Gene Dmel\ovo

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General Information

Symbol

Dmel\ovo

Species

D. melanogaster

Name

ovo

Annotation symbol

CG6824

Feature type

protein_coding_gene

FlyBase ID

FBgn0003028

Created / Updated

2005-09-09/2005-09-09

Genomic Location

Chromosome (arm)

Recombination map

1-10.2

Cytogenetic map

4E2-4E2

Sequence location

X:4,942,330..4,963,878 [+]

Map ( GBrowse )

Summary Information

Automatically generated summary

See sections below for more information

This gene is referred to in FlyBase by the symbol ovo (CG6824, FBgn0003028). It has the cytological map location 4E2. Its sequence location is X:4942330..4963878. Its molecular function is described as: sequence-specific DNA binding; DNA binding; RNA polymerase II transcription factor activity; zinc ion binding. It is involved in the biological processes: cuticle pattern formation; cuticle pigmentation; epidermal cell differentiation; non-sensory hair organization and biogenesis; regulation of transcription; pheromone metabolic process; female germ-line sex determination; cuticle development; oogenesis. 185 alleles are reported. The phenotypes of these alleles are annotated with 33 unique terms, many of which group under: organ system; adult segment; peripheral nervous system; cuticle; nervous system; egg; antennal segment; integumentary system; embryonic tagma; cell part. It has 4 annotated transcripts and 4 annotated polypeptides.

External Summaries

Phenotypic Description from the Red Book (Lindsley & Zimm 1992)

Gene/Allele symbols may differ from current usage

ovo: ovo (B. Oliver)

All ovo alleles fully penetrant for female sterility; no male function for ovo+ known. Lack of zygotic activity results in complete absence of germ-line cells in adult female; reduction in numbers of germ cells first evident during early gastrulation. Homozygotes for weaker alleles produce germ cells, but oogenesis defective; egg chambers may degenerate prior to vitellogenesis or proceed through oogenesis and be oviposited, depending on allele; laid eggs are permeable to neutral red and never develop. Heterozygotes for two of the dominant alleles phenotypically similar to homozygotes for weak recessive alleles. Ovarian tumors formed in females carrying ovoD3 in heterozygous combination with the hypomorphic alleles, e.g., ovoD1rv20, or with fs(1)A1621. The ovoD2 mutation is partially suppressed by many Sxl alleles. ovoD1/+ females produce no eggs; extensively utilized in the selection of ovo+ germ-line clones.

svb: shaven baby

Homozygous lethal. Many fewer denticles than wild type; remaining denticles small and with characteristic morphology. Denticles arranged in belts in the abdominal segments; absent from thoracic segments. Cell autonomous in mosaics; useful in studying embryonic mosaics.

Detailed Mapping Data

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

4E2-4E2

Limits computationally determined from genome sequence between P{EP}EP425 and P{EP}CG3249^EP1400

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

4E1-4E2

(determined by in situ hybridisation)

(Garfinkel et al., 1992)

4E1-4E2

(determined by in situ hybridisation)

(Mevel-Ninio et al., 1989)

Experimentally Determined Recombination Data

Location

1-10.2

(Mohler, 1977)

Left of (cM)

(Mohler, 1977)

Right of (cM)

(Mohler, 1977)

Notes

Molecular Map Data

Gene Order (in direction of increasing cytology)

References

Gene Order (overall orientation not stated)

References

Gene Model & Products

Please see the GBrowse view of Dmel\ovo for information on other features

Comments on Gene Model

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Associated CDS (aa)

ovo-RA

FBtr0070740

NM_080338

4710

975

ovo-RB

FBtr0070738

NM_167026

5503

1351

ovo-RC

FBtr0070739

NM_167027

4282

1222

ovo-RD

FBtr0100408

NM_001038742

5021

1028

Additional Transcript Data & Comments

Reported size (kB)

5.0, 4.8 (northern blot)

(Mevel-Ninio et al., 1991)

5.0 (northern blot)

(Garfinkel et al., 1994)

Comments

The ovo transcript has at least 3 exons and 2 introns.

(Garfinkel et al., 1994)

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kD)

Length (aa)

Theoretical pI

RefSeq ID

GenBank protein

ovo-PA

FBpp0070708

104.8

975

7.31

NP_525077

AAF46002

ovo-PB

FBpp0070706

146.8

1351

7.04

NP_726971

AAF46001

ovo-PC

FBpp0070707

132.4

1222

6.99

NP_726972

AAF46003

ovo-PD

FBpp0099822

110.7

1028

7.36

NP_001033831

ABC67174

Additional Polypeptide Data & Comments

Reported size (kD)

131 (kD predicted)

(Mevel-Ninio et al., 1991)

1028, 850 (aa); 110.6, 92 (kD predicted)

(Garfinkel et al., 1994)

Comments

The ovo protein is at least 1209 amino acids long. In addition to four zinc finger repeats, the protein contains homopolymeric runs of several different amino acids, and has an extremely hydrophilic amino acid profile.

(Mevel-Ninio et al., 1991)

External Data

Linkouts

PANTHER - Protein classification by function, families, and pathways

•

FBgn0003028

Crossreferences

InterPro domains - A database of protein families, domains, and functional sites

•

Zinc finger, C2H2-like (IPR015880)

Zinc finger, C2H2-type (IPR007087)

TRANSFAC - Eukaryotic transcription factors, their genomic binding sites, and DNA-binding profiles

•

T00669

Sequences Consistent with the Gene Model

DDBJ /
EMBL /
GenBank

DNA sequence

Protein sequence

Name

P51521

UniProtKB/TrEMBL

Maps to

Does NOT map to

Identified with

LD47350

(BDGP Project Members, 2000-, Delon et al., 2003)

RE46053

(BDGP Project Members, 2000-)

D1040

(BDGP Project Members, 1994-1999)

Mapped Features & Mutations

Please see GBrowse or insertion reports for information on insertions of transgenic constructs and features not listed here

Type

Symbol & Location

Additional Notes

References

protein binding site

ovo-protein_bind-1
X:4,958,175..4,958,199