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Gene Dmel\ovo

General Information
Symbol	Dmel\ovo	Species	D. melanogaster
Name	ovo	Annotation symbol	CG6824
Feature type	protein_coding_gene	FlyBase ID	FBgn0003028
Gene Model Status	Current	Stock availability	46 publicly available
Also Known As	svb, ovo/svb, CG15467, ovoD
Genomic Location
Chromosome (arm)	X	Recombination map	1-10.2
Cytogenetic map	4E2-4E2	Sequence location	X:4,942,330..4,964,962 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene ovo is referred to in FlyBase by the symbol Dmel\ovo (CG6824, FBgn0003028). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: sequence-specific DNA binding; DNA binding. There is experimental evidence that it is involved in the biological process: pheromone metabolic process; cuticle pigmentation; non-sensory hair organization; positive regulation of transcription from RNA polymerase II promoter; cuticle pattern formation; germ-line sex determination; negative regulation of transcription from RNA polymerase II promoter; adult feeding behavior; epidermal cell differentiation; imaginal disc-derived leg joint morphogenesis. 197 alleles are reported. The phenotypes of these alleles are annotated with: organ system; adult segment; organ system subdivision; acellular anatomical structure; external compound sense organ; cell part; appendage segment; portion of tissue; cytoplasmic part; embryonic/larval integumentary system. It has 5 annotated transcripts and 5 annotated polypeptides. Protein features are: Zinc finger C2H2-type/integrase DNA-binding domain; Zinc finger, C2H2; Zinc finger, C2H2-like. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of low expression. Peak expression observed within 00-06 hour embryonic stages. Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: adult ovary. Expression at moderate levels in the following post-embryonic organs or tissues: larval central nervous system, adult crop, adult hindgut, adult salivary gland, larval trachea, larval carcass. Comments on Affy2 ProbeSet: ProbeSet 1627259_a_at completely aligns to an exonic region common to each of the 5 FlyBase-annotated transcript isoforms of ovo. Gene sequence location is X:4942330..4964962.
User Contributed Data
	Beta version, feedback welcome
External Summaries
Phenotypic Description from the Red Book (Lindsley & Zimm 1992)
Gene/Allele symbols may differ from current usage	ovo: ovo (B. Oliver) All ovo alleles fully penetrant for female sterility; no male function for ovo+ known. Lack of zygotic activity results in complete absence of germ-line cells in adult female; reduction in numbers of germ cells first evident during early gastrulation. Homozygotes for weaker alleles produce germ cells, but oogenesis defective; egg chambers may degenerate prior to vitellogenesis or proceed through oogenesis and be oviposited, depending on allele; laid eggs are permeable to neutral red and never develop. Heterozygotes for two of the dominant alleles phenotypically similar to homozygotes for weak recessive alleles. Ovarian tumors formed in females carrying ovoD3 in heterozygous combination with the hypomorphic alleles, e.g., ovoD1rv20, or with fs(1)A1621. The ovoD2 mutation is partially suppressed by many Sxl alleles. ovoD1/+ females produce no eggs; extensively utilized in the selection of ovo+ germ-line clones. svb: shaven baby Homozygous lethal. Many fewer denticles than wild type; remaining denticles small and with characteristic morphology. Denticles arranged in belts in the abdominal segments; absent from thoracic segments. Cell autonomous in mosaics; useful in studying embryonic mosaics.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03	Controlled Vocabulary Terms positive regulation of transposon integration
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 4E2-4E2   Limits computationally determined from genome sequence between P{EP}EP425 and P{EP}CG3249EP1400
Experimentally Determined Cytological Location
Cytogenetic map Notes References 4E1-4E2   (determined by in situ hybridisation)   (Garfinkel et al., 1992) 4E1-4E2   (determined by in situ hybridisation)   (Mevel-Ninio et al., 1989)
Experimentally Determined Recombination Data
Location	1- (Mohler, 1977) 1-10.2
Left of (cM)	cv (Mohler, 1977)
Right of (cM)	y (Mohler, 1977)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\ovo for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.43
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) ovo-RA FBtr0070740  NM_080338   4861   975 ovo-RB FBtr0070738  NM_167026   5654   1351 ovo-RC FBtr0070739  NM_167027   4433   1222 ovo-RD FBtr0100408  NM_001038742   5020   1028 ovo-RE FBtr0301914  NM_001169202   6739   1351
Additional Transcript Data & Comments
Reported size (kB)	5.0 (northern blot) (Garfinkel et al., 1994) 5.0, 4.8 (northern blot) (Mevel-Ninio et al., 1991)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein ovo-PA   FBpp0070708   104.8   975   7.31     NP_525077   AAF46002 ovo-PB   FBpp0070706   146.8   1351   7.04     NP_726971   AAF46001 ovo-PC   FBpp0070707   132.4   1222   6.99     NP_726972   AAF46003 ovo-PD   FBpp0099822   110.7   1028   7.36     NP_001033831   ABC67174 ovo-PE   FBpp0291128   146.8   1351   7.04     NP_001162673   ACZ95210
Additional Polypeptide Data & Comments
Reported size (kDa)	1028, 850 (aa); 110.6, 92 (kD predicted) (Garfinkel et al., 1994) 131 (kD predicted) (Mevel-Ninio et al., 1991)
Comments	The ovo protein is at least 1209 amino acids long. In addition to four zinc finger repeats, the protein contains homopolymeric runs of several different amino acids, and has an extremely hydrophilic amino acid profile. (Mevel-Ninio et al., 1991)
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Zinc finger, C2H2-like (IPR015880) Zinc finger, C2H2 (IPR007087) Zinc finger C2H2-type/integrase DNA-binding domain (IPR013087)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA390588   AA539881   AA696837   AA801874   AA803661   AA803779   AA817363   AA820712   AE014298 AAF46001   AE014298 AAF46002   AE014298 AAF46003   AE014298 ABC67174   AE014298 ACZ95210   AI515494   AJ430588 CAD23206   AJ430589 CAD23207   AW943894   AY094838 AAM11191   AY119649 AAM50303   BG637615   BI173564   BI242866   BI352273   BI353042   BI353842   BI354866   BI361721   BI373512   BP544848   BP544849   BP552772   BP552773   CL528277   CO187586   CO187604   CO269772   CO279834   CO284078   CO284597   CO288055   CO290407   CO291750   CO294750   CO304287   CO313722   CO315892   CO316687   CO320761   CO320952   CO322645   CO328237   CO329583   CO345125   CZ473105   CZ486607   CZ488775   CZ488776   CZ490632   EC078759   EC080514   EC083733   EC086025   EC087843   EC089324   EC196437   EC197358   EC198295   EC215376   EC229551   EC237119   EC239351   EC242012   EC247406   EC250217   EC250628   EC252679   EC259805   EV577499   EV579020   EV595739   EV598890   GH944246   GH944647   GH945207   GH945461   GH945878   GH946125   GH946548   GH952359   GH963947   GH968280   GH972053   GH981557   GH984943   S83520 AAB50918   S83520 AAB50919   U10670 CAB34880   U10671   U11383 AAB60216   X59772 CAB36921   Z83574
UniProtKB/Swiss-Prot	P51521
UniProtKB/TrEMBL	E1JJE5
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References protein binding site FBsf0000160970 X:4,958,175..4,958,199 bound_moiety=ovo-XP evidence=experimental (Lu et al., 1998, Bergman et al., 2005) protein binding site FBsf0000160971 X:4,957,672..4,957,690 bound_moiety=ovo-XP evidence=experimental (Bergman et al., 2005, Lu et al., 1998) protein binding site FBsf0000160972 X:4,958,259..4,958,281 bound_moiety=ovo-XP evidence=experimental (Lu et al., 1998, Bergman et al., 2005) protein binding site FBsf0000160973 X:4,958,020..4,958,042 bound_moiety=ovo-XP evidence=experimental (Lu et al., 1998, Bergman et al., 2005) protein binding site FBsf0000160974 X:4,958,346..4,958,364 bound_moiety=ovo-XP evidence=experimental (Lu et al., 1998, Bergman et al., 2005) protein binding site FBsf0000160975 X:4,957,951..4,957,979 bound_moiety=ovo-XP evidence=experimental (Lu et al., 1998, Bergman et al., 2005) regulatory region FBsf0000435112 X:4,859,609..4,864,870 evidence=Reporter construct (in vivo) (Frankel et al., 2010, Halfon, 2012.6.19) regulatory region FBsf0000435219 X:4,917,643..4,917,749 evidence=Reporter construct (in vivo) (Frankel et al., 2011, Halfon, 2012.6.19) regulatory region FBsf0000435301 X:4,930,385..4,936,971 evidence=Reporter construct (in vivo) (McGregor et al., 2007, Halfon, 2012.6.19) regulatory region FBsf0000435420 X:4,913,400..4,918,385 evidence=Reporter construct (in vivo) (McGregor et al., 2007, Halfon, 2012.6.19) regulatory region FBsf0000435526 X:4,914,996..4,916,037 evidence=Reporter construct (in vivo) (Frankel et al., 2011, Halfon, 2012.6.19) regulatory region FBsf0000435569 X:4,917,524..4,917,665 evidence=Reporter construct (in vivo) (Frankel et al., 2011, Halfon, 2012.6.19) regulatory region FBsf0000435949 X:4,877,367..4,881,751 evidence=Reporter construct (in vivo) (Frankel et al., 2010, Halfon, 2012.6.19) regulatory region FBsf0000435968 X:4,917,726..4,917,964 evidence=Reporter construct (in vivo) (Frankel et al., 2011, Halfon, 2012.6.19) regulatory region FBsf0000436303 X:4,959,452..4,959,806 evidence=Reporter construct (in vivo) (Bielinska et al., 2005, Halfon, 2012.6.19) regulatory region FBsf0000436412 X:4,958,228..4,958,496 evidence=Reporter construct (in vivo) (Bielinska et al., 2005, Halfon, 2012.6.19) regulatory region FBsf0000436417 X:4,917,410..4,917,749 evidence=Reporter construct (in vivo) (Frankel et al., 2011, Halfon, 2012.6.19) regulatory region FBsf0000436516 X:4,914,147..4,915,226 evidence=Reporter construct (in vivo) (Frankel et al., 2011, Halfon, 2012.6.19) regulatory region FBsf0000436784 X:4,891,752..4,896,781 evidence=Reporter construct (in vivo) (McGregor et al., 2007, Halfon, 2012.6.19)
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage | early   organism | ubiquitous   (Mevel-Ninio et al., 1991) embryonic stage 1 -- 2   organism | ubiquitous   (Mevel-Ninio et al., 1995) embryonic stage 1 -- 3   organism   (Fisher et al., 2012) Comment:maternally deposited embryonic stage 4   organism | ubiquitous   (Garfinkel et al., 1994) embryonic stage 4 -- 6   pole cell   (Fisher et al., 2012) embryonic stage 5   organism | ubiquitous   (Mevel-Ninio et al., 1991) pole cell   (Garfinkel et al., 1994, Mevel-Ninio et al., 1991) embryonic stage 5 -- 8   pole cell   (Mevel-Ninio et al., 1995) embryonic stage 6   organism | 60-80% egg length   (Mevel-Ninio et al., 1995) Comment:65-75% egg length organism | 80-90% egg length   (Mevel-Ninio et al., 1995) Comment:80-85% egg length embryonic stage 8   cephalic furrow | restricted   (Mevel-Ninio et al., 1995) embryonic stage 9 -- 12   denticle field anlage   (Payre et al., 1999) embryonic stage 10   embryonic/larval pharynx   (Mevel-Ninio et al., 1995) antenna   (Mevel-Ninio et al., 1995) embryonic stage 10 -- 11   embryonic labial segment   (Garfinkel et al., 1994) embryonic stage 11 -- 12   dorsal epidermis primordium   (Fisher et al., 2012) organism | segmentally repeated   (Fisher et al., 2012) ventral epidermis primordium   (Fisher et al., 2012) embryonic stage 12   organism | segmentally repeated   (Mevel-Ninio et al., 1995) Comment:late embryonic stage 12 intercalary segment   (Mevel-Ninio et al., 1995) Comment:late embryonic stage 12 embryonic stage 13   stomatogastric nervous system   (Garfinkel et al., 1994) Comment:late embryonic stage 13 dorsal ridge   (Garfinkel et al., 1994) Comment:late embryonic stage 13 dorsal hair   (Garfinkel et al., 1994) Comment:late embryonic stage 13 denticle belt | segmentally repeated   (Garfinkel et al., 1994) Comment:late embryonic stage 13 embryonic stage 13 -- 15   denticle field primordium   (Payre et al., 1999) embryonic stage 13 -- 16   embryonic dorsal epidermis   (Fisher et al., 2012) embryonic ventral epidermis   (Fisher et al., 2012) organism | segmentally repeated   (Fisher et al., 2012) embryonic stage 14   denticle belt | restricted   (Mevel-Ninio et al., 1995) dorsal hair   (Mevel-Ninio et al., 1995) embryonic stage 17   gonad   (Mevel-Ninio et al., 1995) denticle field   (Sucena and Stern, 2000) Comment:more pronounced in stout bristle rows than in fine hair rows adult stage & oogenesis   germarium   (Garfinkel et al., 1994) oogenesis stage S10 & adult stage | female   nurse cell   (Mevel-Ninio et al., 1991) follicle cell   (Mevel-Ninio et al., 1991) adult stage & oogenesis stage S10   nurse cell | restricted   (Garfinkel et al., 1994) oogenesis   egg chamber | early   (Garfinkel et al., 1994) oogenesis stage S8   organism   (Mevel-Ninio et al., 1991) northern blot Stage Tissue/Position (including subcellular localization) Reference embryonic stage | early     (Garfinkel et al., 1994) embryonic stage | mid     (Garfinkel et al., 1994) unfertilized egg stage   unfertilized egg   (Garfinkel et al., 1994)
Additional Descriptive Data
	At embryonic stage 9, ovo is expressed in the six rows of cells in each segment that will go on to form the six rows of denticles. (Payre et al., 1999)
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
distribution deduced from reporter Stage Tissue/Position (including subcellular localization) Reference blastoderm stage   organism | ubiquitous   (Mevel-Ninio et al., 1995) embryonic stage 8 -- 14   pole cell   (Mevel-Ninio et al., 1995) embryonic stage 17   germline cell   • nucleus (Mevel-Ninio et al., 1995) first instar larval stage   gonad   (Mevel-Ninio et al., 1995) oogenesis & first instar larval stage   female germline stem cell   (Mevel-Ninio et al., 1995) oogenesis & second instar larval stage   female germline stem cell | restricted   (Mevel-Ninio et al., 1995) oogenesis & third instar larval stage   female germline stem cell | restricted   (Mevel-Ninio et al., 1995) adult stage & oogenesis   female germline stem cell   (Mevel-Ninio et al., 1995) oogenesis stage S8 & adult stage | female   nurse cell   (Mevel-Ninio et al., 1995) oogenesis stage S10 & adult stage | female   oocyte   (Mevel-Ninio et al., 1995) spermatogenesis & adult stage   male germline stem cell   (Mevel-Ninio et al., 1995)
Additional Descriptive Data
	An ovo-:-Ecol\lacZ fusion protein (hereafter referred to as ovo protein) is detected in female germ cell nuclei early in oogenesis. The protein accumulates in nurse cell nuclei until stage 10, after which time it is seen in the oocyte nucleus. During embryogenesis, the ovo protein is at first expressed at high levels throughout the embryo, and this general expression, decreases greatly by stage 8, when the specific expression of ovo protein in pole cell nuclei becomes apparent. ovo protein expression persists in pole cell nuclei through embryonic development, and continues until the incorporation of the pole cells into the developing gonads at stage 14. From this stage onwards, ovo protein is detected in the developing gonads, and at stage 17, ovo protein staining is seen in the nuclei of the germ cells in the gonads. The ovo protein is detected in the nuclei of germ cells in female first instar larvae, but its expression becomes limited to a subpopulation of these cells in female second and third instar larvae. In male second and third instar larvae, ovo protein staining is seen in the anterior of the gonad, and in the adult male, staining is seen at the tip of the testis, in the nuclei of presumptive stem cells and cysts. (Mevel-Ninio et al., 1995)
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
nucleus inferred from direct assay (Kondo et al., 2010)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: adult ovary. Expression at moderate levels in the following post-embryonic organs or tissues: larval central nervous system, adult crop, adult hindgut, adult salivary gland, larval trachea, larval carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    105.9 Larval Midgut    7.7 Larval Hindgut    88.5 Larval Malpighian Tubules    2.1 Larval Fat Body    13.4 Larval Salivary Gland    15.3 Larval Trachea    338.9 Larval Carcass    289.55 Adult Head    48.8 Adult Eye    61.075 Adult Brain    8 Adult Thoracic-Abdominal Ganglion    5.7 Adult Crop    302.9 Adult Midgut    3.8 Adult Hindgut    131.1 Adult Malpighian Tubules    16.8 Adult Fat Body    30.6 Adult Salivary Gland    136.7 Adult Heart    7.35 Adult VirginFemale Spermatheca    59.1 Adult InseminatedFemale Spermatheca    76.5 Adult Ovary    953.3 Adult Testis    4.3 Adult Male Accessory Gland    6.4 Adult Carcass    73.8 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    105.9 Larval Midgut    7.7 Larval Hindgut    88.5 Larval Malpighian Tubules    2.1 Larval Fat Body    13.4 Larval Salivary Gland    15.3 Larval Trachea    338.9 Larval Carcass    289.55 Adult Head    48.8 Adult Eye    61.075 Adult Brain    8 Adult Thoracic-Abdominal Ganglion    5.7 Adult Crop    302.9 Adult Midgut    3.8 Adult Hindgut    131.1 Adult Malpighian Tubules    16.8 Adult Fat Body    30.6 Adult Salivary Gland    136.7 Adult Heart    7.35 Adult VirginFemale Spermatheca    59.1 Adult InseminatedFemale Spermatheca    76.5 Adult Ovary  (953.3) Adult Testis    4.3 Adult Male Accessory Gland    6.4 Adult Carcass    73.8 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    105.9 Larval Midgut    7.7 Larval Hindgut    88.5 Larval Malpighian Tubules    2.1 Larval Fat Body    13.4 Larval Salivary Gland    15.3 Larval Trachea    338.9 Larval Carcass    289.55 Adult Head    48.8 Adult Eye    61.075 Adult Brain    8 Adult Thoracic-Abdominal Ganglion    5.7 Adult Crop    302.9 Adult Midgut    3.8 Adult Hindgut    131.1 Adult Malpighian Tubules    16.8 Adult Fat Body    30.6 Adult Salivary Gland    136.7 Adult Heart    7.35 Adult VirginFemale Spermatheca    59.1 Adult InseminatedFemale Spermatheca    76.5 Adult Ovary    953.3 Adult Testis    4.3 Adult Male Accessory Gland    6.4 Adult Carcass    73.8 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    105.9 Larval Midgut    7.7 Larval Hindgut    88.5 Larval Malpighian Tubules    2.1 Larval Fat Body    13.4 Larval Salivary Gland    15.3 Larval Trachea    338.9 Larval Carcass    289.55 Adult Head    48.8 Adult Eye    61.075 Adult Brain    8 Adult Thoracic-Abdominal Ganglion    5.7 Adult Crop    302.9 Adult Midgut    3.8 Adult Hindgut    131.1 Adult Malpighian Tubules    16.8 Adult Fat Body    30.6 Adult Salivary Gland    136.7 Adult Heart    7.35 Adult VirginFemale Spermatheca    59.1 Adult InseminatedFemale Spermatheca    76.5 Adult Ovary    953.3 Adult Testis    4.3 Adult Male Accessory Gland    6.4 Adult Carcass    73.8 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    105.9 Larval Midgut    7.7 Larval Hindgut    88.5 Larval Malpighian Tubules    2.1 Larval Fat Body    13.4 Larval Salivary Gland    15.3 Larval Trachea    338.9 Larval Carcass    289.55 Adult Head    48.8 Adult Eye    61.075 Adult Brain    8 Adult Thoracic-Abdominal Ganglion    5.7 Adult Crop    302.9 Adult Midgut    3.8 Adult Hindgut    131.1 Adult Malpighian Tubules    16.8 Adult Fat Body    30.6 Adult Salivary Gland    136.7 Adult Heart    7.35 Adult VirginFemale Spermatheca    59.1 Adult InseminatedFemale Spermatheca    76.5 Adult Ovary    953.3 Adult Testis    4.3 Adult Male Accessory Gland    6.4 Adult Carcass    73.8 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    105.9 Larval Midgut    7.7 Larval Hindgut    88.5 Larval Malpighian Tubules    2.1 Larval Fat Body    13.4 Larval Salivary Gland    15.3 Larval Trachea    338.9 Larval Carcass    289.55 Adult Head    48.8 Adult Eye    61.075 Adult Brain    8 Adult Thoracic-Abdominal Ganglion    5.7 Adult Crop    302.9 Adult Midgut    3.8 Adult Hindgut    131.1 Adult Malpighian Tubules    16.8 Adult Fat Body    30.6 Adult Salivary Gland    136.7 Adult Heart    7.35 Adult VirginFemale Spermatheca    59.1 Adult InseminatedFemale Spermatheca    76.5 Adult Ovary  (953.3) Adult Testis    4.3 Adult Male Accessory Gland    6.4 Adult Carcass    73.8 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    105.9 Larval Midgut    7.7 Larval Hindgut    88.5 Larval Malpighian Tubules    2.1 Larval Fat Body    13.4 Larval Salivary Gland    15.3 Larval Trachea    338.9 Larval Carcass    289.55 Adult Head    48.8 Adult Eye    61.075 Adult Brain    8 Adult Thoracic-Abdominal Ganglion    5.7 Adult Crop    302.9 Adult Midgut    3.8 Adult Hindgut    131.1 Adult Malpighian Tubules    16.8 Adult Fat Body    30.6 Adult Salivary Gland    136.7 Adult Heart    7.35 Adult VirginFemale Spermatheca    59.1 Adult InseminatedFemale Spermatheca    76.5 Adult Ovary    953.3 Adult Testis    4.3 Adult Male Accessory Gland    6.4 Adult Carcass    73.8 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    105.9 Larval Midgut    7.7 Larval Hindgut    88.5 Larval Malpighian Tubules    2.1 Larval Fat Body    13.4 Larval Salivary Gland    15.3 Larval Trachea    338.9 Larval Carcass    289.55 Adult Head    48.8 Adult Eye    61.075 Adult Brain    8 Adult Thoracic-Abdominal Ganglion    5.7 Adult Crop    302.9 Adult Midgut    3.8 Adult Hindgut    131.1 Adult Malpighian Tubules    16.8 Adult Fat Body    30.6 Adult Salivary Gland    136.7 Adult Heart    7.35 Adult VirginFemale Spermatheca    59.1 Adult InseminatedFemale Spermatheca    76.5 Adult Ovary    953.3 Adult Testis    4.3 Adult Male Accessory Gland    6.4 Adult Carcass    73.8 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    48.8   NA  Eye    61.075   NA  Brain    8   105.9  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    5.7   NA  Crop    302.9   7.7  Midgut    3.8   88.5  Hindgut    131.1   2.1  Malpighian Tubules    no informative data   13.4  Fat Body    30.6   15.3  Salivary Gland    136.7   NA  Heart    7.35   338.9  Trachea    NA   NA  VirginFemale Spermatheca    59.1   NA  InseminatedFemale Spermatheca    76.5   NA  Ovary    953.3   NA  Testis    4.3   NA  Male Accessory Gland    6.4   289.55  Carcass    73.8 FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    18 central nervous system, larvae L3    3 central nervous system, pupae P8    1 head, virgin 1-day female    3 head, virgin 4-day female    2 head, virgin 20-day female    1 head, mated 1-day female    3 head, mated 4-day female    2 head, mated 20-day female    1 head, mated 1-day male    3 head, mated 4-day male    2 head, mated 20-day male    2 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    1 digestive system, 1-day adult    1 digestive system, 4-day adult    3 digestive system, 20-day adult    2 fat body, larvae L3 wandering    0 fat body, white prepupae    2 fat body, pupae P8    3 carcass, larvae L3 wandering    17 carcass, 1-day adult    4 carcass, 4-day adult    6 carcass, 20-day adult    4 ovary, virgin 4-day female    56 ovary, mated 4-day female    54 testis, mated 4-day male    0 accessory gland, mated 4-day male    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    18 central nervous system, larvae L3    3 central nervous system, pupae P8    1 head, virgin 1-day female    3 head, virgin 4-day female    2 head, virgin 20-day female    1 head, mated 1-day female    3 head, mated 4-day female    2 head, mated 20-day female    1 head, mated 1-day male    3 head, mated 4-day male    2 head, mated 20-day male    2 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    1 digestive system, 1-day adult    1 digestive system, 4-day adult    3 digestive system, 20-day adult    2 fat body, larvae L3 wandering    0 fat body, white prepupae    2 fat body, pupae P8    3 carcass, larvae L3 wandering    17 carcass, 1-day adult    4 carcass, 4-day adult    6 carcass, 20-day adult    4 ovary, virgin 4-day female  (56) ovary, mated 4-day female  (54) testis, mated 4-day male    0 accessory gland, mated 4-day male    0 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    18 central nervous system, larvae L3    3 central nervous system, pupae P8    1 head, virgin 1-day female    3 head, virgin 4-day female    2 head, virgin 20-day female    1 head, mated 1-day female    3 head, mated 4-day female    2 head, mated 20-day female    1 head, mated 1-day male    3 head, mated 4-day male    2 head, mated 20-day male    2 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    1 digestive system, 1-day adult    1 digestive system, 4-day adult    3 digestive system, 20-day adult    2 fat body, larvae L3 wandering    0 fat body, white prepupae    2 fat body, pupae P8    3 carcass, larvae L3 wandering    17 carcass, 1-day adult    4 carcass, 4-day adult    6 carcass, 20-day adult    4 ovary, virgin 4-day female    56 ovary, mated 4-day female    54 testis, mated 4-day male    0 accessory gland, mated 4-day male    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    18 central nervous system, larvae L3    3 central nervous system, pupae P8    1 head, virgin 1-day female    3 head, virgin 4-day female    2 head, virgin 20-day female    1 head, mated 1-day female    3 head, mated 4-day female    2 head, mated 20-day female    1 head, mated 1-day male    3 head, mated 4-day male    2 head, mated 20-day male    2 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    1 digestive system, 1-day adult    1 digestive system, 4-day adult    3 digestive system, 20-day adult    2 fat body, larvae L3 wandering    0 fat body, white prepupae    2 fat body, pupae P8    3 carcass, larvae L3 wandering    17 carcass, 1-day adult    4 carcass, 4-day adult    6 carcass, 20-day adult    4 ovary, virgin 4-day female    56 ovary, mated 4-day female    54 testis, mated 4-day male    0 accessory gland, mated 4-day male    0 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    18 central nervous system, larvae L3    3 central nervous system, pupae P8    1 head, virgin 1-day female    3 head, virgin 4-day female    2 head, virgin 20-day female    1 head, mated 1-day female    3 head, mated 4-day female    2 head, mated 20-day female    1 head, mated 1-day male    3 head, mated 4-day male    2 head, mated 20-day male    2 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    1 digestive system, 1-day adult    1 digestive system, 4-day adult    3 digestive system, 20-day adult    2 fat body, larvae L3 wandering    0 fat body, white prepupae    2 fat body, pupae P8    3 carcass, larvae L3 wandering    17 carcass, 1-day adult    4 carcass, 4-day adult    6 carcass, 20-day adult    4 ovary, virgin 4-day female    56 ovary, mated 4-day female    54 testis, mated 4-day male    0 accessory gland, mated 4-day male    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    18 central nervous system, larvae L3    3 central nervous system, pupae P8    1 head, virgin 1-day female    3 head, virgin 4-day female    2 head, virgin 20-day female    1 head, mated 1-day female    3 head, mated 4-day female    2 head, mated 20-day female    1 head, mated 1-day male    3 head, mated 4-day male    2 head, mated 20-day male    2 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    1 digestive system, 1-day adult    1 digestive system, 4-day adult    3 digestive system, 20-day adult    2 fat body, larvae L3 wandering    0 fat body, white prepupae    2 fat body, pupae P8    3 carcass, larvae L3 wandering    17 carcass, 1-day adult    4 carcass, 4-day adult    6 carcass, 20-day adult    4 ovary, virgin 4-day female  (56) ovary, mated 4-day female  (54) testis, mated 4-day male    0 accessory gland, mated 4-day male    0 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    18 central nervous system, larvae L3    3 central nervous system, pupae P8    1 head, virgin 1-day female    3 head, virgin 4-day female    2 head, virgin 20-day female    1 head, mated 1-day female    3 head, mated 4-day female    2 head, mated 20-day female    1 head, mated 1-day male    3 head, mated 4-day male    2 head, mated 20-day male    2 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    1 digestive system, 1-day adult    1 digestive system, 4-day adult    3 digestive system, 20-day adult    2 fat body, larvae L3 wandering    0 fat body, white prepupae    2 fat body, pupae P8    3 carcass, larvae L3 wandering    17 carcass, 1-day adult    4 carcass, 4-day adult    6 carcass, 20-day adult    4 ovary, virgin 4-day female    56 ovary, mated 4-day female    54 testis, mated 4-day male    0 accessory gland, mated 4-day male    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    18 central nervous system, larvae L3    3 central nervous system, pupae P8    1 head, virgin 1-day female    3 head, virgin 4-day female    2 head, virgin 20-day female    1 head, mated 1-day female    3 head, mated 4-day female    2 head, mated 20-day female    1 head, mated 1-day male    3 head, mated 4-day male    2 head, mated 20-day male    2 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    1 digestive system, 1-day adult    1 digestive system, 4-day adult    3 digestive system, 20-day adult    2 fat body, larvae L3 wandering    0 fat body, white prepupae    2 fat body, pupae P8    3 carcass, larvae L3 wandering    17 carcass, 1-day adult    4 carcass, 4-day adult    6 carcass, 20-day adult    4 ovary, virgin 4-day female    56 ovary, mated 4-day female    54 testis, mated 4-day male    0 accessory gland, mated 4-day male    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of low expression. Peak expression observed within 00-06 hour embryonic stages. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    89 embryo 02-04hr    12 embryo 04-06hr    13 embryo 06-08hr    20 embryo 08-10hr    13 embryo 10-12hr    19 embryo 12-14hr    17 embryo 14-16hr    8 embryo 16-18hr    10 embryo 18-20hr    7 embryo 20-22hr    4 embryo 22-24hr    4 larva L1    4 larva L2    3 larva L3 12hr old    2 larva L3 puffstage 1-2    2 larva L3 puffstage 3-6    6 larva L3 puffstage 7-9    7 white prepupae new    8 white prepupae 12hr    2 white prepupae 24hr    16 pupae 2d postWPP    4 pupae 3d postWPP    2 pupae 4d postWPP    5 adult male 01day    2 adult male 05day    2 adult male 30day    2 adult female 01day    37 adult female 05day    52 adult female 30day    52 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (89) embryo 02-04hr    12 embryo 04-06hr    13 embryo 06-08hr    20 embryo 08-10hr    13 embryo 10-12hr    19 embryo 12-14hr    17 embryo 14-16hr    8 embryo 16-18hr    10 embryo 18-20hr    7 embryo 20-22hr    4 embryo 22-24hr    4 larva L1    4 larva L2    3 larva L3 12hr old    2 larva L3 puffstage 1-2    2 larva L3 puffstage 3-6    6 larva L3 puffstage 7-9    7 white prepupae new    8 white prepupae 12hr    2 white prepupae 24hr    16 pupae 2d postWPP    4 pupae 3d postWPP    2 pupae 4d postWPP    5 adult male 01day    2 adult male 05day    2 adult male 30day    2 adult female 01day  (37) adult female 05day  (52) adult female 30day  (52) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    89 embryo 02-04hr    12 embryo 04-06hr    13 embryo 06-08hr    20 embryo 08-10hr    13 embryo 10-12hr    19 embryo 12-14hr    17 embryo 14-16hr    8 embryo 16-18hr    10 embryo 18-20hr    7 embryo 20-22hr    4 embryo 22-24hr    4 larva L1    4 larva L2    3 larva L3 12hr old    2 larva L3 puffstage 1-2    2 larva L3 puffstage 3-6    6 larva L3 puffstage 7-9    7 white prepupae new    8 white prepupae 12hr    2 white prepupae 24hr    16 pupae 2d postWPP    4 pupae 3d postWPP    2 pupae 4d postWPP    5 adult male 01day    2 adult male 05day    2 adult male 30day    2 adult female 01day    37 adult female 05day    52 adult female 30day    52 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    89 embryo 02-04hr    12 embryo 04-06hr    13 embryo 06-08hr    20 embryo 08-10hr    13 embryo 10-12hr    19 embryo 12-14hr    17 embryo 14-16hr    8 embryo 16-18hr    10 embryo 18-20hr    7 embryo 20-22hr    4 embryo 22-24hr    4 larva L1    4 larva L2    3 larva L3 12hr old    2 larva L3 puffstage 1-2    2 larva L3 puffstage 3-6    6 larva L3 puffstage 7-9    7 white prepupae new    8 white prepupae 12hr    2 white prepupae 24hr    16 pupae 2d postWPP    4 pupae 3d postWPP    2 pupae 4d postWPP    5 adult male 01day    2 adult male 05day    2 adult male 30day    2 adult female 01day    37 adult female 05day    52 adult female 30day    52 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    89 embryo 02-04hr    12 embryo 04-06hr    13 embryo 06-08hr    20 embryo 08-10hr    13 embryo 10-12hr    19 embryo 12-14hr    17 embryo 14-16hr    8 embryo 16-18hr    10 embryo 18-20hr    7 embryo 20-22hr    4 embryo 22-24hr    4 larva L1    4 larva L2    3 larva L3 12hr old    2 larva L3 puffstage 1-2    2 larva L3 puffstage 3-6    6 larva L3 puffstage 7-9    7 white prepupae new    8 white prepupae 12hr    2 white prepupae 24hr    16 pupae 2d postWPP    4 pupae 3d postWPP    2 pupae 4d postWPP    5 adult male 01day    2 adult male 05day    2 adult male 30day    2 adult female 01day    37 adult female 05day    52 adult female 30day    52 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (89) embryo 02-04hr    12 embryo 04-06hr    13 embryo 06-08hr    20 embryo 08-10hr    13 embryo 10-12hr    19 embryo 12-14hr    17 embryo 14-16hr    8 embryo 16-18hr    10 embryo 18-20hr    7 embryo 20-22hr    4 embryo 22-24hr    4 larva L1    4 larva L2    3 larva L3 12hr old    2 larva L3 puffstage 1-2    2 larva L3 puffstage 3-6    6 larva L3 puffstage 7-9    7 white prepupae new    8 white prepupae 12hr    2 white prepupae 24hr    16 pupae 2d postWPP    4 pupae 3d postWPP    2 pupae 4d postWPP    5 adult male 01day    2 adult male 05day    2 adult male 30day    2 adult female 01day  (37) adult female 05day  (52) adult female 30day  (52) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    89 embryo 02-04hr    12 embryo 04-06hr    13 embryo 06-08hr    20 embryo 08-10hr    13 embryo 10-12hr    19 embryo 12-14hr    17 embryo 14-16hr    8 embryo 16-18hr    10 embryo 18-20hr    7 embryo 20-22hr    4 embryo 22-24hr    4 larva L1    4 larva L2    3 larva L3 12hr old    2 larva L3 puffstage 1-2    2 larva L3 puffstage 3-6    6 larva L3 puffstage 7-9    7 white prepupae new    8 white prepupae 12hr    2 white prepupae 24hr    16 pupae 2d postWPP    4 pupae 3d postWPP    2 pupae 4d postWPP    5 adult male 01day    2 adult male 05day    2 adult male 30day    2 adult female 01day    37 adult female 05day    52 adult female 30day    52 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    89 embryo 02-04hr    12 embryo 04-06hr    13 embryo 06-08hr    20 embryo 08-10hr    13 embryo 10-12hr    19 embryo 12-14hr    17 embryo 14-16hr    8 embryo 16-18hr    10 embryo 18-20hr    7 embryo 20-22hr    4 embryo 22-24hr    4 larva L1    4 larva L2    3 larva L3 12hr old    2 larva L3 puffstage 1-2    2 larva L3 puffstage 3-6    6 larva L3 puffstage 7-9    7 white prepupae new    8 white prepupae 12hr    2 white prepupae 24hr    16 pupae 2d postWPP    4 pupae 3d postWPP    2 pupae 4d postWPP    5 adult male 01day    2 adult male 05day    2 adult male 30day    2 adult female 01day    37 adult female 05day    52 adult female 30day    52 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    0 embryonic 1182-4H    1 embryonic GM2    0 embryonic Kc167    0 embryonic S1    0 embryonic S3    0 leg disc CME L1    0 wing disc CME-W2    6 wing disc ML-DmD8    3 wing disc ML-DmD9    7 wing disc ML-DmD16-c3    25 wing disc ML-DmD21    0 wing disc ML-DmD32    1 haltere disc ML-DmD17-c3    1 eye-antennal disc ML-DmD11    22 antennal disc ML-DmD20-c5    14 mixed discs ML-DmD4-c1    5 CNS ML-DmBG1-c1    24 CNS ML-DmBG2-c2    29 tumorous blood cells mbn2    0 ovary fGS/OSS    22 ovary OSC    11 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    0 embryonic 1182-4H    1 embryonic GM2    0 embryonic Kc167    0 embryonic S1    0 embryonic S3    0 leg disc CME L1    0 wing disc CME-W2    6 wing disc ML-DmD8    3 wing disc ML-DmD9    7 wing disc ML-DmD16-c3    25 wing disc ML-DmD21    0 wing disc ML-DmD32    1 haltere disc ML-DmD17-c3    1 eye-antennal disc ML-DmD11    22 antennal disc ML-DmD20-c5    14 mixed discs ML-DmD4-c1    5 CNS ML-DmBG1-c1    24 CNS ML-DmBG2-c2  (29) tumorous blood cells mbn2    0 ovary fGS/OSS    22 ovary OSC    11 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    0 embryonic 1182-4H    1 embryonic GM2    0 embryonic Kc167    0 embryonic S1    0 embryonic S3    0 leg disc CME L1    0 wing disc CME-W2    6 wing disc ML-DmD8    3 wing disc ML-DmD9    7 wing disc ML-DmD16-c3    25 wing disc ML-DmD21    0 wing disc ML-DmD32    1 haltere disc ML-DmD17-c3    1 eye-antennal disc ML-DmD11    22 antennal disc ML-DmD20-c5    14 mixed discs ML-DmD4-c1    5 CNS ML-DmBG1-c1    24 CNS ML-DmBG2-c2    29 tumorous blood cells mbn2    0 ovary fGS/OSS    22 ovary OSC    11 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    0 embryonic 1182-4H    1 embryonic GM2    0 embryonic Kc167    0 embryonic S1    0 embryonic S3    0 leg disc CME L1    0 wing disc CME-W2    6 wing disc ML-DmD8    3 wing disc ML-DmD9    7 wing disc ML-DmD16-c3    25 wing disc ML-DmD21    0 wing disc ML-DmD32    1 haltere disc ML-DmD17-c3    1 eye-antennal disc ML-DmD11    22 antennal disc ML-DmD20-c5    14 mixed discs ML-DmD4-c1    5 CNS ML-DmBG1-c1    24 CNS ML-DmBG2-c2    29 tumorous blood cells mbn2    0 ovary fGS/OSS    22 ovary OSC    11 ovary OSS    0 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    0 embryonic 1182-4H    1 embryonic GM2    0 embryonic Kc167    0 embryonic S1    0 embryonic S3    0 leg disc CME L1    0 wing disc CME-W2    6 wing disc ML-DmD8    3 wing disc ML-DmD9    7 wing disc ML-DmD16-c3    25 wing disc ML-DmD21    0 wing disc ML-DmD32    1 haltere disc ML-DmD17-c3    1 eye-antennal disc ML-DmD11    22 antennal disc ML-DmD20-c5    14 mixed discs ML-DmD4-c1    5 CNS ML-DmBG1-c1    24 CNS ML-DmBG2-c2    29 tumorous blood cells mbn2    0 ovary fGS/OSS    22 ovary OSC    11 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    0 embryonic 1182-4H    1 embryonic GM2    0 embryonic Kc167    0 embryonic S1    0 embryonic S3    0 leg disc CME L1    0 wing disc CME-W2    6 wing disc ML-DmD8    3 wing disc ML-DmD9    7 wing disc ML-DmD16-c3    25 wing disc ML-DmD21    0 wing disc ML-DmD32    1 haltere disc ML-DmD17-c3    1 eye-antennal disc ML-DmD11    22 antennal disc ML-DmD20-c5    14 mixed discs ML-DmD4-c1    5 CNS ML-DmBG1-c1    24 CNS ML-DmBG2-c2  29 tumorous blood cells mbn2    0 ovary fGS/OSS    22 ovary OSC    11 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    0 embryonic 1182-4H    1 embryonic GM2    0 embryonic Kc167    0 embryonic S1    0 embryonic S3    0 leg disc CME L1    0 wing disc CME-W2    6 wing disc ML-DmD8    3 wing disc ML-DmD9    7 wing disc ML-DmD16-c3    25 wing disc ML-DmD21    0 wing disc ML-DmD32    1 haltere disc ML-DmD17-c3    1 eye-antennal disc ML-DmD11    22 antennal disc ML-DmD20-c5    14 mixed discs ML-DmD4-c1    5 CNS ML-DmBG1-c1    24 CNS ML-DmBG2-c2    29 tumorous blood cells mbn2    0 ovary fGS/OSS    22 ovary OSC    11 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    0 embryonic 1182-4H    1 embryonic GM2    0 embryonic Kc167    0 embryonic S1    0 embryonic S3    0 leg disc CME L1    0 wing disc CME-W2    6 wing disc ML-DmD8    3 wing disc ML-DmD9    7 wing disc ML-DmD16-c3    25 wing disc ML-DmD21    0 wing disc ML-DmD32    1 haltere disc ML-DmD17-c3    1 eye-antennal disc ML-DmD11    22 antennal disc ML-DmD20-c5    14 mixed discs ML-DmD4-c1    5 CNS ML-DmBG1-c1    24 CNS ML-DmBG2-c2    29 tumorous blood cells mbn2    0 ovary fGS/OSS    22 ovary OSC    11 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    12 cold shock, 4-day adult    8 heat shock, 4-day adult    19 Cadmium 50 mM 6 hrs, larvae L3    2 Cadmium 50 mM 12 hrs, larvae L3    3 Cadmium 50 mM 48 hrs, 4-day adult    13 Cadmium 100 mM 48 hrs, 4-day adult    32 Copper 0.5 mM 12 hrs, larvae L3    3 Copper 15 mM 48 hrs, 4-day adult    28 Zinc 5 mM 12 hrs, larvae L3    3 Zinc 4.5 mM 48 hrs, 4-day adult    9 Ethanol 2.5% 3 hrs, larvae L3    37 Ethanol 5% 3 hrs, larvae L3    2 Ethanol 10% 3 hrs, larvae L3    2 Caffeine 1.5 mg/ml 4 hrs, larvae L3    2 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    29 Caffeine 25 mg/ml 48 hrs, 4-day adult    16 Paraquat 5 mM 48 hrs, 4-day adult    27 Paraquat 10 mM 48 hrs, 4-day adult    20 Rotenone 2 μg 12 hrs, larvae L3    1 Rotenone 8 μg 12 hrs, larvae L3    1 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    12 cold shock, 4-day adult    8 heat shock, 4-day adult    19 Cadmium 50 mM 6 hrs, larvae L3    2 Cadmium 50 mM 12 hrs, larvae L3    3 Cadmium 50 mM 48 hrs, 4-day adult    13 Cadmium 100 mM 48 hrs, 4-day adult  (32) Copper 0.5 mM 12 hrs, larvae L3    3 Copper 15 mM 48 hrs, 4-day adult  (28) Zinc 5 mM 12 hrs, larvae L3    3 Zinc 4.5 mM 48 hrs, 4-day adult    9 Ethanol 2.5% 3 hrs, larvae L3  (37) Ethanol 5% 3 hrs, larvae L3    2 Ethanol 10% 3 hrs, larvae L3    2 Caffeine 1.5 mg/ml 4 hrs, larvae L3    2 Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (29) Caffeine 25 mg/ml 48 hrs, 4-day adult    16 Paraquat 5 mM 48 hrs, 4-day adult  (27) Paraquat 10 mM 48 hrs, 4-day adult    20 Rotenone 2 μg 12 hrs, larvae L3    1 Rotenone 8 μg 12 hrs, larvae L3    1 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    12 cold shock, 4-day adult    8 heat shock, 4-day adult    19 Cadmium 50 mM 6 hrs, larvae L3    2 Cadmium 50 mM 12 hrs, larvae L3    3 Cadmium 50 mM 48 hrs, 4-day adult    13 Cadmium 100 mM 48 hrs, 4-day adult    32 Copper 0.5 mM 12 hrs, larvae L3    3 Copper 15 mM 48 hrs, 4-day adult    28 Zinc 5 mM 12 hrs, larvae L3    3 Zinc 4.5 mM 48 hrs, 4-day adult    9 Ethanol 2.5% 3 hrs, larvae L3    37 Ethanol 5% 3 hrs, larvae L3    2 Ethanol 10% 3 hrs, larvae L3    2 Caffeine 1.5 mg/ml 4 hrs, larvae L3    2 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    29 Caffeine 25 mg/ml 48 hrs, 4-day adult    16 Paraquat 5 mM 48 hrs, 4-day adult    27 Paraquat 10 mM 48 hrs, 4-day adult    20 Rotenone 2 μg 12 hrs, larvae L3    1 Rotenone 8 μg 12 hrs, larvae L3    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    12 cold shock, 4-day adult    8 heat shock, 4-day adult    19 Cadmium 50 mM 6 hrs, larvae L3    2 Cadmium 50 mM 12 hrs, larvae L3    3 Cadmium 50 mM 48 hrs, 4-day adult    13 Cadmium 100 mM 48 hrs, 4-day adult    32 Copper 0.5 mM 12 hrs, larvae L3    3 Copper 15 mM 48 hrs, 4-day adult    28 Zinc 5 mM 12 hrs, larvae L3    3 Zinc 4.5 mM 48 hrs, 4-day adult    9 Ethanol 2.5% 3 hrs, larvae L3    37 Ethanol 5% 3 hrs, larvae L3    2 Ethanol 10% 3 hrs, larvae L3    2 Caffeine 1.5 mg/ml 4 hrs, larvae L3    2 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    29 Caffeine 25 mg/ml 48 hrs, 4-day adult    16 Paraquat 5 mM 48 hrs, 4-day adult    27 Paraquat 10 mM 48 hrs, 4-day adult    20 Rotenone 2 μg 12 hrs, larvae L3    1 Rotenone 8 μg 12 hrs, larvae L3    1 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    12 cold shock, 4-day adult    8 heat shock, 4-day adult    19 Cadmium 50 mM 6 hrs, larvae L3    2 Cadmium 50 mM 12 hrs, larvae L3    3 Cadmium 50 mM 48 hrs, 4-day adult    13 Cadmium 100 mM 48 hrs, 4-day adult    32 Copper 0.5 mM 12 hrs, larvae L3    3 Copper 15 mM 48 hrs, 4-day adult    28 Zinc 5 mM 12 hrs, larvae L3    3 Zinc 4.5 mM 48 hrs, 4-day adult    9 Ethanol 2.5% 3 hrs, larvae L3    37 Ethanol 5% 3 hrs, larvae L3    2 Ethanol 10% 3 hrs, larvae L3    2 Caffeine 1.5 mg/ml 4 hrs, larvae L3    2 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    29 Caffeine 25 mg/ml 48 hrs, 4-day adult    16 Paraquat 5 mM 48 hrs, 4-day adult    27 Paraquat 10 mM 48 hrs, 4-day adult    20 Rotenone 2 μg 12 hrs, larvae L3    1 Rotenone 8 μg 12 hrs, larvae L3    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    12 cold shock, 4-day adult    8 heat shock, 4-day adult    19 Cadmium 50 mM 6 hrs, larvae L3    2 Cadmium 50 mM 12 hrs, larvae L3    3 Cadmium 50 mM 48 hrs, 4-day adult    13 Cadmium 100 mM 48 hrs, 4-day adult  32 Copper 0.5 mM 12 hrs, larvae L3    3 Copper 15 mM 48 hrs, 4-day adult  28 Zinc 5 mM 12 hrs, larvae L3    3 Zinc 4.5 mM 48 hrs, 4-day adult    9 Ethanol 2.5% 3 hrs, larvae L3  (37) Ethanol 5% 3 hrs, larvae L3    2 Ethanol 10% 3 hrs, larvae L3    2 Caffeine 1.5 mg/ml 4 hrs, larvae L3    2 Caffeine 2.5 mg/ml 48 hrs, 4-day adult  29 Caffeine 25 mg/ml 48 hrs, 4-day adult    16 Paraquat 5 mM 48 hrs, 4-day adult  27 Paraquat 10 mM 48 hrs, 4-day adult    20 Rotenone 2 μg 12 hrs, larvae L3    1 Rotenone 8 μg 12 hrs, larvae L3    1 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    12 cold shock, 4-day adult    8 heat shock, 4-day adult    19 Cadmium 50 mM 6 hrs, larvae L3    2 Cadmium 50 mM 12 hrs, larvae L3    3 Cadmium 50 mM 48 hrs, 4-day adult    13 Cadmium 100 mM 48 hrs, 4-day adult    32 Copper 0.5 mM 12 hrs, larvae L3    3 Copper 15 mM 48 hrs, 4-day adult    28 Zinc 5 mM 12 hrs, larvae L3    3 Zinc 4.5 mM 48 hrs, 4-day adult    9 Ethanol 2.5% 3 hrs, larvae L3    37 Ethanol 5% 3 hrs, larvae L3    2 Ethanol 10% 3 hrs, larvae L3    2 Caffeine 1.5 mg/ml 4 hrs, larvae L3    2 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    29 Caffeine 25 mg/ml 48 hrs, 4-day adult    16 Paraquat 5 mM 48 hrs, 4-day adult    27 Paraquat 10 mM 48 hrs, 4-day adult    20 Rotenone 2 μg 12 hrs, larvae L3    1 Rotenone 8 μg 12 hrs, larvae L3    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    12 cold shock, 4-day adult    8 heat shock, 4-day adult    19 Cadmium 50 mM 6 hrs, larvae L3    2 Cadmium 50 mM 12 hrs, larvae L3    3 Cadmium 50 mM 48 hrs, 4-day adult    13 Cadmium 100 mM 48 hrs, 4-day adult    32 Copper 0.5 mM 12 hrs, larvae L3    3 Copper 15 mM 48 hrs, 4-day adult    28 Zinc 5 mM 12 hrs, larvae L3    3 Zinc 4.5 mM 48 hrs, 4-day adult    9 Ethanol 2.5% 3 hrs, larvae L3    37 Ethanol 5% 3 hrs, larvae L3    2 Ethanol 10% 3 hrs, larvae L3    2 Caffeine 1.5 mg/ml 4 hrs, larvae L3    2 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    29 Caffeine 25 mg/ml 48 hrs, 4-day adult    16 Paraquat 5 mM 48 hrs, 4-day adult    27 Paraquat 10 mM 48 hrs, 4-day adult    20 Rotenone 2 μg 12 hrs, larvae L3    1 Rotenone 8 μg 12 hrs, larvae L3    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_13
External Data & Images
Linkouts	BDGP expression data • RE46053 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0003028 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG6824-RB FlyExpress - Embryonic expression images (BDGP data) • Show all FlyExpress processed images for ovo Stages(s) 1-3 Stages(s) 4-6 Stages(s) 7-8 Stages(s) 11-12 Stages(s) 13-16
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal, with Scer\GAL429BD ovoGS1144 lethal, with Scer\GAL4c355 ovoGS1144 lethal, with Scer\GAL4dpp.blk1 ovoGS1144 lethal, with Scer\GAL4hs.2sev ovoGS1144 lethal | embryonic stage ovosvb-3 lethal | embryonic stage | maternal effect ovoD3 lethal | embryonic stage | maternal effect | recessive ovo12-134 ovoM1 ovoM2 lethal | larval stage ovoD1rv5 lethal | polyphasic ovoD1rv1 ovoD1rv2 ovoD1rv3 ovoD1rv4 ovoD1rv6 ovoD1rv7 ovoD1rv8 ovoD1rv9 ovoD1rv10 ovoD1rv11 ovoD1rv12 ovoD1rv13 ovoD1rv14 ovoD1rv15 ovoD1rv17 ovoD1rv18 ovoD1rv19 ovoD1rv20 ovoD1rv21 ovosvb-1 ovosvb-2 ovosvb-3 lethal | polyphasic | recessive ovosvb-2 lethal | pupal stage, with Scer\GAL4pnr-MD237 ovoGD4166 lethal | recessive ovoe10G ovoe11A ovoPL107 viable ovoKG10083 ovosvb-108 viable, with Scer\GAL4pnr-MD237 ovoGD9026 Sterility Allele female fertile ovo5-1 ovo75-1 ovoct5 ovoct7 ovoct8 ovoct16 ovoct17 ovoct19 ovoct28 ovoct30 ovoct31 ovoct37 ovoct45 ovoct61 ovoct67 ovoct90 ovoD1R9 ovoD1R11 ovoD1R15 ovoD1r+ ovoD1ramber ovoD1Δzf ovoDf4 ovof2 ovof5-1 ovof28-3 ovof30-3 ovoR1 ovoR2 ovoR3 ovoR4 ovoX ovoY ovoyct ovoZ ovoΔa female sterile ovoD1-7 ovoD1 ovoD1rv29 ovoD2 ovoD3 ovoI ovoII ovoM2 ovoVI female sterile | dominant ovoD1-7 ovoD1-8 ovoD1-18 ovoD1 ovoD2 ovoD3 ovoD4 female sterile | heat sensitive ovoD1rv22 female sterile | recessive ovo12-134 ovoD1rSHD72 ovoD1rSHD81 ovoD1rSHD90 ovoD1rSHD91 ovoD1rSHD93 ovoD1rSHD101 ovoD1rv20 ovoD1rv22 ovoD1rv23 ovoD1rv24 ovoD1rv26 ovoD1rv27 ovoD1rv28 ovoD1rv29 ovoD1rv30 ovoD1rv31 ovoD1rv37 ovoD3rv53 ovoD3rv54 ovoD3rv55 ovoD3rv56 ovoe7E ovoe8F ovoe8K ovoM1 ovoM2 ovopB-GT1 fertile ovoKG10083 grandchildless ovoamk ovoΔa2 male fertile ovoD1rv23 ovoD2 Other Phenotypes Allele cytokinesis defective ovoD1r+ decreased cell growth ovoD1 feeding behavior defective | adult stage ovoD1 visible ovoPL107 visible, with Scer\GAL4bab1-GAL4-U ovoB2.Scer\UAS visible, with Scer\GAL4Bx-MS1096 ovoB2.Scer\UAS ovoD1.Scer\UAS.cAa ovosvb.Scer\UAS visible, with Scer\GAL4GMR.PF ovoB2.Scer\UAS ovoD1.Scer\UAS.cAa ovosvb.Scer\UAS visible, with Scer\GAL4pnr-MD237 ovoGD9026 visible | cold sensitive ovoD1rv22 visible | recessive | somatic clone ovoPL107 ovosvb-R9 visible | somatic clone ovosvb-1 ovosvb-R9 wild-type ovo2b.T:Hsap\MYC ovo+2b ovoamk ovoamv ovoD1r+ ovoOW10.0 ovoS-7.2 ovoT:Hsap\MYC ovoΔa2 ovoΔa ovoΔap Phenotype manifest in Allele adult abdomen & trichome | somatic clone ovosvb-R9 adult thorax & microchaeta, with Scer\GAL4Bx-MS1096 ovoD1.Scer\UAS.cAa adult thorax & microchaeta | somatic clone ovoPL107 ovosvb-1 ovosvb-R9 adult thorax & trichome, with Scer\GAL4Bx-MS1096 ovoB2.Scer\UAS ovoD1.Scer\UAS.cAa adult thorax & trichome | somatic clone ovosvb-R9 arista central core ovoPL107 arista lateral ovoPL107 cephalopharyngeal skeleton | maternal effect ovoD3 chaeta | supernumerary, with Scer\GAL4pnr-MD237 ovoGD9026 chorion ovoD2 ovoD3 ovoM2 denticle ovosvb-2 denticle, with Scer\GAL4e22c ovosvb.Scer\UAS denticle | ectopic ovosvb-2 denticle | ectopic, with Scer\GAL4en-e16E ovoScer\UAS.cPa denticle | ectopic, with Scer\GAL4ptc-559.1 ovoScer\UAS.cPa ovosvb.Scer\UAS denticle | ectopic, with Scer\GAL4ptc-559.1, ovo-2b.Scer\UAS ovosvb-1 denticle | ectopic, with Scer\GAL4ptc-559.1, ovo+2b.Scer\UAS ovosvb-1 denticle | ectopic, with Scer\GAL4ptc-559.1, ovosvb-1 ovo+2b.Scer\UAS ovo-2b.Scer\UAS denticle | ectopic, with Scer\GAL4wg.PM ovoScer\UAS.cPa denticle | supernumerary, with Scer\GAL4wg.PM ovosvb.Scer\UAS denticle belt ovosvb-1 ovosvb-2 ovounspecified denticle belt, with Scer\GAL4e22c ovoD1.Scer\UAS.cAa ovosvb.Scer\UAS denticle belt, with Scer\GAL4en-e16E ovoScer\UAS.cPa denticle belt, with Scer\GAL4ptc-559.1 ovoScer\UAS.cPa denticle belt, with Scer\GAL4wg.PM ovoScer\UAS.cPa ovoScer\UAS.A.T:Avic\GFP denticle belt | ectopic, with Scer\GAL4e22c ovoB2.Scer\UAS denticle belt | ectopic, with Scer\GAL4wg.PM ovoScer\UAS.B.T:Avic\GFP ovoScer\UAS.svb.T:Avic\GFP denticle belt | larval stage ovoD1rv20 ovoM1 denticle row 1, with Scer\GAL4en-e16E ovoD1.Scer\UAS denticle row 2, with Scer\GAL4ptc-559.1 ovoA.Scer\UAS ovoD1.Scer\UAS denticle row 3, with Scer\GAL4ptc-559.1 ovoA.Scer\UAS ovoD1.Scer\UAS dorsal appendage ovoD2 ovoD3 dorsal fine hair | temperature conditional ovosvb-108 egg ovoD1rv20 ovoD2 ovoD3 ovoM1 ovoM2 egg | maternal effect ovo12-134 ovoM1 ovoM2 egg chamber ovoD1 ovoD1rv1 ovoD1rv10 ovoD1rv11 ovoD1rv12 ovoD1rv13 ovoD1rv14 ovoD1rv15 ovoD1rv17 ovoD1rv18 ovoD1rv19 ovoD1rv2 ovoD1rv20 ovoD1rv21 ovoD1rv22 ovoD1rv23 ovoD1rv3 ovoD1rv4 ovoD1rv5 ovoD1rv6 ovoD1rv7 ovoD1rv8 ovoD1rv9 ovoD2 ovoM1 ovoe7E ovosvb-3 embryonic/first instar larval cuticle ovoPL107 ovosvb-1 ovounspecified embryonic/first instar larval cuticle, with Scer\GAL4e22c ovoB2.Scer\UAS ovoD1.Scer\UAS.cAa ovosvb.Scer\UAS embryonic/first instar larval cuticle, with Scer\GAL4ptc-559.1 ovosvb.Scer\UAS embryonic/first instar larval cuticle | maternal effect ovoD3 embryonic epidermis ovosvb-1 ovosvb-2 embryonic epidermis, with Scer\GAL4en-e16E ovoScer\UAS.cPa embryonic epidermis, with Scer\GAL4ptc-559.1 ovoScer\UAS.cPa embryonic epidermis, with Scer\GAL4wg.PM ovoScer\UAS.cPa embryonic epidermis | posterior compartment, with Scer\GAL4en-e16E ovoD1.Scer\UAS embryonic head | maternal effect ovoD3 embryonic segment | maternal effect ovoD3 eye, with Scer\GAL4GMR.PF ovoD1.Scer\UAS.cAa eye | cold sensitive ovoD1rv22 filamentous actin & embryonic/first instar larval cuticle | ectopic, with Scer\GAL4ptc-559.1 ovoScer\UAS.cPa filamentous actin & embryonic/first instar larval cuticle | ectopic | somatic clone, with Scer\GAL4Act5C.PI ovoScer\UAS.cPa germarium cap cell ovoD1rv23 germline cell ovoD1 ovoD1rv22 ovoD1rv23 ovounspecified germline cell | embryonic stage ovoD1rv22 ovoD1rv23 germline cell | female ovoD1 ovoD1-7 ovoD1-8 ovoD1rv23 ovoD1rv29 ovoD2 ovoD3 ovoD4 ovoI ovoII ovoVI germline cell | female, with Scer\GAL4nos.UTR.T:Hsim\VP16 ovoA.Scer\UAS germline cell | female | larval stage ovoD1rv22 interommatidial bristle, with Scer\GAL4GMR.PF ovoB2.Scer\UAS ovoD1.Scer\UAS.cAa ovosvb.Scer\UAS joint ovoPL107 joint, with Scer\GAL4bab1-GAL4-U ovoB2.Scer\UAS joint | somatic clone ovosvb-R9 leg ovoPL107 leg | somatic clone ovosvb-R9 mesothoracic tergum, with Scer\GAL4pnr-MD237 ovoGD9026 nurse cell ovoD1rv22 ovoD1rv23 nurse cell fusome ovoD1rv23 ommatidium, with Scer\GAL4GMR.PF ovoB2.Scer\UAS ovoD1.Scer\UAS.cAa ovosvb.Scer\UAS oocyte | oogenesis stage S2 ovoD1 oocyte | oogenesis stage S3 ovoD1 ovary ovoΔa2 ovoD1 ovoD1rv22 ovoD1rv23 ovoD1rv24 ovoD1rv26 ovoD1rv27 ovoD1rv28 ovoD1rv29 ovoD1rv30 ovoD1rv31 ovoD1rv37 ovoD2 ovoD3rv53 ovoD3rv54 ovoD3rv55 ovoD3rv56 ovoD4 ovopB-GT1 ovary, with Scer\GAL4nos.UTR.T:Hsim\VP16 ovoA.Scer\UAS ovary | adult stage ovoD1rv22 rhabdomere, with Scer\GAL4GMR.PF ovoB2.Scer\UAS sex comb ovosvb-1 spectrosome ovoD1rv23 stage S4 oocyte ovoD1 stage S6 oocyte ovoe7E sternopleural bristle | male ovosvb-1 tarsal segment, with Scer\GAL4bab1-GAL4-U ovoB2.Scer\UAS testis ovoΔa2 trichome | precursor | somatic clone, with Scer\GAL4αTub84B.PP ovoB2.Scer\UAS ovoD1.Scer\UAS.cAa wing hair, with Scer\GAL4Bx-MS1096 ovoB2.Scer\UAS ovoD1.Scer\UAS.cAa ovosvb.Scer\UAS
Classical Alleles ( 145 )
For All Classical Alleles Show
Allele of ovo Class Mutagen Stocks Known lesion ovoD1 antimorphic allele - genetic evidence ethyl methanesulfonate 4 Yes ovoD2 antimorphic allele - genetic evidence ethyl methanesulfonate 3 Yes ovoD1rv20 amorphic allele - genetic evidence, hypomorphic allele - genetic evidence gamma ray 1 -- ovoD1rv22 loss of function allele, amorphic allele - genetic evidence spontaneous gypsy element activity 1 Yes ovoD1rv23 loss of function allele, amorphic allele - genetic evidence spontaneous 1 Yes ovod02972 P-element activity 1 -- ovoD3 antimorphic allele - genetic evidence ethyl methanesulfonate 1 Yes ovof06126 piggyBac transposase 1 -- ovof07884 piggyBac transposase 1 -- ovoKG10083 P-element activity 1 -- ovoM1 loss of function allele, hypomorphic allele - genetic evidence ethyl methanesulfonate 1 -- ovoM2 loss of function allele, hypomorphic allele - genetic evidence ethyl methanesulfonate 1 -- ovoMI01236 1 -- ovoNP6126 1 -- ovosvb-2 ethyl methanesulfonate 1 -- ovoD1rv1 amorphic allele - genetic evidence ethyl methanesulfonate 0 -- ovoD1rv2 amorphic allele - genetic evidence ethyl methanesulfonate 0 -- ovoD1rv3 amorphic allele - genetic evidence ethyl methanesulfonate 0 -- ovoD1rv4 amorphic allele - genetic evidence ethyl methanesulfonate 0 -- ovoD1rv5 amorphic allele - genetic evidence ethyl methanesulfonate 0 -- ovoD1rv6 amorphic allele - genetic evidence ethyl methanesulfonate 0 -- ovo-4 X ray 0 Yes ovo12-134 ethyl methanesulfonate 0 -- ovo5-1 gypsy element activity 0 Yes ovo75-1 gypsy element activity 0 Yes ovoct16 gypsy element activity 0 Yes ovoct17 gypsy element activity 0 Yes ovoct19 gypsy element activity 0 Yes ovoct28 gypsy element activity 0 Yes ovoct30 gypsy element activity 0 Yes ovoct31 gypsy element activity 0 Yes ovoct37 gypsy element activity 0 Yes ovoct45 gypsy element activity 0 Yes ovoct5 gypsy element activity 0 Yes ovoct61 gypsy element activity 0 Yes ovoct67 gypsy element activity 0 Yes ovoct7 gypsy element activity 0 Yes ovoct8 gypsy element activity 0 Yes ovoct90 gypsy element activity 0 Yes ovoD1R10 gypsy element activity 0 Yes ovoD1R11 gypsy element activity 0 Yes ovoD1R12 gypsy element activity 0 Yes ovoD1R13 gypsy element activity 0 Yes ovoD1R14 gypsy element activity 0 Yes ovoD1R15 gypsy element activity 0 Yes ovoD1R1 gypsy element activity 0 Yes ovoD1R2 gypsy element activity 0 Yes ovoD1r38D Delta2-3 0 -- ovoD1R3 gypsy element activity 0 Yes ovoD1r47j Delta2-3 0 Yes ovoD1R4 gypsy element activity 0 Yes ovoD1R6 gypsy element activity 0 Yes ovoD1R7 gypsy element activity 0 Yes ovoD1R8 gypsy element activity 0 -- ovoD1R9 gypsy element activity 0 Yes ovoD1rOL Delta2-3 0 Yes ovoD1rP1 loss of function allele PM hybrid dysgenesis 0 Yes ovoD1rSHD101 loss of function allele PM hybrid dysgenesis 0 -- ovoD1rSHD72 loss of function allele PM hybrid dysgenesis 0 -- ovoD1rSHD81 loss of function allele PM hybrid dysgenesis 0 -- ovoD1rSHD90 loss of function allele spontaneous 0 Yes ovoD1rSHD91 loss of function allele spontaneous 0 Yes ovoD1rSHD93 loss of function allele spontaneous 0 Yes ovoD1rv10 gamma ray 0 -- ovoD1rv11 gamma ray 0 -- ovoD1rv12 gamma ray 0 -- ovoD1rv13 gamma ray 0 -- ovoD1rv14 gamma ray 0 -- ovoD1rv15 gamma ray 0 -- ovoD1rv16 gamma ray 0 -- ovoD1rv17 gamma ray 0 -- ovoD1rv18 gamma ray 0 -- ovoD1rv19 gamma ray 0 -- ovoD1rv21 gamma ray 0 -- ovoD1rv24 loss of function allele spontaneous 0 Yes ovoD1rv25 spontaneous 0 Yes ovoD1rv26 loss of function allele spontaneous 0 Yes ovoD1rv27 loss of function allele spontaneous 0 Yes ovoD1rv28 loss of function allele spontaneous 0 Yes ovoD1rv29 loss of function allele spontaneous 0 Yes ovoD1rv30 loss of function allele spontaneous 0 Yes ovoD1rv31 loss of function allele spontaneous 0 Yes ovoD1rv32 spontaneous 0 -- ovoD1rv33 spontaneous 0 -- ovoD1rv34 spontaneous 0 -- ovoD1rv35 spontaneous 0 -- ovoD1rv36 spontaneous 0 -- ovoD1rv37 loss of function allele spontaneous 0 Yes ovoD1rv38 PM hybrid dysgenesis 0 -- ovoD1rv39 PM hybrid dysgenesis 0 Yes ovoD1rv40 PM hybrid dysgenesis 0 Yes ovoD1rv41 PM hybrid dysgenesis 0 -- ovoD1rv42 PM hybrid dysgenesis 0 -- ovoD1rv43 PM hybrid dysgenesis 0 -- ovoD1rv44 PM hybrid dysgenesis 0 Yes ovoD1rv45 PM hybrid dysgenesis 0 -- ovoD1rv46 PM hybrid dysgenesis 0 -- ovoD1rv47 0 Yes ovoD1rv48 0 Yes ovoD1rv50 0 Yes ovoD1rv51 0 Yes ovoD1rv52 0 Yes ovoD1rv7 gamma ray 0 -- ovoD1rv8 gamma ray 0 -- ovoD1rv9 gamma ray 0 -- ovoD2rvBT2 spontaneous 0 -- ovoD3rv53 loss of function allele spontaneous 0 Yes ovoD3rv54 loss of function allele spontaneous 0 Yes ovoD3rv55 loss of function allele spontaneous 0 Yes ovoD3rv56 loss of function allele spontaneous 0 Yes ovoD3rv57 0 -- ovoDf4 gypsy element activity 0 Yes ovoe10G ethyl methanesulfonate 0 -- ovoe11A ethyl methanesulfonate 0 -- ovoe7E loss of function allele ethyl methanesulfonate 0 -- ovoe8F ethyl methanesulfonate 0 -- ovoe8K loss of function allele ethyl methanesulfonate 0 -- ovof04020 piggyBac transposase 0 -- ovof28-3 gypsy element activity 0 Yes ovof2 gypsy element activity 0 Yes ovof30-3 gypsy element activity 0 Yes ovof5-1 gypsy element activity 0 Yes ovoGS1144 Delta2-3 0 Yes ovoGS1153 0 Yes ovoGS1156 0 Yes ovoGS1160 0 Yes ovoGS1163 0 Yes ovoGS1164 0 Yes ovoGS31 0 Yes ovoGS42 0 Yes ovopB-GT1 piggyBac transposase 0 Yes ovoPL107 Delta2-3 0 Yes ovoR1 spontaneous 0 Yes ovoR2 spontaneous 0 Yes ovoR3 spontaneous 0 Yes ovoR4 spontaneous 0 Yes ovosvb-108 FLPase 0 Yes ovosvb-1 loss of function allele ethyl methanesulfonate 0 -- ovosvb-3 ethyl methanesulfonate 0 -- ovosvb-R9 P-element activity 0 Yes ovounspecified 0 -- ovoX gypsy element activity 0 Yes ovoY gypsy element activity 0 Yes ovoyct gypsy element activity 0 Yes ovoZ gypsy element activity 0 Yes
Alleles Carried on Transgenic Constructs ( 52 )
For All Alleles Carried on Transgenic Constructs Show
Allele of ovo Class Mutagen Stocks Known lesion ovoD1-18 in vitro construct 16 Yes ovoA.Scer\UAS in vitro construct - regulatory fusion 2 Yes ovoB.Scer\UAS.P\T in vitro construct - regulatory fusion 2 Yes ovoGD4166 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes ovoGD9026 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes ovoGL00335 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes ovoHMS02462 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes ovoT:Avic\GFP-SF,T:Zzzz\FLAG,T:Zzzz\PSP.CS,T:Zzzz\TEV.CS,T:Zzzz\BLRP in vitro construct - coding region fusion 1 Yes ovo+2b.Scer\UAS in vitro construct - regulatory fusion 0 Yes ovo+2b.T:Ecol\lacZ in vitro construct - coding region fusion 0 Yes ovo+2b in vitro construct 0 Yes ovo-2b.Scer\UAS in vitro construct - regulatory fusion 0 Yes ovo-2b.T:Ecol\lacZ in vitro construct - coding region fusion 0 Yes ovo-2b in vitro construct 0 Yes ovo2b.T:Hsap\MYC in vitro construct - coding region fusion 0 Yes ovoamk in vitro construct - site directed mutagenesis 0 Yes ovoamv in vitro construct - site directed mutagenesis 0 Yes ovoB.T:Ecol\lacZ in vitro construct - coding region fusion 0 Yes ovoB2.Scer\UAS in vitro construct - regulatory fusion 0 Yes ovoD1-7 in vitro construct - genomic fragment 0 Yes ovoD1-8 in vitro construct - regulatory fusion 0 Yes ovoD1.S23-1 in vitro construct 0 Yes ovoD1.Scer\UAS.cAa in vitro construct - site directed mutagenesis 0 Yes ovoD1.Scer\UAS in vitro construct - regulatory fusion in vitro construct 0 Yes ovoD1r+ in vitro construct - genomic fragment 0 Yes ovoD1ramber in vitro construct 0 Yes ovoD1Δzf in vitro construct 0 Yes ovoD4 gamma ray in vitro construct 0 Yes ovoI in vitro construct 0 Yes ovoII in vitro construct 0 Yes ovoIII in vitro construct 0 Yes ovoIV in vitro construct 0 Yes ovoM-D1.T:Ecol\lacZ in vitro construct - coding region fusion 0 Yes ovoM1.T:Ecol\lacZ in vitro construct - coding region fusion 0 Yes ovoM373.T:Ecol\lacZ in vitro construct - coding region fusion 0 Yes ovoNIG.6824R in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes ovoOW10.0 in vitro construct - genomic fragment 0 Yes ovoS-7.2 in vitro construct - genomic fragment 0 Yes ovoScer\UAS.A.T:Avic\GFP in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes ovoScer\UAS.B.T:Avic\GFP in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes ovoScer\UAS.cPa in vitro construct - regulatory fusion 0 Yes ovoScer\UAS.svb.T:Avic\GFP in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes ovostop2b.T:Ecol\lacZ in vitro construct - coding region fusion in vitro construct - site directed mutagenesis in vitro construct - amino acid replacement 0 Yes ovostop2b in vitro construct - site directed mutagenesis in vitro construct - amino acid replacement 0 Yes ovosvb.Scer\UAS in vitro construct - regulatory fusion 0 Yes ovoT:Hsap\MYC in vitro construct - coding region fusion 0 Yes ovoV in vitro construct 0 Yes ovoVI in vitro construct 0 Yes ovoZ.svb in vitro construct 0 Yes ovoΔa2 in vitro construct - deletion 0 Yes ovoΔa in vitro construct - deletion 0 Yes ovoΔap in vitro construct - deletion 0 Yes
Aneuploid Aberrations
Duplicated in	Dp(1;2)rb+71g (Eberl and Hilliker, 1988) Dp(1;2)w+64b (Eberl and Hilliker, 1988)
Disrupted in	Df(1)A113 (Harbecke and Lengyel, 1995) Df(1)bi-D2 (Oliver et al., 1988, Garfinkel et al., 1992, Mevel-Ninio et al., 1995) Df(1)bi-DL3 (Oliver et al., 1988) Df(1)bi-DL5 (Oliver et al., 1988) Df(1)cho19 (Steinmann-Zwicky, 1988) Df(1)EH587 (Eberl and Hilliker, 1988, Salz, 1992, Dick et al., 1996) Df(1)HC244 (Steinmann-Zwicky, 1988, Oliver et al., 1988, Salz, 1992) Df(1)HF366 (Wieschaus et al., 1984, Oliver et al., 1988) Df(1)JC70 (Oliver et al., 1988, Salz, 1992, Harbecke and Lengyel, 1995) Df(1)ovo4 (Steinmann-Zwicky, 1988) Df(1)ovo6 (Oliver et al., 1988, Salz, 1992, Garfinkel et al., 1992) Df(1)ovo7 (Oliver et al., 1988, Salz, 1992, Garfinkel et al., 1992) Df(1)ovo14 (Steinmann-Zwicky, 1988) Df(1)ovo15 (Steinmann-Zwicky, 1988) Df(1)ovo41 (Steinmann-Zwicky, 1988) Df(1)ovo44 (Steinmann-Zwicky, 1988, Salz, 1992) Df(1)rb14 (Steinmann-Zwicky, 1988) Df(1)rb30 (Oliver et al., 1988) Df(1)rb-71g (Oliver et al., 1987) Df(1)RC40 (Steinmann-Zwicky, 1988, Oliver et al., 1988, Salz, 1992) In(1)ovo5 (Oliver et al., 1988, Garfinkel et al., 1992)
Not disrupted in	Df(1)bi-D2 (Oliver et al., 1987, Mevel-Ninio et al., 1991) Df(1)C149 (Oliver et al., 1988) Df(1)cho23 (Steinmann-Zwicky, 1988) Df(1)DEB4D (Salz, 1992) Df(1)GA56 (Oliver et al., 1988) Df(1)GA102 (Oliver et al., 1988) Df(1)N73 (Oliver et al., 1988) Df(1)rb1 (Oliver et al., 1988) Df(1)rb13 (Steinmann-Zwicky, 1988, Oliver et al., 1988) Df(1)rb29 (Steinmann-Zwicky, 1988) Df(1)rb35 (Steinmann-Zwicky, 1988) Df(1)rb46 (Oliver et al., 1988) Df(1)rb47 (Oliver et al., 1988) Df(1)rb48 (Steinmann-Zwicky, 1988) Tp(1;2)rb+71g (Wieschaus et al., 1984) Tp(1;2)w+64b (Wieschaus et al., 1984)
Not duplicated in	Dp(1;2;Y)w+ (Eberl and Hilliker, 1988) Dp(1;2)sn+72d (Eberl and Hilliker, 1988)
Partially disrupted in	Df(1)svb108 (Frankel et al., 2010)
Transgenic Constructs & Insertions
Transgenic Constructs
reporter construct	Name Expression Data M{ovo-lacZ.DG1} No M{ovo-lacZ.DG2} No M{ovo-lacZ.DG3} No M{ovo-lacZ.DG4} No M{ovo-lacZ.DG5} No M{ovo-lacZ.DGO} No P{COW1.9} No P{COW2.1} No P{ovo.stop2b-lacZ} No P{ovo(-2b)-lacZ} No P{ovo(+2b)-lacZ} No P{ovo-lacZ.1.1} No P{ovo-lacZ.4} No P{ovo-lacZ.7.2} No P{ovo-lacZ.B.-71+59} No P{ovo-lacZ.B} No P{ovo-lacZ.C} No P{ovo-lacZ.D} No P{ovo-lacZ.distal} No P{ovo-lacZ.F} No P{ovo-lacZ.G} No P{ovo-lacZ.ID.D} No P{ovo-lacZ.K} No P{ovo-lacZ.M} No P{ovo-lacZ.medial} No P{ovo-lacZ.MV40} No P{ovo-lacZ.O} No P{ovo-lacZ.regionB} No P{ovo-lacZ.Z} No P{ovo-lacZ.Δap} No P{ovo-lacZ.ΔapΔ1} No P{ovo-lacZ.ΔapΔ2} No P{ovo-lacZ.ΔapΔ3} No P{ovo-lacZ.ΔapΔ4} No P{ovo-lacZ.ΔapΔ5} No P{ovo-lacZ.ΔapΔ6} No P{ovo-lacZ.ΔapΔ7} No P{ovo-lacZ.ΔapΔ8} No P{ovo-lacZ.Δbp} No P{ovo-lacZ.ΔbpΔ1} No P{ovo-lacZ.ΔbpΔ3} No P{ovo-lacZ.ΔbpΔ5} No P{ovo-lacZ.ΔbpΔ6} No P{ovo-lacZ.ΔbpΔ8} No P{ovo-lacZ.ΔbpΔ9} No P{ovoM1} No P{ovoM373} No P{ovoM-D1} No
UAS construct	Name Expression Data P{GD4166} NA P{GD9026} NA P{NIG.6824R} NA P{TRiP.GL00335} NA P{TRiP.HMS02462} NA P{UAS-ovo.-2b} NA P{UAS-ovo.+2b} NA P{UAS-ovo.A.GFP} NA P{UAS-ovo.A} NA P{UAS-ovo.B2} NA P{UAS-ovo.B.GFP} NA P{UAS-ovo.D1.A} NA P{UAS-ovo.D1} NA P{UAS-ovo.P} NA P{UAS-ovo.svb.GFP} NA P{UAS-ovo.svb} NA P{UASp-ovo.B} NA
GAL4 construct	Name Expression Data P{ovo-GAL4.proximal} No
characterization construct	Name Expression Data M{Z-ovo} NA P{COW0.0} NA P{ovo::Bole\ovo.ODM} NA P{ovo::Bole\ovo.ODP} NA P{ovo.myc-2b} NA P{ovo.myc-Cterm} NA P{ovo.S-7.2} NA P{ovo.stop2b} NA P{ovo(-2b)} NA P{ovo(+2b)} NA P{ovoamk} NA P{ovoamv} NA P{ovoD1.EN} NA P{ovoD1-7} NA P{ovoD1-8} NA P{ovoD1r+} NA P{ovoD1ramber} NA P{ovoD1Δzf} NA P{ovoD4} NA P{ovoEN} NA P{ovoΔa2} NA P{ovoΔa} NA P{ovoΔap} NA P{ovo-FLP.R} NA P{ovo-I} NA P{ovo-II} NA P{ovo-III} NA P{ovo-IV} NA P{ovo-V} NA P{ovo-VI} NA P{OW10.0} NA P{UAS-en::ovo.B2} NA P{UAS-en::ovo.D1} NA PBac{ovo:His2Av-YFP} NA PBac{ovo-GFP.FPTB} NA
Insertions
	Type of insertions Name Expression data miscellaneous insertions ?{}ovoD1r38D NA ?{}ovoD1r47j NA ?{}ovoD1rOL NA ?{}ovoD1rP1 NA copia{}ovoD1R1 NA copia{}ovoD1R2 NA copia{}ovoD1R3 NA copia{}ovoD1R6 NA copia{}ovoD1R10 NA copia{}ovoD1R12 NA copia{}ovoD1R13 NA copia{}ovoD1rSHD90 NA copia{}ovoD1rSHD91 NA copia{}ovoD1rSHD93 NA copia{}ovoD1rv44 NA copia{}ovoD3rv56 NA gypsy{}ovo5-1 NA gypsy{}ovo75-1 NA gypsy{}ovoct5 NA gypsy{}ovoct7 NA gypsy{}ovoct8 NA gypsy{}ovoct16 NA gypsy{}ovoct17 NA gypsy{}ovoct19 NA gypsy{}ovoct28 NA gypsy{}ovoct30 NA gypsy{}ovoct31 NA gypsy{}ovoct37 NA gypsy{}ovoct45 NA gypsy{}ovoct61 NA gypsy{}ovoct67 NA gypsy{}ovoct90 NA gypsy{}ovoD1R4 NA gypsy{}ovoD1R7 NA gypsy{}ovoD1R9 NA gypsy{}ovoD1R11 NA gypsy{}ovoD1R14 NA gypsy{}ovoD1R15 NA gypsy{}ovoD1rv22 NA gypsy{}ovoD1rv24 NA gypsy{}ovoD1rv25 NA gypsy{}ovoD1rv26 NA gypsy{}ovoD1rv27 NA gypsy{}ovoD1rv28 NA gypsy{}ovoD1rv29 NA gypsy{}ovoD1rv30 NA gypsy{}ovoD1rv31 NA gypsy{}ovoD1rv37 NA gypsy{}ovoD3rv53 NA gypsy{}ovoD3rv54 NA gypsy{}ovoD3rv55 NA gypsy{}ovoDf4 NA gypsy{}ovof2 NA gypsy{}ovof5-1 NA gypsy{}ovof28-3 NA gypsy{}ovof30-3 NA gypsy{}ovoR1 NA gypsy{}ovoR2 NA gypsy{}ovoR3 NA gypsy{}ovoR4 NA gypsy{}ovoX NA gypsy{}ovoY NA gypsy{}ovoycta NA gypsy{}ovoyctb NA gypsy{}ovoZ NA Mi{MIC}ovoMI01236 NA P{SUPor-P}KG00441 NA P{SUPor-P}ovoKG10083 NA PBac{GT1}ovopB-GT1 NA PBac{RB3.WH3}ovosvb-108 NA PBac{WH}ovof04020 NA PBac{WH}ovof06126 NA PBac{WH}ovof07884 NA Stalker2{}ovoD1rv23 NA insertion of mobile activating element P{GSV1}ovoGS31 NA P{GSV1}ovoGS42 NA P{GSV1}ovoGS1144 NA P{GSV1}ovoGS1153 NA P{GSV1}ovoGS1156 NA P{GSV1}ovoGS1160 NA P{GSV1}ovoGS1163 NA P{GSV1}ovoGS1164 NA P{Mae-UAS.6.11}GG01233GG01233 NA P{XP}ovod02972 NA insertion of enhancer trap P{lacW}ovoPL107 No insertion of enhancer trap binary system P{GawB}ovoNP6126 No
Gene Ontology: Function, Process & Cellular Component ( 19 unique terms )
Terms Based on Experimental Evidence ( 14 terms )
Molecular Function
CV term Evidence References
DNA binding inferred from direct assay (assigned by UniProtKB) (Lee and Garfinkel, 2000, Lu and Oliver, 2001) sequence-specific DNA binding inferred from direct assay (Chanut-Delalande et al., 2006)
Biological Process
CV term Evidence References
adult feeding behavior inferred from mutant phenotype (Wong et al., 2009) cuticle pattern formation inferred from mutant phenotype (Chanut-Delalande et al., 2006) cuticle pigmentation inferred from mutant phenotype (Chanut-Delalande et al., 2006) epidermal cell differentiation inferred from mutant phenotype (Chanut-Delalande et al., 2006) inferred from mutant phenotype (assigned by UniProtKB) (Payre et al., 1999) germ-line sex determination inferred from genetic interaction with UniProtKB:P19339 (assigned by UniProtKB) (Oliver et al., 1990) inferred from mutant phenotype (assigned by UniProtKB) (Oliver et al., 1990) imaginal disc-derived leg joint morphogenesis inferred from mutant phenotype (Pueyo and Couso, 2011) negative regulation of transcription from RNA polymerase II promoter inferred from mutant phenotype (Kondo et al., 2010) inferred from mutant phenotype (assigned by UniProtKB) (Andrews et al., 2000) non-sensory hair organization inferred from mutant phenotype (Delon et al., 2003) pheromone metabolic process inferred from mutant phenotype (Wicker and Jallon, 1995) positive regulation of transcription from RNA polymerase II promoter inferred from mutant phenotype (Kondo et al., 2010, Fernandes et al., 2010) inferred from mutant phenotype (assigned by UniProtKB) (Andrews et al., 2000) positive regulation of transposon integration inferred from mutant phenotype (Labrador et al., 2008)
Cellular Component
CV term Evidence References
nucleus inferred from direct assay (Kondo et al., 2010)
Terms Based on Predictions or Assertions ( 8 terms )
Molecular Function
CV term Evidence References
DNA binding traceable author statement (Delon and Payre, 2004) zinc ion binding inferred from electronic annotation with InterPro:IPR007087, InterPro:IPR015880 (FlyBase Curators et al., 2004-)
Biological Process
CV term Evidence References
cuticle development traceable author statement (Sanson, 2001) female germ-line sex determination non-traceable author statement (Williamson and Lehmann, 1996, Swiss-Prot Project Members, 1996.10.1) non-sensory hair organization traceable author statement (Delon and Payre, 2004) oogenesis traceable author statement (Perrimon et al., 1986, Mahowald, 2001) regulation of transcription, DNA-dependent traceable author statement (Gonzalez-Gaitan, 2003)
Cellular Component
CV term Evidence References
nucleus inferred by curator from GO:0003677 (assigned by UniProtKB) (Lee and Garfinkel, 2000) inferred from sequence or structural similarity with UniProtKB:Q60821 (FlyBase, 1992-) non-traceable author statement (Swiss-Prot Project Members, 1996.10.1)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
protein-protein
Interacting group Assay References
ovo - ATPsyn-γ anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) ovo - CG7033 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) ovo - CG8545 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) ovo - Hsc70-1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) ovo - Hsp27 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) ovo - Hsp68 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) ovo - Hsp70Aa anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) ovo - Mlf anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) ovo - P32 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) ovo - Pgi anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) ovo - SdhB anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) ovo - Vha55 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) ovo - isoQC anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) ovo - mRpL52 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) ovo - mts anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) ovo - yki anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) ovo - α-Spec anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23)
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions ovo allele Gene References ovoD1.Scer\UAS pan (Payre et al., 1999) Ras85D (Payre et al., 1999) ovoD1rv22 mle (Oliver et al., 1993, Oliver and Pauli, 1998) ovoD1rv23 mle (Oliver et al., 1993, Oliver and Pauli, 1998) otu (Hinson et al., 1999) ovoD2 snf (Pauli et al., 1995) ovoe7E Sxl (Oliver and Pauli, 1998) ovoe8F otu (Hinson et al., 1999) ovoe8K Sxl (Oliver and Pauli, 1998) ovoM1 otu (Hinson et al., 1999) ovoM2 otu (Hinson et al., 1999) Sxl (Oliver and Pauli, 1998) ovoScer\UAS.cPa arm (Payre et al., 1999) Egfr (Payre et al., 1999) ovosvb-2 pan (Payre et al., 1999) spi (Payre et al., 1999) wg (Payre et al., 1999) unspecified Nsf2 (Laviolette et al., 2005) pbl (Gregory et al., 2007)
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 57942 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0003028 DroID - A comprehensive database of gene and protein interactions. • FBgn0003028 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 31429
Orthologs
OrthoDB Orthologs (47) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG66HGWZ Dipteran inclusive ortholog search EOG67WNXP Insect inclusive ortholog search EOG60ZPTN Arthropod inclusive ortholog search EOG66DJJS Metazoa inclusive ortholog search EOG6MWN21
Orthologs in Drosophila Species (EOG66HGWZ)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\ovo     Drosophila simulans   Dsim\GD24377 Y   Drosophila sechellia   Dsec\GM12381 Y   Drosophila erecta   Dere\GG18741 Y   Drosophila yakuba   Dyak\GE16381 Y   Drosophila ananassae   Dana\GF20355 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA22634 Y   Drosophila persimilis   Dper\GL26817 Y   Drosophila willistoni   Dwil\GK10250 Y   Drosophila virilis   Dvir\ovo Y   Drosophila mojavensis   Dmoj\GI21666 Y   Drosophila grimshawi   Dgri\GH24684 Y
Orthologs in non-Drosophila Dipterans (EOG67WNXP)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL017521   Anopheles gambiae Malaria mosquito  Agam\AGAP000114   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ018505
Orthologs in non-Dipteran Insects (EOG60ZPTN)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\GB51354   Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG009257   Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH14895   Atta cephalotes Leafcutter ant  Acep\ACEP17857   Camponotus floridanus Florida carpenter ant  Cflo\CFLO24957   Linepithema humile Argentine ant  Lhum\LH14472   Pogonomyrmex barbatus Red harvester ant  Pbar\PB12501   Solenopsis invicta Red fire ant  Sinv\SINV17081   Acyrthosiphon pisum Pea aphid  Apim\ACYPI003064   Bombyx mori Silkmoth  Bmor\BGIBMGA000988   Pediculus humanus Human body louse  Phum\PHUM086430   Tribolium castaneum Red flour beetle  Tcas\GLEAN_08099
Orthologs in non-Insect Arthropods (EOG66DJJS)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\slmA1   Ixodes scapularis Deer tick  Isca\ISCW013547
Orthologs in non-Arthropod Metazoa (EOG6MWN21)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Caenorhabditis elegans Nematode  Cele\lin-48   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_012448gn   Danio rerio Zebrafish  Drer\zgc:171929   Danio rerio Zebrafish  Drer\ovol1   Danio rerio Zebrafish  Drer\si:dkey-17e16.13   Xenopus tropicalis Western clawed frog  Xtro\ovol1   Xenopus tropicalis Western clawed frog  Xtro\ovol2   Xenopus tropicalis Western clawed frog  Xtro\ENSXETG00000030032   Gallus gallus Domestic chicken  Ggal\OVOL2   Mus musculus House mouse  Mmus\Ovol1   Mus musculus House mouse  Mmus\Ovol3   Mus musculus House mouse  Mmus\Ovol2   Rattus norvegicus Norway rat  Rnor\ENSRNOG00000024880   Rattus norvegicus Norway rat  Rnor\Ovol1   Rattus norvegicus Norway rat  Rnor\Ovol2   Homo sapiens Human  Hsap\OVOL1   Homo sapiens Human  Hsap\OVOL2   Homo sapiens Human  Hsap\ENSG00000105261
Human Orthologs (3)
Gene OMIM HGNC Hsap\OVOL1     Hsap\OVOL2     Hsap\ENSG00000105261
AAA Orthologs (11) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD24377 Drosophila sechellia Dsec\GM12381 Drosophila erecta Dere\GG18741 Drosophila yakuba Dyak\GE16381 Drosophila ananassae Dana\GF20355 Drosophila pseudoobscura pseudoobscura Dpse\GA22634 Drosophila persimilis Dper\GL26817 Drosophila willistoni Dwil\GK10250 Drosophila virilis Dvir\ovo Drosophila mojavensis Dmoj\GI21666 Drosophila grimshawi Dgri\GH24684
Stocks & Reagents
Stocks Listed in FlyBase ( 46 )
Bloomington	38427 w*; P{UAS-ovo.A}AM 38428 w*; P{UAS-ovo.A}1M 38429 w*; P{UASp-ovo.B}Cmm 38430 w*; P{UASp-ovo.B}GF2 4620 y1 ovoM2/FM7c 816 w1 ovosvb-2/FM7c
Harvard	- P{XP}ovod02972 - PBac{WH}ovof06126 - PBac{WH}ovof07884
VDRC	v12664 w1118 P{GD4166}v12664 v12663 w1118; P{GD4166}v12663 v41584 w1118; P{GD9026}v41584
	More stocks available...
Genomic Clones ( 3 )
	BACR15B10 BACR29B16 BACR32C01 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 76 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	LD47350 RE46053
Other clones	DPiM_RE46053
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	GM03519 GM08493 GM13839 GM18612 GM21972 GM25346 GM28650 LD19169 LD22623 LD24569 RE16509 RE40331 RE60822
Other clones	20673 28694 62889 77718 103830 106182 160092 162127 173495 183304 184175 190850 214275.51 214473.48 CK01.35D.D8 CK01.36A.A6 CK01.85C.H9 CK01.95A.D3 CK01.129C.G12 Dmel_dig_007158_0698_0556 Dmel_dig_018085_0608_2360 Dmel_neb_000831_0884_3724 Dmel_neb_013316_0584_0734 EK030545 EK030727 EK067631 EK073911 EK095860 EK136132 EK165208 EK166358 EK188550 EK198108 EK207602 EK233909 EK244254 EK262939 EK265641 EK288017 EK289133 EK293146 EP08814 EP21353 FGC028B03 FGM220F10 GM14246 LD09657 RP004145301 RP004218669 RP004222257 RP004225426 RP004230643 RP004230661 RP004233348 RP004238607 RP004243209 RP004403584 RP004456938 RP004485159 RP004509598
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0003028 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 31429
Antibody Information
	polyclonal (Kondo et al., 2010)
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: ovo CG6824 (Zhao, 1999.11)
Source for database merge of	Source for merge of: ovo CG15467 (FlyBase Genome Annotators, 2002-2003)
Additional comments	Annotations CG6824 and CG15467 merged as CG6824 (which corresponds to ovo) in release 3 of the genome annotation. (FlyBase Genome Annotators, 2002-2003) Recessive alleles, mostly recovered as revertants of dominant alleles, usually but not always, simultaneously mutant lzl; The lzl eye phenotype is cold-sensitive and semidominant. Most revertants are amorphic in that, when tested in heterozygous combination with ovoD1rv22 or ovoD1rv23, they have atrophic ovaries, with no egg chambers observable.
Other Comments
	Expression is enriched in embryonic gonads. (Shigenobu et al., 2006) ovo is necessary and sufficient for cells to grow F-actin based extensions. (Delon et al., 2003) The ovo-A and ovo-B isoforms have opposite regulatory activities. (Andrews et al., 2000) ovo-B function is required during oogenesis, while ovo-A is important for subsequent embryonic germline development. (Andrews et al., 2000) ovo is required for the differentiation of XX germ cells during larval gonial stages. ovo may also have a role in other oogenic functions. (Hinson et al., 1999) Transcriptional regulation of ovo integrates inputs from the wg and Egfr pathways and control epidermis differentiation. (Payre et al., 1999) ovo is a key selector gene that, cell autonomously, directs cytoskeletal modifications producing the denticle. (Payre et al., 1999) Analysis of dominant-negative ovoD mutations suggests that the dominant activity is due to the new initiation codons in the ovo-B isoform mRNAs and not due to the amino acid substitutions in the ovo-A isoform. (Andrews et al., 1998) ovo protein regulates its own and the otu promoters. (Lu et al., 1998) Absence of ovo+ in females and extra copies of ovo+ in males do not result in reciprocal phenotypes. (Oliver and Pauli, 1998) High ovo+ copy number is not sufficient for overt development of XY germ cells. The absence of ovo+ in XX germ cells results in altered sex determination and cell viability, but increased ovo+ activity in XY germ cells is insufficient to impair germline viability and is probably insufficient to alter sexual identity. (Oliver and Pauli, 1998) A method that allows the efficient recovery of female germline mosaics for mutations localised n the autosomes has been developed using P{ovoD1-18} P{FRT(whs)} P{hsFLP}. (Chou and Perrimon, 1996, Perrimon et al., 1996) The dominant-negative effects of the ovoD mutations are likely to arise from the expression of novel protein isoforms, starting during germline cell differentiation. (Mevel-Ninio et al., 1996) Female germ cells require zygotic ovo function for survival mainly during the second larval, third larval and pupal stages. (Staab and Steinmann-Zwicky, 1996) Mapping of gypsy insertions into the ovo gene reveals a global insertion specificity rather than a specificity for a local nucleotide consensus sequence. (Dej et al., 1995) Nurse cell-specific genes are functional in the pseudonurse cells of otu mutants, but the transport of pum, otu, ovo and bcd RNAs to the cytoplasm is affected. (Heino et al., 1995) The structure and expression of the complex ovo locus is characterised; differential embryonic expression of ovo and svb transcripts suggests the existance of several isoform ovo protein products. (Mevel-Ninio et al., 1995) otu and ovo are required cell autonomously in the female germline for germ cell proliferation and differentiation. XY germ cells do not require otu when developing in testes, but become dependent on otu function for proliferation when placed in an ovary. The requirement for ovo is dependent on a cell autonomous signal derived from the X:A ratio. The differential regulation of the otu and ovo genes provides a mechanism for the female germline to incorporate both somatic and cell-autonomous inputs required for oogenesis. (Nagoshi et al., 1995) 300 deficiency chromosomes have been screened for enhancers and suppressors of the ovo mutant phenotype. More than a dozen small regions probably contain genes whose products act in developmental hierarchies that include ovo+ protein. (Pauli et al., 1995) Zygotic ovo activity is not essential for pole cell viability or proliferation during stages of embryogenesis. Pupal gonads fail to produce egg chambers indicating that the agametic adult phenotype is caused by a block in oogenesis before cyst formation, rather than the degeneration of existing egg chambers. ovo function is not essential for germline viability before pupariation. (Rodesch et al., 1995) ovo, otu, snf and Sxl are not involved in the early events of germline sex determination, but are required later, during metamorphosis or in the adult for oogenesis. (Staab and Steinmann-Zwicky, 1995) Alternative splicing generates two types of transcripts from the ovo gene. (Garfinkel et al., 1994) An insertion of a transgene containing the ovoD1 mutation onto an autosome can confer a dominant female sterile phenotype. (Mevel-Ninio et al., 1994) High level of ovo+ expression depends on the number of X chromosomes, not the somatic sexual signals. The ovo+ gene products are required for events occurring only in flies with two X chromosomes. (Oliver et al., 1994) The genetic hierarchy regulating female germ-line sex determination includes tra, tra2, dsx, fu, otu, ovo, snf and Sxl. otu+, ovo+ and snf+ activities are required for female-specific Sxl+ pre-mRNA splicing within 2X germ-line cells. (Oliver et al., 1993) Gene dosage studies demonstrate additional interaction of with mutations at otu with the ovo locus. (Pauli et al., 1993) Phenotypic analysis of mutations suggests that ovo encodes a function necessary for normal development of the oocyte. (Mevel-Ninio et al., 1991) ovo appears to be involved in germ line sex determination and is linked in some manner to sex determination in the soma. (Oliver et al., 1990) Molecular analysis of ovo revertants from a cross with the y v f mal strain demonstrate they have acquired either a gypsy or copia insertion at cytological location 4E. (Mevel-Ninio et al., 1989) Homozygous females and females of the genotype Df(1)HC244, SxlM1/ovo are sterile with ovaries devoid of germ cells: ovo must act downstream of Sxl or in a different pathway. (Steinmann-Zwicky, 1988) ovo is required for early female germ line maintenance but is not required for male germ line stability. (Oliver et al., 1987) ovo mutants display short denticles that are reduced in number and an absence of dorsal hairs. (Wieschaus et al., 1984) The expression of genes controlling neurogenesis is dependent on the previous activity of the genes controlling the development of the embryonic dorsal-ventral pattern. (Campos-Ortega, 1983) All ovo alleles fully penetrant for female sterility; no male function for ovo+ known. Lack of zygotic activity results in complete absence of germ-line cells in adult female; reduction in numbers of germ cells first evident during early gastrulation. Homozygotes for weaker alleles produce germ cells, but oogenesis defective; egg chambers may degenerate prior to vitellogenesis or proceed through oogenesis and be oviposited, depending on allele; laid eggs are permeable to neutral red and never develop. Heterozygotes for two of the dominant alleles phenotypically similar to homozygotes for weak recessive alleles. Ovarian tumors formed in females carrying ovoD3 in heterozygous combination with the hypomorphic alleles, e.g., ovoD1rv20, or with snf. The ovoD2 mutation is partially suppressed by many Sxl alleles. ovoD1/+ females produce no eggs; extensively utilized in the selection of ovo+ germ-line clones. svb alleles are homozygous lethal. Many fewer denticles than wild type; remaining denticles small and with characteristic morphology. Denticles arranged in belts in the abdominal segments; absent from thoracic segments. Cell autonomous in mosaics; useful in studying embryonic mosaics.
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_080338 NM_167026 NM_167027 NM_001038742 NM_001169202 RefSeq (Proteins) • NP_525077 NP_726971 NP_726972 NP_001033831 NP_001162673 DDBJ / EMBL / GenBank • AAB50918 AAB50919 AAB60216 AAF46001 AAF46001.2 AAF46002 AAF46002.2 AAF46003 AAF46003.2 AAM11191 AAM50303 ABC67174 ACZ95210 AI515494 AJ430588 AJ430589 AW943894 AY094838 AY119649 BI361721 CAB34880 CAB36921 CAD23206 CAD23207 CL528277 CZ473105 CZ486607 CZ488775 CZ488776 CZ490632 S83520 U10670 U10671 U11383 X59772 Z83574 Entrez Gene - A searchable database of RefSeq genes. • 31429 UniProtKB/Swiss-Prot • P51521 UniProtKB/TrEMBL • E1JJE5
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Zinc finger, C2H2-like (IPR015880) Zinc finger, C2H2 (IPR007087) Zinc finger C2H2-type/integrase DNA-binding domain (IPR013087) BDGP expression data - Patterns of gene expression in Drosophila embryogenesis • RE46053
Linkouts
	BioGRID - A database of protein and genetic interactions • 57942 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0003028 DroID - A comprehensive database of gene and protein interactions. • FBgn0003028 DRSC - Results from RNAi screens. • FBgn0003028 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0003028 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG6824-RB FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0003028 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 31429 Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution • /dbzhnsky/ovo1.htm InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 31429 modMine - Data generated by the modENCODE project. • FBgn0003028 REDfly - A database of transcriptional regulatory elements. • FBgn0003028
Synonyms & Secondary IDs ( 23 )
Reported As
Symbol Synonym	CG6824 (Bourbon et al., 2002, Laviolette et al., 2005, Alekseyenko et al., 2006, Grieder et al., 2007, Ni et al., 2011.7.19, Ni et al., 2010.12.1) CG15467 (Ringrose et al., 2003, Luschnig, 2003.12.17, ) Fs(1)K155   Fs(1)K1103 (Kerridge and Dura, 1982, ) fs(1)K1237 (Perrimon et al., 1986) Fs(1)K1237   fs(1)M1 (Mohler, 1977) fs(1)M38 (Mohler, 1977) OVO (Abou-Zied et al., 2002, Lu and Oliver, 2000) Ovo (Perrimon et al., 1986) ovo (Casper and Doren, 2007, Laviolette et al., 2005, Alekseyenko et al., 2006, Gregory et al., 2007, Shigenobu et al., 2006, Shapiro and Anderson, 2006, Metzstein, 2007.7.24, Aerts et al., 2007, McGregor et al., 2007, Song et al., 2007, Casper and Van Doren, 2006, Abou-Zied et al., 2008, Grieder et al., 2007, Beaucher et al., 2007, Haerty et al., 2007, Overton et al., 2007, Lukacsovich et al., 2008, Wang and Riechmann, 2007, Labrador et al., 2008, Wong et al., 2009, Barnes et al., 2007, Tricoire et al., 2009, Casper and Van Doren, 2009, Popodi et al., 2010-, Kondo et al., 2010, Jung et al., 2010, Cognigni et al., 2011, Yatsu et al., 2008, Graveley et al., 2011, Vazquez-Pianzola et al., 2011, Japanese National Institute of Genetics, 2012.5.21, Spokony and White, 2012.11.14) ovo/shavenbaby (Simpson, 2002) ovo/svb (Delon et al., 2003, Martinez Arias, 2003, Simpson, 2002, Sucena, 2002, Payre et al., 1999) Ovo-D (Blair, 2003) ovoD (Lujan et al., 2008, Ribeiro and Dickson, 2010) Shv (Andrew and Baker, 2008) svb (Laugier et al., 2005, Delon and Payre, 2004, Gonzalez-Gaitan, 2003, Sucena et al., 2003, Bourbon et al., 2002, Angelats et al., 2002, Delon et al., 2001, Delon et al., 2001, Tanaka et al., 2000, Schock et al., 2000, Garfinkel, 1994.6.10, Delon, 2002.2.12, Bejsovec, 1999, Payre et al., 1999, Morize et al., 1998, Garfinkel et al., 1997, Rulifson et al., 1996, Harbecke and Lengyel, 1995, Wolfner and Goldberg, 1994, Grinblat et al., 1994, Martinez Arias, 1993, Garfinkel et al., 1992, Perrimon et al., 1989, Oliver et al., 1988, Hoppe and Greenspan, 1986, Gergen and Wieschaus, 1985, Wieschaus et al., 1984, Chanut-Delalande et al., 2006, Payre et al., 2007, Galindo et al., 2007, Frankel et al., 2010, McGregor et al., 2007, Payre et al., 2008, Buescher and Chia, 2008, Payre et al., 2008, Overton et al., 2007, Coiffier et al., 2008, Kondo et al., 2007, Andrew and Baker, 2008, Fernandes et al., 2010, Kondo et al., 2010, Frankel et al., 2010, Bejsovec and Chao, 2012, Pueyo and Couso, 2011) Svb (Hatini and DiNardo, 2001, Kodjabachian, 1999, Payre et al., 2007, Robinson, 2006, Aerts et al., 2010) Svb/Ovo (Walters et al., 2006)
Name Synonym	ovo (Barnes et al., 2007) ovo/shaven-baby (Goodman and Coughlin, 2000, Sucena and Stern, 2000, Martinez Arias, 2003) shaven baby (Overton et al., 2005, Gibson and Palsson, 2001, Hoppe and Greenspan, 1986, Kondo et al., 2007, Coiffier et al., 2008) Shavenbaby (Gonzalez-Gaitan, 2003, Peifer, 1999, Payre et al., 2007, Payre et al., 2007, Payre et al., 2007, Plaza et al., 2007, Robinson, 2006, Payre et al., 2008, Buescher and Chia, 2008) shavenbaby (Saller et al., 2002, Delon and Payre, 2004, Chanut-Delalande et al., 2006, Dilks and DiNardo, 2007, Payre et al., 2008, Andrew and Baker, 2008, Overton et al., 2007, Kondo et al., 2007, Fernandes et al., 2010, Kondo et al., 2010)
Secondary FlyBase IDs
	FBgn0000825 FBgn0000849 FBgn0003650 FBgn0029741
References ( 290 )
Generate a list of	All references relating to this gene ( 290 )
List References by type	Research paper  ( 150 ) Supplementary material  ( 5 ) Review  ( 42 ) Personal communication to FlyBase  ( 16 ) Abstract  ( 63 ) FlyBase analysis  ( 3 ) DNA/RNA sequence record  ( 2 ) Stock list  ( 1 ) Curated genome annotation  ( 4 ) Protein sequence record  ( 1 ) Website  ( 1 ) Book  ( 1 )
Recent research papers ( 8 )
	Bejsovec and Chao, 2012, Development 139(4): 690--698 crinkled reveals a new role for Wingless signaling in Drosophila denticle formation. [FBrf0217282] Frankel et al., 2012, Proc. Natl. Acad. Sci. U.S.A. 109(51): 20975--20979 Conserved regulatory architecture underlies parallel genetic changes and convergent phenotypic evolution. [FBrf0220360] Krauchunas et al., 2012, Dev. Biol. 370(1): 125--134 Protein phosphorylation changes reveal new candidates in the regulation of egg activation and early embryogenesis in D. melanogaster. [FBrf0219342] Cognigni et al., 2011, Cell Metab. 13(1): 92--104 Enteric neurons and systemic signals couple nutritional and reproductive status with intestinal homeostasis. [FBrf0212594] Frankel et al., 2011, Nature 474(7353): 598--603 Morphological evolution caused by many subtle-effect substitutions in regulatory DNA. [FBrf0214052] Graveley et al., 2011, Nature 471(7339): 473--479 The developmental transcriptome of Drosophila melanogaster. [FBrf0213330] Pueyo and Couso, 2011, Dev. Biol. 355(2): 183--193 Tarsal-less peptides control Notch signalling through the Shavenbaby transcription factor. [FBrf0213970] Vazquez-Pianzola et al., 2011, Dev. Biol. 357(2): 404--418 Pabp binds to the osk 3'UTR and specifically contributes to osk mRNA stability and oocyte accumulation. [FBrf0214798] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2011 Show reviews ...