A Database of Drosophila Genes & Genomes

FB2008_07, released August 8, 2008
 

Gene Dmel\ovo

General Information
SymbolDmel\ovoSpeciesD. melanogaster
NameovoAnnotation symbolCG6824
Feature typeprotein_coding_geneFlyBase IDFBgn0003028
Created / Updated2005-09-09/2005-09-09
Genomic Location
Chromosome (arm)XRecombination map1-10.2
Cytogenetic map4E2-4E2Sequence locationX:4,942,330..4,963,878 [+]
Map ( GBrowse ) detailed view
hide Summary Information
Automatically generated summary

See sections below for more information
This gene is referred to in FlyBase by the symbol ovo (CG6824, FBgn0003028). It has the cytological map location 4E2. Its sequence location is X:4942330..4963878. Its molecular function is described as: sequence-specific DNA binding; DNA binding; RNA polymerase II transcription factor activity; zinc ion binding. It is involved in the biological processes: cuticle pattern formation; cuticle pigmentation; epidermal cell differentiation; non-sensory hair organization and biogenesis; regulation of transcription; pheromone metabolic process; female germ-line sex determination; cuticle development; oogenesis. 185 alleles are reported. The phenotypes of these alleles are annotated with 33 unique terms, many of which group under: organ system; adult segment; peripheral nervous system; cuticle; nervous system; egg; antennal segment; integumentary system; embryonic tagma; cell part. It has 4 annotated transcripts and 4 annotated polypeptides.

External Summaries
hide Phenotypic Description from the Red Book (Lindsley & Zimm 1992)
Gene/Allele symbols may differ from current usage
ovo: ovo (B. Oliver)
All ovo alleles fully penetrant for female sterility; no male function for ovo+ known. Lack of zygotic activity results in complete absence of germ-line cells in adult female; reduction in numbers of germ cells first evident during early gastrulation. Homozygotes for weaker alleles produce germ cells, but oogenesis defective; egg chambers may degenerate prior to vitellogenesis or proceed through oogenesis and be oviposited, depending on allele; laid eggs are permeable to neutral red and never develop. Heterozygotes for two of the dominant alleles phenotypically similar to homozygotes for weak recessive alleles. Ovarian tumors formed in females carrying ovoD3 in heterozygous combination with the hypomorphic alleles, e.g., ovoD1rv20, or with fs(1)A1621. The ovoD2 mutation is partially suppressed by many Sxl alleles. ovoD1/+ females produce no eggs; extensively utilized in the selection of ovo+ germ-line clones.
svb: shaven baby
Homozygous lethal. Many fewer denticles than wild type; remaining denticles small and with characteristic morphology. Denticles arranged in belts in the abdominal segments; absent from thoracic segments. Cell autonomous in mosaics; useful in studying embryonic mosaics.
hide Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map
Evidence for location
4E2-4E2  
Limits computationally determined from genome sequence between P{EP}EP425 and P{EP}CG3249EP1400  
Experimentally Determined Cytological Location
Cytogenetic map
Notes
References
4E1-4E2
(determined by in situ hybridisation)  
4E1-4E2
(determined by in situ hybridisation)  
Experimentally Determined Recombination Data
Location
1-10.2
 
Left of (cM)
Right of (cM)
Notes
Molecular Map Data
Gene Order (in direction of increasing cytology)
References
Gene Order (overall orientation not stated)
References
hide Gene Model & Products
Please see the GBrowse view of Dmel\ovo for information on other features
detailed view FBtr0070738 FBtr0070739 FBtr0100408 FBtr0070740 FBpp0070706 FBpp0070707 FBpp0099822 FBpp0070708 FBti0056221 FBti0071754 FBti0021431 FBti0071821 FBti0055024 FBti0067684 FBti0052774 FBti0053749 FBti0039081 FBti0036830
Comments on Gene Model
hide Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Associated CDS (aa)
FBtr0070740
  4710
  975
FBtr0070738
  5503
  1351
FBtr0070739
  4282
  1222
FBtr0100408
  5021
  1028
Additional Transcript Data & Comments
Reported size (kB)
5.0, 4.8 (northern blot)
5.0 (northern blot)
Comments
The ovo transcript has at least 3 exons and 2 introns.
External Data
Crossreferences
hide Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kD)
Length (aa)
Theoretical pI
RefSeq ID
GenBank protein
ovo-PA  
FBpp0070708  
104.8  
975  
7.31  
ovo-PB  
FBpp0070706  
146.8  
1351  
7.04  
ovo-PC  
FBpp0070707  
132.4  
1222  
6.99  
ovo-PD  
FBpp0099822  
110.7  
1028  
7.36  
Additional Polypeptide Data & Comments
Reported size (kD)
131 (kD predicted)
1028, 850 (aa); 110.6, 92 (kD predicted)
Comments
The ovo protein is at least 1209 amino acids long. In addition to four zinc finger repeats, the protein contains homopolymeric runs of several different amino acids, and has an extremely hydrophilic amino acid profile.
External Data
Linkouts
PANTHER - Protein classification by function, families, and pathways
Crossreferences
InterPro domains - A database of protein families, domains, and functional sites
TRANSFAC - Eukaryotic transcription factors, their genomic binding sites, and DNA-binding profiles
  • T00669
hide Sequences Consistent with the Gene Model
DDBJ /
EMBL /
GenBank
DNA sequence
Protein sequence
Name
 
 
 
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL
    Maps to
    Does NOT map to
    Identified with
    hide Mapped Features & Mutations
    Please see GBrowse or insertion reports for information on insertions of transgenic constructs and features not listed here
    Type
    Symbol & Location
    Additional Notes
    References
    protein binding site
    ovo-protein_bind-1
    X:4,958,175..4,958,199
    bound_moiety=ovo-XP
    evidence=experimental
    protein binding site
    ovo-protein_bind-2
    X:4,957,672..4,957,690
    bound_moiety=ovo-XP
    evidence=experimental
    protein binding site
    ovo-protein_bind-3
    X:4,958,259..4,958,281
    bound_moiety=ovo-XP
    evidence=experimental
    protein binding site
    ovo-protein_bind-4
    X:4,958,020..4,958,042
    bound_moiety=ovo-XP
    evidence=experimental
    protein binding site
    ovo-protein_bind-5
    X:4,958,346..4,958,364
    bound_moiety=ovo-XP
    evidence=experimental
    protein binding site
    ovo-protein_bind-6
    X:4,957,951..4,957,979
    bound_moiety=ovo-XP
    evidence=experimental
    hide External Data
    Linkouts
    DEDB - Drosophila exon database: splicing graphs
    Crossreferences
    hide Expression Data
    FlyBase-Curated Data
    Transcript and
    Protein data
    Please see the FlyBase Gene Expression Report for details of gene expression from the literature.
    hide Summary of Transcript Expression
    Stage
    Tissue/Position
    Reference
     oogenesis stage | stage 8
     embryonic stage | cellular blastoderm
     embryonic stage | stage 14
     dorsal hair
     embryonic stage | stage 10-11
     embryonic labial segment
     embryonic stage | stage 13 | late
     dorsal hair
     embryonic stage | stage 13 | late
     denticle belt
     embryonic stage | stage 10
     embryonic stage | stage 17
     embryonic stage | stage 14
     denticle belt | restricted
     embryonic stage | mid
     embryonic stage | stage 8
     cephalic furrow | restricted
     embryonic stage | stage 1-2
     embryonic stage | stage 12 | late
     intercalary segment
     embryonic stage | stage 6
     embryonic stage | stage 13 | late
     stomatogastric nervous system
     embryonic stage | stage 12 | late
     oogenesis stage | unfertilized egg
     embryonic stage | cellular blastoderm
     oogenesis stage
     egg chamber | early
     embryonic stage | syncytial blastoderm
     embryonic stage | stage 13 | late
     dorsal ridge
     oogenesis stage,adult stage | stage S10
     nurse cell | restricted
     embryonic stage | stage 6
     embryonic stage | early
     oogenesis stage,adult stage | stage 10
     oogenesis stage,adult stage
     embryonic stage | stage 10
     embryonic/larval pharynx
     oogenesis stage,adult stage | stage 10
     follicle cell
     embryonic stage | stage 5-8
     embryonic stage | early
    Marker for
      Subcellular Localization
      CV Term
      hide Summary of Polypeptide Expression
      Stage
      Tissue/Position
      Reference
       embryonic stage | stage 17
       germ cell | nucleus
       oogenesis stage,adult stage
       female germline stem cell
       larval stage | first instar
       oogenesis stage,larval stage | second instar
       female germline stem cell | restricted
       embryonic stage | stage 8-14
       oogenesis stage,larval stage | first instar
       female germline stem cell
       adult stage,spermatogenesis
       male germline stem cell
       oogenesis stage,adult stage | stage 8
       embryonic stage | blastoderm
       oogenesis stage,adult stage | stage 10
       oogenesis stage,larval stage | third instar
       female germline stem cell | restricted
      Marker for
        Subcellular Localization
        CV Term
        hide Microarray Data
        Developmental timecourse, Costello et al., 2008 (Original data from Arbeitman et al., 2002)
        Untitled Document detailed view FBtr0070738 FBtr0070739 FBtr0100408 FBtr0070740
        hide External Data & Images
        Linkouts
        FLIGHT - Cell culture data for RNAi and other high-throughput technologies
        FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
        GEO (NCBI) - Gene expression data: microarray and other high-throughput technologies
        FlyExpress - Embryonic expression images (BDGP data)
        hide Alleles & Phenotypes
        hide Summary of Allele Phenotypes
        Lethality
        Allele
        Other Phenotypes
        Allele
        Sterility
        Allele
        Phenotype manifest in
        Allele