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Gene Dmel\pcx

General Information
Symbol	Dmel\pcx	Species	D. melanogaster
Name	pecanex	Annotation symbol	CG3443
Feature type	protein_coding_gene	FlyBase ID	FBgn0003048
Gene Model Status	Current	Stock availability	10 publicly available
Also Known As	EG:30B8.4, fs(1)pcx, fs(1)M10
Genomic Location
Chromosome (arm)	X	Recombination map	1-0.9
Cytogenetic map	2F1-2F1	Sequence location	X:2,119,744..2,132,089 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene pecanex is referred to in FlyBase by the symbol Dmel\pcx (CG3443, FBgn0003048). It is a protein_coding_gene from Drosophila melanogaster. Its molecular function is unknown. There is experimental evidence that it is involved in the biological process: lateral inhibition. 22 alleles are reported. The phenotype of these alleles is annotated with: presumptive embryonic/larval central nervous system. It has one annotated transcript and one annotated polypeptide. Protein features are: Pecanex. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of low expression. Peak expression observed within 00-06 hour embryonic stages. Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: larval/adult central nervous system, larval Malpighian tubules, larval salivary gland, larval trachea, adult ovary. Comments on Affy2 ProbeSet: ProbeSet 1638200_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of pcx. Gene sequence location is X:2119744..2132089.
Phenotypic Description from the Red Book (Lindsley & Zimm 1992)
Gene/Allele symbols may differ from current usage	fs(1)A387 Embryos fail late in development; some rescue by fertilization with sperm carrying normal allele. pcx: pecanex Maternal-effect-lethal mutation; homozygous mutant females crossed to mutant males produce lethal embryos showing hypertrophy of the central nervous system at the expense of the epidermis, a small patch of dorsal cuticle remaining but no ventral cuticle. This embryonic phenotype (as well as the reduced eye phenotype of viable pcx adults) resembles that of amx. Homozygous pcx lethal embryos can be rescued genetically; some mutant females (but not pcx1 homozygotes) crossed to wild-type males produce viable adult pcx/+ female offspring (Romans et al., 1976; Perrimon et al., 1984); the pcx/Y male offspring are lethal. pcx/+ heterozygous females, which are fertile, crossed to viable pcx/Y males (also fertile) produce viable adult males (pcx/Y and +/Y) and viable adult females (pcx/pcx and pcx/+) (Romans et al., 1976). Homozygous pcx lethal embryos can be partially rescued almost up to hatching by preblastoderm microinjection of wild-type or amx ooplasm (La Bonne and Mahowald, 1985a). Germ line clonal analysis demonstrates the germ-line dependency of the pcx embryonic lethal phenotype (Perrimon et al., 1984).
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2012_01	Sequence features HFA18190 HFA18187 BKN20058 HFA18816 HFA18188 HFA18189 HFA18186
FB2011_10
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 2F1-2F1   Limits computationally determined from genome sequence between P{EP}EP1460&P{EP}CG2924EP1596 and P{EP}EP1606
Experimentally Determined Cytological Location
Cytogenetic map Notes References 2E-2F   (determined by in situ hybridisation)   (LaBonne et al., 1989)
Experimentally Determined Recombination Data
Location	1-0.9   1- (Mohler, 1977)
Left of (cM)	cv (Mohler, 1977)
Right of (cM)	y (Mohler, 1977)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\pcx for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	DGC clone SD01552 appears problematic: incomplete CDS
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) pcx-RB FBtr0070395  NM_080306   11763   3433
Additional Transcript Data & Comments
Reported size (kB)	9, 3.7, 2.3 (northern blot) (LaBonne et al., 1989)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein pcx-PB   FBpp0070379   367.6   3433   6.01     NP_525045   AAF45756
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments	2483 aa fragment marked as 5' end in GenBank contains all of M25662 (FlyBase, 1992-) 1938 aa fragment contained within M74329 (FlyBase, 1992-) No significant similarity was found between the pcx protein sequence and any other protein. (LaBonne et al., 1989)
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Pecanex (IPR007735)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA264713   AA695247   AA949143   AE014298 AAF45756   AI294653   AI533138   AL009171 CAA15652   AL009195 CAA15708   AW944187   AY058752 AAL13981   BF486303   BF487794   BF498645   BF500716   BF504950   BG636992   BG639497   BI641479   CO155230   CO156717   CO183948   CO186712   CO285713   CO329267   EC068892   EC069952   EC090176   EC208279   EC250497   EC263851   EC264021   FL502734   FL502779   FL502870   FL502908   GR705867   M25662 AAA28749   M74329 AAA28747   Z32056
UniProtKB/Swiss-Prot	P18490
UniProtKB/TrEMBL
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0003048    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0003048 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of low expression. Peak expression observed within 00-06 hour embryonic stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0003048 expression level Developmental Stage   Expression Level embryo 00-02hr    1347 embryo 02-04hr    1098 embryo 04-06hr    1626 embryo 06-08hr    1300 embryo 08-10hr    1083 embryo 10-12hr    569 embryo 12-14hr    782 embryo 14-16hr    724 embryo 16-18hr    500 embryo 18-20hr    374 embryo 20-22hr    269 embryo 22-24hr    260 larva L1    337 larva L2    281 larva L3 12hr old    255 larva L3 puffstage 1-2    244 larva L3 puffstage 3-6    697 larva L3 puffstage 7-9    978 white prepupae new    1262 white prepupae 12hr    793 white prepupae 24hr    813 pupae 2d postWPP    615 pupae 3d postWPP    311 pupae 4d postWPP    357 adult male 01day    443 adult male 05day    411 adult male 30day    423 adult female 01day    795 adult female 05day    1057 adult female 30day    1085 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (1347) embryo 02-04hr  (1098) embryo 04-06hr  (1626) embryo 06-08hr  (1300) embryo 08-10hr  (1083) embryo 10-12hr  (569) embryo 12-14hr  (782) embryo 14-16hr  (724) embryo 16-18hr  (500) embryo 18-20hr  (374) embryo 20-22hr  (269) embryo 22-24hr  (260) larva L1  (337) larva L2  (281) larva L3 12hr old  (255) larva L3 puffstage 1-2  (244) larva L3 puffstage 3-6  (697) larva L3 puffstage 7-9  (978) white prepupae new  (1262) white prepupae 12hr  (793) white prepupae 24hr  (813) pupae 2d postWPP  (615) pupae 3d postWPP  (311) pupae 4d postWPP  (357) adult male 01day  (443) adult male 05day  (411) adult male 30day  (423) adult female 01day  (795) adult female 05day  (1057) adult female 30day  (1085) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    1347 embryo 02-04hr    1098 embryo 04-06hr  (1626) embryo 06-08hr    1300 embryo 08-10hr    1083 embryo 10-12hr    569 embryo 12-14hr    782 embryo 14-16hr    724 embryo 16-18hr    500 embryo 18-20hr    374 embryo 20-22hr    269 embryo 22-24hr    260 larva L1    337 larva L2    281 larva L3 12hr old    255 larva L3 puffstage 1-2    244 larva L3 puffstage 3-6    697 larva L3 puffstage 7-9    978 white prepupae new    1262 white prepupae 12hr    793 white prepupae 24hr    813 pupae 2d postWPP    615 pupae 3d postWPP    311 pupae 4d postWPP    357 adult male 01day    443 adult male 05day    411 adult male 30day    423 adult female 01day    795 adult female 05day    1057 adult female 30day    1085 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    1347 embryo 02-04hr    1098 embryo 04-06hr    1626 embryo 06-08hr    1300 embryo 08-10hr    1083 embryo 10-12hr    569 embryo 12-14hr    782 embryo 14-16hr    724 embryo 16-18hr    500 embryo 18-20hr    374 embryo 20-22hr    269 embryo 22-24hr    260 larva L1    337 larva L2    281 larva L3 12hr old    255 larva L3 puffstage 1-2    244 larva L3 puffstage 3-6    697 larva L3 puffstage 7-9    978 white prepupae new    1262 white prepupae 12hr    793 white prepupae 24hr    813 pupae 2d postWPP    615 pupae 3d postWPP    311 pupae 4d postWPP    357 adult male 01day    443 adult male 05day    411 adult male 30day    423 adult female 01day    795 adult female 05day    1057 adult female 30day    1085 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    1347 embryo 02-04hr    1098 embryo 04-06hr    1626 embryo 06-08hr    1300 embryo 08-10hr    1083 embryo 10-12hr    569 embryo 12-14hr    782 embryo 14-16hr    724 embryo 16-18hr    500 embryo 18-20hr    374 embryo 20-22hr    269 embryo 22-24hr    260 larva L1    337 larva L2    281 larva L3 12hr old    255 larva L3 puffstage 1-2    244 larva L3 puffstage 3-6    697 larva L3 puffstage 7-9    978 white prepupae new    1262 white prepupae 12hr    793 white prepupae 24hr    813 pupae 2d postWPP    615 pupae 3d postWPP    311 pupae 4d postWPP    357 adult male 01day    443 adult male 05day    411 adult male 30day    423 adult female 01day    795 adult female 05day    1057 adult female 30day    1085 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0003048 expression level Developmental Stage   Expression Level embryo 00-02hr    1347 embryo 02-04hr    1098 embryo 04-06hr    1626 embryo 06-08hr    1300 embryo 08-10hr    1083 embryo 10-12hr    569 embryo 12-14hr    782 embryo 14-16hr    724 embryo 16-18hr    500 embryo 18-20hr    374 embryo 20-22hr    269 embryo 22-24hr    260 larva L1    337 larva L2    281 larva L3 12hr old    255 larva L3 puffstage 1-2    244 larva L3 puffstage 3-6    697 larva L3 puffstage 7-9    978 white prepupae new    1262 white prepupae 12hr    793 white prepupae 24hr    813 pupae 2d postWPP    615 pupae 3d postWPP    311 pupae 4d postWPP    357 adult male 01day    443 adult male 05day    411 adult male 30day    423 adult female 01day    795 adult female 05day    1057 adult female 30day    1085 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (1347) embryo 02-04hr  (1098) embryo 04-06hr  (1626) embryo 06-08hr  (1300) embryo 08-10hr  (1083) embryo 10-12hr  (569) embryo 12-14hr  (782) embryo 14-16hr  (724) embryo 16-18hr  (500) embryo 18-20hr  (374) embryo 20-22hr  (269) embryo 22-24hr  (260) larva L1  (337) larva L2  (281) larva L3 12hr old  (255) larva L3 puffstage 1-2  (244) larva L3 puffstage 3-6  (697) larva L3 puffstage 7-9  (978) white prepupae new  (1262) white prepupae 12hr  (793) white prepupae 24hr  (813) pupae 2d postWPP  (615) pupae 3d postWPP  (311) pupae 4d postWPP  (357) adult male 01day  (443) adult male 05day  (411) adult male 30day  (423) adult female 01day  (795) adult female 05day  (1057) adult female 30day  (1085) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    1347 embryo 02-04hr    1098 embryo 04-06hr  1626 embryo 06-08hr    1300 embryo 08-10hr    1083 embryo 10-12hr    569 embryo 12-14hr    782 embryo 14-16hr    724 embryo 16-18hr    500 embryo 18-20hr    374 embryo 20-22hr    269 embryo 22-24hr    260 larva L1    337 larva L2    281 larva L3 12hr old    255 larva L3 puffstage 1-2    244 larva L3 puffstage 3-6    697 larva L3 puffstage 7-9    978 white prepupae new    1262 white prepupae 12hr    793 white prepupae 24hr    813 pupae 2d postWPP    615 pupae 3d postWPP    311 pupae 4d postWPP    357 adult male 01day    443 adult male 05day    411 adult male 30day    423 adult female 01day    795 adult female 05day    1057 adult female 30day    1085 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    1347 embryo 02-04hr    1098 embryo 04-06hr    1626 embryo 06-08hr    1300 embryo 08-10hr    1083 embryo 10-12hr    569 embryo 12-14hr    782 embryo 14-16hr    724 embryo 16-18hr    500 embryo 18-20hr    374 embryo 20-22hr    269 embryo 22-24hr    260 larva L1    337 larva L2    281 larva L3 12hr old    255 larva L3 puffstage 1-2    244 larva L3 puffstage 3-6    697 larva L3 puffstage 7-9    978 white prepupae new    1262 white prepupae 12hr    793 white prepupae 24hr    813 pupae 2d postWPP    615 pupae 3d postWPP    311 pupae 4d postWPP    357 adult male 01day    443 adult male 05day    411 adult male 30day    423 adult female 01day    795 adult female 05day    1057 adult female 30day    1085 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    1347 embryo 02-04hr    1098 embryo 04-06hr    1626 embryo 06-08hr    1300 embryo 08-10hr    1083 embryo 10-12hr    569 embryo 12-14hr    782 embryo 14-16hr    724 embryo 16-18hr    500 embryo 18-20hr    374 embryo 20-22hr    269 embryo 22-24hr    260 larva L1    337 larva L2    281 larva L3 12hr old    255 larva L3 puffstage 1-2    244 larva L3 puffstage 3-6    697 larva L3 puffstage 7-9    978 white prepupae new    1262 white prepupae 12hr    793 white prepupae 24hr    813 pupae 2d postWPP    615 pupae 3d postWPP    311 pupae 4d postWPP    357 adult male 01day    443 adult male 05day    411 adult male 30day    423 adult female 01day    795 adult female 05day    1057 adult female 30day    1085 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0003048    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0003048 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: larval/adult central nervous system, larval Malpighian tubules, larval salivary gland, larval trachea, adult ovary. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0003048 expression level Tissue   Expression Level Larval Central Nervous System    128.475 Larval Midgut    94.2 Larval Hindgut    87.8 Larval Malpighian Tubules    127.1 Larval Fat Body    83 Larval Salivary Gland    133.9 Larval Trachea    104.875 Larval Carcass    90.075 Adult Head    51.8 Adult Eye    50.125 Adult Brain    123.1 Adult Thoracic-Abdominal Ganglion    87.9 Adult Crop    77.4 Adult Midgut    65.8 Adult Hindgut    66.7 Adult Malpighian Tubules    46 Adult Fat Body    96.7 Adult Salivary Gland    68.2 Adult Heart    63.775 Adult VirginFemale Spermatheca    76.3 Adult InseminatedFemale Spermatheca    69.3 Adult Ovary    214 Adult Testis    20.6 Adult Male Accessory Gland    89.6 Adult Carcass    48.6 Expression Level Scale  None   Low   Moderate  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    128.475 Larval Midgut    94.2 Larval Hindgut    87.8 Larval Malpighian Tubules    127.1 Larval Fat Body    83 Larval Salivary Gland    133.9 Larval Trachea    104.875 Larval Carcass    90.075 Adult Head    51.8 Adult Eye    50.125 Adult Brain    123.1 Adult Thoracic-Abdominal Ganglion    87.9 Adult Crop    77.4 Adult Midgut    65.8 Adult Hindgut    66.7 Adult Malpighian Tubules    46 Adult Fat Body    96.7 Adult Salivary Gland    68.2 Adult Heart    63.775 Adult VirginFemale Spermatheca    76.3 Adult InseminatedFemale Spermatheca    69.3 Adult Ovary    214 Adult Testis    20.6 Adult Male Accessory Gland    89.6 Adult Carcass    48.6 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    128.475 Larval Midgut    94.2 Larval Hindgut    87.8 Larval Malpighian Tubules    127.1 Larval Fat Body    83 Larval Salivary Gland    133.9 Larval Trachea    104.875 Larval Carcass    90.075 Adult Head    51.8 Adult Eye    50.125 Adult Brain    123.1 Adult Thoracic-Abdominal Ganglion    87.9 Adult Crop    77.4 Adult Midgut    65.8 Adult Hindgut    66.7 Adult Malpighian Tubules    46 Adult Fat Body    96.7 Adult Salivary Gland    68.2 Adult Heart    63.775 Adult VirginFemale Spermatheca    76.3 Adult InseminatedFemale Spermatheca    69.3 Adult Ovary    214 Adult Testis    20.6 Adult Male Accessory Gland    89.6 Adult Carcass    48.6 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    128.475 Larval Midgut    94.2 Larval Hindgut    87.8 Larval Malpighian Tubules    127.1 Larval Fat Body    83 Larval Salivary Gland    133.9 Larval Trachea    104.875 Larval Carcass    90.075 Adult Head    51.8 Adult Eye    50.125 Adult Brain    123.1 Adult Thoracic-Abdominal Ganglion    87.9 Adult Crop    77.4 Adult Midgut    65.8 Adult Hindgut    66.7 Adult Malpighian Tubules    46 Adult Fat Body    96.7 Adult Salivary Gland    68.2 Adult Heart    63.775 Adult VirginFemale Spermatheca    76.3 Adult InseminatedFemale Spermatheca    69.3 Adult Ovary    214 Adult Testis    20.6 Adult Male Accessory Gland    89.6 Adult Carcass    48.6 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0003048 expression level Tissue   Expression Level Larval Central Nervous System    128.475 Larval Midgut    94.2 Larval Hindgut    87.8 Larval Malpighian Tubules    127.1 Larval Fat Body    83 Larval Salivary Gland    133.9 Larval Trachea    104.875 Larval Carcass    90.075 Adult Head    51.8 Adult Eye    50.125 Adult Brain    123.1 Adult Thoracic-Abdominal Ganglion    87.9 Adult Crop    77.4 Adult Midgut    65.8 Adult Hindgut    66.7 Adult Malpighian Tubules    46 Adult Fat Body    96.7 Adult Salivary Gland    68.2 Adult Heart    63.775 Adult VirginFemale Spermatheca    76.3 Adult InseminatedFemale Spermatheca    69.3 Adult Ovary    214 Adult Testis    20.6 Adult Male Accessory Gland    89.6 Adult Carcass    48.6 Expression Level Scale  None   Low   Moderate  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    128.475 Larval Midgut    94.2 Larval Hindgut    87.8 Larval Malpighian Tubules    127.1 Larval Fat Body    83 Larval Salivary Gland    133.9 Larval Trachea    104.875 Larval Carcass    90.075 Adult Head    51.8 Adult Eye    50.125 Adult Brain    123.1 Adult Thoracic-Abdominal Ganglion    87.9 Adult Crop    77.4 Adult Midgut    65.8 Adult Hindgut    66.7 Adult Malpighian Tubules    46 Adult Fat Body    96.7 Adult Salivary Gland    68.2 Adult Heart    63.775 Adult VirginFemale Spermatheca    76.3 Adult InseminatedFemale Spermatheca    69.3 Adult Ovary    214 Adult Testis    20.6 Adult Male Accessory Gland    89.6 Adult Carcass    48.6 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    128.475 Larval Midgut    94.2 Larval Hindgut    87.8 Larval Malpighian Tubules    127.1 Larval Fat Body    83 Larval Salivary Gland    133.9 Larval Trachea    104.875 Larval Carcass    90.075 Adult Head    51.8 Adult Eye    50.125 Adult Brain    123.1 Adult Thoracic-Abdominal Ganglion    87.9 Adult Crop    77.4 Adult Midgut    65.8 Adult Hindgut    66.7 Adult Malpighian Tubules    46 Adult Fat Body    96.7 Adult Salivary Gland    68.2 Adult Heart    63.775 Adult VirginFemale Spermatheca    76.3 Adult InseminatedFemale Spermatheca    69.3 Adult Ovary    214 Adult Testis    20.6 Adult Male Accessory Gland    89.6 Adult Carcass    48.6 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    128.475 Larval Midgut    94.2 Larval Hindgut    87.8 Larval Malpighian Tubules    127.1 Larval Fat Body    83 Larval Salivary Gland    133.9 Larval Trachea    104.875 Larval Carcass    90.075 Adult Head    51.8 Adult Eye    50.125 Adult Brain    123.1 Adult Thoracic-Abdominal Ganglion    87.9 Adult Crop    77.4 Adult Midgut    65.8 Adult Hindgut    66.7 Adult Malpighian Tubules    46 Adult Fat Body    96.7 Adult Salivary Gland    68.2 Adult Heart    63.775 Adult VirginFemale Spermatheca    76.3 Adult InseminatedFemale Spermatheca    69.3 Adult Ovary    214 Adult Testis    20.6 Adult Male Accessory Gland    89.6 Adult Carcass    48.6 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    51.8   NA  Eye    50.125   NA  Brain    123.1   128.475  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    87.9   NA  Crop    77.4   94.2  Midgut    65.8   87.8  Hindgut    66.7   127.1  Malpighian Tubules    46   83  Fat Body    96.7   133.9  Salivary Gland    68.2   NA  Heart    63.775   104.875  Trachea    NA   NA  VirginFemale Spermatheca    76.3   NA  InseminatedFemale Spermatheca    69.3   NA  Ovary    214   NA  Testis    20.6   NA  Male Accessory Gland    89.6   90.075  Carcass    48.6 modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_06
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0003048 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG3443-RB
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal | embryonic stage | maternal effect | recessive pcx3 pcx4 pcx5 pcx6 pcx7 pcx8 pcx9 pcx10 lethal | maternal effect pcx1 lethal | rescuable maternal effect pcx3 pcx4 pcx5 pcx6 pcx7 pcx8 pcx9 pcx10 viable, with Scer\GAL4pnr-MD237 pcxGD3203 pcxGD5728 pcxGD12502 pcxGD15326 pcxGD15328 Sterility Allele female sterile | recessive pcx3 pcx4 pcx5 pcx6 pcx7 pcx8 pcx9 pcx10 Other Phenotypes Allele visible, with Scer\GAL4pnr-MD237 pcxGD3203 wild-type pcx+tcos9 Phenotype manifest in Allele chaeta | supernumerary, with Scer\GAL4pnr-MD237 pcxGD3203 egg | maternal effect pcx10 pcx3 pcx4 pcx5 pcx6 pcx7 pcx8 pcx9 embryonic/first instar larval cuticle | ventral pcx1 presumptive embryonic/larval central nervous system pcx1
Classical Alleles ( 14 )
For All Classical Alleles Show
Allele of pcx Class Mutagen Stocks Known lesion pcx3 ethyl methanesulfonate 1 -- pcx10 ethyl methanesulfonate 0 -- pcx11 ethyl methanesulfonate 0 -- pcx1 ethyl methanesulfonate 0 -- pcx2 ethyl methanesulfonate 0 -- pcx4 ethyl methanesulfonate 0 -- pcx533 diepoxybutane 0 Yes pcx5 ethyl methanesulfonate 0 -- pcx6 ethyl methanesulfonate 0 -- pcx7 ethyl methanesulfonate 0 -- pcx8 ethyl methanesulfonate 0 -- pcx9 ethyl methanesulfonate 0 -- pcxA387 ethyl methanesulfonate 0 -- pcxunspecified 0 --
Alleles Carried on Transgenic Constructs ( 8 )
For All Alleles Carried on Transgenic Constructs Show
Allele of pcx Class Mutagen Stocks Known lesion pcxGD15326 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes pcxGD15328 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes pcxGD5728 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes pcxGD12502 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes pcxGD3203 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes pcxHM05038 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes pcx+tcos9 in vitro construct - genomic fragment 0 Yes pcxGD15327 in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Not disrupted in	Df(1)2F1-3A4 (Perrimon et al., 1984, Perrimon et al., 1985) Df(1)62g18 (Perrimon et al., 1984) Df(1)JA52 (Perrimon et al., 1985) Df(1)JC19 (Perrimon et al., 1984) Df(1)JC105 (Perrimon et al., 1984, Perrimon et al., 1985, Gandhi et al., 1992) Df(1)JF4   Df(1)l24 (Perrimon et al., 1984, Perrimon et al., 1985) Df(1)L271 (Perrimon et al., 1984, Perrimon et al., 1985) Df(1)Pgd35 (Perrimon et al., 1984) Df(1)TEM75 (Perrimon et al., 1984) Df(1)X12 (Perrimon et al., 1984)
Disrupted in	Df(1)2F1-3A4 (Haenlin et al., 1985) Df(1)64c18 (Perrimon et al., 1984, Perrimon et al., 1985, Gandhi et al., 1992) Df(1)278.4B1 (Perrimon et al., 1984, Perrimon et al., 1985) Df(1)Pgd-kz (Perrimon et al., 1984, Perrimon et al., 1985) Df(1)pn7a (Perrimon et al., 1984, Perrimon et al., 1985) Df(1)pn38 (Perrimon et al., 1985, Smouse and Perrimon, 1990) Df(1)TEM304 (Perrimon et al., 1984, Perrimon et al., 1985) In(1)C99Lwm4R (Perrimon et al., 1985)
Duplicated in	Dp(1;3)wvco (Perrimon et al., 1985) Dp(1;Y)w+303 (Perrimon et al., 1985)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD3203} NA P{GD5728} NA P{GD12502} NA P{GD15326} NA P{GD15327} NA P{GD15328} NA P{TRiP.HM05038} NA
Insertions
	Type of insertions Name Expression data insertion of mobile activating element P{EP}EP426 NA P{EP}EP1460 NA
Gene Ontology: Function, Process & Cellular Component ( 4 unique terms )
Terms Based on Experimental Evidence ( 1 term )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
lateral inhibition inferred from mutant phenotype (Mummery-Widmer et al., 2009)
Cellular Component ( 0 terms)
Terms Based on Predictions or Assertions ( 3 terms )
Molecular Function ( 0 terms)
Biological Process ( 0 terms)
Cellular Component
CV term Evidence References
integral to membrane inferred from electronic annotation with InterPro:IPR007735 (FlyBase Curators et al., 2004-) integral to plasma membrane non-traceable author statement (Swiss-Prot Project Members, 1990.11.1) plasma membrane non-traceable author statement (LaBonne, 1991)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions pcx allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 57742 DroID - A comprehensive database of gene and protein interactions. • FBgn0003048 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 31204
Orthologs
Genome-wide drosophilid orthologs	Dana\GF22205 Dgri\pcx Dper\GL13332 Dpse\GA17455
Curated drosophilid orthologs	Dgri\pcx (Edwards, 1997.1.20) Dpse\GA17455
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AGAP003872-PA Anopheles gambiae (mosquito) XP_624687.2 Apis mellifera (honey bee) XP_001943980.1 Acyrthosiphon pisum (pea aphid) 65764 Branchiostoma floridae (lancelet) BGIBMGA008407-PA Bombyx mori (silk worm) ENSBTAP00000004893 Bos taurus (bovine) CN10156 Caenorhabditis brenneri (small nematode) CBP03045 Caenorhabditis briggsae (nematode) CE28877 Caenorhabditis elegans (worm) ENSCAFP00000024572 Canis familiaris (dog) JA08897 Caenorhabditis japonica (nematode) ENSCPOP00000001634 Cavia porcellus (guinea pig) 221096 Capitella spl (polychaete worm) 322732 Daphnia pulex (daphnia) ENSDARP00000038445 Danio rerio (zebra fish) ENSECAP00000002950 Equus caballus (horse) ENSGACP00000016089 Gymnopilus aculeatus (mushroom) ENSGALP00000000387 Gallus gallus (chicken) 105598 Hypsipyla robusta (cedar shoot borer) ENSP00000304192 Homo sapiens (human) 127487 Lottia gigantea (owl limpet) ENSMODP00000008814 Monodelphis domestica (gray opossum) ENSMMUP00000025590 Macaca mulatta (rhesus monkey) ENSMUSP00000021567 Mus musculus (house mouse) XP_001601737.1 Nasonia vitripennis (wasp) ENSORLP00000011897 Oryzias latipes (japanese killifish) PP16361 Pristionchus pacificus (nematode) ENSPPYP00000006773 Pongo pygmaeus (orangutan) ENSPTRP00000011018 Pan troglodytes (chimpanzee) ENSRNOP00000010022 Rattus norvegicus (norway rat) Smp_130040 Schistosoma mansoni (trematode parasite) XP_784704.2 Strongylocentrotus purpuratus (purple sea urchin) XP_975582.2 Tribolium castaneum (red flour beetle) ENSTNIP00000012895 Tetraodon nigroviridis (green spotted pufferfish) ENSTRUP00000043639 Takifugu rubripes (pufferfish Takifugu) ENSXETP00000047176 Xenopus tropicalis (frog) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • NV15754 LH20307 ISCW001353 FBgn0233790 FBgn0233789 FBgn0227301 FBgn0227300 FBgn0203022 FBgn0203021 FBgn0188201 FBgn0174117 JGI_V11_322732 FBgn0077466 FBgn0150938 FBgn0139179 FBgn0020166 FBgn0105196 FBgn0105195 FBgn0099203 CPIJ012977 CPIJ012976 BGIBMGA008407 ACYPI002301 GB15537 AGAP003872 PB23248 PHUM392310 GLEAN_07308
Stocks & Reagents
Stocks Listed in FlyBase ( 10 )
Bloomington	28552 y1 v1; P{TRiP.HM05038}attP2/TM3, Sb1 4592 y1 pcx3 cv1 v1 f1/FM6
VDRC	v10133 w1118; P{GD3203}v10133 v13905 w1118; P{GD5728}v13905 v14934 w1118; P{GD5728}v14934 v29892 w1118; P{GD15328}v29892 v29893 w1118; P{GD15328}v29893 v42391 w1118; P{GD15326}v42391 v45684 w1118; P{GD12502}v45684 v42392 w1118; P{GD15326}v42392/TM3
Genomic Clones ( 1 )
	BACR48O22 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 28 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	SD01552
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	AT07102 AT13104 AT15720 AT20564 AT22850 GM02474 LD08403 LD27929 LP08074 SD04860 SD14835 SD24828
Other clones	177542 190163 524649 528168 CK01.25A.F2 CK01.77B.G10 CK01.106A.C9 DMG4-chrX.4.012.pred.a EC26747 EK022353 EK060457 EK292362 EN05632 EN08658 MB6-CG3443.a
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0003048 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 31204
Antibody Information
Other Information
Discoverer
	Engstrom (pcx); Romans <up>mel(1)R1</up>.
Etymology
	Because of the mutant phenotype similarities to almondex this locus has been named "pecanex". (Perrimon et al., 1984) Named for its phenotypic resemblance to amx.
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: pcx CG3443 (Deng, 1999.11)
Source for database merge of
Additional comments
Other Comments
	Mutant embryos exhibit hypertrophy of the nervous system and can be rescued by P element carrying wild type genomic region. (Haenlin et al., 1985) Germ line clone analysis establishes that the pcx phenotype is germ line-dependent. (Perrimon et al., 1984)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_080306 RefSeq (Proteins) • NP_525045 DDBJ / EMBL / GenBank • AA949143 AAA28747 AAA28749 AAF45756 AAL13981 AL009171 AL009195 AW944187 AY058752 BG639497 CAA15652 CAA15708 M25662 M74329 Z32056 Entrez Gene - A searchable database of RefSeq genes. • 31204 UniProtKB/Swiss-Prot • P18490
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Pecanex (IPR007735)
Linkouts
	BioGRID - A database of protein and genetic interactions • 57742 DroID - A comprehensive database of gene and protein interactions. • FBgn0003048 DRSC - Results from RNAi screens. • FBgn0003048 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0003048 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG3443-RB FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0003048 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 31204 InParanoid A subset of ortholog calls from InParanoid. • AGAP003872-PA Anopheles gambiae (mosquito) XP_624687.2 Apis mellifera (honey bee) XP_001943980.1 Acyrthosiphon pisum (pea aphid) 65764 Branchiostoma floridae (lancelet) BGIBMGA008407-PA Bombyx mori (silk worm) ENSBTAP00000004893 Bos taurus (bovine) CN10156 Caenorhabditis brenneri (small nematode) CBP03045 Caenorhabditis briggsae (nematode) CE28877 Caenorhabditis elegans (worm) ENSCAFP00000024572 Canis familiaris (dog) JA08897 Caenorhabditis japonica (nematode) ENSCPOP00000001634 Cavia porcellus (guinea pig) 221096 Capitella spl (polychaete worm) 322732 Daphnia pulex (daphnia) ENSDARP00000038445 Danio rerio (zebra fish) ENSECAP00000002950 Equus caballus (horse) ENSGACP00000016089 Gymnopilus aculeatus (mushroom) ENSGALP00000000387 Gallus gallus (chicken) 105598 Hypsipyla robusta (cedar shoot borer) ENSP00000304192 Homo sapiens (human) 127487 Lottia gigantea (owl limpet) ENSMODP00000008814 Monodelphis domestica (gray opossum) ENSMMUP00000025590 Macaca mulatta (rhesus monkey) ENSMUSP00000021567 Mus musculus (house mouse) XP_001601737.1 Nasonia vitripennis (wasp) ENSORLP00000011897 Oryzias latipes (japanese killifish) PP16361 Pristionchus pacificus (nematode) ENSPPYP00000006773 Pongo pygmaeus (orangutan) ENSPTRP00000011018 Pan troglodytes (chimpanzee) ENSRNOP00000010022 Rattus norvegicus (norway rat) Smp_130040 Schistosoma mansoni (trematode parasite) XP_784704.2 Strongylocentrotus purpuratus (purple sea urchin) XP_975582.2 Tribolium castaneum (red flour beetle) ENSTNIP00000012895 Tetraodon nigroviridis (green spotted pufferfish) ENSTRUP00000043639 Takifugu rubripes (pufferfish Takifugu) ENSXETP00000047176 Xenopus tropicalis (frog) InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 31204 modMine - Data generated by the modENCODE project. • FBgn0003048 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • NV15754 LH20307 ISCW001353 FBgn0233790 FBgn0233789 FBgn0227301 FBgn0227300 FBgn0203022 FBgn0203021 FBgn0188201 FBgn0174117 JGI_V11_322732 FBgn0077466 FBgn0150938 FBgn0139179 FBgn0020166 FBgn0105196 FBgn0105195 FBgn0099203 CPIJ012977 CPIJ012976 BGIBMGA008407 ACYPI002301 GB15537 AGAP003872 PB23248 PHUM392310 GLEAN_07308
Synonyms & Secondary IDs ( 18 )
Reported As
Symbol Synonym	CG3443 (Benos, 2000.12.13, Perkins et al., 2009) DMPCX (Schug et al., 1998) EG:30B8.4 (Benos et al., 2001, Benos, 2000.12.13, Benos, 2000.12.13, ) fs(1)12-1012   fs(1)12-1743   fs(1)12-2135   fs(1)12-3014   fs(1)12-3102   fs(1)12-4169   fs(1)14-567   fs(1)14-1153   fs(1)A387   fs(1)M10 (Mohler and Carroll, 1984, Mohler, 1977) fs(1)pcx (Gandhi et al., 1992, Perrimon et al., 1985, Perrimon et al., 1984, ) mel(1)R   mel(1)R1 (Mohler and Carroll, 1984, ) pcx
Name Synonym	pecanex (Edwards et al., 1997)
Secondary FlyBase IDs
	FBgn0000752 FBgn0026853
References ( 51 )
Generate a list of	All references relating to this gene ( 51 )
List References by type	Research paper  ( 24 ) Supplementary material  ( 4 ) Review  ( 4 ) Personal communication to FlyBase  ( 5 ) Abstract  ( 3 ) FlyBase analysis  ( 1 ) Curated genome annotation  ( 1 ) DNA/RNA sequence record  ( 2 ) Protein sequence record  ( 1 ) Book  ( 1 ) Computer file  ( 3 ) Automatic genome annotation  ( 1 )
Recent research papers (0)
	All research papers listed in FlyBase were published before 2010 Show research papers ...
Recent reviews (0)
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