General Information
Symbol
Dmel\Pgm1
Species
D. melanogaster
Name
Phosphoglucose mutase 1
Annotation Symbol
CG5165
Feature Type
FlyBase ID
FBgn0003076
Gene Model Status
Stock Availability
Enzyme Name (EC)
Phosphoglucomutase (alpha-D-glucose-1,6-bisphosphate-dependent) (5.4.2.2)
Gene Snapshot
In progress.Contributions welcome.
Also Known As
Pgm, PGM-1
Genomic Location
Cytogenetic map
Sequence location
3L:16,126,018..16,128,531 [-]
Recombination map
3-44
Sequence
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
GO Summary Ribbons
Families, Domains and Molecular Function
Gene Group Membership (FlyBase)
Protein Family (UniProt, Sequence Similarities)
Belongs to the phosphohexose mutase family. (Q9VUY9)
Molecular Function (see GO section for details)
Catalytic Activity (EC)
Experimental Evidence
Alpha-D-glucose 1-phosphate = alpha-D-glucose 6-phosphate (5.4.2.2)
Predictions / Assertions
Alpha-D-glucose 1-phosphate = alpha-D-glucose 6-phosphate (5.4.2.2)
Summaries
Gene Group Membership
INTRAMOLECULAR PHOSPHOTRANSFERASES -
Intramolecular phosphotransferases catalyze the transfer of a phosphate group from one part of a molecule to another. (Adapted from FBrf0238665.)
UniProt Contributed Function Data
This enzyme participates in both the breakdown and synthesis of glucose.
(UniProt, Q9VUY9)
Phenotypic Description from the Red Book (Lindsley and Zimm 1992)
Pgm: Phosphoglucomutase
Structural gene for the glycolytic enzyme phosphoglucomutase [PGM (E.C. 2.7.5.1)], a monomeric protein of 56,000 daltons. Two frequently-occurring electrophoretic variants were isolated and studied by Hjorth (1970a,b) and Trippa et al. (1970, 1971). Later five low-frequency variants were found by Trippa's group (see references in table of alleles). One null allele found in a total of 431 alleles collected in Great Britain (Langley, Voelker, Leigh-Brown, Ohnishi, Dickson, and Montgomery, 1981, Genetics 99: 151-56).
Gene Model and Products
Number of Transcripts
1
Number of Unique Polypeptides
1

Please see the GBrowse view of Dmel\Pgm1 or the JBrowse view of Dmel\Pgm1 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model
Gene model reviewed during 5.46
Sequence Ontology: Class of Gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
FBtr0075492
1843
560
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
FBpp0075247
60.8
560
6.68
Polypeptides with Identical Sequences

There is only one protein coding transcript and one polypeptide associated with this gene

Additional Polypeptide Data and Comments
Reported size (kDa)
958 (aa)
Comments
External Data
Linkouts
Sequences Consistent with the Gene Model
Nucleotide / Polypeptide Records
 
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Pgm1 using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Gene Ontology (6 terms)
Molecular Function (2 terms)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
inferred from electronic annotation with InterPro:IPR016066
(assigned by InterPro )
inferred from sequence or structural similarity with UniProtKB:P36871
(assigned by UniProt )
inferred from biological aspect of ancestor with PANTHER:PTN000501426
(assigned by GO_Central )
Biological Process (3 terms)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
Terms Based on Predictions or Assertions (3 terms)
CV Term
Evidence
References
inferred from biological aspect of ancestor with PANTHER:PTN000501426
(assigned by GO_Central )
inferred from biological aspect of ancestor with PANTHER:PTN000501426
(assigned by GO_Central )
inferred from biological aspect of ancestor with PANTHER:PTN000501426
(assigned by GO_Central )
Cellular Component (1 term)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
inferred from biological aspect of ancestor with PANTHER:PTN000501426
(assigned by GO_Central )
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\Pgm1 in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
Alleles, Insertions, and Transgenic Constructs
Classical and Insertion Alleles ( 63 )
For All Classical and Insertion Alleles Show
 
Allele of Pgm1
Class
Mutagen
Associated Insertion
Stocks
Known lesion
    0
    --
      0
      --
        0
        --
        Other relevant insertions
        Transgenic Constructs ( 5 )
        For All Alleles Carried on Transgenic Constructs Show
        Transgenic constructs containing/affecting coding region of Pgm1
        Allele of Pgm1
        Mutagen
        Associated Transgenic Construct
        Stocks
        Transgenic constructs containing regulatory region of Pgm1
        Deletions and Duplications ( 3 )
        Phenotypes
        Orthologs
        Human Orthologs (via DIOPT v7.1)
        Homo sapiens (Human) (7)
        Species\Gene Symbol
        Score
        Best Score
        Best Reverse Score
        Alignment
        Complementation?
        Transgene?
        14 of 15
        Yes
        Yes
        12 of 15
        No
        Yes
        1 of 15
        No
        No
        1 of 15
        No
        No
        1 of 15
        No
        No
        1 of 15
        No
        No
        1 of 15
        No
        Yes
        Model Organism Orthologs (via DIOPT v7.1)
        Mus musculus (laboratory mouse) (5)
        Species\Gene Symbol
        Score
        Best Score
        Best Reverse Score
        Alignment
        Complementation?
        Transgene?
        13 of 15
        Yes
        Yes
        12 of 15
        No
        Yes
        1 of 15
        No
        No
        1 of 15
        No
        No
        1 of 15
        No
        No
        Rattus norvegicus (Norway rat) (5)
        12 of 13
        Yes
        Yes
        6 of 13
        No
        Yes
        1 of 13
        No
        No
        1 of 13
        No
        No
        1 of 13
        No
        No
        Xenopus tropicalis (Western clawed frog) (4)
        10 of 12
        Yes
        Yes
        7 of 12
        No
        Yes
        1 of 12
        No
        No
        1 of 12
        No
        No
        Danio rerio (Zebrafish) (9)
        11 of 15
        Yes
        Yes
        10 of 15
        No
        Yes
        1 of 15
        No
        No
        1 of 15
        No
        No
        1 of 15
        No
        No
        1 of 15
        No
        No
        1 of 15
        No
        No
        1 of 15
        No
        No
        1 of 15
        No
        No
        Caenorhabditis elegans (Nematode, roundworm) (6)
        13 of 15
        Yes
        Yes
        1 of 15
        No
        No
        1 of 15
        No
        No
        1 of 15
        No
        No
        1 of 15
        No
        No
        1 of 15
        No
        No
        Arabidopsis thaliana (thale-cress) (3)
        9 of 9
        Yes
        Yes
        7 of 9
        No
        Yes
        7 of 9
        No
        Yes
        Saccharomyces cerevisiae (Brewer's yeast) (2)
        15 of 15
        Yes
        Yes
        13 of 15
        No
        Yes
        Schizosaccharomyces pombe (Fission yeast) (1)
        12 of 12
        Yes
        Yes
        Orthologs in Drosophila Species (via OrthoDB v9.1) ( EOG091904Z3 )
        Organism
        Common Name
        Gene
        AAA Syntenic Ortholog
        Multiple Dmel Genes in this Orthologous Group
        Drosophila melanogaster
        fruit fly
        Drosophila suzukii
        Spotted wing Drosophila
        Drosophila simulans
        Drosophila sechellia
        Drosophila erecta
        Drosophila yakuba
        Drosophila ananassae
        Drosophila pseudoobscura pseudoobscura
        Drosophila persimilis
        Drosophila willistoni
        Drosophila virilis
        Drosophila mojavensis
        Drosophila grimshawi
        Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG0915051Y )
        Organism
        Common Name
        Gene
        Multiple Dmel Genes in this Orthologous Group
        Musca domestica
        House fly
        Musca domestica
        House fly
        Glossina morsitans
        Tsetse fly
        Lucilia cuprina
        Australian sheep blowfly
        Mayetiola destructor
        Hessian fly
        Mayetiola destructor
        Hessian fly
        Aedes aegypti
        Yellow fever mosquito
        Aedes aegypti
        Yellow fever mosquito
        Anopheles darlingi
        American malaria mosquito
        Anopheles darlingi
        American malaria mosquito
        Anopheles gambiae
        Malaria mosquito
        Anopheles gambiae
        Malaria mosquito
        Anopheles gambiae
        Malaria mosquito
        Culex quinquefasciatus
        Southern house mosquito
        Culex quinquefasciatus
        Southern house mosquito
        Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W062E )
        Organism
        Common Name
        Gene
        Multiple Dmel Genes in this Orthologous Group
        Bombyx mori
        Silkmoth
        Bombyx mori
        Silkmoth
        Danaus plexippus
        Monarch butterfly
        Danaus plexippus
        Monarch butterfly
        Heliconius melpomene
        Postman butterfly
        Heliconius melpomene
        Postman butterfly
        Apis florea
        Little honeybee
        Apis florea
        Little honeybee
        Apis mellifera
        Western honey bee
        Apis mellifera
        Western honey bee
        Bombus impatiens
        Common eastern bumble bee
        Bombus impatiens
        Common eastern bumble bee
        Bombus terrestris
        Buff-tailed bumblebee
        Bombus terrestris
        Buff-tailed bumblebee
        Linepithema humile
        Argentine ant
        Linepithema humile
        Argentine ant
        Megachile rotundata
        Alfalfa leafcutting bee
        Megachile rotundata
        Alfalfa leafcutting bee
        Nasonia vitripennis
        Parasitic wasp
        Nasonia vitripennis
        Parasitic wasp
        Dendroctonus ponderosae
        Mountain pine beetle
        Dendroctonus ponderosae
        Mountain pine beetle
        Tribolium castaneum
        Red flour beetle
        Tribolium castaneum
        Red flour beetle
        Pediculus humanus
        Human body louse
        Pediculus humanus
        Human body louse
        Rhodnius prolixus
        Kissing bug
        Rhodnius prolixus
        Kissing bug
        Cimex lectularius
        Bed bug
        Cimex lectularius
        Bed bug
        Cimex lectularius
        Bed bug
        Acyrthosiphon pisum
        Pea aphid
        Acyrthosiphon pisum
        Pea aphid
        Zootermopsis nevadensis
        Nevada dampwood termite
        Zootermopsis nevadensis
        Nevada dampwood termite
        Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X07RI )
        Organism
        Common Name
        Gene
        Multiple Dmel Genes in this Orthologous Group
        Strigamia maritima
        European centipede
        Strigamia maritima
        European centipede
        Ixodes scapularis
        Black-legged tick
        Ixodes scapularis
        Black-legged tick
        Ixodes scapularis
        Black-legged tick
        Ixodes scapularis
        Black-legged tick
        Ixodes scapularis
        Black-legged tick
        Ixodes scapularis
        Black-legged tick
        Ixodes scapularis
        Black-legged tick
        Stegodyphus mimosarum
        African social velvet spider
        Stegodyphus mimosarum
        African social velvet spider
        Stegodyphus mimosarum
        African social velvet spider
        Tetranychus urticae
        Two-spotted spider mite
        Tetranychus urticae
        Two-spotted spider mite
        Tetranychus urticae
        Two-spotted spider mite
        Tetranychus urticae
        Two-spotted spider mite
        Daphnia pulex
        Water flea
        Daphnia pulex
        Water flea
        Daphnia pulex
        Water flea
        Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G0HZ0 )
        Organism
        Common Name
        Gene
        Multiple Dmel Genes in this Orthologous Group
        Strongylocentrotus purpuratus
        Purple sea urchin
        Strongylocentrotus purpuratus
        Purple sea urchin
        Strongylocentrotus purpuratus
        Purple sea urchin
        Strongylocentrotus purpuratus
        Purple sea urchin
        Strongylocentrotus purpuratus
        Purple sea urchin
        Strongylocentrotus purpuratus
        Purple sea urchin
        Strongylocentrotus purpuratus
        Purple sea urchin
        Strongylocentrotus purpuratus
        Purple sea urchin
        Strongylocentrotus purpuratus
        Purple sea urchin
        Strongylocentrotus purpuratus
        Purple sea urchin
        Ciona intestinalis
        Vase tunicate
        Ciona intestinalis
        Vase tunicate
        Ciona intestinalis
        Vase tunicate
        Ciona intestinalis
        Vase tunicate
        Ciona intestinalis
        Vase tunicate
        Ciona intestinalis
        Vase tunicate
        Ciona intestinalis
        Vase tunicate
        Gallus gallus
        Domestic chicken
        Gallus gallus
        Domestic chicken
        Gallus gallus
        Domestic chicken
        Gallus gallus
        Domestic chicken
        Gallus gallus
        Domestic chicken
        Human Disease Model Data
        FlyBase Human Disease Model Reports
          Alleles Reported to Model Human Disease (Disease Ontology)
          Download
          Models ( 0 )
          Allele
          Disease
          Evidence
          References
          Interactions ( 1 )
          Allele
          Disease
          Interaction
          References
          Comments ( 0 )
           
          Human Orthologs (via DIOPT v7.1)
          Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
          Homo sapiens (Human)
          Gene name
          Score
          OMIM
          OMIM Phenotype
          Complementation?
          Transgene?
          Functional Complementation Data
          Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
          Interactions
          Summary of Physical Interactions
          esyN Network Diagram
          Interactions Browser
          Summary of Genetic Interactions
          esyN Network Diagram
          Starting gene(s)
          Interaction type
          Interacting gene(s)
          Reference
          Starting gene(s)
          Interaction type
          Interacting gene(s)
          Reference
          External Data
          Linkouts
          BioGRID - A database of protein and genetic interactions.
          DroID - A comprehensive database of gene and protein interactions.
          InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
          Pathways
          Genomic Location and Detailed Mapping Data
          Chromosome (arm)
          3L
          Recombination map
          3-44
          Cytogenetic map
          Sequence location
          3L:16,126,018..16,128,531 [-]
          FlyBase Computed Cytological Location
          Cytogenetic map
          Evidence for location
          72D8-72D8
          Limits computationally determined from genome sequence between P{lacW}thj5C8&P{PZ}Mbs03802 and P{lacW}SsRβs1939
          Experimentally Determined Cytological Location
          Cytogenetic map
          Notes
          References
          Experimentally Determined Recombination Data
          Notes
          Stocks and Reagents
          Stocks (9)
          Genomic Clones (14)
           

          Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

          cDNA Clones (164)
           

          Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

          cDNA clones, fully sequences
          BDGP DGC clones
          Other clones
          Drosophila Genomics Resource Center cDNA clones

          For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

          cDNA Clones, End Sequenced (ESTs)
          RNAi and Array Information
          Linkouts
          DRSC - Results frm RNAi screens
          GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
          Antibody Information
          Laboratory Generated Antibodies
           
          Commercially Available Antibodies
           
          Other Information
          Relationship to Other Genes
          Source for database identify of
          Source for identity of: Pgm1 Pgm
          Source for database merge of
          Source for merge of: Pgm CG5165
          Additional comments
          Renamed from 'Pgm' to 'Pgm1' (i.e. added the '1' suffix) to distinguish this gene from the two Pgm2 genes and consistently reflect orthology to the vertebrate genes.
          Source for merge of Pgm CG5165 was sequence comparison ( date:010104 ).
          Other Comments
          The effects of a high sucrose diet on live weight, total protein, stored lipid and glycogen and crude activities of 12 enzymes involved in energy metabolism are quantified. The activities of many enzymes are reduced by the sucrose treatment.
          Gramoxone has no mutagenic effect on the genetic background of Pgm.
          The synergistic effects of the Adh locus, or a tightly linked locus, on the quantities of the Mdh1, Gpdh, Pgm, Idh, Men and Gapdh1 gene products in D.melanogaster derived from an African population has been determined.
          No difference in allele fixed in lines selected over 700 generations for high (negative) and low (positive) geotaxis.
          Heat denaturation, isoelectric focusing and the degree of genetic variation at the Pgm locus has been examined in laboratory populations.
          Heat denaturation study has been used to detect genetic heterogeneity within electrophoretic classes at the Pgm locus.
          Thermostability study of the Pgm locus reveals temperature-resistant and temperature-sensitive mutants.
          Structural gene for the glycolytic enzyme phosphoglucomutase (PGM), a monomeric protein of 56,000 daltons. Two frequently-occurring electrophoretic variants were isolated and studied by Hjorth, 1970; Hjorth, 1970 and Trippa et al., 1970; Trippa et al., 1971. Later five low-frequency variants were found by Trippa's group (see references under alleles). One null allele found in a total of 431 alleles collected in Great Britain (Langley, Voelker, Leigh-Brown, Ohnishi, Dickson and Montgomery, 1981).
          Origin and Etymology
          Discoverer
          Etymology
          Identification
          External Crossreferences and Linkouts ( 149 )
          Sequence Crossreferences
          NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
          RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
          UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
          Linkouts
          BioGRID - A database of protein and genetic interactions.
          Drosophila Genomics Resource Center - Drosophila Genomics Resource Center cDNA clones
          DPiM - Drosophila Protein interaction map
          DroID - A comprehensive database of gene and protein interactions.
          DRSC - Results frm RNAi screens
          Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
          FLIGHT - Cell culture data for RNAi and other high-throughput technologies
          FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
          FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
          Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
          Flygut - An atlas of the Drosophila adult midgut
          FlyMine - An integrated database for Drosophila genomics
          GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
          iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
          InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
          KEGG Genes - Molecular building blocks of life in the genomic space.
          MIST (protein-protein) - An integrated Molecular Interaction Database
          modMine - A data warehouse for the modENCODE project
          Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
          Synonyms and Secondary IDs (14)
          Reported As
          Secondary FlyBase IDs
          • FBgn0036572
          Datasets (0)
          Study focus (0)
          Experimental Role
          Project
          Project Type
          Title
          References (141)