hnt, Hindsight, EP55
multiple zinc finger transcription factor - plays a permissive role facilitating the process of germ band retraction - acts as a tissue-specific transcriptional attenuator. - roles include embryonic morphogenesis and development of ovary, retina and respiratory system
Gene model reviewed during 5.52
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\peb using the Feature Mapper tool.
peb protein is detected starting at stage 6 of embryogenesis, in the posterior midgut primordium and in the presumptive amnioserosa. The amnioserosa expression expands at stage 7. By stage 8, expression is detected in the anterior midgut primordium. Starting at stage 11, expression is detected in the PNS and the tracheal system. Subsequently, CNS and PNS glial cells stain for peb protein. At stage 14, expression is still detected in the CNS, midgut, amnioserosa, PNS and tracheae.
GBrowse - Visual display of RNA-Seq signalsView Dmel\peb in GBrowse 2
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
"l(1)G0288" may affect "peb". "l(1)G0273" may affect "peb". "l(1)G0304" may affect "peb".
peb has many functions during eye development. peb is required immediately posterior to the morphogenetic furrow for the correct morphology and arrangement of cells in the ommatidial precluster (which contains the R8, R2, R5, R3 and R4 precursors). peb is also required in the outer photoreceptor cells for establishment of correct chirality and the rotation of ommatidia. peb is required to maintain ommatidial structure and integrity during the mid-pupal stage. peb is required in each photoreceptor cell to accomplish apical-basal extension of the cell and its rhabdomere during the pupal period. peb is required for the separation of neighbouring rhabdomeres that occurs during the late pupal period.
peb is a tissue specific factor that may regulate maintenance of the tracheal epithelium as well as differentiation of taenidia.
peb activity in the amnioserosa, particularly in those cells adjacent to the epidermis, is necessary for germ band retraction.
A member of the ush-group of genes which are required for maintenance of the amnioserosa once it has differentiated.
Mutants affect amnioserosa differentiation as well as germ band retraction.
Muscle phenotype of mutants studied using polarised light microscopy and antibody staining to detect Mhc-lacZ reporter gene expression in muscles.
Mutations in peb generate malformations of the longitudinal tracts.
Zygotically active locus involved in the terminal developmental program in the embryo.
A screen for X-linked genes that affect embryo morphology revealed peb.