FB2025_02 , released April 17, 2025
Gene: Dmel\osp
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General Information
Symbol
Dmel\osp
Species
D. melanogaster
Name
outspread
Annotation Symbol
CG3479
Feature Type
protein_coding_gene
FlyBase ID
FBgn0003016
Gene Model Status
Current
Stock Availability
26 publicly available
Gene Summary
outspread (osp) encodes a protein that contributes to embryonic crystal cell formation and the proper morphogenesis of the adult wing. [Date last reviewed: 2019-03-14] (FlyBase Gene Snapshot)
All Summaries
Also Known As

BG:DS01486.7

Key Links
Genomic Location
Cytogenetic map
35B3-35B4
Sequence location
Recombination map
2-50
RefSeq locus
NT_033779 REGION:14599196..14689340
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
Gene Ontology (GO) Annotations (2 terms)
Molecular Function (1 term)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
enables actin filament binding
inferred from biological aspect of ancestor with PANTHER:PTN000425526
(GO Reference Genome Project, 2011-)
inferred from sequence or structural similarity with UniProtKB:Q9H2D6
(Gene Ontology Curators, 2002-)
Biological Process (0 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (0 terms)
Cellular Component (1 term)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
is_active_in actin cytoskeleton
inferred from biological aspect of ancestor with PANTHER:PTN000425526
(GO Reference Genome Project, 2011-)
located_in actin cytoskeleton
inferred from sequence or structural similarity with UniProtKB:Q9H2D6
(Gene Ontology Curators, 2002-)
Gene Group (FlyBase)
Protein Family (UniProt)
-
Protein Signatures (InterPro)
Summaries
Gene Snapshot
outspread (osp) encodes a protein that contributes to embryonic crystal cell formation and the proper morphogenesis of the adult wing. [Date last reviewed: 2019-03-14]
Phenotypic Description (Red Book; Lindsley and Zimm 1992)
*alw: arclike wing
Wings evenly bent downward at tips. Overlaps wild type. RK2.
osp: outspread (M. Ashburner)
Wings held out at 45 to body axis. Strong alleles, and homozygous deficiencies show, in addition, a "tenting" of the wings so that they resemble those of arc. Df(2L)osp homozygous viable and fertile, though viability reduced in crowded cultures.
Gene Model and Products
Number of Transcripts
4
Number of Unique Polypeptides
4

Please see the JBrowse view of Dmel\osp for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Structure
Protein 3D structure   (Predicted by AlphaFold)   (AlphaFold entry Q27421)

If you don't see a structure in the viewer, refresh your browser.
Model Confidence:
  • Very high (pLDDT > 90)
  • Confident (90 > pLDDT > 70)
  • Low (70 > pLDDT > 50)
  • Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures
Crossreferences
Comments on Gene Model

Alternative translation stop created by use of multiphasic reading frames within coding region.

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.52

Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
osp-RC
FBtr0114465
NM_001144354
5917
1386
osp-RD
FBtr0301494
NM_165089
6239
1557
osp-RE
FBtr0301495
NM_078843
5890
1377
osp-RF
FBtr0301496
NM_001169504
6846
1566
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
UniProt
RefSeq ID
GenBank
osp-PC
FBpp0112957
156.2
1386
6.63
NP_001137826
ACL83032
osp-PD
FBpp0290709
174.5
1557
6.58
NP_723879
AAF53402
osp-PE
FBpp0290710
155.2
1377
6.63
NP_523567
AAN10878
osp-PF
FBpp0290711
175.5
1566
6.58
Q27421
NP_001162975
ACZ94261
Polypeptides with Identical Sequences

None of the polypeptides share 100% sequence identity.

Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Nucleotide / Polypeptide Records
 
UniProt
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\osp using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-1.27

Transcript Expression
Polypeptide Expression
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
day 5 of adulthood & male -- day 7 of adulthood & male
spermatozoon
(Wasbrough et al., 2010)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\osp in JBrowse
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyExpress - Embryonic expression images (BDGP data)
  • Stages(s) 11-12
  • Stages(s) 13-16
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 62 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 4 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of osp
Transgenic constructs containing regulatory region of osp
Aberrations (Deficiencies and Duplications) ( 215 )
Inferred from experimentation ( 215 )
Gene disrupted in
Df(2L)64j
(Woodruff and Ashburner, 1979, Woodruff and Ashburner, 1979)
Df(2L)A47
(McNabb et al., 1996, Roote et al., 1996, Fossett et al., 1994, Gubb et al., 1990, Ashburner et al., 1982)
Df(2L)A48
(Ashraf et al., 1999, McNabb et al., 1996, Roote et al., 1996, Fossett et al., 1994, Gubb et al., 1990, Grau et al., 1984, Ashburner et al., 1982, Ashburner et al., 1982)
Df(2L)A63
(McNabb et al., 1996, Roote, 1996.8, Roote et al., 1996, Fossett et al., 1994, Ashburner et al., 1982, Ashburner et al., 1982)
Df(2L)A72
(McNabb et al., 1996, Roote et al., 1996, Fossett et al., 1994, Ashburner et al., 1982, Ashburner et al., 1982)
Df(2L)A178
(Roote et al., 1996, Fossett et al., 1994, Ashburner et al., 1982, Ashburner et al., 1982)
Df(2L)A215
(Fossett et al., 1994, Ashburner et al., 1982)
Df(2L)A217
(McNabb et al., 1996, Roote, 1996.8, Fossett et al., 1994, Ashburner et al., 1982)
Df(2L)A220
(McNabb et al., 1996, Roote et al., 1996, Fossett et al., 1994, Ashburner et al., 1982)
Df(2L)A245
(McNabb et al., 1996, Roote, 1996.8, Roote et al., 1996, Fossett et al., 1994, Ashburner et al., 1982)
Df(2L)A246
(Fossett et al., 1994, Ashburner et al., 1982)
Df(2L)A260
(McNabb et al., 1996, Roote, 1996.8, Ashburner et al., 1982)
Df(2L)A263
(Ashburner et al., 1982)
Df(2L)A264
(Fossett et al., 1994, Ashburner et al., 1982)
Df(2L)A266
(McNabb et al., 1996, Roote, 1996.8, Fossett et al., 1994, Ashburner et al., 1982, Ashburner et al., 1982)
Df(2L)A267
(Roote et al., 1996, Fossett et al., 1994, Ashburner et al., 1982, Ashburner et al., 1982)
Df(2L)A337
(Fossett et al., 1994)
Df(2L)A376
(Fossett et al., 1994, Ashburner et al., 1982)
Df(2L)A377
(Ashburner et al., 1982)
Df(2L)A379
(McNabb et al., 1996, Fossett et al., 1994, Ashburner et al., 1982, Ashburner et al., 1982)
Df(2L)A400
(Roote et al., 1996, Fossett et al., 1994, Ashburner et al., 1982, Ashburner et al., 1982)
Df(2L)A445
(McNabb et al., 1996, Roote, 1996.8, Roote et al., 1996, Fossett et al., 1994, Ashburner et al., 1982)
Df(2L)Adh-nBR41
(Fossett et al., 1990)
Df(2L)Adh-nBR55
(Fossett et al., 1990)
Df(2L)Adh-nBR100
(Fossett et al., 1994)
Df(2L)Adh-nBR101
(Fossett et al., 1994)
Df(2L)Adh-nBR102
(Roote et al., 1996, Fossett et al., 1994)
Df(2L)Adh-nBR103
(Fossett et al., 1994)
Df(2L)Adh-nBR105
(Roote, 1996.1.11, Roote, 1996.8, Roote et al., 1996, Fossett et al., 1994)
Df(2L)Adh-nBR106
(Fossett et al., 1994)
Df(2L)Adh-nBR107
(Roote, 1996.1.11, Roote, 1996.8, Roote et al., 1996, Fossett et al., 1994)
Df(2L)Adh-nBR111
(Fossett et al., 1990)
Df(2L)Adh-nBR117
(Fossett et al., 1994)
Df(2L)Adh-nBR118
(Fossett et al., 1994)
Df(2L)Adh-nBR119
(Fossett et al., 1994)
Df(2L)Adh-nBR120
(Fossett et al., 1994)
Df(2L)Adh-nBR121
(Roote, 1996.1.11, Roote, 1996.8, Roote et al., 1996, Fossett et al., 1994)
Df(2L)Adh-nBR122
(Roote, 1996.1.11, Roote, 1996.8, Roote et al., 1996, Fossett et al., 1994)
Df(2L)Adh-nBR125
(Fossett et al., 1994)
Df(2L)Adh-nBR126
(Fossett et al., 1994)
Df(2L)Adh-nBR127
(Roote, 1996.1.11, Roote, 1996.8, Roote et al., 1996, Fossett et al., 1994)
Df(2L)Adh-nBR128
(Roote, 1996.1.11, Roote, 1996.8, Roote et al., 1996, Fossett et al., 1994)
Df(2L)Adh-nBR129
(Fossett et al., 1994)
Df(2L)Adh-nBR130
(Fossett et al., 1994)
Df(2L)Adh-nBR131
(Fossett et al., 1994)
Df(2L)ARR1
(Roote et al., 1996)
Df(2L)b84a1
(McNabb et al., 1996, Roote, 1996.8)
Df(2L)b84h50
(Spradling et al., 1999, BDGP Project Members, 1994-1999)
Df(2L)b88c25
(Roote, 2002.1.15, Roote, 2000.6.5, Roote, 2000.7.3)
Df(2L)b89e68
(Roote, 2002.1.15, Roote, 2000.6.5, Roote, 2000.7.3)
Df(2L)b89e88b
(Roote, 2000.6.5)
Df(2L)do1
(Ashburner et al., 1981)
Df(2L)ED3
(Ryder and Roote, 2004.11.10, Roote, 2002.2.6)
Df(2L)el77
(McNabb et al., 1996, Woodruff and Ashburner, 1979, Woodruff and Ashburner, 1979)
Df(2L)el80f1
(Ashburner et al., 1983)
Df(2L)el81i1
(Roote, 2002.1.15)
Df(2L)Exel8033
(Ryder, 2004.4.26)
Df(2L)fn1
(Grau et al., 1984, Ashburner et al., 1982, Ashburner et al., 1982, Woodruff and Ashburner, 1979, Woodruff and Ashburner, 1979)
Df(2L)fn2
(McNabb et al., 1996, Roote, 1996.8, Roote et al., 1996, Grau et al., 1984, Ashburner et al., 1982, Ashburner et al., 1982, Woodruff and Ashburner, 1979, Woodruff and Ashburner, 1979)
Df(2L)fn3
(Ashburner et al., 1982, Woodruff and Ashburner, 1979, Woodruff and Ashburner, 1979)
Df(2L)fn5
(Ashburner et al., 1982)
Df(2L)fn7
(McNabb et al., 1996, Roote, 1996.8, Ashburner et al., 1982, Woodruff and Ashburner, 1979, Woodruff and Ashburner, 1979)
Df(2L)fn12
(Ashburner et al., 1982, Woodruff and Ashburner, 1979)
Df(2L)fn15
(Ashburner et al., 1982)
Df(2L)fn26
(Ashburner et al., 1982)
Df(2L)fn27
(Ashburner et al., 1982, Ashburner et al., 1982)
Df(2L)fn30
(Ashburner et al., 1982)
Df(2L)fn31
(Ashburner et al., 1982)
Df(2L)fn36
(McNabb et al., 1996, Roote, 1996.8, Ashburner et al., 1982)
Df(2L)fn52
(McNabb et al., 1996, Roote, 1996.8, Roote et al., 1996)
Df(2L)GT5
(Gubb et al., 1990)
Df(2L)k08808-mr1
(Roote, 2002.2.18)
Df(2L)n78l3
(Ashburner et al., 1982)
Df(2L)nNxF1
(Chia et al., 1985)
Df(2L)nNxF2
(Chia et al., 1985)
Df(2L)noc10
(McNabb et al., 1996, Roote, 1996.8)
Df(2L)noc13
(McNabb et al., 1996, Roote, 1996.8)
Df(2L)noc20
(McNabb et al., 1996)
Df(2L)osp18
(Ashraf et al., 1999, McNabb et al., 1996, Roote et al., 1996)
Df(2L)osp29
(Ashraf et al., 1999, McNabb et al., 1996, Roote, 1996.8, Roote et al., 1996)
Df(2L)osp144
(McNabb et al., 1996, Roote, 1996.8, Roote et al., 1996, Ashburner et al., 1982)
Df(2L)osp201
(McNabb et al., 1996)
Df(2L)osp-204
Df(2L)PA4
(Roote, 2002.1.15, Ashburner et al., 1983)
Df(2L)Sco-2
Df(2L)Sco7
(Ashburner et al., 1983)
Df(2L)Scorv4
(Ashburner et al., 1990, Ashburner et al., 1983, Woodruff and Ashburner, 1979, Woodruff and Ashburner, 1979)
Df(2L)Scorv10
(Grau et al., 1984, Ashburner et al., 1983, Ashburner et al., 1980, Woodruff and Ashburner, 1979)
Df(2L)Scorv14
(Ashburner et al., 1983, Ashburner et al., 1980, Woodruff and Ashburner, 1979)
Df(2L)Scorv18
(Ashburner et al., 1983, Ashburner et al., 1980)
Df(2L)Scorv23
(Grau et al., 1984, Ashburner et al., 1983)
Df(2L)TE35B-1
(Gubb et al., 1985)
Df(2L)TE35B-2
(Gubb et al., 1985)
Df(2L)TE35B-3
(Gubb et al., 1985)
Df(2L)TE35B-5
(Gubb et al., 1985)
Df(2L)TE35B-6
(Gubb et al., 1985)
Df(2L)TE35B-7
(Roote et al., 1996, Gubb et al., 1985)
Df(2L)TE35B-8
(McNabb et al., 1996, Roote et al., 1996, Gubb et al., 1985)
Df(2L)TE35B-9
(McNabb et al., 1996, Roote, 1996.8, Gubb et al., 1985)
Df(2L)TE35B-11
(McNabb et al., 1996, Roote, 1996.8, Roote et al., 1996, Gubb et al., 1985)
Df(2L)TE35B-15
(McNabb et al., 1996, Roote, 1996.8, Gubb et al., 1985)
Df(2L)TE35B-48
(Gubb et al., 1997, McNabb et al., 1996, Roote, 1996.8, Gubb et al., 1986)
Df(2L)TE35B-54L
(Roote et al., 1996)
Df(2L)TE35B-54
(Gubb et al., 1997, McNabb et al., 1996, Gubb et al., 1986)
Df(2L)TE35BC-6
(Gubb et al., 1984)
Df(2L)TE35BC-7
(Gubb et al., 1984)
Df(2L)TE35BC-8
(Gubb et al., 1984)
Df(2L)TE35BC-23
(Gubb et al., 1984)
Df(2L)TE35BC-29
(Gubb et al., 1984)
Df(2L)TE35BC-31
(Gubb et al., 1984)
Df(2L)W
(McNabb et al., 1996, Roote, 1996.8, Ashburner et al., 1982, Woodruff and Ashburner, 1979, Woodruff and Ashburner, 1979)
In(2L)75cLC158.1R
(Woodruff and Ashburner, 1979, Woodruff and Ashburner, 1979)
In(2L)75c
(Grau et al., 1984, Woodruff and Ashburner, 1979, Woodruff and Ashburner, 1979)
In(2L)b88e16
(Roote, 2000.6.5)
In(2L)C158LScorv11R
(Ashburner et al., 1983)
In(2L)C158LScorv17R
(Ashburner et al., 1983)
In(2L)dppH86
(Roote et al., 1996)
In(2L)osp22
(McNabb et al., 1996, Roote et al., 1996)
In(2L)osp59
(McNabb et al., 1996, Roote et al., 1996)
In(2L)TE35B-13
(Gubb et al., 1985)
In(2LR)el6LA379R
(Roote, 2002.1.15, Roote, 1996.1.11, Roote, 1996.8, Roote et al., 1996)
In(2LR)noc4LScorv9R
(Ashburner and Harrington, 1984)
In(2LR)Scorv1LTE35B-15R
(Roote et al., 1996)
In(2LR)TE35B-4LScorv1R
(Roote, 2002.1.15)
In(2LR)TE35B-6LScorv9R
(Ashburner and Harrington, 1984)
In(2LR)TE35B-14LScorv1R
(Roote, 2002.1.15)
T(2;3)88g68
(Roote, 2000.6.5)
T(2;3)GT7
(Gubb et al., 1990)
T(2;3)H47
(McNabb et al., 1996, Roote et al., 1996)
T(2;3)Mpe
(McNabb et al., 1996)
T(2;3)osp90
(McNabb et al., 1996, Roote et al., 1996)
T(2;3)Scorv7
(Ashburner and Harrington, 1984, Grau et al., 1984, Ashburner et al., 1983, Ashburner et al., 1980, Woodruff and Ashburner, 1979, Woodruff and Ashburner, 1979)
T(2;3)TE35B-2a
(Chia et al., 1985)
T(2;3)TE35B-3DG16P
(Chia et al., 1985)
T(Y;2)A80DR15P
(Ashburner et al., 1982, Woodruff and Ashburner, 1979, Woodruff and Ashburner, 1979)
T(Y;2)GT1
(Gubb et al., 1990)
Tp(1;2)TE35B-ospA5
(Moschetti et al., 2004)
Tp(2;2)A446
(Roote et al., 1996, Fossett et al., 1994, Ashburner et al., 1982, Ashburner et al., 1982)
Tp(2;3)osp3
(McNabb et al., 1996)
Tp(2;3)pb3
(McNabb et al., 1996, Roote et al., 1996, Ashburner et al., 1981)
Tp(3;2)osp204
(Roote et al., 1996)
Ts(2Lt;3Lt)GT7+Ts(2Rt;3Rt)Scorv13
(Roote, 2002.1.15, Roote et al., 1996)
Ts(2Lt;3Lt)Mpe+Ts(2Rt;3Rt)G16
(Chia et al., 1985)
Ts(2Lt;3Lt)TE35B-4+Ts(2Rt;3Rt)Scorv13
(Chia et al., 1985, Ashburner and Harrington, 1984)
Ts(2Lt;3Lt)TE35B-28+Ts(2Rt;3Rt)osp90
(Roote et al., 1996, Roote, 1995.3.27)
Ts(2Lt;3Lt)TE35BC-3+Ts(2Rt;3Rt)Scorv13
(Ashburner et al., 1983)
Ts(2Lt;4Lt)TE35B-50+Ts(2Rt;4Rt)DTD22
(Roote, 2002.1.15)
Ts(2Lt;4Lt)TE35B-101+Ts(2Rt;4Rt)DTD22
(Roote, 2002.1.15)
Ts(Y;2Lt)el4+Ts(YSt;2Rt)R15
(Roote et al., 1996, Ashburner et al., 1982)
Ts(Y;2Lt)GT1+Ts(YSt;2Rt)R15
(Roote et al., 1996)
Ts(YLt;2Lt)G74+Ts(YSt;2Rt)B210
(Woodruff and Ashburner, 1979)
Ts(YSt;2Lt)G74+Ts(YSt;2Rt)J165
(Woodruff and Ashburner, 1979)
Ts(YSt;2Lt)G74+Ts(YSt;2Rt)P58
(Woodruff and Ashburner, 1979)
Ts(YSt;2Lt)G74+Ts(YSt;2Rt)R15
(Woodruff and Ashburner, 1979)
Gene not disrupted in
Df(2L)A48
(Spradling et al., 1999, BDGP Project Members, 1994-1999)
Df(2L)b75
(Gubb et al., 1990, Woodruff and Ashburner, 1979, Woodruff and Ashburner, 1979)
Df(2L)b80e3
(Roote et al., 1996, Ashburner et al., 1982)
Df(2L)b81a1
(Roote et al., 1996, Ashburner et al., 1982)
Df(2L)b83d29a
(Roote et al., 1996)
Df(2L)b84a2
(Roote et al., 1996)
Df(2L)b84a4
(Roote, 2000.7.3, McNabb et al., 1996, Roote et al., 1996)
Df(2L)b84a8
(Roote, 2000.7.3, McNabb et al., 1996)
Df(2L)b88h49
(Roote et al., 1996)
Df(2L)el14
(Roote et al., 1996)
Df(2L)GT4
(McNabb et al., 1996, Gubb et al., 1990)
Df(2L)osp29
(Chia et al., 1985, Grau et al., 1984, Ashburner et al., 1982)
Df(2L)Sco-1
(Ashburner, 1982)
Df(2L)Scorv16
(Grau et al., 1984, Ashburner et al., 1983)
Df(2L)Scorv19
(Grau et al., 1984, Ashburner et al., 1983)
Df(2L)Scorv25
(Grau et al., 1984, Ashburner et al., 1983)
Df(2L)SS1
(Grau et al., 1984)
Df(2L)TE35B-4
(Gubb et al., 1985)
Df(2L)TE35B-10
(Gubb et al., 1985)
Df(2L)TE35B-12
(Roote, 1996.8, Roote et al., 1996, Gubb et al., 1985)
Df(2L)TE35B-203
(Roote, 2002.1.15)
Df(2L)TE35B-300
(Roote et al., 1996)
Df(2L)TE35BC-1
(Gubb et al., 1984)
Df(2L)TE35BC-3
(Grau et al., 1984, Gubb et al., 1984, Ashburner et al., 1982)
Df(2L)TE35BC-4
(McNabb et al., 1996, Roote et al., 1996, Gubb et al., 1984, Ashburner et al., 1982)
Df(2L)TE35BC-24
(Gubb et al., 1984)
Df(2L)TE35BC-28
(McNabb et al., 1996, Gubb et al., 1984)
Df(2L)TE35BC-34
(Roote, 1996.8, Gubb et al., 1984)
Df(2L)TE35BC-35
(McNabb et al., 1996, Gubb et al., 1984)
Dp(2;2)Cam12
(Roote et al., 1996)
In(2L)C158LScorv11R
(Ashburner and Harrington, 1984, Ashburner et al., 1981)
In(2L)C158LScorv17R
(Ashburner and Harrington, 1984)
In(2L)C158
(McNabb et al., 1996, Roote et al., 1996)
In(2L)Scorv11
(Roote et al., 1996)
In(2L)Scorv17
(Roote et al., 1996)
In(2LR)b81a2LDTD43R
(Roote, 2002.1.15, Roote, 2000.7.3)
In(2LR)D20Lnoc4R
(Roote et al., 1996)
In(2LR)noc4LTE35B-50R
(Roote, 2002.1.15)
T(2;3)GT7
(Roote et al., 1996)
T(2;3)TE35BC-3
(McNabb et al., 1996, Roote et al., 1996)
T(Y;2)GT1
(Roote et al., 1996)
T(Y;2)J165DP58P
(Woodruff and Ashburner, 1979, Woodruff and Ashburner, 1979)
T(Y;2)R15DJ165P
(Woodruff and Ashburner, 1979, Woodruff and Ashburner, 1979)
Ts(2Lt;3Lt)dpps19+Ts(2Rt;3Rt)el24
(Roote et al., 1996)
Ts(2Lt;3Lt)H118+Ts(2Rt;3Rt)TE35B-8
(Roote, 2002.1.15)
Ts(2Lt;3Lt)H147+Ts(2Rt;3Rt)TE35B-8
(Roote, 2002.1.15)
Ts(2Lt;3Lt)TE35B-4+Ts(2Rt;3Rt)Scorv13
(Roote, 2002.1.15)
Ts(2Lt;3Lt)TE35BC-3+Ts(2Rt;3Rt)Scorv13
(McNabb et al., 1996, Ashburner and Harrington, 1984)
Ts(2Lt;3Rt)GT10+Ts(2Rt;3Lt)TE35B-209
(Roote et al., 1996)
Ts(2Lt;4Lt)GT6+Ts(2Rt;4Rt)TE35B-101
(Roote, 2002.1.15)
Ts(Y;2Lt)el4+Ts(YSt;2Rt)A80
(Roote et al., 1996)
Ts(Y;2Lt)GT2+Ts(YSt;2Rt)A80
(Roote et al., 1996)
Ts(YSt;2Lt)G74+Ts(YSt;2Rt)A80
(Woodruff and Ashburner, 1979)
Gene not duplicated in
In(2L)C163.41LC158R
(Roote et al., 1996, Ashburner et al., 1982)
In(2LR)TE35B-226LDTD128R
(Roote et al., 1996)
Ts(2Lt;4Lt)TE35B-101+Ts(2Rt;4Rt)GT6
(Roote et al., 1996)
Ts(Y;2Lt)TE35B-18+Ts(YSt;2Rt)A80
(Roote et al., 1996)
Ts(YLt;2Lt)A80+Ts(Y;2Rt)el4
(Roote et al., 1996)
Ts(YLt;2Lt)A80+Ts(YLt;2Rt)G74
(Roote et al., 1996)
Gene duplicated in
Dp(2;1)Scorv23
(Grau et al., 1984, Ashburner et al., 1983)
Dp(2;2)TE35B-54L
(Roote et al., 1996)
In(2L)C163.41LTE35B-210R
(Roote et al., 1996)
In(2LR)Scorv1LTE35B-4R
(Roote et al., 1996)
In(2LR)Scorv1LTE35B-14R
(Roote et al., 1996)
Ts(2Lt;3Lt)G16+Ts(2Rt;3Rt)TE35B-3
(Roote et al., 1996)
Ts(2Lt;4Lt)DTD22+Ts(2Rt;4Rt)TE35B-50
(Roote et al., 1996)
Ts(YLt;2Lt)R15+Ts(Y;2Rt)el4
(Roote et al., 1996)
Ts(YLt;2Lt)R15+Ts(Y;2Rt)TE35B-18
(Roote et al., 1996)
Ts(YLt;2Lt)R15+Ts(YSt;2Rt)A80
(Roote et al., 1996)
Inferred from location ( 6 )
Variants
Variant Molecular Consequences
Alleles Representing Disease-Implicated Variants
Phenotypes
Orthologs
Downloads
Download All DIOPT Orthologs
Human Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Homo sapiens (Human) (28)
Hsap\MPRIP
10 of 14
Yes
Yes
Hsap\TRIOBP
6 of 14
No
Yes
Hsap\ACAP2
1 of 14
No
No
Hsap\AKT1
1 of 14
No
No
1  
Hsap\AKT2
1 of 14
No
No
5  
Hsap\ARHGAP22
1 of 14
No
No
Hsap\ARHGAP24
1 of 14
No
No
1  
Hsap\ARHGAP25
1 of 14
No
No
Hsap\CYTH1
1 of 14
No
No
1  
Hsap\CYTH2
1 of 14
No
No
Hsap\CYTH3
1 of 14
No
No
Hsap\CYTH4
1 of 14
No
No
Hsap\DAPP1
1 of 14
No
Yes
Hsap\GAB1
1 of 14
No
No
0  
Hsap\GAB3
1 of 14
No
No
Hsap\IPCEF1
1 of 14
No
No
Hsap\MYO10
1 of 14
No
No
Hsap\PHETA1
1 of 14
No
No
1  
Hsap\PLEK2
1 of 14
No
Yes
Hsap\PLEKHA1
1 of 14
No
Yes
Hsap\PLEKHA2
1 of 14
No
Yes
Hsap\PLEKHA5
1 of 14
No
No
Hsap\PLEKHA6
1 of 14
No
No
Hsap\PLEKHA7
1 of 14
No
No
Hsap\PLEKHH1
1 of 14
No
No
Hsap\PLEKHH2
1 of 14
No
No
Hsap\PLEK
1 of 14
No
Yes
Hsap\RASGRF1
1 of 14
No
No
Model Organism Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Rattus norvegicus (Norway rat) (2)
Rnor\Mprip
9 of 14
Yes
Yes
Rnor\Triobp
5 of 14
No
Yes
Mus musculus (laboratory mouse) (2)
Mmus\Mprip
9 of 14
Yes
Yes
Mmus\Triobp
6 of 14
No
Yes
Xenopus tropicalis (Western clawed frog) (11)
Xtro\mprip
5 of 13
Yes
Yes
Xtro\triobp
3 of 13
No
Yes
Xtro\acap3
1 of 13
No
No
Xtro\aldh3b2
1 of 13
No
No
Xtro\cyth1
1 of 13
No
No
Xtro\dapp1
1 of 13
No
Yes
Xtro\myo10.2
1 of 13
No
No
Xtro\plekha1
1 of 13
No
Yes
Xtro\plekha4
1 of 13
No
No
Xtro\ppp1r16a
1 of 13
No
No
Xtro\rasgrf2
1 of 13
No
Yes
Danio rerio (Zebrafish) (4)
Drer\mprip
8 of 14
Yes
Yes
Drer\triobpa
8 of 14
Yes
Yes
Drer\si:ch73-103b11.2
6 of 14
No
Yes
Drer\triobpb
6 of 14
No
Yes
Caenorhabditis elegans (Nematode, roundworm) (1)
Cele\F10G8.8
9 of 14
Yes
Yes
Anopheles gambiae (African malaria mosquito) (8)
Agam\AgaP_AGAP009847
6 of 12
Yes
Yes
Agam\AgaP_AGAP009848
2 of 12
No
Yes
Agam\AgaP_AGAP000864
1 of 12
No
No
Agam\AgaP_AGAP001935
1 of 12
No
No
Agam\AgaP_AGAP002161
1 of 12
No
No
Agam\AgaP_AGAP005285
1 of 12
No
No
Agam\AgaP_AGAP007093
1 of 12
No
No
Agam\AgaP_AGAP008737
1 of 12
No
No
Arabidopsis thaliana (thale-cress) (2)
Atha\AT5G05710
1 of 13
Yes
No
Atha\PH1
1 of 13
Yes
No
Saccharomyces cerevisiae (Brewer's yeast) (0)
Schizosaccharomyces pombe (Fission yeast) (0)
Escherichia coli (enterobacterium) (0)
Other Organism Orthologs (via OrthoDB)
Data provided directly from OrthoDB:osp. Refer to their site for version information.
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v9.1)
Gene Symbol
Score
Source
Compara
Domainoid
eggNOG
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Drosophila melanogaster (Fruit fly) (5)
CG43867
1 of 13
IPIP
1 of 13
kmr
1 of 13
Osbp
1 of 13
step
1 of 13
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 1 )
    Modifiers Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Interaction
    References
    Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    MPRIP; myosin phosphatase Rho interacting protein
    10 of 14
    612935
        TRIOBP; TRIO and F-actin binding protein
        6 of 14
        609761
        Functional Complementation Data
        Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
        Interactions
        Summary of Physical Interactions
        Interaction Browsers
        Summary of Genetic Interactions
        Interaction Browsers
        View in FlyBase Interactions Browser   View in MIST tool (external link)
        Please look at the allele data for full details of the genetic interactions
        Starting gene(s)
        Interaction type
        Interacting gene(s)
        Reference
        osp
        enhanceable
        Dcr-2
        (Dietzl et al., 2007)
        Starting gene(s)
        Interaction type
        Interacting gene(s)
        Reference
        External Data
        Linkouts
        BioGRID - A database of protein and genetic interactions.
        DroID - A comprehensive database of gene and protein interactions.
        Pathways
        Signaling Pathways (FlyBase)
        Metabolic Pathways
        FlyBase
        External Links
        External Data
        Linkouts
        Class of Gene
        Genomic Location and Detailed Mapping Data
        Chromosome (arm)
        2L
        Recombination map
        2-50
        Cytogenetic map
        35B3-35B4
        Sequence location
        FlyBase Computed Cytological Location
        Cytogenetic map
        Evidence for location
        35B3-35B4
        Limits computationally determined from genome sequence between P{EP}elBEP2039&P{PZ}osprJ571 and P{lacW}Su(H)k07904
        Experimentally Determined Cytological Location
        Cytogenetic map
        Notes
        References
        35B1-35B4
        (determined by in situ hybridisation) 35B3--5 (determined by in situ hybridisation)
        (Ashburner et al., 1999)
        35B1-35B4
        (determined by in situ hybridisation)
        (Spradling et al., 1999)
        35B1-35B4
        (BDGP Project Members, 1994-1999)
        Experimentally Determined Recombination Data
        Location

        2-50

        (FlyBase, 2016)

        2-47.1

        (Comeron et al., 2012)

        2-50.1

        Left of (cM)
        (Lindsley and Zimm, 1992)
        (Woodruff and Ashburner, 1979)
        (Sturtevant, 1948)
        Right of (cM)
        (Woodruff and Ashburner, 1979)
        (Sturtevant, 1948)
        Notes

        Maps very near b.

        (Sturtevant, 1948)
        Stocks and Reagents
        Stocks (26)
        Genomic Clones (45)
        cDNA Clones (120)
         

        Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

        cDNA clones, fully sequenced
        BDGP DGC clones
        Other clones
        Drosophila Genomics Resource Center cDNA clones

        For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

        cDNA Clones, End Sequenced (ESTs)
        BDGP DGC clones
        Other clones
        RNAi and Array Information
        Linkouts
        DRSC - Results frm RNAi screens
        Antibody Information
        Laboratory Generated Antibodies
         
        Commercially Available Antibodies
         
        Cell Line Information
        Publicly Available Cell Lines
         
          Other Stable Cell Lines
           
            Other Comments

            osp is not a vital gene.

            (Ashburner et al., 1999)

            Adh and Adhr are nested within osp and osp has a transcription unit greater than 74kb.

            (McNabb et al., 1996)
            Relationship to Other Genes
            Source for database merge of

            Source for merge of: osp anon-WO02059370.75

            (FlyBase, 1996-)
            Additional comments

            " BG:DS09219.1 " is located within osp and is predicted to be transcribed in the same direction as osp. It may therefore be part of the osp gene, if osp has an alternative transcript that has not yet been identified as a cDNA.

            (Ashburner et al., 1999)

            Source for merge of osp anon-WO02059370.75 was sequence comparison ( date:051113 ).

            (FlyBase, 1996-)

            Since "osp" is very near the 2L breakpoint of T(2;3)Mpe, the "Mpe1" phenotype may be due to a dominant "osp" allele.

            (Ashburner et al., 1981)

            Allelism of osp and alw assumed on basis of phenotype and map position (Ashburner).

            Nomenclature History
            Source for database identify of

            Source for identity of: osp CG3479

            (Kodira, 1999.11)
            Nomenclature comments
            Etymology
            Synonyms and Secondary IDs (12)
            Datasets (0)
            Study focus (0)
            Experimental Role
            Project
            Project Type
            Title
            Study result (0)
            Result
            Result Type
            Title
            External Crossreferences and Linkouts ( 73 )
            Sequence Crossreferences
            NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
            GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
            GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
            RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
            UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.
            UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
            Other crossreferences
            AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.
            BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
            DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
            EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
            FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
            FlyMine - An integrated database for Drosophila genomics
            InterPro - A database of protein families, domains and functional sites
            KEGG Genes - Molecular building blocks of life in the genomic space.
            MARRVEL_MODEL - MARRVEL (model organism gene)
            Linkouts
            BioGRID - A database of protein and genetic interactions.
            Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
            DroID - A comprehensive database of gene and protein interactions.
            DRSC - Results frm RNAi screens
            Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
            FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
            FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
            Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
            Flygut - An atlas of the Drosophila adult midgut
            iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
            References (113)