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Gene Dmel\pk

General Information
Symbol	Dmel\pk	Species	D. melanogaster
Name	prickle	Annotation symbol	CG11084
Feature type	protein_coding_gene	FlyBase ID	FBgn0003090
Gene Model Status	Current	Stock availability	47 publicly available
Also Known As	sple, pk-sple
Genomic Location
Chromosome (arm)	2R	Recombination map	2-55.3
Cytogenetic map	42F3-43A1	Sequence location	2R:3,038,207..3,110,885 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene prickle is referred to in FlyBase by the symbol Dmel\pk (CG11084, FBgn0003090). It is a protein_coding_gene from Drosophila melanogaster. An electronic pipeline based on InterPro domains suggests that it has the molecular function: zinc ion binding. There is experimental evidence that it is involved in the biological process: establishment or maintenance of cell polarity; establishment of imaginal disc-derived wing hair orientation; establishment of ommatidial planar polarity; morphogenesis of a polarized epithelium. 102 alleles are reported. The phenotypes of these alleles are annotated with: adult segment; organ system subdivision; adult mesothoracic segment; thoracic segment; appendage segment; external compound sense organ; organ system; wing hair; compound cell cluster organ; metatarsus; integumentary specialisation; peripheral nervous system. It has 3 annotated transcripts and 3 annotated polypeptides. Protein features are: PET domain; Zinc finger, LIM-type. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of very low expression. Peak expression observed within 06-18 hour embryonic stages, at stages throughout the pupal period. Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: larval central nervous system. Comments on Affy2 ProbeSet: ProbeSet 1636612_a_at completely aligns to an exonic region common to each of the 3 FlyBase-annotated transcript isoforms of pk. Gene sequence location is 2R:3038207..3110885.
External Summaries
Phenotypic Description from the Red Book (Lindsley & Zimm 1992)
Gene/Allele symbols may differ from current usage	pk: prickle Polarity pattern of wing, haltere, and notum altered in mutants. Chaetae of triple row on anterior wing slanted anteriorly instead of posteriorly. Trichomes near L2 vein arranged in counterclockwise whorl on right wing blade, in clockwise whorl on left blade; trichomes in anterior wing occasionally duplicated (Gubb and Garcia-Bellido, 1982). On the notum, the posterior acrostichals are irregularly erect and whorled. Occasionally, extra dorsocentral and scutellar bristles appear at temperatures above 23. Mutant flies slightly larger than wild type. Gubb and Garcia-Bellido (1982) describe somatic clones of homozygous pk cells. sple: spiny legs Polarity of chaetae and trichomes on legs irregular; relations between bracts and bristles disrupted. High incidence of ectopic tarsal joints with inverted polarity, especially in tarsae 3 and 4; incomplete intersegmental membranes between tarsal segments, especially between segments 3 and 4; no extra sensilla companiformia despite extra joints. Chaetae on abdominal tergites turned toward midline instead of pointing posteriorly as in wild type; polarity of bristles on sternites disrupted as well. sple3 A low-temperature-sensitive allele. Legs of flies raised at 19 highly condensed with incomplete joints, haphazard bristle pattern, occasional increase in number of bristle rows, and absence of some prominent markers. Flies unable to walk and soon get stuck in food. In sple3 flies raised at 28 53% of legs, though apparently normal, display abnormalities such as swollen second, third, and fourth tarsal segments, abnormal tarsal joints and reversals in bristle orientation in the middle of every segment; such flies able to walk and breed. About 30% of legs show phenotype intermediate between the two phenotypes described above. Mutant phenotype expressed in the homeotic legs of Antp and ssa; also expressed in mitotic clones.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2011_10	References Matsubara et al., 2011, Genes Dev. 25(18): 1982--1996
FB2012_01	Sequence features HFA06178 BKN29294
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 42F3-43A1   Limits computationally determined from genome sequence between P{lacW}vimark16722 and P{lacW}cosk16101
Experimentally Determined Cytological Location
Cytogenetic map Notes References 43A1-43A2     (Gubb, 1999.7.5) 42E3-43C3   Placed in 42E3--43C3 by deficiency mapping. This cytological map position does not agree with FBrf0020044.   (Ashburner et al., 1981)
Experimentally Determined Recombination Data
Location	2-55.3 (Grau and Simpson, 1987, ) 2-56 (Ashburner et al., 1981) 2-53 (Craymer, 1980) 2-55 (Goldschmidt, 1944)
Left of (cM)	cn (Ashburner et al., 1981) pwn (Ashburner et al., 1981, Grau and Simpson, 1987)
Right of (cM)
Notes	Genetic map position is approximate. (Ashburner et al., 1981) Alleles of the 'prickle' phenotypic class map to the left of alleles of the 'sple' phenotypic class. (Grau and Simpson, 1987) The cellular polarity gene pk and the adult lethal nec gene map within the proximal region of pk-sple complex among a set of 3 Serpin transcripts. (Gubb and Green, 1995)
Gene Model & Products
Please see the GBrowse view of Dmel\pk for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Transposons inserted in two introns
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) pk-RA FBtr0089042  NM_165508   4244   963 pk-RB FBtr0089043  NM_165509   4093   1029 pk-RC FBtr0089044  NM_165512   5197   1299
Additional Transcript Data & Comments
Reported size (kB)	5.1, 4.2 (northern blot) (Gubb et al., 1999)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein pk-PA   FBpp0088113   104.7   963   7.23     NP_724534   AAM68908 pk-PB   FBpp0088114   111.8   1029   6.94     NP_724535   AAF59284 pk-PC   FBpp0088115   140.7   1299   6.87     NP_724538   AAF59281
Additional Polypeptide Data & Comments
Reported size (kDa)	1206, 936, 870 (aa) (Gubb et al., 1999)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Zinc finger, LIM-type (IPR001781) PET domain (IPR010442)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA141122   AA141456   AA141593   AA141714   AA141731   AA141885   AE013599 AAF59281   AE013599 AAF59284   AE013599 AAM68908   AI386899   AI533454   AI533463   AI534426   AI541728   AJ243708 CAB57344   AJ243709 CAB99211   AJ243710 CAB57345   AQ254872   BF489526   BF500862   BG637093   BG639736   BG640414   BI142092   BI358319   BI367893   BI368978   BI563870   BI571915   BI572060   BI572698   BI572705   BI572981   BI608966   BI616436   BI617142   BI619901   BI624204   BI632577   BI637740   BI637762   BI638345   BI639929   BT126167   BT126320   BT126321   CK134390   CO177549   CO178669   CO179410   CO179610   CO187077   CO188193   CO262294   CO265804   CO266528   CO268279   CO268775   CO268945   CO269956   CO270891   CO271243   CO271944   CO272166   CO272320   CO273023   CO273402   CO275031   CO275886   CO279733   CO280947   CO281268   CO281528   CO281603   CO281955   CO281956   CO284589   CO284981   CO286248   CO286446   CO291601   CO291625   CO292457   CO294915   CO295477   CO296503   CO299908   CO300848   CO303448   CO304688   CO304728   CO305638   CO309979   CO312884   CO314047   CO315692   CO316223   CO320331   CO321061   CO321607   CO327053   CO328882   CO329578   CO331136   CO331743   CO332242   CO333512   CO336331   CO339030   CO339033   CO339507   CO339724   CO340147   CO340901   CO340952   CO341425   CO341811   CO342049   CO342771   CO344644   CZ472184   CZ486664   CZ486665   CZ489851   DN154343   DQ017440 AAY82222   DQ017441 AAY82223   EC054349   EC205374   EC209673   EC220291   EC225092   EC249281   EC252343   EC254318   EC259329   EL870169   EL871054   ES693917   ES696173
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q3YNB2 A1Z6W3
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage   ventral midline   (Gubb et al., 1999) cephalic furrow   (Gubb et al., 1999) embryonic stage 8   cephalic furrow   (Gubb et al., 1999) embryonic stage 14   parasegmental furrow   (Gubb et al., 1999) larval stage   eye disc   (Gubb et al., 1999) imaginal disc   (Gubb et al., 1999) wing disc   (Gubb et al., 1999) third instar larval stage   morphogenetic furrow | posterior to   (Gubb et al., 1999) pupal stage P6 -- P7   leg   (Gubb et al., 1999) Comment:reference states 28-34 hr APF wing   (Gubb et al., 1999) Comment:reference states 28-34 hr APF
Additional Descriptive Data
	In 28-34hr pupal wings, pk transcripts are expressed uniformly in intervein cells but not in presumptive vein regions. In pupal legs, transcripts are uniform in most cells but are excluded from the segmental boundaries. Low levels are detected in restricted domains in larval imaginal discs. In the eye disc, expression is detected in a stripe of cells behind the morphogenetic furrow. In wing discs, expression is higher along the dorsoventral compartment boundary. In embryos, a dynamic expression pattern is observed. Expression is highest in cells engaged in morphogenetic movements such as invaginating midline cells, the cephalic fold, and at parasegmental boundaries. Expression of the "pk" and "sple" isoforms is indistinguishable. (Gubb et al., 1999) "pkM" transcripts are detected only in embryos. (Gubb et al., 1999)
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0003090    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0003090 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of very low expression. Peak expression observed within 06-18 hour embryonic stages, at stages throughout the pupal period. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0003090 expression level Developmental Stage   Expression Level embryo 00-02hr    47 embryo 02-04hr    59 embryo 04-06hr    63 embryo 06-08hr    489 embryo 08-10hr    1006 embryo 10-12hr    2021 embryo 12-14hr    1924 embryo 14-16hr    2762 embryo 16-18hr    1324 embryo 18-20hr    1114 embryo 20-22hr    618 embryo 22-24hr    516 larva L1    356 larva L2    244 larva L3 12hr old    157 larva L3 puffstage 1-2    202 larva L3 puffstage 3-6    488 larva L3 puffstage 7-9    535 white prepupae new    600 white prepupae 12hr    936 white prepupae 24hr    1490 pupae 2d postWPP    1533 pupae 3d postWPP    353 pupae 4d postWPP    852 adult male 01day    179 adult male 05day    166 adult male 30day    180 adult female 01day    186 adult female 05day    69 adult female 30day    74 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr    47 embryo 02-04hr    59 embryo 04-06hr    63 embryo 06-08hr  (489) embryo 08-10hr  (1006) embryo 10-12hr  (2021) embryo 12-14hr  (1924) embryo 14-16hr  (2762) embryo 16-18hr  (1324) embryo 18-20hr  (1114) embryo 20-22hr  (618) embryo 22-24hr  (516) larva L1  (356) larva L2  (244) larva L3 12hr old  (157) larva L3 puffstage 1-2  (202) larva L3 puffstage 3-6  (488) larva L3 puffstage 7-9  (535) white prepupae new  (600) white prepupae 12hr  (936) white prepupae 24hr  (1490) pupae 2d postWPP  (1533) pupae 3d postWPP  (353) pupae 4d postWPP  (852) adult male 01day  (179) adult male 05day  (166) adult male 30day  (180) adult female 01day  (186) adult female 05day    69 adult female 30day    74 Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    47 embryo 02-04hr    59 embryo 04-06hr    63 embryo 06-08hr    489 embryo 08-10hr    1006 embryo 10-12hr  (2021) embryo 12-14hr  (1924) embryo 14-16hr  (2762) embryo 16-18hr    1324 embryo 18-20hr    1114 embryo 20-22hr    618 embryo 22-24hr    516 larva L1    356 larva L2    244 larva L3 12hr old    157 larva L3 puffstage 1-2    202 larva L3 puffstage 3-6    488 larva L3 puffstage 7-9    535 white prepupae new    600 white prepupae 12hr    936 white prepupae 24hr  1490 pupae 2d postWPP  (1533) pupae 3d postWPP    353 pupae 4d postWPP    852 adult male 01day    179 adult male 05day    166 adult male 30day    180 adult female 01day    186 adult female 05day    69 adult female 30day    74 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    47 embryo 02-04hr    59 embryo 04-06hr    63 embryo 06-08hr    489 embryo 08-10hr    1006 embryo 10-12hr    2021 embryo 12-14hr    1924 embryo 14-16hr    2762 embryo 16-18hr    1324 embryo 18-20hr    1114 embryo 20-22hr    618 embryo 22-24hr    516 larva L1    356 larva L2    244 larva L3 12hr old    157 larva L3 puffstage 1-2    202 larva L3 puffstage 3-6    488 larva L3 puffstage 7-9    535 white prepupae new    600 white prepupae 12hr    936 white prepupae 24hr    1490 pupae 2d postWPP    1533 pupae 3d postWPP    353 pupae 4d postWPP    852 adult male 01day    179 adult male 05day    166 adult male 30day    180 adult female 01day    186 adult female 05day    69 adult female 30day    74 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    47 embryo 02-04hr    59 embryo 04-06hr    63 embryo 06-08hr    489 embryo 08-10hr    1006 embryo 10-12hr    2021 embryo 12-14hr    1924 embryo 14-16hr    2762 embryo 16-18hr    1324 embryo 18-20hr    1114 embryo 20-22hr    618 embryo 22-24hr    516 larva L1    356 larva L2    244 larva L3 12hr old    157 larva L3 puffstage 1-2    202 larva L3 puffstage 3-6    488 larva L3 puffstage 7-9    535 white prepupae new    600 white prepupae 12hr    936 white prepupae 24hr    1490 pupae 2d postWPP    1533 pupae 3d postWPP    353 pupae 4d postWPP    852 adult male 01day    179 adult male 05day    166 adult male 30day    180 adult female 01day    186 adult female 05day    69 adult female 30day    74 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0003090 expression level Developmental Stage   Expression Level embryo 00-02hr    47 embryo 02-04hr    59 embryo 04-06hr    63 embryo 06-08hr    489 embryo 08-10hr    1006 embryo 10-12hr    2021 embryo 12-14hr    1924 embryo 14-16hr    2762 embryo 16-18hr    1324 embryo 18-20hr    1114 embryo 20-22hr    618 embryo 22-24hr    516 larva L1    356 larva L2    244 larva L3 12hr old    157 larva L3 puffstage 1-2    202 larva L3 puffstage 3-6    488 larva L3 puffstage 7-9    535 white prepupae new    600 white prepupae 12hr    936 white prepupae 24hr    1490 pupae 2d postWPP    1533 pupae 3d postWPP    353 pupae 4d postWPP    852 adult male 01day    179 adult male 05day    166 adult male 30day    180 adult female 01day    186 adult female 05day    69 adult female 30day    74 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr    47 embryo 02-04hr    59 embryo 04-06hr    63 embryo 06-08hr  (489) embryo 08-10hr  (1006) embryo 10-12hr  (2021) embryo 12-14hr  (1924) embryo 14-16hr  (2762) embryo 16-18hr  (1324) embryo 18-20hr  (1114) embryo 20-22hr  (618) embryo 22-24hr  (516) larva L1  (356) larva L2  (244) larva L3 12hr old  (157) larva L3 puffstage 1-2  (202) larva L3 puffstage 3-6  (488) larva L3 puffstage 7-9  (535) white prepupae new  (600) white prepupae 12hr  (936) white prepupae 24hr  (1490) pupae 2d postWPP  (1533) pupae 3d postWPP  (353) pupae 4d postWPP  (852) adult male 01day  (179) adult male 05day  (166) adult male 30day  (180) adult female 01day  (186) adult female 05day    69 adult female 30day    74 Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    47 embryo 02-04hr    59 embryo 04-06hr    63 embryo 06-08hr    489 embryo 08-10hr    1006 embryo 10-12hr  2021 embryo 12-14hr  1924 embryo 14-16hr  (2762) embryo 16-18hr    1324 embryo 18-20hr    1114 embryo 20-22hr    618 embryo 22-24hr    516 larva L1    356 larva L2    244 larva L3 12hr old    157 larva L3 puffstage 1-2    202 larva L3 puffstage 3-6    488 larva L3 puffstage 7-9    535 white prepupae new    600 white prepupae 12hr    936 white prepupae 24hr  1490 pupae 2d postWPP  1533 pupae 3d postWPP    353 pupae 4d postWPP    852 adult male 01day    179 adult male 05day    166 adult male 30day    180 adult female 01day    186 adult female 05day    69 adult female 30day    74 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    47 embryo 02-04hr    59 embryo 04-06hr    63 embryo 06-08hr    489 embryo 08-10hr    1006 embryo 10-12hr    2021 embryo 12-14hr    1924 embryo 14-16hr    2762 embryo 16-18hr    1324 embryo 18-20hr    1114 embryo 20-22hr    618 embryo 22-24hr    516 larva L1    356 larva L2    244 larva L3 12hr old    157 larva L3 puffstage 1-2    202 larva L3 puffstage 3-6    488 larva L3 puffstage 7-9    535 white prepupae new    600 white prepupae 12hr    936 white prepupae 24hr    1490 pupae 2d postWPP    1533 pupae 3d postWPP    353 pupae 4d postWPP    852 adult male 01day    179 adult male 05day    166 adult male 30day    180 adult female 01day    186 adult female 05day    69 adult female 30day    74 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    47 embryo 02-04hr    59 embryo 04-06hr    63 embryo 06-08hr    489 embryo 08-10hr    1006 embryo 10-12hr    2021 embryo 12-14hr    1924 embryo 14-16hr    2762 embryo 16-18hr    1324 embryo 18-20hr    1114 embryo 20-22hr    618 embryo 22-24hr    516 larva L1    356 larva L2    244 larva L3 12hr old    157 larva L3 puffstage 1-2    202 larva L3 puffstage 3-6    488 larva L3 puffstage 7-9    535 white prepupae new    600 white prepupae 12hr    936 white prepupae 24hr    1490 pupae 2d postWPP    1533 pupae 3d postWPP    353 pupae 4d postWPP    852 adult male 01day    179 adult male 05day    166 adult male 30day    180 adult female 01day    186 adult female 05day    69 adult female 30day    74 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0003090    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0003090 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: larval central nervous system. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0003090 expression level Tissue   Expression Level Larval Central Nervous System    199.5 Larval Midgut    7.7 Larval Hindgut    34.3 Larval Malpighian Tubules    4.7 Larval Fat Body    7.1 Larval Salivary Gland    6.5 Larval Trachea    78.275 Larval Carcass    29.675 Adult Head    20.3 Adult Eye    47.4 Adult Brain    17.3 Adult Thoracic-Abdominal Ganglion    16.9 Adult Crop    61.6 Adult Midgut    21.3 Adult Hindgut    42.1 Adult Malpighian Tubules    6 Adult Fat Body no informative data Adult Salivary Gland    7.8 Adult Heart    4.975 Adult VirginFemale Spermatheca    24.1 Adult InseminatedFemale Spermatheca    21.1 Adult Ovary    6 Adult Testis    9.7 Adult Male Accessory Gland no informative data Adult Carcass    32.7 Expression Level Scale  None   Low   Moderate  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    199.5 Larval Midgut    7.7 Larval Hindgut    34.3 Larval Malpighian Tubules    4.7 Larval Fat Body    7.1 Larval Salivary Gland    6.5 Larval Trachea    78.275 Larval Carcass    29.675 Adult Head    20.3 Adult Eye    47.4 Adult Brain    17.3 Adult Thoracic-Abdominal Ganglion    16.9 Adult Crop    61.6 Adult Midgut    21.3 Adult Hindgut    42.1 Adult Malpighian Tubules    6 Adult Fat Body no informative data Adult Salivary Gland    7.8 Adult Heart    4.975 Adult VirginFemale Spermatheca    24.1 Adult InseminatedFemale Spermatheca    21.1 Adult Ovary    6 Adult Testis    9.7 Adult Male Accessory Gland no informative data Adult Carcass    32.7 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    199.5 Larval Midgut    7.7 Larval Hindgut    34.3 Larval Malpighian Tubules    4.7 Larval Fat Body    7.1 Larval Salivary Gland    6.5 Larval Trachea    78.275 Larval Carcass    29.675 Adult Head    20.3 Adult Eye    47.4 Adult Brain    17.3 Adult Thoracic-Abdominal Ganglion    16.9 Adult Crop    61.6 Adult Midgut    21.3 Adult Hindgut    42.1 Adult Malpighian Tubules    6 Adult Fat Body no informative data Adult Salivary Gland    7.8 Adult Heart    4.975 Adult VirginFemale Spermatheca    24.1 Adult InseminatedFemale Spermatheca    21.1 Adult Ovary    6 Adult Testis    9.7 Adult Male Accessory Gland no informative data Adult Carcass    32.7 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    199.5 Larval Midgut    7.7 Larval Hindgut    34.3 Larval Malpighian Tubules    4.7 Larval Fat Body    7.1 Larval Salivary Gland    6.5 Larval Trachea    78.275 Larval Carcass    29.675 Adult Head    20.3 Adult Eye    47.4 Adult Brain    17.3 Adult Thoracic-Abdominal Ganglion    16.9 Adult Crop    61.6 Adult Midgut    21.3 Adult Hindgut    42.1 Adult Malpighian Tubules    6 Adult Fat Body no informative data Adult Salivary Gland    7.8 Adult Heart    4.975 Adult VirginFemale Spermatheca    24.1 Adult InseminatedFemale Spermatheca    21.1 Adult Ovary    6 Adult Testis    9.7 Adult Male Accessory Gland no informative data Adult Carcass    32.7 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0003090 expression level Tissue   Expression Level Larval Central Nervous System    199.5 Larval Midgut    7.7 Larval Hindgut    34.3 Larval Malpighian Tubules    4.7 Larval Fat Body    7.1 Larval Salivary Gland    6.5 Larval Trachea    78.275 Larval Carcass    29.675 Adult Head    20.3 Adult Eye    47.4 Adult Brain    17.3 Adult Thoracic-Abdominal Ganglion    16.9 Adult Crop    61.6 Adult Midgut    21.3 Adult Hindgut    42.1 Adult Malpighian Tubules    6 Adult Fat Body no informative data Adult Salivary Gland    7.8 Adult Heart    4.975 Adult VirginFemale Spermatheca    24.1 Adult InseminatedFemale Spermatheca    21.1 Adult Ovary    6 Adult Testis    9.7 Adult Male Accessory Gland no informative data Adult Carcass    32.7 Expression Level Scale  None   Low   Moderate  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    199.5 Larval Midgut    7.7 Larval Hindgut    34.3 Larval Malpighian Tubules    4.7 Larval Fat Body    7.1 Larval Salivary Gland    6.5 Larval Trachea    78.275 Larval Carcass    29.675 Adult Head    20.3 Adult Eye    47.4 Adult Brain    17.3 Adult Thoracic-Abdominal Ganglion    16.9 Adult Crop    61.6 Adult Midgut    21.3 Adult Hindgut    42.1 Adult Malpighian Tubules    6 Adult Fat Body no informative data Adult Salivary Gland    7.8 Adult Heart    4.975 Adult VirginFemale Spermatheca    24.1 Adult InseminatedFemale Spermatheca    21.1 Adult Ovary    6 Adult Testis    9.7 Adult Male Accessory Gland no informative data Adult Carcass    32.7 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    199.5 Larval Midgut    7.7 Larval Hindgut    34.3 Larval Malpighian Tubules    4.7 Larval Fat Body    7.1 Larval Salivary Gland    6.5 Larval Trachea    78.275 Larval Carcass    29.675 Adult Head    20.3 Adult Eye    47.4 Adult Brain    17.3 Adult Thoracic-Abdominal Ganglion    16.9 Adult Crop    61.6 Adult Midgut    21.3 Adult Hindgut    42.1 Adult Malpighian Tubules    6 Adult Fat Body no informative data Adult Salivary Gland    7.8 Adult Heart    4.975 Adult VirginFemale Spermatheca    24.1 Adult InseminatedFemale Spermatheca    21.1 Adult Ovary    6 Adult Testis    9.7 Adult Male Accessory Gland no informative data Adult Carcass    32.7 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    199.5 Larval Midgut    7.7 Larval Hindgut    34.3 Larval Malpighian Tubules    4.7 Larval Fat Body    7.1 Larval Salivary Gland    6.5 Larval Trachea    78.275 Larval Carcass    29.675 Adult Head    20.3 Adult Eye    47.4 Adult Brain    17.3 Adult Thoracic-Abdominal Ganglion    16.9 Adult Crop    61.6 Adult Midgut    21.3 Adult Hindgut    42.1 Adult Malpighian Tubules    6 Adult Fat Body no informative data Adult Salivary Gland    7.8 Adult Heart    4.975 Adult VirginFemale Spermatheca    24.1 Adult InseminatedFemale Spermatheca    21.1 Adult Ovary    6 Adult Testis    9.7 Adult Male Accessory Gland no informative data Adult Carcass    32.7 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body no informative data Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland no informative data Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    20.3   NA  Eye    47.4   NA  Brain    17.3   199.5  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    16.9   NA  Crop    61.6   7.7  Midgut    21.3   34.3  Hindgut    42.1   4.7  Malpighian Tubules    6   7.1  Fat Body    no informative data   6.5  Salivary Gland    7.8   NA  Heart    4.975   78.275  Trachea    NA   NA  VirginFemale Spermatheca    24.1   NA  InseminatedFemale Spermatheca    21.1   NA  Ovary    6   NA  Testis    9.7   NA  Male Accessory Gland    no informative data   29.675  Carcass    32.7 modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_11
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0003090 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG11084-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele viable pk87 pkf04137 pkf07080 pkGO12 viable, with Scer\GAL4pnr-MD237 pkGD1510 Sterility Allele fertile pkf04137 pkf07080 Other Phenotypes Allele cell polarity defective pkpk.sev pkpk-sple-13 cell polarity defective, with Scer\GAL4hs.2sev pksple.Scer\UAS cell polarity defective, with Scer\GAL4ptc-559.1 pkScer\UAS.cGa pksple.Scer\UAS cell polarity defective | cell non-autonomous, with Scer\GAL4Ubx.PdC pkScer\UAS.cGa planar polarity defective pk1 pk2 pk3 pk5 pk15 pk16 pk17 pk19 pk20 pk21 pk29 pk30 pk44 pkD pkeq pknap2 pkpk-sple-6 pkpk-sple-7 pkpk-sple-8 pkpk-sple-9 pkpk-sple-10 pkpk-sple-11 pkpk-sple-12 pkpk-sple-13 pkpk-sple-14 pkpk-sple-18 pkpk-sple-22 pkpk-sple-23 pkpk-sple-25 pkpk-sple-26 pkpk-sple-32 pkpk-sple-33 pkpk-sple-34 pkpk-sple-35 pkpk-sple-37 pkpk-sple-38 pkpk-sple-39 pkpk-sple-40 pkpk-sple-41 pkpk-sple-43 pkpk-sple-46 pkpk-sple-47 pkpk-sple-48 pkpk-sple-49 pksple-1 pksple-3 pksple-4 pksple-5 pksple-27 pksple-36 pksple-42 pkSZ4 pkunspecified planar polarity defective, with Scer\GAL4Act5C.PI pksple.Scer\UAS planar polarity defective, with Scer\GAL4Act.PU pksple.Scer\UAS planar polarity defective, with Scer\GAL4C-765 pkScer\UAS.cGa planar polarity defective, with Scer\GAL4da.G32 pkEP2557 pkScer\UAS.cGa pksple.Scer\UAS planar polarity defective, with Scer\GAL4pnr-MD237 pkGD1510 planar polarity defective, with Scer\GAL4ptc-559.1 pkScer\UAS.cGa planar polarity defective, with Scer\GAL4αTub84B.PL pksple.Scer\UAS planar polarity defective | cell autonomous, with Scer\GAL4ptc-559.1 pkScer\UAS.cGa planar polarity defective | cell autonomous | somatic clone pk1 pkpk-sple-13 planar polarity defective | cell non-autonomous pk1 planar polarity defective | cell non-autonomous | somatic clone pk1 planar polarity defective | cell non-autonomous | somatic clone, with Scer\GAL4αTub84B.PL pksple.Scer\UAS planar polarity defective | dominant pkTBJ21 planar polarity defective | recessive pk1 pk29 pk30 pk78a pk78d pk78m pkGO12 planar polarity defective | recessive, with Scer\GAL4[-]: pkEP2557 planar polarity defective | somatic clone pkpk-sple-13 planar polarity defective | somatic clone, with Scer\GAL4αTub84B.PL pksple.Scer\UAS planar polarity defective | somatic clone (with pkpk-sple-13) pksple-1 planar polarity defective | somatic clone (with pksple-1) pkpk-sple-13 visible pkD pkpk-sple-13 pksple-1 visible, with Scer\GAL4Act.PU pksple.Scer\UAS visible, with Scer\GAL4dpp.blk1 pkScer\UAS.cGa visible | cold sensitive pksple-3 visible | dominant pkD1 visible | recessive pk1 pk2 pk3 pk5 pk15 pk16 pk17 pk19 pk20 pk21 pk30 pk44 pkGO12 pkpk-sple-6 pkpk-sple-7 pkpk-sple-8 pkpk-sple-9 pkpk-sple-10 pkpk-sple-11 pkpk-sple-12 pkpk-sple-13 pkpk-sple-14 pkpk-sple-18 pkpk-sple-23 pkpk-sple-25 pkpk-sple-26 pkpk-sple-32 pkpk-sple-33 pkpk-sple-34 pkpk-sple-35 pkpk-sple-37 pkpk-sple-38 pkpk-sple-39 pkpk-sple-40 pkpk-sple-41 pkpk-sple-43 pkpk-sple-46 pkpk-sple-47 pkpk-sple-48 pksple-1 pksple-3 pksple-4 pksple-5 pksple-27 pksple-36 pksple-42 pkunspecified visible | recessive, with Scer\GAL4[-]: pkEP2557 visual behavior defective pkpk-sple-6 pkpk-sple-7 pkpk-sple-8 pkpk-sple-9 pkpk-sple-10 pkpk-sple-14 pkpk-sple-18 pkpk-sple-25 Phenotype manifest in Allele abdomen pkpk-sple-10 pkpk-sple-11 pkpk-sple-12 pkpk-sple-13 pkpk-sple-14 pkpk-sple-18 pkpk-sple-22 pkpk-sple-23 pkpk-sple-25 pkpk-sple-26 pkpk-sple-32 pkpk-sple-33 pkpk-sple-34 pkpk-sple-35 pkpk-sple-37 pkpk-sple-38 pkpk-sple-39 pkpk-sple-40 pkpk-sple-41 pkpk-sple-43 pkpk-sple-46 pkpk-sple-47 pkpk-sple-48 pkpk-sple-49 pkpk-sple-6 pkpk-sple-7 pkpk-sple-8 pkpk-sple-9 pksple-1 pksple-27 pksple-3 pksple-36 pksple-4 pksple-42 pksple-5 abdomen & macrochaeta pksple-1 abdominal sternite & macrochaeta pksple-1 abdominal tergite & macrochaeta pksple-1 dorsal wing blade pkpk-sple-14 dorsal wing blade, with Scer\GAL4Bx-MS1096 pkScer\UAS.cGa dorsal wing blade | anterior pk30 dorsal wing blade | posterior (with pksple-1) pksple-27 dorsal wing blade | posterior (with pksple-27) pksple-1 eye pkpk-sple-10 pkpk-sple-11 pkpk-sple-12 pkpk-sple-13 pkpk-sple-14 pkpk-sple-18 pkpk-sple-22 pkpk-sple-23 pkpk-sple-25 pkpk-sple-26 pkpk-sple-32 pkpk-sple-33 pkpk-sple-34 pkpk-sple-35 pkpk-sple-37 pkpk-sple-38 pkpk-sple-39 pkpk-sple-40 pkpk-sple-41 pkpk-sple-43 pkpk-sple-46 pkpk-sple-47 pkpk-sple-48 pkpk-sple-49 pkpk-sple-6 pkpk-sple-7 pkpk-sple-8 pkpk-sple-9 pksple-1 pksple-27 pksple-3 pksple-36 pksple-4 pksple-42 pksple-5 eye photoreceptor cell | somatic clone pkpk-sple-13 eye photoreceptor cell | somatic clone (with pkpk-sple-13) pksple-1 eye photoreceptor cell | somatic clone (with pksple-1) pkpk-sple-13 joint | ectopic pksple-1 leg pkeq pkpk-sple-10 pkpk-sple-11 pkpk-sple-12 pkpk-sple-13 pkpk-sple-14 pkpk-sple-18 pkpk-sple-22 pkpk-sple-23 pkpk-sple-25 pkpk-sple-26 pkpk-sple-32 pkpk-sple-33 pkpk-sple-34 pkpk-sple-35 pkpk-sple-37 pkpk-sple-38 pkpk-sple-39 pkpk-sple-40 pkpk-sple-41 pkpk-sple-43 pkpk-sple-46 pkpk-sple-47 pkpk-sple-48 pkpk-sple-49 pkpk-sple-6 pkpk-sple-7 pkpk-sple-8 pkpk-sple-9 pksple-1 pksple-27 pksple-3 pksple-36 pksple-4 pksple-42 pksple-5 leg & macrochaeta pkpk-sple-10 pkpk-sple-14 pkpk-sple-18 pkpk-sple-25 pkpk-sple-6 pkpk-sple-7 pkpk-sple-8 pkpk-sple-9 pksple-1 leg & trichome pkpk-sple-10 pkpk-sple-14 pkpk-sple-18 pkpk-sple-25 pkpk-sple-6 pkpk-sple-7 pkpk-sple-8 pkpk-sple-9 pksple-1 mesothoracic tergum & sensory mother cell & spindle pkpk-sple-14 metatarsus pksple-1 metatarsus, with Scer\GAL4C-765 pkScer\UAS.cGa metatarsus, with Scer\GAL4da.G32 pkScer\UAS.cGa ommatidium pkeq pkpk-sple-13 pkpk.sev pksple-1 pksple-27 pksple-3 pksple-36 pksple-4 pksple-42 pksple-5 pkunspecified ommatidium, with Scer\GAL4hs.2sev pksple.Scer\UAS ommatidium | somatic clone pkpk-sple-13 ommatidium | somatic clone (with pkpk-sple-13) pksple-1 ommatidium | somatic clone (with pksple-1) pkpk-sple-13 photoreceptor cell R4 | precursor | somatic clone pkpk-sple-13 pksple-1 scutum pk1 pk15 pk16 pk17 pk19 pk2 pk20 pk21 pk29 pk3 pk30 pk44 pk5 pkSZ4 pkpk-sple-10 pkpk-sple-11 pkpk-sple-12 pkpk-sple-13 pkpk-sple-14 pkpk-sple-18 pkpk-sple-22 pkpk-sple-23 pkpk-sple-25 pkpk-sple-26 pkpk-sple-32 pkpk-sple-33 pkpk-sple-34 pkpk-sple-35 pkpk-sple-37 pkpk-sple-38 pkpk-sple-39 pkpk-sple-40 pkpk-sple-41 pkpk-sple-43 pkpk-sple-46 pkpk-sple-47 pkpk-sple-48 pkpk-sple-49 pkpk-sple-6 pkpk-sple-7 pkpk-sple-8 pkpk-sple-9 scutum, with Scer\GAL4[-]: pkEP2557 tarsal segment 1 & joint pksple-1 tarsal segment 1 & joint, with Scer\GAL4C-765 pkScer\UAS.cGa tarsal segment 1 & joint, with Scer\GAL4da.G32 pkScer\UAS.cGa tarsal segment 2 pksple-1 tarsal segment 2, with Scer\GAL4C-765 pkScer\UAS.cGa tarsal segment 3 pkpk-sple-13 pksple-1 pksple-3 tarsal segment 3, with Scer\GAL4C-765 pkScer\UAS.cGa tarsal segment 3 & joint pkpk-sple-13 pksple-3 tarsal segment 4 pkpk-sple-13 pksple-1 pksple-3 tarsal segment 4, with Scer\GAL4C-765 pkScer\UAS.cGa tarsal segment 4 & joint pkpk-sple-13 pksple-3 tarsal segment, with Scer\GAL4[-]: pkEP2557 tarsal segment, with Scer\GAL4C-765 pkScer\UAS.cGa tarsal segment, with Scer\GAL4da.G32 pkScer\UAS.cGa tarsal segment & joint pksple-1 thorax pkeq trichome pksple-1 trichome & adult abdomen pkGO12 trichome & adult abdomen | posterior compartment, with Scer\GAL4αTub84B.PL pksple.Scer\UAS trichome & adult abdomen | somatic clone | cell autonomous pk1 pkpk-sple-13 trichome & adult abdomen | somatic clone | posterior compartment, with Scer\GAL4αTub84B.PL pksple.Scer\UAS trichome & costal cell pkunspecified triple row pk1 pkpk-sple-13 triple row, with Scer\GAL4C-765 pksple.Scer\UAS triple row, with Scer\GAL4da.G32 pkEP2557 pksple.Scer\UAS wing pk1 pk15 pk16 pk17 pk19 pk2 pk20 pk21 pk29 pk3 pk30 pk44 pk5 pkSZ4 pkeq pknap2 pkpk-sple-10 pkpk-sple-11 pkpk-sple-12 pkpk-sple-13 pkpk-sple-14 pkpk-sple-18 pkpk-sple-22 pkpk-sple-23 pkpk-sple-25 pkpk-sple-26 pkpk-sple-32 pkpk-sple-33 pkpk-sple-34 pkpk-sple-35 pkpk-sple-37 pkpk-sple-38 pkpk-sple-39 pkpk-sple-40 pkpk-sple-41 pkpk-sple-43 pkpk-sple-46 pkpk-sple-47 pkpk-sple-48 pkpk-sple-49 pkpk-sple-6 pkpk-sple-7 pkpk-sple-8 pkpk-sple-9 wing, with Scer\GAL4C-765 pksple.Scer\UAS wing, with Scer\GAL4da.G32 pkEP2557 pksple.Scer\UAS wing & cell pk30 wing & pupa & cell, with Scer\GAL4en-e16E pkScer\UAS.cGa wing | cell autonomous | somatic clone pk1 pkpk-sple-13 wing | cell non-autonomous | somatic clone pk1 pkpk-sple-13 wing blade, with Scer\GAL4C-765 pksple.Scer\UAS wing blade, with Scer\GAL4hs.PB pksple.Scer\UAS wing cell | P-stage pk1 wing hair pk1 pk29 pk30 pk78a pk78d pk78m pkD pknap2 pkpk-sple-10 pkpk-sple-13 pkpk-sple-14 pkpk-sple-18 pkpk-sple-25 pkpk-sple-6 pkpk-sple-7 pkpk-sple-8 pkpk-sple-9 wing hair, with Scer\GAL4Act5C.PI pksple.Scer\UAS wing hair, with Scer\GAL4Act.PU pksple.Scer\UAS wing hair, with Scer\GAL4Bx-MS1096 pkScer\UAS.cGa wing hair, with Scer\GAL4C-765 pkScer\UAS.cGa pksple.Scer\UAS wing hair, with Scer\GAL4da.G32 pkEP2557 pkScer\UAS.cGa pksple.Scer\UAS wing hair, with Scer\GAL4dpp.blk1 pkScer\UAS.cGa wing hair, with Scer\GAL4hs.PB pksple.Scer\UAS wing hair, with Scer\GAL4ptc-559.1 pkScer\UAS.cGa pksple.Scer\UAS wing hair, with Scer\GAL4Ubx.PdC pkScer\UAS.cGa wing hair & 1st posterior cell, with Scer\GAL4ptc-559.1 pkScer\UAS.cGa wing hair & cell & pupa, with Scer\GAL4en-e16E pkScer\UAS.cGa wing hair | somatic clone pk1
Classical Alleles ( 91 )
For All Classical Alleles Show
Allele of pk Class Mutagen Stocks Known lesion pk1 loss of function allele, hypomorphic allele - genetic evidence spontaneous 20 Yes pkpk-sple-26 X ray 5 Yes pksple-1 amorphic allele - genetic evidence spontaneous 2 -- pkf07080 piggyBac transposase 2 -- pksple-3 ethyl methanesulfonate 2 -- pkc06494a 1 -- pkc06494b 1 -- pkc07118 1 -- pkCB-0807-3 1 -- pkd01362 P-element activity 1 -- pkeq loss of function allele 1 -- pkEY22963 P-element activity 1 -- pkf04137 piggyBac transposase 1 -- pkKG05718 1 -- pkMB11776 1 -- pkMI02868 1 -- pkNP2567 1 -- pkNP7324 1 -- pkpk-sple-22 X ray 1 Yes pkpk-sple-6 ethyl methanesulfonate 1 -- pkSZ4 amorphic allele - genetic evidence spontaneous 0 Yes pk15 PM hybrid dysgenesis P-element activity 0 Yes pk16 P-element activity 0 Yes pk17 P-element activity 0 Yes pk19 X ray 0 Yes pk20 X ray 0 Yes pk21 X ray 0 Yes pk29 X ray 0 Yes pk2 X ray 0 Yes pk30 X ray 0 Yes pk3 ethyl methanesulfonate 0 -- pk44 X ray 0 Yes pk5 X ray ethyl methanesulfonate 0 -- pk78a X ray 0 -- pk78b X ray 0 -- pk78d X ray 0 -- pk78f X ray 0 -- pk78g X ray 0 -- pk78l X ray 0 -- pk78m X ray 0 -- pk87 X ray ethyl methanesulfonate 0 -- pkcn76k3 gamma ray 0 Yes pkcn88e43 gamma ray 0 Yes pkD1-rv1 spontaneous 0 -- pkD1-rv4 spontaneous 0 -- pkD1-rv5 spontaneous 0 -- pkD1-rv6 spontaneous 0 -- pkD1-rv7 spontaneous 0 -- pkD1-rv9 spontaneous 0 -- pkD1 spontaneous 0 -- pkD antimorphic allele - genetic evidence 0 -- pkEP2557 P-element activity 0 Yes pkGO12 0 -- pkJJ13 0 -- pkN4 0 -- pknap2 X ray 0 Yes pkNpk ethyl methanesulfonate 0 -- pkpk-sple-10 X ray 0 -- pkpk-sple-11 X ray 0 -- pkpk-sple-12 X ray 0 -- pkpk-sple-13 X ray 0 Yes pkpk-sple-14 X ray 0 Yes pkpk-sple-18 X ray 0 -- pkpk-sple-23 X ray 0 Yes pkpk-sple-25 ethyl methanesulfonate 0 -- pkpk-sple-28 X ray 0 -- pkpk-sple-32 X ray 0 -- pkpk-sple-33 P-element activity 0 -- pkpk-sple-34 X ray 0 -- pkpk-sple-35 X ray 0 Yes pkpk-sple-37 X ray 0 Yes pkpk-sple-38 X ray 0 -- pkpk-sple-39 X ray 0 -- pkpk-sple-40 X ray 0 Yes pkpk-sple-41 X ray 0 -- pkpk-sple-43 X ray 0 -- pkpk-sple-46 X ray 0 Yes pkpk-sple-47 X ray 0 Yes pkpk-sple-48 X ray 0 Yes pkpk-sple-49 X ray 0 Yes pkpk-sple-7 ethyl methanesulfonate 0 -- pkpk-sple-8 ethyl methanesulfonate 0 -- pkpk-sple-9 ethyl methanesulfonate 0 -- pksple-27 X ray 0 -- pksple-2 X ray 0 -- pksple-36 X ray 0 -- pksple-42 X ray 0 -- pksple-4 X ray 0 -- pksple-5 ethyl methanesulfonate 0 -- pkTBJ21 antimorphic allele - genetic evidence 0 -- pkunspecified 0 --
Alleles Carried on Transgenic Constructs ( 11 )
For All Alleles Carried on Transgenic Constructs Show
Allele of pk Class Mutagen Stocks Known lesion pkGD1510 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes pkHMS00408 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes pkKK109294 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes pkNIG.11084R in vitro construct - regulatory fusion in vitro construct - RNAi 0 Yes pkpk.sev in vitro construct - regulatory fusion 0 Yes pkScer\UAS.cGa in vitro construct - regulatory fusion 0 Yes pksple.CtoA.sev in vitro construct - site directed mutagenesis 0 Yes pksple.Scer\UAS in vitro construct - regulatory fusion 0 Yes pksple.sev in vitro construct - regulatory fusion 0 Yes pksple.ΔC1.sev in vitro construct - deletion 0 -- pksple.ΔC2.sev in vitro construct - deletion 0 --
Aneuploid Aberrations
Disrupted in	Df(2R)cn-S5 (Heitzler et al., 1993) Df(2R)Drlrv3 (Heitzler et al., 1993) Df(2R)Drlrv5 (Heitzler et al., 1993) Df(2R)Drlrv7 (Heitzler et al., 1993) Df(2R)Drlrv15 (Heitzler et al., 1993) Df(2R)Drlrv17 (Heitzler et al., 1993) Df(2R)Drlrv18 (Heitzler et al., 1993) Df(2R)Drlrv20 (Heitzler et al., 1993) Df(2R)Drlrv24 (Heitzler et al., 1993) Df(2R)Drlrv25 (Heitzler et al., 1993) Df(2R)Drlrv26 (Heitzler et al., 1993) Df(2R)Drlrv28 (Heitzler et al., 1993) Df(2R)nap2 (Gubb et al., 1999, Green et al., 2000, Heitzler et al., 1993) Df(2R)Npk-rv1 (Roote and Ashburner, 2005.6) Df(2R)Npk-rv2 (Roote and Ashburner, 2005.6) Df(2R)Npk-rv4 (Roote and Ashburner, 2005.6) Df(2R)Npk-rv5 (Roote and Ashburner, 2005.6) Df(2R)pk78k (Ashburner et al., 1981) Df(2R)pk78r (Ashburner et al., 1981) Df(2R)pk78s (Ashburner et al., 1981) Df(2R)pk30 (Gubb et al., 1999, Green et al., 2000) Df(2R)pk-N5 (Gubb et al., 1999, Heitzler et al., 1993) Df(2R)pk-sple-50 (Gubb et al., 1999) Df(2R)pk-sple-51 (Gubb et al., 1999) Df(2R)sple-78b (Gubb and Garcia-Bellido, 1982) Df(2R)sple-D1 (Heitzler et al., 1993) Df(2R)sple-D2 (Green et al., 2000, Heitzler et al., 1993) Df(2R)sple-D3 (Heitzler et al., 1993) Df(2R)sple-J1 (Heitzler et al., 1993) Df(2R)sple-J2 (Gubb et al., 1999, Heitzler et al., 1993) Df(2R)sple-N3 (Heitzler et al., 1993) Df(2R)ST1 (Ashburner et al., 1981) In(2LR)pk-20 (Gubb et al., 1999) In(2LR)pk-21 (Gubb et al., 1999) In(2LR)pk44 (Gubb et al., 1999) In(2LR)pkD1-rv1 (Roote, 1997.6.6) In(2LR)pkD1-rv4 (Roote, 1997.6.6) In(2LR)pkD1-rv5 (Roote, 1997.6.6) In(2LR)pkD1-rv6 (Roote, 1997.6.6) In(2LR)pkD1-rv7 (Roote, 1997.6.6) In(2LR)pkD1-rv9 (Roote, 1997.6.6) In(2LR)pkD1-rv2 (Roote, 1997.6.6) In(2LR)pkD1-rv3 (Roote, 1997.6.6) In(2LR)pkD1-rv8 (Roote, 1997.6.6) In(2LR)pkD1-rv10 (Roote, 1997.6.6) In(2LR)pkD1-rv11 (Roote, 1997.6.6) In(2LR)pkD1-rv12 (Roote, 1997.6.6) In(2LR)pk-sple47 (Gubb et al., 1999) In(2LR)TE35B-4 (Gubb et al., 1999, Gubb et al., 1986) In(2LR)TE35B-4LTE35B-250R (Roote, 1997.6.6) In(2LR)TE35B-14LTE35B-4R (Roote, 1996.8, Roote, 1997.6.6) In(2LR)TE35B-14LTE35B-250R (Roote, 1997.6.6) In(2R)CanB287 (Sullivan and Rubin, 2002) In(2R)nec-5 (Gubb et al., 1999, Roote, 1995.9.26) In(2R)nec-e3 (Gubb et al., 1999, Roote, 1995.9.26) In(2R)pk-19 (Gubb et al., 1999) In(2R)pk-sple40 (Gubb et al., 1999) T(2;3)pk29 (Gubb, 1998.2.25, Gubb et al., 1999) T(2;3)pk-sple31 (Gubb et al., 1999) T(2;3)pk-sple37 (Gubb et al., 1999) T(Y;2)pk-sple45 (Gubb et al., 1999) Tp(2;2)pk-sple22 (Gubb et al., 1999, Heitzler et al., 1993) Tp(2;2)pk-sple24 (Gubb et al., 1999) Tp(2;2)pk-sple26 (Gubb et al., 1999, Roote, 1996.3.6) Tp(2;2)pk-sple49 (Gubb et al., 1999)
Not disrupted in	Df(2L)C (Hilliker and Holm, 1975, Cicchetti and Loverre, 1989) Df(2L)C' (Cicchetti and Loverre, 1989) Df(2L)D (Hilliker and Holm, 1975, Cicchetti and Loverre, 1989) Df(2L)D' (Hilliker and Holm, 1975, Cicchetti and Loverre, 1989) Df(2L)TW65 (Cicchetti and Loverre, 1989) Df(2L)TW161 (Cicchetti and Loverre, 1989) Df(2R)B (Hilliker and Holm, 1975) Df(2R)cn-S3 (Heitzler et al., 1993) Df(2R)cn-S6 (Heitzler et al., 1993) Df(2R)cn-S8 (Heitzler et al., 1993) Df(2R)cos-2 (Heitzler et al., 1993) Df(2R)cos-3 (Heitzler et al., 1993) Df(2R)Drlrv21 (Heitzler et al., 1993) Df(2R)Drlrv22 (Heitzler et al., 1993) Df(2R)Drlrv30 (Heitzler et al., 1993) Df(2R)DX1 (Heitzler et al., 1993) Df(2R)DX14 (Heitzler et al., 1993) Df(2R)EW60 (Heitzler et al., 1993) Df(2R)H23 (Heitzler et al., 1993) Df(2R)M41A4 (Cicchetti and Loverre, 1989) Df(2R)M41A8 (Cicchetti and Loverre, 1989) Df(2R)M41A10 (Cicchetti and Loverre, 1989) Df(2R)NCX5 (Heitzler et al., 1993) Df(2R)NCX8 (Heitzler et al., 1993) Df(2R)NCX9 (Heitzler et al., 1993) Df(2R)NCX10 (Heitzler et al., 1993) Df(2R)NCX11 (Heitzler et al., 1993) Df(2R)NCX13 (Heitzler et al., 1993) Df(2R)Npk-rv3 (Roote and Ashburner, 2005.6) Df(2R)pwn5 (Heitzler et al., 1993) Df(2R)rl-D (Hilliker and Holm, 1975, Cicchetti and Loverre, 1989) Df(2R)tor-rx6 (Heitzler et al., 1993) In(2LR)TE35B-14 (Gubb et al., 1986) T(2;3)EHH (Hilliker and Holm, 1975) Tp(1;2)TE35B-SR36 (Gubb et al., 1986)
Partially disrupted in	Df(2R)Npk-rv6 (Roote and Ashburner, 2005.6) Df(2R)Npk-rv7 (Roote and Ashburner, 2005.6)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD1510} NA P{KK109294} NA P{TRiP.HMS00408} NA P{UAS-pk.G} NA P{UAS-sple+} NA characterization construct P{NIG.11084R} NA P{sev-pkpk} NA P{sev-pksple.CtoA} NA P{sev-pksple.ΔC1} NA P{sev-pksple.ΔC2} NA P{sev-pksple} NA
Insertions
	Type of insertions Name Expression data miscellaneous insertions Mi{MIC}Spn43AbMI02868 NA P{}pk15 NA P{}pk16 NA P{}pk17 NA P{}pkpk-sple-33 NA P{RS3}pkCB-0807-3 NA P{SUPor-P}pkKG05718 NA P{unk}pkGO12 NA PBac{PB}pkc06494a NA PBac{PB}pkc06494b NA PBac{PB}pkc07118 NA PBac{WH}pkf04137 NA PBac{WH}pkf07080 NA insertion of enhancer trap P{lacW}l(2)SH0214SH0214 No insertion of enhancer trap binary system Mi{ET1}pkMB11776 No P{GawB}pkNP2567 No P{GawB}pkNP7324 No insertion of mobile activating element P{EP}pkEP2557 NA P{EPgy2}pkEY22963 NA P{XP}pkd01362 NA
Gene Ontology: Function, Process & Cellular Component ( 11 unique terms )
Terms Based on Experimental Evidence ( 4 terms )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
establishment of imaginal disc-derived wing hair orientation inferred from mutant phenotype (Hogan et al., 2011) establishment of ommatidial planar polarity inferred from mutant phenotype (Zheng et al., 1995) establishment or maintenance of cell polarity inferred from mutant phenotype (Tree et al., 2002) morphogenesis of a polarized epithelium inferred from mutant phenotype (Classen et al., 2005)
Cellular Component ( 0 terms)
Terms Based on Predictions or Assertions ( 9 terms )
Molecular Function
CV term Evidence References
zinc ion binding inferred from electronic annotation with InterPro:IPR001781, InterPro:IPR010442 (FlyBase Curators et al., 2004-)
Biological Process
CV term Evidence References
establishment of imaginal disc-derived wing hair orientation traceable author statement (Tree et al., 2002) establishment of planar polarity traceable author statement (Torban et al., 2004, Mlodzik, 2002) establishment of protein localization traceable author statement (Mlodzik, 2002) establishment or maintenance of cell polarity non-traceable author statement (Gubb, 1999.7.5) maintenance of protein location traceable author statement (Mlodzik, 2002) protein localization traceable author statement (Cadigan, 2002)
Cellular Component
CV term Evidence References
cytoplasm traceable author statement (Mlodzik, 2002) membrane non-traceable author statement (Mlodzik, 2002)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions pk allele Gene References pk1 fz (Adler et al., 2000) in (Lee and Adler, 2002) Vang (Taylor et al., 1998, Rawls and Wolff, 2003) pk30 dsh (Gubb et al., 1999) pkD fz (Adler et al., 2000) Vang (Adler et al., 2000) pkJJ13 Vang (Taylor et al., 1998) pkpk.sev dsh (Jenny et al., 2003) fz (Jenny et al., 2003) Vang (Jenny et al., 2003) pkpk-sple-9 Rac1 (Fanto et al., 2000) pkpk-sple-13 dsh (Tree et al., 2002) N (Cooper and Bray, 1999) Vang (Jenny et al., 2003) pkpk-sple-26 Vang (Jenny et al., 2003) pkScer\UAS.cGa in (Lee and Adler, 2002) pksple-1 dsh (Gubb et al., 1999) pksple.Scer\UAS dgo (Jenny et al., 2003) dsh (Jenny et al., 2003) fy (Lee and Adler, 2002) fz (Jenny et al., 2003) in (Lee and Adler, 2002) stan (Jenny et al., 2003) Vang (Jenny et al., 2003) pkTBJ21 Vang (Taylor et al., 1998) unspecified dco (Strutt et al., 2006) dgo (Jenny et al., 2005) sha (Ren et al., 2006)
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 69608 DroID - A comprehensive database of gene and protein interactions. • FBgn0003090 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 45343
Orthologs
Genome-wide drosophilid orthologs	Dana\GF12702 Dere\GG23268 Dgri\GH21524 Dmoj\GI19495 Dper\GL11157 Dpse\GA10748 Dsec\GM20940 Dsim\GD10467 Dvir\GJ15157 Dwil\GK21795 Dyak\GE19116
Curated drosophilid orthologs	Dpse\GA10748 (Burnette, 2005)
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL006891-PA Aedes aegypti (mosquito) XP_394201.2 Apis mellifera (honey bee) BGIBMGA012622-PA Bombyx mori (silk worm) ENSBTAP00000011340 Bos taurus (bovine) ENSCAFP00000010158 Canis familiaris (dog) ENSCAFP00000023232 Canis familiaris (dog) CPIJ012800 Culex pipens (mosquito) ENSCPOP00000001189 Cavia porcellus (guinea pig) ENSCSAVP00000010650 Ciona savignyi (sedentary tunicate) DDB0191181 Dictyostelium discoideum (amoeba) ENSDARP00000054743 Danio rerio (zebra fish) ENSDARP00000067176 Danio rerio (zebra fish) ENSGACP00000012277 Gymnopilus aculeatus (mushroom) ISCW000275-PA Ixodes scapularis (deer tick) ENSMODP00000003767 Monodelphis domestica (gray opossum) ENSMUSP00000032093 Mus musculus (house mouse) XP_001599422.1 Nasonia vitripennis (wasp) ENSOANP00000018910 Ornithorynchus anatinus (platypus) PHUM007048-PA Pediculus humanus (human body louse) ENSRNOP00000016628 Rattus norvegicus (norway rat) ENSTNIP00000014072 Tetraodon nigroviridis (green spotted pufferfish) ENSTNIP00000019074 Tetraodon nigroviridis (green spotted pufferfish) 81997.m00130 Trichomonas vaginalis (parasitic flagellated protozoan) 85262.m00064 Trichomonas vaginalis (parasitic flagellated protozoan) 95305.m00222 Trichomonas vaginalis (parasitic flagellated protozoan) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • NV17517 LH21095 ISCW000275 FBgn0236476 FBgn0236468 FBgn0223780 FBgn0223775 FBgn0202354 FBgn0202343 FBgn0182229 FBgn0175821 FBgn0175813 JGI_V11_21094 FBgn0071889 FBgn0070804 FBgn0148767 FBgn0148763 FBgn0142233 FBgn0142223 FBgn0028642 FBgn0128986 FBgn0128978 FBgn0115419 FBgn0115409 FBgn0089730 CPIJ012800 BGIBMGA012622 ACYPI001229 GB18513 PRIC1_ANOGA PRIC1_AEDAE PB25866 PB25868 PHUM142030 GLEAN_09830
Stocks & Reagents
Stocks Listed in FlyBase ( 47 )
Bloomington	422 pksple-1 367 pk1 cn1 19038 w1118; PBac{WH}pkf07080
Harvard	- P{XP}pkd01362 - PBac{PB}pkc07118 - PBac{WH}pkf04137 - PBac{WH}pkf07080
Kyoto	105903 pksple-1 105875 pk1 cn1 101551 pkpk-sple-6 bwD / SM5
VDRC	v101480 P{KK109294}VIE-260B v11099 w1118; P{GD1510}v11099
	More stocks available...
Genomic Clones ( 1 )
	BACR12F04 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 124 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones
Other clones	MIP29539 MIP30039 MIP30239
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	AT16013 AT25571 GH17272 RE45055 RE53763 RE55048 RE61907 RH07230 RH07396 RH08307 RH08317 RH08558 RH13688 RH34593 RH46385 RH47379 RH51038 RH63725 SD05284 SD06788 SD07240 SD11428 SD14952 SD16092 SD19808 SD19832 SD20610 SD22651 SD26391
Other clones	28578 98359 146298 214219.32 214371.8 214479.42 281511 CK01.143A.D10 CK01449 CK01771 CK02256 CK02355 CK02684 CK02693 EC054349 EK026156 EK038332 EK053803 EK057316 EK059327 EK060011 EK062229 EK062839 EK084963 EK090809 EK092643 EK093145 EK097007 EK100937 EK102527 EK105244 EK106046 EK106728 EK109250 EK110833 EK116245 EK119043 EK135752 EK143704 EK146664 EK155537 EK156329 EK157360 EK157701 EK159162 EK159163 EK166349 EK167802 EK176904 EK179526 EK186020 EK197806 EK197836 EK200229 EK207953 EK209943 EK213836 EK220109 EK221341 EK230464 EK234764 EK241457 EK245728 EK245947 EK249140 EK262215 EK264004 EK284052 EK290234 EK291606 EK293141 EK298525 EK301608 EK302908 EK307140 EN12324 EP00644 EP00647 EP02139 EP05631 EP10112 EP11538 EP11627 EP12425 EP13216 EP13712 EP15463 EP19647 EP22363 IP02267 IP03216 SD05264
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0003090 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 45343
Antibody Information
Other Information
Discoverer
	Ives, Nov. 1938.
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of	Source for merge of: pk CG11084 (Bayraktaroglu, 2000.4.13) Source for merge of: pk CG12830 (FlyBase Genome Annotators, 2002-2003)
Additional comments	Annotations CG12830 and CG11084 merged as CG11084 (which corresponds to pk) in release 3 of the genome annotation. (FlyBase Genome Annotators, 2002-2003)
Other Comments
	During development of the bristle lineage, Vang protein is localised in an anterior crescent in dividing sensillum precursor cells. (Bellaiche et al., 2004) Mutations in fz-like class of genes fz, pk, Vang, stan and dsh act as strong enhancers of weak in or fy phenotypes. (Lee and Adler, 2002) in and fy are needed for cells to respond to pk and stan. Genetic analysis is not consistent with fz-like class of genes fz, pk, Vang, stan and dsh acting simply as positive or negative regulators of in and fy. (Lee and Adler, 2002) pk is required for a feedback loop that generates asymmetric planar cell polarity signalling in the wing. (Tree et al., 2002) The "Pk" class of alleles carry molecular lesions within the proximal 30kb of the transcription unit, whereas the "Pk-Sple" class of alleles map to the distal section of the transcription unit. In direction of increasing cytology: Spn43Aa+ pk+ Spn43Ab- nec- pk+ Ady43A- (Gubb et al., 1999) Alleles can be divided into three phenotypic classes, "Pk", "Pk-Sple", and "Sple". No allele causes an embryonic phenotype, even when homozygous mutant embryos develop from homozygous mutant mothers. Deletions of the pk gene are fully viable and fertile. The defects of the double mutant "Pk-Sple" class are the same as those seen with deletions of the entire gene. Paradoxically the "Pk" and "Sple" classes give more severe phenotypes with "Pk" affecting the wing and notum and "Sple" in the legs abdomen and eyes. (Gubb et al., 1999) The balance between the pk isoforms "Pk" and "Sple" is critical for the specification of planar polarity. (Gubb et al., 1999) pk is a slightly haploinsufficient gene. A deficiency for pk (and some pk point mutants) shows a weak, partially penetrant dominant tissue polarity phenotype. This effect is enhanced by several Vang alleles. Phenotypic data suggest that genetics of Vang and its interactions with pk are complex. Several, but not all, Vang alleles act as enhancers of the pk haploinsufficient tissue polarity phenotype, and the pkTBJ21 antimorphic phenotype. Mutations in pk can also act as suppressors of Vang dominant phenotypes. (Taylor et al., 1998) Mutants do not exhibit defects in the denticle belt of hairs of the larvae. (Dickinson and Thatcher, 1997) In pk mutants the dorsal/ventral boundary in the eye is respected but the mechanism for ommatidial polarization is perturbed. A likely explanation for the observed phenotype is that the fates of dorsal and ventral cells within a cluster have been interchanged. (Choi et al., 1996) Mosaic analysis demonstrates pk function in either R3, R4 or R5 photoreceptor cell appears to be sufficient to drive an ommatidium in the right direction. (Zheng et al., 1995) Polarity pattern of wing, haltere and notum altered. Triple row bristles on anterior wing slanted proximally instead of distally. On the notum, the posterior acrostichal bristles are whorled. (Lindsley and Zimm, 1992) Trichomes near L2 vein arranged in counterclockwise whorl on right wing blade, in clockwise whorl on left blade; trichomes in anterior wing occasionally duplicated. Somatic clones of homozygous pk mutant cells have been generated. Not a vital locus. (Gubb and Garcia-Bellido, 1982) "AQ254872; BDGP:EP(2)2557" was stated as revision.
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_165508 NM_165509 NM_165512 RefSeq (Proteins) • NP_724534 NP_724535 NP_724538 DDBJ / EMBL / GenBank • AAF59281 AAF59284 AAM68908 AAY82222 AAY82223 AJ243708 AJ243709 AJ243710 AQ254872 CAB57344 CAB57345 CAB99211 CZ472184 CZ486664 CZ486665 CZ489851 DQ017440 DQ017441 Entrez Gene - A searchable database of RefSeq genes. • 45343 UniProtKB/TrEMBL • A1Z6W3 Q3YNB2
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Zinc finger, LIM-type (IPR001781) PET domain (IPR010442)
Linkouts
	BioGRID - A database of protein and genetic interactions • 69608 DroID - A comprehensive database of gene and protein interactions. • FBgn0003090 DRSC - Results from RNAi screens. • FBgn0003090 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0003090 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG11084-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0003090 FlyReactome - A curated knowledgebase of Drosophila melanogaster pathways • 243896 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 45343 InParanoid A subset of ortholog calls from InParanoid. • AAEL006891-PA Aedes aegypti (mosquito) XP_394201.2 Apis mellifera (honey bee) BGIBMGA012622-PA Bombyx mori (silk worm) ENSBTAP00000011340 Bos taurus (bovine) ENSCAFP00000010158 Canis familiaris (dog) ENSCAFP00000023232 Canis familiaris (dog) CPIJ012800 Culex pipens (mosquito) ENSCPOP00000001189 Cavia porcellus (guinea pig) ENSCSAVP00000010650 Ciona savignyi (sedentary tunicate) DDB0191181 Dictyostelium discoideum (amoeba) ENSDARP00000054743 Danio rerio (zebra fish) ENSDARP00000067176 Danio rerio (zebra fish) ENSGACP00000012277 Gymnopilus aculeatus (mushroom) ISCW000275-PA Ixodes scapularis (deer tick) ENSMODP00000003767 Monodelphis domestica (gray opossum) ENSMUSP00000032093 Mus musculus (house mouse) XP_001599422.1 Nasonia vitripennis (wasp) ENSOANP00000018910 Ornithorynchus anatinus (platypus) PHUM007048-PA Pediculus humanus (human body louse) ENSRNOP00000016628 Rattus norvegicus (norway rat) ENSTNIP00000014072 Tetraodon nigroviridis (green spotted pufferfish) ENSTNIP00000019074 Tetraodon nigroviridis (green spotted pufferfish) 81997.m00130 Trichomonas vaginalis (parasitic flagellated protozoan) 85262.m00064 Trichomonas vaginalis (parasitic flagellated protozoan) 95305.m00222 Trichomonas vaginalis (parasitic flagellated protozoan) Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution • /dbzhnsky/prickl1.htm InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 45343 modMine - Data generated by the modENCODE project. • FBgn0003090 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • NV17517 LH21095 ISCW000275 FBgn0236476 FBgn0236468 FBgn0223780 FBgn0223775 FBgn0202354 FBgn0202343 FBgn0182229 FBgn0175821 FBgn0175813 JGI_V11_21094 FBgn0071889 FBgn0070804 FBgn0148767 FBgn0148763 FBgn0142233 FBgn0142223 FBgn0028642 FBgn0128986 FBgn0128978 FBgn0115419 FBgn0115409 FBgn0089730 CPIJ012800 BGIBMGA012622 ACYPI001229 GB18513 PRIC1_ANOGA PRIC1_AEDAE PB25866 PB25868 PHUM142030 GLEAN_09830
Synonyms & Secondary IDs ( 13 )
Reported As
Symbol Synonym	CG11084 (Keleman et al., 2009.8.5, Ni et al., 2010.12.1) CG12830 (Luschnig, 2003.12.17, ) Pk (Torban et al., 2004, Schweisguth et al., 2003, Humbert et al., 2006, Chung et al., 2008, Collier et al., 2008, Fanto and McNeill, 2004, Ma et al., 2008, Matsubara et al., 2011) pk (Lawrence et al., 2004, Lawrence et al., 2007, Ren et al., 2006, Jenny et al., 2003, Strutt et al., 2006, Strutt and Strutt, 2005, König T et al., 2007, Classen et al., 2005, Mirkovic et al., 2011, Olguín et al., 2011, Luo et al., 2011, Chung et al., 2007, Jenny et al., 2005, Dahmann et al., 2008, Shimada et al., 2006, Le Garrec et al., 2006, Rawls et al., 2007, Chen et al., 2008, Fiehler and Wolff, 2007, Fiehler and Wolff, 2008, Shirai et al., 2007, Price et al., 2006, Strutt and Strutt, 2008, Lin and Gubb, 2009, He and Adler, 2002, Strutt and Warrington, 2008, Fetting et al., 2009, Chung et al., 2009, Doyle et al., 2008, Zhou et al., 2008, Pataki et al., 2010, Djiane and Mlodzik, 2010, Lu et al., 2010, Mourikis et al., 2010, Beltran et al., 2007, Hazelett et al., 2009, Hogan et al., 2011, Mirkovic et al., 2011) pk-sple (Das et al., 2004, Strutt et al., 2002, Mlodzik, 1999, Boutros and Mlodzik, 1999, Gubb, 1998, Lawrence et al., 2004, Montrasio et al., 2007) Pk-Sple (Eaton, 2003) sple (Collier et al., 2005, Strutt et al., 2002, del Alamo et al., 2002, Meinertzhagen, 2000, Clandinin and Zipursky, 2000, Cooper and Bray, 1999, Goldschmidt, 1944, Choi et al., 1996, Zheng et al., 1995, Gubb and Green, 1995, Craymer, 1980, Grau and Simpson, 1987, Lin and Gubb, 2009, Doyle et al., 2008) Sple (Doyle and Collier, 2008, Collier et al., 2008)
Name Synonym	Prickle (Djiane et al., 2006, Singla, 2006, Strutt, 2005, Chung et al., 2008, Collier et al., 2008, Fanto and McNeill, 2004, Kerszberg and Wolpert, 2007, Strutt and Strutt, 2007, Chen et al., 2008, Strutt and Strutt, 2008, Doyle et al., 2008, Hogan et al., 2011, Matsubara et al., 2011) prickle (Lawrence et al., 2007, Leptin, 2005, Burnette, 2005, Strutt et al., 2006, Quaiser, 2006, Strutt and Strutt, 2005, Gordon and Nusse, 2006, Doyle and Collier, 2008, Le Garrec et al., 2006, Fiehler and Wolff, 2007, He and Adler, 2002, Fetting et al., 2009, Pataki et al., 2010, Held, 2005, Mourikis et al., 2010) prickle-spiny legs (Ackley and Jin, 2004, Mlodzik, 2002) prickle-spiny-legs (Lin and Gubb, 2003, Cadigan, 2002, Strutt and Strutt, 1999) spiny legs
Secondary FlyBase IDs
	FBgn0003477 FBgn0033151 FBgn0040783
References ( 209 )
Generate a list of	All references relating to this gene ( 209 )
List References by type	Research paper  ( 87 ) Supplementary material  ( 7 ) Review  ( 42 ) Personal communication to FlyBase  ( 18 ) Abstract  ( 42 ) FlyBase analysis  ( 3 ) Conference report  ( 4 ) Book  ( 2 ) DNA/RNA sequence record  ( 1 ) Computer file  ( 2 )
Recent research papers ( 9 )
	Hogan et al., 2011, PLoS Genet. 7(2): e1001305 Two frizzled planar cell polarity signals in the Drosophila wing are differentially organized by the fat/dachsous pathway. [FBrf0213159] Luo et al., 2011, Development 138(13): 2761--2771 Direct targets of the D. melanogaster DSXF protein and the evolution of sexual development. [FBrf0213878] Matsubara et al., 2011, Genes Dev. 25(18): 1982--1996 The seven-pass transmembrane cadherin Flamingo controls dendritic self-avoidance via its binding to a LIM domain protein, Espinas, in Drosophila sensory neurons. [FBrf0215818] Mirkovic et al., 2011, Nat. Struct. Mol. Biol. 18(6): 665--672 Nemo kinase phosphorylates β-catenin to promote ommatidial rotation and connects core PCP factors to E-cadherin-β-catenin. [FBrf0213849] Strutt et al., 2011, Dev. Cell 20(4): 511--525 Dynamics of core planar polarity protein turnover and stable assembly into discrete membrane subdomains. [FBrf0214246] Djiane and Mlodzik, 2010, PLoS ONE 5(6): e11228 The Drosophila GIPC homologue can modulate myosin based processes and planar cell polarity but is not essential for development. [FBrf0211141] Lu et al., 2010, Genetics 185(2): 549--558 The Drosophila planar polarity proteins inturned and multiple wing hairs interact physically and function together. [FBrf0211207] Mourikis et al., 2010, BMC Dev. Biol. 10: 107 Modifiers of notch transcriptional activity identified by genome-wide RNAi. [FBrf0212287] Pataki et al., 2010, Genetics 184(4): 1051--1065 Drosophila Rab23 is involved in the regulation of the number and planar polarization of the adult cuticular hairs. [FBrf0210720] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2010 Show reviews ...