-nBR100
(Fossett et al., 1994)
Df(2L)Adh-nBR101
(Fossett et al., 1994)
Df(2L)Adh-nBR102
(Roote et al., 1996, Fossett et al., 1994)
Df(2L)Adh-nBR103
(Fossett et al., 1994)
Df(2L)Adh-nBR105
(Roote, 1996.1.11, Roote, 1996.8, Roote et al., 1996, Fossett et al., 1994)
Df(2L)Adh-nBR106
(Fossett et al., 1994)
Df(2L)Adh-nBR107
(Roote, 1996.1.11, Roote, 1996.8, Roote et al., 1996, Fossett et al., 1994)
Df(2L)Adh-nBR111
(Fossett et al., 1990)
Df(2L)Adh-nBR117
(Fossett et al., 1994)
Df(2L)Adh-nBR118
(Fossett et al., 1994)
Df(2L)Adh-nBR119
(Fossett et al., 1994)
Df(2L)Adh-nBR120
(Fossett et al., 1994)
Df(2L)Adh-nBR121
(Roote, 1996.1.11, Roote, 1996.8, Roote et al., 1996, Fossett et al., 1994)
Df(2L)Adh-nBR122
(Roote, 1996.1.11, Roote, 1996.8, Roote et al., 1996, Fossett et al., 1994)
Df(2L)Adh-nBR125
(Fossett et al., 1994)
Df(2L)Adh-nBR126
(Fossett et al., 1994)
Df(2L)Adh-nBR127
(Roote, 1996.1.11, Roote, 1996.8, Roote et al., 1996, Fossett et al., 1994)
Df(2L)Adh-nBR128
(Roote, 1996.1.11, Roote, 1996.8, Roote et al., 1996, Fossett et al., 1994)
Df(2L)Adh-nBR129
(Fossett et al., 1994)
Df(2L)Adh-nBR130
(Fossett et al., 1994)
Df(2L)Adh-nBR131
(Fossett et al., 1994)
Df(2L)ARR1
(Roote et al., 1996)
Df(2L)b84a1
(McNabb et al., 1996, Roote, 1996.8)
Df(2L)b84h50
(Spradling et al., 1999, BDGP Project Members, 1994-1999)
Df(2L)b88c25
(Roote, 2002.1.15, Roote, 2000.6.5, Roote, 2000.7.3)
Df(2L)b89e68
(Roote, 2002.1.15, Roote, 2000.6.5, Roote, 2000.7.3)
Df(2L)b89e88b
(Roote, 2000.6.5)
Df(2L)do1
(Ashburner et al., 1981)
Df(2L)ED3
(Ryder and Roote, 2004.11.10, Roote, 2002.2.6)
Df(2L)el77
(McNabb et al., 1996, Woodruff and Ashburner, 1979, Woodruff and Ashburner, 1979)
Df(2L)el80f1
(Ashburner et al., 1983)
Df(2L)el81i1
(Roote, 2002.1.15)
Df(2L)Exel8033
(Ryder, 2004.4.26)
Df(2L)fn1
(Grau et al., 1984, Ashburner et al., 1982, Ashburner et al., 1982, Woodruff and Ashburner, 1979, Woodruff and Ashburner, 1979)
Df(2L)fn2
(McNabb et al., 1996, Roote, 1996.8, Roote et al., 1996, Grau et al., 1984, Ashburner et al., 1982, Ashburner et al., 1982, Woodruff and Ashburner, 1979, Woodruff and Ashburner, 1979)
Df(2L)fn3
(Ashburner et al., 1982, Woodruff and Ashburner, 1979, Woodruff and Ashburner, 1979)
Df(2L)fn5
(Ashburner et al., 1982)
Df(2L)fn7
(McNabb et al., 1996, Roote, 1996.8, Ashburner et al., 1982, Woodruff and Ashburner, 1979, Woodruff and Ashburner, 1979)
Df(2L)fn12
(Ashburner et al., 1982, Woodruff and Ashburner, 1979)
Df(2L)fn15
(Ashburner et al., 1982)
Df(2L)fn26
(Ashburner et al., 1982)
Df(2L)fn27
(Ashburner et al., 1982, Ashburner et al., 1982)
Df(2L)fn30
(Ashburner et al., 1982)
Df(2L)fn31
(Ashburner et al., 1982)
Df(2L)fn36
(McNabb et al., 1996, Roote, 1996.8, Ashburner et al., 1982)
Df(2L)fn52
(McNabb et al., 1996, Roote, 1996.8, Roote et al., 1996)
Df(2L)GT5
(Gubb et al., 1990)
Df(2L)k08808-mr1
(Roote, 2002.2.18)
Df(2L)n78l3
(Ashburner et al., 1982)
Df(2L)nNxF1
(Chia et al., 1985)
Df(2L)nNxF2
(Chia et al., 1985)
Df(2L)noc10
(McNabb et al., 1996, Roote, 1996.8)
Df(2L)noc13
(McNabb et al., 1996, Roote, 1996.8)
Df(2L)noc20
(McNabb et al., 1996)
Df(2L)osp18
(Ashraf et al., 1999, McNabb et al., 1996, Roote et al., 1996)
Df(2L)osp29
(Ashraf et al., 1999, McNabb et al., 1996, Roote, 1996.8, Roote et al., 1996)
Df(2L)osp144
(McNabb et al., 1996, Roote, 1996.8, Roote et al., 1996, Ashburner et al., 1982)
Df(2L)osp201
(McNabb et al., 1996)
Df(2L)osp-204
Df(2L)PA4
(Roote, 2002.1.15, Ashburner et al., 1983)
Df(2L)Sco-2
Df(2L)Sco7
(Ashburner et al., 1983)
Df(2L)Scorv4
(Ashburner et al., 1990, Ashburner et al., 1983, Woodruff and Ashburner, 1979, Woodruff and Ashburner, 1979)
Df(2L)Scorv10
(Grau et al., 1984, Ashburner et al., 1983, Ashburner et al., 1980, Woodruff and Ashburner, 1979)
Df(2L)Scorv14
(Ashburner et al., 1983, Ashburner et al., 1980, Woodruff and Ashburner, 1979)
Df(2L)Scorv18
(Ashburner et al., 1983, Ashburner et al., 1980)
Df(2L)Scorv23
(Grau et al., 1984, Ashburner et al., 1983)
Df(2L)TE35B-1
(Gubb et al., 1985)
Df(2L)TE35B-2
(Gubb et al., 1985)
Df(2L)TE35B-3
(Gubb et al., 1985)
Df(2L)TE35B-5
(Gubb et al., 1985)
Df(2L)TE35B-6
(Gubb et al., 1985)
Df(2L)TE35B-7
(Roote et al., 1996, Gubb et al., 1985)
Df(2L)TE35B-8
(McNabb et al., 1996, Roote et al., 1996, Gubb et al., 1985)
Df(2L)TE35B-9
(McNabb et al., 1996, Roote, 1996.8, Gubb et al., 1985)
Df(2L)TE35B-11
(McNabb et al., 1996, Roote, 1996.8, Roote et al., 1996, Gubb et al., 1985)
Df(2L)TE35B-15
(McNabb et al., 1996, Roote, 1996.8, Gubb et al., 1985)
Df(2L)TE35B-48
(Gubb et al., 1997, McNabb et al., 1996, Roote, 1996.8, Gubb et al., 1986)
Df(2L)TE35B-54L
(Roote et al., 1996)
Df(2L)TE35B-54
(Gubb et al., 1997, McNabb et al., 1996, Gubb et al., 1986)
Df(2L)TE35BC-6
(Gubb et al., 1984)
Df(2L)TE35BC-7
(Gubb et al., 1984)
Df(2L)TE35BC-8
(Gubb et al., 1984)
Df(2L)TE35BC-23
(Gubb et al., 1984)
Df(2L)TE35BC-29
(Gubb et al., 1984)
Df(2L)TE35BC-31
(Gubb et al., 1984)
Df(2L)W
(McNabb et al., 1996, Roote, 1996.8, Ashburner et al., 1982, Woodruff and Ashburner, 1979, Woodruff and Ashburner, 1979)
In(2L)75cLC158.1R
(Woodruff and Ashburner, 1979, Woodruff and Ashburner, 1979)
In(2L)75c
(Grau et al., 1984, Woodruff and Ashburner, 1979, Woodruff and Ashburner, 1979)
In(2L)b88e16
(Roote, 2000.6.5)
In(2L)C158LScorv11R
(Ashburner et al., 1983)
In(2L)C158LScorv17R
(Ashburner et al., 1983)
In(2L)dppH86
(Roote et al., 1996)
In(2L)osp22
(McNabb et al., 1996, Roote et al., 1996)
In(2L)osp59
(McNabb et al., 1996, Roote et al., 1996)
In(2L)TE35B-13
(Gubb et al., 1985)
In(2LR)el6LA379R
(Roote, 2002.1.15, Roote, 1996.1.11, Roote, 1996.8, Roote et al., 1996)
In(2LR)noc4LScorv9R
(Ashburner and Harrington, 1984)
In(2LR)Scorv1LTE35B-15R
(Roote et al., 1996)
In(2LR)TE35B-4LScorv1R
(Roote, 2002.1.15)
In(2LR)TE35B-6LScorv9R
(Ashburner and Harrington, 1984)
In(2LR)TE35B-14LScorv1R
(Roote, 2002.1.15)
T(2;3)88g68
(Roote, 2000.6.5)
T(2;3)GT7
(Gubb et al., 1990)
T(2;3)H47
(McNabb et al., 1996, Roote et al., 1996)
T(2;3)Mpe
(McNabb et al., 1996)
T(2;3)osp90
(McNabb et al., 1996, Roote et al., 1996)
T(2;3)Scorv7
(Ashburner and Harrington, 1984, Grau et al., 1984, Ashburner et al., 1983, Ashburner et al., 1980, Woodruff and Ashburner, 1979, Woodruff and Ashburner, 1979)
T(2;3)TE35B-2a
(Chia et al., 1985)
T(2;3)TE35B-3DG16P
(Chia et al., 1985)
T(Y;2)A80DR15P
(Ashburner et al., 1982, Woodruff and Ashburner, 1979, Woodruff and Ashburner, 1979)
T(Y;2)GT1
(Gubb et al., 1990)
Tp(1;2)TE35B-ospA5
(Moschetti et al., 2004)
Tp(2;2)A446
(Roote et al., 1996, Fossett et al., 1994, Ashburner et al., 1982, Ashburner et al., 1982)
Tp(2;3)osp3
(McNabb et al., 1996)
Tp(2;3)pb3
(McNabb et al., 1996, Roote et al., 1996, Ashburner et al., 1981)
Tp(3;2)osp204
(Roote et al., 1996)
Ts(2Lt;3Lt)GT7+Ts(2Rt;3Rt)Scorv13
(Roote, 2002.1.15, Roote et al., 1996)
Ts(2Lt;3Lt)Mpe+Ts(2Rt;3Rt)G16
(Chia et al., 1985)
Ts(2Lt;3Lt)TE35B-4+Ts(2Rt;3Rt)Scorv13
(Chia et al., 1985, Ashburner and Harrington, 1984)
Ts(2Lt;3Lt)TE35B-28+Ts(2Rt;3Rt)osp90
(Roote et al., 1996, Roote, 1995.3.27)
Ts(2Lt;3Lt)TE35BC-3+Ts(2Rt;3Rt)Scorv13
(Ashburner et al., 1983)
Ts(2Lt;4Lt)TE35B-50+Ts(2Rt;4Rt)DTD22
(Roote, 2002.1.15)
Ts(2Lt;4Lt)TE35B-101+Ts(2Rt;4Rt)DTD22
(Roote, 2002.1.15)
Ts(Y;2Lt)el4+Ts(YSt;2Rt)R15
(Roote et al., 1996, Ashburner et al., 1982)
Ts(Y;2Lt)GT1+Ts(YSt;2Rt)R15
(Roote et al., 1996)
Ts(YLt;2Lt)G74+Ts(YSt;2Rt)B210
(Woodruff and Ashburner, 1979)
Ts(YSt;2Lt)G74+Ts(YSt;2Rt)J165
(Woodruff and Ashburner, 1979)
Ts(YSt;2Lt)G74+Ts(YSt;2Rt)P58
(Woodruff and Ashburner, 1979)
Ts(YSt;2Lt)G74+Ts(YSt;2Rt)R15
(Woodruff and Ashburner, 1979)
Gene not disrupted in
Df(2L)A48
(Spradling et al., 1999, BDGP Project Members, 1994-1999)
Df(2L)b75
(Gubb et al., 1990, Woodruff and Ashburner, 1979, Woodruff and Ashburner, 1979)
Df(2L)b80e3
(Roote et al., 1996, Ashburner et al., 1982)
Df(2L)b81a1
(Roote et al., 1996, Ashburner et al., 1982)
Df(2L)b83d29a
(Roote et al., 1996)
Df(2L)b84a2
(Roote et al., 1996)
Df(2L)b84a4
(Roote, 2000.7.3, McNabb et al., 1996, Roote et al., 1996)
Df(2L)b84a8
(Roote, 2000.7.3, McNabb et al., 1996)
Df(2L)b88h49
(Roote et al., 1996)
Df(2L)el14
(Roote et al., 1996)
Df(2L)GT4
(McNabb et al., 1996, Gubb et al., 1990)
Df(2L)osp29
(Chia et al., 1985, Grau et al., 1984, Ashburner et al., 1982)
Df(2L)Sco-1
(Ashburner, 1982)
Df(2L)Scorv16
(Grau et al., 1984, Ashburner et al., 1983)
Df(2L)Scorv19
(Grau et al., 1984, Ashburner et al., 1983)
Df(2L)Scorv25
(Grau et al., 1984, Ashburner et al., 1983)
Df(2L)SS1
(Grau et al., 1984)
Df(2L)TE35B-4
(Gubb et al., 1985)
Df(2L)TE35B-10
(Gubb et al., 1985)
Df(2L)TE35B-12
(Roote, 1996.8, Roote et al., 1996, Gubb et al., 1985)
Df(2L)TE35B-203
(Roote, 2002.1.15)
Df(2L)TE35B-300
(Roote et al., 1996)
Df(2L)TE35BC-1
(Gubb et al., 1984)
Df(2L)TE35BC-3
(Grau et al., 1984, Gubb et al., 1984, Ashburner et al., 1982)
Df(2L)TE35BC-4
(McNabb et al., 1996, Roote et al., 1996, Gubb et al., 1984, Ashburner et al., 1982)
Df(2L)TE35BC-24
(Gubb et al., 1984)
Df(2L)TE35BC-28
(McNabb et al., 1996, Gubb et al., 1984)
Df(2L)TE35BC-34
(Roote, 1996.8, Gubb et al., 1984)
Df(2L)TE35BC-35
(McNabb et al., 1996, Gubb et al., 1984)
Dp(2;2)Cam12
(Roote et al., 1996)
In(2L)C158LScorv11R
(Ashburner and Harrington, 1984, Ashburner et al., 1981)
In(2L)C158LScorv17R
(Ashburner and Harrington, 1984)
In(2L)C158
(McNabb et al., 1996, Roote et al., 1996)
In(2L)Scorv11
(Roote et al., 1996)
In(2L)Scorv17
(Roote et al., 1996)
In(2LR)b81a2LDTD43R
(Roote, 2002.1.15, Roote, 2000.7.3)
In(2LR)D20Lnoc4R
(Roote et al., 1996)
In(2LR)noc4LTE35B-50R
(Roote, 2002.1.15)
T(2;3)GT7
(Roote et al., 1996)
T(2;3)TE35BC-3
(McNabb et al., 1996, Roote et al., 1996)
T(Y;2)GT1
(Roote et al., 1996)
T(Y;2)J165DP58P
(Woodruff and Ashburner, 1979, Woodruff and Ashburner, 1979)
T(Y;2)R15DJ165P
(Woodruff and Ashburner, 1979, Woodruff and Ashburner, 1979)
Ts(2Lt;3Lt)dpps19+Ts(2Rt;3Rt)el24
(Roote et al., 1996)
Ts(2Lt;3Lt)H118+Ts(2Rt;3Rt)TE35B-8
(Roote, 2002.1.15)
Ts(2Lt;3Lt)H147+Ts(2Rt;3Rt)TE35B-8
(Roote, 2002.1.15)
Ts(2Lt;3Lt)TE35B-4+Ts(2Rt;3Rt)Scorv13
(Roote, 2002.1.15)
Ts(2Lt;3Lt)TE35BC-3+Ts(2Rt;3Rt)Scorv13
(McNabb et al., 1996, Ashburner and Harrington, 1984)
Ts(2Lt;3Rt)GT10+Ts(2Rt;3Lt)TE35B-209
(Roote et al., 1996)
Ts(2Lt;4Lt)GT6+Ts(2Rt;4Rt)TE35B-101
(Roote, 2002.1.15)
Ts(Y;2Lt)el4+Ts(YSt;2Rt)A80
(Roote et al., 1996)
Ts(Y;2Lt)GT2+Ts(YSt;2Rt)A80
(Roote et al., 1996)
Ts(YSt;2Lt)G74+Ts(YSt;2Rt)A80
(Woodruff and Ashburner, 1979)
Gene not duplicated in
In(2L)C163.41LC158R
(Roote et al., 1996, Ashburner et al., 1982)
In(2LR)TE35B-226LDTD128R
(Roote et al., 1996)
Ts(2Lt;4Lt)TE35B-101+Ts(2Rt;4Rt)GT6
(Roote et al., 1996)
Ts(Y;2Lt)TE35B-18+Ts(YSt;2Rt)A80
(Roote et al., 1996)
Ts(YLt;2Lt)A80+Ts(Y;2Rt)el4
(Roote et al., 1996)
Ts(YLt;2Lt)A80+Ts(YLt;2Rt)G74
(Roote et al., 1996)
Gene duplicated in
Dp(2;1)Scorv23
(Grau et al., 1984, Ashburner et al., 1983)
Dp(2;2)TE35B-54L
(Roote et al., 1996)
In(2L)C163.41LTE35B-210R
(Roote et al., 1996)
In(2LR)Scorv1LTE35B-4R
(Roote et al., 1996)
In(2LR)Scorv1LTE35B-14R
(Roote et al., 1996)
Ts(2Lt;3Lt)G16+Ts(2Rt;3Rt)TE35B-3
(Roote et al., 1996)
Ts(2Lt;4Lt)DTD22+Ts(2Rt;4Rt)TE35B-50
(Roote et al., 1996)
Ts(YLt;2Lt)R15+Ts(Y;2Rt)el4
(Roote et al., 1996)
Ts(YLt;2Lt)R15+Ts(Y;2Rt)TE35B-18
(Roote et al., 1996)
Ts(YLt;2Lt)R15+Ts(YSt;2Rt)A80
(Roote et al., 1996)
Inferred from location ( 0 )
Phenotypes
Orthologs
Downloads
Download All DIOPT Orthologs
Download All OrthoDB Orthologs
Human Orthologs (via DIOPT v8.0)
Homo sapiens (Human) (2)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Hsap\MPRIP
9 of 15
Yes
Yes
Hsap\TRIOBP
6 of 15
No
Yes
Model Organism Orthologs (via DIOPT v8.0)
Mus musculus (laboratory mouse) (2)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Mmus\Mprip
8 of 15
Yes
Yes
Mmus\Triobp
5 of 15
No
Yes
Rattus norvegicus (Norway rat) (2)
Rnor\Mprip
6 of 13
Yes
Yes
Rnor\Triobp
3 of 13
No
Yes
Xenopus tropicalis (Western clawed frog) (2)
Xtro\triobp
7 of 12
Yes
Yes
Xtro\mprip
6 of 12
No
Yes
Danio rerio (Zebrafish) (4)
Drer\mprip
8 of 15
Yes
Yes
Drer\si:ch73-103b11.2
8 of 15
Yes
Yes
Drer\triobpa
5 of 15
No
Yes
Drer\triobpb
5 of 15
No
Yes
Caenorhabditis elegans (Nematode, roundworm) (1)
Cele\F10G8.8
9 of 15
Yes
Yes
Arabidopsis thaliana (thale-cress) (0)
No records found.
Saccharomyces cerevisiae (Brewer's yeast) (0)
No records found.
Schizosaccharomyces pombe (Fission yeast) (0)
No records found.
Ortholog(s) in Drosophila Species (via OrthoDB v9.1) ( EOG091900UB )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila suzukii
Spotted wing Drosophila
Dsuz\DS10_00000161
Drosophila simulans
Dsim\GD21995
Drosophila sechellia
Dsec\GM14739
Drosophila erecta
Dere\GG24247
Drosophila yakuba
Dyak\GE24875
Drosophila ananassae
Dana\GF15007
Drosophila pseudoobscura pseudoobscura
Dpse\GA17472
Drosophila persimilis
Dper\GL25755
Drosophila willistoni
Dwil\GK18083
Drosophila virilis
Dvir\GJ18021
Drosophila mojavensis
Dmoj\GI10322
Drosophila grimshawi
Dgri\GH13845
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG091500I1 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Mdoa\17007679
Glossina morsitans
Tsetse fly
Gmor\GMOY006497
Lucilia cuprina
Australian sheep blowfly
Lcup\FF38_07540
Aedes aegypti
Yellow fever mosquito
Aaeg\AAEL008670
Anopheles darlingi
American malaria mosquito
Adar\ADAC007413
Anopheles gambiae
Malaria mosquito
Agam\AGAP009847
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ009066
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W0I9U )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Bombyx mori
Silkmoth
Bmor\BGIBMGA006651
Danaus plexippus
Monarch butterfly
Dple\DPOGS209591-PA
Heliconius melpomene
Postman butterfly
Hmel\HMEL017014
Apis florea
Little honeybee
Aflo\2178233508
Apis mellifera
Western honey bee
Amel\GB55755
Apis mellifera
Western honey bee
Amel\GB48192
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP13899
Bombus terrestris
Buff-tailed bumblebee
Bter\15215355
Linepithema humile
Argentine ant
Lhum\LH19575
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:0003b5
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG032743
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG025398
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_07260
Tribolium castaneum
Red flour beetle
Tcas\TC033274
Tribolium castaneum
Red flour beetle
Tcas\TC008527
Pediculus humanus
Human body louse
Phum\PHUM051580
Rhodnius prolixus
Kissing bug
Rpro\RPRC001201
Rhodnius prolixus
Kissing bug
Rpro\RPRC001200
Cimex lectularius
Bed bug
Clec\CLEC001852
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI008555
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_12823
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X0IDC )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strigamia maritima
European centipede
Smar\SMAR002331
Ixodes scapularis
Black-legged tick
Isca\ISCW007121
Stegodyphus mimosarum
African social velvet spider
Smim\KFM61748.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM82809.1
Tetranychus urticae
Two-spotted spider mite
Turt\tetur25g01480
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_318416
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_27344
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( None identified )
No non-Arthropod Metazoa orthologies identified
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v8.0)
Drosophila melanogaster (Fruit fly) (0)
No records found.
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Model Summary Ribbon
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 1 )
    Modifiers Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Interaction
    References
    Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    MPRIP; myosin phosphatase Rho interacting protein
    9 of 15
    612935
        TRIOBP; TRIO and F-actin binding protein
        6 of 15
        609761
        Functional Complementation Data
        Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
        Interactions
        Summary of Physical Interactions
        esyN Network Diagram
        Interactions Browser
        Summary of Genetic Interactions
        esyN Network Diagram
        esyN Network Key:
        Suppression
        Enhancement
        View in Interactions Browser
        Please look at the allele data for full details of the genetic interactions
        Starting gene(s)
        Interaction type
        Interacting gene(s)
        Reference
        osp
        enhanceable
        Dcr-2
        (Dietzl et al., 2007)
        Starting gene(s)
        Interaction type
        Interacting gene(s)
        Reference
        External Data
        Linkouts
        BioGRID - A database of protein and genetic interactions.
        DroID - A comprehensive database of gene and protein interactions.
        InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
        Pathways
        Signaling Pathways (FlyBase)
        Metabolic Pathways
        External Data
        Linkouts
        Genomic Location and Detailed Mapping Data
        Chromosome (arm)
        2L
        Recombination map
        2-50
        Cytogenetic map
        35B3-35B4
        Sequence location
        2L:14,599,196..14,689,340 [-]
        FlyBase Computed Cytological Location
        Cytogenetic map
        Evidence for location
        35B3-35B4
        Limits computationally determined from genome sequence between P{EP}elBEP2039&P{PZ}osprJ571 and P{lacW}Su(H)k07904
        Experimentally Determined Cytological Location
        Cytogenetic map
        Notes
        References
        35B1-35B4
        (determined by in situ hybridisation) 35B3--5 (determined by in situ hybridisation)
        (Ashburner et al., 1999)
        35B1-35B4
        (determined by in situ hybridisation)
        (Spradling et al., 1999)
        35B1-35B4
        (BDGP Project Members, 1994-1999)
        Experimentally Determined Recombination Data
        Location

        2-50

        (FlyBase, 2016)

        2-47.1

        (Comeron et al., 2012)

        2-50.1

        Left of (cM)
        (Lindsley and Zimm, 1992)
        (Woodruff and Ashburner, 1979)
        (Sturtevant, 1948)
        Right of (cM)
        (Woodruff and Ashburner, 1979)
        (Sturtevant, 1948)
        Notes

        Maps very near b.

        (Sturtevant, 1948)
        Stocks and Reagents
        Stocks (21)
        Genomic Clones (45)
        cDNA Clones (411)
         

        Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

        cDNA clones, fully sequenced
        BDGP DGC clones
        Other clones
        Drosophila Genomics Resource Center cDNA clones

        For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

        cDNA Clones, End Sequenced (ESTs)
        BDGP DGC clones
        Other clones
        RNAi and Array Information
        Linkouts
        DRSC - Results frm RNAi screens
        GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
        Antibody Information
        Laboratory Generated Antibodies
         
        Commercially Available Antibodies
         
        Other Information
        Relationship to Other Genes
        Source for database identify of

        Source for identity of: osp CG3479

        (Kodira, 1999.11)
        Source for database merge of

        Source for merge of: osp anon-WO02059370.75

        (FlyBase, 1996-)
        Additional comments

        " BG:DS09219.1 " is located within osp and is predicted to be transcribed in the same direction as osp. It may therefore be part of the osp gene, if osp has an alternative transcript that has not yet been identified as a cDNA.

        (Ashburner et al., 1999)

        Source for merge of osp anon-WO02059370.75 was sequence comparison ( date:051113 ).

        (FlyBase, 1996-)

        Since "osp" is very near the 2L breakpoint of T(2;3)Mpe, the "Mpe1" phenotype may be due to a dominant "osp" allele.

        (Ashburner et al., 1981)

        Allelism of osp and alw assumed on basis of phenotype and map position (Ashburner).

        Other Comments

        osp is not a vital gene.

        (Ashburner et al., 1999)

        Adh and Adhr are nested within osp and osp has a transcription unit greater than 74kb.

        (McNabb et al., 1996)
        Origin and Etymology
        Discoverer
        Etymology
        Identification
        External Crossreferences and Linkouts ( 68 )
        Sequence Crossreferences
        NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
        GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
        GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
        RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
        UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
        Other crossreferences
        BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
        Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
        Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
        Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
        Flygut - An atlas of the Drosophila adult midgut
        GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
        InterPro - A database of protein families, domains and functional sites
        KEGG Genes - Molecular building blocks of life in the genomic space.
        modMine - A data warehouse for the modENCODE project
        Linkouts
        BioGRID - A database of protein and genetic interactions.
        DroID - A comprehensive database of gene and protein interactions.
        DRSC - Results frm RNAi screens
        FLIGHT - Cell culture data for RNAi and other high-throughput technologies
        FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
        FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
        FlyMine - An integrated database for Drosophila genomics
        InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
        Synonyms and Secondary IDs (12)
        Datasets (0)
        Study focus (0)
        Experimental Role
        Project
        Project Type
        Title
        References (104)