• Home
• Tools
  • Tools Overview
  • Query Tools

    
    • QuickSearch
    • QueryBuilder
    • TermLink
    • CytoSearch
    • RNA-Seq Search
    • Interactions Browser
    • ImageBrowse
    • Find A Person
    • Google™ FlyBase
  • Genomic/Map Tools

    
    • BLAST
    • GBrowse
    • GBrowse 2 Beta
    • CytoSearch
    • Feature Mapper
    • Aberrations Maps
    • Chromosome Maps
    • Coordinates Converter
  • Retrieve/Convert

    
    • Batch Download
    • Coordinates Converter
    • ID Converter
  • Data Submission

    
    • Fast-Track Your Paper
    • Submit Personal Comm
    • Add A New Person
    • Update Person Info
  • People

    
    • Find A Person
    • Add A New Person
    • Update Person Info
• Files
  • Files Overview
  • Current release
  • Archived releases
  • Map Conversion
  • FTP site:
  • Releases (FTP)
  • Genomes (FTP)
• Species
  • Phylogeny
  • Sequenced Species
  • Synteny Table
  • Color Illustrations
  • Abbreviations
• Documents
  • About FlyBase
  • Reference Manual:
  • Sections
  • Contents
  • Nomenclature
  • Release Notes
• Resources
  • All Resources
  • Model Organisms
  • Stock Collections
  • Vectors & Constructs
  • Other links:
  • BDGP
  • DGRC
  • DIS by issue
  • FlyExpress
  • Interactive Fly
  • modENCODE
  • Textpresso for Fly
• News
  • News
  • FlyBase Forum
  • FlyBase Positions
  • Meetings
  • Courses
  • Fly Board
  • White papers
  • Funding
  • bionet.dros
• Help
  • Google™ FlyBase
  • Site Map
  • FAQs
  • FlyBase Guides
  • Video Tutorials
  • Report help
  • New to Flies
  • Pers. comm.
  • Author guidelines
  • Contact FlyBase
• Archives
  • Prior Release
  • Other Archives
  • Coordinate Converter

Gene Dmel\Pgi

General Information
Symbol	Dmel\Pgi	Species	D. melanogaster
Name	Phosphoglucose isomerase	Annotation symbol	CG8251
Feature type	protein_coding_gene	FlyBase ID	FBgn0003074
Gene Model Status	Current	Stock availability	11 publicly available
Also Known As	GPI
Genomic Location
Chromosome (arm)	2R	Recombination map
Cytogenetic map	44F6-44F6	Sequence location	2R:4,798,405..4,801,574 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Phosphoglucose isomerase is referred to in FlyBase by the symbol Dmel\Pgi (CG8251, FBgn0003074). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: glucose-6-phosphate isomerase activity. It is reported to be involved in the biological process: gluconeogenesis; glycolysis. 22 alleles are reported. No phenotypic data is available. It has 3 annotated transcripts and 3 annotated polypeptides. Protein features are: Phosphoglucose isomerase (PGI); Phosphoglucose isomerase, C-terminal; Phosphoglucose isomerase, conserved site. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of moderately high expression. Peak expression observed within 18-24 hour embryonic stages, at stages throughout the larval period, during late pupal stages, in stages of adults of both sexes. Summary of FlyAtlas Anatomical Expression Data: High or moderate levels of expression observed in all larval and adult organs/tissues. Expression at high levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, larval/adult salivary gland, larval trachea, adult female reproductive system, adult testis, larval/adult carcass. Expression at moderate levels in the following post-embryonic organs or tissues: adult male accessory gland. Comments on Affy2 ProbeSet: ProbeSet 1638550_s_at completely aligns to an exonic region common to each of the 3 FlyBase-annotated transcript isoforms of Pgi. Gene sequence location is 2R:4798405..4801574.
User Contributed Data
	Beta version, feedback welcome
Phenotypic Description from the Red Book (Lindsley & Zimm 1992)
Gene/Allele symbols may differ from current usage	Pgi: Phosphoglucose isomerase Structural gene for the glycolytic enzyme phosphoglucose isomerase [PGI (E.C. 5.3.1.9)]. There are two electrophoretic variants (fast and slow); also a deficiency for the locus which is CRM negative and probably homozygous lethal (Lee, 1979).
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 44F6-44F6   Limits computationally determined from genome sequence between P{lacW}Dmnk16109&P{lacW}Gγ1k08017 and P{lacW}babok16912
Experimentally Determined Cytological Location
Cytogenetic map Notes References 44F9-45A2   (determined by in situ hybridisation)   (BDGP Project Members, 1994-1999)
Experimentally Determined Recombination Data
Location	2-58.6 (Voelker et al., 1980) 1- (Choudhary et al., 1992) 2-58.0 (Clark et al., 1995)
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\Pgi for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Low-frequency RNA-Seq exon junction(s) not annotated. Gene model reviewed during 5.49
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Pgi-RA FBtr0088679  NM_078939   2460   558 Pgi-RB FBtr0088680  NM_165635   2321   558 Pgi-RC FBtr0088681  NM_165636   2277   558
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Pgi-PA   FBpp0087760   62.3   558   7.13     NP_523663   AAF59025 Pgi-PB   FBpp0087761   62.3   558   7.13     NP_724723   AAM71090 Pgi-PC   FBpp0087762   62.3   558   7.13     NP_724724   AAM71091
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Phosphoglucose isomerase, conserved site (IPR018189) Phosphoglucose isomerase (PGI) (IPR001672) Phosphoglucose isomerase, C-terminal (IPR023096)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA246722   AA390725   AA540966   AA567366   AA567443   AA567623   AA694732   AA695648   AA697585   AA698597   AA699083   AA803554   AA948979   AA949549   AE013599 AAF59025   AE013599 AAM71090   AE013599 AAM71091   AC006074   AI062335   AI064382   AI064459   AI106966   AI107402   AI107753   AI108059   AI108655   AI114182   AI114247   AI114248   AI135394   AI135724   AI239144   AI239149   AI259520   AI260335   AI293328   AI294795   AI296388   AI296893   AI387039   AI389807   AI402345   AI402660   AI404250   AI404469   AI405266   AI405942   AI513259   AI517015   AI530864   AI532300   AI945190   AI946073   AI946932   AY051468 AAK92892   BE976608   BE977785   BF485971   BF486161   BF488397   BF488683   BF492895   BF492896   BF494574   BF496076   BF496404   BF496969   BF498381   BF498390   BF498631   BF501750   BF503047   BF503853   BF504204   BF506107   BF506620   BG633915   BG634204   BG634338   BG635588   BG640698   BI162845   BI165507   BI167353   BI167508   BI213418   BI229910   BI232003   BI236831   BI241973   BI242389   BI361457   BI366637   BI369299   BI370160   BI482470   BI483196   BI484581   BI484808   BI563562   BI564284   BI564852   BI565889   BI566056   BI566915   BI566922   BI567162   BI567437   BI568254   BI568483   BI569904   BI570585   BI572511   BI572815   BI572818   BI573097   BI574890   BI574897   BI575040   BI575233   BI575301   BI575451   BI575781   BI575812   BI576923   BI576929   BI578178   BI580217   BI582953   BI583088   BI583119   BI583122   BI584128   BI585241   BI586278   BI587850   BI587902   BI588489   BI588809   BI589212   BI589259   BI589350   BI590120   BI590539   BI590724   BI590879   BI591199   BI591257   BI591268   BI591273   BI591512   BI591646   BI592436   BI604332   BI604820   BI605347   BI605486   BI605549   BI605738   BI606116   BI606923   BI607301   BI610841   BI610862   BI613362   BI614100   BI614379   BI615908   BI615986   BI617994   BI620260   BI621433   BI621591   BI624565   BI625893   BI626173   BI626289   BI627027   BI627210   BI627225   BI627671   BI629556   BI629578   BI630777   BI630915   BI631008   BI633612   BI634494   BI636913   BI640839   BI640918   BQ103516   BQ103743   CK657651   CK659587   CK659878   CK662259   CL526137   CO185112   CO195612   CO277416   CO287400   CO314468   CO322383   CO322684   CO324633   CO332080   CZ472764   EC060272   EC063068   EC086020   EC090590   EC200878   EC223166   EC239534   EC263358   EL872853   EL876557   EL876558   EL876778   EL876779   EL876886   EL876887   EL880988   ES688833   ES688839   ES689650   ES691471   ES691986   ES693554   ES693556   ES693580   ES693588   ES693623   ES693635   ES693638   ES693639   ES694132   ES694149   ES694164   ES694168   ES694172   ES694174   ES694176   ES694180   ES694191   ES694193   ES694672   ES694673   ES694674   ES694678   ES694680   ES694682   ES694684   ES694685   ES694686   ES694692   ES694693   ES694694   ES694696   ES694697   ES694699   ES694700   ES694702   ES694707   ES694708   ES694711   ES694712   ES694713   ES694716   ES694719   ES694721   ES694722   ES694726   ES694729   ES694732   ES694733   ES694734   ES694736   ES694737   ES694741   ES694742   ES694744   ES694745   ES694746   ES694747   ES694749   ES694751   ES694754   ES694755   ES694757   ES694760   ES694768   ES695205   ES695206   ES695208   ES695210   ES695211   ES695216   ES695222   ES695223   EV580284   EV587857   EV589067   EV597979   EV599066   EV599476   GH941613   GH942973   GH943685   GH945389   GH951182   GH951291   GH952840   GH955680   GH955715   GH955795   GH956951   GH957408   GH959326   GH959832   GH961031   GH965227   GH966053   GH966131   GH967200   GH967658   GH967817   GH969331   GH971135   GH972548   GH973897   GH974978   GH975414   GH975728   GH975872   GH977732   GH980430   GH980495   GH981227   GH984083   L27539 AAA28789   L27540 AAA28790   L27541 AAA28791   L27542 AAA28792   L27543 AAA28793   L27544 AAA28794   L27545 AAA28795   L27546 AAA28796   L27553 AAA28803   L27554 AAA28804   L27555 AAA28805   U20566 AAA63671   U20567 AAA63672   U20568 AAA63673   U20569 AAA63674   U20570 AAA63675   U20571 AAA63676   U20572 AAA63677   U20573 AAA63678   U20574 AAA63679   U20575 AAA63680   Z50557
UniProtKB/Swiss-Prot	P52029
UniProtKB/TrEMBL
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage 1 -- 3   organism   (Fisher et al., 2012) Comment:maternally deposited embryonic stage 4 -- 6   organism | ubiquitous   (Fisher et al., 2012) embryonic stage 7 -- 8   organism | ubiquitous   (Fisher et al., 2012) embryonic stage 9 -- 10   organism | ubiquitous   (Fisher et al., 2012) embryonic stage 11 -- 12   organism | ubiquitous   (Fisher et al., 2012) embryonic stage 13 -- 16   dorsal pharyngeal muscle   (Fisher et al., 2012) embryonic/larval muscle system   (Fisher et al., 2012) embryonic/larval somatic muscle   (Fisher et al., 2012)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
mass spectroscopy Stage Tissue/Position (including subcellular localization) Reference day 5 of adulthood & male -- day 7 of adulthood & male   spermatozoon   (Dorus et al., 2006, Wasbrough et al., 2010) day 7 of adulthood -- day 49 of adulthood   adult heart   (Cammarato et al., 2011)
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
lipid particle inferred from direct assay (Beller et al., 2006)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: High or moderate levels of expression observed in all larval and adult organs/tissues. Expression at high levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, larval/adult salivary gland, larval trachea, adult female reproductive system, adult testis, larval/adult carcass. Expression at moderate levels in the following post-embryonic organs or tissues: adult male accessory gland. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    1405.7 Larval Midgut    517.6 Larval Hindgut    697.5 Larval Malpighian Tubules    824.7 Larval Fat Body    1620.4 Larval Salivary Gland    1367.4 Larval Trachea    649.425 Larval Carcass    3817.525 Adult Head    1737.7 Adult Eye    1227.425 Adult Brain    1150.9 Adult Thoracic-Abdominal Ganglion    1244.6 Adult Crop    2315 Adult Midgut    1200.2 Adult Hindgut    2419.3 Adult Malpighian Tubules    3287.1 Adult Fat Body    2778.5 Adult Salivary Gland    4189.1 Adult Heart    2112.675 Adult VirginFemale Spermatheca    4077.6 Adult InseminatedFemale Spermatheca    3391.3 Adult Ovary    866.2 Adult Testis    748.8 Adult Male Accessory Gland    445.7 Adult Carcass    2963.1 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System  (1405.7) Larval Midgut  517.6 Larval Hindgut  (697.5) Larval Malpighian Tubules  (824.7) Larval Fat Body  (1620.4) Larval Salivary Gland  (1367.4) Larval Trachea  (649.425) Larval Carcass  (3817.525) Adult Head  (1737.7) Adult Eye  (1227.425) Adult Brain  (1150.9) Adult Thoracic-Abdominal Ganglion  (1244.6) Adult Crop  (2315) Adult Midgut  (1200.2) Adult Hindgut  (2419.3) Adult Malpighian Tubules  (3287.1) Adult Fat Body  (2778.5) Adult Salivary Gland  (4189.1) Adult Heart  (2112.675) Adult VirginFemale Spermatheca  (4077.6) Adult InseminatedFemale Spermatheca  (3391.3) Adult Ovary  (866.2) Adult Testis  (748.8) Adult Male Accessory Gland    445.7 Adult Carcass  (2963.1) Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System  (1405.7) Larval Midgut    517.6 Larval Hindgut    697.5 Larval Malpighian Tubules    824.7 Larval Fat Body  (1620.4) Larval Salivary Gland  (1367.4) Larval Trachea    649.425 Larval Carcass  (3817.525) Adult Head  (1737.7) Adult Eye  (1227.425) Adult Brain  (1150.9) Adult Thoracic-Abdominal Ganglion  (1244.6) Adult Crop  (2315) Adult Midgut  (1200.2) Adult Hindgut  (2419.3) Adult Malpighian Tubules  (3287.1) Adult Fat Body  (2778.5) Adult Salivary Gland  (4189.1) Adult Heart  (2112.675) Adult VirginFemale Spermatheca  (4077.6) Adult InseminatedFemale Spermatheca  (3391.3) Adult Ovary    866.2 Adult Testis    748.8 Adult Male Accessory Gland    445.7 Adult Carcass  (2963.1) Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    1405.7 Larval Midgut    517.6 Larval Hindgut    697.5 Larval Malpighian Tubules    824.7 Larval Fat Body    1620.4 Larval Salivary Gland    1367.4 Larval Trachea    649.425 Larval Carcass    3817.525 Adult Head    1737.7 Adult Eye    1227.425 Adult Brain    1150.9 Adult Thoracic-Abdominal Ganglion    1244.6 Adult Crop    2315 Adult Midgut    1200.2 Adult Hindgut    2419.3 Adult Malpighian Tubules    3287.1 Adult Fat Body    2778.5 Adult Salivary Gland    4189.1 Adult Heart    2112.675 Adult VirginFemale Spermatheca    4077.6 Adult InseminatedFemale Spermatheca    3391.3 Adult Ovary    866.2 Adult Testis    748.8 Adult Male Accessory Gland    445.7 Adult Carcass    2963.1 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    1405.7 Larval Midgut    517.6 Larval Hindgut    697.5 Larval Malpighian Tubules    824.7 Larval Fat Body    1620.4 Larval Salivary Gland    1367.4 Larval Trachea    649.425 Larval Carcass    3817.525 Adult Head    1737.7 Adult Eye    1227.425 Adult Brain    1150.9 Adult Thoracic-Abdominal Ganglion    1244.6 Adult Crop    2315 Adult Midgut    1200.2 Adult Hindgut    2419.3 Adult Malpighian Tubules    3287.1 Adult Fat Body    2778.5 Adult Salivary Gland    4189.1 Adult Heart    2112.675 Adult VirginFemale Spermatheca    4077.6 Adult InseminatedFemale Spermatheca    3391.3 Adult Ovary    866.2 Adult Testis    748.8 Adult Male Accessory Gland    445.7 Adult Carcass    2963.1 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System  (1405.7) Larval Midgut  517.6 Larval Hindgut  697.5 Larval Malpighian Tubules  (824.7) Larval Fat Body  (1620.4) Larval Salivary Gland  (1367.4) Larval Trachea  649.425 Larval Carcass  (3817.525) Adult Head  (1737.7) Adult Eye  (1227.425) Adult Brain  (1150.9) Adult Thoracic-Abdominal Ganglion  (1244.6) Adult Crop  (2315) Adult Midgut  (1200.2) Adult Hindgut  (2419.3) Adult Malpighian Tubules  (3287.1) Adult Fat Body  (2778.5) Adult Salivary Gland  (4189.1) Adult Heart  (2112.675) Adult VirginFemale Spermatheca  (4077.6) Adult InseminatedFemale Spermatheca  (3391.3) Adult Ovary  (866.2) Adult Testis  748.8 Adult Male Accessory Gland    445.7 Adult Carcass  (2963.1) Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System  1405.7 Larval Midgut    517.6 Larval Hindgut    697.5 Larval Malpighian Tubules    824.7 Larval Fat Body  1620.4 Larval Salivary Gland  1367.4 Larval Trachea    649.425 Larval Carcass  (3817.525) Adult Head  (1737.7) Adult Eye  1227.425 Adult Brain  1150.9 Adult Thoracic-Abdominal Ganglion  1244.6 Adult Crop  (2315) Adult Midgut  1200.2 Adult Hindgut  (2419.3) Adult Malpighian Tubules  (3287.1) Adult Fat Body  (2778.5) Adult Salivary Gland  (4189.1) Adult Heart  (2112.675) Adult VirginFemale Spermatheca  (4077.6) Adult InseminatedFemale Spermatheca  (3391.3) Adult Ovary    866.2 Adult Testis    748.8 Adult Male Accessory Gland    445.7 Adult Carcass  (2963.1) Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    1405.7 Larval Midgut    517.6 Larval Hindgut    697.5 Larval Malpighian Tubules    824.7 Larval Fat Body    1620.4 Larval Salivary Gland    1367.4 Larval Trachea    649.425 Larval Carcass    3817.525 Adult Head    1737.7 Adult Eye    1227.425 Adult Brain    1150.9 Adult Thoracic-Abdominal Ganglion    1244.6 Adult Crop    2315 Adult Midgut    1200.2 Adult Hindgut    2419.3 Adult Malpighian Tubules    3287.1 Adult Fat Body    2778.5 Adult Salivary Gland    4189.1 Adult Heart    2112.675 Adult VirginFemale Spermatheca    4077.6 Adult InseminatedFemale Spermatheca    3391.3 Adult Ovary    866.2 Adult Testis    748.8 Adult Male Accessory Gland    445.7 Adult Carcass    2963.1 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    1737.7   NA  Eye    1227.425   NA  Brain    1150.9   1405.7  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    1244.6   NA  Crop    2315   517.6  Midgut    1200.2   697.5  Hindgut    2419.3   824.7  Malpighian Tubules    3287.1   1620.4  Fat Body    2778.5   1367.4  Salivary Gland    4189.1   NA  Heart    2112.675   649.425  Trachea    NA   NA  VirginFemale Spermatheca    4077.6   NA  InseminatedFemale Spermatheca    3391.3   NA  Ovary    866.2   NA  Testis    748.8   NA  Male Accessory Gland    445.7   3817.525  Carcass    2963.1 FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    114 central nervous system, larvae L3    50 central nervous system, pupae P8    31 head, virgin 1-day female    216 head, virgin 4-day female    135 head, virgin 20-day female    200 head, mated 1-day female    153 head, mated 4-day female    102 head, mated 20-day female    176 head, mated 1-day male    189 head, mated 4-day male    215 head, mated 20-day male    279 salivary gland, larvae L3 wandering    13 salivary gland, white prepupae    17 digestive system, larvae L3 wandering    20 digestive system, 1-day adult    110 digestive system, 4-day adult    90 digestive system, 20-day adult    101 fat body, larvae L3 wandering    136 fat body, white prepupae    87 fat body, pupae P8    53 carcass, larvae L3 wandering    111 carcass, 1-day adult    375 carcass, 4-day adult    186 carcass, 20-day adult    191 ovary, virgin 4-day female    148 ovary, mated 4-day female    110 testis, mated 4-day male    281 accessory gland, mated 4-day male    52 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (114) central nervous system, larvae L3  (50) central nervous system, pupae P8  (31) head, virgin 1-day female  (216) head, virgin 4-day female  (135) head, virgin 20-day female  (200) head, mated 1-day female  (153) head, mated 4-day female  (102) head, mated 20-day female  (176) head, mated 1-day male  (189) head, mated 4-day male  (215) head, mated 20-day male  (279) salivary gland, larvae L3 wandering    13 salivary gland, white prepupae    17 digestive system, larvae L3 wandering    20 digestive system, 1-day adult  (110) digestive system, 4-day adult  (90) digestive system, 20-day adult  (101) fat body, larvae L3 wandering  (136) fat body, white prepupae  (87) fat body, pupae P8  (53) carcass, larvae L3 wandering  (111) carcass, 1-day adult  (375) carcass, 4-day adult  (186) carcass, 20-day adult  (191) ovary, virgin 4-day female  (148) ovary, mated 4-day female  (110) testis, mated 4-day male  (281) accessory gland, mated 4-day male  (52) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (114) central nervous system, larvae L3    50 central nervous system, pupae P8    31 head, virgin 1-day female  (216) head, virgin 4-day female  (135) head, virgin 20-day female  (200) head, mated 1-day female  (153) head, mated 4-day female  102 head, mated 20-day female  (176) head, mated 1-day male  (189) head, mated 4-day male  (215) head, mated 20-day male  (279) salivary gland, larvae L3 wandering    13 salivary gland, white prepupae    17 digestive system, larvae L3 wandering    20 digestive system, 1-day adult  (110) digestive system, 4-day adult    90 digestive system, 20-day adult  101 fat body, larvae L3 wandering  (136) fat body, white prepupae    87 fat body, pupae P8    53 carcass, larvae L3 wandering  (111) carcass, 1-day adult  (375) carcass, 4-day adult  (186) carcass, 20-day adult  (191) ovary, virgin 4-day female  (148) ovary, mated 4-day female  (110) testis, mated 4-day male  (281) accessory gland, mated 4-day male    52 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    114 central nervous system, larvae L3    50 central nervous system, pupae P8    31 head, virgin 1-day female    216 head, virgin 4-day female    135 head, virgin 20-day female    200 head, mated 1-day female    153 head, mated 4-day female    102 head, mated 20-day female    176 head, mated 1-day male    189 head, mated 4-day male    215 head, mated 20-day male    279 salivary gland, larvae L3 wandering    13 salivary gland, white prepupae    17 digestive system, larvae L3 wandering    20 digestive system, 1-day adult    110 digestive system, 4-day adult    90 digestive system, 20-day adult    101 fat body, larvae L3 wandering    136 fat body, white prepupae    87 fat body, pupae P8    53 carcass, larvae L3 wandering    111 carcass, 1-day adult    375 carcass, 4-day adult    186 carcass, 20-day adult    191 ovary, virgin 4-day female    148 ovary, mated 4-day female    110 testis, mated 4-day male    281 accessory gland, mated 4-day male    52 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    114 central nervous system, larvae L3    50 central nervous system, pupae P8    31 head, virgin 1-day female    216 head, virgin 4-day female    135 head, virgin 20-day female    200 head, mated 1-day female    153 head, mated 4-day female    102 head, mated 20-day female    176 head, mated 1-day male    189 head, mated 4-day male    215 head, mated 20-day male    279 salivary gland, larvae L3 wandering    13 salivary gland, white prepupae    17 digestive system, larvae L3 wandering    20 digestive system, 1-day adult    110 digestive system, 4-day adult    90 digestive system, 20-day adult    101 fat body, larvae L3 wandering    136 fat body, white prepupae    87 fat body, pupae P8    53 carcass, larvae L3 wandering    111 carcass, 1-day adult    375 carcass, 4-day adult    186 carcass, 20-day adult    191 ovary, virgin 4-day female    148 ovary, mated 4-day female    110 testis, mated 4-day male    281 accessory gland, mated 4-day male    52 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (114) central nervous system, larvae L3  (50) central nervous system, pupae P8  31 head, virgin 1-day female  (216) head, virgin 4-day female  (135) head, virgin 20-day female  (200) head, mated 1-day female  (153) head, mated 4-day female  (102) head, mated 20-day female  (176) head, mated 1-day male  (189) head, mated 4-day male  (215) head, mated 20-day male  (279) salivary gland, larvae L3 wandering    13 salivary gland, white prepupae    17 digestive system, larvae L3 wandering    20 digestive system, 1-day adult  (110) digestive system, 4-day adult  (90) digestive system, 20-day adult  (101) fat body, larvae L3 wandering  (136) fat body, white prepupae  (87) fat body, pupae P8  (53) carcass, larvae L3 wandering  (111) carcass, 1-day adult  (375) carcass, 4-day adult  (186) carcass, 20-day adult  (191) ovary, virgin 4-day female  (148) ovary, mated 4-day female  (110) testis, mated 4-day male  (281) accessory gland, mated 4-day male  (52) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering  114 central nervous system, larvae L3    50 central nervous system, pupae P8    31 head, virgin 1-day female  (216) head, virgin 4-day female  135 head, virgin 20-day female  (200) head, mated 1-day female  (153) head, mated 4-day female  102 head, mated 20-day female  (176) head, mated 1-day male  (189) head, mated 4-day male  (215) head, mated 20-day male  (279) salivary gland, larvae L3 wandering    13 salivary gland, white prepupae    17 digestive system, larvae L3 wandering    20 digestive system, 1-day adult  110 digestive system, 4-day adult    90 digestive system, 20-day adult  101 fat body, larvae L3 wandering  136 fat body, white prepupae    87 fat body, pupae P8    53 carcass, larvae L3 wandering  111 carcass, 1-day adult  (375) carcass, 4-day adult  (186) carcass, 20-day adult  (191) ovary, virgin 4-day female  (148) ovary, mated 4-day female  110 testis, mated 4-day male  (281) accessory gland, mated 4-day male    52 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    114 central nervous system, larvae L3    50 central nervous system, pupae P8    31 head, virgin 1-day female    216 head, virgin 4-day female    135 head, virgin 20-day female    200 head, mated 1-day female    153 head, mated 4-day female    102 head, mated 20-day female    176 head, mated 1-day male    189 head, mated 4-day male    215 head, mated 20-day male    279 salivary gland, larvae L3 wandering    13 salivary gland, white prepupae    17 digestive system, larvae L3 wandering    20 digestive system, 1-day adult    110 digestive system, 4-day adult    90 digestive system, 20-day adult    101 fat body, larvae L3 wandering    136 fat body, white prepupae    87 fat body, pupae P8    53 carcass, larvae L3 wandering    111 carcass, 1-day adult    375 carcass, 4-day adult    186 carcass, 20-day adult    191 ovary, virgin 4-day female    148 ovary, mated 4-day female    110 testis, mated 4-day male    281 accessory gland, mated 4-day male    52 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of moderately high expression. Peak expression observed within 18-24 hour embryonic stages, at stages throughout the larval period, during late pupal stages, in stages of adults of both sexes. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    127 embryo 02-04hr    21 embryo 04-06hr    45 embryo 06-08hr    28 embryo 08-10hr    22 embryo 10-12hr    30 embryo 12-14hr    29 embryo 14-16hr    62 embryo 16-18hr    63 embryo 18-20hr    112 embryo 20-22hr    257 embryo 22-24hr    259 larva L1    288 larva L2    262 larva L3 12hr old    342 larva L3 puffstage 1-2    318 larva L3 puffstage 3-6    198 larva L3 puffstage 7-9    94 white prepupae new    100 white prepupae 12hr    83 white prepupae 24hr    72 pupae 2d postWPP    163 pupae 3d postWPP    217 pupae 4d postWPP    381 adult male 01day    444 adult male 05day    358 adult male 30day    269 adult female 01day    312 adult female 05day    172 adult female 30day    151 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (127) embryo 02-04hr    21 embryo 04-06hr  (45) embryo 06-08hr  (28) embryo 08-10hr    22 embryo 10-12hr  (30) embryo 12-14hr  (29) embryo 14-16hr  (62) embryo 16-18hr  (63) embryo 18-20hr  (112) embryo 20-22hr  (257) embryo 22-24hr  (259) larva L1  (288) larva L2  (262) larva L3 12hr old  (342) larva L3 puffstage 1-2  (318) larva L3 puffstage 3-6  (198) larva L3 puffstage 7-9  (94) white prepupae new  (100) white prepupae 12hr  (83) white prepupae 24hr  (72) pupae 2d postWPP  (163) pupae 3d postWPP  (217) pupae 4d postWPP  (381) adult male 01day  (444) adult male 05day  (358) adult male 30day  (269) adult female 01day  (312) adult female 05day  (172) adult female 30day  (151) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr  (127) embryo 02-04hr    21 embryo 04-06hr    45 embryo 06-08hr    28 embryo 08-10hr    22 embryo 10-12hr    30 embryo 12-14hr    29 embryo 14-16hr    62 embryo 16-18hr    63 embryo 18-20hr  (112) embryo 20-22hr  (257) embryo 22-24hr  (259) larva L1  (288) larva L2  (262) larva L3 12hr old  (342) larva L3 puffstage 1-2  (318) larva L3 puffstage 3-6  (198) larva L3 puffstage 7-9    94 white prepupae new    100 white prepupae 12hr    83 white prepupae 24hr    72 pupae 2d postWPP  (163) pupae 3d postWPP  (217) pupae 4d postWPP  (381) adult male 01day  (444) adult male 05day  (358) adult male 30day  (269) adult female 01day  (312) adult female 05day  (172) adult female 30day  (151) Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    127 embryo 02-04hr    21 embryo 04-06hr    45 embryo 06-08hr    28 embryo 08-10hr    22 embryo 10-12hr    30 embryo 12-14hr    29 embryo 14-16hr    62 embryo 16-18hr    63 embryo 18-20hr    112 embryo 20-22hr    257 embryo 22-24hr    259 larva L1    288 larva L2    262 larva L3 12hr old    342 larva L3 puffstage 1-2    318 larva L3 puffstage 3-6    198 larva L3 puffstage 7-9    94 white prepupae new    100 white prepupae 12hr    83 white prepupae 24hr    72 pupae 2d postWPP    163 pupae 3d postWPP    217 pupae 4d postWPP    381 adult male 01day    444 adult male 05day    358 adult male 30day    269 adult female 01day    312 adult female 05day    172 adult female 30day    151 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    127 embryo 02-04hr    21 embryo 04-06hr    45 embryo 06-08hr    28 embryo 08-10hr    22 embryo 10-12hr    30 embryo 12-14hr    29 embryo 14-16hr    62 embryo 16-18hr    63 embryo 18-20hr    112 embryo 20-22hr    257 embryo 22-24hr    259 larva L1    288 larva L2    262 larva L3 12hr old    342 larva L3 puffstage 1-2    318 larva L3 puffstage 3-6    198 larva L3 puffstage 7-9    94 white prepupae new    100 white prepupae 12hr    83 white prepupae 24hr    72 pupae 2d postWPP    163 pupae 3d postWPP    217 pupae 4d postWPP    381 adult male 01day    444 adult male 05day    358 adult male 30day    269 adult female 01day    312 adult female 05day    172 adult female 30day    151 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (127) embryo 02-04hr    21 embryo 04-06hr  (45) embryo 06-08hr  28 embryo 08-10hr    22 embryo 10-12hr  30 embryo 12-14hr  29 embryo 14-16hr  (62) embryo 16-18hr  (63) embryo 18-20hr  (112) embryo 20-22hr  (257) embryo 22-24hr  (259) larva L1  (288) larva L2  (262) larva L3 12hr old  (342) larva L3 puffstage 1-2  (318) larva L3 puffstage 3-6  (198) larva L3 puffstage 7-9  (94) white prepupae new  (100) white prepupae 12hr  (83) white prepupae 24hr  (72) pupae 2d postWPP  (163) pupae 3d postWPP  (217) pupae 4d postWPP  (381) adult male 01day  (444) adult male 05day  (358) adult male 30day  (269) adult female 01day  (312) adult female 05day  (172) adult female 30day  (151) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr  127 embryo 02-04hr    21 embryo 04-06hr    45 embryo 06-08hr    28 embryo 08-10hr    22 embryo 10-12hr    30 embryo 12-14hr    29 embryo 14-16hr    62 embryo 16-18hr    63 embryo 18-20hr  112 embryo 20-22hr  (257) embryo 22-24hr  (259) larva L1  (288) larva L2  (262) larva L3 12hr old  (342) larva L3 puffstage 1-2  (318) larva L3 puffstage 3-6  (198) larva L3 puffstage 7-9    94 white prepupae new    100 white prepupae 12hr    83 white prepupae 24hr    72 pupae 2d postWPP  (163) pupae 3d postWPP  (217) pupae 4d postWPP  (381) adult male 01day  (444) adult male 05day  (358) adult male 30day  (269) adult female 01day  (312) adult female 05day  (172) adult female 30day  (151) Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    127 embryo 02-04hr    21 embryo 04-06hr    45 embryo 06-08hr    28 embryo 08-10hr    22 embryo 10-12hr    30 embryo 12-14hr    29 embryo 14-16hr    62 embryo 16-18hr    63 embryo 18-20hr    112 embryo 20-22hr    257 embryo 22-24hr    259 larva L1    288 larva L2    262 larva L3 12hr old    342 larva L3 puffstage 1-2    318 larva L3 puffstage 3-6    198 larva L3 puffstage 7-9    94 white prepupae new    100 white prepupae 12hr    83 white prepupae 24hr    72 pupae 2d postWPP    163 pupae 3d postWPP    217 pupae 4d postWPP    381 adult male 01day    444 adult male 05day    358 adult male 30day    269 adult female 01day    312 adult female 05day    172 adult female 30day    151 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    55 Schneider line 2 Sg4    53 embryonic 1182-4H    47 embryonic GM2    104 embryonic Kc167    101 embryonic S1    157 embryonic S3    72 leg disc CME L1    81 wing disc CME-W2    72 wing disc ML-DmD8    109 wing disc ML-DmD9    107 wing disc ML-DmD16-c3    80 wing disc ML-DmD21    44 wing disc ML-DmD32    49 haltere disc ML-DmD17-c3    62 eye-antennal disc ML-DmD11    48 antennal disc ML-DmD20-c5    67 mixed discs ML-DmD4-c1    95 CNS ML-DmBG1-c1    156 CNS ML-DmBG2-c2    196 tumorous blood cells mbn2    89 ovary fGS/OSS    168 ovary OSC    82 ovary OSS    41 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (55) Schneider line 2 Sg4  (53) embryonic 1182-4H  (47) embryonic GM2  (104) embryonic Kc167  (101) embryonic S1  (157) embryonic S3  (72) leg disc CME L1  (81) wing disc CME-W2  (72) wing disc ML-DmD8  (109) wing disc ML-DmD9  (107) wing disc ML-DmD16-c3  (80) wing disc ML-DmD21  (44) wing disc ML-DmD32  (49) haltere disc ML-DmD17-c3  (62) eye-antennal disc ML-DmD11  (48) antennal disc ML-DmD20-c5  (67) mixed discs ML-DmD4-c1  (95) CNS ML-DmBG1-c1  (156) CNS ML-DmBG2-c2  (196) tumorous blood cells mbn2  (89) ovary fGS/OSS  (168) ovary OSC  (82) ovary OSS  (41) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    55 Schneider line 2 Sg4    53 embryonic 1182-4H    47 embryonic GM2  104 embryonic Kc167  101 embryonic S1  (157) embryonic S3    72 leg disc CME L1    81 wing disc CME-W2    72 wing disc ML-DmD8  (109) wing disc ML-DmD9  107 wing disc ML-DmD16-c3    80 wing disc ML-DmD21    44 wing disc ML-DmD32    49 haltere disc ML-DmD17-c3    62 eye-antennal disc ML-DmD11    48 antennal disc ML-DmD20-c5    67 mixed discs ML-DmD4-c1    95 CNS ML-DmBG1-c1  (156) CNS ML-DmBG2-c2  (196) tumorous blood cells mbn2    89 ovary fGS/OSS  (168) ovary OSC    82 ovary OSS    41 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    55 Schneider line 2 Sg4    53 embryonic 1182-4H    47 embryonic GM2    104 embryonic Kc167    101 embryonic S1    157 embryonic S3    72 leg disc CME L1    81 wing disc CME-W2    72 wing disc ML-DmD8    109 wing disc ML-DmD9    107 wing disc ML-DmD16-c3    80 wing disc ML-DmD21    44 wing disc ML-DmD32    49 haltere disc ML-DmD17-c3    62 eye-antennal disc ML-DmD11    48 antennal disc ML-DmD20-c5    67 mixed discs ML-DmD4-c1    95 CNS ML-DmBG1-c1    156 CNS ML-DmBG2-c2    196 tumorous blood cells mbn2    89 ovary fGS/OSS    168 ovary OSC    82 ovary OSS    41 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    55 Schneider line 2 Sg4    53 embryonic 1182-4H    47 embryonic GM2    104 embryonic Kc167    101 embryonic S1    157 embryonic S3    72 leg disc CME L1    81 wing disc CME-W2    72 wing disc ML-DmD8    109 wing disc ML-DmD9    107 wing disc ML-DmD16-c3    80 wing disc ML-DmD21    44 wing disc ML-DmD32    49 haltere disc ML-DmD17-c3    62 eye-antennal disc ML-DmD11    48 antennal disc ML-DmD20-c5    67 mixed discs ML-DmD4-c1    95 CNS ML-DmBG1-c1    156 CNS ML-DmBG2-c2    196 tumorous blood cells mbn2    89 ovary fGS/OSS    168 ovary OSC    82 ovary OSS    41 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (55) Schneider line 2 Sg4  (53) embryonic 1182-4H  (47) embryonic GM2  (104) embryonic Kc167  (101) embryonic S1  (157) embryonic S3  (72) leg disc CME L1  (81) wing disc CME-W2  (72) wing disc ML-DmD8  (109) wing disc ML-DmD9  (107) wing disc ML-DmD16-c3  (80) wing disc ML-DmD21  (44) wing disc ML-DmD32  (49) haltere disc ML-DmD17-c3  (62) eye-antennal disc ML-DmD11  (48) antennal disc ML-DmD20-c5  (67) mixed discs ML-DmD4-c1  (95) CNS ML-DmBG1-c1  (156) CNS ML-DmBG2-c2  (196) tumorous blood cells mbn2  (89) ovary fGS/OSS  (168) ovary OSC  (82) ovary OSS  (41) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    55 Schneider line 2 Sg4    53 embryonic 1182-4H    47 embryonic GM2  104 embryonic Kc167  101 embryonic S1  (157) embryonic S3    72 leg disc CME L1    81 wing disc CME-W2    72 wing disc ML-DmD8  109 wing disc ML-DmD9  107 wing disc ML-DmD16-c3    80 wing disc ML-DmD21    44 wing disc ML-DmD32    49 haltere disc ML-DmD17-c3    62 eye-antennal disc ML-DmD11    48 antennal disc ML-DmD20-c5    67 mixed discs ML-DmD4-c1    95 CNS ML-DmBG1-c1  (156) CNS ML-DmBG2-c2  (196) tumorous blood cells mbn2    89 ovary fGS/OSS  (168) ovary OSC    82 ovary OSS    41 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    55 Schneider line 2 Sg4    53 embryonic 1182-4H    47 embryonic GM2    104 embryonic Kc167    101 embryonic S1    157 embryonic S3    72 leg disc CME L1    81 wing disc CME-W2    72 wing disc ML-DmD8    109 wing disc ML-DmD9    107 wing disc ML-DmD16-c3    80 wing disc ML-DmD21    44 wing disc ML-DmD32    49 haltere disc ML-DmD17-c3    62 eye-antennal disc ML-DmD11    48 antennal disc ML-DmD20-c5    67 mixed discs ML-DmD4-c1    95 CNS ML-DmBG1-c1    156 CNS ML-DmBG2-c2    196 tumorous blood cells mbn2    89 ovary fGS/OSS    168 ovary OSC    82 ovary OSS    41 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    61 cold shock, 4-day adult    37 heat shock, 4-day adult    238 Cadmium 50 mM 6 hrs, larvae L3    242 Cadmium 50 mM 12 hrs, larvae L3    195 Cadmium 50 mM 48 hrs, 4-day adult    253 Cadmium 100 mM 48 hrs, 4-day adult    135 Copper 0.5 mM 12 hrs, larvae L3    164 Copper 15 mM 48 hrs, 4-day adult    68 Zinc 5 mM 12 hrs, larvae L3    100 Zinc 4.5 mM 48 hrs, 4-day adult    77 Ethanol 2.5% 3 hrs, larvae L3    176 Ethanol 5% 3 hrs, larvae L3    253 Ethanol 10% 3 hrs, larvae L3    301 Caffeine 1.5 mg/ml 4 hrs, larvae L3    269 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    135 Caffeine 25 mg/ml 48 hrs, 4-day adult    71 Paraquat 5 mM 48 hrs, 4-day adult    154 Paraquat 10 mM 48 hrs, 4-day adult    254 Rotenone 2 μg 12 hrs, larvae L3    233 Rotenone 8 μg 12 hrs, larvae L3    308 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult  (61) cold shock, 4-day adult  (37) heat shock, 4-day adult  (238) Cadmium 50 mM 6 hrs, larvae L3  (242) Cadmium 50 mM 12 hrs, larvae L3  (195) Cadmium 50 mM 48 hrs, 4-day adult  (253) Cadmium 100 mM 48 hrs, 4-day adult  (135) Copper 0.5 mM 12 hrs, larvae L3  (164) Copper 15 mM 48 hrs, 4-day adult  (68) Zinc 5 mM 12 hrs, larvae L3  (100) Zinc 4.5 mM 48 hrs, 4-day adult  (77) Ethanol 2.5% 3 hrs, larvae L3  (176) Ethanol 5% 3 hrs, larvae L3  (253) Ethanol 10% 3 hrs, larvae L3  (301) Caffeine 1.5 mg/ml 4 hrs, larvae L3  (269) Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (135) Caffeine 25 mg/ml 48 hrs, 4-day adult  (71) Paraquat 5 mM 48 hrs, 4-day adult  (154) Paraquat 10 mM 48 hrs, 4-day adult  (254) Rotenone 2 μg 12 hrs, larvae L3  (233) Rotenone 8 μg 12 hrs, larvae L3  (308) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    61 cold shock, 4-day adult    37 heat shock, 4-day adult  (238) Cadmium 50 mM 6 hrs, larvae L3  (242) Cadmium 50 mM 12 hrs, larvae L3  (195) Cadmium 50 mM 48 hrs, 4-day adult  (253) Cadmium 100 mM 48 hrs, 4-day adult  (135) Copper 0.5 mM 12 hrs, larvae L3  (164) Copper 15 mM 48 hrs, 4-day adult    68 Zinc 5 mM 12 hrs, larvae L3    100 Zinc 4.5 mM 48 hrs, 4-day adult    77 Ethanol 2.5% 3 hrs, larvae L3  (176) Ethanol 5% 3 hrs, larvae L3  (253) Ethanol 10% 3 hrs, larvae L3  (301) Caffeine 1.5 mg/ml 4 hrs, larvae L3  (269) Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (135) Caffeine 25 mg/ml 48 hrs, 4-day adult    71 Paraquat 5 mM 48 hrs, 4-day adult  (154) Paraquat 10 mM 48 hrs, 4-day adult  (254) Rotenone 2 μg 12 hrs, larvae L3  (233) Rotenone 8 μg 12 hrs, larvae L3  (308) Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    61 cold shock, 4-day adult    37 heat shock, 4-day adult    238 Cadmium 50 mM 6 hrs, larvae L3    242 Cadmium 50 mM 12 hrs, larvae L3    195 Cadmium 50 mM 48 hrs, 4-day adult    253 Cadmium 100 mM 48 hrs, 4-day adult    135 Copper 0.5 mM 12 hrs, larvae L3    164 Copper 15 mM 48 hrs, 4-day adult    68 Zinc 5 mM 12 hrs, larvae L3    100 Zinc 4.5 mM 48 hrs, 4-day adult    77 Ethanol 2.5% 3 hrs, larvae L3    176 Ethanol 5% 3 hrs, larvae L3    253 Ethanol 10% 3 hrs, larvae L3    301 Caffeine 1.5 mg/ml 4 hrs, larvae L3    269 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    135 Caffeine 25 mg/ml 48 hrs, 4-day adult    71 Paraquat 5 mM 48 hrs, 4-day adult    154 Paraquat 10 mM 48 hrs, 4-day adult    254 Rotenone 2 μg 12 hrs, larvae L3    233 Rotenone 8 μg 12 hrs, larvae L3    308 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    61 cold shock, 4-day adult    37 heat shock, 4-day adult    238 Cadmium 50 mM 6 hrs, larvae L3    242 Cadmium 50 mM 12 hrs, larvae L3    195 Cadmium 50 mM 48 hrs, 4-day adult    253 Cadmium 100 mM 48 hrs, 4-day adult    135 Copper 0.5 mM 12 hrs, larvae L3    164 Copper 15 mM 48 hrs, 4-day adult    68 Zinc 5 mM 12 hrs, larvae L3    100 Zinc 4.5 mM 48 hrs, 4-day adult    77 Ethanol 2.5% 3 hrs, larvae L3    176 Ethanol 5% 3 hrs, larvae L3    253 Ethanol 10% 3 hrs, larvae L3    301 Caffeine 1.5 mg/ml 4 hrs, larvae L3    269 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    135 Caffeine 25 mg/ml 48 hrs, 4-day adult    71 Paraquat 5 mM 48 hrs, 4-day adult    154 Paraquat 10 mM 48 hrs, 4-day adult    254 Rotenone 2 μg 12 hrs, larvae L3    233 Rotenone 8 μg 12 hrs, larvae L3    308 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult  (61) cold shock, 4-day adult  (37) heat shock, 4-day adult  (238) Cadmium 50 mM 6 hrs, larvae L3  (242) Cadmium 50 mM 12 hrs, larvae L3  (195) Cadmium 50 mM 48 hrs, 4-day adult  (253) Cadmium 100 mM 48 hrs, 4-day adult  (135) Copper 0.5 mM 12 hrs, larvae L3  (164) Copper 15 mM 48 hrs, 4-day adult  (68) Zinc 5 mM 12 hrs, larvae L3  (100) Zinc 4.5 mM 48 hrs, 4-day adult  (77) Ethanol 2.5% 3 hrs, larvae L3  (176) Ethanol 5% 3 hrs, larvae L3  (253) Ethanol 10% 3 hrs, larvae L3  (301) Caffeine 1.5 mg/ml 4 hrs, larvae L3  (269) Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (135) Caffeine 25 mg/ml 48 hrs, 4-day adult  (71) Paraquat 5 mM 48 hrs, 4-day adult  (154) Paraquat 10 mM 48 hrs, 4-day adult  (254) Rotenone 2 μg 12 hrs, larvae L3  (233) Rotenone 8 μg 12 hrs, larvae L3  (308) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    61 cold shock, 4-day adult    37 heat shock, 4-day adult  (238) Cadmium 50 mM 6 hrs, larvae L3  (242) Cadmium 50 mM 12 hrs, larvae L3  (195) Cadmium 50 mM 48 hrs, 4-day adult  (253) Cadmium 100 mM 48 hrs, 4-day adult  135 Copper 0.5 mM 12 hrs, larvae L3  (164) Copper 15 mM 48 hrs, 4-day adult    68 Zinc 5 mM 12 hrs, larvae L3    100 Zinc 4.5 mM 48 hrs, 4-day adult    77 Ethanol 2.5% 3 hrs, larvae L3  (176) Ethanol 5% 3 hrs, larvae L3  (253) Ethanol 10% 3 hrs, larvae L3  (301) Caffeine 1.5 mg/ml 4 hrs, larvae L3  (269) Caffeine 2.5 mg/ml 48 hrs, 4-day adult  135 Caffeine 25 mg/ml 48 hrs, 4-day adult    71 Paraquat 5 mM 48 hrs, 4-day adult  (154) Paraquat 10 mM 48 hrs, 4-day adult  (254) Rotenone 2 μg 12 hrs, larvae L3  (233) Rotenone 8 μg 12 hrs, larvae L3  (308) Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    61 cold shock, 4-day adult    37 heat shock, 4-day adult    238 Cadmium 50 mM 6 hrs, larvae L3    242 Cadmium 50 mM 12 hrs, larvae L3    195 Cadmium 50 mM 48 hrs, 4-day adult    253 Cadmium 100 mM 48 hrs, 4-day adult    135 Copper 0.5 mM 12 hrs, larvae L3    164 Copper 15 mM 48 hrs, 4-day adult    68 Zinc 5 mM 12 hrs, larvae L3    100 Zinc 4.5 mM 48 hrs, 4-day adult    77 Ethanol 2.5% 3 hrs, larvae L3    176 Ethanol 5% 3 hrs, larvae L3    253 Ethanol 10% 3 hrs, larvae L3    301 Caffeine 1.5 mg/ml 4 hrs, larvae L3    269 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    135 Caffeine 25 mg/ml 48 hrs, 4-day adult    71 Paraquat 5 mM 48 hrs, 4-day adult    154 Paraquat 10 mM 48 hrs, 4-day adult    254 Rotenone 2 μg 12 hrs, larvae L3    233 Rotenone 8 μg 12 hrs, larvae L3    308 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010, Graveley et al., 2011) mE2_34_mRNA_expression_cluster_10 mE1_20_mRNA_expression_cluster_10
External Data & Images
Linkouts	BDGP expression data • GH13575 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0003074 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG8251-RA FlyExpress - Embryonic expression images (BDGP data) • Show all FlyExpress processed images for Pgi Stages(s) 4-6 Stages(s) 7-8 Stages(s) 11-12
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal | recessive PginNC1 viable PgiEY09730 viable, with Scer\GAL4pnr-MD237 PgiGD13860 Sterility Allele fertile PgiEY09730 Other Phenotypes Allele electrophoretic variant | slow Pgi2 Pgi4 Phenotype manifest in Allele
Classical Alleles ( 18 )
For All Classical Alleles Show
Allele of Pgi Class Mutagen Stocks Known lesion Pgi2 3 -- Pgi4 3 -- PginNC1 loss of function allele natural population 2 -- Pgi5-HA-1037 1 -- Pgid02342 P-element activity 1 -- PgiEY09730 P-element activity 1 -- Pgi985A natural population 0 -- PgiAf-F natural population 0 -- PgiAf-S natural population 0 -- PgiFl-1F natural population 0 -- PgiFl-1S natural population 0 -- PgiFl-2S natural population 0 -- PgiFr-F natural population 0 -- PgiFr-S natural population 0 -- PgiJa-F natural population 0 -- PgiJa-S natural population 0 -- PgiWa-F natural population 0 -- PgiWa-S natural population 0 --
Alleles Carried on Transgenic Constructs ( 4 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Pgi Class Mutagen Stocks Known lesion PgiGD13860 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes PgiKK101740 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes PgiNIG.8251R in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes PgiScer\UAS.cTa in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(2R)Exel8048 (Ryder, 2004.4.26)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD13860} NA P{KK101740} NA P{NIG.8251R} NA P{UAS-Pgi.T} NA
Insertions
	Type of insertions Name Expression data insertion of mobile activating element P{EPgy2}PgiEY09730 NA P{XP}Pgid02342 NA miscellaneous insertions P{RS5}Pgi5-HA-1037 NA insertion of enhancer trap P{lacW}l(2)SH0623SH0623 No
Gene Ontology: Function, Process & Cellular Component ( 6 unique terms )
Terms Based on Experimental Evidence ( 2 terms )
Molecular Function
CV term Evidence References
glucose-6-phosphate isomerase activity inferred from mutant phenotype (Eanes et al., 2006)
Biological Process ( 0 terms)
Cellular Component
CV term Evidence References
lipid particle inferred from direct assay (Beller et al., 2006)
Terms Based on Predictions or Assertions ( 5 terms )
Molecular Function
CV term Evidence References
glucose-6-phosphate isomerase activity non-traceable author statement (Swiss-Prot Project Members, 1996.10.1) phosphogluconate dehydrogenase (decarboxylating) activity inferred from sequence or structural similarity with Saccharomyces PGI1 (FlyBase, 1992-) traceable author statement (Choudhary et al., 1992)
Biological Process
CV term Evidence References
gluconeogenesis inferred from electronic annotation with InterPro:IPR001672, InterPro:IPR018189 (FlyBase Curators et al., 2004-) non-traceable author statement (Swiss-Prot Project Members, 1996.10.1) glycolysis inferred from electronic annotation with InterPro:IPR001672, InterPro:IPR018189 (FlyBase Curators et al., 2004-) non-traceable author statement (Swiss-Prot Project Members, 1996.10.1)
Cellular Component
CV term Evidence References
cytoplasm non-traceable author statement (Swiss-Prot Project Members, 1996.10.1)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
protein-protein
Interacting group Assay References
Pgi - CG6330 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Pgi - Hr46 experimental knowledge based, anti tag coimmunoprecipitation, peptide massfingerprinting (Guruharsha et al., 2011, Mintseris et al., 2009.11.23) Pgi - Rpb8 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Pgi - YL-1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Pgi - msl-3 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Pgi - ovo anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23)
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Pgi allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 61725 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0003074 DroID - A comprehensive database of gene and protein interactions. • FBgn0003074 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 35886
Orthologs
OrthoDB Orthologs (43) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG608NTK Dipteran inclusive ortholog search EOG64J2S9 Insect inclusive ortholog search EOG6CVF32 Arthropod inclusive ortholog search EOG60ZPCQ Metazoa inclusive ortholog search EOG6ZWJ47
Orthologs in Drosophila Species (EOG608NTK)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\Pgi     Drosophila sechellia   Dsec\GM20655 Y   Drosophila erecta   Dere\GG10610 Y   Drosophila yakuba   Dyak\Pgi Y   Drosophila ananassae   Dana\GF12560 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA20931 Y   Drosophila persimilis   Dper\GL10407 Y   Drosophila willistoni   Dwil\GK21948 Y   Drosophila virilis   Dvir\GJ21054 Y   Drosophila mojavensis   Dmoj\GI20614 Y   Drosophila grimshawi   Dgri\GH22686 Y
Orthologs in non-Drosophila Dipterans (EOG64J2S9)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL012665   Aedes aegypti Yellow fever mosquito  Aaeg\AAEL012994   Anopheles gambiae Malaria mosquito  Agam\AGAP012167   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ017610   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ006486
Orthologs in non-Dipteran Insects (EOG6CVF32)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\LOC551154   Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG013232   Acromyrmex echinatior Panamanian leafcutter ant  Aech\pgi   Atta cephalotes Leafcutter ant  Acep\ACEP19251   Camponotus floridanus Florida carpenter ant  Cflo\pgi   Harpegnathos saltator Jerdons jumping ant  Hsal\pgi   Linepithema humile Argentine ant  Lhum\LH14919   Pogonomyrmex barbatus Red harvester ant  Pbar\PB11745   Solenopsis invicta Red fire ant  Sinv\SINV25679   Acyrthosiphon pisum Pea aphid  Apim\ACYPI002404   Bombyx mori Silkmoth  Bmor\BGIBMGA004221   Pediculus humanus Human body louse  Phum\PHUM227950   Tribolium castaneum Red flour beetle  Tcas\TC030755
Orthologs in non-Insect Arthropods (EOG60ZPCQ)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\JGI_V11_302344   Ixodes scapularis Deer tick  Isca\ISCW014868
Orthologs in non-Arthropod Metazoa (EOG6ZWJ47)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Caenorhabditis elegans Nematode  Cele\gpi-1   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_014856gn   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_012839gn   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_011119gn   Danio rerio Zebrafish  Drer\gpib   Danio rerio Zebrafish  Drer\gpia   Xenopus tropicalis Western clawed frog  Xtro\gpi   Gallus gallus Domestic chicken  Ggal\GPI   Mus musculus House mouse  Mmus\Gpi   Mus musculus House mouse  Mmus\Gm1840   Rattus norvegicus Norway rat  Rnor\Gpi   Homo sapiens Human  Hsap\GPI
Human Orthologs (1)
Gene OMIM HGNC Hsap\GPI
AAA Orthologs (10) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila sechellia Dsec\GM20655 Drosophila erecta Dere\GG10610 Drosophila yakuba Dyak\Pgi Drosophila ananassae Dana\GF12560 Drosophila pseudoobscura pseudoobscura Dpse\GA20931 Drosophila persimilis Dper\GL10407 Drosophila willistoni Dwil\GK21948 Drosophila virilis Dvir\GJ21054 Drosophila mojavensis Dmoj\GI20614 Drosophila grimshawi Dgri\GH22686
Stocks & Reagents
Stocks Listed in FlyBase ( 11 )
Bloomington	17595 y1 w67c23; P{EPgy2}PgiEY09730 4068 Pgk2 Pgi2/SM1, Pgk4 Pgi4; Men6 ryel-S Aldox-13 Mdh26/TM6, Men4 ryel-F Aldox-1L4 Mdh24
Harvard	- P{XP}Pgid02342
Kyoto	107552 PginNC1/SM1 101350 cn1 PginNC1 / SM5 125023 w1118; P{RS5}Pgi5-HA-1037 107571 Pgk2 Pgi2/SM1, Pgk4 Pgi4; Men6 ryel-S Aldox-13 Mdh26/TM6, Men4 ryel-F Aldox-1L4 Mdh24 103359 SM1, al2 Cy1 cn2 sp2 Pgk4 Pgi4 / Pgk2 Pgi2 ; TM6, HnP ssaP88 Ubxbx-34e UbxP15 e1 Men4 ryel-F Aldox-1L4 Mdh2* / Men6 ryel-S Aldox-13 Mdh2*
VDRC	v103616 P{KK101740}VIE-260B v24257 w1118; P{GD13860}v24257 v24258 w1118; P{GD13860}v24258
Genomic Clones ( 1 )
	BACR02C23 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 254 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	GH13575
Other clones	DPiM_GH13575
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	AT03254 AT05070 AT05516 AT08493 AT09149 AT09876 AT10201 AT10991 AT12766 AT12776 AT13073 AT17288 AT18949 AT20081 AT20370 AT23661 AT24195 AT29892 AT30336 AT30513 GH01506 GH04555 GH04775 GH04890 GH05593 GH06779 GH07865 GH10890 GH11031 GH13103 GH16513 GH21074 GH21537 GH21920 GH23890 GH25217 GH26095 GH27635 GM01428 GM03176 GM03434 GM03667 GM13474 HL01194 HL05302 HL07434 LD05836 LD27701 LD28386 LP04134 LP08251 LP10258 LP11010 LP17450 LP17989 LP22337 LP24121 RE02090 RE07720 RE25193 RE27795 RE32952 RE39181 RE39695 RE45674 RE52219 RE55435 RE65165 RE66048 RE67707 RE67964 RE72011 RE74367 RH03695 RH04173 RH04383 RH04564 RH04931 RH05008 RH05016 RH05343 RH06205 RH08046 RH08460 RH08801 RH10125 RH16774 RH21536 RH24819 RH26164 RH27439 RH27635 RH28742 RH28814 RH31115 RH31572 RH31637 RH32131 RH33604 RH34216 RH35156 RH36715 RH36724 RH37093 RH38662 RH40044 RH42505 RH43739 RH45806 RH51345 RH60076 RH60259 RH62379 RH66722 RH66860 RH68212 RH68454 RH69051 RH70312 RH70934 RH71637 RH72315 RH73780 RH74337 SD01610 SD03763 SD11838 SD13043 SD18758 SD23848 SD23949 SD27744
Other clones	5285 57936 62341 62845 66754 193898 274557 568906 AT01265 bs10a05 bs20e10 bs33b08 bs53f12 bs69a10 Dmel_dig_015706_0580_2920 Dmel_neb_012472_0951_0861 Dmel_neb_013158_0819_2252 Dmel_neb_013243_0372_2276 Dmel_neb_014545_0924_2895 Dmel_neb_014740_0198_3385 EC29376 EC40664 EK065748 EK124348 EK188025 EK188637 EK194419 EK236602 EK302449 GH06237 GH11030 GH17458 GH24207 HL01068 HL01542 HL02826 IP04705 IP06495 IP06695 IP06795 IP10814 LD08803 LD20176 LP02950 RC0-DA0001-130700-211-E11 RE05425 RE07907 RE18817 RE56577 RH02103 RH04993 RH06508 RH08457 RH16825 RH21378 RH21578 RH21582 RH23102 RH27446 RH29764 RH29830 RH30244 RH30573 RH31772 RH32091 RH33613 RH34705 RH36162 RH37826 RH39662 RH43393 RH45923 RH48503 RH52774 RH52956 RH58443 RH58467 RH60408 RH64146 RH66396 RH68476 RH69654 RH71106 RH71194 RP004003655 RP004059451 RP004068084 RP004090872 RP004092424 RP004092914 RP004138661 RP004162257 RP004165474 RP004202102 RP004230862 RP004234551 RP004240284 RP004241596 RP004249029 RP004256548 RP004264642 RP004280807 RP004332911 RP004336151 RP004343048 RP004352638 RP004374149 RP004395926 RP004417119 RP004442904 RP004462313 RP004465257 RP004471186 RP004483376 RP004484157 RP004494949 RP004539356 RP004552486 UUGC0923 UUGC1154
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0003074 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 35886
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of
Additional comments
Other Comments
	One of 42 Drosophila genes identified as being most likely to reveal molecular and cellular mechanisms of nervous system development or plasticity relevant to human Mental Retardation disorders. (Inlow and Restifo, 2004) Quantifying rates of protein sequence divergence within and between species reveals that the Drosophila genome harbors a substantial proportion of genes with a very high divergence rate. (Schmid and Tautz, 1997) The effects of a high sucrose diet on live weight, total protein, stored lipid and glycogen and crude activities of 12 enzymes involved in energy metabolism are quantified. The activities of many enzymes are reduced by the sucrose treatment. (Wang and Clark, 1995) Structural gene for the glycolytic enzyme phosphoglucose isomerase (PGI). There are two electrophoretic variants (fast and slow).
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_078939 NM_165635 NM_165636 RefSeq (Proteins) • NP_523663 NP_724723 NP_724724 DDBJ / EMBL / GenBank • AAA28789 AAA28790 AAA28791 AAA28792 AAA28793 AAA28794 AAA28795 AAA28796 AAA28803 AAA28804 AAA28805 AAA63671 AAA63672 AAA63673 AAA63674 AAA63675 AAA63676 AAA63677 AAA63678 AAA63679 AAA63680 AAF59025 AAK92892 AAM71090 AAM71091 AC006074 AI135724 AI259520 AI296388 AI404250 AI513259 AI945190 AI946073 AI946932 AY051468 CL526137 CZ472764 L27539 L27540 L27541 L27542 L27543 L27544 L27545 L27546 L27553 L27554 L27555 U20566 U20567 U20568 U20569 U20570 U20571 U20572 U20573 U20574 U20575 Z50557 Entrez Gene - A searchable database of RefSeq genes. • 35886 UniProtKB/Swiss-Prot • P52029
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Phosphoglucose isomerase, conserved site (IPR018189) Phosphoglucose isomerase (PGI) (IPR001672) Phosphoglucose isomerase, C-terminal (IPR023096) BDGP expression data - Patterns of gene expression in Drosophila embryogenesis • GH13575
Linkouts
	BioGRID - A database of protein and genetic interactions • 61725 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0003074 DroID - A comprehensive database of gene and protein interactions. • FBgn0003074 DRSC - Results from RNAi screens. • FBgn0003074 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0003074 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG8251-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0003074 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 35886 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 35886 modMine - Data generated by the modENCODE project. • FBgn0003074
Synonyms & Secondary IDs ( 10 )
Reported As
Symbol Synonym	CG8251 (Chandonia and Cohen, 2003, Keleman et al., 2009.8.5, Cammarato et al., 2011) GPI (Schulz and Bahr, 2003) Gpi (Matthews and Munstermann, 1994) pgi (Hatini et al., 2000, Rehwinkel et al., 2005) PGI (Clark and Wang, 1997, Wang and Clark, 1995, Clark, 1994, Clark and Wang, 1994, Choudhary et al., 1992, Clark et al., 1990, Clark, 1990, Pierce et al., 2001, Saj et al., 2010) Pgi (Beller et al., 2006, Flowers et al., 2007, Dorus et al., 2006, Sandmann et al., 2006, Lai et al., 2007, Eanes et al., 2006, Curtis et al., 2007, Tennessen et al., 2011, Wasbrough et al., 2010, Japanese National Institute of Genetics, 2012.5.21) Phosphoglucose isomerase (Kaltenbach et al., 2007)
Name Synonym	glucose phosphate isomerase (Calleja et al., 1993, Medina and Vallejo, 1991) phosphoglucoisomerase (Pierce et al., 2001) Phosphoglucose isomerase (Kaltenbach et al., 2007, Harbison et al., 2005, Cammarato et al., 2011) phosphoglucose isomerase (Curtis et al., 2007, Tennessen et al., 2011)
Secondary FlyBase IDs
References ( 97 )
Generate a list of	All references relating to this gene ( 97 )
List References by type	Research paper  ( 66 ) Supplementary material  ( 11 ) Review  ( 1 ) Personal communication to FlyBase  ( 10 ) FlyBase analysis  ( 2 ) Stock list  ( 1 ) Protein sequence record  ( 1 ) Website  ( 1 ) Book  ( 1 ) Letter  ( 1 ) Curated genome annotation  ( 1 )
Recent research papers ( 1 )
	Tennessen et al., 2011, Cell Metab. 13(2): 139--148 The Drosophila Estrogen-Related Receptor Directs a Metabolic Switch that Supports Developmental Growth. [FBrf0212927] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2011 Show reviews ...