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General Information
Symbol
Dmel\pk
Species
D. melanogaster
Name
prickle
Annotation Symbol
CG11084
Feature Type
FlyBase ID
FBgn0003090
Gene Model Status
Stock Availability
Gene Snapshot
prickle (pk) encodes a core component of the Frizzled-dependent planar polarity complex, which localises to cell junctions in developing epithelia, most likely via direct protein-protein interactions with the transmembrane proteins encoded by Vang and stan. pk product contributes to planar polarity defects in epithelia, as well as nervous system development. [Date last reviewed: 2018-09-20]
Also Known As
sple, pk-sple, prickle-spiny-legs, prickle-spiny legs
Key Links
Genomic Location
Cytogenetic map
Sequence location
2R:7,150,703..7,223,378 [+]
Recombination map
2-55
Sequence
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
Function
GO Summary Ribbons
Protein Family (UniProt)
Belongs to the prickle / espinas / testin family. (A1Z6W3)
Molecular Function (GO)
[Detailed GO annotations]
Experimental Evidence
Predictions / Assertions
Summaries
Protein Function (UniProtKB)
Acts in a planar cell polarity (PCP) complex; polarization along the apical/basal axis of epithelial cells. Correct expression of the alternative isoforms is required for PCP signaling in imaginal disks. PCP signaling in the wing disk requires the receptor fz and the cytoplasmic proteins dsh and pk. These act in a feedback loop leading to activation of the jnk cascade and subsequent polarized arrangement of hairs and bristles. Dgo and pk compete with one another for dsh binding, thereby modulating fz dsh activity and ensuring tight control over fz PCP signaling. Vang, stan and pk function together to regulate the establishment of tissue polarity in the adult eye.
(UniProt, A1Z6W3)
Phenotypic Description (Red Book; Lindsley and Zimm 1992)
pk: prickle
Polarity pattern of wing, haltere, and notum altered in mutants. Chaetae of triple row on anterior wing slanted anteriorly instead of posteriorly. Trichomes near L2 vein arranged in counterclockwise whorl on right wing blade, in clockwise whorl on left blade; trichomes in anterior wing occasionally duplicated (Gubb and Garcia-Bellido, 1982). On the notum, the posterior acrostichals are irregularly erect and whorled. Occasionally, extra dorsocentral and scutellar bristles appear at temperatures above 23. Mutant flies slightly larger than wild type. Gubb and Garcia-Bellido (1982) describe somatic clones of homozygous pk cells.
sple: spiny legs
Polarity of chaetae and trichomes on legs irregular; relations between bracts and bristles disrupted. High incidence of ectopic tarsal joints with inverted polarity, especially in tarsae 3 and 4; incomplete intersegmental membranes between tarsal segments, especially between segments 3 and 4; no extra sensilla companiformia despite extra joints. Chaetae on abdominal tergites turned toward midline instead of pointing posteriorly as in wild type; polarity of bristles on sternites disrupted as well.
sple3
A low-temperature-sensitive allele. Legs of flies raised at 19 highly condensed with incomplete joints, haphazard bristle pattern, occasional increase in number of bristle rows, and absence of some prominent markers. Flies unable to walk and soon get stuck in food. In sple3 flies raised at 28 53% of legs, though apparently normal, display abnormalities such as swollen second, third, and fourth tarsal segments, abnormal tarsal joints and reversals in bristle orientation in the middle of every segment; such flies able to walk and breed. About 30% of legs show phenotype intermediate between the two phenotypes described above. Mutant phenotype expressed in the homeotic legs of Antp and ssa; also expressed in mitotic clones.
Summary (Interactive Fly)
LIM domain protein - a tissue polarity protein - in the Dachsous-Fat system, Dachsous and Dachs, each independently interacts with the Spiny-legs isoform of Prickle and direct Spiny-legs localization in vivo
Gene Model and Products
Number of Transcripts
3
Number of Unique Polypeptides
3

Please see the GBrowse view of Dmel\pk or the JBrowse view of Dmel\pk for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model
Low-frequency RNA-Seq exon junction(s) not annotated.
Gene model reviewed during 5.48
Sequence Ontology: Class of Gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
FBtr0089042
4241
963
FBtr0089043
4109
1029
FBtr0089044
5224
1299
Additional Transcript Data and Comments
Reported size (kB)
5.1, 4.2 (northern blot)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
FBpp0088113
104.7
963
7.23
FBpp0088114
111.8
1029
6.94
FBpp0088115
140.7
1299
6.87
Polypeptides with Identical Sequences

None of the polypeptides share 100% sequence identity.

Additional Polypeptide Data and Comments
Reported size (kDa)
1206, 936, 870 (aa)
Comments
External Data
Subunit Structure (UniProtKB)
Interacts with dsh; PET and LIM domains interact with dsh DEP domain, in wing cells. Interacts with Vang in photoreceptor cells.
(UniProt, A1Z6W3)
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\pk using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Gene Ontology (18 terms)
Molecular Function (2 terms)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
inferred from physical interaction with UniProtKB:P51140
(assigned by UniProt )
inferred from physical interaction with UniProtKB:A1Z7N9
(assigned by UniProt )
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
inferred from electronic annotation with InterPro:IPR001781, InterPro:IPR010442
(assigned by InterPro )
Biological Process (13 terms)
Terms Based on Experimental Evidence (11 terms)
CV Term
Evidence
References
Terms Based on Predictions or Assertions (4 terms)
CV Term
Evidence
References
Cellular Component (3 terms)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
inferred from direct assay
(assigned by UniProt )
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
traceable author statement
non-traceable author statement
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
leg

Comment: reference states 28-34 hr APF

wing

Comment: reference states 28-34 hr APF

Additional Descriptive Data
In 28-34hr pupal wings, pk transcripts are expressed uniformly in intervein cells but not in presumptive vein regions. In pupal legs, transcripts are uniform in most cells but are excluded from the segmental boundaries. Low levels are detected in restricted domains in larval imaginal discs. In the eye disc, expression is detected in a stripe of cells behind the morphogenetic furrow. In wing discs, expression is higher along the dorsoventral compartment boundary. In embryos, a dynamic expression pattern is observed. Expression is highest in cells engaged in morphogenetic movements such as invaginating midline cells, the cephalic fold, and at parasegmental boundaries. Expression of the "pk" and "sple" isoforms is indistinguishable.
"pkM" transcripts are detected only in embryos.
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
immunolocalization
Stage
Tissue/Position (including subcellular localization)
Reference
Additional Descriptive Data
pk protein is expressed in the cytoplasm of all sensory neurons and their axons and in the epidermis from embryonic stage 13 on through embryogenesis. It is also expressed in motor axons including motor nerve SNa in stage 16 embryos. High levels of pk are seen in the dendrites of chordotonal neurons at this stage.
In wandering third instar larvae, pk is localized in the optic lobes as well as in central brain structures between the lobes, and to part of the ventral segmental ganglia.
Marker for
 
Subcellular Localization
CV Term
Evidence
References
inferred from direct assay
(assigned by UniProt )
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\pk in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
Flygut - An atlas of the Drosophila adult midgut
Images
Alleles, Insertions, and Transgenic Constructs
Classical and Insertion Alleles ( 100 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 26 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of pk
Transgenic constructs containing regulatory region of pk
Deletions and Duplications ( 102 )
Disrupted in
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
Sterility
Allele
Other Phenotypes
Allele
Phenotype manifest in
Allele
abdomen & macrochaeta
abdominal sternite & macrochaeta
abdominal tergite & macrochaeta
mesothoracic tergum & sensory mother cell & spindle
tarsal segment 1 & joint
tarsal segment 1 & joint, with Scer\GAL4C-765
tarsal segment 1 & joint, with Scer\GAL4da.G32
tarsal segment 3 & joint
tarsal segment 4 & joint
tarsal segment & joint
trichome & adult abdomen
trichome & adult abdomen | somatic clone | cell autonomous
trichome & costal cell
wing & cell
wing & pupa & cell, with Scer\GAL4en-e16E
wing hair & 1st posterior cell, with Scer\GAL4ptc-559.1
wing hair & cell & pupa, with Scer\GAL4en-e16E
Orthologs
Human Orthologs (via DIOPT v7.1)
Homo sapiens (Human) (11)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Alignment
Complementation?
Transgene?
11 of 15
Yes
Yes
11 of 15
Yes
Yes
8 of 15
No
Yes
 
3 of 15
No
Yes
2 of 15
No
No
2 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
Yes
Model Organism Orthologs (via DIOPT v7.1)
Mus musculus (laboratory mouse) (13)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Alignment
Complementation?
Transgene?
11 of 15
Yes
Yes
11 of 15
Yes
Yes
7 of 15
No
Yes
3 of 15
No
Yes
2 of 15
No
No
2 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
Yes
Rattus norvegicus (Norway rat) (12)
10 of 13
Yes
Yes
10 of 13
Yes
Yes
6 of 13
No
Yes
2 of 13
No
No
2 of 13
No
No
2 of 13
No
Yes
1 of 13
No
No
1 of 13
No
No
1 of 13
No
No
1 of 13
No
No
1 of 13
No
No
1 of 13
No
No
Xenopus tropicalis (Western clawed frog) (8)
8 of 12
Yes
Yes
5 of 12
No
Yes
2 of 12
No
No
1 of 12
No
No
1 of 12
No
Yes
1 of 12
No
No
1 of 12
No
Yes
1 of 12
No
Yes
Danio rerio (Zebrafish) (19)
11 of 15
Yes
Yes
11 of 15
Yes
Yes
9 of 15
No
Yes
7 of 15
No
Yes
6 of 15
No
Yes
2 of 15
No
Yes
2 of 15
No
No
1 of 15
No
Yes
1 of 15
No
Yes
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
Yes
1 of 15
No
No
1 of 15
No
Yes
1 of 15
No
No
1 of 15
No
No
1 of 15
No
Yes
1 of 15
No
Yes
Caenorhabditis elegans (Nematode, roundworm) (4)
9 of 15
Yes
Yes
2 of 15
No
No
2 of 15
No
No
1 of 15
No
Yes
Arabidopsis thaliana (thale-cress) (1)
1 of 9
Yes
No
Saccharomyces cerevisiae (Brewer's yeast) (3)
1 of 15
Yes
No
1 of 15
Yes
No
1 of 15
Yes
No
Schizosaccharomyces pombe (Fission yeast) (0)
No records found.
Orthologs in Drosophila Species (via OrthoDB v9.1) ( EOG091901TV )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila melanogaster
fruit fly
Drosophila suzukii
Spotted wing Drosophila
Drosophila simulans
Drosophila sechellia
Drosophila erecta
Drosophila yakuba
Drosophila ananassae
Drosophila pseudoobscura pseudoobscura
Drosophila persimilis
Drosophila willistoni
Drosophila virilis
Drosophila mojavensis
Drosophila grimshawi
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG0915011V )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Musca domestica
House fly
Lucilia cuprina
Australian sheep blowfly
Lucilia cuprina
Australian sheep blowfly
Aedes aegypti
Yellow fever mosquito
Anopheles darlingi
American malaria mosquito
Culex quinquefasciatus
Southern house mosquito
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W01M8 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Bombyx mori
Silkmoth
Bombyx mori
Silkmoth
Danaus plexippus
Monarch butterfly
Danaus plexippus
Monarch butterfly
Heliconius melpomene
Postman butterfly
Heliconius melpomene
Postman butterfly
Apis florea
Little honeybee
Apis mellifera
Western honey bee
Bombus impatiens
Common eastern bumble bee
Bombus terrestris
Buff-tailed bumblebee
Linepithema humile
Argentine ant
Megachile rotundata
Alfalfa leafcutting bee
Nasonia vitripennis
Parasitic wasp
Dendroctonus ponderosae
Mountain pine beetle
Tribolium castaneum
Red flour beetle
Pediculus humanus
Human body louse
Rhodnius prolixus
Kissing bug
Cimex lectularius
Bed bug
Acyrthosiphon pisum
Pea aphid
Acyrthosiphon pisum
Pea aphid
Zootermopsis nevadensis
Nevada dampwood termite
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X01K8 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strigamia maritima
European centipede
Ixodes scapularis
Black-legged tick
Stegodyphus mimosarum
African social velvet spider
Tetranychus urticae
Two-spotted spider mite
Daphnia pulex
Water flea
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G07C5 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strongylocentrotus purpuratus
Purple sea urchin
Strongylocentrotus purpuratus
Purple sea urchin
Strongylocentrotus purpuratus
Purple sea urchin
Ciona intestinalis
Vase tunicate
Ciona intestinalis
Vase tunicate
Ciona intestinalis
Vase tunicate
Gallus gallus
Domestic chicken
Gallus gallus
Domestic chicken
Gallus gallus
Domestic chicken
Gallus gallus
Domestic chicken
Gallus gallus
Domestic chicken
Gallus gallus
Domestic chicken
Gallus gallus
Domestic chicken
Gallus gallus
Domestic chicken
Gallus gallus
Domestic chicken
Paralogs
Paralogs (via DIOPT v7.1)
Drosophila melanogaster (Fruit fly) (2)
8 of 10
2 of 10
Human Disease Associations
FlyBase Human Disease Model Reports
Disease Model Summary Ribbon
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 3 )
Potential Models Based on Orthology ( 1 )
Modifiers Based on Experimental Evidence ( 1 )
Allele
Disease
Interaction
References
model of  epilepsy
is ameliorated by fafBX4
is ameliorated by fafB3
is ameliorated by fafBX3
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease Associations of Human Orthologs (via DIOPT v7.1 and OMIM)
Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
Functional Complementation Data
Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
Interactions
Summary of Physical Interactions
Summary of Genetic Interactions
esyN Network Diagram
esyN Network Key:
Suppression
Enhancement

Please look at the allele data for full details of the genetic interactions
Starting gene(s)
Interaction type
Interacting gene(s)
Reference
Starting gene(s)
Interaction type
Interacting gene(s)
Reference
External Data
Subunit Structure (UniProtKB)
Interacts with dsh; PET and LIM domains interact with dsh DEP domain, in wing cells. Interacts with Vang in photoreceptor cells.
(UniProt, A1Z6W3 )
Linkouts
BioGRID - A database of protein and genetic interactions.
DroID - A comprehensive database of gene and protein interactions.
InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
MIST (genetic) - An integrated Molecular Interaction Database
MIST (protein-protein) - An integrated Molecular Interaction Database
Pathways
Genomic Location and Detailed Mapping Data
Chromosome (arm)
2R
Recombination map
2-55
Cytogenetic map
Sequence location
2R:7,150,703..7,223,378 [+]
FlyBase Computed Cytological Location
Cytogenetic map
Evidence for location
42F3-43A1
Limits computationally determined from genome sequence between P{lacW}vimark16722 and P{lacW}cosk16101
Experimentally Determined Cytological Location
Cytogenetic map
Notes
References
43A1-43A2
Placed in 42E3--43C3 by deficiency mapping. This cytological map position does not agree with FBrf0020044.
Experimentally Determined Recombination Data
Right of (cM)
Notes
The cellular polarity gene pk and the adult lethal nec gene map within the proximal region of pk-sple complex among a set of 3 Serpin transcripts.
Alleles of the 'prickle' phenotypic class map to the left of alleles of the 'sple' phenotypic class.
Genetic map position is approximate.
Stocks and Reagents
Stocks (60)
Genomic Clones (45)
cDNA Clones (117)
 

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequences
BDGP DGC clones
Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

cDNA Clones, End Sequenced (ESTs)
RNAi and Array Information
Linkouts
DRSC - Results frm RNAi screens
GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
Antibody Information
Laboratory Generated Antibodies
Commercially Available Antibodies
 
Other Information
Relationship to Other Genes
Source for database identify of
Source for database merge of
Source for merge of: pk CG11084
Source for merge of: pk CG12830
Additional comments
Annotations CG12830 and CG11084 merged as CG11084 (which corresponds to pk) in release 3 of the genome annotation.
Other Comments
During development of the bristle lineage, Vang protein is localised in an anterior crescent in dividing sensillum precursor cells.
Mutations in fz-like class of genes fz, pk, Vang, stan and dsh act as strong enhancers of weak in or fy phenotypes.
in and fy are needed for cells to respond to pk and stan. Genetic analysis is not consistent with fz-like class of genes fz, pk, Vang, stan and dsh acting simply as positive or negative regulators of in and fy.
pk is required for a feedback loop that generates asymmetric planar cell polarity signalling in the wing.
The "Pk" class of alleles carry molecular lesions within the proximal 30kb of the transcription unit, whereas the "Pk-Sple" class of alleles map to the distal section of the transcription unit. In direction of increasing cytology: Spn43Aa+ pk+ Spn43Ab- nec- pk+ Ady43A-
Alleles can be divided into three phenotypic classes, "Pk", "Pk-Sple", and "Sple". No allele causes an embryonic phenotype, even when homozygous mutant embryos develop from homozygous mutant mothers. Deletions of the pk gene are fully viable and fertile. The defects of the double mutant "Pk-Sple" class are the same as those seen with deletions of the entire gene. Paradoxically the "Pk" and "Sple" classes give more severe phenotypes with "Pk" affecting the wing and notum and "Sple" in the legs abdomen and eyes.
The balance between the pk isoforms "Pk" and "Sple" is critical for the specification of planar polarity.
pk is a slightly haploinsufficient gene. A deficiency for pk (and some pk point mutants) shows a weak, partially penetrant dominant tissue polarity phenotype. This effect is enhanced by several Vang alleles. Phenotypic data suggest that genetics of Vang and its interactions with pk are complex. Several, but not all, Vang alleles act as enhancers of the pk haploinsufficient tissue polarity phenotype, and the pkTBJ21 antimorphic phenotype. Mutations in pk can also act as suppressors of Vang dominant phenotypes.
Mutants do not exhibit defects in the denticle belt of hairs of the larvae.
In pk mutants the dorsal/ventral boundary in the eye is respected but the mechanism for ommatidial polarization is perturbed. A likely explanation for the observed phenotype is that the fates of dorsal and ventral cells within a cluster have been interchanged.
Mosaic analysis demonstrates pk function in either R3, R4 or R5 photoreceptor cell appears to be sufficient to drive an ommatidium in the right direction.
Polarity pattern of wing, haltere and notum altered. Triple row bristles on anterior wing slanted proximally instead of distally. On the notum, the posterior acrostichal bristles are whorled.
Trichomes near L2 vein arranged in counterclockwise whorl on right wing blade, in clockwise whorl on left blade; trichomes in anterior wing occasionally duplicated. Somatic clones of homozygous pk mutant cells have been generated. Not a vital locus.
"AQ254872; BDGP:EP (2)2557" was stated as revision.
Origin and Etymology
Discoverer
Ives, Nov. 1938.
Etymology
Identification
External Crossreferences and Linkouts ( 66 )
Sequence Crossreferences
NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
Other crossreferences
Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Flygut - An atlas of the Drosophila adult midgut
Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
InterPro - A database of protein families, domains and functional sites
KEGG Genes - Molecular building blocks of life in the genomic space.
KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.
modMine - A data warehouse for the modENCODE project
Linkouts
BioGRID - A database of protein and genetic interactions.
DroID - A comprehensive database of gene and protein interactions.
DRSC - Results frm RNAi screens
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
FlyMine - An integrated database for Drosophila genomics
Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.
MIST (genetic) - An integrated Molecular Interaction Database
MIST (protein-protein) - An integrated Molecular Interaction Database
Synonyms and Secondary IDs (16)
Reported As
Symbol Synonym
pk
(Maier, 2019, Meltzer, 2019-, Meltzer et al., 2019, Strutt et al., 2019, Collu et al., 2018, Ikawa and Sugimura, 2018, Johan Arief et al., 2018, Franz et al., 2017, Transgenic RNAi Project members, 2017-, Carvajal-Gonzalez et al., 2016, Gene Disruption Project members, 2016-, Duff et al., 2015, Galic and Matis, 2015, Gombos et al., 2015, Kroll et al., 2015, Morozova et al., 2015, Paemka et al., 2015, Yang and Mlodzik, 2015, Zirin et al., 2015, Ayukawa et al., 2014, Ehaideb et al., 2014, Guarner et al., 2014, Vernes, 2014, Wang et al., 2014, Lawrence and Casal, 2013, Podratz et al., 2013, Strutt et al., 2013, Strutt et al., 2013, Butchar et al., 2012, Capilla et al., 2012, Daulat et al., 2012, Kuroda et al., 2012, Muñoz-Soriano et al., 2012, Weber et al., 2012, Goodrich and Strutt, 2011, Hogan et al., 2011, Luo et al., 2011, Mirkovic et al., 2011, Mirkovic et al., 2011, Mrkusich et al., 2011, Olguín et al., 2011, Shimizu et al., 2011, Tao et al., 2011, Djiane and Mlodzik, 2010, Lu et al., 2010, Mourikis et al., 2010, Pataki et al., 2010, Silicheva et al., 2010, Chung et al., 2009, Fetting et al., 2009, Hazelett et al., 2009, Lin and Gubb, 2009, Zhu, 2009, Chen et al., 2008, Dahmann et al., 2008, Doyle et al., 2008, Fiehler and Wolff, 2008, Strutt and Strutt, 2008, Strutt and Warrington, 2008, Zhou et al., 2008, Beltran et al., 2007, Chung et al., 2007, Fiehler and Wolff, 2007, König et al., 2007, Lawrence et al., 2007, Muñoz-Descalzo et al., 2007, Rawls et al., 2007, Shirai et al., 2007, Strutt and Strutt, 2007, Le Garrec et al., 2006, Price et al., 2006, Ren et al., 2006, Shimada et al., 2006, Strutt et al., 2006, Brown and Feder, 2005, Classen et al., 2005, Jenny et al., 2005, Strutt and Strutt, 2005, Lawrence et al., 2004, Jenny et al., 2003, He and Adler, 2002)
Secondary FlyBase IDs
  • FBgn0003477
  • FBgn0033151
  • FBgn0040783
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References (312)