• Home
• Tools
  • Tools Overview
  • Query Tools

    
    • QuickSearch
    • QueryBuilder
    • TermLink
    • CytoSearch
    • Interactions Browser
    • ImageBrowse
    • Find A Person
    • Google™ FlyBase
  • Genomic/Map Tools

    
    • BLAST
    • GBrowse
    • CytoSearch
    • Aberrations Maps
    • Chromosome Maps
    • Coordinates Converter
  • Retrieve/Convert

    
    • Batch Download
    • Coordinates Converter
    • ID Converter
  • Data Submission

    
    • Fast-Track Your Paper
    • Submit Personal Comm
    • Add A New Person
    • Update Person Info
  • People

    
    • Find A Person
    • Add A New Person
    • Update Person Info
• Files
  • Files Overview
  • Downloads:
  • Precomputed files
  • Archived data
  • Releases (FTP)
  • Genomes (FTP)
  • AAA data (FTP)
  • Lists:
  • Transposons (Dmel)
  • Transposons (other)
  • Vectors & Constructs
  • Anatomical Terms
  • Map Conversion
• Species
  • Phylogeny
  • Sequenced Species
  • Synteny Table
  • Color Illustrations
  • Abbreviations
• Documents
  • About FlyBase
  • Reference Manual:
  • Sections
  • Contents
  • Nomenclature
  • Release Notes
• Resources
  • All Resources
  • Model Organisms
  • Stock Collections
  • Other links:
  • BDGP
  • DGRC
  • FlyExpress
  • Interactive Fly
  • modENCODE
  • Textpresso for Fly
• News
  • News
  • FlyBase Forum
  • FlyBase Positions
  • Meetings
  • Courses
  • Fly Board
  • White papers
  • Funding
  • bionet.dros
• Help
  • Google™ FlyBase
  • Site Map
  • FAQs
  • FlyBase Guides
  • Video Tutorials
  • Report help
  • New to Flies
  • Pers. comm.
  • Author guidelines
  • Contact FlyBase
• Archives
  • Prior Release
  • Other Archives
  • Coordinate Converter

Gene Dmel\Pepck

General Information
Symbol	Dmel\Pepck	Species	D. melanogaster
Name	Phosphoenolpyruvate carboxykinase	Annotation symbol	CG17725
Feature type	protein_coding_gene	FlyBase ID	FBgn0003067
Gene Model Status	Current	Stock availability	4 publicly available
Genomic Location
Chromosome (arm)	2R	Recombination map
Cytogenetic map	55D3-55D3	Sequence location	2R:14,424,272..14,426,924 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Phosphoenolpyruvate carboxykinase is referred to in FlyBase by the symbol Dmel\Pepck (CG17725, FBgn0003067). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: phosphoenolpyruvate carboxykinase (GTP) activity. Based on sequence similarity, it is predicted to be involved in the biological process: gluconeogenesis. 3 alleles are reported. No phenotypic data is available. It has 2 annotated transcripts and 2 annotated polypeptides. Protein features are: Phosphoenolpyruvate carboxykinase, C-terminal; Phosphoenolpyruvate carboxykinase, GTP-utilising; Phosphoenolpyruvate carboxykinase, GTP-utilising, conserved site; Phosphoenolpyruvate carboxykinase, N-terminal. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of moderate expression. Peak expression observed at stages throughout embryogenesis, at stages throughout the larval period, at stages throughout the pupal period, in stages of adults of both sexes. Summary of FlyAtlas Anatomical Expression Data: Many larval and adult organs/tissues expressed at high levels. Expression at high levels in the following post-embryonic organs or tissues: adult head, adult eye, larval midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, larval salivary gland, larval trachea, adult spermathecae, larval/adult carcass. Expression at moderate levels in the following post-embryonic organs or tissues: adult thoracico-abdominal ganglion, adult crop, adult midgut, adult male reproductive system. Comments on Affy2 ProbeSet: ProbeSet 1633599_a_at completely aligns to an exonic region common to each of the 2 FlyBase-annotated transcript isoforms of Pepck. Gene sequence location is 2R:14424272..14426924.
Phenotypic Description from the Red Book (Lindsley & Zimm 1992)
Gene/Allele symbols may differ from current usage	Pepck: Phosphoenolpyruvate-carboxykinase Structural gene for the enzyme phosphoenolpyruvate-carboxykinase in Drosophila melanogaster.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2011_10	References Maruyama et al., 2011, PLoS ONE 6(6): e20901
FB2012_01	Sequence features HFA07505 BKN40725
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 55D3-55D3   Limits computationally determined from genome sequence between P{lacW}l(2)08770k04808 and P{EP}EP437
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\Pepck for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	5' UTR contains an ORF described as a putative conserved uORF (FBrf0204849); potential peptide 27aa in length.
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Pepck-RA FBtr0086701  NM_079060   2489   647 Pepck-RB FBtr0086700  NM_166293   2653   500
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Pepck-PA   FBpp0085880   71.1   647   6.45     NP_523784   AAF57676 Pepck-PB   FBpp0085879   54.9   500   7.04     NP_725802   AAM68462
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Phosphoenolpyruvate carboxykinase, GTP-utilising, conserved site (IPR018091) Phosphoenolpyruvate carboxykinase, C-terminal (IPR013035) Phosphoenolpyruvate carboxykinase, GTP-utilising (IPR008209) Phosphoenolpyruvate carboxykinase, N-terminal (IPR008210) MitoDrome - A database of annotated Dmel nuclear genes encoding mitochondrial proteins • MTDROME17725
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA201798   AA203077   AA263897   AA391070   AA567790   AA697966   AA698136   AA698793   AA698885   AA698933   AA699043   AA941807   AA951329   AE013599 AAF57676   AE013599 AAM68462   AI062289   AI062310   AI062488   AI062519   AI062856   AI062893   AI063060   AI063318   AI063353   AI063359   AI063386   AI063420   AI063617   AI063708   AI064008   AI064383   AI064632   AI106670   AI107145   AI107270   AI107830   AI107959   AI108422   AI108450   AI108571   AI109128   AI109285   AI109743   AI110138   AI113552   AI113644   AI113645   AI113852   AI113907   AI114383   AI133916   AI134710   AI134766   AI135490   AI135520   AI238058   AI238174   AI238198   AI238267   AI238472   AI238720   AI239084   AI256998   AI257215   AI257615   AI258029   AI258069   AI258087   AI258173   AI258216   AI258340   AI258350   AI258413   AI258451   AI258731   AI258734   AI259051   AI259299   AI259418   AI259550   AI259792   AI260055   AI260056   AI260333   AI260636   AI260638   AI260838   AI292622   AI292692   AI293191   AI293575   AI293888   AI294119   AI294317   AI294547   AI294557   AI294597   AI294635   AI295191   AI295595   AI295756   AI295782   AI296035   AI296592   AI296996   AI297209   AI297497   AI297632   AI386716   AI386753   AI386971   AI387024   AI387170   AI387209   AI387237   AI387828   AI387949   AI388194   AI388387   AI388483   AI388722   AI388979   AI389037   AI389056   AI389164   AI389210   AI389304   AI389337   AI389358   AI389368   AI390052   AI402414   AI402501   AI402515   AI402896   AI403055   AI403162   AI403238   AI403397   AI403447   AI403833   AI403842   AI403942   AI403994   AI404584   AI404623   AI404690   AI405081   AI405908   AI455671   AI513572   AI513668   AI513976   AI514047   AI514247   AI514560   AI516563   AI516979   AI517402   AI517472   AI517590   AI517599   AI517705   AI517721   AI519926   AI531944   AI532737   AI541899   AI542916   AI946386   AY439795   BF493942   BF494065   BF494400   BF495003   BF502399   BF504097   BG632555   BI166803   BI171571   BI173462   BI173644   BI212531   BI215675   BI227485   BI227634   BI227973   BI229571   BI230250   BI231719   BI231920   BI234535   BI236797   BI239205   BI239904   BI240878   BI240962   BI242673   BI357314   BI361793   BI362238   BI363157   BI368578   BI375030   BI486343   BI486521   BI563458   BI564243   BI565147   BI565384   BI565441   BI565755   BI568430   BI571250   BI571684   BI571783   BI571984   BI572079   BI572154   BI572170   BI572356   BI572525   BI572788   BI573156   BI575839   BI575869   BI576418   BI577626   BI582115   BI582126   BI582233   BI582290   BI582559   BI582831   BI583550   BI585455   BI585572   BI586096   BI586217   BI587502   BI587852   BI590119   BI590288   BI590403   BI590604   BI590622   BI590726   BI590834   BI591015   BI591025   BI591197   BI591198   BI591536   BI592253   BI592279   BI592680   BI593251   BI604892   BI604979   BI605122   BI605599   BI606163   BI606315   BI606822   BI606986   BI607027   BI607073   BI607407   BI607417   BI607581   BI607795   BI608178   BI608604   BI609305   BI612261   BI612354   BI612778   BI612824   BI613722   BI615025   BI615221   BI617101   BI617154   BI618554   BI619060   BI619084   BI619140   BI619194   BI619351   BI619357   BI619548   BI619730   BI619818   BI619860   BI620041   BI620253   BI620437   BI620660   BI620763   BI621337   BI621759   BI621855   BI622649   BI622857   BI622987   BI623768   BI623888   BI624007   BI624342   BI624576   BI625517   BI625580   BI625640   BI627630   BI628011   BI628269   BI628766   BI628791   BI628801   BI629289   BI629373   BI629847   BI630599   BI630617   BI630642   BI630678   BI631419   BI631473   BI633827   BI634099   BI634778   BI635270   BI635325   BI636172   BI636771   BI637921   BI639020   BI641541   BI641562   BT003447 AAO39450   CK131633   CK132040   CK657037   CK657149   CK657549   CK657694   CK657801   CK658087   CK658109   CK658352   CK658620   CK658822   CK658910   CK659304   CK659346   CK659758   CK659842   CK660079   CK660480   CK660633   CK661226   CK661230   CK661804   CK661876   CK661912   CK662351   CO153925   CO182634   CO185161   CO192951   CO276130   CO279709   CO284262   CO302670   CO303247   CO308193   CO315476   EC054577   EC057355   EC059887   EC059978   EC060766   EC062167   EC082899   EC202709   EC206681   EC226024   EC228705   EC234841   EC238160   EC255356   EL870853   EL872588   EL872713   EL879449   EL879571   EL886818   ES690014   ES690018   ES690020   ES690031   ES690033   ES690061   ES692112   ES692113   ES692114   ES692115   ES692116   ES692117   ES692118   ES692119   ES692121   ES692763   EV592628   GH783602   GH788711   GH792703   GH799393   GH822509   GH825991   GH827952   GH876866   GH883769   GH892256   GH942599   Y00402 CAA68463
UniProtKB/Swiss-Prot	P20007
UniProtKB/TrEMBL
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
northern blot Stage Tissue/Position (including subcellular localization) Reference first instar larval stage   organism | late   (Zinke et al., 1999) second instar larval stage     (Zinke et al., 1999)
Additional Descriptive Data
	Transcript can be detected from 40 to 70 hours after egg laying in larval extracts. (Zinke et al., 1999)
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0003067    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0003067 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of moderate expression. Peak expression observed at stages throughout embryogenesis, at stages throughout the larval period, at stages throughout the pupal period, in stages of adults of both sexes. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0003067 expression level Developmental Stage   Expression Level embryo 00-02hr    474 embryo 02-04hr    4044 embryo 04-06hr    10252 embryo 06-08hr    17878 embryo 08-10hr    15954 embryo 10-12hr    7496 embryo 12-14hr    5878 embryo 14-16hr    12254 embryo 16-18hr    21128 embryo 18-20hr    39173 embryo 20-22hr    21826 embryo 22-24hr    26134 larva L1    17792 larva L2    15713 larva L3 12hr old    25837 larva L3 puffstage 1-2    25121 larva L3 puffstage 3-6    30293 larva L3 puffstage 7-9    26940 white prepupae new    43483 white prepupae 12hr    40504 white prepupae 24hr    40932 pupae 2d postWPP    29419 pupae 3d postWPP    17286 pupae 4d postWPP    23974 adult male 01day    23805 adult male 05day    23239 adult male 30day    19891 adult female 01day    16614 adult female 05day    9756 adult female 30day    10637 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (474) embryo 02-04hr  (4044) embryo 04-06hr  (10252) embryo 06-08hr  (17878) embryo 08-10hr  (15954) embryo 10-12hr  (7496) embryo 12-14hr  (5878) embryo 14-16hr  (12254) embryo 16-18hr  (21128) embryo 18-20hr  (39173) embryo 20-22hr  (21826) embryo 22-24hr  (26134) larva L1  (17792) larva L2  (15713) larva L3 12hr old  (25837) larva L3 puffstage 1-2  (25121) larva L3 puffstage 3-6  (30293) larva L3 puffstage 7-9  (26940) white prepupae new  (43483) white prepupae 12hr  (40504) white prepupae 24hr  (40932) pupae 2d postWPP  (29419) pupae 3d postWPP  (17286) pupae 4d postWPP  (23974) adult male 01day  (23805) adult male 05day  (23239) adult male 30day  (19891) adult female 01day  (16614) adult female 05day  (9756) adult female 30day  (10637) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    474 embryo 02-04hr  (4044) embryo 04-06hr  (10252) embryo 06-08hr  (17878) embryo 08-10hr  (15954) embryo 10-12hr  (7496) embryo 12-14hr  (5878) embryo 14-16hr  (12254) embryo 16-18hr  (21128) embryo 18-20hr  (39173) embryo 20-22hr  (21826) embryo 22-24hr  (26134) larva L1  (17792) larva L2  (15713) larva L3 12hr old  (25837) larva L3 puffstage 1-2  (25121) larva L3 puffstage 3-6  (30293) larva L3 puffstage 7-9  (26940) white prepupae new  (43483) white prepupae 12hr  (40504) white prepupae 24hr  (40932) pupae 2d postWPP  (29419) pupae 3d postWPP  (17286) pupae 4d postWPP  (23974) adult male 01day  (23805) adult male 05day  (23239) adult male 30day  (19891) adult female 01day  (16614) adult female 05day  (9756) adult female 30day  (10637) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    474 embryo 02-04hr    4044 embryo 04-06hr  10252 embryo 06-08hr  (17878) embryo 08-10hr  (15954) embryo 10-12hr    7496 embryo 12-14hr    5878 embryo 14-16hr  (12254) embryo 16-18hr  (21128) embryo 18-20hr  (39173) embryo 20-22hr  (21826) embryo 22-24hr  (26134) larva L1  (17792) larva L2  (15713) larva L3 12hr old  (25837) larva L3 puffstage 1-2  (25121) larva L3 puffstage 3-6  (30293) larva L3 puffstage 7-9  (26940) white prepupae new  (43483) white prepupae 12hr  (40504) white prepupae 24hr  (40932) pupae 2d postWPP  (29419) pupae 3d postWPP  (17286) pupae 4d postWPP  (23974) adult male 01day  (23805) adult male 05day  (23239) adult male 30day  (19891) adult female 01day  (16614) adult female 05day    9756 adult female 30day  10637 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    474 embryo 02-04hr    4044 embryo 04-06hr    10252 embryo 06-08hr    17878 embryo 08-10hr    15954 embryo 10-12hr    7496 embryo 12-14hr    5878 embryo 14-16hr    12254 embryo 16-18hr    21128 embryo 18-20hr    39173 embryo 20-22hr    21826 embryo 22-24hr    26134 larva L1    17792 larva L2    15713 larva L3 12hr old    25837 larva L3 puffstage 1-2    25121 larva L3 puffstage 3-6    30293 larva L3 puffstage 7-9    26940 white prepupae new    43483 white prepupae 12hr    40504 white prepupae 24hr    40932 pupae 2d postWPP    29419 pupae 3d postWPP    17286 pupae 4d postWPP    23974 adult male 01day    23805 adult male 05day    23239 adult male 30day    19891 adult female 01day    16614 adult female 05day    9756 adult female 30day    10637 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0003067 expression level Developmental Stage   Expression Level embryo 00-02hr    474 embryo 02-04hr    4044 embryo 04-06hr    10252 embryo 06-08hr    17878 embryo 08-10hr    15954 embryo 10-12hr    7496 embryo 12-14hr    5878 embryo 14-16hr    12254 embryo 16-18hr    21128 embryo 18-20hr    39173 embryo 20-22hr    21826 embryo 22-24hr    26134 larva L1    17792 larva L2    15713 larva L3 12hr old    25837 larva L3 puffstage 1-2    25121 larva L3 puffstage 3-6    30293 larva L3 puffstage 7-9    26940 white prepupae new    43483 white prepupae 12hr    40504 white prepupae 24hr    40932 pupae 2d postWPP    29419 pupae 3d postWPP    17286 pupae 4d postWPP    23974 adult male 01day    23805 adult male 05day    23239 adult male 30day    19891 adult female 01day    16614 adult female 05day    9756 adult female 30day    10637 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (474) embryo 02-04hr  (4044) embryo 04-06hr  (10252) embryo 06-08hr  (17878) embryo 08-10hr  (15954) embryo 10-12hr  (7496) embryo 12-14hr  (5878) embryo 14-16hr  (12254) embryo 16-18hr  (21128) embryo 18-20hr  (39173) embryo 20-22hr  (21826) embryo 22-24hr  (26134) larva L1  (17792) larva L2  (15713) larva L3 12hr old  (25837) larva L3 puffstage 1-2  (25121) larva L3 puffstage 3-6  (30293) larva L3 puffstage 7-9  (26940) white prepupae new  (43483) white prepupae 12hr  (40504) white prepupae 24hr  (40932) pupae 2d postWPP  (29419) pupae 3d postWPP  (17286) pupae 4d postWPP  (23974) adult male 01day  (23805) adult male 05day  (23239) adult male 30day  (19891) adult female 01day  (16614) adult female 05day  (9756) adult female 30day  (10637) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    474 embryo 02-04hr  (4044) embryo 04-06hr  (10252) embryo 06-08hr  (17878) embryo 08-10hr  (15954) embryo 10-12hr  (7496) embryo 12-14hr  (5878) embryo 14-16hr  (12254) embryo 16-18hr  (21128) embryo 18-20hr  (39173) embryo 20-22hr  (21826) embryo 22-24hr  (26134) larva L1  (17792) larva L2  (15713) larva L3 12hr old  (25837) larva L3 puffstage 1-2  (25121) larva L3 puffstage 3-6  (30293) larva L3 puffstage 7-9  (26940) white prepupae new  (43483) white prepupae 12hr  (40504) white prepupae 24hr  (40932) pupae 2d postWPP  (29419) pupae 3d postWPP  (17286) pupae 4d postWPP  (23974) adult male 01day  (23805) adult male 05day  (23239) adult male 30day  (19891) adult female 01day  (16614) adult female 05day  (9756) adult female 30day  (10637) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    474 embryo 02-04hr    4044 embryo 04-06hr  10252 embryo 06-08hr  17878 embryo 08-10hr  15954 embryo 10-12hr    7496 embryo 12-14hr    5878 embryo 14-16hr  12254 embryo 16-18hr  (21128) embryo 18-20hr  (39173) embryo 20-22hr  (21826) embryo 22-24hr  (26134) larva L1  17792 larva L2  15713 larva L3 12hr old  (25837) larva L3 puffstage 1-2  (25121) larva L3 puffstage 3-6  (30293) larva L3 puffstage 7-9  (26940) white prepupae new  (43483) white prepupae 12hr  (40504) white prepupae 24hr  (40932) pupae 2d postWPP  (29419) pupae 3d postWPP  17286 pupae 4d postWPP  (23974) adult male 01day  (23805) adult male 05day  (23239) adult male 30day  19891 adult female 01day  16614 adult female 05day    9756 adult female 30day  10637 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    474 embryo 02-04hr    4044 embryo 04-06hr    10252 embryo 06-08hr    17878 embryo 08-10hr    15954 embryo 10-12hr    7496 embryo 12-14hr    5878 embryo 14-16hr    12254 embryo 16-18hr    21128 embryo 18-20hr    39173 embryo 20-22hr    21826 embryo 22-24hr    26134 larva L1    17792 larva L2    15713 larva L3 12hr old    25837 larva L3 puffstage 1-2    25121 larva L3 puffstage 3-6    30293 larva L3 puffstage 7-9    26940 white prepupae new    43483 white prepupae 12hr    40504 white prepupae 24hr    40932 pupae 2d postWPP    29419 pupae 3d postWPP    17286 pupae 4d postWPP    23974 adult male 01day    23805 adult male 05day    23239 adult male 30day    19891 adult female 01day    16614 adult female 05day    9756 adult female 30day    10637 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0003067    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0003067 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Many larval and adult organs/tissues expressed at high levels. Expression at high levels in the following post-embryonic organs or tissues: adult head, adult eye, larval midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, larval salivary gland, larval trachea, adult spermathecae, larval/adult carcass. Expression at moderate levels in the following post-embryonic organs or tissues: adult thoracico-abdominal ganglion, adult crop, adult midgut, adult male reproductive system. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0003067 expression level Tissue   Expression Level Larval Central Nervous System    73.575 Larval Midgut    4100.9 Larval Hindgut    2843.2 Larval Malpighian Tubules    3283.6 Larval Fat Body    6230.6 Larval Salivary Gland    1258 Larval Trachea    534.175 Larval Carcass    3431.325 Adult Head    3367.4 Adult Eye    1871.2 Adult Brain    74.5 Adult Thoracic-Abdominal Ganglion    177.7 Adult Crop    142.9 Adult Midgut    418.3 Adult Hindgut    1209.8 Adult Malpighian Tubules    3432.1 Adult Fat Body    5386.7 Adult Salivary Gland no informative data Adult Heart    5375.325 Adult VirginFemale Spermatheca    5203.7 Adult InseminatedFemale Spermatheca    5294.5 Adult Ovary    39.3 Adult Testis    123.3 Adult Male Accessory Gland    276.9 Adult Carcass    5580.8 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    73.575 Larval Midgut  (4100.9) Larval Hindgut  (2843.2) Larval Malpighian Tubules  (3283.6) Larval Fat Body  (6230.6) Larval Salivary Gland  (1258) Larval Trachea  534.175 Larval Carcass  (3431.325) Adult Head  (3367.4) Adult Eye  (1871.2) Adult Brain    74.5 Adult Thoracic-Abdominal Ganglion    177.7 Adult Crop    142.9 Adult Midgut    418.3 Adult Hindgut  (1209.8) Adult Malpighian Tubules  (3432.1) Adult Fat Body  (5386.7) Adult Salivary Gland no informative data Adult Heart  (5375.325) Adult VirginFemale Spermatheca  (5203.7) Adult InseminatedFemale Spermatheca  (5294.5) Adult Ovary    39.3 Adult Testis    123.3 Adult Male Accessory Gland    276.9 Adult Carcass  (5580.8) Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    73.575 Larval Midgut  (4100.9) Larval Hindgut  (2843.2) Larval Malpighian Tubules  (3283.6) Larval Fat Body  (6230.6) Larval Salivary Gland  (1258) Larval Trachea    534.175 Larval Carcass  (3431.325) Adult Head  (3367.4) Adult Eye  (1871.2) Adult Brain    74.5 Adult Thoracic-Abdominal Ganglion    177.7 Adult Crop    142.9 Adult Midgut    418.3 Adult Hindgut  (1209.8) Adult Malpighian Tubules  (3432.1) Adult Fat Body  (5386.7) Adult Salivary Gland no informative data Adult Heart  (5375.325) Adult VirginFemale Spermatheca  (5203.7) Adult InseminatedFemale Spermatheca  (5294.5) Adult Ovary    39.3 Adult Testis    123.3 Adult Male Accessory Gland    276.9 Adult Carcass  (5580.8) Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    73.575 Larval Midgut    4100.9 Larval Hindgut    2843.2 Larval Malpighian Tubules    3283.6 Larval Fat Body    6230.6 Larval Salivary Gland    1258 Larval Trachea    534.175 Larval Carcass    3431.325 Adult Head    3367.4 Adult Eye    1871.2 Adult Brain    74.5 Adult Thoracic-Abdominal Ganglion    177.7 Adult Crop    142.9 Adult Midgut    418.3 Adult Hindgut    1209.8 Adult Malpighian Tubules    3432.1 Adult Fat Body    5386.7 Adult Salivary Gland no informative data Adult Heart    5375.325 Adult VirginFemale Spermatheca    5203.7 Adult InseminatedFemale Spermatheca    5294.5 Adult Ovary    39.3 Adult Testis    123.3 Adult Male Accessory Gland    276.9 Adult Carcass    5580.8 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0003067 expression level Tissue   Expression Level Larval Central Nervous System    73.575 Larval Midgut    4100.9 Larval Hindgut    2843.2 Larval Malpighian Tubules    3283.6 Larval Fat Body    6230.6 Larval Salivary Gland    1258 Larval Trachea    534.175 Larval Carcass    3431.325 Adult Head    3367.4 Adult Eye    1871.2 Adult Brain    74.5 Adult Thoracic-Abdominal Ganglion    177.7 Adult Crop    142.9 Adult Midgut    418.3 Adult Hindgut    1209.8 Adult Malpighian Tubules    3432.1 Adult Fat Body    5386.7 Adult Salivary Gland no informative data Adult Heart    5375.325 Adult VirginFemale Spermatheca    5203.7 Adult InseminatedFemale Spermatheca    5294.5 Adult Ovary    39.3 Adult Testis    123.3 Adult Male Accessory Gland    276.9 Adult Carcass    5580.8 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    73.575 Larval Midgut  (4100.9) Larval Hindgut  (2843.2) Larval Malpighian Tubules  (3283.6) Larval Fat Body  (6230.6) Larval Salivary Gland  (1258) Larval Trachea  534.175 Larval Carcass  (3431.325) Adult Head  (3367.4) Adult Eye  (1871.2) Adult Brain    74.5 Adult Thoracic-Abdominal Ganglion    177.7 Adult Crop    142.9 Adult Midgut    418.3 Adult Hindgut  (1209.8) Adult Malpighian Tubules  (3432.1) Adult Fat Body  (5386.7) Adult Salivary Gland no informative data Adult Heart  (5375.325) Adult VirginFemale Spermatheca  (5203.7) Adult InseminatedFemale Spermatheca  (5294.5) Adult Ovary    39.3 Adult Testis    123.3 Adult Male Accessory Gland    276.9 Adult Carcass  (5580.8) Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    73.575 Larval Midgut  (4100.9) Larval Hindgut  (2843.2) Larval Malpighian Tubules  (3283.6) Larval Fat Body  (6230.6) Larval Salivary Gland  1258 Larval Trachea    534.175 Larval Carcass  (3431.325) Adult Head  (3367.4) Adult Eye  (1871.2) Adult Brain    74.5 Adult Thoracic-Abdominal Ganglion    177.7 Adult Crop    142.9 Adult Midgut    418.3 Adult Hindgut  1209.8 Adult Malpighian Tubules  (3432.1) Adult Fat Body  (5386.7) Adult Salivary Gland no informative data Adult Heart  (5375.325) Adult VirginFemale Spermatheca  (5203.7) Adult InseminatedFemale Spermatheca  (5294.5) Adult Ovary    39.3 Adult Testis    123.3 Adult Male Accessory Gland    276.9 Adult Carcass  (5580.8) Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    73.575 Larval Midgut    4100.9 Larval Hindgut    2843.2 Larval Malpighian Tubules    3283.6 Larval Fat Body    6230.6 Larval Salivary Gland    1258 Larval Trachea    534.175 Larval Carcass    3431.325 Adult Head    3367.4 Adult Eye    1871.2 Adult Brain    74.5 Adult Thoracic-Abdominal Ganglion    177.7 Adult Crop    142.9 Adult Midgut    418.3 Adult Hindgut    1209.8 Adult Malpighian Tubules    3432.1 Adult Fat Body    5386.7 Adult Salivary Gland no informative data Adult Heart    5375.325 Adult VirginFemale Spermatheca    5203.7 Adult InseminatedFemale Spermatheca    5294.5 Adult Ovary    39.3 Adult Testis    123.3 Adult Male Accessory Gland    276.9 Adult Carcass    5580.8 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland no informative data Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    3367.4   NA  Eye    1871.2   NA  Brain    74.5   73.575  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    177.7   NA  Crop    142.9   4100.9  Midgut    418.3   2843.2  Hindgut    1209.8   3283.6  Malpighian Tubules    3432.1   6230.6  Fat Body    5386.7   1258  Salivary Gland    no informative data   NA  Heart    5375.325   534.175  Trachea    NA   NA  VirginFemale Spermatheca    5203.7   NA  InseminatedFemale Spermatheca    5294.5   NA  Ovary    39.3   NA  Testis    123.3   NA  Male Accessory Gland    276.9   3431.325  Carcass    5580.8 modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_25
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0003067 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG17725-RB FlyExpress - Embryonic expression images (BDGP data) • Show all FlyExpress processed images for Pepck Stages(s) 4-6 Stages(s) 7-8 Stages(s) 9-10 Stages(s) 11-12 Stages(s) 13-16
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele viable, with Scer\GAL4pnr-MD237 PepckGD9451 Phenotype manifest in Allele
Classical Alleles ( 1 )
For All Classical Alleles Show
Allele of Pepck Class Mutagen Stocks Known lesion PepckMI00026 1 --
Alleles Carried on Transgenic Constructs ( 2 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Pepck Class Mutagen Stocks Known lesion PepckGD16827 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes PepckGD9451 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes
Aneuploid Aberrations
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD9451} NA P{GD16827} NA
Insertions
	Type of insertions Name Expression data miscellaneous insertions Mi{MIC}PepckMI00026 NA P{GT1}BG02569 NA insertion of enhancer trap P{lacW}l(2)SH1344SH1344 No insertion of mobile activating element P{EP}EP2388 NA
Gene Ontology: Function, Process & Cellular Component ( 4 unique terms )
Terms Based on Experimental Evidence ( 0 terms )
Terms Based on Predictions or Assertions ( 4 terms )
Molecular Function
CV term Evidence References
GTP binding inferred from electronic annotation with InterPro:IPR008209 (FlyBase Curators et al., 2004-) phosphoenolpyruvate carboxykinase (GTP) activity inferred from sequence or structural similarity with UniProtKB:P05153 (FlyBase, 1992-) inferred from sequence or structural similarity with UniProtKB:Q16822 (Sardiello et al., 2003.6.11)
Biological Process
CV term Evidence References
gluconeogenesis inferred from sequence or structural similarity with UniProtKB:Q16822 (Sardiello et al., 2003.6.11) non-traceable author statement (Swiss-Prot Project Members, 1991.2.1)
Cellular Component
CV term Evidence References
mitochondrion inferred from sequence or structural similarity with UniProtKB:Q16822 (Sardiello et al., 2003.6.11)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Pepck allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 62806 DroID - A comprehensive database of gene and protein interactions. • FBgn0003067 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 37131
Orthologs
Genome-wide drosophilid orthologs	Dana\GF11971 Dere\GG21904 Dgri\GH22963 Dmoj\GI18450 Dpse\GA14628 Dsec\GM21895 Dsim\GD11392 Dvir\GJ21535 Dwil\GK17957 Dyak\GE11980
Curated drosophilid orthologs	Dpse\GA14628
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL000006-PA Aedes aegypti (mosquito) AGAP003350-PA Anopheles gambiae (mosquito) XP_001949386.1 Acyrthosiphon pisum (pea aphid) 68589 Branchiostoma floridae (lancelet) XP_001896498.1 Brugia malayi (roundworm nematode) CBP00083 Caenorhabditis briggsae (nematode) ENSCAFP00000017488 Canis familiaris (dog) ENSCINP00000012511 Ciona intestinalis (sea squirt) JA18494 Caenorhabditis japonica (nematode) CPIJ010515 Culex pipens (mosquito) ENSCPOP00000005929 Cavia porcellus (guinea pig) ENSCPOP00000009803 Cavia porcellus (guinea pig) ENSCSAVP00000009425 Ciona savignyi (sedentary tunicate) 160685 Capitella spl (polychaete worm) DDB0230145 Dictyostelium discoideum (amoeba) ENSDARP00000018261 Danio rerio (zebra fish) ENSECAP00000011966 Equus caballus (horse) ENSGACP00000004885 Gymnopilus aculeatus (mushroom) ENSGALP00000012342 Gallus gallus (chicken) 109161 Hypsipyla robusta (cedar shoot borer) ENSP00000216780 Homo sapiens (human) ISCW001902-PA Ixodes scapularis (deer tick) ENSMODP00000020614 Monodelphis domestica (gray opossum) ENSMMUP00000028436 Macaca mulatta (rhesus monkey) XP_001600227.1 Nasonia vitripennis (wasp) ENSOANP00000012548 Ornithorynchus anatinus (platypus) ENSORLP00000016033 Oryzias latipes (japanese killifish) PHUM001532-PA Pediculus humanus (human body louse) ENSPPYP00000006459 Pongo pygmaeus (orangutan) ENSPPYP00000012471 Pongo pygmaeus (orangutan) ENSPTRP00000010507 Pan troglodytes (chimpanzee) Smp_005880 Schistosoma mansoni (trematode parasite) 49773 Trichoplax adhaerens (metazoa) XP_975997.1 Tribolium castaneum (red flour beetle) ENSTNIP00000020630 Tetraodon nigroviridis (green spotted pufferfish) ENSTRUP00000020541 Takifugu rubripes (pufferfish Takifugu) 84943.m00198 Trichomonas vaginalis (parasitic flagellated protozoan) 87399.m00118 Trichomonas vaginalis (parasitic flagellated protozoan) 94782.m00165 Trichomonas vaginalis (parasitic flagellated protozoan) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB12676 PB10905 NV17655 LH13186 LH13182 ISCW001902 ISCW000524 FBgn0229758 FBgn0229757 FBgn0219956 FBgn0219955 FBgn0208655 FBgn0208654 FBgn0183141 FBgn0183140 FBgn0176772 FBgn0176771 JGI_V11_314004 JGI_V11_212175 FBgn0074655 FBgn0070703 FBgn0154687 FBgn0154686 FBgn0141188 FBgn0141189 FBgn0034356 FBgn0130420 FBgn0130418 FBgn0114082 FBgn0114081 FBgn0089010 FBgn0089009 CPIJ010518 CPIJ010515 CPIJ010516 BGIBMGA004276 BGIBMGA004277 ACYPI001978 GB16196 AGAP003350 AAEL000080 AAEL000025 AAEL000006 PHUM368600 GLEAN_09072
Stocks & Reagents
Stocks Listed in FlyBase ( 4 )
Bloomington	30599 y1 w*; Mi{MIC}PepckMI00026
VDRC	v20529 w1118; P{GD9451}v20529 v50253 w1118; P{GD16827}v50253 v50252 w1118; P{GD16827}v50252/TM3
Genomic Clones ( 1 )
	BACR27L09 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 406 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	RH57538
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	AT02332 AT02476 AT02877 AT03810 AT05385 AT18107 GH01443 GH01467 GH01711 GH01743 GH02207 GH02486 GH02845 GH03105 GH03160 GH03530 GH04777 GH05687 GH06457 GH07252 GH07284 GH08235 GH08427 GH09032 GH09617 GH09888 GH10042 GH10336 GH10415 GH10529 GH12313 GH13277 GH13317 GH14209 GH14820 GH15262 GH15652 GH16892 GH16955 GH17369 GH17436 GH17666 GH18492 GH18656 GH19283 GH20045 GH20115 GH20138 GH20267 GH20443 GH20507 GH20518 GH21632 GH21750 GH22418 GH22546 GH22884 GH23357 GH23493 GH24349 GH24407 GH24488 GH24994 GH26717 GH27096 GH27335 GH27593 GH28331 GH28624 GH28755 GH28773 HL01774 HL03540 HL03830 HL05862 HL05972 LD03725 LD09996 LD39776 LP01111 LP01181 LP01352 LP01505 LP01519 LP01656 LP01993 LP02001 LP02374 LP02985 LP03285 LP03733 LP04131 LP04263 LP04570 LP04573 LP04825 LP06028 LP07142 LP07656 LP07948 LP07960 LP11137 LP11466 LP11971 LP13251 LP14682 LP15220 LP15687 LP16972 LP17738 LP17921 LP18331 LP19092 LP21646 LP22480 LP23225 SD03258 SD04337 SD07858 SD09433 SD16569 SD16637 SD17765 SD18586 SD20086 SD21451 SD24914 SD24946 SD27993
Other clones	28174 46419 60278 107330 120692 153302 214287.54 bs24g08 CK01.21B.A12 CK01.44A.D10 CK01.116D.G6 CK01.141A.E1 CK01.145C.G5 CK01.145D.C12 Dmel_neb_010159_0611_0343 EC23461 EC29761 EC34886 EC054577 EK119744 EK135716 EK165621 EK184653 EK240652 EK256948 EK261601 EN03116 GH02260 GH03059 GH03111 GH03218 GH03669 GH04250 GH05866 GH06612 GH06742 GH07761 GH10041 GH10960 GH11238 GH12245 GH14042 GH14175 GH14282 GH14520 GH15566 GH16308 GH17622 GH17706 GH19013 GH19419 GH19711 GH20329 GH20478 GH21514 GH21736 GH22226 GH22637 GH22825 GH23368 GH23559 GH26061 GH26705 GH27010 GH28432 GH28611 HL05703 HL07352 IP02951 IP04487 IP04587 IP09420 IP09520 IP18030 LD03575 LD07114 LD26017 LD31739 LD35309 LD41110 LD42464 LP01159 LP01304 LP01612 LP02680 LP02829 LP03732 LP05520 LP06745 LP07424 LP08011 LP08052 LP08750 LP09269 LP09480 LP09515 LP09827 LP10550 LP11806 LP12537 LP14644 LP16071 LP16213 LP17055 LP19368 LP20480 LP20488 LP21537 LP21718 LP22990 LP23940 LP24190 LP24380 RC0-DA0004-130700-011-F10 RE07025 RE08925 RE13378 RE16393 RE16713 RE17636 RE22258 RE23340 RE24543 RE24738 RE25102 RE25366 RE27378 RE30250 RE32916 RE35635 RE36516 RE37828 RE37931 RE40070 RE43765 RE46156 RE46749 RE47907 RE54570 RE62741 RE69763 RE69960 RE71336 RH03694 RH03884 RH04024 RH04247 RH04266 RH04385 RH04514 RH04718 RH04728 RH04929 RH04930 RH06087 RH06253 RH06955 RH07072 RH07316 RH07419 RH07505 RH07524 RH07848 RH08063 RH08426 RH08872 RH09895 RH09926 RH10439 RH11237 RH11734 RH12358 RH13176 RH14067 RH20035 RH20048 RH20192 RH20258 RH20805 RH21247 RH22183 RH25040 RH25180 RH25844 RH26072 RH28190 RH28744 RH32162 RH32211 RH32973 RH34093 RH36116 RH37312 RH39011 RH39875 RH40680 RH40789 RH41743 RH41807 RH42943 RH44541 RH44801 RH47333 RH47392 RH49416 RH50025 RH50054 RH50117 RH50175 RH50371 RH50378 RH50605 RH50825 RH50936 RH50985 RH51202 RH51338 RH51583 RH51853 RH51975 RH52662 RH53160 RH53276 RH54555 RH54784 RH55040 RH56108 RH56247 RH56379 RH56630 RH57510 RH57549 RH58132 RH58229 RH58770 RH59872 RH59893 RH59924 RH59961 RH60987 RH61052 RH62838 RH63148 RH63217 RH63569 RH63885 RH64158 RH65962 RH66036 RH66107 RH68987 RH69535 RH70387 RH70487 RH70653 RH71421 RH72371 RH72629 RH73657 RH73958 RH74007 RH74063 RH74471 RH74482 RH74673 RP003255249 RP003304043 RP003324209 RP003349847 RP003353548 RP003452887 RP003470778 RP003521300 RP003599351 RP003618454 RP003663690
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0003067 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 37131
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of
Additional comments
Other Comments
	Transcriptionally downregulated after 2h of insulin stimulation in Kc167 cells. Contains fkh response elements (FHREs) in the genomic upstream or intronic sequences. (Junger et al., 2003) Comparison of CpG distribution in the coding region of 121 genes from six species supports the mCpG mutational hotspot explanation of CpG suppression in methylated species at position II-III and III-I. (Schorderet and Gartler, 1992) Structural gene for the enzyme phosphoenolpyruvate-carboxykinase.
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_079060 NM_166293 RefSeq (Proteins) • NP_523784 NP_725802 DDBJ / EMBL / GenBank • AAF57676 AAM68462 AAO39450 AI294597 AI946386 BI628791 BT003447 CAA68463 Y00402 Entrez Gene - A searchable database of RefSeq genes. • 37131 UniProtKB/Swiss-Prot • P20007
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Phosphoenolpyruvate carboxykinase, GTP-utilising, conserved site (IPR018091) Phosphoenolpyruvate carboxykinase, C-terminal (IPR013035) Phosphoenolpyruvate carboxykinase, GTP-utilising (IPR008209) Phosphoenolpyruvate carboxykinase, N-terminal (IPR008210) MitoDrome - A database of annotated Dmel nuclear genes encoding mitochondrial proteins • MTDROME17725
Linkouts
	BioGRID - A database of protein and genetic interactions • 62806 DroID - A comprehensive database of gene and protein interactions. • FBgn0003067 DRSC - Results from RNAi screens. • FBgn0003067 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0003067 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG17725-RB FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0003067 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 37131 InParanoid A subset of ortholog calls from InParanoid. • AAEL000006-PA Aedes aegypti (mosquito) AGAP003350-PA Anopheles gambiae (mosquito) XP_001949386.1 Acyrthosiphon pisum (pea aphid) 68589 Branchiostoma floridae (lancelet) XP_001896498.1 Brugia malayi (roundworm nematode) CBP00083 Caenorhabditis briggsae (nematode) ENSCAFP00000017488 Canis familiaris (dog) ENSCINP00000012511 Ciona intestinalis (sea squirt) JA18494 Caenorhabditis japonica (nematode) CPIJ010515 Culex pipens (mosquito) ENSCPOP00000005929 Cavia porcellus (guinea pig) ENSCPOP00000009803 Cavia porcellus (guinea pig) ENSCSAVP00000009425 Ciona savignyi (sedentary tunicate) 160685 Capitella spl (polychaete worm) DDB0230145 Dictyostelium discoideum (amoeba) ENSDARP00000018261 Danio rerio (zebra fish) ENSECAP00000011966 Equus caballus (horse) ENSGACP00000004885 Gymnopilus aculeatus (mushroom) ENSGALP00000012342 Gallus gallus (chicken) 109161 Hypsipyla robusta (cedar shoot borer) ENSP00000216780 Homo sapiens (human) ISCW001902-PA Ixodes scapularis (deer tick) ENSMODP00000020614 Monodelphis domestica (gray opossum) ENSMMUP00000028436 Macaca mulatta (rhesus monkey) XP_001600227.1 Nasonia vitripennis (wasp) ENSOANP00000012548 Ornithorynchus anatinus (platypus) ENSORLP00000016033 Oryzias latipes (japanese killifish) PHUM001532-PA Pediculus humanus (human body louse) ENSPPYP00000006459 Pongo pygmaeus (orangutan) ENSPPYP00000012471 Pongo pygmaeus (orangutan) ENSPTRP00000010507 Pan troglodytes (chimpanzee) Smp_005880 Schistosoma mansoni (trematode parasite) 49773 Trichoplax adhaerens (metazoa) XP_975997.1 Tribolium castaneum (red flour beetle) ENSTNIP00000020630 Tetraodon nigroviridis (green spotted pufferfish) ENSTRUP00000020541 Takifugu rubripes (pufferfish Takifugu) 84943.m00198 Trichomonas vaginalis (parasitic flagellated protozoan) 87399.m00118 Trichomonas vaginalis (parasitic flagellated protozoan) 94782.m00165 Trichomonas vaginalis (parasitic flagellated protozoan) InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 37131 modMine - Data generated by the modENCODE project. • FBgn0003067 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB12676 PB10905 NV17655 LH13186 LH13182 ISCW001902 ISCW000524 FBgn0229758 FBgn0229757 FBgn0219956 FBgn0219955 FBgn0208655 FBgn0208654 FBgn0183141 FBgn0183140 FBgn0176772 FBgn0176771 JGI_V11_314004 JGI_V11_212175 FBgn0074655 FBgn0070703 FBgn0154687 FBgn0154686 FBgn0141188 FBgn0141189 FBgn0034356 FBgn0130420 FBgn0130418 FBgn0114082 FBgn0114081 FBgn0089010 FBgn0089009 CPIJ010518 CPIJ010515 CPIJ010516 BGIBMGA004276 BGIBMGA004277 ACYPI001978 GB16196 AGAP003350 AAEL000080 AAEL000025 AAEL000006 PHUM368600 GLEAN_09072
Synonyms & Secondary IDs ( 13 )
Reported As
Symbol Synonym	143299_at (Kristensen et al., 2005) CG10924 (Fernández-Ayala et al., 2010) CG17725 (Pile et al., 2003, Sun et al., 2010, Li et al., 2009, Hayden and Bosco, 2008, Fujikawa et al., 2009, Riedl et al., 2005) dPEPCK (Okamura et al., 2007) Dromel_CG17725_FBtr0086701_pepck_mORF (Hayden and Bosco, 2008) Pepck (Maruyama et al., 2011, Sun et al., 2010, Lindsley and Zimm, 1992, Li et al., 2009, Bartkuhn et al., 2009, Hayden and Bosco, 2008, Liu and Lehmann, 2008, Fujikawa et al., 2009, Haussmann et al., 2008, Fernández-Ayala et al., 2010, Shim et al., 2009, Cherbas et al., 2011, Haussmann and Soller, 2010, Riedl et al., 2005) PEPCK (Teleman et al., 2005, Boyd et al., 2011) pepck (Poels et al., 2004, Hull-Thompson et al., 2009, Beckstead et al., 2007)
Name Synonym	Phosphoenolpyruvate carboxykinase (Hayden and Bosco, 2008, Riedl et al., 2005) Phosphoenolpyruvate-carboxykinase (Lindsley and Zimm, 1992) phosphoenolpyruvate carboxykinase (Poels et al., 2004, Hull-Thompson et al., 2009, Boyd et al., 2011) phosphoenolpyruvate carboxy kinase (Harvey et al., 2008) phosphoenol pyruvate carboxykinase (Owusu-Ansah and Banerjee, 2009)
Secondary FlyBase IDs
References ( 50 )
Generate a list of	All references relating to this gene ( 50 )
List References by type	Research paper  ( 31 ) Supplementary material  ( 5 ) Personal communication to FlyBase  ( 5 ) FlyBase analysis  ( 1 ) Book  ( 1 ) Protein sequence record  ( 1 ) Computer file  ( 2 ) Curated genome annotation  ( 1 ) Automatic genome annotation  ( 1 ) Letter  ( 1 )
Recent research papers ( 7 )
	Boyd et al., 2011, Free Radical Biol. Med. 50(11): 1669--1678 Nectarine promotes longevity in Drosophila melanogaster. [FBrf0213612] Cherbas et al., 2011, Genome Res. 21(2): 301--314 The transcriptional diversity of 25 Drosophila cell lines. [FBrf0213077] Maruyama et al., 2011, PLoS ONE 6(6): e20901 Genome-Wide Analysis Reveals a Major Role in Cell Fate Maintenance and an Unexpected Role in Endoreduplication for the Drosophila FoxA Gene Fork Head. [FBrf0214025] Fernández-Ayala et al., 2010, PLoS ONE 5(1): e8549 Gene expression in a Drosophila model of mitochondrial disease. [FBrf0209705] Haussmann and Soller, 2010, Dev. Biol. 348(2): 224--230 Differential activity of EWG transcription factor isoforms identifies a subset of differentially regulated genes important for synaptic growth regulation. [FBrf0212261] Sun et al., 2010, Exp. Gerontol. 45(3): 243--251 Açai palm fruit (Euterpe oleracea Mart.) pulp improves survival of flies on a high fat diet. [FBrf0210041] Willis et al., 2010, J. Insect Sci. 10: 66 Microarray Analysis of Juvenile Hormone Response in Drosophila melanogaster S2 cells. [FBrf0211402] Show all research papers ...