novel protein required for sister chromatid separation in mitosis - shares functional similarities to securin a protein that acts to premature activation of separins - securin inhibits separase endoprotease activity via an inhibitory pseudosubstrate region
Low-frequency RNA-Seq exon junction(s) not annotated.
Gene model reviewed during 5.45
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\pim using the Feature Mapper tool.
pim transcripts are detected in embryos, third instar larvae, and pupae. By in situ hybridization, pim transcripts are seen distributed throughout the embryo up to embyronic cycle 16. At later stages they become restricted to the developing nervous system and appear to be correlated with mitotic proliferation.
pim protein accumulates in the cytoplasm in interphase 14. Signals are present throughout the cell in prophase and metaphase 14, decrease in anaphase and are undetectable in telophase. pim protein also gradually accumulates during interphase and rapidly degrades during mitosis in later cell cycles.
GBrowse - Visual display of RNA-Seq signalsView Dmel\pim in GBrowse 2
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Five (unnamed) recessive lethal alleles have been isolated during a cytogenetic analysis of chromosomal region 31.