A Database of Drosophila Genes & Genomes

FB2013_03, released May 7th, 2013
 

Gene Dmel\pk

General Information
SymbolDmel\pkSpeciesD. melanogaster
NameprickleAnnotation symbolCG11084
Feature typeprotein_coding_geneFlyBase IDFBgn0003090
Gene Model StatusCurrent Stock availability 50 publicly available
Also Known Assple, pk-sple
Genomic Location
Chromosome (arm)2RRecombination map2-55.3
Cytogenetic map42F3-43A1Sequence location2R:3,038,208..3,110,883 [+]

Genomic Maps

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Automatically generated summary

See sections below for more information
The gene prickle is referred to in FlyBase by the symbol Dmel\pk (CG11084, FBgn0003090). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: protein binding. There is experimental evidence that it is involved in the biological process: establishment or maintenance of cell polarity; establishment of imaginal disc-derived wing hair orientation; establishment of ommatidial planar polarity; morphogenesis of a polarized epithelium. 102 alleles are reported. The phenotypes of these alleles are annotated with: adult segment; organ system subdivision; organ system; thoracic segment; appendage segment; external compound sense organ; metatarsus; integumentary specialisation; peripheral nervous system; acellular anatomical structure; sense organ. It has 3 annotated transcripts and 3 annotated polypeptides. Protein features are: PET domain; Zinc finger, LIM-type. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of very low expression. Peak expression observed within 06-18 hour embryonic stages, at stages throughout the pupal period. Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: larval central nervous system. Comments on Affy2 ProbeSet: ProbeSet 1636612_a_at completely aligns to an exonic region common to each of the 3 FlyBase-annotated transcript isoforms of pk. Gene sequence location is 2R:3038208..3110883.

User Contributed Data
External Summaries
hide Phenotypic Description from the Red Book (Lindsley & Zimm 1992)
Gene/Allele symbols may differ from current usage
pk: prickle
Polarity pattern of wing, haltere, and notum altered in mutants. Chaetae of triple row on anterior wing slanted anteriorly instead of posteriorly. Trichomes near L2 vein arranged in counterclockwise whorl on right wing blade, in clockwise whorl on left blade; trichomes in anterior wing occasionally duplicated (Gubb and Garcia-Bellido, 1982). On the notum, the posterior acrostichals are irregularly erect and whorled. Occasionally, extra dorsocentral and scutellar bristles appear at temperatures above 23. Mutant flies slightly larger than wild type. Gubb and Garcia-Bellido (1982) describe somatic clones of homozygous pk cells.
sple: spiny legs
Polarity of chaetae and trichomes on legs irregular; relations between bracts and bristles disrupted. High incidence of ectopic tarsal joints with inverted polarity, especially in tarsae 3 and 4; incomplete intersegmental membranes between tarsal segments, especially between segments 3 and 4; no extra sensilla companiformia despite extra joints. Chaetae on abdominal tergites turned toward midline instead of pointing posteriorly as in wild type; polarity of bristles on sternites disrupted as well.
sple3
A low-temperature-sensitive allele. Legs of flies raised at 19 highly condensed with incomplete joints, haphazard bristle pattern, occasional increase in number of bristle rows, and absence of some prominent markers. Flies unable to walk and soon get stuck in food. In sple3 flies raised at 28 53% of legs, though apparently normal, display abnormalities such as swollen second, third, and fourth tarsal segments, abnormal tarsal joints and reversals in bristle orientation in the middle of every segment; such flies able to walk and breed. About 30% of legs show phenotype intermediate between the two phenotypes described above. Mutant phenotype expressed in the homeotic legs of Antp and ssa; also expressed in mitotic clones.
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Description
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FB2013_03
Alleles
FB2013_02
All updates Click here to see a list of all updates to this record from FB2010_08 and on.
hide Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map
Evidence for location
42F3-43A1  
Limits computationally determined from genome sequence between P{lacW}vimark16722 and P{lacW}cosk16101  
Experimentally Determined Cytological Location
Cytogenetic map
Notes
References
43A1-43A2  
42E3-43C3  
Placed in 42E3--43C3 by deficiency mapping. This cytological map position does not agree with FBrf0020044.  
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Genetic map position is approximate.
Alleles of the 'prickle' phenotypic class map to the left of alleles of the 'sple' phenotypic class.
The cellular polarity gene pk and the adult lethal nec gene map within the proximal region of pk-sple complex among a set of 3 Serpin transcripts.
hide Gene Model & Products
Please see the GBrowse view of Dmel\pk for information on other features GBrowse View Help
To submit a correction to a gene model please use the Contact FlyBase form
detailed view FBtr0089041 FBtr0112770 FBtr0336881 FBtr0089042 FBtr0100356 FBtr0089053 FBtr0089052 FBtr0089043 FBtr0089045 FBtr0089046 FBtr0089047 FBtr0089048 FBtr0089044 FBpp0088112 FBpp0111682 FBpp0088113 FBpp0099762 FBpp0088124 FBpp0088123 FBpp0088114 FBpp0088116 FBpp0088117 FBpp0088118 FBpp0088119 FBpp0088115 FBti0070669 FBti0068481 FBti0017688 FBti0070444 FBti0054787 FBti0143194 FBti0076107 FBti0113487 FBti0042626 FBti0127642 FBti0042314 FBti0124998 FBti0011235 FBti0026352 FBti0028277 FBti0106492 FBti0111827 FBti0024521 FBti0054459 FBti0037389 FBti0151839 FBti0034927 FBti0046109 FBti0066172 FBti0066173 FBti0143316 FBti0076436
Comments on Gene Model
Low-frequency RNA-Seq exon junction(s) not annotated.
Gene model reviewed during 5.48
hide Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Associated CDS (aa)
FBtr0089042
  4241
  963
FBtr0089043
  4109
  1029
FBtr0089044
  5224
  1299
Additional Transcript Data & Comments
Reported size (kB)
5.1, 4.2 (northern blot)
Comments
External Data
Crossreferences
hide Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank protein
pk-PA  
FBpp0088113  
104.7  
963  
7.23  
pk-PB  
FBpp0088114  
111.8  
1029  
6.94  
pk-PC  
FBpp0088115  
140.7  
1299  
6.87  
Additional Polypeptide Data & Comments
Reported size (kDa)
1206, 936, 870 (aa)
Comments
External Data
Linkouts
Crossreferences
InterPro domains - A database of protein families, domains, and functional sites
PET domain (IPR010442)
hide Sequences Consistent with the Gene Model
DDBJ /
EMBL /
GenBank
DNA sequence
Protein sequence
Name
 
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL
hide Mapped Features
Mapped Features have been reorganized, please see this article for details.
Additional mapped features and mutations can be found on GBrowse or related reports.
Type
Symbol & Location
Additional Notes
References
hide External Data
Linkouts
Crossreferences
hide Expression Data
hideTranscript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
Comment:reference states 28-34 hr APF
Comment:reference states 28-34 hr APF
Additional Descriptive Data
In 28-34hr pupal wings, pk transcripts are expressed uniformly in intervein cells but not in presumptive vein regions. In pupal legs, transcripts are uniform in most cells but are excluded from the segmental boundaries. Low levels are detected in restricted domains in larval imaginal discs. In the eye disc, expression is detected in a stripe of cells behind the morphogenetic furrow. In wing discs, expression is higher along the dorsoventral compartment boundary. In embryos, a dynamic expression pattern is observed. Expression is highest in cells engaged in morphogenetic movements such as invaginating midline cells, the cephalic fold, and at parasegmental boundaries. Expression of the "pk" and "sple" isoforms is indistinguishable.
"pkM" transcripts are detected only in embryos.
Marker for
Subcellular Localization
CV Term
hide Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term
References
hide Expression Deduced from Reporters
hide High-Throughput Expression Data
Associated Tools
Reference
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
hide FlyAtlas Anatomy Microarray

FlyAtlas Anatomical Expression Data

(FlyAtlas-RNA.adult)

(FlyAtlas-RNA.larva)


   Styles
   Scales

Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: larval central nervous system.
[download data (TSV)]

Guide to FlyAtlas expression level colors
 
No expression (0 - 9.999)
 
Low expression (10 - 99.999)
 
Moderate expression (100 - 499.999)
 
High level expression (500 - 999.999)
 
Very high expression (>999.999)

Linear, scaled to maximum expression level
Tissue   Expression Level
Larval Central Nervous System
 
 199.5
Larval Midgut
 
 7.7
Larval Hindgut
 
 34.3
Larval Malpighian Tubules
 
 4.7
Larval Fat Body
 
 7.1
Larval Salivary Gland
 
 6.5
Larval Trachea
 
 78.275
Larval Carcass
 
 29.675
Adult Head
 
 20.3
Adult Eye
 
 47.4
Adult Brain
 
 17.3
Adult Thoracic-Abdominal Ganglion
 
 16.9
Adult Crop
 
 61.6
Adult Midgut
 
 21.3
Adult Hindgut
 
 42.1
Adult Malpighian Tubules
 
 6
Adult Fat Body
 
 15.3
Adult Salivary Gland
 
 7.8
Adult Heart
 
 4.975
Adult VirginFemale Spermatheca
 
 24.1
Adult InseminatedFemale Spermatheca
 
 21.1
Adult Ovary
 
 6
Adult Testis
 
 9.7
Adult Male Accessory Gland
 
 23.9
Adult Carcass
 
 32.7
Expression Level Scale
 None 
 Low 
 Moderate 
Linear, scaled to Moderate expression
Tissue   Expression Level
Larval Central Nervous System
 
 199.5
Larval Midgut
 
 7.7
Larval Hindgut
 
 34.3
Larval Malpighian Tubules
 
 4.7
Larval Fat Body
 
 7.1
Larval Salivary Gland
 
 6.5
Larval Trachea
 
 78.275
Larval Carcass
 
 29.675
Adult Head
 
 20.3
Adult Eye
 
 47.4
Adult Brain
 
 17.3
Adult Thoracic-Abdominal Ganglion
 
 16.9
Adult Crop
 
 61.6
Adult Midgut
 
 21.3
Adult Hindgut
 
 42.1
Adult Malpighian Tubules
 
 6
Adult Fat Body
 
 15.3
Adult Salivary Gland
 
 7.8
Adult Heart
 
 4.975
Adult VirginFemale Spermatheca
 
 24.1
Adult InseminatedFemale Spermatheca
 
 21.1
Adult Ovary
 
 6
Adult Testis
 
 9.7
Adult Male Accessory Gland
 
 23.9
Adult Carcass
 
 32.7
Expression Level Scale
 None 
 Low 
 Moderate 
 High 
Linear, scaled to High level expression
Tissue   Expression Level
Larval Central Nervous System
 
 199.5
Larval Midgut
 
 7.7
Larval Hindgut
 
 34.3
Larval Malpighian Tubules
 
 4.7
Larval Fat Body
 
 7.1
Larval Salivary Gland
 
 6.5
Larval Trachea
 
 78.275
Larval Carcass
 
 29.675
Adult Head
 
 20.3
Adult Eye
 
 47.4
Adult Brain
 
 17.3
Adult Thoracic-Abdominal Ganglion
 
 16.9
Adult Crop
 
 61.6
Adult Midgut
 
 21.3
Adult Hindgut
 
 42.1
Adult Malpighian Tubules
 
 6
Adult Fat Body
 
 15.3
Adult Salivary Gland
 
 7.8
Adult Heart
 
 4.975
Adult VirginFemale Spermatheca
 
 24.1
Adult InseminatedFemale Spermatheca
 
 21.1
Adult Ovary
 
 6
Adult Testis
 
 9.7
Adult Male Accessory Gland
 
 23.9
Adult Carcass
 
 32.7
Expression Level Scale
 None 
 Low 
 Moderate 
 High 
 Very high 
Linear, scaled to Very high expression
Tissue   Expression Level
Larval Central Nervous System
 
 199.5
Larval Midgut
 
 7.7
Larval Hindgut
 
 34.3
Larval Malpighian Tubules
 
 4.7
Larval Fat Body
 
 7.1
Larval Salivary Gland
 
 6.5
Larval Trachea
 
 78.275
Larval Carcass
 
 29.675
Adult Head
 
 20.3
Adult Eye
 
 47.4
Adult Brain
 
 17.3
Adult Thoracic-Abdominal Ganglion
 
 16.9
Adult Crop
 
 61.6
Adult Midgut
 
 21.3
Adult Hindgut
 
 42.1
Adult Malpighian Tubules
 
 6
Adult Fat Body
 
 15.3
Adult Salivary Gland
 
 7.8
Adult Heart
 
 4.975
Adult VirginFemale Spermatheca
 
 24.1
Adult InseminatedFemale Spermatheca
 
 21.1
Adult Ovary
 
 6
Adult Testis
 
 9.7
Adult Male Accessory Gland
 
 23.9
Adult Carcass
 
 32.7
Expression Level Scale
 Very high 
log, scaled to maximum expression level
Tissue   Expression Level
Larval Central Nervous System
 
 199.5
Larval Midgut
 
 7.7
Larval Hindgut
 
 34.3
Larval Malpighian Tubules
 
 4.7
Larval Fat Body
 
 7.1
Larval Salivary Gland
 
 6.5
Larval Trachea
 
 78.275
Larval Carcass
 
 29.675
Adult Head
 
 20.3
Adult Eye
 
 47.4
Adult Brain
 
 17.3
Adult Thoracic-Abdominal Ganglion
 
 16.9
Adult Crop
 
 61.6
Adult Midgut
 
 21.3
Adult Hindgut
 
 42.1
Adult Malpighian Tubules
 
 6
Adult Fat Body
 
 15.3
Adult Salivary Gland
 
 7.8
Adult Heart
 
 4.975
Adult VirginFemale Spermatheca
 
 24.1
Adult InseminatedFemale Spermatheca
 
 21.1
Adult Ovary
 
 6
Adult Testis
 
 9.7
Adult Male Accessory Gland
 
 23.9
Adult Carcass
 
 32.7
Expression Level Scale
 None 
 Low 
 Moderate 
log, scaled to Moderate expression
Tissue   Expression Level
Larval Central Nervous System
 
 199.5
Larval Midgut
 
 7.7
Larval Hindgut
 
 34.3
Larval Malpighian Tubules
 
 4.7
Larval Fat Body
 
 7.1
Larval Salivary Gland
 
 6.5
Larval Trachea
 
 78.275
Larval Carcass
 
 29.675
Adult Head
 
 20.3
Adult Eye
 
 47.4
Adult Brain
 
 17.3
Adult Thoracic-Abdominal Ganglion
 
 16.9
Adult Crop
 
 61.6
Adult Midgut
 
 21.3
Adult Hindgut
 
 42.1
Adult Malpighian Tubules
 
 6
Adult Fat Body
 
 15.3
Adult Salivary Gland
 
 7.8
Adult Heart
 
 4.975
Adult VirginFemale Spermatheca
 
 24.1
Adult InseminatedFemale Spermatheca
 
 21.1
Adult Ovary
 
 6
Adult Testis
 
 9.7
Adult Male Accessory Gland
 
 23.9
Adult Carcass
 
 32.7
Expression Level Scale
 None 
 Low 
 Moderate 
 High 
log, scaled to High level expression
Tissue   Expression Level
Larval Central Nervous System
 
 199.5
Larval Midgut
 
 7.7
Larval Hindgut
 
 34.3
Larval Malpighian Tubules
 
 4.7
Larval Fat Body
 
 7.1
Larval Salivary Gland
 
 6.5
Larval Trachea
 
 78.275
Larval Carcass
 
 29.675
Adult Head
 
 20.3
Adult Eye
 
 47.4
Adult Brain
 
 17.3
Adult Thoracic-Abdominal Ganglion
 
 16.9
Adult Crop
 
 61.6
Adult Midgut
 
 21.3
Adult Hindgut
 
 42.1
Adult Malpighian Tubules
 
 6
Adult Fat Body
 
 15.3
Adult Salivary Gland
 
 7.8
Adult Heart
 
 4.975
Adult VirginFemale Spermatheca
 
 24.1
Adult InseminatedFemale Spermatheca
 
 21.1
Adult Ovary
 
 6
Adult Testis
 
 9.7
Adult Male Accessory Gland
 
 23.9
Adult Carcass
 
 32.7
Expression Level Scale
 None 
 Low 
 Moderate 
 High 
 Very high 
log, scaled to Very high expression
Tissue   Expression Level
Larval Central Nervous System
 
 199.5
Larval Midgut
 
 7.7
Larval Hindgut
 
 34.3
Larval Malpighian Tubules
 
 4.7
Larval Fat Body
 
 7.1
Larval Salivary Gland
 
 6.5
Larval Trachea
 
 78.275
Larval Carcass
 
 29.675
Adult Head
 
 20.3
Adult Eye
 
 47.4
Adult Brain
 
 17.3
Adult Thoracic-Abdominal Ganglion
 
 16.9
Adult Crop
 
 61.6
Adult Midgut
 
 21.3
Adult Hindgut
 
 42.1
Adult Malpighian Tubules
 
 6
Adult Fat Body
 
 15.3
Adult Salivary Gland
 
 7.8
Adult Heart
 
 4.975
Adult VirginFemale Spermatheca
 
 24.1
Adult InseminatedFemale Spermatheca
 
 21.1
Adult Ovary
 
 6
Adult Testis
 
 9.7
Adult Male Accessory Gland
 
 23.9
Adult Carcass
 
 32.7
Expression Level Scale
 None 
 Low 
 Moderate 
 High 
 Very high 
Heatmap
Tissue   Expression Level
Larval Central Nervous System
 
 
Larval Midgut
 
 
Larval Hindgut
 
 
Larval Malpighian Tubules
 
 
Larval Fat Body
 
 
Larval Salivary Gland
 
 
Larval Trachea
 
 
Larval Carcass
 
 
Adult Head
 
 
Adult Eye
 
 
Adult Brain
 
 
Adult Thoracic-Abdominal Ganglion
 
 
Adult Crop
 
 
Adult Midgut
 
 
Adult Hindgut
 
 
Adult Malpighian Tubules
 
 
Adult Fat Body
 
 
Adult Salivary Gland
 
 
Adult Heart
 
 
Adult VirginFemale Spermatheca
 
 
Adult InseminatedFemale Spermatheca
 
 
Adult Ovary
 
 
Adult Testis
 
 
Adult Male Accessory Gland
 
 
Adult Carcass
 
 

FlyAtlas Organ/Tissue Expression, larval vs. adult
Larval Expression Level Tissue Adult Expression Level
 
NA 
Head
 
 20.3
 
NA 
Eye
 
 47.4
 
NA 
Brain
 
 17.3
 
199.5 
Central Nervous System
 
 NA
 
NA 
Thoracic-Abdominal Ganglion
 
 16.9
 
NA 
Crop
 
 61.6
 
7.7 
Midgut
 
 21.3
 
34.3 
Hindgut
 
 42.1
 
4.7 
Malpighian Tubules
 
 6
 
7.1 
Fat Body
 
 no informative data
 
6.5 
Salivary Gland
 
 7.8
 
NA 
Heart
 
 4.975
 
78.275 
Trachea
 
 NA
 
NA 
VirginFemale Spermatheca
 
 24.1
 
NA 
InseminatedFemale Spermatheca
 
 21.1
 
NA 
Ovary
 
 6
 
NA 
Testis
 
 9.7
 
NA 
Male Accessory Gland
 
 no informative data
 
29.675 
Carcass
 
 32.7

FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
hide modENCODE Anatomy RNA-Seq

modENCODE Tissue Expression Data

(modENCODE_mRNA-Seq_tissues)


   Styles
   Scales


[download data (TSV)]

Guide to modENCODE expression level colors
 
No/Extremely low expression (0 - 0)
 
Very low expression (1 - 3)
 
Low expression (4 - 10)
 
Moderate expression (11 - 25)
 
Moderately high expression (26 - 50)
 
High expression (51 - 100)
 
Very high expression (101 - 1000)
 
Extremely high expression (>1000)

Linear, scaled to maximum expression level
Tissue   Expression Level
imaginal disc, larvae L3 wandering
 
 20
central nervous system, larvae L3
 
 17
central nervous system, pupae P8
 
 4
head, virgin 1-day female
 
 2
head, virgin 4-day female
 
 3
head, virgin 20-day female
 
 2
head, mated 1-day female
 
 2
head, mated 4-day female
 
 2
head, mated 20-day female
 
 2
head, mated 1-day male
 
 4
head, mated 4-day male
 
 3
head, mated 20-day male
 
 2
salivary gland, larvae L3 wandering
 
 0
salivary gland, white prepupae
 
 0
digestive system, larvae L3 wandering
 
 0
digestive system, 1-day adult
 
 1
digestive system, 4-day adult
 
 1
digestive system, 20-day adult
 
 1
fat body, larvae L3 wandering
 
 0
fat body, white prepupae
 
 2
fat body, pupae P8
 
 10
carcass, larvae L3 wandering
 
 10
carcass, 1-day adult
 
 2
carcass, 4-day adult
 
 1
carcass, 20-day adult
 
 2
ovary, virgin 4-day female
 
 0
ovary, mated 4-day female
 
 0
testis, mated 4-day male
 
 1
accessory gland, mated 4-day male
 
 2
Expression Level Scale
 Very low 
 Low 
 Moderate 
Linear, scaled to Moderate expression
Tissue   Expression Level
imaginal disc, larvae L3 wandering
 
 20
central nervous system, larvae L3
 
 17
central nervous system, pupae P8
 
 4
head, virgin 1-day female
 
 2
head, virgin 4-day female
 
 3
head, virgin 20-day female
 
 2
head, mated 1-day female
 
 2
head, mated 4-day female
 
 2
head, mated 20-day female
 
 2
head, mated 1-day male
 
 4
head, mated 4-day male
 
 3
head, mated 20-day male
 
 2
salivary gland, larvae L3 wandering
 
 0
salivary gland, white prepupae
 
 0
digestive system, larvae L3 wandering
 
 0
digestive system, 1-day adult
 
 1
digestive system, 4-day adult
 
 1
digestive system, 20-day adult
 
 1
fat body, larvae L3 wandering
 
 0
fat body, white prepupae
 
 2
fat body, pupae P8
 
 10
carcass, larvae L3 wandering
 
 10
carcass, 1-day adult
 
 2
carcass, 4-day adult
 
 1
carcass, 20-day adult
 
 2
ovary, virgin 4-day female
 
 0
ovary, mated 4-day female
 
 0
testis, mated 4-day male
 
 1
accessory gland, mated 4-day male
 
 2
Expression Level Scale
 Very low 
 Low 
 Moderate 
 Moderately high 
Linear, scaled to High expression
Tissue   Expression Level
imaginal disc, larvae L3 wandering
 
 20
central nervous system, larvae L3
 
 17
central nervous system, pupae P8
 
 4
head, virgin 1-day female
 
 2
head, virgin 4-day female
 
 3
head, virgin 20-day female
 
 2
head, mated 1-day female
 
 2
head, mated 4-day female
 
 2
head, mated 20-day female
 
 2
head, mated 1-day male
 
 4
head, mated 4-day male
 
 3
head, mated 20-day male
 
 2
salivary gland, larvae L3 wandering
 
 0
salivary gland, white prepupae
 
 0
digestive system, larvae L3 wandering
 
 0
digestive system, 1-day adult
 
 1
digestive system, 4-day adult
 
 1
digestive system, 20-day adult
 
 1
fat body, larvae L3 wandering
 
 0
fat body, white prepupae
 
 2
fat body, pupae P8
 
 10
carcass, larvae L3 wandering
 
 10
carcass, 1-day adult
 
 2
carcass, 4-day adult
 
 1
carcass, 20-day adult
 
 2
ovary, virgin 4-day female
 
 0
ovary, mated 4-day female
 
 0
testis, mated 4-day male
 
 1
accessory gland, mated 4-day male
 
 2
Expression Level Scale
 Very low 
 Low 
 Moderate 
 Moderately high 
 High 
 Very high 
Linear, scaled to Extremely high expression
Tissue   Expression Level
imaginal disc, larvae L3 wandering
 
 20
central nervous system, larvae L3
 
 17
central nervous system, pupae P8
 
 4
head, virgin 1-day female
 
 2
head, virgin 4-day female
 
 3
head, virgin 20-day female
 
 2
head, mated 1-day female
 
 2
head, mated 4-day female
 
 2
head, mated 20-day female
 
 2
head, mated 1-day male
 
 4
head, mated 4-day male
 
 3
head, mated 20-day male
 
 2
salivary gland, larvae L3 wandering
 
 0
salivary gland, white prepupae
 
 0
digestive system, larvae L3 wandering
 
 0
digestive system, 1-day adult
 
 1
digestive system, 4-day adult
 
 1
digestive system, 20-day adult
 
 1
fat body, larvae L3 wandering
 
 0
fat body, white prepupae
 
 2
fat body, pupae P8
 
 10
carcass, larvae L3 wandering
 
 10
carcass, 1-day adult
 
 2
carcass, 4-day adult
 
 1
carcass, 20-day adult
 
 2
ovary, virgin 4-day female
 
 0
ovary, mated 4-day female
 
 0
testis, mated 4-day male
 
 1
accessory gland, mated 4-day male
 
 2
Expression Level Scale
 Extremely high 
log, scaled to maximum expression level
Tissue   Expression Level
imaginal disc, larvae L3 wandering
 
 20
central nervous system, larvae L3
 
 17
central nervous system, pupae P8
 
 4
head, virgin 1-day female
 
 2
head, virgin 4-day female
 
 3
head, virgin 20-day female
 
 2
head, mated 1-day female
 
 2
head, mated 4-day female
 
 2
head, mated 20-day female
 
 2
head, mated 1-day male
 
 4
head, mated 4-day male
 
 3
head, mated 20-day male
 
 2
salivary gland, larvae L3 wandering
 
 0
salivary gland, white prepupae
 
 0
digestive system, larvae L3 wandering
 
 0
digestive system, 1-day adult
 
 1
digestive system, 4-day adult
 
 1
digestive system, 20-day adult
 
 1
fat body, larvae L3 wandering
 
 0
fat body, white prepupae
 
 2
fat body, pupae P8
 
 10
carcass, larvae L3 wandering
 
 10
carcass, 1-day adult
 
 2
carcass, 4-day adult
 
 1
carcass, 20-day adult
 
 2
ovary, virgin 4-day female
 
 0
ovary, mated 4-day female
 
 0
testis, mated 4-day male
 
 1
accessory gland, mated 4-day male
 
 2
Expression Level Scale
 Very low 
 Low 
 Moderate 
 Moderately high 
log, scaled to Moderate expression
Tissue   Expression Level
imaginal disc, larvae L3 wandering
 
 20
central nervous system, larvae L3
 
 17
central nervous system, pupae P8
 
 4
head, virgin 1-day female
 
 2
head, virgin 4-day female
 
 3
head, virgin 20-day female
 
 2
head, mated 1-day female
 
 2
head, mated 4-day female
 
 2
head, mated 20-day female
 
 2
head, mated 1-day male
 
 4
head, mated 4-day male
 
 3
head, mated 20-day male
 
 2
salivary gland, larvae L3 wandering
 
 0
salivary gland, white prepupae
 
 0
digestive system, larvae L3 wandering
 
 0
digestive system, 1-day adult
 
 1
digestive system, 4-day adult
 
 1
digestive system, 20-day adult
 
 1
fat body, larvae L3 wandering
 
 0
fat body, white prepupae
 
 2
fat body, pupae P8
 
 10
carcass, larvae L3 wandering
 
 10
carcass, 1-day adult
 
 2
carcass, 4-day adult
 
 1
carcass, 20-day adult
 
 2
ovary, virgin 4-day female
 
 0
ovary, mated 4-day female
 
 0
testis, mated 4-day male
 
 1
accessory gland, mated 4-day male
 
 2
Expression Level Scale
 Very low 
 Low 
 Moderate 
 Moderately high 
log, scaled to High expression
Tissue   Expression Level
imaginal disc, larvae L3 wandering
 
 20
central nervous system, larvae L3
 
 17
central nervous system, pupae P8
 
 4
head, virgin 1-day female
 
 2
head, virgin 4-day female
 
 3
head, virgin 20-day female
 
 2
head, mated 1-day female
 
 2
head, mated 4-day female
 
 2
head, mated 20-day female
 
 2
head, mated 1-day male
 
 4
head, mated 4-day male
 
 3
head, mated 20-day male
 
 2
salivary gland, larvae L3 wandering
 
 0
salivary gland, white prepupae
 
 0
digestive system, larvae L3 wandering
 
 0
digestive system, 1-day adult
 
 1
digestive system, 4-day adult
 
 1
digestive system, 20-day adult
 
 1
fat body, larvae L3 wandering
 
 0
fat body, white prepupae
 
 2
fat body, pupae P8
 
 10
carcass, larvae L3 wandering
 
 10
carcass, 1-day adult
 
 2
carcass, 4-day adult
 
 1
carcass, 20-day adult
 
 2
ovary, virgin 4-day female
 
 0
ovary, mated 4-day female
 
 0
testis, mated 4-day male
 
 1
accessory gland, mated 4-day male
 
 2
Expression Level Scale
 Very low 
 Low 
 Moderate 
 Moderately high 
 High 
 Very high 
log, scaled to Extremely high expression
Tissue   Expression Level
imaginal disc, larvae L3 wandering
 
 20
central nervous system, larvae L3
 
 17
central nervous system, pupae P8
 
 4
head, virgin 1-day female
 
 2
head, virgin 4-day female
 
 3
head, virgin 20-day female
 
 2
head, mated 1-day female
 
 2
head, mated 4-day female
 
 2
head, mated 20-day female
 
 2
head, mated 1-day male
 
 4
head, mated 4-day male
 
 3
head, mated 20-day male
 
 2
salivary gland, larvae L3 wandering
 
 0
salivary gland, white prepupae
 
 0
digestive system, larvae L3 wandering
 
 0
digestive system, 1-day adult
 
 1
digestive system, 4-day adult
 
 1
digestive system, 20-day adult
 
 1
fat body, larvae L3 wandering
 
 0
fat body, white prepupae
 
 2
fat body, pupae P8
 
 10
carcass, larvae L3 wandering
 
 10
carcass, 1-day adult
 
 2
carcass, 4-day adult
 
 1
carcass, 20-day adult
 
 2
ovary, virgin 4-day female
 
 0
ovary, mated 4-day female
 
 0
testis, mated 4-day male
 
 1
accessory gland, mated 4-day male
 
 2
Expression Level Scale
 Very low 
 Low 
 Moderate 
 Moderately high 
 High 
 Very high 
 Extremely high 
Heatmap
Tissue   Expression Level
imaginal disc, larvae L3 wandering
 
 
central nervous system, larvae L3
 
 
central nervous system, pupae P8
 
 
head, virgin 1-day female
 
 
head, virgin 4-day female
 
 
head, virgin 20-day female
 
 
head, mated 1-day female
 
 
head, mated 4-day female
 
 
head, mated 20-day female
 
 
head, mated 1-day male
 
 
head, mated 4-day male
 
 
head, mated 20-day male
 
 
salivary gland, larvae L3 wandering
 
 
salivary gland, white prepupae
 
 
digestive system, larvae L3 wandering
 
 
digestive system, 1-day adult
 
 
digestive system, 4-day adult
 
 
digestive system, 20-day adult
 
 
fat body, larvae L3 wandering
 
 
fat body, white prepupae
 
 
fat body, pupae P8
 
 
carcass, larvae L3 wandering
 
 
carcass, 1-day adult
 
 
carcass, 4-day adult
 
 
carcass, 20-day adult
 
 
ovary, virgin 4-day female
 
 
ovary, mated 4-day female
 
 
testis, mated 4-day male
 
 
accessory gland, mated 4-day male
 
 

hide modENCODE Development RNA-Seq

modENCODE Temporal Expression Data

(modENCODE_mRNA-Seq_U)


   Styles
   Scales

Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of very low expression. Peak expression observed within 06-18 hour embryonic stages, at stages throughout the pupal period.
[download data (TSV)]

Guide to modENCODE expression level colors
 
No/Extremely low expression (0 - 0)
 
Very low expression (1 - 3)
 
Low expression (4 - 10)
 
Moderate expression (11 - 25)
 
Moderately high expression (26 - 50)
 
High expression (51 - 100)
 
Very high expression (101 - 1000)
 
Extremely high expression (>1000)

Linear, scaled to maximum expression level
Developmental Stage   Expression Level
embryo 00-02hr
 
 1
embryo 02-04hr
 
 1
embryo 04-06hr
 
 1
embryo 06-08hr
 
 6
embryo 08-10hr
 
 13
embryo 10-12hr
 
 26
embryo 12-14hr
 
 25
embryo 14-16hr
 
 36
embryo 16-18hr
 
 17
embryo 18-20hr
 
 15
embryo 20-22hr
 
 8
embryo 22-24hr
 
 7
larva L1
 
 5
larva L2
 
 3
larva L3 12hr old
 
 2
larva L3 puffstage 1-2
 
 3
larva L3 puffstage 3-6
 
 6
larva L3 puffstage 7-9
 
 7
white prepupae new
 
 8
white prepupae 12hr
 
 12
white prepupae 24hr
 
 19
pupae 2d postWPP
 
 20
pupae 3d postWPP
 
 5
pupae 4d postWPP
 
 11
adult male 01day
 
 2
adult male 05day
 
 2
adult male 30day
 
 2
adult female 01day
 
 2
adult female 05day
 
 1
adult female 30day
 
 1
Expression Level Scale
 Very low 
 Low 
 Moderate 
 Moderately high 
Linear, scaled to Moderate expression
Developmental Stage   Expression Level
embryo 00-02hr
 
 1
embryo 02-04hr
 
 1
embryo 04-06hr
 
 1
embryo 06-08hr
 
 6
embryo 08-10hr
 
 13
embryo 10-12hr
 26
embryo 12-14hr
 
 25
embryo 14-16hr
 (36)
embryo 16-18hr
 
 17
embryo 18-20hr
 
 15
embryo 20-22hr
 
 8
embryo 22-24hr
 
 7
larva L1
 
 5
larva L2
 
 3
larva L3 12hr old
 
 2
larva L3 puffstage 1-2
 
 3
larva L3 puffstage 3-6
 
 6
larva L3 puffstage 7-9
 
 7
white prepupae new
 
 8
white prepupae 12hr
 
 12
white prepupae 24hr
 
 19
pupae 2d postWPP
 
 20
pupae 3d postWPP
 
 5
pupae 4d postWPP
 
 11
adult male 01day
 
 2
adult male 05day
 
 2
adult male 30day
 
 2
adult female 01day
 
 2
adult female 05day
 
 1
adult female 30day
 
 1
Expression Level Scale
 Very low 
 Low 
 Moderate 
 Moderately high 
Linear, scaled to High expression
Developmental Stage   Expression Level
embryo 00-02hr
 
 1
embryo 02-04hr
 
 1
embryo 04-06hr
 
 1
embryo 06-08hr
 
 6
embryo 08-10hr
 
 13
embryo 10-12hr
 
 26
embryo 12-14hr
 
 25
embryo 14-16hr
 
 36
embryo 16-18hr
 
 17
embryo 18-20hr
 
 15
embryo 20-22hr
 
 8
embryo 22-24hr
 
 7
larva L1
 
 5
larva L2
 
 3
larva L3 12hr old
 
 2
larva L3 puffstage 1-2
 
 3
larva L3 puffstage 3-6
 
 6
larva L3 puffstage 7-9
 
 7
white prepupae new
 
 8
white prepupae 12hr
 
 12
white prepupae 24hr
 
 19
pupae 2d postWPP
 
 20
pupae 3d postWPP
 
 5
pupae 4d postWPP
 
 11
adult male 01day
 
 2
adult male 05day
 
 2
adult male 30day
 
 2
adult female 01day
 
 2
adult female 05day
 
 1
adult female 30day
 
 1
Expression Level Scale
 Very low 
 Low 
 Moderate 
 Moderately high 
 High 
 Very high 
Linear, scaled to Extremely high expression
Developmental Stage   Expression Level
embryo 00-02hr
 
 1
embryo 02-04hr
 
 1
embryo 04-06hr
 
 1
embryo 06-08hr
 
 6
embryo 08-10hr
 
 13
embryo 10-12hr
 
 26
embryo 12-14hr
 
 25
embryo 14-16hr
 
 36
embryo 16-18hr
 
 17
embryo 18-20hr
 
 15
embryo 20-22hr
 
 8
embryo 22-24hr
 
 7
larva L1
 
 5
larva L2
 
 3
larva L3 12hr old
 
 2
larva L3 puffstage 1-2
 
 3
larva L3 puffstage 3-6
 
 6
larva L3 puffstage 7-9
 
 7
white prepupae new
 
 8
white prepupae 12hr
 
 12
white prepupae 24hr
 
 19
pupae 2d postWPP
 
 20
pupae 3d postWPP
 
 5
pupae 4d postWPP
 
 11
adult male 01day
 
 2
adult male 05day
 
 2
adult male 30day
 
 2
adult female 01day
 
 2
adult female 05day
 
 1
adult female 30day
 
 1
Expression Level Scale
 Extremely high 
log, scaled to maximum expression level
Developmental Stage   Expression Level
embryo 00-02hr
 
 1
embryo 02-04hr
 
 1
embryo 04-06hr
 
 1
embryo 06-08hr
 
 6
embryo 08-10hr
 
 13
embryo 10-12hr
 
 26
embryo 12-14hr
 
 25
embryo 14-16hr
 
 36
embryo 16-18hr
 
 17
embryo 18-20hr
 
 15
embryo 20-22hr
 
 8
embryo 22-24hr
 
 7
larva L1
 
 5
larva L2
 
 3
larva L3 12hr old
 
 2
larva L3 puffstage 1-2
 
 3
larva L3 puffstage 3-6
 
 6
larva L3 puffstage 7-9
 
 7
white prepupae new
 
 8
white prepupae 12hr
 
 12
white prepupae 24hr
 
 19
pupae 2d postWPP
 
 20
pupae 3d postWPP
 
 5
pupae 4d postWPP
 
 11
adult male 01day
 
 2
adult male 05day
 
 2
adult male 30day
 
 2
adult female 01day
 
 2
adult female 05day
 
 1
adult female 30day
 
 1
Expression Level Scale
 Very low 
 Low 
 Moderate 
 Moderately high 
 High 
log, scaled to Moderate expression
Developmental Stage   Expression Level
embryo 00-02hr
 
 1
embryo 02-04hr
 
 1
embryo 04-06hr
 
 1
embryo 06-08hr
 
 6
embryo 08-10hr
 
 13
embryo 10-12hr
 26
embryo 12-14hr
 
 25
embryo 14-16hr
 (36)
embryo 16-18hr
 
 17
embryo 18-20hr
 
 15
embryo 20-22hr
 
 8
embryo 22-24hr
 
 7
larva L1
 
 5
larva L2
 
 3
larva L3 12hr old
 
 2
larva L3 puffstage 1-2
 
 3
larva L3 puffstage 3-6
 
 6
larva L3 puffstage 7-9
 
 7
white prepupae new
 
 8
white prepupae 12hr
 
 12
white prepupae 24hr
 
 19
pupae 2d postWPP
 
 20
pupae 3d postWPP
 
 5
pupae 4d postWPP
 
 11
adult male 01day
 
 2
adult male 05day
 
 2
adult male 30day
 
 2
adult female 01day
 
 2
adult female 05day
 
 1
adult female 30day
 
 1
Expression Level Scale
 Very low 
 Low 
 Moderate 
 Moderately high 
log, scaled to High expression
Developmental Stage   Expression Level
embryo 00-02hr
 
 1
embryo 02-04hr
 
 1
embryo 04-06hr
 
 1
embryo 06-08hr
 
 6
embryo 08-10hr
 
 13
embryo 10-12hr
 
 26
embryo 12-14hr
 
 25
embryo 14-16hr
 
 36
embryo 16-18hr
 
 17
embryo 18-20hr
 
 15
embryo 20-22hr
 
 8
embryo 22-24hr
 
 7
larva L1
 
 5
larva L2
 
 3
larva L3 12hr old
 
 2
larva L3 puffstage 1-2
 
 3
larva L3 puffstage 3-6
 
 6
larva L3 puffstage 7-9
 
 7
white prepupae new
 
 8
white prepupae 12hr
 
 12
white prepupae 24hr
 
 19
pupae 2d postWPP
 
 20
pupae 3d postWPP
 
 5
pupae 4d postWPP
 
 11
adult male 01day
 
 2
adult male 05day
 
 2
adult male 30day
 
 2
adult female 01day
 
 2
adult female 05day
 
 1
adult female 30day
 
 1
Expression Level Scale
 Very low 
 Low 
 Moderate 
 Moderately high 
 High 
 Very high 
log, scaled to Extremely high expression
Developmental Stage   Expression Level
embryo 00-02hr
 
 1
embryo 02-04hr
 
 1
embryo 04-06hr
 
 1
embryo 06-08hr
 
 6
embryo 08-10hr
 
 13
embryo 10-12hr
 
 26
embryo 12-14hr
 
 25
embryo 14-16hr
 
 36
embryo 16-18hr
 
 17
embryo 18-20hr
 
 15
embryo 20-22hr
 
 8
embryo 22-24hr
 
 7
larva L1
 
 5
larva L2
 
 3
larva L3 12hr old
 
 2
larva L3 puffstage 1-2
 
 3
larva L3 puffstage 3-6
 
 6
larva L3 puffstage 7-9
 
 7
white prepupae new
 
 8
white prepupae 12hr
 
 12
white prepupae 24hr
 
 19
pupae 2d postWPP
 
 20
pupae 3d postWPP
 
 5
pupae 4d postWPP
 
 11
adult male 01day
 
 2
adult male 05day
 
 2
adult male 30day
 
 2
adult female 01day
 
 2
adult female 05day
 
 1
adult female 30day
 
 1
Expression Level Scale
 Very low 
 Low 
 Moderate 
 Moderately high 
 High 
 Very high 
 Extremely high 
Heatmap
Developmental Stage   Expression Level
embryo 00-02hr
 
 
embryo 02-04hr
 
 
embryo 04-06hr
 
 
embryo 06-08hr
 
 
embryo 08-10hr
 
 
embryo 10-12hr
 
 
embryo 12-14hr
 
 
embryo 14-16hr
 
 
embryo 16-18hr
 
 
embryo 18-20hr
 
 
embryo 20-22hr
 
 
embryo 22-24hr
 
 
larva L1
 
 
larva L2
 
 
larva L3 12hr old
 
 
larva L3 puffstage 1-2
 
 
larva L3 puffstage 3-6
 
 
larva L3 puffstage 7-9
 
 
white prepupae new
 
 
white prepupae 12hr
 
 
white prepupae 24hr
 
 
pupae 2d postWPP
 
 
pupae 3d postWPP
 
 
pupae 4d postWPP
 
 
adult male 01day
 
 
adult male 05day
 
 
adult male 30day
 
 
adult female 01day
 
 
adult female 05day
 
 
adult female 30day
 
 

modENCODE Temporal Expression Data (Graveley et al., 2011)
hide modENCODE Cell Lines RNA-Seq

modENCODE Cell Line Expression Data

(modENCODE_mRNA-Seq_cell.A)

(modENCODE_mRNA-Seq_cell.B)


   Styles
   Scales


[download data (TSV)]

Guide to modENCODE expression level colors
 
No/Extremely low expression (0 - 0)
 
Very low expression (1 - 3)
 
Low expression (4 - 10)
 
Moderate expression (11 - 25)
 
Moderately high expression (26 - 50)
 
High expression (51 - 100)
 
Very high expression (101 - 1000)
 
Extremely high expression (>1000)

Linear, scaled to maximum expression level
Cell Line   Expression Level
Schneider line 2 S2R+
 
 0
Schneider line 2 Sg4
 
 1
embryonic 1182-4H
 
 0
embryonic GM2
 
 0
embryonic Kc167
 
 0
embryonic S1
 
 0
embryonic S3
 
 0
leg disc CME L1
 
 0
wing disc CME-W2
 
 0
wing disc ML-DmD8
 
 2
wing disc ML-DmD9
 
 1
wing disc ML-DmD16-c3
 
 4
wing disc ML-DmD21
 
 1
wing disc ML-DmD32
 
 1
haltere disc ML-DmD17-c3
 
 5
eye-antennal disc ML-DmD11
 
 0
antennal disc ML-DmD20-c5
 
 1
mixed discs ML-DmD4-c1
 
 0
CNS ML-DmBG1-c1
 
 0
CNS ML-DmBG2-c2
 
 0
tumorous blood cells mbn2
 
 0
ovary fGS/OSS
 
 51
ovary OSC
 
 21
ovary OSS
 
 9
Expression Level Scale
 Very low 
 Low 
 Moderate 
 Moderately high 
 High 
Linear, scaled to Moderate expression
Cell Line   Expression Level
Schneider line 2 S2R+
 
 0
Schneider line 2 Sg4
 
 1
embryonic 1182-4H
 
 0
embryonic GM2
 
 0
embryonic Kc167
 
 0
embryonic S1
 
 0
embryonic S3
 
 0
leg disc CME L1
 
 0
wing disc CME-W2
 
 0
wing disc ML-DmD8
 
 2
wing disc ML-DmD9
 
 1
wing disc ML-DmD16-c3
 
 4
wing disc ML-DmD21
 
 1
wing disc ML-DmD32
 
 1
haltere disc ML-DmD17-c3
 
 5
eye-antennal disc ML-DmD11
 
 0
antennal disc ML-DmD20-c5
 
 1
mixed discs ML-DmD4-c1
 
 0
CNS ML-DmBG1-c1
 
 0
CNS ML-DmBG2-c2
 
 0
tumorous blood cells mbn2
 
 0
ovary fGS/OSS
 (51)
ovary OSC
 
 21
ovary OSS
 
 9
Expression Level Scale
 Very low 
 Low 
 Moderate 
 Moderately high 
Linear, scaled to High expression
Cell Line   Expression Level
Schneider line 2 S2R+
 
 0
Schneider line 2 Sg4
 
 1
embryonic 1182-4H
 
 0
embryonic GM2
 
 0
embryonic Kc167
 
 0
embryonic S1
 
 0
embryonic S3
 
 0
leg disc CME L1
 
 0
wing disc CME-W2
 
 0
wing disc ML-DmD8
 
 2
wing disc ML-DmD9
 
 1
wing disc ML-DmD16-c3
 
 4
wing disc ML-DmD21
 
 1
wing disc ML-DmD32
 
 1
haltere disc ML-DmD17-c3
 
 5
eye-antennal disc ML-DmD11
 
 0
antennal disc ML-DmD20-c5
 
 1
mixed discs ML-DmD4-c1
 
 0
CNS ML-DmBG1-c1
 
 0
CNS ML-DmBG2-c2
 
 0
tumorous blood cells mbn2
 
 0
ovary fGS/OSS
 
 51
ovary OSC
 
 21
ovary OSS
 
 9
Expression Level Scale
 Very low 
 Low 
 Moderate 
 Moderately high 
 High 
 Very high 
Linear, scaled to Extremely high expression
Cell Line   Expression Level
Schneider line 2 S2R+
 
 0
Schneider line 2 Sg4
 
 1
embryonic 1182-4H
 
 0
embryonic GM2
 
 0
embryonic Kc167
 
 0
embryonic S1
 
 0
embryonic S3
 
 0
leg disc CME L1
 
 0
wing disc CME-W2
 
 0
wing disc ML-DmD8
 
 2
wing disc ML-DmD9
 
 1
wing disc ML-DmD16-c3
 
 4
wing disc ML-DmD21
 
 1
wing disc ML-DmD32
 
 1
haltere disc ML-DmD17-c3
 
 5
eye-antennal disc ML-DmD11
 
 0
antennal disc ML-DmD20-c5
 
 1
mixed discs ML-DmD4-c1
 
 0
CNS ML-DmBG1-c1
 
 0
CNS ML-DmBG2-c2
 
 0
tumorous blood cells mbn2
 
 0
ovary fGS/OSS
 
 51
ovary OSC
 
 21
ovary OSS
 
 9
Expression Level Scale
 Extremely high 
log, scaled to maximum expression level
Cell Line   Expression Level
Schneider line 2 S2R+
 
 0
Schneider line 2 Sg4
 
 1
embryonic 1182-4H
 
 0
embryonic GM2
 
 0
embryonic Kc167
 
 0
embryonic S1
 
 0
embryonic S3
 
 0
leg disc CME L1
 
 0
wing disc CME-W2
 
 0
wing disc ML-DmD8
 
 2
wing disc ML-DmD9
 
 1
wing disc ML-DmD16-c3
 
 4
wing disc ML-DmD21
 
 1
wing disc ML-DmD32
 
 1
haltere disc ML-DmD17-c3
 
 5
eye-antennal disc ML-DmD11
 
 0
antennal disc ML-DmD20-c5
 
 1
mixed discs ML-DmD4-c1
 
 0
CNS ML-DmBG1-c1
 
 0
CNS ML-DmBG2-c2
 
 0
tumorous blood cells mbn2
 
 0
ovary fGS/OSS
 
 51
ovary OSC
 
 21
ovary OSS
 
 9
Expression Level Scale
 Very low 
 Low 
 Moderate 
 Moderately high 
 High 
log, scaled to Moderate expression
Cell Line   Expression Level
Schneider line 2 S2R+
 
 0
Schneider line 2 Sg4
 
 1
embryonic 1182-4H
 
 0
embryonic GM2
 
 0
embryonic Kc167
 
 0
embryonic S1
 
 0
embryonic S3
 
 0
leg disc CME L1
 
 0
wing disc CME-W2
 
 0
wing disc ML-DmD8
 
 2
wing disc ML-DmD9
 
 1
wing disc ML-DmD16-c3
 
 4
wing disc ML-DmD21
 
 1
wing disc ML-DmD32
 
 1
haltere disc ML-DmD17-c3
 
 5
eye-antennal disc ML-DmD11
 
 0
antennal disc ML-DmD20-c5
 
 1
mixed discs ML-DmD4-c1
 
 0
CNS ML-DmBG1-c1
 
 0
CNS ML-DmBG2-c2
 
 0
tumorous blood cells mbn2
 
 0
ovary fGS/OSS
 (51)
ovary OSC
 
 21
ovary OSS
 
 9
Expression Level Scale
 Very low 
 Low 
 Moderate 
 Moderately high 
log, scaled to High expression
Cell Line   Expression Level
Schneider line 2 S2R+
 
 0
Schneider line 2 Sg4
 
 1
embryonic 1182-4H
 
 0
embryonic GM2
 
 0
embryonic Kc167
 
 0
embryonic S1
 
 0
embryonic S3
 
 0
leg disc CME L1
 
 0
wing disc CME-W2
 
 0
wing disc ML-DmD8
 
 2
wing disc ML-DmD9
 
 1
wing disc ML-DmD16-c3
 
 4
wing disc ML-DmD21
 
 1
wing disc ML-DmD32
 
 1
haltere disc ML-DmD17-c3
 
 5
eye-antennal disc ML-DmD11
 
 0
antennal disc ML-DmD20-c5
 
 1
mixed discs ML-DmD4-c1
 
 0
CNS ML-DmBG1-c1
 
 0
CNS ML-DmBG2-c2
 
 0
tumorous blood cells mbn2
 
 0
ovary fGS/OSS
 
 51
ovary OSC
 
 21
ovary OSS
 
 9
Expression Level Scale
 Very low 
 Low 
 Moderate 
 Moderately high 
 High 
 Very high 
log, scaled to Extremely high expression
Cell Line   Expression Level
Schneider line 2 S2R+
 
 0
Schneider line 2 Sg4
 
 1
embryonic 1182-4H
 
 0
embryonic GM2
 
 0
embryonic Kc167
 
 0
embryonic S1
 
 0
embryonic S3
 
 0
leg disc CME L1
 
 0
wing disc CME-W2
 
 0
wing disc ML-DmD8
 
 2
wing disc ML-DmD9
 
 1
wing disc ML-DmD16-c3
 
 4
wing disc ML-DmD21
 
 1
wing disc ML-DmD32
 
 1
haltere disc ML-DmD17-c3
 
 5
eye-antennal disc ML-DmD11
 
 0
antennal disc ML-DmD20-c5
 
 1
mixed discs ML-DmD4-c1
 
 0
CNS ML-DmBG1-c1
 
 0
CNS ML-DmBG2-c2
 
 0
tumorous blood cells mbn2
 
 0
ovary fGS/OSS
 
 51
ovary OSC
 
 21
ovary OSS
 
 9
Expression Level Scale
 Very low 
 Low 
 Moderate 
 Moderately high 
 High 
 Very high 
 Extremely high 
Heatmap
Cell Line   Expression Level
Schneider line 2 S2R+
 
 
Schneider line 2 Sg4
 
 
embryonic 1182-4H
 
 
embryonic GM2
 
 
embryonic Kc167
 
 
embryonic S1
 
 
embryonic S3
 
 
leg disc CME L1
 
 
wing disc CME-W2
 
 
wing disc ML-DmD8
 
 
wing disc ML-DmD9
 
 
wing disc ML-DmD16-c3
 
 
wing disc ML-DmD21
 
 
wing disc ML-DmD32
 
 
haltere disc ML-DmD17-c3
 
 
eye-antennal disc ML-DmD11
 
 
antennal disc ML-DmD20-c5
 
 
mixed discs ML-DmD4-c1
 
 
CNS ML-DmBG1-c1
 
 
CNS ML-DmBG2-c2
 
 
tumorous blood cells mbn2
 
 
ovary fGS/OSS
 
 
ovary OSC
 
 
ovary OSS
 
 

hide modENCODE Treatments RNA-Seq

modENCODE Treatment Expression Data

(modENCODE_mRNA-Seq_treatments)


   Styles
   Scales


[download data (TSV)]

Guide to modENCODE expression level colors
 
No/Extremely low expression (0 - 0)
 
Very low expression (1 - 3)
 
Low expression (4 - 10)
 
Moderate expression (11 - 25)
 
Moderately high expression (26 - 50)
 
High expression (51 - 100)
 
Very high expression (101 - 1000)
 
Extremely high expression (>1000)

Linear, scaled to maximum expression level
Treatment   Expression Level
extended cold, 4-day adult
 
 4
cold shock, 4-day adult
 
 3
heat shock, 4-day adult
 
 1
Cadmium 50 mM 6 hrs, larvae L3
 
 1
Cadmium 50 mM 12 hrs, larvae L3
 
 1
Cadmium 50 mM 48 hrs, 4-day adult
 
 1
Cadmium 100 mM 48 hrs, 4-day adult
 
 1
Copper 0.5 mM 12 hrs, larvae L3
 
 4
Copper 15 mM 48 hrs, 4-day adult
 
 1
Zinc 5 mM 12 hrs, larvae L3
 
 3
Zinc 4.5 mM 48 hrs, 4-day adult
 
 1
Ethanol 2.5% 3 hrs, larvae L3
 
 1
Ethanol 5% 3 hrs, larvae L3
 
 1
Ethanol 10% 3 hrs, larvae L3
 
 1
Caffeine 1.5 mg/ml 4 hrs, larvae L3
 
 1
Caffeine 2.5 mg/ml 48 hrs, 4-day adult
 
 1
Caffeine 25 mg/ml 48 hrs, 4-day adult
 
 3
Paraquat 5 mM 48 hrs, 4-day adult
 
 1
Paraquat 10 mM 48 hrs, 4-day adult
 
 2
Rotenone 2 μg 12 hrs, larvae L3
 
 1
Rotenone 8 μg 12 hrs, larvae L3
 
 1
Expression Level Scale
 Very low 
 Low 
 Moderate 
Linear, scaled to Moderate expression
Treatment   Expression Level
extended cold, 4-day adult
 
 4
cold shock, 4-day adult
 
 3
heat shock, 4-day adult
 
 1
Cadmium 50 mM 6 hrs, larvae L3
 
 1
Cadmium 50 mM 12 hrs, larvae L3
 
 1
Cadmium 50 mM 48 hrs, 4-day adult
 
 1
Cadmium 100 mM 48 hrs, 4-day adult
 
 1
Copper 0.5 mM 12 hrs, larvae L3
 
 4
Copper 15 mM 48 hrs, 4-day adult
 
 1
Zinc 5 mM 12 hrs, larvae L3
 
 3
Zinc 4.5 mM 48 hrs, 4-day adult
 
 1
Ethanol 2.5% 3 hrs, larvae L3
 
 1
Ethanol 5% 3 hrs, larvae L3
 
 1
Ethanol 10% 3 hrs, larvae L3
 
 1
Caffeine 1.5 mg/ml 4 hrs, larvae L3
 
 1
Caffeine 2.5 mg/ml 48 hrs, 4-day adult
 
 1
Caffeine 25 mg/ml 48 hrs, 4-day adult
 
 3
Paraquat 5 mM 48 hrs, 4-day adult
 
 1
Paraquat 10 mM 48 hrs, 4-day adult
 
 2
Rotenone 2 μg 12 hrs, larvae L3
 
 1
Rotenone 8 μg 12 hrs, larvae L3
 
 1
Expression Level Scale
 Very low 
 Low 
 Moderate 
 Moderately high 
Linear, scaled to High expression
Treatment   Expression Level
extended cold, 4-day adult
 
 4
cold shock, 4-day adult
 
 3
heat shock, 4-day adult
 
 1
Cadmium 50 mM 6 hrs, larvae L3
 
 1
Cadmium 50 mM 12 hrs, larvae L3
 
 1
Cadmium 50 mM 48 hrs, 4-day adult
 
 1
Cadmium 100 mM 48 hrs, 4-day adult
 
 1
Copper 0.5 mM 12 hrs, larvae L3
 
 4
Copper 15 mM 48 hrs, 4-day adult
 
 1
Zinc 5 mM 12 hrs, larvae L3
 
 3
Zinc 4.5 mM 48 hrs, 4-day adult
 
 1
Ethanol 2.5% 3 hrs, larvae L3
 
 1
Ethanol 5% 3 hrs, larvae L3
 
 1
Ethanol 10% 3 hrs, larvae L3
 
 1
Caffeine 1.5 mg/ml 4 hrs, larvae L3
 
 1
Caffeine 2.5 mg/ml 48 hrs, 4-day adult
 
 1
Caffeine 25 mg/ml 48 hrs, 4-day adult
 
 3
Paraquat 5 mM 48 hrs, 4-day adult
 
 1
Paraquat 10 mM 48 hrs, 4-day adult
 
 2
Rotenone 2 μg 12 hrs, larvae L3
 
 1
Rotenone 8 μg 12 hrs, larvae L3
 
 1
Expression Level Scale
 Very low 
 Low 
 Moderate 
 Moderately high 
 High 
 Very high 
Linear, scaled to Extremely high expression
Treatment   Expression Level
extended cold, 4-day adult
 
 4
cold shock, 4-day adult
 
 3
heat shock, 4-day adult
 
 1
Cadmium 50 mM 6 hrs, larvae L3
 
 1
Cadmium 50 mM 12 hrs, larvae L3
 
 1
Cadmium 50 mM 48 hrs, 4-day adult
 
 1
Cadmium 100 mM 48 hrs, 4-day adult
 
 1
Copper 0.5 mM 12 hrs, larvae L3
 
 4
Copper 15 mM 48 hrs, 4-day adult
 
 1
Zinc 5 mM 12 hrs, larvae L3
 
 3
Zinc 4.5 mM 48 hrs, 4-day adult
 
 1
Ethanol 2.5% 3 hrs, larvae L3
 
 1
Ethanol 5% 3 hrs, larvae L3
 
 1
Ethanol 10% 3 hrs, larvae L3
 
 1
Caffeine 1.5 mg/ml 4 hrs, larvae L3
 
 1
Caffeine 2.5 mg/ml 48 hrs, 4-day adult
 
 1
Caffeine 25 mg/ml 48 hrs, 4-day adult
 
 3
Paraquat 5 mM 48 hrs, 4-day adult
 
 1
Paraquat 10 mM 48 hrs, 4-day adult
 
 2
Rotenone 2 μg 12 hrs, larvae L3
 
 1
Rotenone 8 μg 12 hrs, larvae L3
 
 1
Expression Level Scale
 Extremely high 
log, scaled to maximum expression level
Treatment   Expression Level
extended cold, 4-day adult
 
 4
cold shock, 4-day adult
 
 3
heat shock, 4-day adult
 
 1
Cadmium 50 mM 6 hrs, larvae L3
 
 1
Cadmium 50 mM 12 hrs, larvae L3
 
 1
Cadmium 50 mM 48 hrs, 4-day adult
 
 1
Cadmium 100 mM 48 hrs, 4-day adult
 
 1
Copper 0.5 mM 12 hrs, larvae L3
 
 4
Copper 15 mM 48 hrs, 4-day adult
 
 1
Zinc 5 mM 12 hrs, larvae L3
 
 3
Zinc 4.5 mM 48 hrs, 4-day adult
 
 1
Ethanol 2.5% 3 hrs, larvae L3
 
 1
Ethanol 5% 3 hrs, larvae L3
 
 1
Ethanol 10% 3 hrs, larvae L3
 
 1
Caffeine 1.5 mg/ml 4 hrs, larvae L3
 
 1
Caffeine 2.5 mg/ml 48 hrs, 4-day adult
 
 1
Caffeine 25 mg/ml 48 hrs, 4-day adult
 
 3
Paraquat 5 mM 48 hrs, 4-day adult
 
 1
Paraquat 10 mM 48 hrs, 4-day adult
 
 2
Rotenone 2 μg 12 hrs, larvae L3
 
 1
Rotenone 8 μg 12 hrs, larvae L3
 
 1
Expression Level Scale
 Very low 
 Low 
 Moderate 
log, scaled to Moderate expression
Treatment   Expression Level
extended cold, 4-day adult
 
 4
cold shock, 4-day adult
 
 3
heat shock, 4-day adult
 
 1
Cadmium 50 mM 6 hrs, larvae L3
 
 1
Cadmium 50 mM 12 hrs, larvae L3
 
 1
Cadmium 50 mM 48 hrs, 4-day adult
 
 1
Cadmium 100 mM 48 hrs, 4-day adult
 
 1
Copper 0.5 mM 12 hrs, larvae L3
 
 4
Copper 15 mM 48 hrs, 4-day adult
 
 1
Zinc 5 mM 12 hrs, larvae L3
 
 3
Zinc 4.5 mM 48 hrs, 4-day adult
 
 1
Ethanol 2.5% 3 hrs, larvae L3
 
 1
Ethanol 5% 3 hrs, larvae L3
 
 1
Ethanol 10% 3 hrs, larvae L3
 
 1
Caffeine 1.5 mg/ml 4 hrs, larvae L3
 
 1
Caffeine 2.5 mg/ml 48 hrs, 4-day adult
 
 1
Caffeine 25 mg/ml 48 hrs, 4-day adult
 
 3
Paraquat 5 mM 48 hrs, 4-day adult
 
 1
Paraquat 10 mM 48 hrs, 4-day adult
 
 2
Rotenone 2 μg 12 hrs, larvae L3
 
 1
Rotenone 8 μg 12 hrs, larvae L3
 
 1
Expression Level Scale
 Very low 
 Low 
 Moderate 
 Moderately high 
log, scaled to High expression
Treatment   Expression Level
extended cold, 4-day adult
 
 4
cold shock, 4-day adult
 
 3
heat shock, 4-day adult
 
 1
Cadmium 50 mM 6 hrs, larvae L3
 
 1
Cadmium 50 mM 12 hrs, larvae L3
 
 1
Cadmium 50 mM 48 hrs, 4-day adult
 
 1
Cadmium 100 mM 48 hrs, 4-day adult
 
 1
Copper 0.5 mM 12 hrs, larvae L3
 
 4
Copper 15 mM 48 hrs, 4-day adult
 
 1
Zinc 5 mM 12 hrs, larvae L3
 
 3
Zinc 4.5 mM 48 hrs, 4-day adult
 
 1
Ethanol 2.5% 3 hrs, larvae L3
 
 1
Ethanol 5% 3 hrs, larvae L3
 
 1
Ethanol 10% 3 hrs, larvae L3
 
 1
Caffeine 1.5 mg/ml 4 hrs, larvae L3
 
 1
Caffeine 2.5 mg/ml 48 hrs, 4-day adult
 
 1
Caffeine 25 mg/ml 48 hrs, 4-day adult
 
 3
Paraquat 5 mM 48 hrs, 4-day adult
 
 1
Paraquat 10 mM 48 hrs, 4-day adult
 
 2
Rotenone 2 μg 12 hrs, larvae L3
 
 1
Rotenone 8 μg 12 hrs, larvae L3
 
 1
Expression Level Scale
 Very low 
 Low 
 Moderate 
 Moderately high 
 High 
 Very high 
log, scaled to Extremely high expression
Treatment   Expression Level
extended cold, 4-day adult
 
 4
cold shock, 4-day adult
 
 3
heat shock, 4-day adult
 
 1
Cadmium 50 mM 6 hrs, larvae L3
 
 1
Cadmium 50 mM 12 hrs, larvae L3
 
 1
Cadmium 50 mM 48 hrs, 4-day adult
 
 1
Cadmium 100 mM 48 hrs, 4-day adult
 
 1
Copper 0.5 mM 12 hrs, larvae L3
 
 4
Copper 15 mM 48 hrs, 4-day adult
 
 1
Zinc 5 mM 12 hrs, larvae L3
 
 3
Zinc 4.5 mM 48 hrs, 4-day adult
 
 1
Ethanol 2.5% 3 hrs, larvae L3
 
 1
Ethanol 5% 3 hrs, larvae L3
 
 1
Ethanol 10% 3 hrs, larvae L3
 
 1
Caffeine 1.5 mg/ml 4 hrs, larvae L3
 
 1
Caffeine 2.5 mg/ml 48 hrs, 4-day adult
 
 1
Caffeine 25 mg/ml 48 hrs, 4-day adult
 
 3
Paraquat 5 mM 48 hrs, 4-day adult
 
 1
Paraquat 10 mM 48 hrs, 4-day adult
 
 2
Rotenone 2 μg 12 hrs, larvae L3
 
 1
Rotenone 8 μg 12 hrs, larvae L3
 
 1
Expression Level Scale
 Very low 
 Low 
 Moderate 
 Moderately high 
 High 
 Very high 
 Extremely high 
Heatmap
Treatment   Expression Level
extended cold, 4-day adult
 
 
cold shock, 4-day adult
 
 
heat shock, 4-day adult
 
 
Cadmium 50 mM 6 hrs, larvae L3
 
 
Cadmium 50 mM 12 hrs, larvae L3
 
 
Cadmium 50 mM 48 hrs, 4-day adult
 
 
Cadmium 100 mM 48 hrs, 4-day adult
 
 
Copper 0.5 mM 12 hrs, larvae L3
 
 
Copper 15 mM 48 hrs, 4-day adult
 
 
Zinc 5 mM 12 hrs, larvae L3
 
 
Zinc 4.5 mM 48 hrs, 4-day adult
 
 
Ethanol 2.5% 3 hrs, larvae L3
 
 
Ethanol 5% 3 hrs, larvae L3
 
 
Ethanol 10% 3 hrs, larvae L3
 
 
Caffeine 1.5 mg/ml 4 hrs, larvae L3
 
 
Caffeine 2.5 mg/ml 48 hrs, 4-day adult
 
 
Caffeine 25 mg/ml 48 hrs, 4-day adult
 
 
Paraquat 5 mM 48 hrs, 4-day adult
 
 
Paraquat 10 mM 48 hrs, 4-day adult
 
 
Rotenone 2 μg 12 hrs, larvae L3
 
 
Rotenone 8 μg 12 hrs, larvae L3
 
 

hide Expression Clusters
A cluster of genes with similar mRNA expression dynamics across development.
hide External Data & Images
Linkouts
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
hide Alleles & Phenotypes
hide Summary of Allele Phenotypes
Lethality
Allele
Sterility
Allele
Other Phenotypes
Allele
Phenotype manifest in
Allele
abdomen & macrochaeta
abdominal sternite & macrochaeta
abdominal tergite & macrochaeta
mesothoracic tergum & sensory mother cell & spindle
tarsal segment 1 & joint
tarsal segment 1 & joint, with Scer\GAL4C-765
tarsal segment 1 & joint, with Scer\GAL4da.G32
tarsal segment 3 & joint
tarsal segment 4 & joint
tarsal segment & joint
trichome & adult abdomen
trichome & adult abdomen | posterior compartment, with Scer\GAL4αTub84B.PL
trichome & adult abdomen | somatic clone | cell autonomous
trichome & adult abdomen | somatic clone | posterior compartment, with Scer\GAL4αTub84B.PL
trichome & costal cell
wing & cell
wing & pupa & cell, with Scer\GAL4en-e16E
wing hair & 1st posterior cell, with Scer\GAL4ptc-559.1
wing hair & cell & pupa, with Scer\GAL4en-e16E
hide Classical Alleles ( 92 )
For All Classical Alleles Show

Allele of pkClassMutagenStocksKnown lesion
pk1loss of function allele, hypomorphic allele - genetic evidence20 Yes
pkpk-sple-265 Yes
pksple-1amorphic allele - genetic evidence2 --
pkf070802 --
pksple-32 --
pkc06494a
1 --
pkc06494b
1 --
pkc07118
1 --
pkCB-0807-3
1 --
pkd013621 --
pkeqloss of function allele
1 --
pkEY229631 --
pkf041371 --
pkKG05718
1 --
pkMB11776
1 --
pkMI02868
1 --
pkNP2567
1 --
pkNP7324
1 --
pkpk-sple-131 Yes
pkpk-sple-221 Yes
pkpk-sple-61 --
pkSZ4amorphic allele - genetic evidence0 Yes
pk150 Yes
pk160 Yes
pk170 Yes
pk190 Yes
pk200 Yes
pk210 Yes
pk290 Yes
pk20 Yes
pk300 Yes
pk30 --
pk440 Yes
pk50 --
pk78a0 --
pk78b0 --
pk78d0 --
pk78f0 --
pk78g0 --
pk78l0 --
pk78m0 --
pk870 --
pkcn76k30 Yes
pkcn88e430 Yes
pkD1-rv10 --
pkD1-rv40 --
pkD1-rv50 --
pkD1-rv60 --
pkD1-rv70 --
pkD1-rv90 --
pkD10 --
pkDantimorphic allele - genetic evidence
0 --
pkDOr0 --
pkEP25570 Yes
pkGO12
0 --
pkJJ13
0 --
pkN4
0 --
pknap20 Yes
pkNpk0 --
pkpk-sple-100 --
pkpk-sple-110 --
pkpk-sple-120 --
pkpk-sple-140 Yes
pkpk-sple-180 --
pkpk-sple-230 Yes
pkpk-sple-250 --
pkpk-sple-280 --
pkpk-sple-320 --
pkpk-sple-330 --
pkpk-sple-340 --
pkpk-sple-350 Yes
pkpk-sple-370 Yes
pkpk-sple-380 --
pkpk-sple-390 --
pkpk-sple-400 Yes
pkpk-sple-410 --
pkpk-sple-430 --
pkpk-sple-460 Yes
pkpk-sple-470 Yes
pkpk-sple-480 Yes
pkpk-sple-490 Yes
pkpk-sple-70 --
pkpk-sple-80 --
pkpk-sple-90 --
pksple-270 --
pksple-20 --
pksple-360 --
pksple-420 --
pksple-40 --
pksple-50 --
pkTBJ21antimorphic allele - genetic evidence
0 --
pkunspecified
0 --
hide Alleles Carried on Transgenic Constructs ( 11 )
For All Alleles Carried on Transgenic Constructs Show

Allele of pkClassMutagenStocksKnown lesion
pkGD15101 Yes
pkHMS004081 Yes
pkKK1092941 Yes
pkScer\UAS.cGa1 Yes
pksple.Scer\UAS1 Yes
pkNIG.11084R0 Yes
pkpk.sev0 Yes
pksple.CtoA.sev0 Yes
pksple.sev0 Yes
pksple.ΔC1.sev0 --
pksple.ΔC2.sev0 --
hide Aneuploid Aberrations
Disrupted in
Not disrupted in
Partially disrupted in
hide Transgenic Constructs & Insertions
Transgenic Constructs
Type of construct
Name
Expression data
Insertions
Type of insertions
Name
Expression data
insertion of enhancer trap
insertion of enhancer trap binary system
insertion of mobile activating element
hide Gene Ontology: Function, Process & Cellular Component ( 12 unique terms )
hide Terms Based on Experimental Evidence ( 5 terms )
Molecular Function
CV term
References
inferred from physical interaction with UniProtKB:A1Z7N9
(assigned by UniProtKB)
Biological Process
CV term
References
Cellular Component ( 0 terms)
hide Terms Based on Predictions or Assertions ( 9 terms )
Molecular Function
CV term
References
Biological Process
CV term
References
traceable author statement
Cellular Component
CV term
References
traceable author statement
non-traceable author statement
hide Sequence Ontology: Class of Gene
hide Interactions & Pathways
hide Summary of Physical Interactions
hide Summary of Genetic Interactions
Interacts with
Please look at the allele data for full details of the genetic interactions
pk allele
Gene
References
hide External Data
Linkouts
BioGRID - A database of protein and genetic interactions
DroID - A comprehensive database of gene and protein interactions.
InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets.
hide Orthologs
hide OrthoDB Orthologs (85) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
Drosophila inclusive ortholog search
Dipteran inclusive ortholog search
Insect inclusive ortholog search
Arthropod inclusive ortholog search
Metazoa inclusive ortholog search
hideOrthologs in Drosophila Species (EOG66Q7C1)
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila melanogaster
fruit fly 
 
 
Drosophila sechellia
 
Y
 
Drosophila erecta
 
Y
 
Drosophila yakuba
 
Y
 
Drosophila pseudoobscura pseudoobscura
 
Y
 
Drosophila persimilis
 
Y
 
Drosophila willistoni
 
Y
 
Drosophila virilis
 
Y
 
Drosophila mojavensis
 
Y
 
Drosophila grimshawi
 
Y
 
hideOrthologs in non-Drosophila Dipterans (EOG6T1HVN)
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Aedes aegypti
Yellow fever mosquito 
Y
Anopheles gambiae
Malaria mosquito 
Y
Culex quinquefasciatus
Southern house mosquito 
Y
hideOrthologs in non-Dipteran Insects (EOG6FN3CQ)
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Apis mellifera
Western honey bee 
Amel\GB44796
Y
Nasonia vitripennis
Parasitic wasp 
Nvit\Nasvi2EG018205
Y
Acromyrmex echinatior
Panamanian leafcutter ant 
Aech\AECH12332
Y
Atta cephalotes
Leafcutter ant 
Acep\ACEP24901
Y
Camponotus floridanus
Florida carpenter ant 
Cflo\CFLO20372
Y
Harpegnathos saltator
Jerdons jumping ant 
Hsal\HSAL13029
Y
Linepithema humile
Argentine ant 
Lhum\LH21095
Y
Pogonomyrmex barbatus
Red harvester ant 
Pbar\PB25868
Y
Pogonomyrmex barbatus
Red harvester ant 
Pbar\PB25866
Y
Solenopsis invicta
Red fire ant 
Sinv\SINV10190
Y
Acyrthosiphon pisum
Pea aphid 
Y
Bombyx mori
Silkmoth 
Y
Pediculus humanus
Human body louse 
Y
Tribolium castaneum
Red flour beetle 
Y
hideOrthologs in non-Insect Arthropods (EOG6R4XHS)
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Daphnia pulex
Water flea 
Y
Ixodes scapularis
Deer tick 
Y
Ixodes scapularis
Deer tick 
Y
hideOrthologs in non-Arthropod Metazoa (EOG690M3S)
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Caenorhabditis elegans
Nematode 
Y
Caenorhabditis elegans
Nematode 
Y
Strongylocentrotus purpuratus
Purple sea urchin 
Y
Strongylocentrotus purpuratus
Purple sea urchin 
Y
Strongylocentrotus purpuratus
Purple sea urchin 
Y
Danio rerio
Zebrafish 
Y
Danio rerio
Zebrafish 
Y
Danio rerio
Zebrafish 
Y
Danio rerio
Zebrafish 
Y
Danio rerio
Zebrafish 
Y
Danio rerio
Zebrafish 
Y
Danio rerio
Zebrafish 
Y
Danio rerio
Zebrafish 
Y
Danio rerio
Zebrafish 
Y
Danio rerio
Zebrafish 
Y
Danio rerio
Zebrafish 
Y
Danio rerio
Zebrafish 
Y
Xenopus tropicalis
Western clawed frog 
Y
Xenopus tropicalis
Western clawed frog 
Y
Xenopus tropicalis
Western clawed frog 
Y
Xenopus tropicalis
Western clawed frog 
Y
Xenopus tropicalis
Western clawed frog 
Y
Xenopus tropicalis
Western clawed frog 
Y
Xenopus tropicalis
Western clawed frog 
Y
Xenopus tropicalis
Western clawed frog 
Y
Gallus gallus
Domestic chicken 
Y
Gallus gallus
Domestic chicken 
Y
Gallus gallus
Domestic chicken 
Y
Gallus gallus
Domestic chicken 
Y
Gallus gallus
Domestic chicken 
Y
Gallus gallus
Domestic chicken 
Y
Mus musculus
House mouse 
Y
Mus musculus
House mouse 
Y
Mus musculus
House mouse 
Y
Mus musculus
House mouse 
Y
Mus musculus
House mouse 
Y
Mus musculus
House mouse 
Y
Mus musculus
House mouse 
Y
Mus musculus
House mouse 
Y
Mus musculus
House mouse 
Y
Rattus norvegicus
Norway rat 
Y
Rattus norvegicus
Norway rat 
Y
Rattus norvegicus
Norway rat 
Y
Rattus norvegicus
Norway rat 
Y
Rattus norvegicus
Norway rat 
Y
Rattus norvegicus
Norway rat 
Y
Rattus norvegicus
Norway rat 
Y
Rattus norvegicus
Norway rat 
Y
Homo sapiens
Human 
Y
Homo sapiens
Human 
Y
Homo sapiens
Human 
Y
Homo sapiens
Human 
Y
Homo sapiens
Human 
Y
Homo sapiens
Human 
Y
Homo sapiens
Human 
Y
hide Human Orthologs (7)
Gene
OMIM
HGNC
 
 
 
 
 
 
 
 
hideAAA Orthologs (11) based on analysis using Dmel annotation version 4.3
Organism
Gene
Drosophila simulans
Drosophila sechellia
Drosophila erecta
Drosophila yakuba
Drosophila ananassae
Drosophila pseudoobscura pseudoobscura
Drosophila persimilis
Drosophila willistoni
Drosophila virilis
Drosophila mojavensis
Drosophila grimshawi
hide Stocks & Reagents
hide Stocks Listed in FlyBase ( 50 )
Bloomington
Harvard
Kyoto
105903
105875
VDRC
hide Genomic Clones ( 1 )
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
hide cDNA Clones ( 124 )
Please Note
This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones
Other clones
hide RNAi & Array Information
Linkouts
DRSC - Results from RNAi screens.
GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents
hide Antibody Information
hide Other Information
hide Discoverer
Ives, Nov. 1938.
 
hide Etymology
hide Identification
hide Relationship to Other Genes
Source for database identity of
Source for database merge of
Source for merge of: pk CG11084
Source for merge of: pk CG12830
Additional comments
Annotations CG12830 and CG11084 merged as CG11084 (which corresponds to pk) in release 3 of the genome annotation.
hide Other Comments
During development of the bristle lineage, Vang protein is localised in an anterior crescent in dividing sensillum precursor cells.
Mutations in fz-like class of genes fz, pk, Vang, stan and dsh act as strong enhancers of weak in or fy phenotypes.
in and fy are needed for cells to respond to pk and stan. Genetic analysis is not consistent with fz-like class of genes fz, pk, Vang, stan and dsh acting simply as positive or negative regulators of in and fy.
pk is required for a feedback loop that generates asymmetric planar cell polarity signalling in the wing.
The "Pk" class of alleles carry molecular lesions within the proximal 30kb of the transcription unit, whereas the "Pk-Sple" class of alleles map to the distal section of the transcription unit. In direction of increasing cytology: Spn43Aa+ pk+ Spn43Ab- nec- pk+ Ady43A-
Alleles can be divided into three phenotypic classes, "Pk", "Pk-Sple", and "Sple". No allele causes an embryonic phenotype, even when homozygous mutant embryos develop from homozygous mutant mothers. Deletions of the pk gene are fully viable and fertile. The defects of the double mutant "Pk-Sple" class are the same as those seen with deletions of the entire gene. Paradoxically the "Pk" and "Sple" classes give more severe phenotypes with "Pk" affecting the wing and notum and "Sple" in the legs abdomen and eyes.
The balance between the pk isoforms "Pk" and "Sple" is critical for the specification of planar polarity.
pk is a slightly haploinsufficient gene. A deficiency for pk (and some pk point mutants) shows a weak, partially penetrant dominant tissue polarity phenotype. This effect is enhanced by several Vang alleles. Phenotypic data suggest that genetics of Vang and its interactions with pk are complex. Several, but not all, Vang alleles act as enhancers of the pk haploinsufficient tissue polarity phenotype, and the pkTBJ21 antimorphic phenotype. Mutations in pk can also act as suppressors of Vang dominant phenotypes.
Mutants do not exhibit defects in the denticle belt of hairs of the larvae.
In pk mutants the dorsal/ventral boundary in the eye is respected but the mechanism for ommatidial polarization is perturbed. A likely explanation for the observed phenotype is that the fates of dorsal and ventral cells within a cluster have been interchanged.
Mosaic analysis demonstrates pk function in either R3, R4 or R5 photoreceptor cell appears to be sufficient to drive an ommatidium in the right direction.
Polarity pattern of wing, haltere and notum altered. Triple row bristles on anterior wing slanted proximally instead of distally. On the notum, the posterior acrostichal bristles are whorled.
Trichomes near L2 vein arranged in counterclockwise whorl on right wing blade, in clockwise whorl on left blade; trichomes in anterior wing occasionally duplicated. Somatic clones of homozygous pk mutant cells have been generated. Not a vital locus.
"AQ254872; BDGP:EP(2)2557" was stated as revision.
 
hide External Crossreferences & Linkouts
Sequence Crossreferences
RefSeq (Transcripts)
RefSeq (Proteins)
Entrez Gene - A searchable database of RefSeq genes.
Other Crossreferences
InterPro domains - A database of protein families, domains, and functional sites
PET domain (IPR010442)
Linkouts
BioGRID - A database of protein and genetic interactions
DroID - A comprehensive database of gene and protein interactions.
DRSC - Results from RNAi screens.
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans
FlyReactome - A curated knowledgebase of Drosophila melanogaster pathways
GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents
Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets.
modMine - Data generated by the modENCODE project.
hide Synonyms & Secondary IDs ( 14 )
Reported As
Symbol Synonym
Pk-Sple
Name Synonym
prickle-spiny legs
spiny legs
 
Secondary FlyBase IDs
  • FBgn0003477
  • FBgn0033151
  • FBgn0040783
hide References ( 228 )
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hide Recent research papers ( 19 )
Belalcazar et al., 2013, G3 (Bethesda) 3(1): 5--8
Insect wing membrane topography is determined by the dorsal wing epithelium. [FBrf0220472]
Warrington et al., 2013, Development 140(5): 1045--1054
The Frizzled-dependent planar polarity pathway locally promotes E-cadherin turnover via recruitment of RhoGEF2. [FBrf0220829]
Butchar et al., 2012, Genetics 191(4): 1213--1226
New negative feedback regulators of egfr signaling in Drosophila. [FBrf0219175]
Daulat et al., 2012, Mol. Cell. Biol. 32(1): 173--185
Mink1 Regulates β-Catenin-Independent Wnt Signaling via Prickle Phosphorylation. [FBrf0216890]
Kuroda et al., 2012, Mech. Dev. 128(11-12): 625--639
Canonical Wnt signaling in the visceral muscle is required for left-right asymmetric development of the Drosophila midgut. [FBrf0217619]
Peng et al., 2012, Dev. Cell 23(3): 507--518
Planar Polarized Protrusions Break the Symmetry of EGFR Signaling during Drosophila Bract Cell Fate Induction. [FBrf0219458]
Sagner et al., 2012, Curr. Biol. 22(14): 1296--1301
Establishment of Global Patterns of Planar Polarity during Growth of the Drosophila Wing Epithelium. [FBrf0219045]
Struhl et al., 2012, Development 139(19): 3665--3674
Dissecting the molecular bridges that mediate the function of Frizzled in planar cell polarity. [FBrf0220280]
Weber et al., 2012, Genetics 191(1): 145--162
Novel regulators of planar cell polarity: a genetic analysis in Drosophila. [FBrf0218210]
Weber et al., 2012, PLoS ONE 7(4): e34745
Genome-Wide Association Analysis of Oxidative Stress Resistance in Drosophila melanogaster. [FBrf0218073]
Hogan et al., 2011, PLoS Genet. 7(2): e1001305
Two frizzled planar cell polarity signals in the Drosophila wing are differentially organized by the fat/dachsous pathway. [FBrf0213159]
Luo et al., 2011, Development 138(13): 2761--2771
Direct targets of the D. melanogaster DSXF protein and the evolution of sexual development. [FBrf0213878]
Matsubara et al., 2011, Genes Dev. 25(18): 1982--1996
The seven-pass transmembrane cadherin Flamingo controls dendritic self-avoidance via its binding to a LIM domain protein, Espinas, in Drosophila sensory neurons. [FBrf0215818]
Michaut et al., 2011, Dev. Growth Differ. 53(9): 982--993
Analyzing the function of a hox gene: An evolutionary approach. [FBrf0216990]
Mirkovic et al., 2011, Nat. Struct. Mol. Biol. 18(6): 665--672
Nemo kinase phosphorylates β-catenin to promote ommatidial rotation and connects core PCP factors to E-cadherin-β-catenin. [FBrf0213849]
Mrkusich et al., 2011, Dev. Biol. 358(1): 224--230
The core planar cell polarity gene prickle interacts with flamingo to promote sensory axon advance in the Drosophila embryo. [FBrf0215204]
Shimizu et al., 2011, J. Neurosci. 31(13): 4944--4954
The wnt5/planar cell polarity pathway regulates axonal development of the Drosophila mushroom body neuron. [FBrf0213382]
Strutt et al., 2011, Dev. Cell 20(4): 511--525
Dynamics of core planar polarity protein turnover and stable assembly into discrete membrane subdomains. [FBrf0214246]
Tao et al., 2011, Am. J. Hum. Genet. 88(2): 138--149
Mutations in prickle orthologs cause seizures in flies, mice, and humans. [FBrf0212997]
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All reviews listed in FlyBase were published before 2011