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Gene Dmel\pnt

General Information
Symbol	Dmel\pnt	Species	D. melanogaster
Name	pointed	Annotation symbol	CG17077
Feature type	protein_coding_gene	FlyBase ID	FBgn0003118
Gene Model Status	Current	Stock availability	46 publicly available
Also Known As	PNTP2, D-ets-2, PNTP1, PNT-P1, DMPOINT1A
Genomic Location
Chromosome (arm)	3R	Recombination map	3-79.0
Cytogenetic map	94E9-94E13	Sequence location	3R:19,115,953..19,171,889 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene pointed is referred to in FlyBase by the symbol Dmel\pnt (CG17077, FBgn0003118). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: protein binding; sequence-specific DNA binding RNA polymerase II transcription factor activity; RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription; repressing transcription factor binding. There is experimental evidence for 22 unique biological process terms, many of which group under: single-organism developmental process; biological regulation; open tracheal system development; post-embryonic organ morphogenesis; regulation of developmental process; localization; positive regulation of cell proliferation; cellular component organization or biogenesis; anterior/posterior axis specification; sensory organ development; muscle cell differentiation; regulation of neurogenesis. 119 alleles are reported. The phenotypes of these alleles are annotated with: organ system subdivision; organ system; larval abdominal segment; external compound sense organ; non-connected developing system; late extended germ band embryo; peripheral nervous system; adult segment; thoracic segment; imaginal precursor. It has 4 annotated transcripts and 4 annotated polypeptides. Protein features are: Ets domain; Pointed domain; Sterile alpha motif/pointed domain; Winged helix-turn-helix transcription repressor DNA-binding domain. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of low expression. Peak expression observed within 00-12 hour embryonic stages. Summary of FlyAtlas Anatomical Expression Data: Little or no expression detected in any larval or adult organs/tissues. Comments on Affy2 ProbeSet: ProbeSet 1630010_a_at completely aligns to an exonic region common to each of the 3 FlyBase-annotated transcript isoforms of pnt. Gene sequence location is 3R:19115953..19171889.
User Contributed Data
	Beta version, feedback welcome
External Summaries
Phenotypic Description from the Red Book (Lindsley & Zimm 1992)
Gene/Allele symbols may differ from current usage	Ets2: Ets-2 proto-oncogene homologue Encodes a Drosophila homologue to the ets gene from the avian erythroblastosis retrovirus E26. mRNA constitutively present in all developmental stages, with elevated levels of expression in 0-9-hr embryos and pupae. pnt: pointed Homozygous lethal. Zygotic expression in embryo. Head skeleton of embryo pointed; median part of all denticle bands deleted. CNS broad and less dense than wild type. Sensory organs (maxillary, antennal, and Keilin's organs) spread.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2013_03	Alleles pnt[MI07710] Controlled Vocabulary Terms trachea development
FB2013_02	Controlled Vocabulary Terms embryonic/larval optic lobe neuroblast
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 94E9-94E13   Limits computationally determined from genome sequence between P{PZ}cnc03921 and P{PZ}l(3)0690606906
Experimentally Determined Cytological Location
Cytogenetic map Notes References 94F1-94F2   (determined by in situ hybridisation)   (Spradling et al., 1999) 94F-94F   (determined by in situ hybridisation)   (Szeged Stock Center, 1998-) 94F1-94F3   (determined by in situ hybridisation)   (Salzberg et al., 1997) 94F1-94F3   (determined by in situ hybridisation) 94F (determined by in situ hybridisation)   (Deak et al., 1997) 94F-94F   (determined by in situ hybridisation)   (Forjanic et al., 1997) 64A4-64A5   68C12--13 94F1--3   (BDGP Project Members, 1994-1999) 94E-94F   (determined by in situ hybridisation)   (Klambt, 1991) 58A-58B   (determined by in situ hybridisation)   (Pribyl et al., 1988) 94F-94F   Cytological location differs from that reported in FBrf0047835. It is based upon hybridisation with two independent cDNA clones. (determined by in situ hybridisation)   (Chen et al., 1992)
Experimentally Determined Recombination Data
Location	3-79.0   3-79 (Tearle and Nusslein-Volhard, 1987)
Left of (cM)
Right of (cM)	e (Staehling-Hampton et al., 1999)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\pnt for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.47 Low-frequency RNA-Seq exon junction(s) not annotated.
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) pnt-RB FBtr0089717  NM_079737   4074   718 pnt-RC FBtr0089715  NM_170070   2996   623 pnt-RD FBtr0089716  NM_170651   2805   636 pnt-RE FBtr0334554  NM_001275943   3715   625
Additional Transcript Data & Comments
Reported size (kB)	4.7 (northern blot) (Pribyl et al., 1988) 4.4 (northern blot) (Chen et al., 1992) 4.2, 4.0 (northern blot) (Klambt, 1993)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein pnt-PB   FBpp0088658   77.7   718   6.60     NP_524461   AAF56125 pnt-PC   FBpp0088656   66.9   623   6.72     NP_732858   AAN13943 pnt-PD   FBpp0088657   69.9   636   6.69     NP_732857   AAN13942 pnt-PE   FBpp0306621   67.0   625   6.72     NP_001262872   AGB96252
Additional Polypeptide Data & Comments
Reported size (kDa)	718, 623 (aa); 78, 67 (kD predicted) (Klambt, 1993)
Comments	The P2 pnt protein, which has a single MAP kinase phosphorylation site motif, is phosphorylated by rl MAP kinase in vitro. (Brunner et al., 1994) The amino acid sequences of various Ets98B gene family members were studied to determine evolutionary relatedness. Phylogenetic trees were derived. (Lautenberger et al., 1992)
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Ets domain (IPR000418) Pointed domain (IPR003118) Winged helix-turn-helix DNA-binding domain (IPR011991) Sterile alpha motif/pointed domain (IPR013761)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA264939   AE014297 AAF56125   AE014297 AAN13942   AE014297 AAN13943   AF067896   AE014297 AGB96252   AI106968   AI531515   AI531826   AI531847   AI532024   AI532292   AI532709   AI533875   AI534222   AI534281   AI542908   AI542918   AI543583   AY863885   AY863886   AY863887   AY863888   AY863889   AY863890   AY863891   AY863892   AY863893   AY863894   AY863895   AY863896   AY863897   AY863898   AY863899   AY863900   AY863901   AY863902   AY863903   AY863904   AY863905   AY863906   BG637476   BG637914   BG640387   BH740840   BI141777   BI213191   BI230419   BI481771   BI575934   BI580063   BI608635   BI609512   BI621805   BI631528   BI632462   BI632620   BI632880   BI635423   BI635658   BI636577   BI636870   BI637963   BI639699   BI640912   BT001893 AAN71682   BT011152   BT024187   BT058033   BT133301   CL610132   CO152902   CO156874   CO190532   CO274869   CO292658   CO295588   CO297669   CO306779   CO314248   CO318393   CO318480   CO323314   CO333657   CO336549   CO336827   CO337364   CO338521   CZ466575   CZ471367   CZ471505   CZ471506   CZ472220   CZ473108   CZ475553   CZ475577   CZ475979   CZ484052   CZ484053   DU708663   EC051128   EC051207   EC051722   EC052670   EC053162   EC054645   EC055394   EC056635   EC059927   EC061170   EC065909   EC067527   EC072537   EC075482   EC076762   EC078296   EC194574   EC204323   EC205406   EC241417   EC246506   EC248216   EC249753   EC260803   EC262380   EC264910   EC265186   EC266012   EC266236   EL881551   ES691042   G00471   GH945752   GH946782   M20408 AAA28521   M88472 AAC34200   X69166 CAA48916   X69167 CAA48917
UniProtKB/Swiss-Prot	P51022 P51023
UniProtKB/TrEMBL
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References regulatory region FBsf0000435231 3R:19,167,526..19,169,991 evidence=Reporter construct (in vivo) (Sandmann et al., 2006, Halfon, 2012.6.19) regulatory region FBsf0000435978 3R:19,169,303..19,169,916 evidence=Reporter construct (in vivo) (Junion et al., 2012, Halfon, 2012.6.19)
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage   maxillary segment   (Klambt, 1993) labial segment   (Klambt, 1993) mandibular segment   (Klambt, 1993) lateral ventral neurectoderm   (Klambt, 1993) embryonic stage | early   organism | 100% egg length   (Klambt, 1993) Comment:99-100% egg length embryonic stage 1 -- 3   organism   (Fisher et al., 2012) Comment:maternally deposited embryonic stage 4 -- 5   organism | anterior & dorsal   (Chen et al., 1992) Comment:dorsal anterior tip of embryo embryonic stage 4 -- 6   central brain anlage in statu nascendi   (Fisher et al., 2012) foregut anlage in statu nascendi   (Fisher et al., 2012) organism | ubiquitous   (Fisher et al., 2012) antennal anlage in statu nascendi   (Fisher et al., 2012) Comment:reported as procephalic ectoderm anlage in statu nascendi dorsal head epidermis anlage in statu nascendi   (Fisher et al., 2012) Comment:reported as procephalic ectoderm anlage in statu nascendi visual anlage in statu nascendi   (Fisher et al., 2012) Comment:reported as procephalic ectoderm anlage in statu nascendi embryonic stage 6 -- 12   mesoderm   (Klambt, 1993) embryonic stage 7 -- 8   ventral neurectoderm | restricted   (Chen et al., 1992) anterior endoderm   (Chen et al., 1992) antennal anlage   (Fisher et al., 2012) Comment:reported as procephalic ectoderm anlage central brain anlage   (Fisher et al., 2012) Comment:reported as procephalic ectoderm anlage dorsal head epidermis anlage   (Fisher et al., 2012) Comment:reported as procephalic ectoderm anlage visual anlage   (Fisher et al., 2012) Comment:reported as procephalic ectoderm anlage clypeo-labral anlage   (Fisher et al., 2012) foregut anlage   (Fisher et al., 2012) organism | ubiquitous   (Fisher et al., 2012) ventral ectoderm   (Fisher et al., 2012) embryonic stage 9 -- 10   ventral ectoderm | restricted & segmentally repeated   (Wessells et al., 1999) Comment:1-2 cells/hemisegment ventral midline | restricted & segmentally repeated   (Wessells et al., 1999) Comment:1-2 cells/hemisegment antennal primordium   (Fisher et al., 2012) Comment:reported as procephalic ectoderm primordium central brain primordium   (Fisher et al., 2012) Comment:reported as procephalic ectoderm primordium visual primordium   (Fisher et al., 2012) Comment:reported as procephalic ectoderm primordium dorsal head epidermis primordium   (Fisher et al., 2012) Comment:reported as procephalic ectoderm primordium lateral head epidermis primordium   (Fisher et al., 2012) Comment:reported as procephalic ectoderm primordium ventral head epidermis primordium   (Fisher et al., 2012) Comment:reported as procephalic ectoderm primordium clypeo-labral primordium   (Fisher et al., 2012) dorsal ectoderm   (Fisher et al., 2012) foregut primordium   (Fisher et al., 2012) organism | segmentally repeated   (Fisher et al., 2012) organism | ubiquitous   (Fisher et al., 2012) trunk mesoderm   (Fisher et al., 2012) ventral ectoderm   (Fisher et al., 2012) embryonic stage 10 -- 11   mesoderm   (Chen et al., 1992) parasegmental furrow | anterior to   (Chen et al., 1992) embryonic stage 11   ventral ectoderm   (Chang et al., 2000) embryonic stage 11 -- 12   antennal primordium   (Fisher et al., 2012) Comment:reported as procephalon primordium central brain primordium   (Fisher et al., 2012) Comment:reported as procephalon primordium dorsal head epidermis primordium   (Fisher et al., 2012) Comment:reported as head epidermis primordium lateral head epidermis primordium   (Fisher et al., 2012) Comment:reported as head epidermis primordium ventral head epidermis primordium   (Fisher et al., 2012) Comment:reported as head epidermis primordium visual primordium   (Fisher et al., 2012) Comment:reported as procephalon primordium clypeo-labral primordium   (Fisher et al., 2012) dorsal epidermis primordium   (Fisher et al., 2012) foregut primordium   (Fisher et al., 2012) hindgut proper primordium   (Fisher et al., 2012) organism | segmentally repeated   (Fisher et al., 2012) organism | ubiquitous   (Fisher et al., 2012) trunk mesoderm   (Fisher et al., 2012) ventral epidermis primordium   (Fisher et al., 2012) ventral nerve cord primordium   (Fisher et al., 2012) embryonic stage 11 -- 17   embryonic/larval tracheal system   (Klambt, 1993) embryonic stage 12 -- 13   imaginal disc primordium   (Scholz et al., 1993) midline glial cell   (Scholz et al., 1993) mesoderm   (Scholz et al., 1993) organism | restricted & segmentally repeated   (Chen et al., 1992) Comment:complex pattern embryonic stage 12 -- 14   VUM neuron   (Klambt, 1993) interface glial cell   (Klambt, 1993) embryonic stage 13 -- 16   embryonic brain   (Fisher et al., 2012) embryonic dorsal epidermis   (Fisher et al., 2012) embryonic esophagus   (Fisher et al., 2012) embryonic head epidermis   (Fisher et al., 2012) embryonic hindgut   (Fisher et al., 2012) embryonic proventriculus   (Fisher et al., 2012) embryonic/larval circulatory system   (Fisher et al., 2012) embryonic/larval muscle system   (Fisher et al., 2012) labral segment   (Fisher et al., 2012) longitudinal visceral muscle fiber   (Fisher et al., 2012) organism | faint & ubiquitous   (Fisher et al., 2012) ventral nerve cord   (Fisher et al., 2012) larval stage   morphogenetic furrow   (Brunner et al., 1994) morphogenetic furrow | posterior to   (Brunner et al., 1994) third instar larval stage   ommatidium | restricted   (Rawlins et al., 2003) northern blot Stage Tissue/Position (including subcellular localization) Reference embryonic stage -- adult stage   organism   (Chen et al., 1992)
Additional Descriptive Data
	Transcript is expressed in the intermediate groups and R8 photoreceptor equivalence groups of the developing retina. (Rawlins et al., 2003)
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
immunolocalization Stage Tissue/Position (including subcellular localization) Reference larval stage   ommatidium | precursor   (Brunner et al., 1994) morphogenetic furrow | subset   (Brunner et al., 1994) third instar larval stage   neuroblast of embryonic/larval optic lobe   (Weng et al., 2012)
Additional Descriptive Data
	With an antibody that detects both pnt protein isoforms, pnt protein is detected in the nuclei of ommatidial precursor cells. In a background that is mutant for the 718 amino acid P2 isoform, most all nuclear staining is eliminated, except for clusters of nuclei in the morphogenetic furrow, and scattered nuclei in the posterior part of the eye. This staining presumably corresponds to the P1 isoform, and is in good agreement with the distribution of the P1 transcript. In photoreceptor precursors, the appearance of pnt P2 protein precedes the appearance of elav protein, and after about 4-6 hours of co-expression, pnt P2 protein is no longer detected. (Brunner et al., 1994) With an antibody that detects both pnt protein isoforms, pnt protein is detected in the nuclei of ommatidial precursor cells. In a background that is mutant for the 718 amino acid P2 isoform, most all nuclear staining is eliminated, except for clusters of nuclei in the morphogenetic furrow, and scattered nuclei in the posterior part of the eye. This staining presumably corresponds to the P1 isoform, and is in good agreement with the distribution of the P1 transcript. (Brunner et al., 1994)
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
nucleus inferred from direct assay (Brunner et al., 1994)
Expression Deduced from Reporters
Reporter: P{A92}pntrM254 Stage Tissue/Position (including subcellular localization) Reference embryonic stage | late   A-subperineurial glial cell   (Klaes et al., 1994) B-subperineurial glial cell of abdomen   (Klaes et al., 1994) interface glial cell   (Klaes et al., 1994) medial intersegmental nerve root glial cell   (Klaes et al., 1994) glial cell of VUM neuron   (Klaes et al., 1994) Reporter: P{lacW}pnt1277 Stage Tissue/Position (including subcellular localization) Reference embryonic stage | late   midline glial cell   (Klaes et al., 1994) embryonic stage 11   embryonic/larval oenocyte precursor   (Elstob et al., 2001) C1 chordotonal organ precursor cell   (Elstob et al., 2001) pupal stage P6   epithelial cell | subset of leg   (Peng et al., 2012) Comment:20-24h APF pupal stage P6 -- P7   bract primordium | subset of leg | intense   (Peng et al., 2012) Comment:28-40h APF epithelial cell | subset of leg | faint   (Peng et al., 2012) Comment:28-40h APF Reporter: P{lacW}pntS060807a Stage Tissue/Position (including subcellular localization) Reference embryonic stage     (Salzberg et al., 1997) Reporter: P{lacW}pntS099812 Stage Tissue/Position (including subcellular localization) Reference embryonic stage   embryonic/larval heart   (Salzberg et al., 1997) embryonic/larval midgut | restricted   (Salzberg et al., 1997) Reporter: P{PZ}pnt07825 Stage Tissue/Position (including subcellular localization) Reference embryonic stage 10 -- 17   Malpighian tubule | restricted   (Kerber et al., 1998) embryonic stage 12 -- 17   embryonic/larval tracheal system | restricted   (Samakovlis et al., 1996) wandering third instar larval stage   imaginal disc   (Meister and Braun, 1995.10) Malpighian tubule | restricted   (Meister and Braun, 1995.10) adult stage   lamina   (Vosshall, 1998.8.10)
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Little or no expression detected in any larval or adult organs/tissues. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    68.625 Larval Midgut    47.4 Larval Hindgut    26.7 Larval Malpighian Tubules    23 Larval Fat Body    18.2 Larval Salivary Gland    4.8 Larval Trachea    43.25 Larval Carcass    21.925 Adult Head    21.9 Adult Eye    20.65 Adult Brain    19 Adult Thoracic-Abdominal Ganglion    21.6 Adult Crop    59 Adult Midgut    42.8 Adult Hindgut    15.1 Adult Malpighian Tubules    24.3 Adult Fat Body    14.8 Adult Salivary Gland    6.3 Adult Heart    75.075 Adult VirginFemale Spermatheca    9.8 Adult InseminatedFemale Spermatheca    10.4 Adult Ovary    13 Adult Testis    4.4 Adult Male Accessory Gland    17.6 Adult Carcass    18.1 Expression Level Scale  None   Low  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    68.625 Larval Midgut    47.4 Larval Hindgut    26.7 Larval Malpighian Tubules    23 Larval Fat Body    18.2 Larval Salivary Gland    4.8 Larval Trachea    43.25 Larval Carcass    21.925 Adult Head    21.9 Adult Eye    20.65 Adult Brain    19 Adult Thoracic-Abdominal Ganglion    21.6 Adult Crop    59 Adult Midgut    42.8 Adult Hindgut    15.1 Adult Malpighian Tubules    24.3 Adult Fat Body    14.8 Adult Salivary Gland    6.3 Adult Heart    75.075 Adult VirginFemale Spermatheca    9.8 Adult InseminatedFemale Spermatheca    10.4 Adult Ovary    13 Adult Testis    4.4 Adult Male Accessory Gland    17.6 Adult Carcass    18.1 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    68.625 Larval Midgut    47.4 Larval Hindgut    26.7 Larval Malpighian Tubules    23 Larval Fat Body    18.2 Larval Salivary Gland    4.8 Larval Trachea    43.25 Larval Carcass    21.925 Adult Head    21.9 Adult Eye    20.65 Adult Brain    19 Adult Thoracic-Abdominal Ganglion    21.6 Adult Crop    59 Adult Midgut    42.8 Adult Hindgut    15.1 Adult Malpighian Tubules    24.3 Adult Fat Body    14.8 Adult Salivary Gland    6.3 Adult Heart    75.075 Adult VirginFemale Spermatheca    9.8 Adult InseminatedFemale Spermatheca    10.4 Adult Ovary    13 Adult Testis    4.4 Adult Male Accessory Gland    17.6 Adult Carcass    18.1 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    68.625 Larval Midgut    47.4 Larval Hindgut    26.7 Larval Malpighian Tubules    23 Larval Fat Body    18.2 Larval Salivary Gland    4.8 Larval Trachea    43.25 Larval Carcass    21.925 Adult Head    21.9 Adult Eye    20.65 Adult Brain    19 Adult Thoracic-Abdominal Ganglion    21.6 Adult Crop    59 Adult Midgut    42.8 Adult Hindgut    15.1 Adult Malpighian Tubules    24.3 Adult Fat Body    14.8 Adult Salivary Gland    6.3 Adult Heart    75.075 Adult VirginFemale Spermatheca    9.8 Adult InseminatedFemale Spermatheca    10.4 Adult Ovary    13 Adult Testis    4.4 Adult Male Accessory Gland    17.6 Adult Carcass    18.1 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    68.625 Larval Midgut    47.4 Larval Hindgut    26.7 Larval Malpighian Tubules    23 Larval Fat Body    18.2 Larval Salivary Gland    4.8 Larval Trachea    43.25 Larval Carcass    21.925 Adult Head    21.9 Adult Eye    20.65 Adult Brain    19 Adult Thoracic-Abdominal Ganglion    21.6 Adult Crop    59 Adult Midgut    42.8 Adult Hindgut    15.1 Adult Malpighian Tubules    24.3 Adult Fat Body    14.8 Adult Salivary Gland    6.3 Adult Heart    75.075 Adult VirginFemale Spermatheca    9.8 Adult InseminatedFemale Spermatheca    10.4 Adult Ovary    13 Adult Testis    4.4 Adult Male Accessory Gland    17.6 Adult Carcass    18.1 Expression Level Scale  None   Low   Moderate  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    68.625 Larval Midgut    47.4 Larval Hindgut    26.7 Larval Malpighian Tubules    23 Larval Fat Body    18.2 Larval Salivary Gland    4.8 Larval Trachea    43.25 Larval Carcass    21.925 Adult Head    21.9 Adult Eye    20.65 Adult Brain    19 Adult Thoracic-Abdominal Ganglion    21.6 Adult Crop    59 Adult Midgut    42.8 Adult Hindgut    15.1 Adult Malpighian Tubules    24.3 Adult Fat Body    14.8 Adult Salivary Gland    6.3 Adult Heart    75.075 Adult VirginFemale Spermatheca    9.8 Adult InseminatedFemale Spermatheca    10.4 Adult Ovary    13 Adult Testis    4.4 Adult Male Accessory Gland    17.6 Adult Carcass    18.1 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    68.625 Larval Midgut    47.4 Larval Hindgut    26.7 Larval Malpighian Tubules    23 Larval Fat Body    18.2 Larval Salivary Gland    4.8 Larval Trachea    43.25 Larval Carcass    21.925 Adult Head    21.9 Adult Eye    20.65 Adult Brain    19 Adult Thoracic-Abdominal Ganglion    21.6 Adult Crop    59 Adult Midgut    42.8 Adult Hindgut    15.1 Adult Malpighian Tubules    24.3 Adult Fat Body    14.8 Adult Salivary Gland    6.3 Adult Heart    75.075 Adult VirginFemale Spermatheca    9.8 Adult InseminatedFemale Spermatheca    10.4 Adult Ovary    13 Adult Testis    4.4 Adult Male Accessory Gland    17.6 Adult Carcass    18.1 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    68.625 Larval Midgut    47.4 Larval Hindgut    26.7 Larval Malpighian Tubules    23 Larval Fat Body    18.2 Larval Salivary Gland    4.8 Larval Trachea    43.25 Larval Carcass    21.925 Adult Head    21.9 Adult Eye    20.65 Adult Brain    19 Adult Thoracic-Abdominal Ganglion    21.6 Adult Crop    59 Adult Midgut    42.8 Adult Hindgut    15.1 Adult Malpighian Tubules    24.3 Adult Fat Body    14.8 Adult Salivary Gland    6.3 Adult Heart    75.075 Adult VirginFemale Spermatheca    9.8 Adult InseminatedFemale Spermatheca    10.4 Adult Ovary    13 Adult Testis    4.4 Adult Male Accessory Gland    17.6 Adult Carcass    18.1 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    21.9   NA  Eye    20.65   NA  Brain    19   68.625  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    21.6   NA  Crop    59   47.4  Midgut    42.8   26.7  Hindgut    15.1   23  Malpighian Tubules    no informative data   no informative data  Fat Body    14.8   4.8  Salivary Gland    6.3   NA  Heart    75.075   43.25  Trachea    NA   NA  VirginFemale Spermatheca    9.8   NA  InseminatedFemale Spermatheca    no informative data   NA  Ovary    13   NA  Testis    4.4   NA  Male Accessory Gland    no informative data   21.925  Carcass    18.1 FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    6 central nervous system, larvae L3    7 central nervous system, pupae P8    3 head, virgin 1-day female    2 head, virgin 4-day female    3 head, virgin 20-day female    2 head, mated 1-day female    3 head, mated 4-day female    2 head, mated 20-day female    2 head, mated 1-day male    3 head, mated 4-day male    2 head, mated 20-day male    4 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    10 digestive system, 1-day adult    3 digestive system, 4-day adult    5 digestive system, 20-day adult    6 fat body, larvae L3 wandering    2 fat body, white prepupae    2 fat body, pupae P8    5 carcass, larvae L3 wandering    5 carcass, 1-day adult    2 carcass, 4-day adult    2 carcass, 20-day adult    2 ovary, virgin 4-day female    4 ovary, mated 4-day female    3 testis, mated 4-day male    0 accessory gland, mated 4-day male    1 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    6 central nervous system, larvae L3    7 central nervous system, pupae P8    3 head, virgin 1-day female    2 head, virgin 4-day female    3 head, virgin 20-day female    2 head, mated 1-day female    3 head, mated 4-day female    2 head, mated 20-day female    2 head, mated 1-day male    3 head, mated 4-day male    2 head, mated 20-day male    4 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    10 digestive system, 1-day adult    3 digestive system, 4-day adult    5 digestive system, 20-day adult    6 fat body, larvae L3 wandering    2 fat body, white prepupae    2 fat body, pupae P8    5 carcass, larvae L3 wandering    5 carcass, 1-day adult    2 carcass, 4-day adult    2 carcass, 20-day adult    2 ovary, virgin 4-day female    4 ovary, mated 4-day female    3 testis, mated 4-day male    0 accessory gland, mated 4-day male    1 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    6 central nervous system, larvae L3    7 central nervous system, pupae P8    3 head, virgin 1-day female    2 head, virgin 4-day female    3 head, virgin 20-day female    2 head, mated 1-day female    3 head, mated 4-day female    2 head, mated 20-day female    2 head, mated 1-day male    3 head, mated 4-day male    2 head, mated 20-day male    4 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    10 digestive system, 1-day adult    3 digestive system, 4-day adult    5 digestive system, 20-day adult    6 fat body, larvae L3 wandering    2 fat body, white prepupae    2 fat body, pupae P8    5 carcass, larvae L3 wandering    5 carcass, 1-day adult    2 carcass, 4-day adult    2 carcass, 20-day adult    2 ovary, virgin 4-day female    4 ovary, mated 4-day female    3 testis, mated 4-day male    0 accessory gland, mated 4-day male    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    6 central nervous system, larvae L3    7 central nervous system, pupae P8    3 head, virgin 1-day female    2 head, virgin 4-day female    3 head, virgin 20-day female    2 head, mated 1-day female    3 head, mated 4-day female    2 head, mated 20-day female    2 head, mated 1-day male    3 head, mated 4-day male    2 head, mated 20-day male    4 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    10 digestive system, 1-day adult    3 digestive system, 4-day adult    5 digestive system, 20-day adult    6 fat body, larvae L3 wandering    2 fat body, white prepupae    2 fat body, pupae P8    5 carcass, larvae L3 wandering    5 carcass, 1-day adult    2 carcass, 4-day adult    2 carcass, 20-day adult    2 ovary, virgin 4-day female    4 ovary, mated 4-day female    3 testis, mated 4-day male    0 accessory gland, mated 4-day male    1 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    6 central nervous system, larvae L3    7 central nervous system, pupae P8    3 head, virgin 1-day female    2 head, virgin 4-day female    3 head, virgin 20-day female    2 head, mated 1-day female    3 head, mated 4-day female    2 head, mated 20-day female    2 head, mated 1-day male    3 head, mated 4-day male    2 head, mated 20-day male    4 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    10 digestive system, 1-day adult    3 digestive system, 4-day adult    5 digestive system, 20-day adult    6 fat body, larvae L3 wandering    2 fat body, white prepupae    2 fat body, pupae P8    5 carcass, larvae L3 wandering    5 carcass, 1-day adult    2 carcass, 4-day adult    2 carcass, 20-day adult    2 ovary, virgin 4-day female    4 ovary, mated 4-day female    3 testis, mated 4-day male    0 accessory gland, mated 4-day male    1 Expression Level Scale  Very low   Low   Moderate  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    6 central nervous system, larvae L3    7 central nervous system, pupae P8    3 head, virgin 1-day female    2 head, virgin 4-day female    3 head, virgin 20-day female    2 head, mated 1-day female    3 head, mated 4-day female    2 head, mated 20-day female    2 head, mated 1-day male    3 head, mated 4-day male    2 head, mated 20-day male    4 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    10 digestive system, 1-day adult    3 digestive system, 4-day adult    5 digestive system, 20-day adult    6 fat body, larvae L3 wandering    2 fat body, white prepupae    2 fat body, pupae P8    5 carcass, larvae L3 wandering    5 carcass, 1-day adult    2 carcass, 4-day adult    2 carcass, 20-day adult    2 ovary, virgin 4-day female    4 ovary, mated 4-day female    3 testis, mated 4-day male    0 accessory gland, mated 4-day male    1 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    6 central nervous system, larvae L3    7 central nervous system, pupae P8    3 head, virgin 1-day female    2 head, virgin 4-day female    3 head, virgin 20-day female    2 head, mated 1-day female    3 head, mated 4-day female    2 head, mated 20-day female    2 head, mated 1-day male    3 head, mated 4-day male    2 head, mated 20-day male    4 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    10 digestive system, 1-day adult    3 digestive system, 4-day adult    5 digestive system, 20-day adult    6 fat body, larvae L3 wandering    2 fat body, white prepupae    2 fat body, pupae P8    5 carcass, larvae L3 wandering    5 carcass, 1-day adult    2 carcass, 4-day adult    2 carcass, 20-day adult    2 ovary, virgin 4-day female    4 ovary, mated 4-day female    3 testis, mated 4-day male    0 accessory gland, mated 4-day male    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    6 central nervous system, larvae L3    7 central nervous system, pupae P8    3 head, virgin 1-day female    2 head, virgin 4-day female    3 head, virgin 20-day female    2 head, mated 1-day female    3 head, mated 4-day female    2 head, mated 20-day female    2 head, mated 1-day male    3 head, mated 4-day male    2 head, mated 20-day male    4 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    10 digestive system, 1-day adult    3 digestive system, 4-day adult    5 digestive system, 20-day adult    6 fat body, larvae L3 wandering    2 fat body, white prepupae    2 fat body, pupae P8    5 carcass, larvae L3 wandering    5 carcass, 1-day adult    2 carcass, 4-day adult    2 carcass, 20-day adult    2 ovary, virgin 4-day female    4 ovary, mated 4-day female    3 testis, mated 4-day male    0 accessory gland, mated 4-day male    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of low expression. Peak expression observed within 00-12 hour embryonic stages. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    2 embryo 02-04hr    8 embryo 04-06hr    25 embryo 06-08hr    35 embryo 08-10hr    24 embryo 10-12hr    15 embryo 12-14hr    16 embryo 14-16hr    9 embryo 16-18hr    10 embryo 18-20hr    11 embryo 20-22hr    11 embryo 22-24hr    13 larva L1    6 larva L2    4 larva L3 12hr old    4 larva L3 puffstage 1-2    4 larva L3 puffstage 3-6    6 larva L3 puffstage 7-9    5 white prepupae new    5 white prepupae 12hr    6 white prepupae 24hr    9 pupae 2d postWPP    8 pupae 3d postWPP    7 pupae 4d postWPP    3 adult male 01day    4 adult male 05day    3 adult male 30day    3 adult female 01day    4 adult female 05day    4 adult female 30day    4 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    2 embryo 02-04hr    8 embryo 04-06hr    25 embryo 06-08hr  (35) embryo 08-10hr    24 embryo 10-12hr    15 embryo 12-14hr    16 embryo 14-16hr    9 embryo 16-18hr    10 embryo 18-20hr    11 embryo 20-22hr    11 embryo 22-24hr    13 larva L1    6 larva L2    4 larva L3 12hr old    4 larva L3 puffstage 1-2    4 larva L3 puffstage 3-6    6 larva L3 puffstage 7-9    5 white prepupae new    5 white prepupae 12hr    6 white prepupae 24hr    9 pupae 2d postWPP    8 pupae 3d postWPP    7 pupae 4d postWPP    3 adult male 01day    4 adult male 05day    3 adult male 30day    3 adult female 01day    4 adult female 05day    4 adult female 30day    4 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    2 embryo 02-04hr    8 embryo 04-06hr    25 embryo 06-08hr    35 embryo 08-10hr    24 embryo 10-12hr    15 embryo 12-14hr    16 embryo 14-16hr    9 embryo 16-18hr    10 embryo 18-20hr    11 embryo 20-22hr    11 embryo 22-24hr    13 larva L1    6 larva L2    4 larva L3 12hr old    4 larva L3 puffstage 1-2    4 larva L3 puffstage 3-6    6 larva L3 puffstage 7-9    5 white prepupae new    5 white prepupae 12hr    6 white prepupae 24hr    9 pupae 2d postWPP    8 pupae 3d postWPP    7 pupae 4d postWPP    3 adult male 01day    4 adult male 05day    3 adult male 30day    3 adult female 01day    4 adult female 05day    4 adult female 30day    4 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    2 embryo 02-04hr    8 embryo 04-06hr    25 embryo 06-08hr    35 embryo 08-10hr    24 embryo 10-12hr    15 embryo 12-14hr    16 embryo 14-16hr    9 embryo 16-18hr    10 embryo 18-20hr    11 embryo 20-22hr    11 embryo 22-24hr    13 larva L1    6 larva L2    4 larva L3 12hr old    4 larva L3 puffstage 1-2    4 larva L3 puffstage 3-6    6 larva L3 puffstage 7-9    5 white prepupae new    5 white prepupae 12hr    6 white prepupae 24hr    9 pupae 2d postWPP    8 pupae 3d postWPP    7 pupae 4d postWPP    3 adult male 01day    4 adult male 05day    3 adult male 30day    3 adult female 01day    4 adult female 05day    4 adult female 30day    4 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    2 embryo 02-04hr    8 embryo 04-06hr    25 embryo 06-08hr    35 embryo 08-10hr    24 embryo 10-12hr    15 embryo 12-14hr    16 embryo 14-16hr    9 embryo 16-18hr    10 embryo 18-20hr    11 embryo 20-22hr    11 embryo 22-24hr    13 larva L1    6 larva L2    4 larva L3 12hr old    4 larva L3 puffstage 1-2    4 larva L3 puffstage 3-6    6 larva L3 puffstage 7-9    5 white prepupae new    5 white prepupae 12hr    6 white prepupae 24hr    9 pupae 2d postWPP    8 pupae 3d postWPP    7 pupae 4d postWPP    3 adult male 01day    4 adult male 05day    3 adult male 30day    3 adult female 01day    4 adult female 05day    4 adult female 30day    4 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    2 embryo 02-04hr    8 embryo 04-06hr    25 embryo 06-08hr  (35) embryo 08-10hr    24 embryo 10-12hr    15 embryo 12-14hr    16 embryo 14-16hr    9 embryo 16-18hr    10 embryo 18-20hr    11 embryo 20-22hr    11 embryo 22-24hr    13 larva L1    6 larva L2    4 larva L3 12hr old    4 larva L3 puffstage 1-2    4 larva L3 puffstage 3-6    6 larva L3 puffstage 7-9    5 white prepupae new    5 white prepupae 12hr    6 white prepupae 24hr    9 pupae 2d postWPP    8 pupae 3d postWPP    7 pupae 4d postWPP    3 adult male 01day    4 adult male 05day    3 adult male 30day    3 adult female 01day    4 adult female 05day    4 adult female 30day    4 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    2 embryo 02-04hr    8 embryo 04-06hr    25 embryo 06-08hr    35 embryo 08-10hr    24 embryo 10-12hr    15 embryo 12-14hr    16 embryo 14-16hr    9 embryo 16-18hr    10 embryo 18-20hr    11 embryo 20-22hr    11 embryo 22-24hr    13 larva L1    6 larva L2    4 larva L3 12hr old    4 larva L3 puffstage 1-2    4 larva L3 puffstage 3-6    6 larva L3 puffstage 7-9    5 white prepupae new    5 white prepupae 12hr    6 white prepupae 24hr    9 pupae 2d postWPP    8 pupae 3d postWPP    7 pupae 4d postWPP    3 adult male 01day    4 adult male 05day    3 adult male 30day    3 adult female 01day    4 adult female 05day    4 adult female 30day    4 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    2 embryo 02-04hr    8 embryo 04-06hr    25 embryo 06-08hr    35 embryo 08-10hr    24 embryo 10-12hr    15 embryo 12-14hr    16 embryo 14-16hr    9 embryo 16-18hr    10 embryo 18-20hr    11 embryo 20-22hr    11 embryo 22-24hr    13 larva L1    6 larva L2    4 larva L3 12hr old    4 larva L3 puffstage 1-2    4 larva L3 puffstage 3-6    6 larva L3 puffstage 7-9    5 white prepupae new    5 white prepupae 12hr    6 white prepupae 24hr    9 pupae 2d postWPP    8 pupae 3d postWPP    7 pupae 4d postWPP    3 adult male 01day    4 adult male 05day    3 adult male 30day    3 adult female 01day    4 adult female 05day    4 adult female 30day    4 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    102 Schneider line 2 Sg4    50 embryonic 1182-4H    52 embryonic GM2    71 embryonic Kc167    51 embryonic S1    24 embryonic S3    61 leg disc CME L1    48 wing disc CME-W2    57 wing disc ML-DmD8    69 wing disc ML-DmD9    74 wing disc ML-DmD16-c3    70 wing disc ML-DmD21    29 wing disc ML-DmD32    67 haltere disc ML-DmD17-c3    53 eye-antennal disc ML-DmD11    37 antennal disc ML-DmD20-c5    34 mixed discs ML-DmD4-c1    31 CNS ML-DmBG1-c1    39 CNS ML-DmBG2-c2    41 tumorous blood cells mbn2    52 ovary fGS/OSS    2 ovary OSC    2 ovary OSS    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (102) Schneider line 2 Sg4  (50) embryonic 1182-4H  (52) embryonic GM2  (71) embryonic Kc167  (51) embryonic S1    24 embryonic S3  (61) leg disc CME L1  (48) wing disc CME-W2  (57) wing disc ML-DmD8  (69) wing disc ML-DmD9  (74) wing disc ML-DmD16-c3  (70) wing disc ML-DmD21  (29) wing disc ML-DmD32  (67) haltere disc ML-DmD17-c3  (53) eye-antennal disc ML-DmD11  (37) antennal disc ML-DmD20-c5  (34) mixed discs ML-DmD4-c1  (31) CNS ML-DmBG1-c1  (39) CNS ML-DmBG2-c2  (41) tumorous blood cells mbn2  (52) ovary fGS/OSS    2 ovary OSC    2 ovary OSS    1 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+  102 Schneider line 2 Sg4    50 embryonic 1182-4H    52 embryonic GM2    71 embryonic Kc167    51 embryonic S1    24 embryonic S3    61 leg disc CME L1    48 wing disc CME-W2    57 wing disc ML-DmD8    69 wing disc ML-DmD9    74 wing disc ML-DmD16-c3    70 wing disc ML-DmD21    29 wing disc ML-DmD32    67 haltere disc ML-DmD17-c3    53 eye-antennal disc ML-DmD11    37 antennal disc ML-DmD20-c5    34 mixed discs ML-DmD4-c1    31 CNS ML-DmBG1-c1    39 CNS ML-DmBG2-c2    41 tumorous blood cells mbn2    52 ovary fGS/OSS    2 ovary OSC    2 ovary OSS    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    102 Schneider line 2 Sg4    50 embryonic 1182-4H    52 embryonic GM2    71 embryonic Kc167    51 embryonic S1    24 embryonic S3    61 leg disc CME L1    48 wing disc CME-W2    57 wing disc ML-DmD8    69 wing disc ML-DmD9    74 wing disc ML-DmD16-c3    70 wing disc ML-DmD21    29 wing disc ML-DmD32    67 haltere disc ML-DmD17-c3    53 eye-antennal disc ML-DmD11    37 antennal disc ML-DmD20-c5    34 mixed discs ML-DmD4-c1    31 CNS ML-DmBG1-c1    39 CNS ML-DmBG2-c2    41 tumorous blood cells mbn2    52 ovary fGS/OSS    2 ovary OSC    2 ovary OSS    1 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    102 Schneider line 2 Sg4    50 embryonic 1182-4H    52 embryonic GM2    71 embryonic Kc167    51 embryonic S1    24 embryonic S3    61 leg disc CME L1    48 wing disc CME-W2    57 wing disc ML-DmD8    69 wing disc ML-DmD9    74 wing disc ML-DmD16-c3    70 wing disc ML-DmD21    29 wing disc ML-DmD32    67 haltere disc ML-DmD17-c3    53 eye-antennal disc ML-DmD11    37 antennal disc ML-DmD20-c5    34 mixed discs ML-DmD4-c1    31 CNS ML-DmBG1-c1    39 CNS ML-DmBG2-c2    41 tumorous blood cells mbn2    52 ovary fGS/OSS    2 ovary OSC    2 ovary OSS    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (102) Schneider line 2 Sg4  (50) embryonic 1182-4H  (52) embryonic GM2  (71) embryonic Kc167  (51) embryonic S1    24 embryonic S3  (61) leg disc CME L1  (48) wing disc CME-W2  (57) wing disc ML-DmD8  (69) wing disc ML-DmD9  (74) wing disc ML-DmD16-c3  (70) wing disc ML-DmD21  29 wing disc ML-DmD32  (67) haltere disc ML-DmD17-c3  (53) eye-antennal disc ML-DmD11  (37) antennal disc ML-DmD20-c5  (34) mixed discs ML-DmD4-c1  31 CNS ML-DmBG1-c1  (39) CNS ML-DmBG2-c2  (41) tumorous blood cells mbn2  (52) ovary fGS/OSS    2 ovary OSC    2 ovary OSS    1 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+  102 Schneider line 2 Sg4    50 embryonic 1182-4H    52 embryonic GM2    71 embryonic Kc167    51 embryonic S1    24 embryonic S3    61 leg disc CME L1    48 wing disc CME-W2    57 wing disc ML-DmD8    69 wing disc ML-DmD9    74 wing disc ML-DmD16-c3    70 wing disc ML-DmD21    29 wing disc ML-DmD32    67 haltere disc ML-DmD17-c3    53 eye-antennal disc ML-DmD11    37 antennal disc ML-DmD20-c5    34 mixed discs ML-DmD4-c1    31 CNS ML-DmBG1-c1    39 CNS ML-DmBG2-c2    41 tumorous blood cells mbn2    52 ovary fGS/OSS    2 ovary OSC    2 ovary OSS    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    102 Schneider line 2 Sg4    50 embryonic 1182-4H    52 embryonic GM2    71 embryonic Kc167    51 embryonic S1    24 embryonic S3    61 leg disc CME L1    48 wing disc CME-W2    57 wing disc ML-DmD8    69 wing disc ML-DmD9    74 wing disc ML-DmD16-c3    70 wing disc ML-DmD21    29 wing disc ML-DmD32    67 haltere disc ML-DmD17-c3    53 eye-antennal disc ML-DmD11    37 antennal disc ML-DmD20-c5    34 mixed discs ML-DmD4-c1    31 CNS ML-DmBG1-c1    39 CNS ML-DmBG2-c2    41 tumorous blood cells mbn2    52 ovary fGS/OSS    2 ovary OSC    2 ovary OSS    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    2 cold shock, 4-day adult    2 heat shock, 4-day adult    3 Cadmium 50 mM 6 hrs, larvae L3    2 Cadmium 50 mM 12 hrs, larvae L3    3 Cadmium 50 mM 48 hrs, 4-day adult    3 Cadmium 100 mM 48 hrs, 4-day adult    3 Copper 0.5 mM 12 hrs, larvae L3    3 Copper 15 mM 48 hrs, 4-day adult    5 Zinc 5 mM 12 hrs, larvae L3    2 Zinc 4.5 mM 48 hrs, 4-day adult    3 Ethanol 2.5% 3 hrs, larvae L3    3 Ethanol 5% 3 hrs, larvae L3    3 Ethanol 10% 3 hrs, larvae L3    2 Caffeine 1.5 mg/ml 4 hrs, larvae L3    4 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    3 Caffeine 25 mg/ml 48 hrs, 4-day adult    2 Paraquat 5 mM 48 hrs, 4-day adult    3 Paraquat 10 mM 48 hrs, 4-day adult    3 Rotenone 2 μg 12 hrs, larvae L3    3 Rotenone 8 μg 12 hrs, larvae L3    2 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    2 cold shock, 4-day adult    2 heat shock, 4-day adult    3 Cadmium 50 mM 6 hrs, larvae L3    2 Cadmium 50 mM 12 hrs, larvae L3    3 Cadmium 50 mM 48 hrs, 4-day adult    3 Cadmium 100 mM 48 hrs, 4-day adult    3 Copper 0.5 mM 12 hrs, larvae L3    3 Copper 15 mM 48 hrs, 4-day adult    5 Zinc 5 mM 12 hrs, larvae L3    2 Zinc 4.5 mM 48 hrs, 4-day adult    3 Ethanol 2.5% 3 hrs, larvae L3    3 Ethanol 5% 3 hrs, larvae L3    3 Ethanol 10% 3 hrs, larvae L3    2 Caffeine 1.5 mg/ml 4 hrs, larvae L3    4 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    3 Caffeine 25 mg/ml 48 hrs, 4-day adult    2 Paraquat 5 mM 48 hrs, 4-day adult    3 Paraquat 10 mM 48 hrs, 4-day adult    3 Rotenone 2 μg 12 hrs, larvae L3    3 Rotenone 8 μg 12 hrs, larvae L3    2 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    2 cold shock, 4-day adult    2 heat shock, 4-day adult    3 Cadmium 50 mM 6 hrs, larvae L3    2 Cadmium 50 mM 12 hrs, larvae L3    3 Cadmium 50 mM 48 hrs, 4-day adult    3 Cadmium 100 mM 48 hrs, 4-day adult    3 Copper 0.5 mM 12 hrs, larvae L3    3 Copper 15 mM 48 hrs, 4-day adult    5 Zinc 5 mM 12 hrs, larvae L3    2 Zinc 4.5 mM 48 hrs, 4-day adult    3 Ethanol 2.5% 3 hrs, larvae L3    3 Ethanol 5% 3 hrs, larvae L3    3 Ethanol 10% 3 hrs, larvae L3    2 Caffeine 1.5 mg/ml 4 hrs, larvae L3    4 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    3 Caffeine 25 mg/ml 48 hrs, 4-day adult    2 Paraquat 5 mM 48 hrs, 4-day adult    3 Paraquat 10 mM 48 hrs, 4-day adult    3 Rotenone 2 μg 12 hrs, larvae L3    3 Rotenone 8 μg 12 hrs, larvae L3    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    2 cold shock, 4-day adult    2 heat shock, 4-day adult    3 Cadmium 50 mM 6 hrs, larvae L3    2 Cadmium 50 mM 12 hrs, larvae L3    3 Cadmium 50 mM 48 hrs, 4-day adult    3 Cadmium 100 mM 48 hrs, 4-day adult    3 Copper 0.5 mM 12 hrs, larvae L3    3 Copper 15 mM 48 hrs, 4-day adult    5 Zinc 5 mM 12 hrs, larvae L3    2 Zinc 4.5 mM 48 hrs, 4-day adult    3 Ethanol 2.5% 3 hrs, larvae L3    3 Ethanol 5% 3 hrs, larvae L3    3 Ethanol 10% 3 hrs, larvae L3    2 Caffeine 1.5 mg/ml 4 hrs, larvae L3    4 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    3 Caffeine 25 mg/ml 48 hrs, 4-day adult    2 Paraquat 5 mM 48 hrs, 4-day adult    3 Paraquat 10 mM 48 hrs, 4-day adult    3 Rotenone 2 μg 12 hrs, larvae L3    3 Rotenone 8 μg 12 hrs, larvae L3    2 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    2 cold shock, 4-day adult    2 heat shock, 4-day adult    3 Cadmium 50 mM 6 hrs, larvae L3    2 Cadmium 50 mM 12 hrs, larvae L3    3 Cadmium 50 mM 48 hrs, 4-day adult    3 Cadmium 100 mM 48 hrs, 4-day adult    3 Copper 0.5 mM 12 hrs, larvae L3    3 Copper 15 mM 48 hrs, 4-day adult    5 Zinc 5 mM 12 hrs, larvae L3    2 Zinc 4.5 mM 48 hrs, 4-day adult    3 Ethanol 2.5% 3 hrs, larvae L3    3 Ethanol 5% 3 hrs, larvae L3    3 Ethanol 10% 3 hrs, larvae L3    2 Caffeine 1.5 mg/ml 4 hrs, larvae L3    4 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    3 Caffeine 25 mg/ml 48 hrs, 4-day adult    2 Paraquat 5 mM 48 hrs, 4-day adult    3 Paraquat 10 mM 48 hrs, 4-day adult    3 Rotenone 2 μg 12 hrs, larvae L3    3 Rotenone 8 μg 12 hrs, larvae L3    2 Expression Level Scale  Very low   Low   Moderate  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    2 cold shock, 4-day adult    2 heat shock, 4-day adult    3 Cadmium 50 mM 6 hrs, larvae L3    2 Cadmium 50 mM 12 hrs, larvae L3    3 Cadmium 50 mM 48 hrs, 4-day adult    3 Cadmium 100 mM 48 hrs, 4-day adult    3 Copper 0.5 mM 12 hrs, larvae L3    3 Copper 15 mM 48 hrs, 4-day adult    5 Zinc 5 mM 12 hrs, larvae L3    2 Zinc 4.5 mM 48 hrs, 4-day adult    3 Ethanol 2.5% 3 hrs, larvae L3    3 Ethanol 5% 3 hrs, larvae L3    3 Ethanol 10% 3 hrs, larvae L3    2 Caffeine 1.5 mg/ml 4 hrs, larvae L3    4 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    3 Caffeine 25 mg/ml 48 hrs, 4-day adult    2 Paraquat 5 mM 48 hrs, 4-day adult    3 Paraquat 10 mM 48 hrs, 4-day adult    3 Rotenone 2 μg 12 hrs, larvae L3    3 Rotenone 8 μg 12 hrs, larvae L3    2 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    2 cold shock, 4-day adult    2 heat shock, 4-day adult    3 Cadmium 50 mM 6 hrs, larvae L3    2 Cadmium 50 mM 12 hrs, larvae L3    3 Cadmium 50 mM 48 hrs, 4-day adult    3 Cadmium 100 mM 48 hrs, 4-day adult    3 Copper 0.5 mM 12 hrs, larvae L3    3 Copper 15 mM 48 hrs, 4-day adult    5 Zinc 5 mM 12 hrs, larvae L3    2 Zinc 4.5 mM 48 hrs, 4-day adult    3 Ethanol 2.5% 3 hrs, larvae L3    3 Ethanol 5% 3 hrs, larvae L3    3 Ethanol 10% 3 hrs, larvae L3    2 Caffeine 1.5 mg/ml 4 hrs, larvae L3    4 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    3 Caffeine 25 mg/ml 48 hrs, 4-day adult    2 Paraquat 5 mM 48 hrs, 4-day adult    3 Paraquat 10 mM 48 hrs, 4-day adult    3 Rotenone 2 μg 12 hrs, larvae L3    3 Rotenone 8 μg 12 hrs, larvae L3    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    2 cold shock, 4-day adult    2 heat shock, 4-day adult    3 Cadmium 50 mM 6 hrs, larvae L3    2 Cadmium 50 mM 12 hrs, larvae L3    3 Cadmium 50 mM 48 hrs, 4-day adult    3 Cadmium 100 mM 48 hrs, 4-day adult    3 Copper 0.5 mM 12 hrs, larvae L3    3 Copper 15 mM 48 hrs, 4-day adult    5 Zinc 5 mM 12 hrs, larvae L3    2 Zinc 4.5 mM 48 hrs, 4-day adult    3 Ethanol 2.5% 3 hrs, larvae L3    3 Ethanol 5% 3 hrs, larvae L3    3 Ethanol 10% 3 hrs, larvae L3    2 Caffeine 1.5 mg/ml 4 hrs, larvae L3    4 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    3 Caffeine 25 mg/ml 48 hrs, 4-day adult    2 Paraquat 5 mM 48 hrs, 4-day adult    3 Paraquat 10 mM 48 hrs, 4-day adult    3 Rotenone 2 μg 12 hrs, larvae L3    3 Rotenone 8 μg 12 hrs, larvae L3    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010, Graveley et al., 2011) mE2_34_mRNA_expression_cluster_31 mE1_20_mRNA_expression_cluster_04
External Data & Images
Linkouts	BDGP expression data • SD26148 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0003118 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG17077-RB;CG4412-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal, with Scer\GAL4pnr-MD237 pntGD1513 lethal | embryonic stage pntScer\UAS.P1.cZa lethal | embryonic stage, with Scer\GAL4nos.PG pntP1.Scer\UAS lethal | embryonic stage | recessive pnt1 pnt2 pntrM254 pntS118306 pntT5 pntunspecified pntΔ88 lethal | larval stage | recessive pnt1202 pnt1230 pntS060807a pntT9 lethal | pupal stage, with Scer\GAL4pnr-MD237 pntGD1513 lethal | pupal stage | recessive pnt1208 pntS099812 lethal | recessive pnt1216 pnt03520 pnt03680 pnt03805 pnt05484 pnt05484Δ33 pnt07825 pnt07825Δ78 pntAF397 pntAP553 pntj1B7 pntKG04968 pntrG324 pntrH719 pntrM254 pntrP229 pntrQ492 pntS012309 pntS060807a pntunspecified pntΔ18 pntΔ56 pntΔ81 pntΔ88 pntΔ114 viable pnt1277 pntEY03254 pntLA00739 viable, with Scer\GAL4nos.PG pntP2.Scer\UAS Sterility Allele female semi-sterile, with Scer\GAL455B pntP1.Scer\UAS female semi-sterile, with Scer\GAL4c324a pntP1.Scer\UAS female sterile, with Scer\GAL455B pntP1.Scer\UAS female sterile, with Scer\GAL4c324a pntP1.Scer\UAS fertile pntEY03254 pntLA00739 Other Phenotypes Allele cell polarity defective (with pnt1277) pntΔ88 cell polarity defective (with pntΔ88) pnt1277 mitotic cell cycle defective | somatic clone pntΔ88 neuroanatomy defective pntΔ88 neuroanatomy defective | larval stage, with Scer\GAL4elav-C155 pntScer\UAS.P1.cZa neuroanatomy defective | larval stage, with Scer\GAL80ts.αTub84B pntScer\UAS.P1.cZa neuroanatomy defective | larval stage | somatic clone pnt05484Δ33 planar polarity defective, with Scer\GAL4hs.2sev pntP2.Scer\UAS planar polarity defective (with pnt1230) pnt1277 pntΔ88 planar polarity defective (with pnt1277) pnt1230 pntΔ88 planar polarity defective (with pntKG04968) pntΔ88 planar polarity defective (with pntΔ88) pnt1230 pnt1277 pntKG04968 size defective, with Scer\GAL4ey.PU pntP1.Scer\UAS visible, with Scer\GAL471B pntP1.Scer\UAS visible, with Scer\GAL4dpp.blk1 pntP1.Scer\UAS visible, with Scer\GAL4ey.PU pntP1.Scer\UAS visible (with pnt1277) pntΔ88 visible (with pntΔ88) pnt1277 visible | dominant pntKG04968 visible | homeotic, with Scer\GAL4ey.PB pntP1.Scer\UAS Phenotype manifest in Allele A1-7 dorsal acute muscle 1 pntΔ88 A1-7 ventral acute muscle 2 | precursor pntΔ88 abdominal 1 anterior commissure pntΔ18 pntΔ56 abdominal 1 lateral pentascolopidial chordotonal organ lch5 pnt07825Δ78 abdominal 1 posterior commissure pntΔ18 pntΔ56 abdominal 1 ventral monoscolopidial chordotonal organ vch1 pnt07825Δ78 abdominal 2 anterior commissure pntΔ18 pntΔ56 abdominal 2 lateral pentascolopidial chordotonal organ lch5 pnt07825Δ78 abdominal 2 posterior commissure pntΔ18 pntΔ56 abdominal 2 ventral monoscolopidial chordotonal organ vch1 pnt07825Δ78 abdominal 3 anterior commissure pntΔ18 pntΔ56 abdominal 3 lateral pentascolopidial chordotonal organ lch5 pnt07825Δ78 abdominal 3 posterior commissure pntΔ18 pntΔ56 abdominal 3 ventral monoscolopidial chordotonal organ vch1 pnt07825Δ78 abdominal 4 anterior commissure pntΔ18 pntΔ56 abdominal 4 lateral pentascolopidial chordotonal organ lch5 pnt07825Δ78 abdominal 4 posterior commissure pntΔ18 pntΔ56 abdominal 4 ventral monoscolopidial chordotonal organ vch1 pnt07825Δ78 abdominal 5 anterior commissure pntΔ18 pntΔ56 abdominal 5 lateral pentascolopidial chordotonal organ lch5 pnt07825Δ78 abdominal 5 posterior commissure pntΔ18 pntΔ56 abdominal 5 ventral monoscolopidial chordotonal organ vch1 pnt07825Δ78 abdominal 6 anterior commissure pntΔ18 pntΔ56 abdominal 6 lateral pentascolopidial chordotonal organ lch5 pnt07825Δ78 abdominal 6 posterior commissure pntΔ18 pntΔ56 abdominal 6 ventral monoscolopidial chordotonal organ vch1 pnt07825Δ78 abdominal 7 anterior commissure pntΔ18 pntΔ56 abdominal 7 lateral pentascolopidial chordotonal organ lch5 pnt07825Δ78 abdominal 7 posterior commissure pntΔ18 pntΔ56 abdominal 7 ventral monoscolopidial chordotonal organ vch1 pnt07825Δ78 abdominal 8 anterior commissure pntΔ18 pntΔ56 abdominal 8 posterior commissure pntΔ18 pntΔ56 abdominal neuromere pnt3D2-026 adult salivary gland primordium pnt2 antenna | ectopic, with Scer\GAL4ey.PB pntP1.Scer\UAS anterior commissure pntunspecified anterior fascicle sensory neuron pntΔ88 Bolwig nerve pntΔ88 bract | somatic clone pntΔ88 cardioblast, with Scer\GAL4twi.PG pntP1.Scer\UAS cardioblast | ectopic pntΔ88 pntdsRNA.P2 pntRR112 pntS012309 cardioblast | ectopic | somatic clone pntunspecified central nervous system pntΔ81 central nervous system, with Scer\GAL4rho.PL pntP1.Scer\UAS central nervous system, with Scer\GAL4sca-537.4 pntP1.Scer\UAS cephalopharyngeal skeleton pntunspecified cephalopharyngeal skeleton, with Scer\GAL4nos.PG pntP1.Scer\UAS commissure pntΔ88 pntunspecified commissure, with Scer\GAL4rho.PL pntP1.Scer\UAS commissure, with Scer\GAL4sca-537.4 pntP1.Scer\UAS cone cell | ectopic, with Scer\GAL4GMR.PF pntP2.Scer\UAS.T:Zzzz\FLAG denticle belt pntΔ88 pntunspecified dorsal acute muscle | precursor, with Scer\GAL4twi.PB pntP2.Scer\UAS.T:Hsim\VP16 dorsal air sac primordium | somatic clone pntΔ88 pnt05484Δ33 pnt07825Δ78 dorsal appendage, with Scer\GAL455B pntP1.Scer\UAS dorsal appendage, with Scer\GAL4c324a pntP1.Scer\UAS dorsal appendage, with Scer\GAL4c532 pntP2.Scer\UAS dorsal appendage | maternal effect | somatic clone pntΔ88 pnt05484Δ33 pnt07825Δ78 dorsal branch primordium pntΔ88 pnt737 dorsal neurohemal organ pntΔ114 pntrM254 dorsal oblique muscle | ectopic | precursor, with Scer\GAL4twi.PB pntP2.Scer\UAS.T:Hsim\VP16 embryo pntdsRNA.P1 embryonic/first instar larval cuticle pntΔ88 embryonic/first instar larval cuticle | ventral pntΔ88 pnt2 embryonic/larval brain | larval stage | ventral, with Scer\GAL80ts.αTub84B pntScer\UAS.P1.cZa embryonic/larval dorsal branch & terminal tracheal cell | somatic clone pntΔ88 pntunspecified pnt198 pnt1318 embryonic/larval dorsal trunk pntΔ88 embryonic/larval glial cell pntΔ88 embryonic/larval pericardial cell pntΔ88 embryonic/larval trachea, with Scer\GAL4btl.PS pntP1.Scer\UAS embryonic/larval tracheal system pnt198 pnt1313 embryonic anterior Malpighian tubule pntΔ88 embryonic Malpighian tubule pnt1 embryonic pericardial cell pntS012309 embryonic pericardial cell, with Scer\GAL4twi.PG pntP1.Scer\UAS embryonic posterior Malpighian tubule pntΔ88 embryonic ventral epidermis pnt1 exit glial cell pntΔ88 eye pnt03520 pnt03680 pnt07825Δ78 eye, with Scer\GAL4ey.PB pntP1.Scer\UAS eye, with Scer\GAL4ey.PU pntP1.Scer\UAS eye, with Scer\GAL4hs.2sev pntP1.Scer\UAS eye (with pnt1277) pntΔ88 eye (with pntΔ88) pnt1277 eye | somatic clone pnt1230 eye disc | somatic clone pntΔ88 eye photoreceptor cell pntΔ88 pnt1277 eye photoreceptor cell, with Scer\GAL4sca-T3 pntP1.Scer\UAS eye photoreceptor cell (with pnt1277) pntΔ88 eye photoreceptor cell (with pntΔ88) pnt1277 ganglionic branch primordium pnt737 gastric caecum pntΔ88 pnt2 genital disc primordium pntΔ88 germarium, with Scer\GAL4unspecified pntVDRC.cUa glial cell pntΔ88 glial cell, with Scer\GAL4repo pntGD1513 hemocyte, with Scer\GAL4He.PZ pntP1.Scer\UAS hemocyte, with Scer\GAL4Hml.PG pntP1.Scer\UAS interface glial cell pntrM254 interface glial cell | ectopic, with Scer\GAL4sca-537.4 pntP1.Scer\UAS lateral trunk anterior branch pnt737 lch5 neuron | embryonic stage pntS012309 longitudinal connective pntunspecified macrochaeta pntL94F macrochaeta | ectopic, with Scer\GAL4dpp.blk1 pntP1.Scer\UAS Malpighian tubule pntΔ88 melanotic mass, with Scer\GAL4He.PZ pntP1.Scer\UAS melanotic mass, with Scer\GAL4Hml.PG pntP1.Scer\UAS mesoderm pntΔ88 mesoderm, with Scer\GAL4twi.PG pntP2.Scer\UAS.T:Hsim\VP16 midgut, with Scer\GAL4esg-NP5130, Scer\GAL80ts.αTub84B pntdsRNA.Scer\UAS.cUa midgut chamber 3 pntΔ88 pnt2 midgut constriction 1 pntΔ88 pnt2 midline glial cell pntΔ114 pntΔ88 pnt3D2-026 pntrM254 pntunspecified midline glial cell, with Scer\GAL4sim.PS pntP1.Scer\UAS mitotic cell cycle | somatic clone pntΔ88 morphogenetic furrow | ectopic, with Scer\GAL4dpp.blk1 pntP1.Scer\UAS motor neuron pntunspecified muscle founder cell | supernumerary, with Scer\GAL41151 pntP1.Scer\UAS ommatidial precursor cluster | somatic clone pntΔ88 ommatidium, with Scer\GAL4hs.2sev pntP1.Scer\UAS pntP2.Scer\UAS ommatidium, with Scer\GAL4sca-T3 pntP1.Scer\UAS ommatidium (with pnt1230) pntΔ88 pnt1277 ommatidium (with pnt1277) pntΔ88 pnt1230 ommatidium (with pntKG04968) pntΔ88 ommatidium (with pntT6) pntΔ88 ommatidium (with pntΔ88) pnt1230 pnt1277 pntKG04968 pntT6 ommatidium | somatic clone pnt1230 pericardial cell | ectopic | precursor, with Scer\GAL4twi.PB pntP2.Scer\UAS.T:Hsim\VP16 photoreceptor pnt03520 pnt03680 photoreceptor (with pnt1277) pntΔ88 photoreceptor (with pntΔ88) pnt1277 photoreceptor cell R1 | somatic clone pnt1230 photoreceptor cell R2 | somatic clone pntΔ88 photoreceptor cell R3 | somatic clone pntΔ88 photoreceptor cell R4 | somatic clone pntΔ88 photoreceptor cell R5 | somatic clone pntΔ88 photoreceptor cell R6 | somatic clone pnt1230 photoreceptor cell R7 pntΔ88 pnt1277 photoreceptor cell R7, with Scer\GAL4hs.2sev pntP2.Scer\UAS photoreceptor cell R7 (with pnt1277) pntΔ88 photoreceptor cell R7 (with pntT6) pntΔ88 photoreceptor cell R7 (with pntΔ88) pnt1277 pntT6 photoreceptor cell R7 | somatic clone pnt1230 photoreceptor cell R8, with Scer\GAL4sca-T3 pntP1.Scer\UAS pigment cell, with Scer\GAL4hs.2sev pntP1.Scer\UAS posterior fascicle sensory neuron pntΔ88 presumptive embryonic/larval central nervous system pntrM254 pntunspecified presumptive embryonic/larval peripheral nervous system pntunspecified presumptive embryonic/larval tracheal system pntΔ88 presumptive embryonic/larval tracheal system (with pnt737) pntΔ88 presumptive embryonic/larval tracheal system (with pntΔ88) pnt737 rhabdomere R8, with Scer\GAL4sca-T3 pntP1.Scer\UAS secondary neuroblast | ectopic | larval stage, with Scer\GAL80ts.αTub84B pntScer\UAS.P1.cZa secondary neuroblast | ectopic | larval stage | somatic clone, with Scer\GAL4elav-C155 pntScer\UAS.P1.cZa sensory neuron pntunspecified spectrosome | supernumerary, with Scer\GAL4unspecified pntVDRC.cUa stomatogastric nervous system pnt05484 pnt07825 submarginal cell, with Scer\GAL471B pntP1.Scer\UAS terminal tracheal cell pnt198 pnt1313 trachea pntΔ81 pntΔ88 type II neuroblast | larval stage | somatic clone pnt05484Δ33 ventral nerve cord pntΔ88 ventral nerve cord | larval stage, with Scer\GAL80ts.αTub84B pntScer\UAS.P1.cZa visceral mesoderm pntΔ88 pnt2 wing pntKG04968 wing, with Scer\GAL471B pntP1.Scer\UAS wing, with Scer\GAL4dpp.blk1 pntP1.Scer\UAS wing disc pnt1230 wing disc, with Scer\GAL4dpp.blk1 pntP1.Scer\UAS wing vein L4, with Scer\GAL471B pntP1.Scer\UAS
Classical Alleles ( 92 )
For All Classical Alleles Show
Allele of pnt Class Mutagen Stocks Known lesion pntΔ88 loss of function allele, amorphic allele - genetic evidence Delta2-3 2 Yes pnt2 loss of function allele ethyl methanesulfonate 2 Yes pntKG04968 P-element activity 2 -- pntLA00739 P-element activity 2 -- pntNP2185 2 -- pnt07825 P-element activity 1 Yes pnt1277 hypomorphic allele - genetic evidence Delta2-3 1 Yes pntc00584 piggyBac transposase 1 -- pntCB-6047-3 1 -- pntCB-6194-3 1 -- pntCB-6420-3 1 -- pntd00078 P-element activity 1 -- pntd01415 P-element activity 1 -- pntd02978 P-element activity 1 -- pntd07131 P-element activity 1 -- pntd07883 P-element activity 1 -- pntEY03254 P-element activity 1 -- pntf01588 piggyBac transposase 1 -- pntMB01157 1 -- pntMI02427 1 -- pntMI03880 1 -- pntMI07710 1 -- pntNP2172 1 -- pntNP3124 1 -- pntNP3368 1 -- pntNP5370 1 -- pntNP5402 1 -- pntNP6578 1 -- pntNP6678 1 -- pntUM-8016-3 1 -- pnt16.1 amorphic allele - genetic evidence ethyl methanesulfonate 0 -- pnt1 loss of function allele, amorphic allele - genetic evidence ethyl methanesulfonate 0 -- pntrM254 amorphic allele - genetic evidence Delta2-3 0 Yes pntΔ81 amorphic allele - genetic evidence Delta2-3 0 Yes pnt03520 P-element activity 0 Yes pnt03680 P-element activity 0 Yes pnt03805 P-element activity 0 -- pnt04263b P-element activity 0 -- pnt04877b P-element activity 0 -- pnt05484 P-element activity 0 Yes pnt05484Δ33 P-element activity 0 Yes pnt07825Δ78 loss of function allele P-element activity 0 Yes pnt115-1 Delta2-3 0 -- pnt1202 Delta2-3 0 Yes pnt1208 Delta2-3 0 Yes pnt1216 Delta2-3 0 -- pnt1230 hypomorphic allele - genetic evidence Delta2-3 0 Yes pnt1313 ethyl methanesulfonate 0 -- pnt1318 ethyl methanesulfonate 0 -- pnt15166 0 -- pnt19099 0 -- pnt198 ethyl methanesulfonate 0 -- pnt3680Δ21 0 -- pnt3D2-026 ethyl methanesulfonate 0 -- pnt737 hypomorphic allele - genetic evidence ethyl methanesulfonate 0 -- pnt7825Δ77 0 -- pntAF397 X ray ethyl methanesulfonate 0 -- pntAP553 X ray ethyl methanesulfonate 0 -- pntd00286 P-element activity 0 -- pntd07175 P-element activity 0 -- pntd07563 0 -- pntE88 0 -- pnteAL13 ethyl methanesulfonate 0 -- pnteAS7a ethyl methanesulfonate 0 -- pntEP3-1638 0 -- pntEP3-1859 0 -- pntEP3-637 0 -- pntEP3-853 0 -- pnteT13 ethyl methanesulfonate 0 -- pntj1B7 P-element activity 0 -- pntksh-14 ethyl methanesulfonate 0 -- pntL94F P-element activity 0 Yes pntpjc-5 ethyl methanesulfonate 0 -- pntpjc-6 ethyl methanesulfonate 0 -- pntrG324 P-element activity 0 -- pntrH719 P-element activity 0 -- pntrP229 P-element activity 0 -- pntrQ492 P-element activity 0 -- pntRR112 0 Yes pntS012309 Delta2-3 P-element activity 0 -- pntS060807a Delta2-3 P-element activity 0 -- pntS099812 Delta2-3 P-element activity 0 -- pntS118306 P-element activity 0 -- pntT5 X ray 0 Yes pntT6 0 -- pntT9 X ray 0 Yes pntunspecified 0 -- pntXI-E2 ethyl methanesulfonate 0 -- pntΔ114 Delta2-3 0 Yes pntΔ18 Delta2-3 0 Yes pntΔ56 Delta2-3 0 Yes pntΔ86 0 --
Alleles Carried on Transgenic Constructs ( 28 )
For All Alleles Carried on Transgenic Constructs Show
Allele of pnt Class Mutagen Stocks Known lesion pntGD1513 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes pntP1.Scer\UAS in vitro construct - regulatory fusion 2 Yes pntP2.Scer\UAS in vitro construct - regulatory fusion 2 Yes pntHMS01452 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes pntJF02227 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes pntKK100473 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes pntP2.Scer\UAS.T:Hsim\VP16 in vitro construct - regulatory fusion in vitro construct - coding region fusion 1 Yes pntT:Avic\GFP-SF,T:Zzzz\FLAG,T:Zzzz\PSP.CS,T:Zzzz\TEV.CS,T:Zzzz\BLRP in vitro construct - coding region fusion 1 Yes pntD237R.MtnA in vitro construct - amino acid replacement 0 Yes pntdsRNA.P1 in vitro construct - RNAi 0 Yes pntdsRNA.P2 in vitro construct - RNAi 0 Yes pntdsRNA.Scer\UAS.cUa in vitro construct - regulatory fusion in vitro construct - RNAi 0 Yes pntE241R.MtnA in vitro construct - amino acid replacement 0 Yes pntF201A.MtnA in vitro construct - amino acid replacement 0 Yes pntF234A.MtnA in vitro construct - amino acid replacement 0 Yes pntI238R.MtnA in vitro construct - amino acid replacement 0 Yes pntL203E.MtnA in vitro construct - amino acid replacement 0 Yes pntL228R.MtnA in vitro construct - amino acid replacement 0 Yes pntMtnA.PQ in vitro construct - regulatory fusion 0 Yes pntP1.Act5C in vitro construct - regulatory fusion 0 Yes pntP1.MtnA in vitro construct - regulatory fusion 0 Yes pntP1.Y.Act5C in vitro construct - regulatory fusion 0 Yes pntP2.Act5C in vitro construct - regulatory fusion 0 Yes pntP2.Scer\UAS.T:Zzzz\FLAG in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes pntP2T151A.Act5C.P in vitro construct - amino acid replacement in vitro construct - regulatory fusion 0 Yes pntScer\UAS.P1.cZa in vitro construct - regulatory fusion 0 Yes pntT151A.Scer\UAS in vitro construct - regulatory fusion in vitro construct - site directed mutagenesis in vitro construct - amino acid replacement 0 Yes pntVDRC.cUa in vitro construct - regulatory fusion in vitro construct - RNAi 0 Yes
Aneuploid Aberrations
Not disrupted in	Df(3L)st-j7 (BDGP Project Members, 1994-1999) Df(3R)5C1 (Klaembt, 1996.12.4) Df(3R)23D1 (Szeged Stock Center, 1998-) Df(3R)e-N19 (BDGP Project Members, 1994-1999) Df(3R)hhE23 (Spradling et al., 1999, BDGP Project Members, 1994-1999) Ts(YSt;3Lt)R13 (Tearle and Nusslein-Volhard, 1987)
Disrupted in	Df(3R)23D1 (Klaembt, 1996.12.4) Df(3R)B204 (Jurgens et al., 1984) Df(3R)BSC56 (Andrade et al., 2004.9.20) Df(3R)Exel9012 (Ryder, 2004.4.26) Df(3R)M95A (Ghabrial et al., 2011) Ts(YLt;3Lt)B27 (Jurgens et al., 1984, Tearle and Nusslein-Volhard, 1987) Ts(YLt;3Lt)B172 (Jurgens et al., 1984)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD1513} NA P{KK100473} NA P{TRiP.HMS01452} NA P{TRiP.JF02227} NA P{UAS-pnt.P1.Z} NA P{UAS-pnt.P1} NA P{UAS-pnt.P2.FLAG} NA P{UAS-pnt.P2.T151A} NA P{UAS-pnt.P2} NA P{UAS-pnt.RNAi.U} NA P{UAS-pntP2VP16} NA characterization construct P{VDRC.pnt.U} NA PBac{pnt-GFP.FPTB} NA
Insertions
	Type of insertions Name Expression data insertion of enhancer trap P{A92}pntrM254 No P{lacW}l(3)SH070SH070 No P{lacW}pnt115-1 No P{lacW}pnt1277 No P{lacW}pntj1B7 No P{lacW}pntS012309 No P{lacW}pntS060807a No P{lacW}pntS099812 No P{lArB}pntL94F No P{PZ}pnt03520 No P{PZ}pnt03680 No P{PZ}pnt03805 No P{PZ}pnt04263b No P{PZ}pnt04877b No P{PZ}pnt05484 No P{PZ}pnt07825 No P{PZ}pntrG324 No P{PZ}pntrH719 No P{PZ}pntrP229 No P{PZ}pntrQ492 No insertion of mobile activating element P{EP}pntEP3-637 NA P{EP}pntEP3-853 NA P{EP}pntEP3-1638 NA P{EP}pntEP3-1859 NA P{EPgy2}pntEY03254 NA P{GSV1}EP-111EP-111 NA P{GSV1}GSd201GSd201 NA P{GSV1}GSd229GSd229 NA P{GSV1}GSd236GSd236 NA P{GSV1}GSd420GSd420 NA P{Mae-UAS.6.11}B2038B2038 NA P{Mae-UAS.6.11}pntLA00739 NA P{XP}pntd00078 NA P{XP}pntd00286 NA P{XP}pntd01415 NA P{XP}pntd02978 NA P{XP}pntd07131 NA P{XP}pntd07175 NA P{XP}pntd07563 NA P{XP}pntd07883 NA miscellaneous insertions Mi{MIC}pntMI02427 NA Mi{MIC}pntMI03880 NA Mi{MIC}pntMI07710 NA P{?A92}pntΔ18 NA P{?A92}pntΔ56 NA P{RS3}pntCB-6047-3 NA P{RS3}pntCB-6194-3 NA P{RS3}pntCB-6420-3 NA P{RS3}pntUM-8016-3 NA P{SUPor-P}pntKG04968 NA PBac{PB}pntc00584 NA PBac{WH}pntf01588 NA insertion of enhancer trap binary system Mi{ET1}pntMB01157 No P{GawB}DJ626 No P{GawB}pntNP2172 No P{GawB}pntNP2185 No P{GawB}pntNP3124 No P{GawB}pntNP3368 No P{GawB}pntNP5370 No P{GawB}pntNP5402 No P{GawB}pntNP6578 No P{GawB}pntNP6678 No
Gene Ontology: Function, Process & Cellular Component ( 39 unique terms )
Terms Based on Experimental Evidence ( 28 terms )
Molecular Function
CV term Evidence References
protein binding inferred from physical interaction with edl (Baker et al., 2001) repressing transcription factor binding inferred from physical interaction with edl (Yamada et al., 2003) contributes_to RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription inferred from direct assay (Yuasa et al., 2003) sequence-specific DNA binding RNA polymerase II transcription factor activity inferred from direct assay (Yamada et al., 2003)
Biological Process
CV term Evidence References
determination of genital disc primordium inferred from mutant phenotype (Chen et al., 2005) epithelial cell migration, open tracheal system inferred from mutant phenotype (Hsouna et al., 2010) epithelial cell proliferation involved in Malpighian tubule morphogenesis inferred from mutant phenotype (Kerber et al., 1998) eye-antennal disc morphogenesis inferred from mutant phenotype (Brown et al., 2006) imaginal disc-derived wing morphogenesis inferred from mutant phenotype (Dworkin and Gibson, 2006) muscle fiber development inferred from mutant phenotype (Dutta et al., 2005) negative regulation of apoptotic process inferred from genetic interaction with W (Kurada and White, 1998) negative regulation of cardioblast cell fate specification inferred from mutant phenotype (Alvarez et al., 2003) pericardial nephrocyte differentiation inferred from mutant phenotype (Alvarez et al., 2003) phagocytosis, engulfment inferred from mutant phenotype (Stroschein-Stevenson et al., 2006) positive regulation of cell proliferation inferred from mutant phenotype (Buchon et al., 2010) positive regulation of transcription from RNA polymerase II promoter inferred from direct assay (Yamada et al., 2003) inferred from mutant phenotype (Ohshiro et al., 2002) primary branching, open tracheal system inferred from mutant phenotype (Myat et al., 2005) R3/R4 cell fate commitment inferred from mutant phenotype (Weber et al., 2008) regulation of hemocyte differentiation inferred from mutant phenotype (Zettervall et al., 2004) regulation of neurogenesis inferred from mutant phenotype (Zhu et al., 2011) secondary branching, open tracheal system inferred from mutant phenotype (Ribeiro et al., 2002) terminal region determination inferred from genetic interaction with tor (Strecker et al., 1991) torso signaling pathway inferred from genetic interaction with tor (Strecker et al., 1991) trachea development inferred from mutant phenotype (Mortimer and Moberg, 2009) tracheal outgrowth, open tracheal system inferred from mutant phenotype (Cabernard and Affolter, 2005) trachea morphogenesis inferred from mutant phenotype (Ghabrial et al., 2011) wing disc dorsal/ventral pattern formation inferred from genetic interaction with Bx, ap (Bejarano et al., 2008)
Cellular Component
CV term Evidence References
nucleus inferred from direct assay (Brunner et al., 1994)
Terms Based on Predictions or Assertions ( 13 terms )
Molecular Function
CV term Evidence References
sequence-specific DNA binding inferred from electronic annotation with InterPro:IPR000418, InterPro:IPR003118 (FlyBase Curators et al., 2004-) sequence-specific DNA binding transcription factor activity inferred from sequence or structural similarity with mouse Ets1 (FlyBase, 1992-)
Biological Process
CV term Evidence References
epidermal growth factor receptor signaling pathway non-traceable author statement (Canon and Banerjee, 2000) heart development non-traceable author statement (Cripps and Olson, 2002) traceable author statement (Lo and Frasch, 2003) heterophilic cell-cell adhesion non-traceable author statement (Swiss-Prot Project Members, 1990.11.1) open tracheal system development non-traceable author statement (Zelzer and Shilo, 2000) ovarian follicle cell development traceable author statement (Dobens and Raftery, 2000) peripheral nervous system development traceable author statement (Salzberg et al., 1994) R7 cell development traceable author statement (Kumar and Moses, 2000) Ras protein signal transduction traceable author statement (Kumar and Moses, 2000) regulation of transcription, DNA-dependent inferred from sequence or structural similarity with mouse Ets1 (FlyBase, 1992-) secondary branching, open tracheal system traceable author statement (Ghabrial et al., 2003)
Cellular Component
CV term Evidence References
nucleus inferred from sequence or structural similarity with mouse Ets1 (FlyBase, 1992-) non-traceable author statement (Swiss-Prot Project Members, 1990.11.1)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
protein-protein
Interacting group Assay References
pnt - Atx2 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23)
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions pnt allele Gene References pnt115-1 l(2)gl (Woodhouse et al., 2003) pnt1230 Jra (Treier et al., 1995) pnt1277 ALV\v-ets (Albagli et al., 1996) ed (Bai et al., 2001) faf (Isaksson et al., 1997) Jra (Treier et al., 1995) pnt07825 csw (Firth et al., 2000) CycE (Brumby et al., 2004) pnt07825Δ78 B-H1 (Hayashi et al., 1998) Dp (Staehling-Hampton et al., 1999) Dsor1 (O'Neill et al., 1994) phl (O'Neill et al., 1994) Ras85D (O'Neill et al., 1994) W (Kurada and White, 1998) pnt15166 Jra (Weber et al., 2000) pnt19099 Jra (Weber et al., 2000) pntAF397 aop (Rebay et al., 2000) phl (Rebay et al., 2000) Ras85D (Rebay et al., 2000) pntAP553 aop (Rebay et al., 2000) phl (Rebay et al., 2000) Ras85D (Rebay et al., 2000) pnteAL13 N (Verheyen et al., 1996) pnteAS7a N (Verheyen et al., 1996) pnteT13 N (Verheyen et al., 1996) pntksh-14 Dp (Staehling-Hampton et al., 1999) pntP2.Scer\UAS.T:Zzzz\FLAG edl (Vivekanand et al., 2004) pntP2.Scer\UAS phl (Yamada et al., 2003) pntpjc-5 Dp (Staehling-Hampton et al., 1999) pntpjc-6 Dp (Staehling-Hampton et al., 1999) pntT6 pros (Kauffmann et al., 1996) pntunspecified foi (Hummel et al., 1999) phl (Therrien et al., 2000) Ras85D (Therrien et al., 2000) spen (Chen and Rebay, 2000) sur (Hummel et al., 1999) pntΔ88 ALV\v-ets (Albagli et al., 1996) aos (Gaengel and Mlodzik, 2003) csw (Firth et al., 2000) ed (Bai et al., 2001) edl (Yamada et al., 2003) faf (Isaksson et al., 1997) fred (Chandra et al., 2003) h (Bianchi-Frias et al., 2004) Jra (Treier et al., 1995) pros (Kauffmann et al., 1996) Ras85D (Yang and Baker, 2003) stg (Baonza et al., 2002) unspecified E2f (Staehling-Hampton et al., 1999) grim (Mueller et al., 2005) Gug (Charroux et al., 2006) H (Mueller et al., 2005) kni (Myat et al., 2005) ksr (Therrien et al., 2000) p53 (Mueller et al., 2005) rpr (Mueller et al., 2005) W (Mueller et al., 2005)
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 67700 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0003118 DroID - A comprehensive database of gene and protein interactions. • FBgn0003118 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 42757 SignaLink - A protein-protein and protein-miRNA interaction database with multi-layered structure and multiple confidence scores. • P51023
Orthologs
OrthoDB Orthologs (46) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG61NV60 Dipteran inclusive ortholog search EOG6G4H02 Insect inclusive ortholog search EOG63JB1T Arthropod inclusive ortholog search EOG6DNCMF Metazoa inclusive ortholog search EOG68DCPQ
Orthologs in Drosophila Species (EOG61NV60)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\pnt     Drosophila simulans   Dsim\GD18390     Drosophila sechellia   Dsec\pnt Y   Drosophila erecta   Dere\GG12443 Y   Drosophila yakuba   Dyak\GE23966 Y   Drosophila ananassae   Dana\GF18013 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA30133 Y   Drosophila persimilis   Dper\GL23032 Y   Drosophila virilis   Dvir\GJ22870 Y   Drosophila mojavensis   Dmoj\GI23211 Y   Drosophila grimshawi   Dgri\GH20735 Y
Orthologs in non-Drosophila Dipterans (EOG6G4H02)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL003845   Anopheles gambiae Malaria mosquito  Agam\AGAP004619   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ008660
Orthologs in non-Dipteran Insects (EOG63JB1T)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\GB52625   Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG013047   Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH18477   Atta cephalotes Leafcutter ant  Acep\ACEP10364   Camponotus floridanus Florida carpenter ant  Cflo\CFLO20309   Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL22320   Linepithema humile Argentine ant  Lhum\LH14880   Linepithema humile Argentine ant  Lhum\LH14881   Pogonomyrmex barbatus Red harvester ant  Pbar\PB14921   Solenopsis invicta Red fire ant  Sinv\SINV23309   Solenopsis invicta Red fire ant  Sinv\SINV23310   Acyrthosiphon pisum Pea aphid  Apim\ACYPI24155   Bombyx mori Silkmoth  Bmor\BGIBMGA004974   Pediculus humanus Human body louse  Phum\PHUM420060   Tribolium castaneum Red flour beetle  Tcas\TC014512
Orthologs in non-Insect Arthropods (EOG6DNCMF)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\SGK3   Daphnia pulex Water flea  Dpux\ELO   Ixodes scapularis Deer tick  Isca\ISCW015690
Orthologs in non-Arthropod Metazoa (EOG68DCPQ)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_027053gn   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_002874gn   Danio rerio Zebrafish  Drer\ets2   Danio rerio Zebrafish  Drer\ENSDARG00000024431   Xenopus tropicalis Western clawed frog  Xtro\ets2   Xenopus tropicalis Western clawed frog  Xtro\ets1   Gallus gallus Domestic chicken  Ggal\ENSGALG00000001143   Gallus gallus Domestic chicken  Ggal\ETS2   Mus musculus House mouse  Mmus\Ets1   Mus musculus House mouse  Mmus\Ets2   Rattus norvegicus Norway rat  Rnor\Ets1   Rattus norvegicus Norway rat  Rnor\Ets2   Homo sapiens Human  Hsap\ETS2   Homo sapiens Human  Hsap\DKFZp686D0662
Human Orthologs (2)
Gene OMIM HGNC Hsap\ETS2     Hsap\DKFZp686D0662
AAA Orthologs (10) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila sechellia Dsec\pnt Drosophila erecta Dere\GG12443 Drosophila yakuba Dyak\GE23966 Drosophila ananassae Dana\GF18013 Drosophila pseudoobscura pseudoobscura Dpse\GA30133 Drosophila persimilis Dper\GL23032 Drosophila willistoni Dwil\GK12243 Drosophila virilis Dvir\GJ22870 Drosophila mojavensis Dmoj\GI23211 Drosophila grimshawi Dgri\GH20735
Stocks & Reagents
Stocks Listed in FlyBase ( 46 )
Bloomington	869 w1118; P{UAS-pnt.P1}3
Harvard	- P{XP}pntd00078 - P{XP}pntd01415 - P{XP}pntd02978 - P{XP}pntd07131 - P{XP}pntd07883 - PBac{PB}pntc00584 - PBac{WH}pntf01588
Kyoto	106101 w1118; P{UAS-pnt.P1}3 106100 pntΔ88/TM3, Sb1
VDRC	v105390 P{KK100473}VIE-260B v7171 w1118; P{GD1513}v7171
	More stocks available...
Genomic Clones ( 2 )
	BACR01E13 BACR03N12 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 90 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	GH05922 RE52147 SD17072 SD26148
Other clones	DPiM_RE52147 FI19015
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	GH06240 LD08639 RE14061 RE18543 RE64372 RE74191 RH13217 RH14307 RH32337 RH53220 RH61117 SD02588 SD03096 SD03128 SD03369 SD03752 SD04302 SD05848 SD06825 SD07058 SD09423 SD09435 SD10380 SD11389 SD15485 SD16773 SD18310 SD18707 SD20173 SD22353 SD23941 SD26250 SD26775
Other clones	16490 17982 62945 77410 102742 108821 145377 159901 166795 167269 193181 282123 475372 528332 557975 561886 569018 572752 CK01.8C.A8 CK01.61C.H12 CK01.142C.E3 EC051128 EC051207 EC051722 EC052670 EC053162 EC054645 EC055394 EC056635 EK048464 EK115818 EK170318 EK190150 EK200709 EK210761 EK235525 EK252250 EK271863 EK272321 EK307555 EN00761 EN09459 EN12741 EN13323 EN14353 EN17013 IP11343 RP004215720 RP004227123 SD15693 SD26445
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0003118 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 42757
Antibody Information
	polyclonal (Brunner et al., 1994, Avet-Rochex et al., 2012, Hsouna et al., 2010, Brunner et al., 1994)
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of
Additional comments
Other Comments
	pnt is required cell-autonomously along the dorsal midline to repress dorsal appendage fate. (Lachance et al., 2009) The pnt SAM domain is the docking surface for rl and this docking surface is essential for pnt-mediated enhancement of transactivation in response to Ras85D signaling. (Qiao et al., 2006) S2 cells treated with dsRNA generated against this gene show reduced phagocytosis of Candida albicans compared to untreated cells. (Stroschein-Stevenson et al., 2006) pnt activates ZAM expression in follicle cells. (Meignin et al., 2004) pnr and pntP2 act sequentially to regulate heart development. (Alvarez et al., 2003) The pnt protein isoform is an activator of stg mRNA transcription in the eye disc. (Baonza et al., 2002) Seven EMS induced alleles were identified in a screen for mutations affecting commissure formation in the CNS of the embryo. (Hummel et al., 1999) Candidate gene for quantitative trait (QTL) locus determining bristle number. (Nuzhdin et al., 1999) pnt is required for morphogenesis of the posterior midgut and is a target of abd-A. (Bilder et al., 1998) Identification: Enhancer trap expression pattern survey for loci expressed in the ring gland. (Harvie et al., 1998) ttk is required for proper glial cell development in the CNS. Phenotypes of doubly mutant ttk and pnt embryos and ectopic expression of ttk and pnt indicates the existance of two independent genetic pathways regulating glial cell development, which in the lateral glia are both downstream of gcm. One, mediated via pnt, results in the activation of glia cell differentiation, whereas the other, mediated by ttk, results in the suppression of neuronal differentiation in these cells. (Giesen et al., 1997) In the midline glial cells pntP2 has to be activated by phosphorylation, possibly through rl, to induce transcription of its target genes. aop antagonises pntP2 function in the midline glial cells. Jra and pntP2 do not cooperate during midline glia development. (Scholz et al., 1997, Scholz et al., 1997) In vivo culture of mutant discs from genotypes that are normally embryonic lethal demonstrates pnt is required for wing disc growth. (Simcox, 1997) The primary target genes of Egfr are pnt, vnd and Fas3, these are induced in different ectodermal domains. Secondary target genes oc, argos and trn are activated by pnt in response to Egfr signalling. The proper induction of these genes requires the concomitant inactivation of aop, mediated by Egfr signalling. (Gabay et al., 1996) Inactivated mutations of Ras85D enhance the P{sevhs-cswCS} phenotype. (Herbst et al., 1996) pros gene becomes transcriptionally activated at a low level in all sev-competent cells prior to sev signaling and this requires the activities of Ras85D and two ETS transcription factors, aop and pnt. (Kauffmann et al., 1996) pnt is required in dorsal follicle cells for patterning of the cell layer into either appendage-producing or midline cells. Loss of pnt results in the loss of midline cells and an excess of appendage-forming cells, a phenotype associated with overactivation of the EGF receptor pathway in the dorsal region. Overexpression of pnt leads to a phenotype similar to that generated by loss of the EGF receptor pathway. Data indicates a novel antagonistic function for pnt in oogenesis: in response to activation of the EGF receptor pnt is expressed and negatively regulates the EGF receptor pathway, possibly by integrating information from a second pathway. (Morimoto et al., 1996) The pnt transcription factor is required for secondary branching and also to activate expression of terminal branch markers. (Samakovlis et al., 1996) Jra cooperates with the ETS domain pnt gene product to act on common target genes which induce photoreceptor R7 fate in the developing eye. phyl might be one of the target genes. (Treier et al., 1995) MAP kinase activity, encoded by the rl locus, induces neuronal differentiation by simultaneously inhibiting the aop repressor and stimulating the pnt activator. (Brunner et al., 1994) pnt is required for neuronal glial cell interactions: loss of function mutations lead to a change in the migration behavior of the midline glial cells. (Klambt, 1993) The pnt gene product is involved in the specification of the glial-neuronal interactions. The pnt locus has a complex organisation, it encodes two putative ETS-like transcription factors that are expressed in different non-overlapping sets of glial cells in the CNS. (Scholz et al., 1993) Two different and distinct trans-acting DNA domains control the pnt P2 promoter activity, one is an activator, the other a repressor. Enhancers directing tissue specific pnt P2 expression are located 3' to the first P2 exon within intronic sequences. Heteroallelic complementation reveals that the pnt gene product is required during eye, wing and haltere development. (Scholz et al., 1993) pnt has been cloned, sequenced and its RNA expression pattern characterised. (Chen et al., 1992) pnt gene product is required for the proper development of the ventralmost cuticle and the CNS midline. (Panzer et al., 1992) Zygotically active locus involved in the terminal developmental program in the embryo. (Strecker et al., 1991) rho, pnt, S and spi all function in the formation of the same chordotonal organs. (Bier et al., 1990) pnt mutants display a pointed head skeleton and deletion of the medial portion in all denticle belts. (Jurgens et al., 1984)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_079737 NM_170070 NM_170651 NM_001275943 RefSeq (Proteins) • NP_524461 NP_732857 NP_732858 NP_001262872 DDBJ / EMBL / GenBank • AAA28521 AAC34200 AAF56125 AAN13942 AAN13943 AAN71682 AF067896 AGB96252 AY863885 AY863886 AY863887 AY863888 AY863889 AY863890 AY863891 AY863892 AY863893 AY863894 AY863895 AY863896 AY863897 AY863898 AY863899 AY863900 AY863901 AY863902 AY863903 AY863904 AY863905 AY863906 BH740840 BI635658 BT001893 CAA48916 CAA48917 CL610132 CZ466575 CZ471367 CZ471505 CZ471506 CZ472220 CZ473108 CZ475553 CZ475577 CZ475979 CZ484052 CZ484053 DU708663 G00471 M20408 M88472 X69166 X69167 Entrez Gene - A searchable database of RefSeq genes. • 42757 UniProtKB/Swiss-Prot • P51022 P51023
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Ets domain (IPR000418) Pointed domain (IPR003118) Winged helix-turn-helix DNA-binding domain (IPR011991) Sterile alpha motif/pointed domain (IPR013761) BDGP expression data - Patterns of gene expression in Drosophila embryogenesis • SD26148
Linkouts
	BioGRID - A database of protein and genetic interactions • 67700 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0003118 DroID - A comprehensive database of gene and protein interactions. • FBgn0003118 DRSC - Results from RNAi screens. • FBgn0003118 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0003118 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG17077-RB;CG4412-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0003118 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 42757 Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution • /neural/pointed.htm InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 42757 modMine - Data generated by the modENCODE project. • FBgn0003118 REDfly - A database of transcriptional regulatory elements. • FBgn0003118 SignaLink - A protein-protein and protein-miRNA interaction database with multi-layered structure and multiple confidence scores. • P51023
Synonyms & Secondary IDs ( 49 )
Reported As
Symbol Synonym	0123/09 (Deak et al., 1997) 0608/07 (Deak et al., 1997) 0998/12 (Deak et al., 1997) 3520 (Harvie et al., 1998) CG17077 (Norga et al., 2003, Whitfield, 2000.11.3, Molnar et al., 2006, Grieder et al., 2007, Keleman et al., 2009.8.5, Baltzer et al., 2009, Perkins et al., 2009, Ni et al., 2011.7.19) D-ets-2 (Kumar and Moses, 2000, Chen, 1993.1.9, Pribyl et al., 1991, Pribyl et al., 1988) D-Ets-2 (Chen et al., 1992) DMPOINT1A (Colson and Goldstein, 1999, Kennington et al., 2006) E(E2F)3D (Staehling-Hampton et al., 1999) EK3-2 (Therrien et al., 2000) Ets (Aboukhalil and Bulyk, 2012) ETS2 (Wasylyk et al., 1993) Ets2   Ets58AB   ets94F   Ets94F   EY3-1 (Rebay et al., 2000) l(3)07825   l(3)j1B7   l(3)s118306 (Provost et al., 2006) png (Lee et al., 1999) pnt (Turner et al., 2008, McNeill et al., 2008, Dworkin and Gibson., 2006, Kim et al., 2007, Ghabrial and Krasnow, 2006, Dutta et al., 2005, Sellin et al., 2006, Liu et al., 2006, Estrada et al., 2006, Dworkin and Gibson, 2006, Mirkovic and Mlodzik, 2006, Charroux et al., 2006, Weng et al., 2012, Apitz et al., 2005, Zeitlinger et al., 2007, Sandmann et al., 2007, Stroschein-Stevenson et al., 2006, Stathopoulos and Levine, 2005, Mackay et al., 2012, Aerts et al., 2007, Tie et al., 2012, Butchar et al., 2012, Zhao et al., 2008, Yu et al., 2008, Galindo et al., 2005, Spokony, 2012.12.12, Jakobsen et al., 2007, Brown et al., 2006, Meignin et al., 2004, de Navascués and Modolell, 2007, Mirkovic et al., 2011, Maeda et al., 2007, Molnar et al., 2006, Grieder et al., 2007, Geng and MacDonald, 2007, Macdonald and Long, 2005, Melen et al., 2005, Minidorff et al., 2007, Sukhanova et al., 2007, Firth and Baker, 2005, Kankel et al., 2007, Mortimer and Moberg, 2009, Minidorff et al., 2007, Moses et al., 2011, Southall and Brand, 2009, Debat et al., 2009, Hwang and Rulifson, 2011, Sun et al., 2011, Sandmann et al., 2006, Nishimura et al., 2007, Firth and Baker, 2007, Tseng et al., 2007, Paul et al., 2006, Polesello and Tapon, 2007, Meignin et al., 2007, Kwon et al., 2008, Devergne et al., 2007, Rawlings et al., 2004, Berger et al., 2008, Liu et al., 2009, Junion et al., 2007, Zartman et al., 2008, Cabernard and Affolter, 2005, Huh et al., 2009, Lembong et al., 2009, Krejcí et al., 2009, Wertheim et al., 2011, Lindner et al., 2007, Read et al., 2009, Mou et al., 2012, zur Lage et al., 2004, Tsubouchi et al., 2009, Franzdóttir et al., 2009, Zartman et al., 2009, Flaherty et al., 2009, Lachance et al., 2009, Baker et al., 2009, Zeitlinger et al., 2007, Brodu et al., 2004, Bantignies et al., 2011, Wang et al., 2004, Weber et al., 2008, Fetting et al., 2009, Oishi et al., 2006, Liebl and Featherstone, 2005, Becalska and Gavis, 2010, Chanut-Delalande et al., 2010, Salzer et al., 2010, Song et al., 2009, Hsouna et al., 2010, Rendina et al., 2010, Chang et al., 2001, Liu et al., 2010, Shen et al., 2009, Aerts et al., 2010, Cherbas et al., 2011, Fulkerson and Estes, 2011, Araújo and Casanova, 2011, Morozova et al., 2010, Dworkin et al., 2011, Lavenburg et al., 2003, Zhan et al., 2010, Verma et al., 2012, Jiang et al., 2010, Jones et al., 2012, Zhu et al., 2011, Ghabrial et al., 2011, Chang et al., 2003, Technau et al., 2012, Nawaz et al., 2012, Herz et al., 2012, Simakov et al., 2012, Manning et al., 2012, Weber et al., 2012) Pnt (Mason et al., 2006, Graham et al., 2008, Hsouna and Hsu, 2008, Philippakis et al., 2006, Kawamori et al., 2011, Bernardi et al., 2007, Papatsenko et al., 2009, Ragab et al., 2011, Peng et al., 2012, Tian and Deng, 2008, Leatherbarrow and Halfon, 2009, Graham et al., 2010, Roignant and Treisman, 2010, Xiao et al., 2012) pntegfr (Fuchs et al., 2012) PNT-P1 (Carthew, 2006) PNTP1 (Yamada et al., 2003) PntP1 (Roignant et al., 2006, Graham et al., 2010, Yasugi et al., 2010) pnt-P1 (Kim et al., 2006) Pnt-P1 (Li et al., 2009) pnt-P2 (Qiao et al., 2006) PNTP2 (Tootle and Rebay, 2005, Yamada et al., 2003) PntP2 (Rogers and Barolo, 2006, Voas and Rebay, 2004, Graham et al., 2010, Vivekanand and Rebay, 2012) pntP2 (Kaul and Bateman, 2007, Galindo et al., 2005) POINT (Colson and Goldstein, 1999) pointed (Halfon and Leatherbarrow, 2007) Pointed-P1 (Li and Carthew, 2005) pointed-RC (Bianchi-Frias et al., 2004) ptd (Dobens and Raftery, 2000) unnamed (Treisman and Rubin, 1996)
Name Synonym	Ets at 58AB   Ets protein Pointed P2 (Kockel et al., 2001) no terminal cell clones-R (Ghabrial et al., 2011) pnt (Yu et al., 2008) pointed (Turner et al., 2008, Jafar-Nejad and Bellen, 2004, Baker, 2004, Roignant et al., 2007, Sambandan et al., 2006, Dworkin and Gibson, 2006, Urban, 2006, Zhao et al., 2008, Maeda et al., 2007, Bejarano et al., 2008, Firth and Baker, 2005, Kankel et al., 2007, Singer and Gall, 2011, Moses et al., 2011, Firth and Baker, 2007, Polesello and Tapon, 2007, Meignin et al., 2007, Devergne et al., 2007, Rawlings et al., 2004, Hurlbut et al., 2009, Mok et al., 2005, Krejcí et al., 2009, Wertheim et al., 2011, Lindner et al., 2007, Read et al., 2009, Brodu et al., 2004, Oishi et al., 2006, Franzdóttir et al., 2009, Becalska and Gavis, 2010, Salzer et al., 2010, Hsouna et al., 2010, Lee et al., 1999, Chang et al., 2001, Liu et al., 2010, Shen et al., 2009, Sonnenfeld et al., 2010, Kaplow et al., 2007, Ghabrial et al., 2011, Jones et al., 2012, Aboukhalil and Bulyk, 2012) Pointed (Yuasa and Hiromi, 2007, Jemc and Rebay, 2007, Rogers et al., 2005, Cela and Llimargas, 2006, Yoneda et al., 2007, Brown et al., 2006, Letizia et al., 2007, Graham et al., 2008, Hsouna and Hsu, 2008, Philippakis et al., 2006, Sukhanova et al., 2007, Bernardi et al., 2007, Figeac et al., 2010, Weber et al., 2008, Buchon et al., 2009, Baltzer et al., 2009, Jiang et al., 2010, Graham et al., 2010, Aerts et al., 2010, Buchon et al., 2010, Fulkerson and Estes, 2011, Fuchs et al., 2012, Technau et al., 2012) Pointed2 (Meignin et al., 2004) pointed-P1 (Klaembt, 1992.11.2, Colson, 1998.5.26, Kim et al., 2006) pointedP2 (Skeath et al., 2003, Kaul and Bateman, 2007, Galindo et al., 2005) pointed-P2 (Klaembt, 1992.11.2) PointedP2 (Bernardi et al., 2007) pointed P2 (Paul et al., 2006)
Secondary FlyBase IDs
	FBgn0004060 FBgn0005657 FBgn0010925 FBgn0011309
References ( 526 )
Generate a list of	All references relating to this gene ( 526 )
List References by type	Research paper  ( 319 ) Supplementary material  ( 11 ) Review  ( 88 ) Erratum  ( 1 ) Personal communication to FlyBase  ( 27 ) Abstract  ( 63 ) FlyBase analysis  ( 2 ) DNA/RNA sequence record  ( 4 ) Stock list  ( 2 ) Protein sequence record  ( 1 ) Website  ( 1 ) Teaching note  ( 1 ) Curated genome annotation  ( 2 ) Letter  ( 1 ) Book  ( 1 ) Conference report  ( 1 )
Recent research papers ( 44 )
	Arnold et al., 2013, Science 339(6123): 1074--1077 Genome-wide quantitative enhancer activity maps identified by STARR-seq. [FBrf0220944] Caviglia and Luschnig, 2013, Development 140(6): 1240--1249 The ETS domain transcriptional repressor Anterior open inhibits MAP kinase and Wingless signaling to couple tracheal cell fate with branch identity. [FBrf0220890] Pitsouli and Perrimon, 2013, Sci. Signal. 6(263): ra12 The homeobox transcription factor cut coordinates patterning and growth during Drosophila airway remodeling. [FBrf0220848] Schaub and Frasch, 2013, Dev. Biol. 376(2): 245--259 Org-1 is required for the diversification of circular visceral muscle founder cells and normal midgut morphogenesis. [FBrf0221030] Aboukhalil and Bulyk, 2012, Bioinformatics 28(11): 1446--1454 LOESS correction for length variation in gene set-based genomic sequence analysis. [FBrf0218376] Avet-Rochex et al., 2012, Development 139(15): 2763--2772 Concerted control of gliogenesis by InR/TOR and FGF signalling in the Drosophila post-embryonic brain. [FBrf0218842] Butchar et al., 2012, Genetics 191(4): 1213--1226 New negative feedback regulators of egfr signaling in Drosophila. [FBrf0219175] Fabian et al., 2012, Mol. Ecol. 21(19): 4748--4769 Genome-wide patterns of latitudinal differentiation among populations of Drosophila melanogaster from North America. [FBrf0219505] Fuchs et al., 2012, Proc. Natl. Acad. Sci. U.S.A. 109(5): 1572--1577 Transcriptional interpretation of the EGF receptor signaling gradient. [FBrf0217355] Herz et al., 2012, Mol. Cell. Biol. 32(9): 1683--1693 Polycomb repressive complex 2-dependent and -independent functions of jarid2 in transcriptional regulation in Drosophila. [FBrf0218000] Jones et al., 2012, Cell. Microbiol. 14(2): 274--285 Aeromonas salmonicida-secreted protein AopP is a potent inducer of apoptosis in a mammalian and a Drosophila model. [FBrf0217270] Junion et al., 2012, Cell 148(3): 473--486 A transcription factor collective defines cardiac cell fate and reflects lineage history. [FBrf0217404] Lau et al., 2012, Protein Sci. 21(11): 1716--1725 The PNT domain from Drosophila pointed-P2 contains a dynamic N-terminal helix preceded by a disordered phosphoacceptor sequence. [FBrf0219713] Mackay et al., 2012, Nature 482(7384): 173--178 The Drosophila melanogaster Genetic Reference Panel. [FBrf0217434] Manning et al., 2012, Cell Rep. 2(4): 1002--1013 A Resource for Manipulating Gene Expression and Analyzing cis-Regulatory Modules in the Drosophila CNS. [FBrf0219785] Mou et al., 2012, Proc. Natl. Acad. Sci. U.S.A. 109(8): 2949--2954 Control of target gene specificity during metamorphosis by the steroid response gene E93. 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