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Gene Dmel\pnr

General Information
Symbol	Dmel\pnr	Species	D. melanogaster
Name	pannier	Annotation symbol	CG3978
Feature type	protein_coding_gene	FlyBase ID	FBgn0003117
Gene Model Status	Current	Stock availability	20 publicly available
Also Known As	dGATAa, GATA
Genomic Location
Chromosome (arm)	3R	Recombination map	3-58
Cytogenetic map	89A13-89B1	Sequence location	3R:11,851,921..11,867,526 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene pannier is referred to in FlyBase by the symbol Dmel\pnr (CG3978, FBgn0003117). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: RNA polymerase II repressing transcription factor binding; protein binding; sequence-specific DNA binding; RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity; RNA polymerase II transcription factor binding; sequence-specific DNA binding RNA polymerase II transcription factor activity; protein heterodimerization activity. There is experimental evidence for 13 unique biological process terms, many of which group under: single-organism developmental process; cardiovascular system development; system development; biological regulation; pigment metabolic process; sensory organ development; system process; single-organism metabolic process; positive regulation of cellular biosynthetic process; embryonic pattern specification; regulation of cellular amide metabolic process; embryonic development via the syncytial blastoderm; cardiocyte differentiation; cell fate commitment; heart contraction; hematopoietic or lymphoid organ development. 64 alleles are reported. The phenotypes of these alleles are annotated with: organ system; organ system subdivision; adult segment; thoracic segment; late extended germ band embryo; portion of tissue; extended germ band embryo; embryonic pericardial cell; anterior vertical bristle; heart primordium; imaginal precursor; external compound sense organ. It has 4 annotated transcripts and 4 annotated polypeptides. Protein features are: Zinc finger, GATA-type; Zinc finger, NHR/GATA-type. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of very low expression. Peak expression observed within 00-12 hour embryonic stages. Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: adult spermathecae. Comments on Affy2 ProbeSet: ProbeSet 1634370_a_at completely aligns to an exonic region common to each of the 2 FlyBase-annotated transcript isoforms of pnr. Gene sequence location is 3R:11851921..11867526.
User Contributed Data
	Beta version, feedback welcome
External Summaries
Phenotypic Description from the Red Book (Lindsley & Zimm 1992)
Gene/Allele symbols may differ from current usage	pnr: pannier Homozygous lethal. Dorsal anterior of embryo open.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02	Controlled Vocabulary Terms chaeta development
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 89A13-89B1   Limits computationally determined from genome sequence between P{PZ}blp01618 and P{PZ}gish04895&P{EP}EP3171
Experimentally Determined Cytological Location
Cytogenetic map Notes References 89A-89B   (determined by in situ hybridisation)   (Lin et al., 1995) 89A-89A   (determined by in situ hybridisation)   (Winick et al., 1993)
Experimentally Determined Recombination Data
Location	3-58 (Tearle and Nusslein-Volhard, 1987) 3-58.05 (Heitzler et al., 1996)
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\pnr for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.47
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) pnr-RA FBtr0083221  NM_057337   2720   540 pnr-RB FBtr0083220  NM_169697   2786   488 pnr-RC FBtr0335426  NM_001275691   3600   537 pnr-RD FBtr0335427  NM_001275692   2282   488
Additional Transcript Data & Comments
Reported size (kB)	3.0 (northern blot) (Ramain et al., 1993) 2.9 (compiled cDNA) (Winick et al., 1993)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein pnr-PA   FBpp0082675   57.0   540   8.83     NP_476685   AAN13693 pnr-PB   FBpp0082674   51.7   488   9.15     NP_732102   AAF55264 pnr-PC   FBpp0307408   56.8   537   8.83     NP_001262620   AGB96000 pnr-PD   FBpp0307409   51.7   488   9.15     NP_001262621   AGB96001
Additional Polypeptide Data & Comments
Reported size (kDa)	540 (aa); 57 (kD) (Winick et al., 1993, Ramain et al., 1993)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Zinc finger, NHR/GATA-type (IPR013088) Zinc finger, GATA-type (IPR000679)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AE014297 AAF55264   AE014297 AAN13693   AC007726   AC007755   AE014297 AGB96000   AE014297 AGB96001   AI260207   AI531528   AI531753   AI543412   AW944253   AY095095 AAM11423   BI141875   BI358079   BI632221   BI632797   BI636877   BI637733   BI638710   BI641076   BT031157   BT053737   CO154068   CO154428   CO155165   CO155703   CO284093   CO292271   CO298454   CO301671   CO303425   CO306536   CO324510   CO327303   CO327735   CO332229   CO336258   CO338083   CO338970   CO341041   CZ486816   EC063335   EC063597   EC064199   EC066154   EC077084   EC079240   EC084505   EC211390   EC248974   EC252934   EC255759   EC255775   EC255914   EC260203   EC261903   EC265541   EC266849   EC267089   GH747768   GH748018   GH748447   GH748638   GH750588   GH751943   GH752058   GH753946   GH754244   GH754373   GH754540   GH754809   GH757809   GH761277   GH771216   GH771258   GH771498   GH772709   GH772850   GH776828   GH780925   GH781114   GH781951   GH784243   GH785928   GH786554   GH786912   GH787800   GH788339   GH788492   GH788834   GH789273   GH789683   GH789869   GH790457   GH790667   GH792258   GH792798   GH793699   GH794695   GH794874   GH795689   GH795998   GH798338   GH800171   GH802397   GH802836   GH804908   GH806712   GH810201   GH810348   GH812109   GH814522   GH815151   GH815584   GH817056   GH817805   GH818429   GH819721   GH820384   GH821061   GH822083   GH824164   GH824640   GH824962   GH825220   GH825420   GH825608   GH825733   GH826712   GH827022   GH828663   GH829580   GH830214   GH830753   GH830974   GH831597   GH832248   GH832405   GH832453   GH833596   GH836744   GH837052   GH837721   GH837812   GH838077   GH839018   GH839145   GH839271   GH840133   GH840759   GH841751   GH841782   GH842261   GH845710   GH847308   GH847991   GH848294   GH851548   GH851692   GH853343   GH854535   GH855221   GH855273   GH855937   GH856287   GH857224   GH858096   GH859685   GH863222   GH863356   GH863591   GH865029   GH865413   GH866468   GH867871   GH869092   GH869218   GH869326   GH874139   GH874286   GH877928   GH879039   GH879046   GH880598   GH881693   GH884693   GH885005   GH886673   GH887617   GH888583   GH890378   GH891767   GH892679   GH893721   GH897845   GH900039   GH900117   GH900542   GH902524   GH903643   GH905789   GH905992   GH911051   GH911413   GH913148   GH913439   GH914512   GH914827   GH916397   GH922745   GH923697   GH925383   GH925478   GH926414   GH926522   GH927608   GH927657   GH928347   GH929793   GH934216   GH935057   GH936782   GH936908   GH937366   S68793 AAB29874   S68795 AAB29874   S68798 AAB29874   S68802   S68803 AAB29876   S68909
UniProtKB/Swiss-Prot	P52168
UniProtKB/TrEMBL	Q9VEZ8 Q8T3J0
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References regulatory region FBsf0000435296 3R:11,853,826..11,854,626 evidence=Reporter construct (in vivo) (Liang et al., 2012, Halfon, 2012.6.19) regulatory region FBsf0000436248 3R:11,854,234..11,854,784 evidence=Reporter construct (in vivo) (Zeitlinger et al., 2007, Halfon, 2012.6.19) regulatory region FBsf0000436359 3R:11,854,549..11,855,214 evidence=Reporter construct (in vivo) (Liang et al., 2012, Halfon, 2012.6.19) regulatory region FBsf0000436575 3R:11,845,919..11,847,909 evidence=Reporter construct (in vivo) (Weiss et al., 2010, Halfon, 2012.6.19)
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage 4   organism | 30-60% egg length & dorsal   (Heitzler et al., 1996) Comment:35-60% egg length embryonic stage 4 -- 6   dorsal ectoderm anlage   (Fisher et al., 2012) Comment:anlage in statu nascendi embryonic stage 6 -- 9   amnioserosa   (Heitzler et al., 1996) embryonic stage 6 -- 17   epidermis | dorsal   (Heitzler et al., 1996) embryonic stage 7 -- 8   amnioserosa anlage   (Fisher et al., 2012) dorsal ectoderm   (Fisher et al., 2012) embryonic stage 9 -- 10   dorsal epidermis primordium   (Fisher et al., 2012) Comment:reported as dorsal epidermis anlage embryonic stage 11   cardiogenic mesoderm   (Klinedinst and Bodmer, 2003) dorsal ectoderm   (Klinedinst and Bodmer, 2003) embryonic stage 11 -- 12   dorsal epidermis primordium   (Fisher et al., 2012) embryonic stage 13   dorsal ectoderm | restricted of embryonic thoracic segment   (Calleja et al., 2000) dorsal ectoderm | restricted of embryonic abdominal segment | subset   (Calleja et al., 2000) Comment:not expressed in A8 or A10-11. embryonic stage 13 -- 16   embryonic dorsal epidermis   (Fisher et al., 2012) wandering third instar larval stage   wing disc | restricted   (Ramain et al., 1993) eye-antennal disc | restricted   (Ramain et al., 1993) northern blot Stage Tissue/Position (including subcellular localization) Reference embryonic stage 5   organism | 20-60% egg length   (Winick et al., 1993) Comment:late embryonic stage 5 embryonic stage 5 -- 15     (Winick et al., 1993) Comment:reference states 2-12 hr AEL embryonic stage 8   amnioserosa   (Winick et al., 1993) Comment:mid embryonic stage 8 proctodeum | anterior to   (Winick et al., 1993) Comment:early embryonic stage 8 embryonic stage 11   epidermis | restricted   (Winick et al., 1993) embryonic stage 13   posterior spiracle primordium   (Winick et al., 1993) embryonic stage 13 -- 15   epidermis | dorsal   (Winick et al., 1993)
Additional Descriptive Data
	After germband retraction, pnr transcript is expressed just below the amnioserosa, and adjacent and dorsal to the ectodermal expression domain of ara. (Calleja et al., 2000) In late third instar larvae, pnr transcript is detected in a restricted pattern in the thoracic region of the dorsal mesothoracic (wing) disc. pnr transcript levels are highest in the dorsal-most thoracic region, especially where the dorsocentral and scutellar bristles will arise, and decrease gradually over the thoracic epithelial region. pnr transcript is also detected in a restricted pattern in the dorsal-most edge of the eye-antennal disc, in the region where postvertical and anterior vertical bristles will arise. (Ramain et al., 1993) Northern blot analysis reveals that pnr is expressed at high levels in embryos 2-12 hours post-fertilization. Using whole mount embryo in situ hybridization, pnr transcript is detected as early as stage 5, in 5 stripes. At stage 5, which corresponds to cellularization, the pnr transcript is present at 20-60% egg length, in a region which will give rise to the dorsal ectoderm and the amnioserosa. Early in stage 8, pnr is expressed in the dorsal section of the embryo, in a region delineated by the cephalic furrow and the proctodeum. By mid-stage 8, during germband extension, pnr transcripts begin to concentrate in the dorsal ectoderm, but some transcripts are still detected in the amnioserosa. In stage 11 embryos, pnr expression is only seen in the epidermis dorsal to the tracheal pit. By stage 13, when germ band shortening is complete, pnr transcripts are still present in the dorsal epidermis, but additional signal is detected in the posterior spiracles. At dorsal closure at stage 15, pnr is expressed in a single cell layer on either side of the midline, and in an anterior cluster of epidermal cells. (Winick et al., 1993) At stage 4 of embryogenesis, pnr transcript is detected dorsally at 35-60% of egg length, in cells which will give rise to the amnioserosa and the dorsal ectoderm. pnr is expressed in the amnioserosa until stage 9 of embryogenesis, and expression in the dorsal epidermis continues through dorsal closure. (Heitzler et al., 1996)
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
nucleus inferred from direct assay (Reim and Frasch, 2005)
Expression Deduced from Reporters
Reporter: P{GawB}pnrMD237 Stage Tissue/Position (including subcellular localization) Reference third instar larval stage   wing disc | restricted   (Calleja et al., 1996) salivary gland   (Giagtzoglou et al., 2005) wing disc | proximal   (Giagtzoglou et al., 2005) haltere disc | proximal   (Calleja et al., 2000) pupal stage & adult stage   thorax | dorsal   (Calleja et al., 1996) head | dorsal   (Calleja et al., 1996) abdomen | dorsal   (Calleja et al., 1996) cuticle | dorsal   (Calleja et al., 1996)
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: adult spermathecae. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    2.875 Larval Midgut    2.2 Larval Hindgut    5.7 Larval Malpighian Tubules    45 Larval Fat Body    36.1 Larval Salivary Gland    1 Larval Trachea    25.75 Larval Carcass    67.15 Adult Head    21.6 Adult Eye    5.7 Adult Brain    7.5 Adult Thoracic-Abdominal Ganglion    4.7 Adult Crop    6.4 Adult Midgut    21.6 Adult Hindgut    3.8 Adult Malpighian Tubules    2.3 Adult Fat Body    11 Adult Salivary Gland    7.7 Adult Heart    87.425 Adult VirginFemale Spermatheca    594.1 Adult InseminatedFemale Spermatheca    696.6 Adult Ovary    0.8 Adult Testis    4.1 Adult Male Accessory Gland    3.9 Adult Carcass    28 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    2.875 Larval Midgut    2.2 Larval Hindgut    5.7 Larval Malpighian Tubules    45 Larval Fat Body    36.1 Larval Salivary Gland    1 Larval Trachea    25.75 Larval Carcass    67.15 Adult Head    21.6 Adult Eye    5.7 Adult Brain    7.5 Adult Thoracic-Abdominal Ganglion    4.7 Adult Crop    6.4 Adult Midgut    21.6 Adult Hindgut    3.8 Adult Malpighian Tubules    2.3 Adult Fat Body    11 Adult Salivary Gland    7.7 Adult Heart    87.425 Adult VirginFemale Spermatheca  (594.1) Adult InseminatedFemale Spermatheca  (696.6) Adult Ovary    0.8 Adult Testis    4.1 Adult Male Accessory Gland    3.9 Adult Carcass    28 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    2.875 Larval Midgut    2.2 Larval Hindgut    5.7 Larval Malpighian Tubules    45 Larval Fat Body    36.1 Larval Salivary Gland    1 Larval Trachea    25.75 Larval Carcass    67.15 Adult Head    21.6 Adult Eye    5.7 Adult Brain    7.5 Adult Thoracic-Abdominal Ganglion    4.7 Adult Crop    6.4 Adult Midgut    21.6 Adult Hindgut    3.8 Adult Malpighian Tubules    2.3 Adult Fat Body    11 Adult Salivary Gland    7.7 Adult Heart    87.425 Adult VirginFemale Spermatheca    594.1 Adult InseminatedFemale Spermatheca    696.6 Adult Ovary    0.8 Adult Testis    4.1 Adult Male Accessory Gland    3.9 Adult Carcass    28 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    2.875 Larval Midgut    2.2 Larval Hindgut    5.7 Larval Malpighian Tubules    45 Larval Fat Body    36.1 Larval Salivary Gland    1 Larval Trachea    25.75 Larval Carcass    67.15 Adult Head    21.6 Adult Eye    5.7 Adult Brain    7.5 Adult Thoracic-Abdominal Ganglion    4.7 Adult Crop    6.4 Adult Midgut    21.6 Adult Hindgut    3.8 Adult Malpighian Tubules    2.3 Adult Fat Body    11 Adult Salivary Gland    7.7 Adult Heart    87.425 Adult VirginFemale Spermatheca    594.1 Adult InseminatedFemale Spermatheca    696.6 Adult Ovary    0.8 Adult Testis    4.1 Adult Male Accessory Gland    3.9 Adult Carcass    28 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    2.875 Larval Midgut    2.2 Larval Hindgut    5.7 Larval Malpighian Tubules    45 Larval Fat Body    36.1 Larval Salivary Gland    1 Larval Trachea    25.75 Larval Carcass    67.15 Adult Head    21.6 Adult Eye    5.7 Adult Brain    7.5 Adult Thoracic-Abdominal Ganglion    4.7 Adult Crop    6.4 Adult Midgut    21.6 Adult Hindgut    3.8 Adult Malpighian Tubules    2.3 Adult Fat Body    11 Adult Salivary Gland    7.7 Adult Heart    87.425 Adult VirginFemale Spermatheca    594.1 Adult InseminatedFemale Spermatheca    696.6 Adult Ovary    0.8 Adult Testis    4.1 Adult Male Accessory Gland    3.9 Adult Carcass    28 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    2.875 Larval Midgut    2.2 Larval Hindgut    5.7 Larval Malpighian Tubules    45 Larval Fat Body    36.1 Larval Salivary Gland    1 Larval Trachea    25.75 Larval Carcass    67.15 Adult Head    21.6 Adult Eye    5.7 Adult Brain    7.5 Adult Thoracic-Abdominal Ganglion    4.7 Adult Crop    6.4 Adult Midgut    21.6 Adult Hindgut    3.8 Adult Malpighian Tubules    2.3 Adult Fat Body    11 Adult Salivary Gland    7.7 Adult Heart    87.425 Adult VirginFemale Spermatheca  594.1 Adult InseminatedFemale Spermatheca  696.6 Adult Ovary    0.8 Adult Testis    4.1 Adult Male Accessory Gland    3.9 Adult Carcass    28 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    2.875 Larval Midgut    2.2 Larval Hindgut    5.7 Larval Malpighian Tubules    45 Larval Fat Body    36.1 Larval Salivary Gland    1 Larval Trachea    25.75 Larval Carcass    67.15 Adult Head    21.6 Adult Eye    5.7 Adult Brain    7.5 Adult Thoracic-Abdominal Ganglion    4.7 Adult Crop    6.4 Adult Midgut    21.6 Adult Hindgut    3.8 Adult Malpighian Tubules    2.3 Adult Fat Body    11 Adult Salivary Gland    7.7 Adult Heart    87.425 Adult VirginFemale Spermatheca    594.1 Adult InseminatedFemale Spermatheca    696.6 Adult Ovary    0.8 Adult Testis    4.1 Adult Male Accessory Gland    3.9 Adult Carcass    28 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    2.875 Larval Midgut    2.2 Larval Hindgut    5.7 Larval Malpighian Tubules    45 Larval Fat Body    36.1 Larval Salivary Gland    1 Larval Trachea    25.75 Larval Carcass    67.15 Adult Head    21.6 Adult Eye    5.7 Adult Brain    7.5 Adult Thoracic-Abdominal Ganglion    4.7 Adult Crop    6.4 Adult Midgut    21.6 Adult Hindgut    3.8 Adult Malpighian Tubules    2.3 Adult Fat Body    11 Adult Salivary Gland    7.7 Adult Heart    87.425 Adult VirginFemale Spermatheca    594.1 Adult InseminatedFemale Spermatheca    696.6 Adult Ovary    0.8 Adult Testis    4.1 Adult Male Accessory Gland    3.9 Adult Carcass    28 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    21.6   NA  Eye    5.7   NA  Brain    7.5   2.875  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    4.7   NA  Crop    6.4   2.2  Midgut    no informative data   5.7  Hindgut    3.8   45  Malpighian Tubules    2.3   36.1  Fat Body    no informative data   1  Salivary Gland    7.7   NA  Heart    87.425   25.75  Trachea    NA   NA  VirginFemale Spermatheca    594.1   NA  InseminatedFemale Spermatheca    696.6   NA  Ovary    0.8   NA  Testis    4.1   NA  Male Accessory Gland    3.9   67.15  Carcass    no informative data FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    5 central nervous system, larvae L3    2 central nervous system, pupae P8    0 head, virgin 1-day female    1 head, virgin 4-day female    1 head, virgin 20-day female    1 head, mated 1-day female    1 head, mated 4-day female    1 head, mated 20-day female    1 head, mated 1-day male    1 head, mated 4-day male    1 head, mated 20-day male    1 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    2 digestive system, larvae L3 wandering    1 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    3 fat body, pupae P8    4 carcass, larvae L3 wandering    5 carcass, 1-day adult    1 carcass, 4-day adult    1 carcass, 20-day adult    1 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    0 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    5 central nervous system, larvae L3    2 central nervous system, pupae P8    0 head, virgin 1-day female    1 head, virgin 4-day female    1 head, virgin 20-day female    1 head, mated 1-day female    1 head, mated 4-day female    1 head, mated 20-day female    1 head, mated 1-day male    1 head, mated 4-day male    1 head, mated 20-day male    1 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    2 digestive system, larvae L3 wandering    1 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    3 fat body, pupae P8    4 carcass, larvae L3 wandering    5 carcass, 1-day adult    1 carcass, 4-day adult    1 carcass, 20-day adult    1 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    0 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    5 central nervous system, larvae L3    2 central nervous system, pupae P8    0 head, virgin 1-day female    1 head, virgin 4-day female    1 head, virgin 20-day female    1 head, mated 1-day female    1 head, mated 4-day female    1 head, mated 20-day female    1 head, mated 1-day male    1 head, mated 4-day male    1 head, mated 20-day male    1 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    2 digestive system, larvae L3 wandering    1 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    3 fat body, pupae P8    4 carcass, larvae L3 wandering    5 carcass, 1-day adult    1 carcass, 4-day adult    1 carcass, 20-day adult    1 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    5 central nervous system, larvae L3    2 central nervous system, pupae P8    0 head, virgin 1-day female    1 head, virgin 4-day female    1 head, virgin 20-day female    1 head, mated 1-day female    1 head, mated 4-day female    1 head, mated 20-day female    1 head, mated 1-day male    1 head, mated 4-day male    1 head, mated 20-day male    1 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    2 digestive system, larvae L3 wandering    1 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    3 fat body, pupae P8    4 carcass, larvae L3 wandering    5 carcass, 1-day adult    1 carcass, 4-day adult    1 carcass, 20-day adult    1 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    0 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    5 central nervous system, larvae L3    2 central nervous system, pupae P8    0 head, virgin 1-day female    1 head, virgin 4-day female    1 head, virgin 20-day female    1 head, mated 1-day female    1 head, mated 4-day female    1 head, mated 20-day female    1 head, mated 1-day male    1 head, mated 4-day male    1 head, mated 20-day male    1 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    2 digestive system, larvae L3 wandering    1 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    3 fat body, pupae P8    4 carcass, larvae L3 wandering    5 carcass, 1-day adult    1 carcass, 4-day adult    1 carcass, 20-day adult    1 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    0 Expression Level Scale  Very low   Low   Moderate  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    5 central nervous system, larvae L3    2 central nervous system, pupae P8    0 head, virgin 1-day female    1 head, virgin 4-day female    1 head, virgin 20-day female    1 head, mated 1-day female    1 head, mated 4-day female    1 head, mated 20-day female    1 head, mated 1-day male    1 head, mated 4-day male    1 head, mated 20-day male    1 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    2 digestive system, larvae L3 wandering    1 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    3 fat body, pupae P8    4 carcass, larvae L3 wandering    5 carcass, 1-day adult    1 carcass, 4-day adult    1 carcass, 20-day adult    1 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    0 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    5 central nervous system, larvae L3    2 central nervous system, pupae P8    0 head, virgin 1-day female    1 head, virgin 4-day female    1 head, virgin 20-day female    1 head, mated 1-day female    1 head, mated 4-day female    1 head, mated 20-day female    1 head, mated 1-day male    1 head, mated 4-day male    1 head, mated 20-day male    1 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    2 digestive system, larvae L3 wandering    1 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    3 fat body, pupae P8    4 carcass, larvae L3 wandering    5 carcass, 1-day adult    1 carcass, 4-day adult    1 carcass, 20-day adult    1 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    5 central nervous system, larvae L3    2 central nervous system, pupae P8    0 head, virgin 1-day female    1 head, virgin 4-day female    1 head, virgin 20-day female    1 head, mated 1-day female    1 head, mated 4-day female    1 head, mated 20-day female    1 head, mated 1-day male    1 head, mated 4-day male    1 head, mated 20-day male    1 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    2 digestive system, larvae L3 wandering    1 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    3 fat body, pupae P8    4 carcass, larvae L3 wandering    5 carcass, 1-day adult    1 carcass, 4-day adult    1 carcass, 20-day adult    1 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of very low expression. Peak expression observed within 00-12 hour embryonic stages. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    1 embryo 02-04hr    12 embryo 04-06hr    34 embryo 06-08hr    31 embryo 08-10hr    23 embryo 10-12hr    15 embryo 12-14hr    8 embryo 14-16hr    5 embryo 16-18hr    3 embryo 18-20hr    4 embryo 20-22hr    3 embryo 22-24hr    2 larva L1    1 larva L2    1 larva L3 12hr old    1 larva L3 puffstage 1-2    1 larva L3 puffstage 3-6    3 larva L3 puffstage 7-9    4 white prepupae new    5 white prepupae 12hr    6 white prepupae 24hr    6 pupae 2d postWPP    2 pupae 3d postWPP    1 pupae 4d postWPP    1 adult male 01day    1 adult male 05day    1 adult male 30day    1 adult female 01day    1 adult female 05day    0 adult female 30day    0 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    1 embryo 02-04hr    12 embryo 04-06hr  (34) embryo 06-08hr  (31) embryo 08-10hr    23 embryo 10-12hr    15 embryo 12-14hr    8 embryo 14-16hr    5 embryo 16-18hr    3 embryo 18-20hr    4 embryo 20-22hr    3 embryo 22-24hr    2 larva L1    1 larva L2    1 larva L3 12hr old    1 larva L3 puffstage 1-2    1 larva L3 puffstage 3-6    3 larva L3 puffstage 7-9    4 white prepupae new    5 white prepupae 12hr    6 white prepupae 24hr    6 pupae 2d postWPP    2 pupae 3d postWPP    1 pupae 4d postWPP    1 adult male 01day    1 adult male 05day    1 adult male 30day    1 adult female 01day    1 adult female 05day    0 adult female 30day    0 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    1 embryo 02-04hr    12 embryo 04-06hr    34 embryo 06-08hr    31 embryo 08-10hr    23 embryo 10-12hr    15 embryo 12-14hr    8 embryo 14-16hr    5 embryo 16-18hr    3 embryo 18-20hr    4 embryo 20-22hr    3 embryo 22-24hr    2 larva L1    1 larva L2    1 larva L3 12hr old    1 larva L3 puffstage 1-2    1 larva L3 puffstage 3-6    3 larva L3 puffstage 7-9    4 white prepupae new    5 white prepupae 12hr    6 white prepupae 24hr    6 pupae 2d postWPP    2 pupae 3d postWPP    1 pupae 4d postWPP    1 adult male 01day    1 adult male 05day    1 adult male 30day    1 adult female 01day    1 adult female 05day    0 adult female 30day    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    1 embryo 02-04hr    12 embryo 04-06hr    34 embryo 06-08hr    31 embryo 08-10hr    23 embryo 10-12hr    15 embryo 12-14hr    8 embryo 14-16hr    5 embryo 16-18hr    3 embryo 18-20hr    4 embryo 20-22hr    3 embryo 22-24hr    2 larva L1    1 larva L2    1 larva L3 12hr old    1 larva L3 puffstage 1-2    1 larva L3 puffstage 3-6    3 larva L3 puffstage 7-9    4 white prepupae new    5 white prepupae 12hr    6 white prepupae 24hr    6 pupae 2d postWPP    2 pupae 3d postWPP    1 pupae 4d postWPP    1 adult male 01day    1 adult male 05day    1 adult male 30day    1 adult female 01day    1 adult female 05day    0 adult female 30day    0 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    1 embryo 02-04hr    12 embryo 04-06hr    34 embryo 06-08hr    31 embryo 08-10hr    23 embryo 10-12hr    15 embryo 12-14hr    8 embryo 14-16hr    5 embryo 16-18hr    3 embryo 18-20hr    4 embryo 20-22hr    3 embryo 22-24hr    2 larva L1    1 larva L2    1 larva L3 12hr old    1 larva L3 puffstage 1-2    1 larva L3 puffstage 3-6    3 larva L3 puffstage 7-9    4 white prepupae new    5 white prepupae 12hr    6 white prepupae 24hr    6 pupae 2d postWPP    2 pupae 3d postWPP    1 pupae 4d postWPP    1 adult male 01day    1 adult male 05day    1 adult male 30day    1 adult female 01day    1 adult female 05day    0 adult female 30day    0 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    1 embryo 02-04hr    12 embryo 04-06hr  (34) embryo 06-08hr  31 embryo 08-10hr    23 embryo 10-12hr    15 embryo 12-14hr    8 embryo 14-16hr    5 embryo 16-18hr    3 embryo 18-20hr    4 embryo 20-22hr    3 embryo 22-24hr    2 larva L1    1 larva L2    1 larva L3 12hr old    1 larva L3 puffstage 1-2    1 larva L3 puffstage 3-6    3 larva L3 puffstage 7-9    4 white prepupae new    5 white prepupae 12hr    6 white prepupae 24hr    6 pupae 2d postWPP    2 pupae 3d postWPP    1 pupae 4d postWPP    1 adult male 01day    1 adult male 05day    1 adult male 30day    1 adult female 01day    1 adult female 05day    0 adult female 30day    0 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    1 embryo 02-04hr    12 embryo 04-06hr    34 embryo 06-08hr    31 embryo 08-10hr    23 embryo 10-12hr    15 embryo 12-14hr    8 embryo 14-16hr    5 embryo 16-18hr    3 embryo 18-20hr    4 embryo 20-22hr    3 embryo 22-24hr    2 larva L1    1 larva L2    1 larva L3 12hr old    1 larva L3 puffstage 1-2    1 larva L3 puffstage 3-6    3 larva L3 puffstage 7-9    4 white prepupae new    5 white prepupae 12hr    6 white prepupae 24hr    6 pupae 2d postWPP    2 pupae 3d postWPP    1 pupae 4d postWPP    1 adult male 01day    1 adult male 05day    1 adult male 30day    1 adult female 01day    1 adult female 05day    0 adult female 30day    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    1 embryo 02-04hr    12 embryo 04-06hr    34 embryo 06-08hr    31 embryo 08-10hr    23 embryo 10-12hr    15 embryo 12-14hr    8 embryo 14-16hr    5 embryo 16-18hr    3 embryo 18-20hr    4 embryo 20-22hr    3 embryo 22-24hr    2 larva L1    1 larva L2    1 larva L3 12hr old    1 larva L3 puffstage 1-2    1 larva L3 puffstage 3-6    3 larva L3 puffstage 7-9    4 white prepupae new    5 white prepupae 12hr    6 white prepupae 24hr    6 pupae 2d postWPP    2 pupae 3d postWPP    1 pupae 4d postWPP    1 adult male 01day    1 adult male 05day    1 adult male 30day    1 adult female 01day    1 adult female 05day    0 adult female 30day    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    108 Schneider line 2 Sg4    0 embryonic 1182-4H    81 embryonic GM2    5 embryonic Kc167    0 embryonic S1    109 embryonic S3    0 leg disc CME L1    0 wing disc CME-W2    0 wing disc ML-DmD8    75 wing disc ML-DmD9    135 wing disc ML-DmD16-c3    122 wing disc ML-DmD21    0 wing disc ML-DmD32    118 haltere disc ML-DmD17-c3    2 eye-antennal disc ML-DmD11    95 antennal disc ML-DmD20-c5    65 mixed discs ML-DmD4-c1    81 CNS ML-DmBG1-c1    165 CNS ML-DmBG2-c2    36 tumorous blood cells mbn2    89 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (108) Schneider line 2 Sg4    0 embryonic 1182-4H  (81) embryonic GM2    5 embryonic Kc167    0 embryonic S1  (109) embryonic S3    0 leg disc CME L1    0 wing disc CME-W2    0 wing disc ML-DmD8  (75) wing disc ML-DmD9  (135) wing disc ML-DmD16-c3  (122) wing disc ML-DmD21    0 wing disc ML-DmD32  (118) haltere disc ML-DmD17-c3    2 eye-antennal disc ML-DmD11  (95) antennal disc ML-DmD20-c5  (65) mixed discs ML-DmD4-c1  (81) CNS ML-DmBG1-c1  (165) CNS ML-DmBG2-c2  (36) tumorous blood cells mbn2  (89) ovary fGS/OSS    0 ovary OSC    0 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+  (108) Schneider line 2 Sg4    0 embryonic 1182-4H    81 embryonic GM2    5 embryonic Kc167    0 embryonic S1  (109) embryonic S3    0 leg disc CME L1    0 wing disc CME-W2    0 wing disc ML-DmD8    75 wing disc ML-DmD9  (135) wing disc ML-DmD16-c3  (122) wing disc ML-DmD21    0 wing disc ML-DmD32  (118) haltere disc ML-DmD17-c3    2 eye-antennal disc ML-DmD11    95 antennal disc ML-DmD20-c5    65 mixed discs ML-DmD4-c1    81 CNS ML-DmBG1-c1  (165) CNS ML-DmBG2-c2    36 tumorous blood cells mbn2    89 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    108 Schneider line 2 Sg4    0 embryonic 1182-4H    81 embryonic GM2    5 embryonic Kc167    0 embryonic S1    109 embryonic S3    0 leg disc CME L1    0 wing disc CME-W2    0 wing disc ML-DmD8    75 wing disc ML-DmD9    135 wing disc ML-DmD16-c3    122 wing disc ML-DmD21    0 wing disc ML-DmD32    118 haltere disc ML-DmD17-c3    2 eye-antennal disc ML-DmD11    95 antennal disc ML-DmD20-c5    65 mixed discs ML-DmD4-c1    81 CNS ML-DmBG1-c1    165 CNS ML-DmBG2-c2    36 tumorous blood cells mbn2    89 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    0 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    108 Schneider line 2 Sg4    0 embryonic 1182-4H    81 embryonic GM2    5 embryonic Kc167    0 embryonic S1    109 embryonic S3    0 leg disc CME L1    0 wing disc CME-W2    0 wing disc ML-DmD8    75 wing disc ML-DmD9    135 wing disc ML-DmD16-c3    122 wing disc ML-DmD21    0 wing disc ML-DmD32    118 haltere disc ML-DmD17-c3    2 eye-antennal disc ML-DmD11    95 antennal disc ML-DmD20-c5    65 mixed discs ML-DmD4-c1    81 CNS ML-DmBG1-c1    165 CNS ML-DmBG2-c2    36 tumorous blood cells mbn2    89 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (108) Schneider line 2 Sg4    0 embryonic 1182-4H  (81) embryonic GM2    5 embryonic Kc167    0 embryonic S1  (109) embryonic S3    0 leg disc CME L1    0 wing disc CME-W2    0 wing disc ML-DmD8  (75) wing disc ML-DmD9  (135) wing disc ML-DmD16-c3  (122) wing disc ML-DmD21    0 wing disc ML-DmD32  (118) haltere disc ML-DmD17-c3    2 eye-antennal disc ML-DmD11  (95) antennal disc ML-DmD20-c5  (65) mixed discs ML-DmD4-c1  (81) CNS ML-DmBG1-c1  (165) CNS ML-DmBG2-c2  (36) tumorous blood cells mbn2  (89) ovary fGS/OSS    0 ovary OSC    0 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+  108 Schneider line 2 Sg4    0 embryonic 1182-4H    81 embryonic GM2    5 embryonic Kc167    0 embryonic S1  109 embryonic S3    0 leg disc CME L1    0 wing disc CME-W2    0 wing disc ML-DmD8    75 wing disc ML-DmD9  135 wing disc ML-DmD16-c3  122 wing disc ML-DmD21    0 wing disc ML-DmD32  118 haltere disc ML-DmD17-c3    2 eye-antennal disc ML-DmD11    95 antennal disc ML-DmD20-c5    65 mixed discs ML-DmD4-c1    81 CNS ML-DmBG1-c1  (165) CNS ML-DmBG2-c2    36 tumorous blood cells mbn2    89 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    108 Schneider line 2 Sg4    0 embryonic 1182-4H    81 embryonic GM2    5 embryonic Kc167    0 embryonic S1    109 embryonic S3    0 leg disc CME L1    0 wing disc CME-W2    0 wing disc ML-DmD8    75 wing disc ML-DmD9    135 wing disc ML-DmD16-c3    122 wing disc ML-DmD21    0 wing disc ML-DmD32    118 haltere disc ML-DmD17-c3    2 eye-antennal disc ML-DmD11    95 antennal disc ML-DmD20-c5    65 mixed discs ML-DmD4-c1    81 CNS ML-DmBG1-c1    165 CNS ML-DmBG2-c2    36 tumorous blood cells mbn2    89 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    2 cold shock, 4-day adult    3 heat shock, 4-day adult    1 Cadmium 50 mM 6 hrs, larvae L3    1 Cadmium 50 mM 12 hrs, larvae L3    2 Cadmium 50 mM 48 hrs, 4-day adult    0 Cadmium 100 mM 48 hrs, 4-day adult    0 Copper 0.5 mM 12 hrs, larvae L3    2 Copper 15 mM 48 hrs, 4-day adult    0 Zinc 5 mM 12 hrs, larvae L3    2 Zinc 4.5 mM 48 hrs, 4-day adult    1 Ethanol 2.5% 3 hrs, larvae L3    0 Ethanol 5% 3 hrs, larvae L3    1 Ethanol 10% 3 hrs, larvae L3    1 Caffeine 1.5 mg/ml 4 hrs, larvae L3    1 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    0 Caffeine 25 mg/ml 48 hrs, 4-day adult    3 Paraquat 5 mM 48 hrs, 4-day adult    1 Paraquat 10 mM 48 hrs, 4-day adult    1 Rotenone 2 μg 12 hrs, larvae L3    1 Rotenone 8 μg 12 hrs, larvae L3    1 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    2 cold shock, 4-day adult    3 heat shock, 4-day adult    1 Cadmium 50 mM 6 hrs, larvae L3    1 Cadmium 50 mM 12 hrs, larvae L3    2 Cadmium 50 mM 48 hrs, 4-day adult    0 Cadmium 100 mM 48 hrs, 4-day adult    0 Copper 0.5 mM 12 hrs, larvae L3    2 Copper 15 mM 48 hrs, 4-day adult    0 Zinc 5 mM 12 hrs, larvae L3    2 Zinc 4.5 mM 48 hrs, 4-day adult    1 Ethanol 2.5% 3 hrs, larvae L3    0 Ethanol 5% 3 hrs, larvae L3    1 Ethanol 10% 3 hrs, larvae L3    1 Caffeine 1.5 mg/ml 4 hrs, larvae L3    1 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    0 Caffeine 25 mg/ml 48 hrs, 4-day adult    3 Paraquat 5 mM 48 hrs, 4-day adult    1 Paraquat 10 mM 48 hrs, 4-day adult    1 Rotenone 2 μg 12 hrs, larvae L3    1 Rotenone 8 μg 12 hrs, larvae L3    1 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    2 cold shock, 4-day adult    3 heat shock, 4-day adult    1 Cadmium 50 mM 6 hrs, larvae L3    1 Cadmium 50 mM 12 hrs, larvae L3    2 Cadmium 50 mM 48 hrs, 4-day adult    0 Cadmium 100 mM 48 hrs, 4-day adult    0 Copper 0.5 mM 12 hrs, larvae L3    2 Copper 15 mM 48 hrs, 4-day adult    0 Zinc 5 mM 12 hrs, larvae L3    2 Zinc 4.5 mM 48 hrs, 4-day adult    1 Ethanol 2.5% 3 hrs, larvae L3    0 Ethanol 5% 3 hrs, larvae L3    1 Ethanol 10% 3 hrs, larvae L3    1 Caffeine 1.5 mg/ml 4 hrs, larvae L3    1 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    0 Caffeine 25 mg/ml 48 hrs, 4-day adult    3 Paraquat 5 mM 48 hrs, 4-day adult    1 Paraquat 10 mM 48 hrs, 4-day adult    1 Rotenone 2 μg 12 hrs, larvae L3    1 Rotenone 8 μg 12 hrs, larvae L3    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    2 cold shock, 4-day adult    3 heat shock, 4-day adult    1 Cadmium 50 mM 6 hrs, larvae L3    1 Cadmium 50 mM 12 hrs, larvae L3    2 Cadmium 50 mM 48 hrs, 4-day adult    0 Cadmium 100 mM 48 hrs, 4-day adult    0 Copper 0.5 mM 12 hrs, larvae L3    2 Copper 15 mM 48 hrs, 4-day adult    0 Zinc 5 mM 12 hrs, larvae L3    2 Zinc 4.5 mM 48 hrs, 4-day adult    1 Ethanol 2.5% 3 hrs, larvae L3    0 Ethanol 5% 3 hrs, larvae L3    1 Ethanol 10% 3 hrs, larvae L3    1 Caffeine 1.5 mg/ml 4 hrs, larvae L3    1 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    0 Caffeine 25 mg/ml 48 hrs, 4-day adult    3 Paraquat 5 mM 48 hrs, 4-day adult    1 Paraquat 10 mM 48 hrs, 4-day adult    1 Rotenone 2 μg 12 hrs, larvae L3    1 Rotenone 8 μg 12 hrs, larvae L3    1 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    2 cold shock, 4-day adult    3 heat shock, 4-day adult    1 Cadmium 50 mM 6 hrs, larvae L3    1 Cadmium 50 mM 12 hrs, larvae L3    2 Cadmium 50 mM 48 hrs, 4-day adult    0 Cadmium 100 mM 48 hrs, 4-day adult    0 Copper 0.5 mM 12 hrs, larvae L3    2 Copper 15 mM 48 hrs, 4-day adult    0 Zinc 5 mM 12 hrs, larvae L3    2 Zinc 4.5 mM 48 hrs, 4-day adult    1 Ethanol 2.5% 3 hrs, larvae L3    0 Ethanol 5% 3 hrs, larvae L3    1 Ethanol 10% 3 hrs, larvae L3    1 Caffeine 1.5 mg/ml 4 hrs, larvae L3    1 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    0 Caffeine 25 mg/ml 48 hrs, 4-day adult    3 Paraquat 5 mM 48 hrs, 4-day adult    1 Paraquat 10 mM 48 hrs, 4-day adult    1 Rotenone 2 μg 12 hrs, larvae L3    1 Rotenone 8 μg 12 hrs, larvae L3    1 Expression Level Scale  Very low   Low   Moderate  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    2 cold shock, 4-day adult    3 heat shock, 4-day adult    1 Cadmium 50 mM 6 hrs, larvae L3    1 Cadmium 50 mM 12 hrs, larvae L3    2 Cadmium 50 mM 48 hrs, 4-day adult    0 Cadmium 100 mM 48 hrs, 4-day adult    0 Copper 0.5 mM 12 hrs, larvae L3    2 Copper 15 mM 48 hrs, 4-day adult    0 Zinc 5 mM 12 hrs, larvae L3    2 Zinc 4.5 mM 48 hrs, 4-day adult    1 Ethanol 2.5% 3 hrs, larvae L3    0 Ethanol 5% 3 hrs, larvae L3    1 Ethanol 10% 3 hrs, larvae L3    1 Caffeine 1.5 mg/ml 4 hrs, larvae L3    1 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    0 Caffeine 25 mg/ml 48 hrs, 4-day adult    3 Paraquat 5 mM 48 hrs, 4-day adult    1 Paraquat 10 mM 48 hrs, 4-day adult    1 Rotenone 2 μg 12 hrs, larvae L3    1 Rotenone 8 μg 12 hrs, larvae L3    1 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    2 cold shock, 4-day adult    3 heat shock, 4-day adult    1 Cadmium 50 mM 6 hrs, larvae L3    1 Cadmium 50 mM 12 hrs, larvae L3    2 Cadmium 50 mM 48 hrs, 4-day adult    0 Cadmium 100 mM 48 hrs, 4-day adult    0 Copper 0.5 mM 12 hrs, larvae L3    2 Copper 15 mM 48 hrs, 4-day adult    0 Zinc 5 mM 12 hrs, larvae L3    2 Zinc 4.5 mM 48 hrs, 4-day adult    1 Ethanol 2.5% 3 hrs, larvae L3    0 Ethanol 5% 3 hrs, larvae L3    1 Ethanol 10% 3 hrs, larvae L3    1 Caffeine 1.5 mg/ml 4 hrs, larvae L3    1 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    0 Caffeine 25 mg/ml 48 hrs, 4-day adult    3 Paraquat 5 mM 48 hrs, 4-day adult    1 Paraquat 10 mM 48 hrs, 4-day adult    1 Rotenone 2 μg 12 hrs, larvae L3    1 Rotenone 8 μg 12 hrs, larvae L3    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    2 cold shock, 4-day adult    3 heat shock, 4-day adult    1 Cadmium 50 mM 6 hrs, larvae L3    1 Cadmium 50 mM 12 hrs, larvae L3    2 Cadmium 50 mM 48 hrs, 4-day adult    0 Cadmium 100 mM 48 hrs, 4-day adult    0 Copper 0.5 mM 12 hrs, larvae L3    2 Copper 15 mM 48 hrs, 4-day adult    0 Zinc 5 mM 12 hrs, larvae L3    2 Zinc 4.5 mM 48 hrs, 4-day adult    1 Ethanol 2.5% 3 hrs, larvae L3    0 Ethanol 5% 3 hrs, larvae L3    1 Ethanol 10% 3 hrs, larvae L3    1 Caffeine 1.5 mg/ml 4 hrs, larvae L3    1 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    0 Caffeine 25 mg/ml 48 hrs, 4-day adult    3 Paraquat 5 mM 48 hrs, 4-day adult    1 Paraquat 10 mM 48 hrs, 4-day adult    1 Rotenone 2 μg 12 hrs, larvae L3    1 Rotenone 8 μg 12 hrs, larvae L3    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010, Graveley et al., 2011) mE2_34_mRNA_expression_cluster_11 mE1_20_mRNA_expression_cluster_06
External Data & Images
Linkouts	BDGP expression data • PC00485 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0003117 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG3978-RB
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal | embryonic stage pnrVX6 lethal | embryonic stage | recessive pnr1 pnrD1 pnrD1R+1 pnrD1R+2 pnrD2 pnrD2R+1 pnrD2R+2 pnrD3 pnrD4 pnrD4R+1 pnrD4R+2 pnrD4R+4 pnrD4R+5 pnrD4R+6 pnrunspecified pnrVP8 pnrVX6 pnrVX7 lethal | recessive pnrMD237 pnrVX1 pnrVX4 pnrVX6 pnrVX9 partially lethal - majority die (with pnrMD237) pnrVX6 partially lethal - majority die (with pnrVX6) pnrMD237 viable pnrf04283 pnrMD237 pnrV1 pnrVX2 pnrVX3 pnrVX5 viable, with Scer\GAL4pnr-MD237 pnrGD1511 pnrScer\UAS.cHa viable | poor, with Scer\GAL4pnr-MD237 pnrD4.Scer\UAS Sterility Allele fertile pnrf04283 Other Phenotypes Allele planar polarity defective | cell non-autonomous | recessive | somatic clone pnrVX6 planar polarity defective | cell non-autonomous | somatic clone, with Scer\GAL4Ubx.PdC pnrScer\UAS.cHa short lived, with Scer\GAL4tin.CΔ4 pnrEnR.Scer\UAS.T:Rep-en short lived | dominant pnrVX6 visible pnrCam pnrCamR+1 pnrMD237 visible, with Scer\GAL4bi-omb-Gal4 pnrD4.Scer\UAS visible, with Scer\GAL4C-765 pnrSA.Scer\UAS.β pnrScer\UAS.cHa pnrScer\UAS.β visible, with Scer\GAL4ey.PH pnrD4.Scer\UAS visible, with Scer\GAL4pnr-MD237 pnrD4.Scer\UAS pnrGD1511 pnrScer\UAS.cHa pnrVX4.Scer\UAS visible (with pnrMD237) pnrV1 pnrVX6 visible (with pnrV1) pnrMD237 visible (with pnrVX6) pnrMD237 visible | cell non-autonomous | recessive | somatic clone pnrVX6 visible | dominant pnrD1 pnrD2 pnrD3 pnrD4 pnrMD237 pnrVX1 pnrVX4 visible | somatic clone pnrVX6 Phenotype manifest in Allele adult abdomen | medial | somatic clone pnrVX6 adult head | dorsal | somatic clone pnrVX6 adult head | somatic clone pnrVX6 adult heart pnr1 pnrVX6 pnrVX1e adult heart, with Scer\GAL4how-24B pnrEnR.Scer\UAS.T:Rep-en adult heart, with Scer\GAL4tin.CΔ4 pnrEnR.Scer\UAS.T:Rep-en adult thorax | dorsal pnrMD237 amnioserosa pnrD1 pnrD2 pnrD3 pnrD4 pnrVX6 antenna | ectopic | somatic clone pnrVX6 anterior dorsocentral bristle pnrD1 pnrD2 pnrD3 pnrD4 pnrVX1 pnrVX4 pnrVX6 anterior dorsocentral bristle | supernumerary, with Scer\GAL4Bx-MS1096 pnrScer\UAS.cHa anterior orbital bristle pnrD4 anterior vertical bristle pnrCam pnrCamR+1 pnrD4 pnrMD237 pnrV1 pnrVX2 pnrVX3 pnrVX7 cardioblast pnr1 pnrVX6 cardioblast, with Scer\GAL4HCH.Hand pnrEnR.Scer\UAS.T:Rep-en cardioblast | ectopic, with Scer\GAL4twi.PB pnrScer\UAS.cHa cardioblast | supernumerary, with Scer\GAL4how-24B, Scer\GAL4twi.PG pnrScer\UAS.cHa cardioblast | supernumerary, with Scer\GAL4tin.cBa pnrScer\UAS.cHa cardiogenic mesoderm pnrVX6 cardiogenic mesoderm, with Scer\GAL4Mef2.PR pnrScer\UAS.cHa cardiogenic mesoderm, with Scer\GAL4twi.PG pnrScer\UAS.cHa chaeta pnrMD237 denticle belt, with Scer\GAL4Ubx.PdC pnrScer\UAS.cHa dorsal medial muscle (with pnrD1) pnrMD237 dorsal medial muscle (with pnrMD237) pnrD1 dorsal medial muscle (with pnrV1) pnrVX1 dorsal medial muscle (with pnrVX1) pnrV1 dorsocentral bristle pnrD1 pnrD2 pnrD3 pnrD4 pnrMD237 pnrV1 pnrVX1 pnrVX2 pnrVX3 pnrVX4 pnrVX5 dorsocentral bristle, with Scer\GAL4pnr-MD237 pnrD4.Scer\UAS pnrScer\UAS.cHa pnrVX4.Scer\UAS dorsocentral bristle (with pnrMD237) pnrV1 pnrVX6 dorsocentral bristle (with pnrV1) pnrMD237 dorsocentral bristle (with pnrVX6) pnrMD237 dorsocentral bristle | ectopic, with Scer\GAL4ost-em462 pnrScer\UAS.cHa dorsocentral bristle | ectopic (with pnrD1) pnrMD237 dorsocentral bristle | ectopic (with pnrMD237) pnrD1 dorsocentral bristle | supernumerary pnrD1 dorsocentral bristle | supernumerary, with Scer\GAL4ap-md544 pnrScer\UAS.cHa embryo | dorsal pnrunspecified embryonic/first instar larval cuticle | dorsal pnrVE12 pnrVE13 embryonic/larval cuticle pnrVX6 embryonic/larval dorsal vessel, with Scer\GAL4twi.PB pnrScer\UAS.cHa embryonic/larval lymph gland pnrVX6 embryonic/larval pericardial cell, with Scer\GAL4twi.PB pnrScer\UAS.cHa embryonic/larval pericardial cell | ectopic pnr1 embryonic/larval somatic muscle | dorsal, with Scer\GAL4twi.PB pnrScer\UAS.cHa embryonic/larval visceral muscle, with Scer\GAL4twi.PB pnrScer\UAS.cHa embryonic dorsal epidermis pnr1 pnrD1 pnrD1R+1 pnrD1R+2 pnrD2 pnrD2R+1 pnrD2R+2 pnrD3 pnrD4 pnrD4R+1 pnrD4R+2 pnrD4R+4 pnrD4R+5 pnrD4R+6 pnrVX6 embryonic epidermis pnr1 pnrunspecified embryonic epidermis, with Scer\GAL4arm.PS pnrScer\UAS.cHa embryonic epidermis, with Scer\GAL4Ubx.PdC pnrScer\UAS.cHa embryonic epidermis | anterior compartment, with Scer\GAL4wg-MD758 pnrScer\UAS.cHa embryonic epidermis | posterior compartment, with Scer\GAL4en-e16E pnrScer\UAS.cHa embryonic garland cell, with Scer\GAL4HCH.Hand pnrEnR.Scer\UAS.T:Rep-en embryonic pericardial cell pnr1 pnrVX6 embryonic pericardial cell, with Scer\GAL4Mef2.PR pnrScer\UAS.cHa embryonic pericardial cell, with Scer\GAL4twi.PG pnrScer\UAS.cHa epidermis | dorsal pnrVP8 eye, with Scer\GAL4bi-omb-Gal4 pnrD4.Scer\UAS eye, with Scer\GAL4ey.PH pnrD4.Scer\UAS eye | cell non-autonomous | ectopic | somatic clone pnrVX6 eye | dorsal | somatic clone pnrVX6 eye | somatic clone pnrVX6 eye disc, with Scer\GAL4ey.PH pnrD4.Scer\UAS eye disc | dorsal | somatic clone pnrVX6 eye equator | ectopic | somatic clone pnrVX6 head pnrMD237 pnrV1 pnrVX2 pnrVX3 heart primordium pnrVX6 pnrdsRNA.cKa pnrdsRNA.si.cKa lymph gland primordium, with Scer\GAL4HCH.Hand pnrEnR.Scer\UAS.T:Rep-en lymph gland primordium, with Scer\GAL4Mef2.PR pnrScer\UAS.cHa lymph gland primordium, with Scer\GAL4twi.PG pnrScer\UAS.cHa macrochaeta pnrMD237 pnrV1 pnrVX2 macrochaeta, with Scer\GAL4C-765 pnrScer\UAS.cHa macrochaeta | ectopic, with Scer\GAL4C-765 pnrScer\UAS.β pnrSA.Scer\UAS.β macrochaeta | ectopic | somatic clone, with Scer\GAL4Ubx.PdC pnrScer\UAS.cHa mesothoracic cleft pnr1 pnrCam pnrD1 pnrD3 pnrD4 pnrMD237 pnrVX5 pnrVX6 mesothoracic tergum, with Scer\GAL4pnr-MD237 pnrGD1511 mesothoracic tergum (with pnrD1) pnrMD237 mesothoracic tergum (with pnrMD237) pnrD1 mesothoracic tergum | cell autonomous | ectopic | somatic clone, with Scer\GAL4Ubx.PdC pnrScer\UAS.cHa mesothoracic tergum | ectopic, with Scer\GAL4ap-md544 pnrScer\UAS.cHa mesothoracic tergum | ectopic, with Scer\GAL4bi-omb-Gal4 pnrScer\UAS.cHa mesothoracic tergum | ectopic, with Scer\GAL4Bx-MS1096 pnrScer\UAS.cHa mesothoracic tergum | ectopic, with Scer\GAL4C-765 pnrScer\UAS.cHa mesothoracic tergum | ectopic, with Scer\GAL4nub-AC-62 pnrScer\UAS.cHa mesothoracic tergum | ectopic, with Scer\GAL4vg.quadrant pnrScer\UAS.cHa mesothoracic tergum | lateral, with Scer\GAL4ap-md544 pnrScer\UAS.cHa mesothoracic tergum | lateral | somatic clone, with Scer\GAL4Ubx.PdC pnrScer\UAS.cHa mesothoracic tergum | medial | somatic clone pnrVX6 microchaeta | ectopic | somatic clone, with Scer\GAL4Ubx.PdC pnrScer\UAS.cHa microchaeta | supernumerary, with Scer\GAL4ap-md544 pnrScer\UAS.cHa photoreceptor cell | ectopic | somatic clone pnrVX6 photoreceptor cell | somatic clone pnrVX6 posterior dorsocentral bristle pnrD1 pnrD2 pnrD3 pnrD4 pnrVX1 pnrVX4 pnrVX6 posterior dorsocentral bristle | supernumerary, with Scer\GAL4Bx-MS1096 pnrScer\UAS.cHa postnotum | cell autonomous | ectopic | somatic clone, with Scer\GAL4Ubx.PdC pnrScer\UAS.cHa postvertical bristle pnrCam pnrCamR+1 pnrD1 pnrD4 pnrMD237 pnrV1 pnrVX2 presutural bristle pnrVX9 scutellar bristle pnrD1 pnrD2 pnrD4 pnrV1 pnrVX1 scutellar bristle (with pnrMD237) pnrV1 scutellar bristle (with pnrV1) pnrMD237 scutellar bristle | supernumerary pnrD1 scutellar bristle | supernumerary, with Scer\GAL4pnr-MD237 pnrScer\UAS.cHa scutellum pnrVX6 scutum, with Scer\GAL4C-765 pnrScer\UAS.cHa sensory mother cell | ectopic, with Scer\GAL4C-765 pnrScer\UAS.cHa sternite, with Scer\GAL4Dll-MD743 pnrScer\UAS.cHa tergite | ectopic, with Scer\GAL4Dll-MD743 pnrScer\UAS.cHa ventral nerve cord, with Scer\GAL4Ubx.PdC pnrScer\UAS.cHa wing pnrD4R+6 wing, with Scer\GAL4ap-md544 pnrScer\UAS.cHa wing, with Scer\GAL4bi-omb-Gal4 pnrScer\UAS.cHa wing, with Scer\GAL4Bx-MS1096 pnrScer\UAS.cHa wing, with Scer\GAL4C-765 pnrScer\UAS.cHa wing, with Scer\GAL4nub-AC-62 pnrScer\UAS.cHa wing, with Scer\GAL4vg.quadrant pnrScer\UAS.cHa wing | somatic clone, with Scer\GAL4Ubx.PdC pnrScer\UAS.cHa wing vein pnrVX9
Classical Alleles ( 34 )
For All Classical Alleles Show
Allele of pnr Class Mutagen Stocks Known lesion pnrMD237 neomorphic allele - genetic evidence, loss of function allele, hypomorphic allele - genetic evidence Delta2-3 P-element activity 3 -- pnrVX6 amorphic allele - genetic evidence, loss of function allele X ray 2 Yes pnr1 loss of function allele ethyl methanesulfonate 2 Yes pnrf04283 piggyBac transposase 2 -- pnrD1 antimorphic allele - genetic evidence, loss of function allele, gain of function allele ethyl methanesulfonate 1 Yes pnrV1 gain of function allele, hypomorphic allele - genetic evidence spontaneous 1 -- pnrVX4 antimorphic allele - genetic evidence, gain of function allele X ray 1 Yes pnrD1R+1 amorphic allele - genetic evidence ethyl methanesulfonate 0 -- pnrD1R+2 amorphic allele - genetic evidence ethyl methanesulfonate 0 -- pnrD2R+1 amorphic allele - genetic evidence ethyl methanesulfonate 0 -- pnrD2R+2 amorphic allele - genetic evidence ethyl methanesulfonate 0 -- pnrD4R+2 amorphic allele - genetic evidence X ray 0 Yes pnrD4R+5 amorphic allele - genetic evidence X ray 0 Yes pnrD4R+6 amorphic allele - genetic evidence X ray 0 -- pnrVX7 amorphic allele - genetic evidence X ray 0 -- pnr2 ethyl methanesulfonate 0 -- pnrCam X ray 0 Yes pnrCamR+1 spontaneous 0 -- pnrD2 antimorphic allele - genetic evidence, gain of function allele ethyl methanesulfonate 0 Yes pnrD2R+3 wild-type allele ethyl methanesulfonate 0 -- pnrD3 antimorphic allele - genetic evidence, gain of function allele ethyl methanesulfonate 0 Yes pnrD4 antimorphic allele - genetic evidence, gain of function allele ethyl methanesulfonate 0 Yes pnrD4R+1 hypomorphic allele - genetic evidence ethyl methanesulfonate 0 -- pnrD4R+4 antimorphic allele - genetic evidence X ray 0 -- pnrunspecified 0 -- pnrVE12 loss of function allele ethyl methanesulfonate 0 Yes pnrVE13 loss of function allele ethyl methanesulfonate 0 Yes pnrVP8 P-element activity Delta2-3 0 Yes pnrVX1 antimorphic allele - genetic evidence, gain of function allele X ray 0 Yes pnrVX1e 0 -- pnrVX2 hypomorphic allele - genetic evidence X ray 0 -- pnrVX3 hypomorphic allele - genetic evidence X ray 0 -- pnrVX5 hypomorphic allele - genetic evidence X ray 0 -- pnrVX9 neomorphic allele - genetic evidence X ray 0 --
Alleles Carried on Transgenic Constructs ( 30 )
For All Alleles Carried on Transgenic Constructs Show
Allele of pnr Class Mutagen Stocks Known lesion pnrD4.Scer\UAS in vitro construct - regulatory fusion 1 Yes pnrGD1511 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes pnrHM05146 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes pnrHMS00570 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes pnrHMS01082 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes pnrHMS01136 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes pnrKK108962 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes pnrScer\UAS.cHa in vitro construct - regulatory fusion 1 Yes pnr1-457.Scer\UAS in vitro construct - regulatory fusion 0 -- pnr1-540.Scer\UAS in vitro construct - regulatory fusion 0 -- pnrAct5C.PH in vitro construct - regulatory fusion 0 Yes pnrC190S.Scer\UAS in vitro construct - regulatory fusion in vitro construct - amino acid replacement 0 Yes pnrC247S.Scer\UAS in vitro construct - regulatory fusion in vitro construct - amino acid replacement 0 Yes pnrD242S.Scer\UAS in vitro construct - regulatory fusion in vitro construct - amino acid replacement 0 Yes pnrdsRNA.cKa in vitro construct - RNAi 0 Yes pnrdsRNA.si.cKa in vitro construct - RNAi 0 Yes pnrE168K.Scer\UAS in vitro construct - regulatory fusion in vitro construct - amino acid replacement 0 Yes pnrEnR.Scer\UAS.T:Rep-en in vitro construct - coding region fusion in vitro construct - deletion in vitro construct - regulatory fusion 0 Yes pnrFL.Act5C.T:Hsap\MYC in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes pnrfl.cFa in vitro construct 0 Yes pnrG184R.Scer\UAS in vitro construct - regulatory fusion in vitro construct - amino acid replacement 0 Yes pnrNIG.3978R in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes pnrSA.Scer\UAS.β in vitro construct - regulatory fusion in vitro construct - amino acid replacement 0 Yes pnrScer\UAS.β in vitro construct - regulatory fusion 0 Yes pnrVX4.Scer\UAS in vitro construct - regulatory fusion 0 Yes pnrΔC.Act5C.T:Hsap\MYC in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes pnrΔN.Act5C.T:Hsap\MYC in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes pnrΔZf.Act5C.T:Hsap\MYC in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes pnrΔZf1.Act5C.T:Hsap\MYC in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes pnrΔZf2.Act5C.T:Hsap\MYC in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(3R)Exel7327 (Ryder, 2004.4.26) Df(3R)Exel7328 (Ryder, 2004.4.26) Df(3R)pnrD4R+3 (Heitzler et al., 1996) Df(3R)sbd45 (Tomoyasu et al., 2000, Jurgens et al., 1984, Tearle and Nusslein-Volhard, 1987, Nelson and Szauter, 1992, Heitzler et al., 1996) Df(3R)sbd105 (Jurgens et al., 1984, Nelson and Szauter, 1992, Harbecke and Lengyel, 1995, Heitzler et al., 1996) In(3LR)pnrVX3 (Heitzler et al., 1996) In(3R)pnrVX2 (Heitzler et al., 1996) In(3R)pnrVX5 (Heitzler et al., 1996) Tp(3;3)sbd104 (Heitzler et al., 1996)
Not disrupted in	Df(3R)c(3)G-2 (Nelson and Szauter, 1992) Df(3R)E8-89B-Rev2 (Heitzler et al., 1996) Df(3R)Po2 (Nelson and Szauter, 1992) Df(3R)Po3 (Nelson and Szauter, 1992) Df(3R)Po4 (Nelson and Szauter, 1992) Df(3R)sbd26 (Nelson and Szauter, 1992, Heitzler et al., 1996)
Duplicated in	Dp(3;3)BK43 (Ramain et al., 1993, Heitzler et al., 1996) Dp(3;3)BK44 (Heitzler et al., 1996)
Not duplicated in	Ts(1Rt;3Rt)OR60+Ts(1Lt;3Lt)89Bq2 (Heitzler et al., 1996)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD1511} NA P{KK108962} NA P{NIG.3978R} NA P{TRiP.HM05146} NA P{TRiP.HMS00570} NA P{TRiP.HMS01082} NA P{TRiP.HMS01136} NA P{UAS-pnr.1-457} NA P{UAS-pnr.1-540} NA P{UAS-pnr.C190S} NA P{UAS-pnr.C247S} NA P{UAS-pnr.D4} NA P{UAS-pnr.D242S} NA P{UAS-pnr.E168K} NA P{UAS-pnr.EnR} NA P{UAS-pnr.G184R} NA P{UAS-pnr.H} NA P{UAS-pnr.VX4} NA P{UAS-pnr.β.SA} NA P{UAS-pnr.β} NA reporter construct P{pnr-lacZ.457.mutTin1/2} No P{pnr-lacZ.457.mutTin1} No P{pnr-lacZ.457.mutTin2} No P{pnr-lacZ.457} No P{pnr-lacZ.P1} No P{pnr-lacZ.P2.3} No P{pnr-lacZ.P2} No P{pnr-lacZ.P3} No P{pnr-lacZ.P4} No
Insertions
	Type of insertions Name Expression data miscellaneous insertions P{}pnrVP8 NA PBac{WH}pnrf04283 NA insertion of enhancer trap binary system P{GawB}pnrMD237 No
Gene Ontology: Function, Process & Cellular Component ( 33 unique terms )
Terms Based on Experimental Evidence ( 21 terms )
Molecular Function
CV term Evidence References
protein binding inferred from physical interaction with Bx (Zenvirt et al., 2008) inferred from physical interaction with Chi (Vanolst et al., 2005) inferred from physical interaction with Iswi (Vanolst et al., 2005) inferred from physical interaction with tou (Vanolst et al., 2005) protein heterodimerization activity inferred from physical interaction with ush (Haenlin et al., 1997) RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity inferred from direct assay (Haenlin et al., 1997) RNA polymerase II repressing transcription factor binding inferred from physical interaction with ush (Haenlin et al., 1997) RNA polymerase II transcription factor binding inferred from physical interaction with tup (Biryukova and Heitzler, 2005) sequence-specific DNA binding inferred from direct assay (Haenlin et al., 1997) sequence-specific DNA binding RNA polymerase II transcription factor activity inferred from direct assay (Haenlin et al., 1997)
Biological Process
CV term Evidence References
blastoderm segmentation inferred from mutant phenotype (Calleja et al., 2000) cardioblast cell fate determination inferred from mutant phenotype (Klinedinst and Bodmer, 2003) cardioblast differentiation inferred from mutant phenotype (Alvarez et al., 2003, Mandal et al., 2004) cardiocyte differentiation inferred from mutant phenotype (Reim and Frasch, 2005) chaeta development inferred from genetic interaction with CtBP (Stern et al., 2009) dorsal closure inferred from mutant phenotype (Heitzler, 2006.8.9) embryonic heart tube development inferred from mutant phenotype (Qian et al., 2005, Han and Olson, 2005) heart contraction inferred from mutant phenotype (Qian and Bodmer, 2009) lymph gland development inferred from mutant phenotype (Mandal et al., 2004, Han and Olson, 2005) pericardial nephrocyte differentiation inferred from mutant phenotype (Alvarez et al., 2003, Mandal et al., 2004) pigment metabolic process inferred from mutant phenotype (Calleja et al., 2002) positive regulation of transcription from RNA polymerase II promoter inferred from direct assay (Haenlin et al., 1997) regulation of antimicrobial peptide biosynthetic process inferred from mutant phenotype (Valanne et al., 2010)
Cellular Component
CV term Evidence References
nucleus inferred from direct assay (Reim and Frasch, 2005)
Terms Based on Predictions or Assertions ( 14 terms )
Molecular Function
CV term Evidence References
sequence-specific DNA binding transcription factor activity inferred from sequence or structural similarity (Swiss-Prot Project Members, 1998.7.15) traceable author statement (Calleja et al., 2000) zinc ion binding inferred from electronic annotation with InterPro:IPR000679, InterPro:IPR013088 (FlyBase Curators et al., 2004-)
Biological Process
CV term Evidence References
cell differentiation non-traceable author statement (Cripps and Olson, 2002) chaeta morphogenesis traceable author statement (Evans and Banerjee, 2003, Skaer et al., 2002) dorsal closure traceable author statement (Calleja et al., 2000, Lamka and Lipshitz, 1999, Harden, 2002) ectoderm development traceable author statement (Raftery and Sutherland, 2003) heart development traceable author statement (Chen and Fishman, 2000, Cripps and Olson, 2002) mesoderm development non-traceable author statement (Skeath et al., 2003) negative regulation of transcription, DNA-dependent traceable author statement (Calleja et al., 2002) pattern specification process non-traceable author statement (Calleja et al., 2002) positive regulation of transcription, DNA-dependent non-traceable author statement (Calleja et al., 2002) regulation of transcription, DNA-dependent inferred from sequence or structural similarity (Swiss-Prot Project Members, 1998.7.15) transforming growth factor beta receptor signaling pathway traceable author statement (Harden, 2002)
Cellular Component
CV term Evidence References
nucleus inferred by curator from GO:0000981 (Haenlin et al., 1997) inferred from sequence or structural similarity (Swiss-Prot Project Members, 1998.7.15)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
protein-protein
Interacting group Assay References
pnr - 128up anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) pnr - Arpc4 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) pnr - CG10306 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) pnr - CG10418 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) pnr - CG11266 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) pnr - CG15220 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) pnr - CG3862 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) pnr - CG4553 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) pnr - CG4619 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) pnr - CG5945 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) pnr - CG9769 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) pnr - Hsc70-1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) pnr - Imp anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) pnr - LRP1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) pnr - Nurf-38 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) pnr - Pgam5 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) pnr - RPA2 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) pnr - Saf-B anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) pnr - TFAM anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) pnr - Tango7 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) pnr - eIF3-S8 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) pnr - mRpS24 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) pnr - mRpS28 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) pnr - nito anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) pnr - nonA-l anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) pnr - nop5 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) pnr - tyf anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23)
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions pnr allele Gene References pnrD1 osa (Heitzler et al., 2003) ush (Cubadda et al., 1997) pnrMD237 Akap200 (Pena-Rangel et al., 2002) akirin (Pena-Rangel et al., 2002) Arf51F (Pena-Rangel et al., 2002) Atx2 (Pena-Rangel et al., 2002) Bx (Pena-Rangel et al., 2002) CG3776 (Pena-Rangel et al., 2002) CG5180 (Pena-Rangel et al., 2002) CG6701 (Pena-Rangel et al., 2002) CG8051 (Pena-Rangel et al., 2002) CG8116 (Pena-Rangel et al., 2002) CG8219 (Pena-Rangel et al., 2002) CG10962 (Pena-Rangel et al., 2002) CG11138 (Pena-Rangel et al., 2002) CG12084 (Pena-Rangel et al., 2002) CG30497 (Pena-Rangel et al., 2002) CG31176 (Pena-Rangel et al., 2002) CG43759 (Pena-Rangel et al., 2002) ckd (Pena-Rangel et al., 2002) CRMP (Pena-Rangel et al., 2002) CtBP (Pena-Rangel et al., 2002) D1 (Pena-Rangel et al., 2002) Dad (Pena-Rangel et al., 2002) Dek (Pena-Rangel et al., 2002) Drak (Pena-Rangel et al., 2002) Dsp1 (Pena-Rangel et al., 2002) Eaf (Pena-Rangel et al., 2002) EP416 (Pena-Rangel et al., 2002) EP639 (Pena-Rangel et al., 2002) EP853 (Pena-Rangel et al., 2002) EP1020 (Pena-Rangel et al., 2002) EP1062 (Pena-Rangel et al., 2002) EP1065 (Pena-Rangel et al., 2002) EP1081 (Pena-Rangel et al., 2002) EP1095 (Pena-Rangel et al., 2002) EP1113 (Pena-Rangel et al., 2002) EP1125 (Pena-Rangel et al., 2002) EP1139 (Pena-Rangel et al., 2002) EP1154 (Pena-Rangel et al., 2002) EP1191 (Pena-Rangel et al., 2002) EP1230 (Pena-Rangel et al., 2002) EP1236 (Pena-Rangel et al., 2002) EP1246 (Pena-Rangel et al., 2002) EP1340 (Pena-Rangel et al., 2002) EP1350 (Pena-Rangel et al., 2002) EP1408 (Pena-Rangel et al., 2002) EP1581 (Pena-Rangel et al., 2002) Hmt-1 (Pena-Rangel et al., 2002) Hr4 (Pena-Rangel et al., 2002) inaE (Pena-Rangel et al., 2002) mir-278 (Pena-Rangel et al., 2002) mmy (Pena-Rangel et al., 2002) Nab2 (Pena-Rangel et al., 2002) Orct2 (Pena-Rangel et al., 2002) Patr-1 (Pena-Rangel et al., 2002) Tl (Pena-Rangel et al., 2002) trx (Pena-Rangel et al., 2002) pnrVX6 L (Singh and Choi, 2003) wg (Maurel-Zaffran and Treisman, 2000) unspecified amn (Pena-Rangel et al., 2002) bib (Pena-Rangel et al., 2002) btn (Pena-Rangel et al., 2002) bun (Pena-Rangel et al., 2002) cbt (Pena-Rangel et al., 2002) CG5261 (Pena-Rangel et al., 2002) CG9932 (Pena-Rangel et al., 2002) chn (Escudero et al., 2005) chrb (Pena-Rangel et al., 2002) dgo (Pena-Rangel et al., 2002) Doc1 (Reim and Frasch, 2005) Doc2 (Reim and Frasch, 2005) Doc3 (Reim and Frasch, 2005) dpp (Pena-Rangel et al., 2002) eIF-1A (Pena-Rangel et al., 2002) elB (Pena-Rangel et al., 2002) emc (Pena-Rangel et al., 2002) EP339 (Pena-Rangel et al., 2002) EP344 (Pena-Rangel et al., 2002) EP374 (Pena-Rangel et al., 2002) EP382 (Pena-Rangel et al., 2002) EP393 (Pena-Rangel et al., 2002) EP417 (Pena-Rangel et al., 2002) EP443 (Pena-Rangel et al., 2002) EP474 (Pena-Rangel et al., 2002) EP531 (Pena-Rangel et al., 2002) EP646 (Pena-Rangel et al., 2002) EP707 (Pena-Rangel et al., 2002) EP787 (Pena-Rangel et al., 2002) EP873 (Pena-Rangel et al., 2002) EP924 (Pena-Rangel et al., 2002) EP950 (Pena-Rangel et al., 2002) EP995 (Pena-Rangel et al., 2002) EP1371 (Pena-Rangel et al., 2002) EP1388 (Pena-Rangel et al., 2002) EP1421 (Pena-Rangel et al., 2002) EP1501 (Pena-Rangel et al., 2002) EP1509 (Pena-Rangel et al., 2002) EP1555 (Pena-Rangel et al., 2002) EP1570 (Pena-Rangel et al., 2002) EP1595 (Pena-Rangel et al., 2002) EP2086 (Pena-Rangel et al., 2002) EP2087 (Pena-Rangel et al., 2002) EP2146a (Pena-Rangel et al., 2002) EP2416 (Pena-Rangel et al., 2002) EP2419 (Pena-Rangel et al., 2002) EP2433 (Pena-Rangel et al., 2002) EP2448 (Pena-Rangel et al., 2002) EP2595 (Pena-Rangel et al., 2002) EP3068 (Pena-Rangel et al., 2002) EP3085 (Pena-Rangel et al., 2002) EP3087 (Pena-Rangel et al., 2002) EP3135 (Pena-Rangel et al., 2002) EP3140 (Pena-Rangel et al., 2002) EP3186 (Pena-Rangel et al., 2002) EP3223 (Pena-Rangel et al., 2002) EP3263 (Pena-Rangel et al., 2002) EP3283 (Pena-Rangel et al., 2002) EP3306 (Pena-Rangel et al., 2002) EP3390 (Pena-Rangel et al., 2002) EP3621 (Pena-Rangel et al., 2002) EP3714 (Pena-Rangel et al., 2002) esg (Pena-Rangel et al., 2002) faf (Pena-Rangel et al., 2002) Fmr1 (Pena-Rangel et al., 2002) Fs(2)Ket (Pena-Rangel et al., 2002) glec (Pena-Rangel et al., 2002) Gli (Pena-Rangel et al., 2002) GstS1 (Pena-Rangel et al., 2002) H15 (Qian et al., 2005) Hop (Pena-Rangel et al., 2002) Hr39 (Pena-Rangel et al., 2002) Hsp22 (Pena-Rangel et al., 2002) insc (Pena-Rangel et al., 2002) kibra (Pena-Rangel et al., 2002) kis (Pena-Rangel et al., 2002) Kr-h1 (Pena-Rangel et al., 2002) L (Singh et al., 2005) l(2)k10113 (Pena-Rangel et al., 2002) l(3)L0539 (Pena-Rangel et al., 2002) l(3)L1022 (Pena-Rangel et al., 2002) l(3)L4092 (Pena-Rangel et al., 2002) lap (Pena-Rangel et al., 2002) Lig4 (Pena-Rangel et al., 2002) lin-28 (Pena-Rangel et al., 2002) Mef2 (Pena-Rangel et al., 2002) MESR4 (Pena-Rangel et al., 2002) mid (Qian et al., 2005) Myd88 (Pena-Rangel et al., 2002) NFAT (Pena-Rangel et al., 2002) Pc (Pena-Rangel et al., 2002) Pdi (Pena-Rangel et al., 2002) ppo (Pena-Rangel et al., 2000, Pena-Rangel et al., 2002) ps (Pena-Rangel et al., 2002) ptc (Pena-Rangel et al., 2002) pum (Pena-Rangel et al., 2002) qsm (Pena-Rangel et al., 2002) Rac2 (Pena-Rangel et al., 2002) ras (Pena-Rangel et al., 2002) RhoGEF64C (Pena-Rangel et al., 2002) RnpS1 (Pena-Rangel et al., 2002) sd (Pena-Rangel et al., 2002) shn (Pena-Rangel et al., 2002) smo (Pena-Rangel et al., 2002) spi (Pena-Rangel et al., 2002) stg (Pena-Rangel et al., 2002) svr (Pena-Rangel et al., 2002) tai (Pena-Rangel et al., 2002) tara (Pena-Rangel et al., 2002) tin (Reim and Frasch, 2005) tlk (Pena-Rangel et al., 2002) tou (Pena-Rangel et al., 2002) tup (Biryukova and Heitzler, 2005) XNP (Pena-Rangel et al., 2002)
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 69326 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0003117 DroID - A comprehensive database of gene and protein interactions. • FBgn0003117 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 44849
Orthologs
OrthoDB Orthologs (50) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG64QTK7 Dipteran inclusive ortholog search EOG6RXZ74 Insect inclusive ortholog search EOG6FQZMW Arthropod inclusive ortholog search EOG62547X Metazoa inclusive ortholog search EOG6TFCCG
Orthologs in Drosophila Species (EOG64QTK7)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\CG12885     Drosophila melanogaster fruit fly  Dmel\scrib     Drosophila melanogaster fruit fly  Dmel\pnr     Drosophila simulans   Dsim\GD21289   Y Drosophila sechellia   Dsec\GM21540   Y Drosophila sechellia   Dsec\GM10328   Y Drosophila erecta   Dere\GG11485   Y Drosophila yakuba   Dyak\GE23676   Y Drosophila ananassae   Dana\GF16442   Y Drosophila pseudoobscura pseudoobscura   Dpse\GA18897   Y Drosophila persimilis   Dper\GL23097   Y Drosophila willistoni   Dwil\GK13318   Y Drosophila mojavensis   Dmoj\GI22874   Y Drosophila grimshawi   Dgri\GH18723   Y
Orthologs in non-Drosophila Dipterans (EOG6RXZ74)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL002336 Y Anopheles gambiae Malaria mosquito  Agam\AGAP000054 Y Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ006376 Y
Orthologs in non-Dipteran Insects (EOG6FQZMW)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\GB53149 Y Apis mellifera Western honey bee  Amel\GB53150 Y Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG011031 Y Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH15226 Y Atta cephalotes Leafcutter ant  Acep\ACEP19189 Y Camponotus floridanus Florida carpenter ant  Cflo\CFLO15562 Y Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL14866 Y Linepithema humile Argentine ant  Lhum\LH20400 Y Pogonomyrmex barbatus Red harvester ant  Pbar\PB24314 Y Pogonomyrmex barbatus Red harvester ant  Pbar\PB24316 Y Solenopsis invicta Red fire ant  Sinv\SINV14539 Y Acyrthosiphon pisum Pea aphid  Apim\ACYPI004696 Y Bombyx mori Silkmoth  Bmor\BGIBMGA006516 Y Pediculus humanus Human body louse  Phum\PHUM127710 Y Tribolium castaneum Red flour beetle  Tcas\TC011397 Y
Orthologs in non-Insect Arthropods (EOG62547X)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\Mrpl14 Y Daphnia pulex Water flea  Dpux\psmb9a Y Ixodes scapularis Deer tick  Isca\ISCW024675 Y Ixodes scapularis Deer tick  Isca\ISCW019590 Y
Orthologs in non-Arthropod Metazoa (EOG6TFCCG)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Caenorhabditis elegans Nematode  Cele\let-413 Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_002555gn Y Danio rerio Zebrafish  Drer\lrrc1 Y Danio rerio Zebrafish  Drer\scrib Y Xenopus tropicalis Western clawed frog  Xtro\lrrc1 Y Xenopus tropicalis Western clawed frog  Xtro\scrib Y Gallus gallus Domestic chicken  Ggal\SCRIB Y Gallus gallus Domestic chicken  Ggal\LRRC1 Y Mus musculus House mouse  Mmus\Lrrc1 Y Mus musculus House mouse  Mmus\Scrib Y Rattus norvegicus Norway rat  Rnor\Scrib Y Rattus norvegicus Norway rat  Rnor\Lrrc1 Y Homo sapiens Human  Hsap\ENSG00000180900 Y Homo sapiens Human  Hsap\LRRC1 Y
Human Orthologs (2)
Gene OMIM HGNC Hsap\ENSG00000180900     Hsap\LRRC1
AAA Orthologs (11) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD19069 Drosophila sechellia Dsec\GM24279 Drosophila erecta Dere\GG16973 Drosophila yakuba Dyak\GE24361 Drosophila ananassae Dana\GF11891 Drosophila pseudoobscura pseudoobscura Dpse\GA17817 Drosophila persimilis Dper\GL12215 Drosophila willistoni Dwil\GK13255 Drosophila virilis Dvir\GJ23378 Drosophila mojavensis Dmoj\GI22649 Drosophila grimshawi Dgri\GH18759
Stocks & Reagents
Stocks Listed in FlyBase ( 20 )
Bloomington	36546 w*; P{UAS-pnr.D4}2 7223 w*; P{UAS-pnr.H}13/CyO 18754 w1118; PBac{WH}pnrf04283 28935 y1 v1; P{TRiP.HM05146}attP2 36551 mwh1 jv1 pnrD1/TM2 33697 y1 sc* v1; P{TRiP.HMS00570}attP2 33744 y1 sc* v1; P{TRiP.HMS01082}attP2 34659 y1 sc* v1; P{TRiP.HMS01136}attP2 6334 w*; P{neoFRT}82B pnrVX6/TM6B, Tb+
Harvard	- PBac{WH}pnrf04283
VDRC	v101522 P{KK108962}VIE-260B v6224 w1118; P{GD1511}v6224
	More stocks available...
Genomic Clones ( 2 )
	BACR04C07 BACR05C20 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 215 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	RE17974 RE33290 SD02611
Other clones	DPiM_RE17974
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	LP03918 RE44750 SD03008 SD10154 SD15838 SD18716 SD19795 SD21068 SD24193 SD25893 SD26669
Other clones	35821 55233 66145 71435 79525 121366 149592 214219.46 214219.47 214445.36 214513.40 214543.62 275137 523101 523687 557158 569933 EK165225 EK173040 EK181854 EK193960 EK199641 EK241428 EK251356 EK302840 EN03423 EN04116 EN05506 EN06606 EN12148 EN15922 EP00444 EP06740 EP07940 EP11756 RP003000386 RP003001121 RP003011323 RP003011454 RP003017807 RP003019201 RP003029637 RP003030643 RP003031064 RP003032459 RP003032613 RP003034748 RP003036778 RP003036962 RP003051165 RP003054471 RP003060074 RP003067507 RP003069463 RP003069791 RP003070317 RP003076326 RP003076502 RP003087698 RP003089756 RP003091784 RP003099353 RP003103293 RP003105702 RP003105968 RP003118457 RP003120985 RP003122022 RP003127736 RP003133192 RP003151224 RP003159152 RP003169787 RP003172348 RP003174677 RP003179282 RP003182378 RP003182397 RP003185318 RP003185895 RP003187134 RP003189097 RP003191645 RP003192598 RP003199132 RP003202270 RP003202579 RP003205264 RP003206465 RP003216900 RP003217116 RP003221560 RP003221907 RP003225834 RP003229359 RP003229725 RP003234507 RP003236472 RP003236592 RP003243761 RP003246027 RP003247923 RP003250209 RP003254866 RP003279605 RP003279738 RP003280002 RP003283020 RP003288398 RP003290741 RP003293255 RP003293716 RP003295161 RP003310163 RP003311723 RP003314546 RP003314675 RP003319550 RP003330870 RP003331146 RP003343746 RP003351878 RP003357559 RP003361153 RP003361969 RP003365990 RP003368775 RP003372618 RP003374721 RP003380274 RP003380296 RP003380866 RP003382722 RP003391240 RP003394979 RP003396497 RP003405085 RP003410121 RP003412991 RP003414231 RP003415914 RP003416975 RP003418375 RP003421621 RP003424831 RP003426859 RP003439591 RP003444883 RP003446838 RP003448089 RP003451663 RP003463368 RP003463577 RP003464764 RP003467442 RP003478401 RP003479650 RP003481620 RP003483360 RP003486030 RP003487065 RP003490990 RP003492544 RP003493087 RP003506160 RP003506698 RP003508250 RP003514650 RP003515036 RP003516835 RP003517969 RP003518004 RP003527387 RP003531609 RP003531840 RP003532028 RP003533095 RP003544800 RP003548256 RP003549604 RP003550802 RP003551131 RP003552247 RP003552417 RP003560968 RP003563058 RP003564394 RP003567166 RP003579503 RP003596917 RP003597730 RP003602620 RP003618978 RP003620719 RP003623273 RP003642352 RP003643227 RP003644131 RP003659643 RP003668021
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0003117 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 44849
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of	Source for merge of: pnr CG3978 (Bayraktaroglu, 2000.4.13)
Additional comments	pnr appears to be a chimeric gene, with the 5' part of the gene derived from grn and the 3' part of the gene derived from GATAe. (Rogers and Hartl, 2012) "pnr" is a putative chimeric gene derived from the "grn" and "GATAe" genes (where coding sequences of the two parental genes contribute to the coding sequence of the chimeric gene). (Rogers et al., 2009)
Other Comments
	DNA-protein interactions: genome-wide binding profile assayed for pnr protein in stage 9-11 embryos; ArrayExpress accession number E-MTAB-1184. (Junion et al., 2012) tou, pnr and Chi co-operate during neural development. (Vanolst et al., 2005) pnr is required for the development of all cardiogenic mesoderm. (Mandal et al., 2004) pnr expression is controlled by the convergence of dpp, bnl, wg and N signalling. (Mandal et al., 2004) The pntP2 isoform is involved in heart development. (Alvarez et al., 2003) pnr is required to establish competence for heart progenitor formation. (Klinedinst and Bodmer, 2003) pnr is a direct transcriptional target of tin in the heart-forming region. (Gajewski et al., 2001) pnr may be the principle gene responsible for the subdivision of the medial and lateral regions of each dorsal segment. (Calleja et al., 2000) pnr acts upstream of wg to control mirr and fng expression and establish the dorsoventral boundary in the eye. (Maurel-Zaffran and Treisman, 2000) The pnr/ush complex serves as a repressor and a transcriptional activator, respectively for wg and ush expression. (Sato and Saigo, 2000) The dpp gradient may regulate notal wg expression through induction of pnr and ush. (Tomoyasu et al., 2000) pnr is required for cardial cell formation while repressing a pericardial cell fate in the developing embryo. (Gajewski et al., 1999) pnr directly activates the proneural ac and sc genes by binding to the enhancers responsible for their expression in the dorsocentral proneural cluster. pnr and ush are main effectors of the regulation of wg expression in the presumptive notum. (Garcia-Garcia et al., 1999) pnr and ush provide positional information for the patterning of the dorsocentral mechanosensory bristle cluster. (Garcia-Garcia et al., 1999) pnr acts as a negative regulator of wg in the notum. Some of the effects of pnr mutants are apparently produced through an alteration of wg function. (Calleja et al., 1996) Genetic and phenotypic analysis of pnr. pnr is required for viability of the cells of the amnioserosa. (Heitzler et al., 1996) Molecular analysis of pnr alleles reveals two functional domains of the pnr gene product. Mutants associated with lesions in the zinc finger domain show overexpression of ac and sc and the development of extra neural precursors. Mutations in the putative amphipathic helices act as hyperactive repressor molecules causing a loss of ac and sc expression and a loss of neural precursors. Activity of pnr may be modulated by association with position specific factors. (Ramain et al., 1993) Isolated on the basis of sequence similarity to mammalian GATA factors. Expression pattern suggests that it may function downstream of the zygotic pattern genes dpp and zen. (Winick et al., 1993) pnr mutants display failure of anterior dorsal closure. (Jurgens et al., 1984)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_057337 NM_169697 NM_001275691 NM_001275692 RefSeq (Proteins) • NP_476685 NP_732102 NP_001262620 NP_001262621 DDBJ / EMBL / GenBank • AAB29874 AAB29876 AAF55264 AAM11423 AAN13693 AC007726 AC007755 AGB96000 AGB96001 AI531528 AW944253 AY095095 CZ486816 S68793 S68795 S68798 S68802 S68803 S68909 Entrez Gene - A searchable database of RefSeq genes. • 44849 UniProtKB/Swiss-Prot • P52168 UniProtKB/TrEMBL • Q8T3J0 Q9VEZ8
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Zinc finger, NHR/GATA-type (IPR013088) Zinc finger, GATA-type (IPR000679) BDGP expression data - Patterns of gene expression in Drosophila embryogenesis • PC00485
Linkouts
	BioGRID - A database of protein and genetic interactions • 69326 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0003117 DroID - A comprehensive database of gene and protein interactions. • FBgn0003117 DRSC - Results from RNAi screens. • FBgn0003117 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0003117 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG3978-RB FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0003117 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 44849 Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution • /gene/pannier.htm InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 44849 modMine - Data generated by the modENCODE project. • FBgn0003117 REDfly - A database of transcriptional regulatory elements. • FBgn0003117
Synonyms & Secondary IDs ( 16 )
Reported As
Symbol Synonym	CG3978 (Kim et al., 2004, Rogers and Hartl, 2012, Keleman et al., 2009.8.5, Perkins et al., 2009, Ni et al., 2010.12.1, Hazelett et al., 2009) CG3978-PA (Rogers et al., 2009) dGATAa (Evans and Banerjee, 2003, Winick, 1994.9.22, Lossky and Wensink, 1995, Lin et al., 1995, Winick et al., 1993) dGATAa/pannier (Arendt and Nubler-Jung, 1997) GATA (Govind and Nehm, 2004, Olson, 2006) GATA4 (Amodio et al., 2012) GATAa (Teakle and Gilmartin, 1998) GATAa/Pannier (Brodu et al., 1999) l(3)89B3   pnr (Zenvirt et al., 2008, Ekas et al., 2006, Liang et al., 2007, Sellin et al., 2006, Biryukova and Heitzler, 2005, Heitzler, 2006.8.9, Akasaka et al., 2006, Akasaka et al., 2006, Mann et al., 2007, Zeitlinger et al., 2007, Simpson, 2006, Senger et al., 2006, Stathopoulos and Levine, 2005, Tie et al., 2012, Ash et al., 2007, Fromental-Ramain et al., 2008, de Navascués and Modolell, 2007, Davidson and Erwin, 2006, Kwong et al., 2008, Minakhina et al., 2007, Thomas et al., 2009, Fromental-Ramain et al., 2010, Hironaka et al., 2012, Liang et al., 2012, Nekrasov et al., 2007, Choksi et al., 2006, Marcellini and Simpson, 2006, Asmar et al., 2008, Weake et al., 2011, Parks et al., 2008, Parrish et al., 2007, Liu et al., 2009, Oktaba et al., 2008, Biryukova and Heitzler, 2008, Yang et al., 2012, Harbison et al., 2009, Pierre et al., 2008, Bantignies et al., 2011, Fang et al., 2009, Boettiger and Levine, 2009, Grimm et al., 2009, Stern et al., 2009, Flaherty et al., 2009, Gambetta et al., 2009, Gambetta et al., 2009, Qian and Bodmer, 2009, Grieder et al., 2009, Southon et al., 2008, Tuxworth et al., 2009, Tokusumi et al., 2007, de Navascués and Modolell, 2010, Weiss et al., 2010, Hazelett et al., 2009, Cherbas et al., 2011, Oros et al., 2010, Ryu et al., 2011, Amodio et al., 2012, Norgate et al., 2010, Ahmad et al., 2012, Japanese National Institute of Genetics, 2012.5.21, Valadez-Graham et al., 2012) Pnr (Mann and Carroll, 2002, Asmar et al., 2007, Biryukova and Heitzler, 2008, Pereira et al., 2006, Mann et al., 2009, Sorrentino et al., 2007, Junion et al., 2012) PNR (Bronstein et al., 2010) prn (Ramain, 1994.9.22)
Name Synonym	pannier (Andjelkovic et al., 1995, Liang et al., 2007, Simpson, 2006, Robinson, 2006, Fromental-Ramain et al., 2008, Olson, 2006, Pereira et al., 2006, Thomas et al., 2009, Fromental-Ramain et al., 2010, Liang et al., 2012, Nekrasov et al., 2007, Parks et al., 2008, Oktaba et al., 2008, Harbison et al., 2009, Gillis et al., 2008, Boettiger and Levine, 2009, Stern et al., 2009, Flaherty et al., 2009, Carpenter et al., 2009, Gambetta et al., 2009, Qian and Bodmer, 2009, Neely et al., 2010, Valanne et al., 2010, Weiss et al., 2010, Hazelett et al., 2009, Oros et al., 2010, Ryu et al., 2011, Valadez-Graham et al., 2012) Pannier (Akasaka et al., 2006, Asmar et al., 2007, Mann et al., 2007, Letizia et al., 2007, Ishihara and Shibata, 2008, Asmar et al., 2008, Grieder et al., 2009, Southon et al., 2008, Biryukova and Heitzler, 2008, Tokusumi et al., 2007, Norgate et al., 2010) PANNIER (Bronstein et al., 2010)
Secondary FlyBase IDs
	FBgn0038393
References ( 259 )
Generate a list of	All references relating to this gene ( 259 )
List References by type	Research paper  ( 146 ) Supplementary material  ( 6 ) Review  ( 43 ) Personal communication to FlyBase  ( 15 ) Abstract  ( 39 ) FlyBase analysis  ( 2 ) DNA/RNA sequence record  ( 3 ) Stock list  ( 2 ) Protein sequence record  ( 1 ) Website  ( 1 ) Book  ( 1 )
Recent research papers ( 18 )
	Ahmad et al., 2012, Dev. Cell 23(1): 97--111 Two forkhead transcription factors regulate the division of cardiac progenitor cells by a polo-dependent pathway. [FBrf0218973] Amodio et al., 2012, Dev. Dyn. 241(1): 190--199 Transactivation in Drosophila of human enhancers by human transcription factors involved in congenital heart diseases. [FBrf0216960] Fuda et al., 2012, Mol. Cell. Biol. 32(17): 3428--3437 Fcp1 Dephosphorylation of the RNA Polymerase II C-Terminal Domain Is Required for Efficient Transcription of Heat Shock Genes. [FBrf0219151] Hironaka et al., 2012, J. Theor. Biol. 292: 18--29 Multiple feedback loops achieve robust localization of wingless expression in Drosophila notum development. [FBrf0216667] Holmqvist et al., 2012, PLoS Genet. 8(6): e1002769 Preferential Genome Targeting of the CBP Co-Activator by Rel and Smad Proteins in Early Drosophila melanogaster Embryos. [FBrf0218675] Junion et al., 2012, Cell 148(3): 473--486 A transcription factor collective defines cardiac cell fate and reflects lineage history. [FBrf0217404] Liang et al., 2012, Development 139(11): 1956--1964 Response to the BMP gradient requires highly combinatorial inputs from multiple patterning systems in the Drosophila embryo. [FBrf0218213] Rogers and Hartl, 2012, Mol. Biol. Evol. 29(2): 517--529 Chimeric Genes as a Source of Rapid Evolution in Drosophila melanogaster. [FBrf0217452] Tie et al., 2012, Mol. Cell. Biol. 32(12): 2323--2334 Histone Demethylase UTX and Chromatin Remodeler BRM Bind Directly to CBP and Modulate Acetylation of Histone H3 Lysine 27. [FBrf0218406] Valadez-Graham et al., 2012, Nucleic Acids Res. 40(4): 1460--1474 XNP/dATRX interacts with DREF in the chromatin to regulate gene expression. [FBrf0217551] Yang et al., 2012, Development 139(2): 325--334 The kinase Sgg modulates temporal development of macrochaetes in Drosophila by phosphorylation of Scute and Pannier. [FBrf0216991] Zeng et al., 2012, Nucleic Acids Res. 40(13): 5848--5863 Genome-wide polycomb target gene prediction in Drosophila melanogaster. [FBrf0218974] Bantignies et al., 2011, Cell 144(2): 214--226 Polycomb-Dependent Regulatory Contacts between Distant Hox Loci in Drosophila. [FBrf0212775] Cherbas et al., 2011, Genome Res. 21(2): 301--314 The transcriptional diversity of 25 Drosophila cell lines. [FBrf0213077] Gabilondo et al., 2011, Mech. Dev. 128(3-4): 208--221 A targeted genetic screen identifies crucial players in the specification of the Drosophila abdominal Capaergic neurons. [FBrf0213290] Minakhina et al., 2011, Dev. Biol. 352(2): 308--316 JAK/STAT and the GATA factor Pannier control hemocyte maturation and differentiation in Drosophila. [FBrf0213300] Ryu et al., 2011, Dev. Dyn. 240(1): 86--96 Tinman is a direct activator of midline in the drosophila dorsal vessel. [FBrf0212547] Weake et al., 2011, Genes Dev. 25(14): 1499--1509 Post-transcription initiation function of the ubiquitous SAGA complex in tissue-specific gene activation. [FBrf0214372] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2011 Show reviews ...