FlyBase Gene Report: Dmel\peb

General Information

Symbol

Dmel\peb

Species

D. melanogaster

Name

pebbled

Annotation Symbol

CG12212

Feature Type

protein_coding_gene

FlyBase ID

FBgn0003053

Gene Model Status

Current

Stock Availability

26 publicly available

Gene Summary

pebbled (peb) encodes a protein that acts as a tissue-specific transcriptional attenuator. It contributes to embryonic morphogenesis and development of ovary, retina and respiratory system. [Date last reviewed: 2019-03-14] (FlyBase Gene Snapshot)

All Summaries

Gene Snapshot
Alliance
Auto summary
Gene Group
Red Book
Interactive Fly

Also Known As

hnt, Hindsight, EP55

Key Links

Genomic Location

Cytogenetic map

4C10-4C10

Sequence location

X:4,617,564..4,627,206 [+]

Recombination map

1-8

RefSeq locus

NC_004354 REGION:4617564..4627206

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

Gene Ontology (GO) Annotations (24 terms)

Molecular Function (2 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

enables DNA-binding transcription activator activity, RNA polymerase II-specific

inferred from biological aspect of ancestor with PANTHER:PTN002509549

(GO Reference Genome Project, 2011-)

enables RNA polymerase II cis-regulatory region sequence-specific DNA binding

inferred from biological aspect of ancestor with PANTHER:PTN002509549

(GO Reference Genome Project, 2011-)

Biological Process (20 terms)

Terms Based on Experimental Evidence (17 terms)

CV Term

Evidence

References

involved_in amnioserosa maintenance

inferred from mutant phenotype

(Frank and Rushlow, 1996)

involved_in compound eye development

inferred from mutant phenotype

(Pickup et al., 2002)

involved_in dorsal closure

inferred from mutant phenotype

(Reed et al., 2001)

involved_in establishment of ommatidial planar polarity

inferred from mutant phenotype

(Pickup et al., 2002)

involved_in germ-band shortening

inferred from mutant phenotype

(Lamka and Lipshitz, 1999, Frank and Rushlow, 1996, Goldman-Levi et al., 1996)

involved_in maintenance of epithelial integrity, open tracheal system

inferred from mutant phenotype

(Wilk et al., 2000)

involved_in negative regulation of JNK cascade

inferred from genetic interaction with FLYBASE:bsk; FB:FBgn0000229

(Reed et al., 2001)

inferred from genetic interaction with FLYBASE:dpp; FB:FBgn0000490

(Reed et al., 2001)

inferred from mutant phenotype

(Melani et al., 2008)

involved_in negative regulation of protein localization to plasma membrane

inferred from mutant phenotype

(Melani et al., 2008)

involved_in negative regulation of receptor signaling pathway via JAK-STAT

inferred from mutant phenotype

(Melani et al., 2008)

involved_in ommatidial rotation

inferred from mutant phenotype

(Pickup et al., 2002)

involved_in open tracheal system development

inferred from expression pattern

(Wilk et al., 2000)

involved_in photoreceptor cell axon guidance

inferred from mutant phenotype

(Oliva et al., 2015)

involved_in photoreceptor cell morphogenesis

inferred from mutant phenotype

(Pickup et al., 2002)

involved_in positive regulation of border follicle cell migration

inferred from mutant phenotype

(Melani et al., 2008)

involved_in positive regulation of epithelial cell-cell adhesion involved in epithelium migration

inferred from mutant phenotype

(Melani et al., 2008)

involved_in positive regulation of homophilic cell adhesion

inferred from mutant phenotype

(Melani et al., 2008)

involved_in wing disc dorsal/ventral pattern formation

inferred from genetic interaction with FLYBASE:dally; FB:FBgn0263930

(Han et al., 2005)

Terms Based on Predictions or Assertions (3 terms)

CV Term

Evidence

References

involved_in head involution

non-traceable author statement

(Frank and Rushlow, 1996)

involved_in regulation of DNA-templated transcription

non-traceable author statement

(Martin and Wood, 2002)

involved_in regulation of transcription by RNA polymerase II

inferred from biological aspect of ancestor with PANTHER:PTN002509549

(GO Reference Genome Project, 2011-)

Cellular Component (2 terms)

Terms Based on Experimental Evidence (2 terms)

CV Term

Evidence

References

located_in nucleus

inferred from direct assay

(Reed et al., 2001, Wilk et al., 2000, Lamka and Lipshitz, 1999, Yip et al., 1997)

located_in polytene chromosome

inferred from direct assay

(Ming et al., 2013)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

is_active_in nucleus

inferred from biological aspect of ancestor with PANTHER:PTN002509549

(GO Reference Genome Project, 2011-)

Gene Group (FlyBase)

C2H2 ZINC FINGER TRANSCRIPTION FACTORS

Protein Family (UniProt)

Protein Signatures (InterPro)

Summaries

Gene Snapshot

Gene Group (FlyBase)

C2H2 ZINC FINGER TRANSCRIPTION FACTORS -: Zinc finger C2H2 transcription factors are sequence-specific DNA binding proteins that regulate transcription. They possess DNA-binding domains that are formed from repeated Cys₂His₂ zinc finger motifs. (Adapted from PMID:1835093, FBrf0220103 and FBrf0155739).

Phenotypic Description (Red Book; Lindsley and Zimm 1992)

hnt: hindsight

Homozygous embryonic lethal; no germ band retraction; embryo U-shaped with head facing posteriorly. Germ line clones obtained; no maternal effect (Perrimon, Engstrom, and Mahowald, 1989, Genetics 121: 333-52).

peb: pebbled

Eyes markedly rough at 28-30, slightly rough (like S) at 25, and wild type at 19. RK2 (28-30).

Summary (Interactive Fly)

multiple zinc finger transcription factor - plays a permissive role facilitating the process of germ band retraction - acts as a tissue-specific transcriptional attenuator. - roles include embryonic morphogenesis and development of ovary, retina and respiratory system

Interactive Fly

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\peb for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry Q9W4J1)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

Comments on Gene Model

Gene model reviewed during 5.52

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

peb-RA

FBtr0070680

NM_057326

6344

1894

peb-RB

FBtr0100265

NM_001014722

7441

1894

Additional Transcript Data and Comments

Reported size (kB)

6.2 (longest cDNA)

(Yip et al., 1997)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

peb-PA

FBpp0070648

205.8

1894

6.21

FBpp0099653

205.8

1894

6.21

Q9W4J1

NP_001014722

AAX52476

Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

1894 aa isoforms: peb-PA, peb-PB

Additional Polypeptide Data and Comments

Reported size (kDa)

1920 (aa)

(Yip et al., 1997)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\peb using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

peb_1

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

0.31

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 4 -- 6

dorsal ectoderm anlage

Comment: anlage in statu nascendi

(Fisher et al., 2012)

posterior ectoderm anlage

Comment: anlage in statu nascendi

(Fisher et al., 2012)

embryonic stage 5

organism | dorsal | posterior

(Sandler and Stathopoulos, 2016)

embryonic stage 5 -- 17

amnioserosa | presumptive

(Yip et al., 1997)

embryonic stage 7 -- 8

amnioserosa anlage

(Fisher et al., 2012)

anterior endoderm anlage

(Fisher et al., 2012)

dorsal ectoderm

(Fisher et al., 2012)

posterior endoderm

(Fisher et al., 2012)

embryonic stage 9 -- 10

amnioserosa primordium

(Fisher et al., 2012)

anterior endoderm

(Fisher et al., 2012)

posterior endoderm

(Fisher et al., 2012)

tracheal primordium

Comment: reported as tracheal system anlage

(Fisher et al., 2012)

embryonic stage 11 -- 12

amnioserosa

(Fisher et al., 2012)

anterior midgut primordium

(Fisher et al., 2012)

Bolwig organ primordium

Comment: reported as larval eye primordium

(Fisher et al., 2012)

dorsal epidermis primordium

(Fisher et al., 2012)

dorsal sensory complex primordium

(Fisher et al., 2012)

posterior midgut primordium

(Fisher et al., 2012)

tracheal primordium

(Fisher et al., 2012)

embryonic stage 13 -- 16

Bolwig organ

(Fisher et al., 2012)

dorsal sensory complex proper primordium

Comment: reported as dorsal/lateral sensory complexes

(Fisher et al., 2012)

embryonic dorsal epidermis

(Fisher et al., 2012)

embryonic head sensory system

(Fisher et al., 2012)

embryonic/larval midgut

(Fisher et al., 2012)

Additional Descriptive Data

peb transcript is detected starting at stage 5 of embryogenesis, in the posterior midgut primordium and in the presumptive amnioserosa, and continues to be detected in these tissues past germ band retraction.

(Yip et al., 1997)

Marker for

posterior midgut primordium

(Hatton-Ellis et al., 2007)

Subcellular Localization

CV Term

Polypeptide Expression

immunolocalization

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 6 -- 17

amnioserosa | presumptive

(Yip et al., 1997)

embryonic stage 8 -- 17

anterior midgut primordium

(Yip et al., 1997)

embryonic stage 10

amnioserosa

(Quijano et al., 2016)

embryonic stage 10 -- 14

amnioserosa

• nucleus

(Reed et al., 2001, Wilk et al., 2000)

embryonic stage 11

embryonic/larval oenocyte precursor | subset

(Brodu et al., 2004)

embryonic stage 11 -- 13

tracheal pit

• nucleus

(Wilk et al., 2000)

embryonic stage 11 -- 14

tracheal primordium

• nucleus

(Wilk et al., 2000)

embryonic stage 11 -- 17

presumptive embryonic/larval peripheral nervous system

(Yip et al., 1997)

larval tracheal system

(Yip et al., 1997)

(Yip et al., 1997)

(Yip et al., 1997)

• nucleus

(Lamka and Lipshitz, 1999)

anterior midgut primordium

• nucleus

(Lamka and Lipshitz, 1999)

posterior midgut primordium

• nucleus

(Lamka and Lipshitz, 1999)

embryonic stage 14

endoderm

(Weiss et al., 2001)

presumptive embryonic/larval tracheal system

• nucleus

(Wilk et al., 2000)

embryonic/larval oenocyte precursor

• nucleus

(Wilk et al., 2000)

embryonic stage 15

larval peripheral nervous system

• nucleus

(Wilk et al., 2000)

embryonic stage 15 -- 17

neuron of peripheral nervous system

(Andrenacci et al., 2004)

embryonic stage 16

embryonic/larval dorsal tracheal branch

• nucleus

(Wilk et al., 2000)

third instar larval stage

embryonic/larval crystal cell

(Fuwa et al., 2015)

tracheolar cell

(Pitsouli and Perrimon, 2010)

embryonic/larval visceral tracheal branch

(Pitsouli and Perrimon, 2010)

embryonic/larval tracheal transverse connective

(Pitsouli and Perrimon, 2010)

oogenesis stage S8 -- S9 & adult stage | female

follicle cell

(Domanitskaya and Schüpbach, 2012)

Additional Descriptive Data

peb protein localizes to the nucleus.

(Domanitskaya and Schüpbach, 2012, Yip et al., 1997)

peb protein is detected starting at stage 6 of embryogenesis, in the posterior midgut primordium and in the presumptive amnioserosa. The amnioserosa expression expands at stage 7. By stage 8, expression is detected in the anterior midgut primordium. Starting at stage 11, expression is detected in the PNS and the tracheal system. Subsequently, CNS and PNS glial cells stain for peb protein. At stage 14, expression is still detected in the CNS, midgut, amnioserosa, PNS and tracheae.

(Yip et al., 1997)

Marker for

amnioserosa

(Quijano et al., 2016, Reed et al., 2001)

embryonic/larval crystal cell

(Fuwa et al., 2015)

endoderm

(Weiss et al., 2001)

Subcellular Localization

CV Term

Evidence

References

located_in nucleus

inferred from direct assay

(Reed et al., 2001, Wilk et al., 2000, Lamka and Lipshitz, 1999, Yip et al., 1997)

located_in polytene chromosome

inferred from direct assay

(Ming et al., 2013)

Expression Deduced from Reporters

Reporter: P{GAL4}peb

Stage

Tissue/Position (including subcellular localization)

Reference

pupal stage

olfactory receptor neuron

(Hong et al., 2009)

adult stage

olfactory receptor neuron

(Sakurai et al., 2009)

adult antennal lobe commissure

(Sakurai et al., 2009)

adult antennal lobe glomerulus

(Sakurai et al., 2009)

adult antennal lobe

(Sakurai et al., 2009)

Reporter: P{GawB}peb^PG37

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage

endoderm

(Denholm et al., 2003)

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\peb in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\peb

View exonic expression by tissue for Dmel\peb

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0003053

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

31391/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0003053

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0003053

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0003053

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG12212

Flygut - An atlas of the Drosophila adult midgut

FBgn0003053

Images

FlyExpress - Embryonic expression images (BDGP data)

Show all FlyExpress processed images for Dmel\peb

Stages(s) 4-6
Stages(s) 7-8
Stages(s) 9-10
Stages(s) 11-12
Stages(s) 13-16

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 42 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 23 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of peb

Transgenic constructs containing regulatory region of peb

Aberrations (Deficiencies and Duplications) ( 49 )

Inferred from experimentation ( 49 )

Gene disrupted in

Df(1)A113

(Harbecke and Lengyel, 1995)

Df(1)bi-D2

(Mevel-Ninio et al., 1995, Oliver et al., 1988)

Df(1)bi-DL3

(Oliver et al., 1988)

Df(1)bi-DL5

(Oliver et al., 1988)

Df(1)BSC532

(Christensen et al., 2008.6.11)

Df(1)BSC580

(Christensen et al., 2008.9.3)

Df(1)BSC657

(Christensen et al., 2008.12.28)

Df(1)cho19

(Steinmann-Zwicky, 1988)

Df(1)cho23

(Steinmann-Zwicky, 1988)

Df(1)EH587

(Yip et al., 1997, Dick et al., 1996, Salz, 1992, Eberl and Hilliker, 1988)

Df(1)GA56

(Oliver et al., 1988)

Df(1)HC244

(Oliver et al., 1988, Steinmann-Zwicky, 1988)

Df(1)HF366

(Oliver et al., 1988, Craymer and Roy, 1980)

Df(1)ovo6

(Oliver et al., 1988, Oliver et al., 1987)

Df(1)ovo7

(Oliver et al., 1988, Oliver et al., 1987)

Df(1)ovo15

(Steinmann-Zwicky, 1988)

Df(1)ovo41

(Steinmann-Zwicky, 1988)

Df(1)ovo44

(Steinmann-Zwicky, 1988)

Df(1)rb1

(Oliver et al., 1988)

Df(1)rb13

(Oliver et al., 1988, Steinmann-Zwicky, 1988)

Df(1)rb14

(Steinmann-Zwicky, 1988)

Df(1)rb23

(Steinmann-Zwicky, 1988)

Df(1)rb29

(Steinmann-Zwicky, 1988)

Df(1)rb30

(Oliver et al., 1988)

Df(1)rb33

(Oliver et al., 1988)

Df(1)rb34

(Steinmann-Zwicky, 1988)

Df(1)rb35

(Steinmann-Zwicky, 1988)

Df(1)rb46

(Oliver et al., 1988)

Df(1)rb47

(Oliver et al., 1988)

Df(1)rb48

(Steinmann-Zwicky, 1988)

Df(1)RC40

(Oliver et al., 1988, Steinmann-Zwicky, 1988, Tearle and Nusslein-Volhard, 1987)

Df(1)Sp(rb)

(Schalet, 1986)

Df(1)w^m258-44

Gene not disrupted in

Gene not duplicated in

Dp(1;2;Y)w⁺

(Eberl and Hilliker, 1988)

Dp(1;2)sn⁺72d

(Eberl and Hilliker, 1988)

Dp(1;2)w-ec

(Schalet, 1986)

Dp(1;3)sn^13a1

(Schalet, 1986)

Gene duplicated in

Dp(1;2)rb⁺71g

(Eberl and Hilliker, 1988)

Dp(1;2)w⁺64b

(Eberl and Hilliker, 1988)

Inferred from location ( 11 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

lethal

lethal, with Scer\GAL4^32B

peb^EP55

lethal, with Scer\GAL4^h-1J3

peb^EP55

lethal, with Scer\GAL4^how-24B

peb^EP55

lethal, with Scer\GAL4^hs.2sev

peb^EP55

lethal, with Scer\GAL4^T80

peb^EP55

lethal | recessive

lethal - all die during embryonic stage

peb¹¹⁴²

lethal - all die during embryonic stage | partially | recessive

peb³⁰⁸

lethal - all die during embryonic stage | recessive

partially lethal - majority die, with Scer\GAL4^69B

peb^EP55

partially lethal - majority die, with Scer\GAL4^GMR.PU

peb^RNAi.UAS.cPa

viable

peb¹

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

peb^GD1507

viable, with Scer\GAL4^Mef2.PR

peb^GD1507

viable, with Scer\GAL4^pnr-MD237

peb^GD1507

viable, with Scer\GAL4^tin.CΔ4

peb^GD1507

Other Phenotypes

Allele

abnormal eye color, with Scer\GAL4^GMR.PU

peb^RNAi.UAS.cPa

abnormal eye color, with Scer\GAL4^lz-gal4

peb^RNAi.UAS.cPa

abnormal neuroanatomy | adult stage, with Scer\GAL4^GMR.PU

peb^GD1507

abnormal neuroanatomy | adult stage, with Spyo\Cas9^ey.3x211

peb^U6:3.gRNA

abnormal neuroanatomy | larval stage, with Spyo\Cas9^SOP.scE1x8

peb^U6:3.gRNA

abnormal oviposition, with Scer\GAL4^GMR44E10

abnormal oviposition, with Scer\GAL4^GMR47A04

abnormal planar polarity

peb¹

abnormal planar polarity | somatic clone

peb^unspecified

increased cell death, with Scer\GAL4^GMR.PU

peb^RNAi.UAS.cPa

majority die during P-stage, with Scer\GAL4^GMR.PU

peb^RNAi.UAS.cPa

melanotic necrosis, with Scer\GAL4^GMR.PU

peb^RNAi.UAS.cPa

some die during embryonic stage | recessive

visible, with Scer\GAL4^69B

peb^EP55

visible, with Scer\GAL4^GMR.PU

peb^RNAi.UAS.cPa

visible, with Scer\GAL4^lz-gal4

peb^RNAi.UAS.cPa

visible (with peb¹)

peb^hnt-1

visible (with peb^hnt-1)

peb¹

visible | heat sensitive

peb¹

visible | somatic clone

wild-type

peb^hs.PY

Phenotype manifest in

Allele

adult olfactory receptor neuron Or22, with Spyo\Cas9^ey.3x211

peb^U6:3.gRNA

amnioserosa

amnioserosa | somatic clone

axon | adult stage, with Scer\GAL4^GMR.PU

peb^GD1507

axon | adult stage, with Spyo\Cas9^ey.3x211

peb^U6:3.gRNA

cephalopharyngeal skeleton

peb^hnt-E8

cephalopharyngeal skeleton | embryonic stage

peb^X001

cuticle

peb^hnt-E8

dendrite | larval stage, with Spyo\Cas9^SOP.scE1x8

peb^U6:3.gRNA

dorsal bridge

peb^hnt-E8

egg chamber | oogenesis stage S14, with Scer\GAL4^GMR44E10

egg chamber | oogenesis stage S14, with Scer\GAL4^GMR47A04

egg chamber | oogenesis stage S14 (with peb¹)

egg chamber | oogenesis stage S14 (with peb^EH704a)

peb¹

egg chamber | oogenesis stage S14 (with peb^hnt-1)

peb¹

embryo | anterior | extended germ band stage

peb^EH704a

embryo | dorsal closure stage

embryo | dorsal closure stage | somatic clone

embryo | extended germ band stage | somatic clone

embryonic/first instar larval cuticle

peb^EH704a

embryonic/first instar larval cuticle | dorsal

embryonic/larval tracheal dorsal trunk

embryonic head

peb^hnt-E8

eye, with Scer\GAL4^69B

peb^EP55

eye, with Scer\GAL4^GMR.PU

peb^RNAi.UAS.cPa

eye, with Scer\GAL4^lz-gal4

peb^RNAi.UAS.cPa

eye (with peb¹)

peb^hnt-1

eye (with peb^hnt-1)

peb¹

eye | heat sensitive

peb¹

eye | somatic clone

eye photoreceptor cell | adult stage, with Scer\GAL4^GMR.PU

peb^GD1507

eye photoreceptor cell | somatic clone

filzkorper

peb^hnt-E8

five-cell ommatidial precursor cluster | somatic clone

peb^hnt-1

germ band

interommatidial bristle

peb¹

larval dorsal multidendritic neuron ddaC, with Spyo\Cas9^SOP.scE1x8

peb^U6:3.gRNA

larval tracheal system

larval tracheal system | posterior

lens, with Scer\GAL4^GMR.PU

peb^RNAi.UAS.cPa

mitotic domain 1 | extended germ band stage

ommatidial precursor cluster | heat sensitive

peb¹

ommatidial precursor cluster | somatic clone

ommatidium | heat sensitive

peb¹

oocyte associated follicular epithelium | oogenesis stage S14, with Scer\GAL4^GMR44E10

oocyte associated follicular epithelium | oogenesis stage S14, with Scer\GAL4^GMR47A04

oocyte associated follicular epithelium | oogenesis stage S14 (with peb¹)

oocyte associated follicular epithelium | oogenesis stage S14 (with peb^EH704a)

peb¹

oocyte associated follicular epithelium | oogenesis stage S14 (with peb^hnt-1)

peb¹

ovarian basement membrane | oogenesis stage S14, with Scer\GAL4^GMR47A04

rhabdomere

peb¹

rhabdomere | somatic clone

peb^unspecified

peb^hnt-E8

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (63)

Hsap\RREB1

10 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Hsap\PRDM15

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Hsap\ZBTB39

1 of 14

Yes

Hsap\ZBTB40

1 of 14

Yes

Hsap\ZBTB49

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Hsap\ZNF341

1 of 14

Hsap\ZNF398

1 of 14

Hsap\ZNF416

1 of 14

Yes

Hsap\ZNF426

1 of 14

Yes

Hsap\ZNF497

1 of 14

Hsap\ZNF500

1 of 14

Hsap\ZNF501

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Hsap\ZSCAN21

1 of 14

Hsap\ZXDA

1 of 14

Hsap\ZXDB

1 of 14

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (17)

Rnor\Rreb1

10 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Rnor\Zbtb49

1 of 14

Yes

Rnor\Zfp78

1 of 14

Rnor\Zfp398

1 of 14

Rnor\Zfp467

1 of 14

Yes

Rnor\Zfp523

1 of 14

Yes

Rnor\Zic3

1 of 14

Rnor\Zxdc

1 of 14

Mus musculus (laboratory mouse) (18)

Mmus\Rreb1

9 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Mmus\Zbtb49

1 of 14

Yes

Mmus\Zfp398

1 of 14

Mmus\Zfp467

1 of 14

Yes

Mmus\Zfp523

1 of 14

Yes

Mmus\Zfp775

1 of 14

Yes

Mmus\Zfp865

1 of 14

Yes

Mmus\Zfpm1

1 of 14

Mmus\Zic3

1 of 14

Mmus\Zxdc

1 of 14

Xenopus tropicalis (Western clawed frog) (24)

Xtro\rreb1

7 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Xtro\LOC100498654

1 of 13

Yes

Xtro\LOC101731232

1 of 13

Xtro\LOC101731414

1 of 13

Yes

Xtro\mtf1

1 of 13

Xtro\mynn

1 of 13

Xtro\prdm15

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Xtro\znf574

1 of 13

Xtro\znf592

1 of 13

Danio rerio (Zebrafish) (49)

Drer\rreb1a

11 of 14

Yes

Drer\rreb1b

11 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Drer\LOC100536922

1 of 14

Drer\LOC100537361

1 of 14

Drer\LOC101883936

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Drer\si:cabz01069022.1

1 of 14

Yes

Drer\si:ch73-40a17.4

1 of 14

Drer\si:ch73-144d13.7

1 of 14

Yes

Drer\si:ch73-158p21.7

1 of 14

Drer\si:ch73-299h12.4

1 of 14

Yes

Drer\si:ch211-222k6.2

1 of 14

Yes

Drer\si:ch211-229l10.11

1 of 14

Drer\si:ch211-241b2.1

1 of 14

Yes

Drer\si:dkeyp-84f3.9

1 of 14

Yes

Drer\si:zfos-932h1.3

1 of 14

Drer\wu:fc30c06

1 of 14

Drer\zbtb24

1 of 14

Yes

Drer\zgc:113443

1 of 14

Drer\zgc:173517

1 of 14

Drer\zgc:173575

1 of 14

Yes

Drer\zgc:174624

1 of 14

Drer\zic2b

1 of 14

Drer\znf143a

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Caenorhabditis elegans (Nematode, roundworm) (13)

Cele\fezf-1

1 of 14

Yes

Cele\ham-2

1 of 14

Yes

Cele\klf-1

1 of 14

Yes

Cele\klu-1

1 of 14

Yes

Cele\lsy-27

1 of 14

Yes

Cele\pzf-1

1 of 14

Yes

Cele\ref-2

1 of 14

Yes

Cele\scrt-1

1 of 14

Yes

Cele\sdz-38

1 of 14

Yes

Cele\ztf-25

1 of 14

Yes

Cele\ztf-28

1 of 14

Yes

Cele\ztf-29

1 of 14

Yes

Cele\ztf-30

1 of 14

Yes

Anopheles gambiae (African malaria mosquito) (25)

Agam\AgaP_AGAP000984

10 of 12

Yes

1 of 12

1 of 12

1 of 12

1 of 12

Yes

Agam\AgaP_AGAP004714

1 of 12

Agam\AgaP_AGAP004764

1 of 12

Yes

1 of 12

1 of 12

1 of 12

1 of 12

Yes

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Yes

Agam\AgaP_AGAP008796

1 of 12

Yes

Agam\AgaP_AGAP009096

1 of 12

Agam\AgaP_AGAP009481

1 of 12

Yes

Agam\AgaP_AGAP009484

1 of 12

Yes

1 of 12

1 of 12

1 of 12

1 of 12

Arabidopsis thaliana (thale-cress) (0)

Saccharomyces cerevisiae (Brewer's yeast) (0)

Schizosaccharomyces pombe (Fission yeast) (0)

Escherichia coli (enterobacterium) (0)

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:peb. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (24)

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Cph

1 of 13

D19A

1 of 13

esg

1 of 13

grau

1 of 13

ham

1 of 13

jim

1 of 13

Kah

1 of 13

odd

1 of 13

pho

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

sug

1 of 13

trem

1 of 13

wor

1 of 13

Zif

1 of 13

ZIPIC

1 of 13

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

RREB1; ras responsive element binding protein 1

10 of 14

602209

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Dmel gene

Ortholog showing functional complementation

Supporting References

peb

Hsap\RREB1

(Deady et al., 2017, Ming et al., 2013)

Interactions

Summary of Physical Interactions

esyN Network Diagram

Show neighbor-neighbor interactions:

Off

Show/hide secondary interactors
(data from AllianceMine provided by esyN)

Select Layout:

Force Directed

Circle

Concentric

Legend:

Protein

RNA

Selected Interactor(s)

Other Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

peb - Ada2b

anti tag coimmunoprecipitation, peptide massfingerprinting

(Weake et al., 2011)

peb - Ets65A

two hybrid array

(Shokri et al., 2019)

peb - Rel

two hybrid array

(Shokri et al., 2019)

peb - org-1

two hybrid array

(Shokri et al., 2019)

Summary of Genetic Interactions

esyN Network Diagram

Show/hide secondary interactors
(data from AllianceMine provided by esyN)

esyN Network Key:

Suppression

Enhancement

Other Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

peb

suppressible

Acsl

(Wilk et al., 2004)

peb

suppressible

aop

(Wilk et al., 2004)

peb

suppressible

aPKC

(Wilk et al., 2004)

peb

suppressible

apt

(Wilk et al., 2004)

peb

suppressible

babo

(Wilk et al., 2004)

peb

suppressible

blw

(Wilk et al., 2004)

peb

suppressible

bsk

(Pickup et al., 2002, Reed et al., 2001)

peb

suppressible

cact

(Wilk et al., 2004)

peb

enhanceable

chic

(Wilk et al., 2004)

peb

suppressible

chic

(Wilk et al., 2004)

peb

suppressible

chn

(Wilk et al., 2004)

peb

suppressible

Col4a1

(Wilk et al., 2004)

peb

suppressible

Coprox

(Wilk et al., 2004)

peb

suppressible

CycE

(Wilk et al., 2004)

peb

suppressible

Cyt-c-p

(Wilk et al., 2004)

peb

suppressible

dac

(Wilk et al., 2004)

peb

suppressible

DCTN2-p50

(Wilk et al., 2004)

peb

suppressible

Delta

(Pickup et al., 2009, Wilk et al., 2004)

peb

enhanceable

Delta

(Wilk et al., 2004)

peb

suppressible

dom

(Wilk et al., 2004)

peb

enhanceable

dpp

(Reed et al., 2001)

peb

suppressible

dpp

(Reed et al., 2001)

peb

suppressible

dve

(Wilk et al., 2004)

peb

suppressible

(Wilk et al., 2004)

peb

enhanceable

Egfr

(Wilk et al., 2004)

peb

suppressible

eIF4A

(Wilk et al., 2004)

peb

suppressible

eRF1

(Wilk et al., 2004)

peb

enhanceable

(Wilk et al., 2004)

peb

suppressible

heix

(Wilk et al., 2004)

peb

suppressible

Hel25E

(Wilk et al., 2004)

peb

suppressible

InR

(Lamka and Lipshitz, 1999)

peb

suppressible

jbug

(Oliva et al., 2015)

peb

suppressible

Jra

(Wilk et al., 2004, Pickup et al., 2002)

peb

enhanceable

kst

(Wilk et al., 2004)

peb

suppressible

kst

(Wilk et al., 2004)

peb

suppressible

l(2)00297

(Wilk et al., 2004)

peb

suppressible

l(2)k00605b

(Wilk et al., 2004)

peb

suppressible

l(2)k00611

(Wilk et al., 2004)

peb

suppressible

l(2)k06617

(Wilk et al., 2004)

peb

suppressible

l(2)k10001

(Wilk et al., 2004)

peb

suppressible

l(2)k10113

(Wilk et al., 2004)

peb

suppressible

l(2)k15826

(Wilk et al., 2004)

peb

suppressible

l(2)s1878

(Wilk et al., 2004)

peb

suppressible

l(3)L3930

(Wilk et al., 2004)

peb

suppressible

l(3)neo51

(Wilk et al., 2004)

peb

suppressible

LanA

(Wilk et al., 2004)

peb

suppressible

MESK2

(Wilk et al., 2004)

peb

suppressible

ms(3)neo94

(Wilk et al., 2004)

peb

suppressible

Mtpβ

(Wilk et al., 2004)

peb

suppressible

ND-PDSW

(Wilk et al., 2004)

peb

suppressible

not

(Wilk et al., 2004)

peb

suppressible

Nse1

(Wilk et al., 2004)

peb

suppressible

Oamb

(Deady et al., 2017)

peb

enhanceable

osa

(Wilk et al., 2004)

peb

enhanceable

(Wilk et al., 2004)

peb

suppressible

puc

(Wilk et al., 2004)

peb

suppressible

(Wilk et al., 2004)

peb

suppressible

rept

(Wilk et al., 2004)

peb

suppressible

retn

(Wilk et al., 2004)

peb

suppressible

Rho1

(Wilk et al., 2004)

peb

enhanceable

rols

(Wilk et al., 2004)

peb

suppressible

Rpn6

(Wilk et al., 2004)

peb

suppressible

RyR

(Wilk et al., 2004)

peb

suppressible

Sec61α

(Wilk et al., 2004)

peb

suppressible

Sec61β

(Wilk et al., 2004)

peb

suppressible

slbo

(Wilk et al., 2004)

peb

enhanceable

srp

(Goldman-Levi et al., 1996)

peb

suppressible

tkv

(Wilk et al., 2004)

peb

suppressible

tutl

(Wilk et al., 2004)

peb

suppressible

unch

(Wilk et al., 2004)

peb

enhanceable

ush

(Goldman-Levi et al., 1996)

peb

suppressible

vkg

(Wilk et al., 2004)

peb

enhanceable

vkg

(Wilk et al., 2004)

peb

suppressible

vri

(Wilk et al., 2004)

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

suppressible

peb

(Knapp et al., 2019)

External Data

Linkouts

BioGRID - A database of protein and genetic interactions.

57908

DroID - A comprehensive database of gene and protein interactions.

FBgn0003053

MIST (genetic) - An integrated Molecular Interaction Database

31391

MIST (protein-protein) - An integrated Molecular Interaction Database

31391

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

FlyBase

External Links

External Data

Linkouts

KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.

MAPK signaling pathway - fly

Class of Gene

nuclear_gene

protein_coding_gene

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

1-8

Cytogenetic map

4C10-4C10

Sequence location

X:4,617,564..4,627,206 [+]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

4C10-4C10

Limits computationally determined from genome sequence between P{EP}CG2930^EP1352 and P{EP}EP425

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

4C5-4C6

(Yip, 1997.1.21)

4C5-4C6

(determined by in situ hybridisation)

(Rorth, 1996, Yip and Lipshitz, 1992, Yip and Fisher, 1991)

Experimentally Determined Recombination Data

Location

1-8

(FlyBase, 2016)

1-7.6

(Comeron et al., 2012)

1-7

(Tearle and Nusslein-Volhard, 1987)

1-7.5+

(Schalet, 1986)

Left of (cM)

(Schalet, 1986)

Right of (cM)

(Schalet, 1986)

Notes

Stocks and Reagents

Stocks (26)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Bloomington

peb¹ v¹

3241

y¹ peb^hnt-E8/FM7c

Korea

11988

P{VT056867-GAL4}attP2

11989

P{VT056876-GAL4}attP2

14542

P{VT056867-lexA}attP2

11445

P{EP}peb^G11173

15861

P{VT056867-lexA::GADfl}attP40

Kyoto

105720

peb¹ v¹

106936

y¹ peb^hnt-E8/FM7c

VDRC

v101325

P{KK107575}VIE-260B

v205020

P{VT056866-GAL4}attP2

v3788

w¹¹¹⁸; P{GD1507}v3788

More stocks available...

Genomic Clones (13)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (44)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

GH10905

Other clones

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0003053

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0003053

Antibody Information

Laboratory Generated Antibodies

monoclonal

(Yip et al., 1997)

Commercially Available Antibodies

Developmental Studies Hybridoma Bank - Monoclonal antibodies for use in research

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

peb has many functions during eye development. peb is required immediately posterior to the morphogenetic furrow for the correct morphology and arrangement of cells in the ommatidial precluster (which contains the R8, R2, R5, R3 and R4 precursors). peb is also required in the outer photoreceptor cells for establishment of correct chirality and the rotation of ommatidia. peb is required to maintain ommatidial structure and integrity during the mid-pupal stage. peb is required in each photoreceptor cell to accomplish apical-basal extension of the cell and its rhabdomere during the pupal period. peb is required for the separation of neighbouring rhabdomeres that occurs during the late pupal period.

(Pickup et al., 2002)

peb is a tissue specific factor that may regulate maintenance of the tracheal epithelium as well as differentiation of taenidia.

(Wilk et al., 2000)

Kr is activated by peb in the amnioserosa.

(Lamka and Lipshitz, 1999)

In peb mutants the amnioserosa undergoes premature cell death.

(Lamka and Lipshitz, 1999)

peb activity in the amnioserosa, particularly in those cells adjacent to the epidermis, is necessary for germ band retraction.

(Lamka and Lipshitz, 1999)

peb has been cloned and characterised.

(Yip et al., 1997)

A member of the ush-group of genes which are required for maintenance of the amnioserosa once it has differentiated.

(Frank and Rushlow, 1996)

Mutants affect amnioserosa differentiation as well as germ band retraction.

(Frank and Rushlow, 1995)

peb gene encodes a putative zinc finger transcription factor expressed in specific glial in the developing CNS. Lack of peb protein alters the migration of axons which grow across the glia.

(Lamka and Lipshitz, 1995)

Muscle phenotype of mutants studied using polarised light microscopy and antibody staining to detect Mhc-lacZ reporter gene expression in muscles.

(Drysdale et al., 1993)

Mutations in peb generate malformations of the longitudinal tracts.

(Jacobs, 1993)

Zygotically active locus involved in the terminal developmental program in the embryo.

(Strecker et al., 1991)

Mutations of the zygotic loci peb specifically affect germband retraction.

(Yip and Lipshitz, 1991)

A screen for X-linked genes that affect embryo morphology revealed peb.

(Eberl and Hilliker, 1988)

peb mutants display no germ band retraction, embryos are 'U-shaped' with a head facing the posterior end.

(Wieschaus et al., 1984)

Relationship to Other Genes

Source for database merge of

Additional comments

"l(1)G0288" may affect "peb". "l(1)G0273" may affect "peb". "l(1)G0304" may affect "peb".

(Peter et al., 2002)

Nomenclature History

Source for database identify of

Nomenclature comments

Etymology

Synonyms and Secondary IDs (17)

Reported As

Symbol Synonym

CG12212

(Hosono et al., 2015, Ni et al., 2010.12.1, Keleman et al., 2009.8.5, Krejcí et al., 2009, Perkins et al., 2009, Quinones-Coello, 2007, Bourbon et al., 2002)

EG:66A1.1

EP55

(Reed et al., 2001)

HNT

(Ming et al., 2007, Reed et al., 2004, Brown and Castelli-Gair Hombria, 2000)

Hin

(Stinchfield et al., 2012)

Hind

(Andrenacci et al., 2004)

Hnt

(Lin et al., 2024, Luo et al., 2024, D'Souza et al., 2022, Li et al., 2022, Bailey et al., 2021, Frankenreiter et al., 2021, Pitsidianaki et al., 2021, Fic et al., 2019, Lo et al., 2019, Bohère et al., 2018, Li et al., 2018, Yu et al., 2018, Saadin and Starz-Gaiano, 2016, Gómez-Lamarca et al., 2014, Huang et al., 2014, Tognon et al., 2014, Xie et al., 2014, Huang et al., 2013, Schneider et al., 2013, Heck et al., 2012, Mitra et al., 2012, Rebeiz et al., 2012, Stinchfield et al., 2012, Tokusumi et al., 2012, Troost and Klein, 2012, Wong et al., 2012, Yang et al., 2012, Banks et al., 2011, Duan et al., 2011, Klusza and Deng, 2011, Li et al., 2011, Poulton et al., 2011, Sun et al., 2011, Takemura and Adachi-Yamada, 2011, Yan et al., 2011, Genevet et al., 2010, Monastirioti et al., 2010, Richardson and Pichaud, 2010, Yu et al., 2010, Li et al., 2009, Rajan et al., 2009, Urbano et al., 2009, Yan et al., 2009, Zúñiga et al., 2009, Chang et al., 2008, Kaspar et al., 2008, Sun et al., 2008, Tian and Deng, 2008, Vaccari et al., 2008, Yu et al., 2008, Meignin et al., 2007, Polesello and Tapon, 2007, Sun and Deng, 2007, Rives et al., 2006, Rusten et al., 2006, Sun et al., 2006, Castro et al., 2005, Gomes and Schweisguth, 2005, Han et al., 2005, Koelzer and Klein, 2003, Lai, 2003)

PEB

(Boube et al., 2000)

Peb

(Li et al., 2024, Wong et al., 2023, Mishra et al., 2016, Yuan et al., 2015, Raja et al., 2010)

anon-4Cg

hnd

(Ross et al., 2001)

hnt

(Forbes Beadle et al., 2023, Oramas et al., 2023, Li et al., 2022, Girard et al., 2021, Hoppe et al., 2020, Kim et al., 2020, Ng et al., 2020, Jeong et al., 2019, Knapp et al., 2019, Sajwan and Mannervik, 2019, Szablewski and Reed, 2019, Obniski et al., 2018, Sandler et al., 2018, Deady et al., 2017, Sandler and Stathopoulos, 2016, Flores-Benitez and Knust, 2015, Legent et al., 2015, Lin et al., 2015, Newton et al., 2015, Oliva et al., 2015, Sawala et al., 2015, Jia et al., 2014, Lee and Spradling, 2014, Ming et al., 2013, Saunders et al., 2013, Sun and Spradling, 2013, Terriente-Felix et al., 2013, Domanitskaya and Schüpbach, 2012, Oliva and Sierralta, 2010, Vaccari et al., 2010, Windler and Bilder, 2010, Krejcí et al., 2009, Pickup et al., 2009, Melani et al., 2008, Miles et al., 2008, Ming et al., 2008, Wang et al., 2008, Fernández et al., 2007, Sun and Deng, 2007, Melani and Montell, 2006, Levine and Davidson, 2005, Scuderi and Letsou, 2005, Stathopoulos and Levine, 2005, Brodu et al., 2004, Paladi and Tepass, 2004, Wilk et al., 2004, Wilk et al., 2004, Ghabrial et al., 2003, Reim et al., 2003, Beller et al., 2002, Beller et al., 2002, Martin and Wood, 2002, Pickup et al., 2002, Reed et al., 2001, Reed et al., 2001, Ashe et al., 2000, Lammel and Saumweber, 2000, Pickup and Lipshitz, 2000, Wilk et al., 2000, Lamka, 1999, Lamka and Lipshitz, 1999, Reed et al., 1999, Scherer and Duffy, 1999, Wilk and Lipshitz, 1999, Lamka and Lipshitz, 1998, Reed et al., 1998, Sigrist and Lehner, 1997, Goldman-Levi et al., 1996, Martinez Arias, 1993, Tearle and Nusslein-Volhard, 1987, Wieschaus et al., 1984)

peb

(Hersperger et al., 2024, Miao et al., 2024, Sood et al., 2024, Hultmark and Andó, 2022, Jia et al., 2022, Ji et al., 2022, Perlegos et al., 2022, Alsous et al., 2021, Girard et al., 2021, Ing-Simmons et al., 2021, Scholl et al., 2021, Slaidina et al., 2021, Burdett and Freeman, 2020.2.28, Cho et al., 2020, Earl et al., 2020, Hung et al., 2020, Banerjee et al., 2019, Gahr et al., 2019, Liu et al., 2019, Sapar and Han, 2019, Shokri et al., 2019, Abrat et al., 2018, Farley et al., 2018, Kendroud et al., 2018, Karaiskos et al., 2017, Transgenic RNAi Project members, 2017-, Öztürk-Çolak et al., 2016, Kang et al., 2015, model organism Encyclopedia of Regulatory Network (modERN) Project, 2015-, Nadimpalli et al., 2015, Ríos-Barrera et al., 2015, Georgieva et al., 2014, Terriente-Felix et al., 2013, Terriente-Felix et al., 2013, Zhou et al., 2012, Weake et al., 2011, Buffin and Gho, 2010, Krejcí et al., 2009, Christensen et al., 2008.6.11, Christensen et al., 2008.9.3, Christensen et al., 2008.12.28, Wang et al., 2008, Quinones-Coello, 2007, Bilen et al., 2006, Negre et al., 2006, Reeves and Posakony, 2005)

Name Synonyms

Hindsight

(Khadilkar et al., 2020, Yu et al., 2018, Quijano et al., 2016, Hsiao et al., 2014, Wisotzkey et al., 2014, Xie et al., 2014, Huang et al., 2013, Barth et al., 2012, Stinchfield et al., 2012, Wong et al., 2012, Banks et al., 2011, Duan et al., 2011, Pi et al., 2011, Pocha et al., 2011, Poulton et al., 2011, Sun et al., 2011, Takemura and Adachi-Yamada, 2011, Genevet et al., 2010, Richardson and Pichaud, 2010, Yu et al., 2010, Li et al., 2009, Rajan et al., 2009, Urbano et al., 2009, Yan et al., 2009, Zúñiga et al., 2009, Sun et al., 2008, Tian and Deng, 2008, Vaccari et al., 2008, Yu et al., 2008, Ayyar et al., 2007, Meignin et al., 2007, Polesello and Tapon, 2007, Sun and Deng, 2007, Sun and Deng, 2007, Rives et al., 2006, Rusten et al., 2006, Sun et al., 2006, Jacinto et al., 2002, Tepass et al., 2001, Weiss et al., 2001)

Pebbled

(Gahr et al., 2019, Gómez-Lamarca et al., 2014, Huang et al., 2014, Poulton et al., 2011, Takemura and Adachi-Yamada, 2011, Richardson and Pichaud, 2010, Pickup et al., 2009)

pebbled

(Regadas et al., 2021, Koranteng et al., 2020, Abrat et al., 2018, Kendroud et al., 2018, Buffin and Gho, 2010, Oliva and Sierralta, 2010, Vaccari et al., 2010, Windler and Bilder, 2010, Krejcí et al., 2009, Negre et al., 2006)

Secondary FlyBase IDs

FBgn0001209
FBgn0019888

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 44 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

31391

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

Q9W4J1

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

Q9W4J1

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0003053

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

31391/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0003053

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0003053

FlyMine - An integrated database for Drosophila genomics

FBgn0003053

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG12212

MARRVEL_MODEL - MARRVEL (model organism gene)

31391

Linkouts

BioGRID - A database of protein and genetic interactions.

57908

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0003053

DroID - A comprehensive database of gene and protein interactions.

FBgn0003053

DRSC - Results frm RNAi screens

FBgn0003053

Developmental Studies Hybridoma Bank - Monoclonal antibodies for use in research

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

peb_1

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0003053

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0003053

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG12212

Flygut - An atlas of the Drosophila adult midgut

FBgn0003053

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

TC009560

Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution

Interactive Fly

KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.

MAPK signaling pathway - fly

MIST (genetic) - An integrated Molecular Interaction Database

31391

MIST (protein-protein) - An integrated Molecular Interaction Database

31391

References (321)

The following external sites may use different assemblies or annotations than FlyBase.

0.31

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