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Gene Dmel\phr

General Information
Symbol	Dmel\phr	Species	D. melanogaster
Name	photorepair	Annotation symbol	CG11205
Feature type	protein_coding_gene	FlyBase ID	FBgn0003082
Gene Model Status	Current	Stock availability	4 publicly available
Genomic Location
Chromosome (arm)	2R	Recombination map	2-56.8
Cytogenetic map	43E18-43E18	Sequence location	2R:3,712,794..3,714,824 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene photorepair is referred to in FlyBase by the symbol Dmel\phr (CG11205, FBgn0003082). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: deoxyribodipyrimidine photo-lyase activity. Based on sequence similarity, it is predicted to be involved in the biological process: DNA repair. 7 alleles are reported. No phenotypic data is available. It has 2 annotated transcripts and 2 annotated polypeptides. Protein features are: DNA photolyase, FAD-binding/Cryptochrome, C-terminal; DNA photolyase, N-terminal; DNA photolyase, class 2; Rossmann-like alpha/beta/alpha sandwich fold. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of low expression. Peak expression observed within 00-12 hour embryonic stages, in adult female stages. Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: larval/adult central nervous system, adult ovary. Comments on Affy2 ProbeSet: ProbeSet 1630728_a_at completely aligns to an exonic region common to each of the 2 FlyBase-annotated transcript isoforms of phr. Gene sequence location is 2R:3712794..3714824.
User Contributed Data
	Beta version, feedback welcome
Phenotypic Description from the Red Book (Lindsley & Zimm 1992)
Gene/Allele symbols may differ from current usage	phr: photorepair Deficient in photorepair of pyrimidine dimers; partially deficient in excision repair. Since phr/phr larvae show little or no photoreactivation after exposure to short wavelength UV light, the phr+ function is thought to play a significant role in UV resistance.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 43E18-43E18   Limits computationally determined from genome sequence between P{EP}CanB2EP774 and P{lacW}lin19k01207&P{lacW}rnh1k07624
Experimentally Determined Cytological Location
Cytogenetic map Notes References 44C-44D   (determined by in situ hybridisation)   (Todo et al., 1994) 43B-43C     (Hardin and Wensink, 1991)
Experimentally Determined Recombination Data
Location	2-56.8 (Boyd and Harris, 1987)
Left of (cM)	c (Boyd and Harris, 1985, Boyd and Harris, 1987)
Right of (cM)	pr (Boyd and Harris, 1985, Boyd and Harris, 1987)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\phr for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Low-frequency RNA-Seq exon junction(s) not annotated. Gene model reviewed during 5.49
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) phr-RA FBtr0088838  NM_078929   1915   555 phr-RB FBtr0088839  NM_165564   1737   535
Additional Transcript Data & Comments
Reported size (kB)	2.070 (longest cDNA) (Yasui et al., 1994)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein phr-PA   FBpp0087914   63.7   555   9.21     NP_523653   AAF59185 phr-PB   FBpp0087915   61.4   535   9.13     NP_724613   AAM68868
Additional Polypeptide Data & Comments
Reported size (kDa)	640 (aa); 74 (kD predicted) (Yasui et al., 1994)
Comments	Proteins of 555 amino acids (64kD) or 535 amino acids (61kD) may be produced if downstream AUGs are utilized. The actual start codon remains to be determined. Photoreactivating activity was observed from phr protein expressed in E. coli. (Yasui et al., 1994)
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • DNA photolyase, FAD-binding/Cryptochrome, C-terminal (IPR005101) DNA photolyase, N-terminal (IPR006050) DNA photolyase, class 2 (IPR008148) Rossmann-like alpha/beta/alpha sandwich fold (IPR014729)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA141185   AA246901   AA439623   AA801839   AE013599 AAF59185   AE013599 AAM68868   AY084133 AAL89871   BF490724   BI163188   BI215000   BI234752   BI236077   BP557339   CK604425   CK604426   CK604449   CK604450   CK604557   CK604558   CO294302   D26021 BAA05042   D26136   EC086879   EC212121   EC231950   EC243647   EL878620   EL878799   EL878895   EV579042   EV591432   EV596451   GH741385   GH741765   GH742320   GH742461   GH743933   GH744954   GH761409   GH762980   GH763233   GH765443   GH767034   GH767196   GH768577   GH769536   S73530 AAB32328
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q7JY97 A1Z757 Q24443 Q26373
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: larval/adult central nervous system, adult ovary. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    129.9 Larval Midgut    37.9 Larval Hindgut    53 Larval Malpighian Tubules    50.1 Larval Fat Body    38.1 Larval Salivary Gland    48 Larval Trachea    68.05 Larval Carcass    50.55 Adult Head    54.8 Adult Eye    70.8 Adult Brain    128.5 Adult Thoracic-Abdominal Ganglion    99.6 Adult Crop    76.8 Adult Midgut    28.6 Adult Hindgut    57 Adult Malpighian Tubules    55.9 Adult Fat Body    40.8 Adult Salivary Gland    63.5 Adult Heart    64.3 Adult VirginFemale Spermatheca    17.7 Adult InseminatedFemale Spermatheca    17.5 Adult Ovary    148.3 Adult Testis    33.7 Adult Male Accessory Gland    65.6 Adult Carcass    41.4 Expression Level Scale  None   Low   Moderate  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    129.9 Larval Midgut    37.9 Larval Hindgut    53 Larval Malpighian Tubules    50.1 Larval Fat Body    38.1 Larval Salivary Gland    48 Larval Trachea    68.05 Larval Carcass    50.55 Adult Head    54.8 Adult Eye    70.8 Adult Brain    128.5 Adult Thoracic-Abdominal Ganglion    99.6 Adult Crop    76.8 Adult Midgut    28.6 Adult Hindgut    57 Adult Malpighian Tubules    55.9 Adult Fat Body    40.8 Adult Salivary Gland    63.5 Adult Heart    64.3 Adult VirginFemale Spermatheca    17.7 Adult InseminatedFemale Spermatheca    17.5 Adult Ovary    148.3 Adult Testis    33.7 Adult Male Accessory Gland    65.6 Adult Carcass    41.4 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    129.9 Larval Midgut    37.9 Larval Hindgut    53 Larval Malpighian Tubules    50.1 Larval Fat Body    38.1 Larval Salivary Gland    48 Larval Trachea    68.05 Larval Carcass    50.55 Adult Head    54.8 Adult Eye    70.8 Adult Brain    128.5 Adult Thoracic-Abdominal Ganglion    99.6 Adult Crop    76.8 Adult Midgut    28.6 Adult Hindgut    57 Adult Malpighian Tubules    55.9 Adult Fat Body    40.8 Adult Salivary Gland    63.5 Adult Heart    64.3 Adult VirginFemale Spermatheca    17.7 Adult InseminatedFemale Spermatheca    17.5 Adult Ovary    148.3 Adult Testis    33.7 Adult Male Accessory Gland    65.6 Adult Carcass    41.4 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    129.9 Larval Midgut    37.9 Larval Hindgut    53 Larval Malpighian Tubules    50.1 Larval Fat Body    38.1 Larval Salivary Gland    48 Larval Trachea    68.05 Larval Carcass    50.55 Adult Head    54.8 Adult Eye    70.8 Adult Brain    128.5 Adult Thoracic-Abdominal Ganglion    99.6 Adult Crop    76.8 Adult Midgut    28.6 Adult Hindgut    57 Adult Malpighian Tubules    55.9 Adult Fat Body    40.8 Adult Salivary Gland    63.5 Adult Heart    64.3 Adult VirginFemale Spermatheca    17.7 Adult InseminatedFemale Spermatheca    17.5 Adult Ovary    148.3 Adult Testis    33.7 Adult Male Accessory Gland    65.6 Adult Carcass    41.4 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    129.9 Larval Midgut    37.9 Larval Hindgut    53 Larval Malpighian Tubules    50.1 Larval Fat Body    38.1 Larval Salivary Gland    48 Larval Trachea    68.05 Larval Carcass    50.55 Adult Head    54.8 Adult Eye    70.8 Adult Brain    128.5 Adult Thoracic-Abdominal Ganglion    99.6 Adult Crop    76.8 Adult Midgut    28.6 Adult Hindgut    57 Adult Malpighian Tubules    55.9 Adult Fat Body    40.8 Adult Salivary Gland    63.5 Adult Heart    64.3 Adult VirginFemale Spermatheca    17.7 Adult InseminatedFemale Spermatheca    17.5 Adult Ovary    148.3 Adult Testis    33.7 Adult Male Accessory Gland    65.6 Adult Carcass    41.4 Expression Level Scale  None   Low   Moderate  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    129.9 Larval Midgut    37.9 Larval Hindgut    53 Larval Malpighian Tubules    50.1 Larval Fat Body    38.1 Larval Salivary Gland    48 Larval Trachea    68.05 Larval Carcass    50.55 Adult Head    54.8 Adult Eye    70.8 Adult Brain    128.5 Adult Thoracic-Abdominal Ganglion    99.6 Adult Crop    76.8 Adult Midgut    28.6 Adult Hindgut    57 Adult Malpighian Tubules    55.9 Adult Fat Body    40.8 Adult Salivary Gland    63.5 Adult Heart    64.3 Adult VirginFemale Spermatheca    17.7 Adult InseminatedFemale Spermatheca    17.5 Adult Ovary    148.3 Adult Testis    33.7 Adult Male Accessory Gland    65.6 Adult Carcass    41.4 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    129.9 Larval Midgut    37.9 Larval Hindgut    53 Larval Malpighian Tubules    50.1 Larval Fat Body    38.1 Larval Salivary Gland    48 Larval Trachea    68.05 Larval Carcass    50.55 Adult Head    54.8 Adult Eye    70.8 Adult Brain    128.5 Adult Thoracic-Abdominal Ganglion    99.6 Adult Crop    76.8 Adult Midgut    28.6 Adult Hindgut    57 Adult Malpighian Tubules    55.9 Adult Fat Body    40.8 Adult Salivary Gland    63.5 Adult Heart    64.3 Adult VirginFemale Spermatheca    17.7 Adult InseminatedFemale Spermatheca    17.5 Adult Ovary    148.3 Adult Testis    33.7 Adult Male Accessory Gland    65.6 Adult Carcass    41.4 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    129.9 Larval Midgut    37.9 Larval Hindgut    53 Larval Malpighian Tubules    50.1 Larval Fat Body    38.1 Larval Salivary Gland    48 Larval Trachea    68.05 Larval Carcass    50.55 Adult Head    54.8 Adult Eye    70.8 Adult Brain    128.5 Adult Thoracic-Abdominal Ganglion    99.6 Adult Crop    76.8 Adult Midgut    28.6 Adult Hindgut    57 Adult Malpighian Tubules    55.9 Adult Fat Body    40.8 Adult Salivary Gland    63.5 Adult Heart    64.3 Adult VirginFemale Spermatheca    17.7 Adult InseminatedFemale Spermatheca    17.5 Adult Ovary    148.3 Adult Testis    33.7 Adult Male Accessory Gland    65.6 Adult Carcass    41.4 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    54.8   NA  Eye    70.8   NA  Brain    128.5   129.9  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    99.6   NA  Crop    76.8   37.9  Midgut    28.6   53  Hindgut    57   50.1  Malpighian Tubules    55.9   38.1  Fat Body    40.8   48  Salivary Gland    63.5   NA  Heart    64.3   68.05  Trachea    NA   NA  VirginFemale Spermatheca    17.7   NA  InseminatedFemale Spermatheca    17.5   NA  Ovary    148.3   NA  Testis    33.7   NA  Male Accessory Gland    65.6   50.55  Carcass    41.4 FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    5 central nervous system, larvae L3    3 central nervous system, pupae P8    0 head, virgin 1-day female    0 head, virgin 4-day female    0 head, virgin 20-day female    0 head, mated 1-day female    0 head, mated 4-day female    0 head, mated 20-day female    0 head, mated 1-day male    0 head, mated 4-day male    1 head, mated 20-day male    0 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    1 digestive system, 1-day adult    0 digestive system, 4-day adult    1 digestive system, 20-day adult    1 fat body, larvae L3 wandering    0 fat body, white prepupae    1 fat body, pupae P8    0 carcass, larvae L3 wandering    3 carcass, 1-day adult    0 carcass, 4-day adult    1 carcass, 20-day adult    1 ovary, virgin 4-day female    14 ovary, mated 4-day female    11 testis, mated 4-day male    6 accessory gland, mated 4-day male    1 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    5 central nervous system, larvae L3    3 central nervous system, pupae P8    0 head, virgin 1-day female    0 head, virgin 4-day female    0 head, virgin 20-day female    0 head, mated 1-day female    0 head, mated 4-day female    0 head, mated 20-day female    0 head, mated 1-day male    0 head, mated 4-day male    1 head, mated 20-day male    0 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    1 digestive system, 1-day adult    0 digestive system, 4-day adult    1 digestive system, 20-day adult    1 fat body, larvae L3 wandering    0 fat body, white prepupae    1 fat body, pupae P8    0 carcass, larvae L3 wandering    3 carcass, 1-day adult    0 carcass, 4-day adult    1 carcass, 20-day adult    1 ovary, virgin 4-day female    14 ovary, mated 4-day female    11 testis, mated 4-day male    6 accessory gland, mated 4-day male    1 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    5 central nervous system, larvae L3    3 central nervous system, pupae P8    0 head, virgin 1-day female    0 head, virgin 4-day female    0 head, virgin 20-day female    0 head, mated 1-day female    0 head, mated 4-day female    0 head, mated 20-day female    0 head, mated 1-day male    0 head, mated 4-day male    1 head, mated 20-day male    0 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    1 digestive system, 1-day adult    0 digestive system, 4-day adult    1 digestive system, 20-day adult    1 fat body, larvae L3 wandering    0 fat body, white prepupae    1 fat body, pupae P8    0 carcass, larvae L3 wandering    3 carcass, 1-day adult    0 carcass, 4-day adult    1 carcass, 20-day adult    1 ovary, virgin 4-day female    14 ovary, mated 4-day female    11 testis, mated 4-day male    6 accessory gland, mated 4-day male    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    5 central nervous system, larvae L3    3 central nervous system, pupae P8    0 head, virgin 1-day female    0 head, virgin 4-day female    0 head, virgin 20-day female    0 head, mated 1-day female    0 head, mated 4-day female    0 head, mated 20-day female    0 head, mated 1-day male    0 head, mated 4-day male    1 head, mated 20-day male    0 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    1 digestive system, 1-day adult    0 digestive system, 4-day adult    1 digestive system, 20-day adult    1 fat body, larvae L3 wandering    0 fat body, white prepupae    1 fat body, pupae P8    0 carcass, larvae L3 wandering    3 carcass, 1-day adult    0 carcass, 4-day adult    1 carcass, 20-day adult    1 ovary, virgin 4-day female    14 ovary, mated 4-day female    11 testis, mated 4-day male    6 accessory gland, mated 4-day male    1 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    5 central nervous system, larvae L3    3 central nervous system, pupae P8    0 head, virgin 1-day female    0 head, virgin 4-day female    0 head, virgin 20-day female    0 head, mated 1-day female    0 head, mated 4-day female    0 head, mated 20-day female    0 head, mated 1-day male    0 head, mated 4-day male    1 head, mated 20-day male    0 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    1 digestive system, 1-day adult    0 digestive system, 4-day adult    1 digestive system, 20-day adult    1 fat body, larvae L3 wandering    0 fat body, white prepupae    1 fat body, pupae P8    0 carcass, larvae L3 wandering    3 carcass, 1-day adult    0 carcass, 4-day adult    1 carcass, 20-day adult    1 ovary, virgin 4-day female    14 ovary, mated 4-day female    11 testis, mated 4-day male    6 accessory gland, mated 4-day male    1 Expression Level Scale  Very low   Low   Moderate  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    5 central nervous system, larvae L3    3 central nervous system, pupae P8    0 head, virgin 1-day female    0 head, virgin 4-day female    0 head, virgin 20-day female    0 head, mated 1-day female    0 head, mated 4-day female    0 head, mated 20-day female    0 head, mated 1-day male    0 head, mated 4-day male    1 head, mated 20-day male    0 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    1 digestive system, 1-day adult    0 digestive system, 4-day adult    1 digestive system, 20-day adult    1 fat body, larvae L3 wandering    0 fat body, white prepupae    1 fat body, pupae P8    0 carcass, larvae L3 wandering    3 carcass, 1-day adult    0 carcass, 4-day adult    1 carcass, 20-day adult    1 ovary, virgin 4-day female    14 ovary, mated 4-day female    11 testis, mated 4-day male    6 accessory gland, mated 4-day male    1 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    5 central nervous system, larvae L3    3 central nervous system, pupae P8    0 head, virgin 1-day female    0 head, virgin 4-day female    0 head, virgin 20-day female    0 head, mated 1-day female    0 head, mated 4-day female    0 head, mated 20-day female    0 head, mated 1-day male    0 head, mated 4-day male    1 head, mated 20-day male    0 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    1 digestive system, 1-day adult    0 digestive system, 4-day adult    1 digestive system, 20-day adult    1 fat body, larvae L3 wandering    0 fat body, white prepupae    1 fat body, pupae P8    0 carcass, larvae L3 wandering    3 carcass, 1-day adult    0 carcass, 4-day adult    1 carcass, 20-day adult    1 ovary, virgin 4-day female    14 ovary, mated 4-day female    11 testis, mated 4-day male    6 accessory gland, mated 4-day male    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    5 central nervous system, larvae L3    3 central nervous system, pupae P8    0 head, virgin 1-day female    0 head, virgin 4-day female    0 head, virgin 20-day female    0 head, mated 1-day female    0 head, mated 4-day female    0 head, mated 20-day female    0 head, mated 1-day male    0 head, mated 4-day male    1 head, mated 20-day male    0 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    1 digestive system, 1-day adult    0 digestive system, 4-day adult    1 digestive system, 20-day adult    1 fat body, larvae L3 wandering    0 fat body, white prepupae    1 fat body, pupae P8    0 carcass, larvae L3 wandering    3 carcass, 1-day adult    0 carcass, 4-day adult    1 carcass, 20-day adult    1 ovary, virgin 4-day female    14 ovary, mated 4-day female    11 testis, mated 4-day male    6 accessory gland, mated 4-day male    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of low expression. Peak expression observed within 00-12 hour embryonic stages, in adult female stages. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    26 embryo 02-04hr    10 embryo 04-06hr    27 embryo 06-08hr    21 embryo 08-10hr    13 embryo 10-12hr    10 embryo 12-14hr    4 embryo 14-16hr    4 embryo 16-18hr    3 embryo 18-20hr    2 embryo 20-22hr    2 embryo 22-24hr    2 larva L1    4 larva L2    3 larva L3 12hr old    3 larva L3 puffstage 1-2    5 larva L3 puffstage 3-6    6 larva L3 puffstage 7-9    6 white prepupae new    5 white prepupae 12hr    9 white prepupae 24hr    7 pupae 2d postWPP    3 pupae 3d postWPP    2 pupae 4d postWPP    6 adult male 01day    4 adult male 05day    7 adult male 30day    3 adult female 01day    10 adult female 05day    17 adult female 30day    21 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  26 embryo 02-04hr    10 embryo 04-06hr  (27) embryo 06-08hr    21 embryo 08-10hr    13 embryo 10-12hr    10 embryo 12-14hr    4 embryo 14-16hr    4 embryo 16-18hr    3 embryo 18-20hr    2 embryo 20-22hr    2 embryo 22-24hr    2 larva L1    4 larva L2    3 larva L3 12hr old    3 larva L3 puffstage 1-2    5 larva L3 puffstage 3-6    6 larva L3 puffstage 7-9    6 white prepupae new    5 white prepupae 12hr    9 white prepupae 24hr    7 pupae 2d postWPP    3 pupae 3d postWPP    2 pupae 4d postWPP    6 adult male 01day    4 adult male 05day    7 adult male 30day    3 adult female 01day    10 adult female 05day    17 adult female 30day    21 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    26 embryo 02-04hr    10 embryo 04-06hr    27 embryo 06-08hr    21 embryo 08-10hr    13 embryo 10-12hr    10 embryo 12-14hr    4 embryo 14-16hr    4 embryo 16-18hr    3 embryo 18-20hr    2 embryo 20-22hr    2 embryo 22-24hr    2 larva L1    4 larva L2    3 larva L3 12hr old    3 larva L3 puffstage 1-2    5 larva L3 puffstage 3-6    6 larva L3 puffstage 7-9    6 white prepupae new    5 white prepupae 12hr    9 white prepupae 24hr    7 pupae 2d postWPP    3 pupae 3d postWPP    2 pupae 4d postWPP    6 adult male 01day    4 adult male 05day    7 adult male 30day    3 adult female 01day    10 adult female 05day    17 adult female 30day    21 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    26 embryo 02-04hr    10 embryo 04-06hr    27 embryo 06-08hr    21 embryo 08-10hr    13 embryo 10-12hr    10 embryo 12-14hr    4 embryo 14-16hr    4 embryo 16-18hr    3 embryo 18-20hr    2 embryo 20-22hr    2 embryo 22-24hr    2 larva L1    4 larva L2    3 larva L3 12hr old    3 larva L3 puffstage 1-2    5 larva L3 puffstage 3-6    6 larva L3 puffstage 7-9    6 white prepupae new    5 white prepupae 12hr    9 white prepupae 24hr    7 pupae 2d postWPP    3 pupae 3d postWPP    2 pupae 4d postWPP    6 adult male 01day    4 adult male 05day    7 adult male 30day    3 adult female 01day    10 adult female 05day    17 adult female 30day    21 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    26 embryo 02-04hr    10 embryo 04-06hr    27 embryo 06-08hr    21 embryo 08-10hr    13 embryo 10-12hr    10 embryo 12-14hr    4 embryo 14-16hr    4 embryo 16-18hr    3 embryo 18-20hr    2 embryo 20-22hr    2 embryo 22-24hr    2 larva L1    4 larva L2    3 larva L3 12hr old    3 larva L3 puffstage 1-2    5 larva L3 puffstage 3-6    6 larva L3 puffstage 7-9    6 white prepupae new    5 white prepupae 12hr    9 white prepupae 24hr    7 pupae 2d postWPP    3 pupae 3d postWPP    2 pupae 4d postWPP    6 adult male 01day    4 adult male 05day    7 adult male 30day    3 adult female 01day    10 adult female 05day    17 adult female 30day    21 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  26 embryo 02-04hr    10 embryo 04-06hr  27 embryo 06-08hr    21 embryo 08-10hr    13 embryo 10-12hr    10 embryo 12-14hr    4 embryo 14-16hr    4 embryo 16-18hr    3 embryo 18-20hr    2 embryo 20-22hr    2 embryo 22-24hr    2 larva L1    4 larva L2    3 larva L3 12hr old    3 larva L3 puffstage 1-2    5 larva L3 puffstage 3-6    6 larva L3 puffstage 7-9    6 white prepupae new    5 white prepupae 12hr    9 white prepupae 24hr    7 pupae 2d postWPP    3 pupae 3d postWPP    2 pupae 4d postWPP    6 adult male 01day    4 adult male 05day    7 adult male 30day    3 adult female 01day    10 adult female 05day    17 adult female 30day    21 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    26 embryo 02-04hr    10 embryo 04-06hr    27 embryo 06-08hr    21 embryo 08-10hr    13 embryo 10-12hr    10 embryo 12-14hr    4 embryo 14-16hr    4 embryo 16-18hr    3 embryo 18-20hr    2 embryo 20-22hr    2 embryo 22-24hr    2 larva L1    4 larva L2    3 larva L3 12hr old    3 larva L3 puffstage 1-2    5 larva L3 puffstage 3-6    6 larva L3 puffstage 7-9    6 white prepupae new    5 white prepupae 12hr    9 white prepupae 24hr    7 pupae 2d postWPP    3 pupae 3d postWPP    2 pupae 4d postWPP    6 adult male 01day    4 adult male 05day    7 adult male 30day    3 adult female 01day    10 adult female 05day    17 adult female 30day    21 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    26 embryo 02-04hr    10 embryo 04-06hr    27 embryo 06-08hr    21 embryo 08-10hr    13 embryo 10-12hr    10 embryo 12-14hr    4 embryo 14-16hr    4 embryo 16-18hr    3 embryo 18-20hr    2 embryo 20-22hr    2 embryo 22-24hr    2 larva L1    4 larva L2    3 larva L3 12hr old    3 larva L3 puffstage 1-2    5 larva L3 puffstage 3-6    6 larva L3 puffstage 7-9    6 white prepupae new    5 white prepupae 12hr    9 white prepupae 24hr    7 pupae 2d postWPP    3 pupae 3d postWPP    2 pupae 4d postWPP    6 adult male 01day    4 adult male 05day    7 adult male 30day    3 adult female 01day    10 adult female 05day    17 adult female 30day    21 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    33 Schneider line 2 Sg4    12 embryonic 1182-4H    7 embryonic GM2    23 embryonic Kc167    26 embryonic S1    22 embryonic S3    17 leg disc CME L1    6 wing disc CME-W2    7 wing disc ML-DmD8    8 wing disc ML-DmD9    10 wing disc ML-DmD16-c3    7 wing disc ML-DmD21    19 wing disc ML-DmD32    8 haltere disc ML-DmD17-c3    12 eye-antennal disc ML-DmD11    5 antennal disc ML-DmD20-c5    15 mixed discs ML-DmD4-c1    7 CNS ML-DmBG1-c1    8 CNS ML-DmBG2-c2    8 tumorous blood cells mbn2    11 ovary fGS/OSS    26 ovary OSC    14 ovary OSS    2 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (33) Schneider line 2 Sg4    12 embryonic 1182-4H    7 embryonic GM2    23 embryonic Kc167  26 embryonic S1    22 embryonic S3    17 leg disc CME L1    6 wing disc CME-W2    7 wing disc ML-DmD8    8 wing disc ML-DmD9    10 wing disc ML-DmD16-c3    7 wing disc ML-DmD21    19 wing disc ML-DmD32    8 haltere disc ML-DmD17-c3    12 eye-antennal disc ML-DmD11    5 antennal disc ML-DmD20-c5    15 mixed discs ML-DmD4-c1    7 CNS ML-DmBG1-c1    8 CNS ML-DmBG2-c2    8 tumorous blood cells mbn2    11 ovary fGS/OSS  26 ovary OSC    14 ovary OSS    2 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    33 Schneider line 2 Sg4    12 embryonic 1182-4H    7 embryonic GM2    23 embryonic Kc167    26 embryonic S1    22 embryonic S3    17 leg disc CME L1    6 wing disc CME-W2    7 wing disc ML-DmD8    8 wing disc ML-DmD9    10 wing disc ML-DmD16-c3    7 wing disc ML-DmD21    19 wing disc ML-DmD32    8 haltere disc ML-DmD17-c3    12 eye-antennal disc ML-DmD11    5 antennal disc ML-DmD20-c5    15 mixed discs ML-DmD4-c1    7 CNS ML-DmBG1-c1    8 CNS ML-DmBG2-c2    8 tumorous blood cells mbn2    11 ovary fGS/OSS    26 ovary OSC    14 ovary OSS    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    33 Schneider line 2 Sg4    12 embryonic 1182-4H    7 embryonic GM2    23 embryonic Kc167    26 embryonic S1    22 embryonic S3    17 leg disc CME L1    6 wing disc CME-W2    7 wing disc ML-DmD8    8 wing disc ML-DmD9    10 wing disc ML-DmD16-c3    7 wing disc ML-DmD21    19 wing disc ML-DmD32    8 haltere disc ML-DmD17-c3    12 eye-antennal disc ML-DmD11    5 antennal disc ML-DmD20-c5    15 mixed discs ML-DmD4-c1    7 CNS ML-DmBG1-c1    8 CNS ML-DmBG2-c2    8 tumorous blood cells mbn2    11 ovary fGS/OSS    26 ovary OSC    14 ovary OSS    2 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    33 Schneider line 2 Sg4    12 embryonic 1182-4H    7 embryonic GM2    23 embryonic Kc167    26 embryonic S1    22 embryonic S3    17 leg disc CME L1    6 wing disc CME-W2    7 wing disc ML-DmD8    8 wing disc ML-DmD9    10 wing disc ML-DmD16-c3    7 wing disc ML-DmD21    19 wing disc ML-DmD32    8 haltere disc ML-DmD17-c3    12 eye-antennal disc ML-DmD11    5 antennal disc ML-DmD20-c5    15 mixed discs ML-DmD4-c1    7 CNS ML-DmBG1-c1    8 CNS ML-DmBG2-c2    8 tumorous blood cells mbn2    11 ovary fGS/OSS    26 ovary OSC    14 ovary OSS    2 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (33) Schneider line 2 Sg4    12 embryonic 1182-4H    7 embryonic GM2    23 embryonic Kc167  26 embryonic S1    22 embryonic S3    17 leg disc CME L1    6 wing disc CME-W2    7 wing disc ML-DmD8    8 wing disc ML-DmD9    10 wing disc ML-DmD16-c3    7 wing disc ML-DmD21    19 wing disc ML-DmD32    8 haltere disc ML-DmD17-c3    12 eye-antennal disc ML-DmD11    5 antennal disc ML-DmD20-c5    15 mixed discs ML-DmD4-c1    7 CNS ML-DmBG1-c1    8 CNS ML-DmBG2-c2    8 tumorous blood cells mbn2    11 ovary fGS/OSS  26 ovary OSC    14 ovary OSS    2 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    33 Schneider line 2 Sg4    12 embryonic 1182-4H    7 embryonic GM2    23 embryonic Kc167    26 embryonic S1    22 embryonic S3    17 leg disc CME L1    6 wing disc CME-W2    7 wing disc ML-DmD8    8 wing disc ML-DmD9    10 wing disc ML-DmD16-c3    7 wing disc ML-DmD21    19 wing disc ML-DmD32    8 haltere disc ML-DmD17-c3    12 eye-antennal disc ML-DmD11    5 antennal disc ML-DmD20-c5    15 mixed discs ML-DmD4-c1    7 CNS ML-DmBG1-c1    8 CNS ML-DmBG2-c2    8 tumorous blood cells mbn2    11 ovary fGS/OSS    26 ovary OSC    14 ovary OSS    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    33 Schneider line 2 Sg4    12 embryonic 1182-4H    7 embryonic GM2    23 embryonic Kc167    26 embryonic S1    22 embryonic S3    17 leg disc CME L1    6 wing disc CME-W2    7 wing disc ML-DmD8    8 wing disc ML-DmD9    10 wing disc ML-DmD16-c3    7 wing disc ML-DmD21    19 wing disc ML-DmD32    8 haltere disc ML-DmD17-c3    12 eye-antennal disc ML-DmD11    5 antennal disc ML-DmD20-c5    15 mixed discs ML-DmD4-c1    7 CNS ML-DmBG1-c1    8 CNS ML-DmBG2-c2    8 tumorous blood cells mbn2    11 ovary fGS/OSS    26 ovary OSC    14 ovary OSS    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    2 cold shock, 4-day adult    1 heat shock, 4-day adult    7 Cadmium 50 mM 6 hrs, larvae L3    4 Cadmium 50 mM 12 hrs, larvae L3    5 Cadmium 50 mM 48 hrs, 4-day adult    6 Cadmium 100 mM 48 hrs, 4-day adult    9 Copper 0.5 mM 12 hrs, larvae L3    3 Copper 15 mM 48 hrs, 4-day adult    3 Zinc 5 mM 12 hrs, larvae L3    2 Zinc 4.5 mM 48 hrs, 4-day adult    3 Ethanol 2.5% 3 hrs, larvae L3    17 Ethanol 5% 3 hrs, larvae L3    4 Ethanol 10% 3 hrs, larvae L3    4 Caffeine 1.5 mg/ml 4 hrs, larvae L3    5 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    14 Caffeine 25 mg/ml 48 hrs, 4-day adult    4 Paraquat 5 mM 48 hrs, 4-day adult    12 Paraquat 10 mM 48 hrs, 4-day adult    9 Rotenone 2 μg 12 hrs, larvae L3    3 Rotenone 8 μg 12 hrs, larvae L3    4 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    2 cold shock, 4-day adult    1 heat shock, 4-day adult    7 Cadmium 50 mM 6 hrs, larvae L3    4 Cadmium 50 mM 12 hrs, larvae L3    5 Cadmium 50 mM 48 hrs, 4-day adult    6 Cadmium 100 mM 48 hrs, 4-day adult    9 Copper 0.5 mM 12 hrs, larvae L3    3 Copper 15 mM 48 hrs, 4-day adult    3 Zinc 5 mM 12 hrs, larvae L3    2 Zinc 4.5 mM 48 hrs, 4-day adult    3 Ethanol 2.5% 3 hrs, larvae L3    17 Ethanol 5% 3 hrs, larvae L3    4 Ethanol 10% 3 hrs, larvae L3    4 Caffeine 1.5 mg/ml 4 hrs, larvae L3    5 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    14 Caffeine 25 mg/ml 48 hrs, 4-day adult    4 Paraquat 5 mM 48 hrs, 4-day adult    12 Paraquat 10 mM 48 hrs, 4-day adult    9 Rotenone 2 μg 12 hrs, larvae L3    3 Rotenone 8 μg 12 hrs, larvae L3    4 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    2 cold shock, 4-day adult    1 heat shock, 4-day adult    7 Cadmium 50 mM 6 hrs, larvae L3    4 Cadmium 50 mM 12 hrs, larvae L3    5 Cadmium 50 mM 48 hrs, 4-day adult    6 Cadmium 100 mM 48 hrs, 4-day adult    9 Copper 0.5 mM 12 hrs, larvae L3    3 Copper 15 mM 48 hrs, 4-day adult    3 Zinc 5 mM 12 hrs, larvae L3    2 Zinc 4.5 mM 48 hrs, 4-day adult    3 Ethanol 2.5% 3 hrs, larvae L3    17 Ethanol 5% 3 hrs, larvae L3    4 Ethanol 10% 3 hrs, larvae L3    4 Caffeine 1.5 mg/ml 4 hrs, larvae L3    5 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    14 Caffeine 25 mg/ml 48 hrs, 4-day adult    4 Paraquat 5 mM 48 hrs, 4-day adult    12 Paraquat 10 mM 48 hrs, 4-day adult    9 Rotenone 2 μg 12 hrs, larvae L3    3 Rotenone 8 μg 12 hrs, larvae L3    4 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    2 cold shock, 4-day adult    1 heat shock, 4-day adult    7 Cadmium 50 mM 6 hrs, larvae L3    4 Cadmium 50 mM 12 hrs, larvae L3    5 Cadmium 50 mM 48 hrs, 4-day adult    6 Cadmium 100 mM 48 hrs, 4-day adult    9 Copper 0.5 mM 12 hrs, larvae L3    3 Copper 15 mM 48 hrs, 4-day adult    3 Zinc 5 mM 12 hrs, larvae L3    2 Zinc 4.5 mM 48 hrs, 4-day adult    3 Ethanol 2.5% 3 hrs, larvae L3    17 Ethanol 5% 3 hrs, larvae L3    4 Ethanol 10% 3 hrs, larvae L3    4 Caffeine 1.5 mg/ml 4 hrs, larvae L3    5 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    14 Caffeine 25 mg/ml 48 hrs, 4-day adult    4 Paraquat 5 mM 48 hrs, 4-day adult    12 Paraquat 10 mM 48 hrs, 4-day adult    9 Rotenone 2 μg 12 hrs, larvae L3    3 Rotenone 8 μg 12 hrs, larvae L3    4 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    2 cold shock, 4-day adult    1 heat shock, 4-day adult    7 Cadmium 50 mM 6 hrs, larvae L3    4 Cadmium 50 mM 12 hrs, larvae L3    5 Cadmium 50 mM 48 hrs, 4-day adult    6 Cadmium 100 mM 48 hrs, 4-day adult    9 Copper 0.5 mM 12 hrs, larvae L3    3 Copper 15 mM 48 hrs, 4-day adult    3 Zinc 5 mM 12 hrs, larvae L3    2 Zinc 4.5 mM 48 hrs, 4-day adult    3 Ethanol 2.5% 3 hrs, larvae L3    17 Ethanol 5% 3 hrs, larvae L3    4 Ethanol 10% 3 hrs, larvae L3    4 Caffeine 1.5 mg/ml 4 hrs, larvae L3    5 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    14 Caffeine 25 mg/ml 48 hrs, 4-day adult    4 Paraquat 5 mM 48 hrs, 4-day adult    12 Paraquat 10 mM 48 hrs, 4-day adult    9 Rotenone 2 μg 12 hrs, larvae L3    3 Rotenone 8 μg 12 hrs, larvae L3    4 Expression Level Scale  Very low   Low   Moderate  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    2 cold shock, 4-day adult    1 heat shock, 4-day adult    7 Cadmium 50 mM 6 hrs, larvae L3    4 Cadmium 50 mM 12 hrs, larvae L3    5 Cadmium 50 mM 48 hrs, 4-day adult    6 Cadmium 100 mM 48 hrs, 4-day adult    9 Copper 0.5 mM 12 hrs, larvae L3    3 Copper 15 mM 48 hrs, 4-day adult    3 Zinc 5 mM 12 hrs, larvae L3    2 Zinc 4.5 mM 48 hrs, 4-day adult    3 Ethanol 2.5% 3 hrs, larvae L3    17 Ethanol 5% 3 hrs, larvae L3    4 Ethanol 10% 3 hrs, larvae L3    4 Caffeine 1.5 mg/ml 4 hrs, larvae L3    5 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    14 Caffeine 25 mg/ml 48 hrs, 4-day adult    4 Paraquat 5 mM 48 hrs, 4-day adult    12 Paraquat 10 mM 48 hrs, 4-day adult    9 Rotenone 2 μg 12 hrs, larvae L3    3 Rotenone 8 μg 12 hrs, larvae L3    4 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    2 cold shock, 4-day adult    1 heat shock, 4-day adult    7 Cadmium 50 mM 6 hrs, larvae L3    4 Cadmium 50 mM 12 hrs, larvae L3    5 Cadmium 50 mM 48 hrs, 4-day adult    6 Cadmium 100 mM 48 hrs, 4-day adult    9 Copper 0.5 mM 12 hrs, larvae L3    3 Copper 15 mM 48 hrs, 4-day adult    3 Zinc 5 mM 12 hrs, larvae L3    2 Zinc 4.5 mM 48 hrs, 4-day adult    3 Ethanol 2.5% 3 hrs, larvae L3    17 Ethanol 5% 3 hrs, larvae L3    4 Ethanol 10% 3 hrs, larvae L3    4 Caffeine 1.5 mg/ml 4 hrs, larvae L3    5 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    14 Caffeine 25 mg/ml 48 hrs, 4-day adult    4 Paraquat 5 mM 48 hrs, 4-day adult    12 Paraquat 10 mM 48 hrs, 4-day adult    9 Rotenone 2 μg 12 hrs, larvae L3    3 Rotenone 8 μg 12 hrs, larvae L3    4 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    2 cold shock, 4-day adult    1 heat shock, 4-day adult    7 Cadmium 50 mM 6 hrs, larvae L3    4 Cadmium 50 mM 12 hrs, larvae L3    5 Cadmium 50 mM 48 hrs, 4-day adult    6 Cadmium 100 mM 48 hrs, 4-day adult    9 Copper 0.5 mM 12 hrs, larvae L3    3 Copper 15 mM 48 hrs, 4-day adult    3 Zinc 5 mM 12 hrs, larvae L3    2 Zinc 4.5 mM 48 hrs, 4-day adult    3 Ethanol 2.5% 3 hrs, larvae L3    17 Ethanol 5% 3 hrs, larvae L3    4 Ethanol 10% 3 hrs, larvae L3    4 Caffeine 1.5 mg/ml 4 hrs, larvae L3    5 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    14 Caffeine 25 mg/ml 48 hrs, 4-day adult    4 Paraquat 5 mM 48 hrs, 4-day adult    12 Paraquat 10 mM 48 hrs, 4-day adult    9 Rotenone 2 μg 12 hrs, larvae L3    3 Rotenone 8 μg 12 hrs, larvae L3    4 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010, Graveley et al., 2011) mE2_34_mRNA_expression_cluster_06 mE1_20_mRNA_expression_cluster_06
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0003082 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG11205-RA;CG11205-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele viable, with Scer\GAL4pnr-MD237 phrGD12620 Other Phenotypes Allele DNA repair defective phr1 phrmus304-D3 phrmus306-D1 phrmus308-D2 Phenotype manifest in Allele
Classical Alleles ( 5 )
For All Classical Alleles Show
Allele of phr Class Mutagen Stocks Known lesion phrmus306-D1 1 -- phr1 spontaneous 0 -- phrmus304-D3 0 -- phrmus308-D2 0 -- phrunspecified 0 --
Alleles Carried on Transgenic Constructs ( 2 )
For All Alleles Carried on Transgenic Constructs Show
Allele of phr Class Mutagen Stocks Known lesion phrGD12620 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes phrJF02755 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes
Aneuploid Aberrations
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD12620} NA P{GD17778} NA P{TRiP.JF02755} NA
Insertions
	Type of insertions Name Expression data
Gene Ontology: Function, Process & Cellular Component ( 2 unique terms )
Terms Based on Experimental Evidence ( 0 terms )
Terms Based on Predictions or Assertions ( 2 terms )
Molecular Function
CV term Evidence References
deoxyribodipyrimidine photo-lyase activity inferred from sequence or structural similarity with UniProtKB:Q28464 (FlyBase, 1992-) non-traceable author statement (Yasui, 1993.11.26)
Biological Process
CV term Evidence References
DNA repair inferred from sequence or structural similarity with UniProtKB:Q28464 (FlyBase, 1992-)
Cellular Component ( 0 terms)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
protein-protein
Interacting group Assay References
phr - CG10077 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) phr - CG11107 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) phr - CG3817 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) phr - Cdc5 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) phr - mTerf3 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23)
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions phr allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 61601 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0003082 DroID - A comprehensive database of gene and protein interactions. • FBgn0003082 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 35735
Orthologs
OrthoDB Orthologs (25) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG6PCBBT Dipteran inclusive ortholog search EOG6001SP Insect inclusive ortholog search EOG6X0KNK Arthropod inclusive ortholog search EOG6CJSZB Metazoa inclusive ortholog search EOG6WHNCX
Orthologs in Drosophila Species (EOG6PCBBT)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\phr     Drosophila simulans   Dsim\GD10512 Y   Drosophila sechellia   Dsec\GM20985 Y   Drosophila erecta   Dere\GG23307 Y   Drosophila yakuba   Dyak\GE19152 Y   Drosophila ananassae   Dana\GF13637 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA10839 Y   Drosophila persimilis   Dper\GL17032 Y   Drosophila willistoni   Dwil\GK19412 Y   Drosophila virilis   Dvir\GJ17708 Y   Drosophila mojavensis   Dmoj\GI19782 Y   Drosophila grimshawi   Dgri\GH21292 Y
Orthologs in non-Drosophila Dipterans (EOG6001SP)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL001787   Anopheles gambiae Malaria mosquito  Agam\AGAP005052   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ003975
Orthologs in non-Dipteran Insects (EOG6X0KNK)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\phr   Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG015607   Acyrthosiphon pisum Pea aphid  Apim\ACYPI007301   Bombyx mori Silkmoth  Bmor\BGIBMGA003618
Orthologs in non-Insect Arthropods (EOG6CJSZB)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\cytb
Orthologs in non-Arthropod Metazoa (EOG6WHNCX)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_001597gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_024091gn Y Danio rerio Zebrafish  Drer\zgc:66475 Y Xenopus tropicalis Western clawed frog  Xtro\ENSXETG00000033241 Y Gallus gallus Domestic chicken  Ggal\LOC424919 Y
Human Orthologs (0)
Gene OMIM HGNC
AAA Orthologs (11) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD10512 Drosophila sechellia Dsec\GM20985 Drosophila erecta Dere\GG23307 Drosophila yakuba Dyak\GE19152 Drosophila ananassae Dana\GF13637 Drosophila pseudoobscura pseudoobscura Dpse\GA10839 Drosophila persimilis Dper\GL17032 Drosophila willistoni Dwil\GK19412 Drosophila virilis Dvir\GJ17708 Drosophila mojavensis Dmoj\GI19782 Drosophila grimshawi Dgri\GH21292
Stocks & Reagents
Stocks Listed in FlyBase ( 4 )
Bloomington	7046 phrmus306-D1 27676 y1 v1; P{TRiP.JF02755}attP2/TM3, Sb1
VDRC	v35497 w1118; P{GD12620}v35497 v35499 w1118; P{GD12620}v35499
Genomic Clones ( 1 )
	BACR04B09 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 39 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	RE21178
Other clones	DPiM_RE21178
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	AT27284 GM03463 LD05911 LD14237 RE02527 RE30507 RE32073
Other clones	2196 65772 76446 CK01.142A.H4 CK01599 Dmel_dig_005307_0612_1630 Dmel_neb_000852_0435_3620 Dmel_neb_015376_0944_1771 EK206526 FGM308G04 IP08452 IP08652 IP08752 RP01013 RP001015152 RP001016062 RP001019906 RP001021140 RP001021955 RP001023080 RP001034401 RP001037550 RP001039812 RP001040519 RP001041057 RP001041904 RP001042195 UT01177 UT01191 UT01277
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0003082 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 35735
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of	Source for merge of: phr anon-OV1 (Bayraktaroglu, 2000.11.2)
Additional comments	CG18853 appears to be a chimeric gene, with the 5' part of the gene derived from CG12822 and the 3' part of the gene derived from phr. (Rogers and Hartl, 2012) "CG18853" is a putative chimeric gene derived from the "CG12822" and "phr" genes (where coding sequences of the two parental genes contribute to the coding sequence of the chimeric gene). (Rogers et al., 2009)
Other Comments
	Gene is involved in pre-replication DNA repair of UV and AA lesions and photorepair. (de Buendia, 1998) Biochemical and photochemical characterisation of purified phr. Studies reveal the protein belongs to the folate class of enzymes. (Kim et al., 1996) Drosophila have two types of photolyase, the substrate of each photolyase is completely different. Photolyase repairs UV induced DNA damage, the two types of DNA damage are cyclobutane pyrimidine dimer (CPD) and (6-4) photoproduct. phr encodes the photolyase that specifically repairs CPD. (Todo, 1996.4.30) phr encodes the apoenzyme of DNA photolyase. (Todo et al., 1994) Transformation of E.coli SY2 cells with phr provides photoreactivity and increases survival of cells on illumination with visible light after UV irradiation. (Yasui et al., 1994) phr gene product preferentially binds to unusual DNA structures and is UV inducible. (Hardin and Wensink, 1991) Encodes a photolyase that repairs cyclobutane pyrimidine dimers induced by UV radiation of DNA.
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_078929 NM_165564 RefSeq (Proteins) • NP_523653 NP_724613 DDBJ / EMBL / GenBank • AAB32328 AAF59185 AAL89871 AAM68868 AY084133 BAA05042 BI215000 D26021 D26136 S73530 Entrez Gene - A searchable database of RefSeq genes. • 35735 UniProtKB/TrEMBL • A1Z757 Q7JY97 Q24443 Q26373
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • DNA photolyase, FAD-binding/Cryptochrome, C-terminal (IPR005101) DNA photolyase, N-terminal (IPR006050) DNA photolyase, class 2 (IPR008148) Rossmann-like alpha/beta/alpha sandwich fold (IPR014729)
Linkouts
	BioGRID - A database of protein and genetic interactions • 61601 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0003082 DroID - A comprehensive database of gene and protein interactions. • FBgn0003082 DRSC - Results from RNAi screens. • FBgn0003082 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0003082 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG11205-RA;CG11205-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0003082 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 35735 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 35735 modMine - Data generated by the modENCODE project. • FBgn0003082
Synonyms & Secondary IDs ( 14 )
Reported As
Symbol Synonym	anonOV1   anon-OV1   C2PHR (Kanai et al., 1997) CG11205 (Rogers and Hartl, 2012, Perkins et al., 2009, Zhan et al., 2011) CG11205-PA (Rogers et al., 2009) Dm CPD (Todo, 1999) Phl   phr (Zraly et al., 2006, Rogers et al., 2009, Fernández-Ayala et al., 2010)
Name Synonym	anonymous ovarian cDNA 1   CPD photolyase   DNA photolyase (Yasui et al., 1994) photolyase (Yasui, 1993.11.26) Photolyase   photorepair (Harbison et al., 2005, Fernández-Ayala et al., 2010)
Secondary FlyBase IDs
	FBgn0011299 FBgn0014003
References ( 43 )
Generate a list of	All references relating to this gene ( 43 )
List References by type	Research paper  ( 20 ) Supplementary material  ( 4 ) Review  ( 3 ) Personal communication to FlyBase  ( 7 ) Abstract  ( 2 ) FlyBase analysis  ( 1 ) DNA/RNA sequence record  ( 1 ) Curated genome annotation  ( 2 ) Book  ( 1 ) Stock list  ( 1 )
Recent research papers ( 3 )
	Rogers and Hartl, 2012, Mol. Biol. Evol. 29(2): 517--529 Chimeric Genes as a Source of Rapid Evolution in Drosophila melanogaster. [FBrf0217452] Selby and Sancar, 2012, Biochemistry 51(1): 167--171 The second chromophore in Drosophila photolyase/cryptochrome family photoreceptors. [FBrf0217122] Zhan et al., 2011, Gene 470(1-2): 1--6 Evolution of alternative splicing in newly evolved genes of Drosophila. [FBrf0212278] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2011 Show reviews ...